GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1153	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1628	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	2407	3372	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	138	3081	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	1882	3081	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	5280723	3081	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	CHEMBL495	3081	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	DB00770	3081	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	4150	788	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2389	3331	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2105	3054	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	37	None	-85	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	3042	1414	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	17676	7072	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7072	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7072	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	11001318	78150	69	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	2	1	3	4.5	O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1	10.1038/s41467-023-40064-9
	CHEMBL2103837	78150	69	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	2	1	3	4.5	O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1	10.1038/s41467-023-40064-9
	135398737	958	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	36811	1454	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	535	1454	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	937	1454	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL926	1454	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00841	1454	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	25102847	78221	93	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78221	93	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	228	445	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	28	None	-14	20	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	168871	89130	14	None	1	13	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	1	13	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	6077	150698	31	None	-44	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150698	31	None	-44	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	54682461	84686	62	None	-3	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84686	62	None	-3	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	55645	84370	8	None	-53	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84370	8	None	-53	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	31101	729	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	26879	37294	63	None	13	2	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	204	1	0	3	2.1	c1ccc([C@H]2CN3CCSC3=N2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1454	37294	63	None	13	2	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	204	1	0	3	2.1	c1ccc([C@H]2CN3CCSC3=N2)cc1	10.1038/s41467-023-40064-9
	24826799	10798	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10798	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2335	11848	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11848	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11848	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11848	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	4066	204626	78	None	-1071	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204626	78	None	-1071	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	154257	178619	67	None	-77	19	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-77	19	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	54454	5258	88	None	-2	14	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5258	88	None	-2	14	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	60606	61560	73	None	-9	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61560	73	None	-9	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	102	4127	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	5284537	33613	31	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	374	1	1	3	4.0	CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL142130	33613	31	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	374	1	1	3	4.0	CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	1201549	597	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2136	3095	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	10184665	3991	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3991	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3991	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3991	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3991	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	1209	1658	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	55483	205097	40	None	-144	11	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	CHEMBL77622	205097	40	None	-144	11	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	46780481	107531	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107531	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107531	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107531	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	71137	78243	18	None	-	1	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	12	2	9	2.7	CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC	10.1038/s41467-023-40064-9
	CHEMBL2106351	78243	18	None	-	1	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	12	2	9	2.7	CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC	10.1038/s41467-023-40064-9
	104850	3330	96	None	-2290	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	96	None	-2290	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	96	None	-2290	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	96	None	-2290	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	96	None	-2290	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	135564886	14493	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	135673376	14493	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	137157436	14493	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	145948239	14493	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71587099	14493	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1201304	14493	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71496458	115564	87	None	-72	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115564	87	None	-72	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	150	2509	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1960	2857	67	None	-24	18	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2857	67	None	-24	18	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2857	67	None	-24	18	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2857	67	None	-24	18	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2857	67	None	-24	18	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	213046	2385	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2146	3100	67	None	-851	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3100	67	None	-851	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3100	67	None	-851	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3100	67	None	-851	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3100	67	None	-851	14	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL508338	188966	0	None	-89	15	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	1028	291	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	135398745	2914	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135409453	3773	41	None	-208	35	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	41	None	-208	35	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	41	None	-208	35	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	10531	1420	21	None	-1949	25	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	21	None	-1949	25	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	21	None	-1949	25	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	21	None	-1949	25	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	21	None	-1949	25	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	37	778	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1816	2540	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	2865	4143	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	68555	103112	21	None	3	7	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	103112	21	None	3	7	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	214	3860	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	25382	9157	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9157	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	49806720	60080	99	None	-9	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1738797	60080	99	None	-9	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	5472	205818	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	205818	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	205818	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2601	3780	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	242	470	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-794	33	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	103	4153	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3718	52037	73	None	-	1	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	281	3	1	2	3.0	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL15870	52037	73	None	-	1	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	281	3	1	2	3.0	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	1043	1582	14	None	-5011	22	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1582	14	None	-5011	22	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1582	14	None	-5011	22	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1582	14	None	-5011	22	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1582	14	None	-5011	22	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	1353	1911	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2220	3134	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2337	3256	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5852	2617	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9931891	2617	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL239226	2617	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	16363	596	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	1830	2590	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	681	1465	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	940	1465	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	947	1465	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL59	1465	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00988	1465	72	None	-77	15	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	212	3806	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	10020353	13889	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL1196161	13889	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL556024	13889	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	133538	3619	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	8443	3619	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL574558	3619	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	146025713	171611	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	171611	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025713	171611	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	171611	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	166425	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166425	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	166425	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166425	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75202022	170810	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1016/j.ejmech.2022.114378
	CHEMBL4453318	170810	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1016/j.ejmech.2022.114378
	16219951	172060	2	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL4472022	172060	2	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	75202022	170810	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4453318	170810	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	173871	3614	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	936	3614	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1193571	3614	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	46869265	16257	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	CHEMBL1224527	16257	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	10742	3617	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	1225	3617	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL35354	3617	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	92044504	171727	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	171727	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	92044504	171727	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	171727	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	1241	100179	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL288090	100179	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL552611	100179	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	44320092	161887	0	None	346	2	Human	9.0	pEC50	=	9.0	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL415080	161887	0	None	346	2	Human	9.0	pEC50	=	9.0	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	167715	2876	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	2876	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	2876	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	167715	2876	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	2876	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	2876	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	1242	3613	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	935	3613	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL286080	3613	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	10506	2524	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	86290953	2524	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	CHEMBL3421729	2524	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	135	169282	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	3702506	169282	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	CHEMBL441343	169282	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	75201961	169630	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4437012	169630	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	75201961	169630	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4437012	169630	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	146025701	170571	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	170571	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	146025701	170571	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	170571	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	44320024	107067	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315750	107067	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442480	175270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	44320050	106831	0	None	1	3	Rat	8.8	pEC50	=	8.8	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	106831	0	None	1	3	Rat	8.8	pEC50	=	8.8	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442480	175270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	146025715	176196	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4593703	176196	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025715	176196	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4593703	176196	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	122324	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	6077	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	CHEMBL86931	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	122324	205	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	6077	205	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	CHEMBL86931	205	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	122324	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	90134269	174206	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4548284	174206	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	75201899	171916	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	CHEMBL4469983	171916	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	71722299	102480	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397383	102480	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040217	102480	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	44282985	120480	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL35426	120480	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	146025707	171107	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4457872	171107	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44320256	206313	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87172	206313	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	13720688	11554	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1180542	11554	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL129634	11554	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	146025696	169703	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4437975	169703	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	44331742	4440	0	None	-	1	Rat	6.0	pEC50	=	6	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	269	3	3	3	2.7	Oc1ccc2c(c1O)CCC(NCc1ccccc1)C2	10.1021/jm9502100
	CHEMBL101617	4440	0	None	-	1	Rat	6.0	pEC50	=	6	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	269	3	3	3	2.7	Oc1ccc2c(c1O)CCC(NCc1ccccc1)C2	10.1021/jm9502100
	14708665	168205	1	None	-	1	Rat	5.0	pEC50	=	5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	CHEMBL43345	168205	1	None	-	1	Rat	5.0	pEC50	=	5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	146025696	169703	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4437975	169703	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	146025707	171107	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4457872	171107	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	166425	19	None	95	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166425	19	None	95	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	146034919	192200	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2cccc(OC(F)F)c2)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5204559	192200	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2cccc(OC(F)F)c2)cc1	10.1021/acs.jmedchem.2c00949
	146025721	171709	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4466769	171709	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	10684715	160640	0	None	-	1	Goldfish	8.0	pEC50	=	8.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL41132	160640	0	None	-	1	Goldfish	8.0	pEC50	=	8.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	71563083	87572	0	None	19	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335737	87572	0	None	19	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	75201901	166425	19	None	95	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	CHEMBL4277264	166425	19	None	95	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	146025721	171709	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4466769	171709	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	44276535	98389	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL275379	98389	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	44417647	82161	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL1203924	82161	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL216945	82161	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	24878061	141411	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	CHEMBL384046	141411	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	146025709	174581	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4556763	174581	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	145982261	166732	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4283176	166732	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	146192959	170515	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1cc(F)ccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4449550	170515	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1cc(F)ccc1Cl	10.1021/acsmedchemlett.9b00547
	44282985	120480	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL35426	120480	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	130442557	167073	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4289538	167073	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	146025709	174581	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4556763	174581	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71722297	102472	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397382	102472	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040156	102472	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	85090332	180719	0	None	-9	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4755709	180719	0	None	-9	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	90134199	172242	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4474245	172242	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	90134199	172242	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4474245	172242	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	44320303	163967	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420788	163967	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442471	176084	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	176084	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	681	1465	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	940	1465	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	947	1465	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	CHEMBL59	1465	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	DB00988	1465	72	None	-77	15	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	44554468	106268	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099225	106268	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139011	106268	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	146025716	173965	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4541632	173965	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44276651	99740	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL284959	99740	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	85090319	180610	0	None	-5	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4754602	180610	0	None	-5	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	130442534	166897	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286177	166897	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	2030130	20979	16	None	-6	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL1311333	20979	16	None	-6	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	146025716	173965	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4541632	173965	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	145988779	167279	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293356	167279	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	44320328	206228	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	CHEMBL86669	206228	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	10689581	100163	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL287931	100163	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	3106	48520	16	None	-25	3	Rat	4.9	pEC50	=	4.9	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1021/jm00390a009
	CHEMBL15564	48520	16	None	-25	3	Rat	4.9	pEC50	=	4.9	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1021/jm00390a009
	168278276	191116	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	295	5	1	3	2.6	CNS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187937	191116	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	295	5	1	3	2.6	CNS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	146192950	176031	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	397	4	2	3	3.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1F	10.1021/acsmedchemlett.9b00547
	CHEMBL4590150	176031	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	397	4	2	3	3.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1F	10.1021/acsmedchemlett.9b00547
	168280742	191084	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	230	4	0	2	3.5	O=Cc1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187578	191084	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	230	4	0	2	3.5	O=Cc1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	130442471	176084	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	176084	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	146192960	171519	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4464150	171519	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44320116	164108	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	164108	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	117720272	118814	3	None	18	3	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	CHEMBL3421730	118814	3	None	18	3	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	1242	3613	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	935	3613	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	CHEMBL286080	3613	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	146025697	175351	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4574454	175351	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	168276676	190462	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	280	4	0	3	3.1	CS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5178743	190462	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	280	4	0	3	3.1	CS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	146025697	175351	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4574454	175351	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	130442561	166893	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286110	166893	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	161665	172585	35	None	-28	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	172585	35	None	-28	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	85090324	180692	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4755481	180692	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	6603820	95774	19	None	1	7	Human	7.9	pEC50	=	7.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL25856	95774	19	None	1	7	Human	7.9	pEC50	=	7.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	146025712	175483	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4577432	175483	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	10666053	100386	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289927	100386	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	146025703	171267	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4460394	171267	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	75201901	166425	19	None	95	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166425	19	None	95	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	146025703	171267	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4460394	171267	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	15696481	79666	0	None	75	2	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2115213	79666	0	None	75	2	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	146025712	175483	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4577432	175483	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	132435	130709	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL130795	130709	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL368456	130709	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	146025704	172348	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4475848	172348	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44554818	104266	0	None	-89	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099234	104266	0	None	-89	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44554472	106283	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099226	106283	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139040	106283	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	85090328	181035	0	None	-6	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4759339	181035	0	None	-6	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090323	181922	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4779641	181922	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	146025813	175587	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175587	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025813	175587	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175587	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90134304	166514	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b00435
	CHEMBL4278861	166514	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b00435
	146025821	169671	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	169671	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025821	169671	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	169671	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025820	173222	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	173222	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025820	173222	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	173222	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	85090329	182682	0	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4789255	182682	0	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	137364078	192225	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	4	0	3	3.7	CN=S(C)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5204914	192225	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	4	0	3	3.7	CN=S(C)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	3246443	37686	2	None	-16	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	37686	2	None	-16	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	146025704	172348	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4475848	172348	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44320053	205773	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	205773	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	11938	2412	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	146192952	2412	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4468760	2412	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44287454	13228	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1191276	13228	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL542351	13228	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	146025718	175193	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4570859	175193	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	117720272	118814	3	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	118814	3	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	146025718	175193	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4570859	175193	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	85090333	181301	0	None	-10	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4762375	181301	0	None	-10	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	76284419	183248	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796389	183248	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	85090325	179749	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4744261	179749	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	75201901	166425	19	None	95	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b00435
	CHEMBL4277264	166425	19	None	95	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b00435
	10854877	142015	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL38757	142015	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10733562	147014	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL39266	147014	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	1242	3613	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	935	3613	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	CHEMBL286080	3613	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	136326241	179428	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4740312	179428	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	146192966	175316	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acsmedchemlett.9b00547
	CHEMBL4573538	175316	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acsmedchemlett.9b00547
	44319988	206079	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85552	206079	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10758745	100433	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	100433	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	100433	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44276414	97628	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL27101	97628	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	155548298	173751	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	473	6	2	5	3.9	C[C@H]1c2cccc(-c3cnn(CCO)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4536851	173751	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	473	6	2	5	3.9	C[C@H]1c2cccc(-c3cnn(CCO)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44320001	206016	0	None	-3	2	Rat	7.7	pEC50	=	7.7	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	206016	0	None	-3	2	Rat	7.7	pEC50	=	7.7	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	1242	3613	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	935	3613	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	CHEMBL286080	3613	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	146025729	174159	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4546823	174159	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44276652	99494	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL283247	99494	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	146025729	174159	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4546823	174159	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	85090322	179459	0	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740678	179459	0	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090321	182813	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4790909	182813	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	168294420	192510	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccccc2OC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5209228	192510	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccccc2OC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	6603820	95774	19	None	1	7	Human	7.7	pEC50	=	7.7	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	CHEMBL25856	95774	19	None	1	7	Human	7.7	pEC50	=	7.7	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	44554820	106286	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099222	106286	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139044	106286	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	146025724	172264	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4474567	172264	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025819	175652	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4581262	175652	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025819	175652	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4581262	175652	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025724	172264	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4474567	172264	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	85090334	180625	0	None	-11	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4754761	180625	0	None	-11	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090331	181453	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4764398	181453	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	12668019	10239	8	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL1160787	10239	8	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	44320061	106032	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313304	106032	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	14809027	107029	0	None	3	3	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	107029	0	None	3	3	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	122324	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	205	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	146025727	171685	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171685	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025727	171685	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171685	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	171908	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171908	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	171908	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171908	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	10506	2524	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	2524	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	2524	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	130442473	167337	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	167337	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	167337	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	167337	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	1153	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	12668023	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026874	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026875	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	3341	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	6603851	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	933	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	939	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	985	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1160786	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1161520	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL588	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	DB00800	1628	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	681	1465	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	940	1465	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	947	1465	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	CHEMBL59	1465	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	DB00988	1465	72	None	-77	15	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	75201899	171916	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1016/j.ejmech.2022.114378
	CHEMBL4469983	171916	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1016/j.ejmech.2022.114378
	201536	111468	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL3276140	111468	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	201536	111468	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL3276140	111468	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	133741	199066	11	None	-38	2	Rat	4.7	pEC50	=	4.7	Functional	Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	276	7	2	3	2.6	CCCN(CCC)CCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	CHEMBL587	199066	11	None	-38	2	Rat	4.7	pEC50	=	4.7	Functional	Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	276	7	2	3	2.6	CCCN(CCC)CCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	90134211	174029	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4543306	174029	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	71722293	102475	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL2397380	102475	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL3040164	102475	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	44554984	104263	0	None	-208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099231	104263	0	None	-208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155541775	173044	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	CHEMBL4519136	173044	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	137364059	190320	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	3.4	C[S+]([O-])c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5176312	190320	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	3.4	C[S+]([O-])c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	168289194	191494	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	4.5	O=Cc1ccc(-c2ccccc2SC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5193714	191494	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	4.5	O=Cc1ccc(-c2ccccc2SC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	10662054	84412	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114444	84412	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219803	84412	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	90134211	174029	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4543306	174029	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	155519631	170405	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	CHEMBL4448100	170405	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	145979741	166685	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4282096	166685	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	6917970	3691	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	8370	3691	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	CHEMBL487387	3691	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	44276412	97665	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL27117	97665	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44320116	164108	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	164108	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44554649	104267	0	None	-457	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099235	104267	0	None	-457	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44276557	99316	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL282136	99316	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	21936384	191512	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccc(OC(F)F)cc2)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5193924	191512	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccc(OC(F)F)cc2)cc1	10.1021/acs.jmedchem.2c00949
	681	1465	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	940	1465	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	947	1465	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	CHEMBL59	1465	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	DB00988	1465	72	None	-77	15	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	15696482	79559	0	None	21	2	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2114209	79559	0	None	21	2	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	85090326	182773	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4790277	182773	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	44320218	206424	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	CHEMBL87897	206424	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	146025811	171761	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171761	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025811	171761	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171761	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10640108	84411	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114441	84411	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219802	84411	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	9841398	99519	4	None	-2	3	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL28338	99519	4	None	-2	3	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	44320267	206212	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	206212	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10588327	13781	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1195441	13781	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL554571	13781	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	145990190	166853	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4285528	166853	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	85090337	183281	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796761	183281	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	21786101	155732	0	None	-38	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	261	2	2	3	2.7	CCCN1CCC[C@@H]2Cc3c(ccc(O)c3O)C[C@H]21	10.1016/j.bmc.2007.06.036
	CHEMBL405519	155732	0	None	-38	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	261	2	2	3	2.7	CCCN1CCC[C@@H]2Cc3c(ccc(O)c3O)C[C@H]21	10.1016/j.bmc.2007.06.036
	1241	100179	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	CHEMBL288090	100179	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	CHEMBL552611	100179	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	228	445	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	33	445	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	6005	445	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	CHEMBL53	445	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	DB00714	445	28	None	-14	20	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	155541775	173044	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	CHEMBL4519136	173044	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	145979741	166685	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b00435
	CHEMBL4282096	166685	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b00435
	145979741	166685	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1016/j.ejmech.2022.114378
	CHEMBL4282096	166685	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1016/j.ejmech.2022.114378
	4901726	180799	9	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4756486	180799	9	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	146025714	170298	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4446525	170298	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025714	170298	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4446525	170298	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	167337	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4294397	167337	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	146025730	171968	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4470740	171968	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025730	171968	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4470740	171968	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	9796958	146578	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	146578	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	146578	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	146578	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44320304	107035	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	367	5	3	4	4.5	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNCc1ccccc1	10.1021/jm00112a034
	CHEMBL315516	107035	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	367	5	3	4	4.5	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNCc1ccccc1	10.1021/jm00112a034
	85090318	179445	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740497	179445	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	10758744	100507	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL291100	100507	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	10710466	156415	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL40667	156415	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	2407	3372	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	59227	3372	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	941	3372	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	CHEMBL1303	3372	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	DB05271	3372	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	146192958	170514	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4449549	170514	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl	10.1021/acsmedchemlett.9b00547
	146192964	174710	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4559891	174710	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	10519435	171469	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL446350	171469	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	15981509	141958	1	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	CHEMBL387250	141958	1	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	10856744	60025	11	None	6	2	Rat	6.5	pEC50	=	6.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.	ChEMBL	210	2	3	5	1.2	NCCc1ccc(O)c2nc(O)sc12	10.1021/jm00390a009
	CHEMBL17357	60025	11	None	6	2	Rat	6.5	pEC50	=	6.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.	ChEMBL	210	2	3	5	1.2	NCCc1ccc(O)c2nc(O)sc12	10.1021/jm00390a009
	85090330	181073	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4759814	181073	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	10506	2524	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	2524	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	2524	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	44320050	106831	0	None	-1	3	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	106831	0	None	-1	3	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44320357	206399	0	None	54	2	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87734	206399	0	None	54	2	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86293768	118815	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421836	118815	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	228	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6604773	16258	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CC2	10.1016/j.bmc.2010.07.052
	CHEMBL1224528	16258	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CC2	10.1016/j.bmc.2010.07.052
	228	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	445	28	None	-14	20	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6852376	91599	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL1467585	91599	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL24077	91599	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL503958	91599	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	6603820	95774	19	None	-1	7	Rat	7.5	pEC50	=	7.5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	CHEMBL25856	95774	19	None	-1	7	Rat	7.5	pEC50	=	7.5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	145867041	174529	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4555682	174529	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	44320327	163424	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	163424	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	1242	3613	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	3613	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	3613	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	137364067	191075	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	5	1	3	4.1	CCS(=N)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187471	191075	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	5	1	3	4.1	CCS(=N)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	10709445	101363	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115377	101363	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL296993	101363	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	3033200	174527	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	174527	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	3033200	174527	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	174527	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	117720272	118814	3	None	-34	3	Mouse	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	118814	3	None	-34	3	Mouse	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	71722291	102460	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397385	102460	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040059	102460	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	146025708	173524	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4531083	173524	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	25142456	82406	2	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	CHEMBL217299	82406	2	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	146025708	173524	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4531083	173524	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44276404	99078	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL28054	99078	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	10802235	13259	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1191487	13259	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL542593	13259	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	10732044	84413	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114440	84413	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219804	84413	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	75201901	166425	19	None	95	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166425	19	None	95	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	44554474	106285	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099227	106285	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139043	106285	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155519631	170405	0	None	-15	2	Rat	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlPositive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	CHEMBL4448100	170405	0	None	-15	2	Rat	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlPositive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	146025818	169762	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4438800	169762	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	44320076	206426	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87910	206426	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	681	1465	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	940	1465	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	947	1465	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	CHEMBL59	1465	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	DB00988	1465	72	None	-77	15	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	146025706	171624	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465592	171624	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	681	1465	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	940	1465	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	947	1465	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	CHEMBL59	1465	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	DB00988	1465	72	None	-1380	15	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	146025818	169762	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4438800	169762	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025706	171624	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465592	171624	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	44555137	104264	0	None	-28	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099232	104264	0	None	-28	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155537335	172312	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	388	2	1	6	3.2	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1nccc2occc12	10.1021/acsmedchemlett.9b00050
	CHEMBL4475239	172312	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	388	2	1	6	3.2	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1nccc2occc12	10.1021/acsmedchemlett.9b00050
	681	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	940	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	947	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	CHEMBL59	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	DB00988	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	44320002	107041	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315535	107041	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44276556	99702	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL284644	99702	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	146025814	172779	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172779	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6852376	91599	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL1467585	91599	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL24077	91599	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL503958	91599	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	1242	3613	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	935	3613	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	CHEMBL286080	3613	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	146025814	172779	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172779	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10540201	100229	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL288536	100229	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	681	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	940	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	947	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	CHEMBL59	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	DB00988	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	44320267	206212	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	206212	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44555138	104265	0	None	-117	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099233	104265	0	None	-117	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	49866139	16252	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CO2	10.1016/j.bmc.2010.07.052
	CHEMBL1224452	16252	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CO2	10.1016/j.bmc.2010.07.052
	1218	3616	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	938	3616	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	CHEMBL353335	3616	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	44554987	104268	0	None	-114	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099239	104268	0	None	-114	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	13720694	12972	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1189465	12972	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL538785	12972	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	13720690	13090	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1190300	13090	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL540575	13090	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	155521159	170531	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	374	2	1	6	2.9	Cc1c(-c2ccc3c(c2)CCN3c2nccc3occc23)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	CHEMBL4449782	170531	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	374	2	1	6	2.9	Cc1c(-c2ccc3c(c2)CCN3c2nccc3occc23)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	6917970	3691	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	8370	3691	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	CHEMBL487387	3691	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	90134304	166514	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	CHEMBL4278861	166514	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	85090339	182305	0	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	CHEMBL4784143	182305	0	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	10518837	100473	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290842	100473	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	76284418	182318	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4784295	182318	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090320	182563	0	None	-10	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4787728	182563	0	None	-10	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	53494980	66494	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822918	66494	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852340	66494	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	10830234	100377	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289867	100377	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	681	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	940	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	947	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	CHEMBL59	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	DB00988	1465	72	None	-77	15	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	86302251	172855	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	448	4	1	5	3.5	CN(Cc1nc2cc(Br)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	CHEMBL4514994	172855	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	448	4	1	5	3.5	CN(Cc1nc2cc(Br)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	155549423	173813	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	349	3	2	7	2.3	Cc1c(-c2ccc(Nc3nccc4occc34)nc2)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	CHEMBL4538358	173813	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	349	3	2	7	2.3	Cc1c(-c2ccc(Nc3nccc4occc34)nc2)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	44320327	163424	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	163424	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	85470885	174660	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	438	4	1	5	3.8	CN(Cc1nc2cc(C(F)(F)F)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	CHEMBL4558647	174660	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	438	4	1	5	3.8	CN(Cc1nc2cc(C(F)(F)F)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	10081286	98774	2	None	1	2	Rat	5.3	pEC50	=	5.3	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effectDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect	ChEMBL	192	2	3	3	0.4	NCCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	CHEMBL278188	98774	2	None	1	2	Rat	5.3	pEC50	=	5.3	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effectDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect	ChEMBL	192	2	3	3	0.4	NCCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	10588326	158866	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL40950	158866	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	10831251	163173	0	None	-	1	Goldfish	6.3	pEC50	=	6.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL41809	163173	0	None	-	1	Goldfish	6.3	pEC50	=	6.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	13864380	206432	1	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87958	206432	1	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	13864381	208344	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL542683	208344	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL99361	208344	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	44331310	107366	1	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9502100
	CHEMBL317741	107366	1	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9502100
	168291403	192006	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	281	4	1	3	2.3	NS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5201584	192006	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	281	4	1	3	2.3	NS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	71563084	87571	0	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335736	87571	0	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	64638	106141	2	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	106141	2	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	6603703	208	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	9637	208	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	CHEMBL291143	208	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	44320001	206016	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	206016	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86764103	132437	13	None	2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL3697578	132437	13	None	2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	6453963	71539	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	CHEMBL1950491	71539	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	CHEMBL1962947	71539	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	130442590	169799	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	169799	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	130442590	169799	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	169799	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	44320026	206099	0	None	131	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85689	206099	0	None	131	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	117720272	118814	3	None	18	3	Human	8.2	pEC50	=	8.2	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	118814	3	None	18	3	Human	8.2	pEC50	=	8.2	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	10851849	169933	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL44414	169933	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	13720686	11560	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1180562	11560	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL131313	11560	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	681	1465	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	940	1465	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	947	1465	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	CHEMBL59	1465	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	DB00988	1465	72	None	-1380	15	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	146025816	169978	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169978	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025816	169978	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	169978	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	9796958	146578	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	146578	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	146578	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	146578	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	228	445	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	33	445	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	6005	445	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	CHEMBL53	445	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	DB00714	445	28	None	-14	20	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	44320053	205773	0	None	-3	2	Rat	7.3	pEC50	=	7.3	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	205773	0	None	-3	2	Rat	7.3	pEC50	=	7.3	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	146025720	172948	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4517022	172948	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025720	172948	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4517022	172948	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025700	175372	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4574838	175372	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	146192953	171610	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1ccc(F)cc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4465386	171610	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1ccc(F)cc1Cl	10.1021/acsmedchemlett.9b00547
	145992269	166953	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4287192	166953	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	146025700	175372	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4574838	175372	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	85090335	181114	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	CHEMBL4760355	181114	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	6852376	91599	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1467585	91599	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL24077	91599	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL503958	91599	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	145867041	174529	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4555682	174529	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	1153	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	12668023	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	30026874	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	30026875	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	3341	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	6603851	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	933	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	939	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	985	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL1160786	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL1161520	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL588	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	DB00800	1628	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	53494976	66600	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822919	66600	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852625	66600	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	155560177	174930	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	378	3	1	6	2.7	Cc1nc2c(c(Oc3ccc(-c4c(C)c(=O)[nH]c(=O)n4C)c(C)c3)n1)CCC2	10.1021/acsmedchemlett.9b00050
	CHEMBL4565185	174930	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	378	3	1	6	2.7	Cc1nc2c(c(Oc3ccc(-c4c(C)c(=O)[nH]c(=O)n4C)c(C)c3)n1)CCC2	10.1021/acsmedchemlett.9b00050
	53494978	66502	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822920	66502	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852349	66502	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	44320129	167894	0	None	56	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL431220	167894	0	None	56	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44319976	106963	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	CHEMBL315005	106963	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	44320378	206063	0	None	63	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85409	206063	0	None	63	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10015860	99277	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL281932	99277	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	12170	3910	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	137364063	3910	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	CHEMBL5172089	3910	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	146025699	170487	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4449153	170487	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025710	170116	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4443737	170116	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025699	170487	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4449153	170487	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	155534541	171973	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	380	4	2	6	2.5	CC(=O)Nc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	10.1021/acsmedchemlett.9b00050
	CHEMBL4470808	171973	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	380	4	2	6	2.5	CC(=O)Nc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	10.1021/acsmedchemlett.9b00050
	146025710	170116	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4443737	170116	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	10506	2524	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	2524	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	2524	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	44276405	100109	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	CHEMBL287513	100109	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	130442514	166532	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4279267	166532	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	10666423	162302	0	None	-	1	Goldfish	6.2	pEC50	=	6.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	363	1	3	4	4.7	Cc1cccc(-c2cc3c(s2)CN[C@H]2CCc4cc(O)c(O)cc4[C@H]32)c1	10.1021/jm970038v
	CHEMBL416435	162302	0	None	-	1	Goldfish	6.2	pEC50	=	6.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	363	1	3	4	4.7	Cc1cccc(-c2cc3c(s2)CN[C@H]2CCc4cc(O)c(O)cc4[C@H]32)c1	10.1021/jm970038v
	146025719	171207	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4459395	171207	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025719	171207	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4459395	171207	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44319915	205965	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84557	205965	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	146025726	170767	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4452764	170767	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025823	169577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	169577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	1242	3613	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	935	3613	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	CHEMBL286080	3613	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	146025823	169577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	169577	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	146025726	170767	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4452764	170767	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44320123	107083	0	None	4	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL315849	107083	0	None	4	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	15696487	163799	1	None	97	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420604	163799	1	None	97	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10758745	100433	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	100433	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	100433	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	14809027	107029	0	None	-3	3	Rat	8.2	pEC50	=	8.2	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	107029	0	None	-3	3	Rat	8.2	pEC50	=	8.2	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	6603820	95774	19	None	1	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2011.07.057
	CHEMBL25856	95774	19	None	1	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2011.07.057
	146025728	176013	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4589664	176013	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025728	176013	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4589664	176013	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	6604005	157117	2	None	1	4	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm9502100
	CHEMBL407489	157117	2	None	1	4	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm9502100
	133642	171951	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	171951	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	133642	171951	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	171951	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	44554986	106284	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099236	106284	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139041	106284	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	71722301	102473	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3040157	102473	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3216146	102473	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	130442508	171083	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	CHEMBL4457399	171083	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	71563082	87281	0	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2331599	87281	0	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	86293768	118815	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	CHEMBL3421836	118815	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	10664137	162755	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL417164	162755	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	130442508	171083	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	CHEMBL4457399	171083	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	146025725	171549	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4464545	171549	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025725	171549	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4464545	171549	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	71722295	102467	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397381	102467	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040115	102467	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	10546132	161255	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL41196	161255	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	146025711	173032	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4518891	173032	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025711	173032	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4518891	173032	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71562964	87575	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335740	87575	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	6603703	208	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	9637	208	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	CHEMBL291143	208	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	64638	106141	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	106141	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44276551	97376	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL26965	97376	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44276552	99880	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL285924	99880	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10497993	168474	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL43514	168474	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	44276572	96648	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL26365	96648	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	75201961	169630	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4437012	169630	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	146192955	171526	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	409	4	1	4	3.8	C[C@H]1c2cccc(-c3cnn(C)c3)c2C[C@H](CO)N1C(=O)Cc1ccccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4464215	171526	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	409	4	1	4	3.8	C[C@H]1c2cccc(-c3cnn(C)c3)c2C[C@H](CO)N1C(=O)Cc1ccccc1Cl	10.1021/acsmedchemlett.9b00547
	10519436	11226	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1178784	11226	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL41238	11226	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	118445551	167315	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	CHEMBL4294009	167315	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	13851595	174505	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3098131	174505	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL455497	174505	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	85090338	180761	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4756163	180761	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	14809026	205787	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL83080	205787	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	14809026	205787	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL83080	205787	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10684714	100310	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115372	100310	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL289283	100310	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	146025817	176017	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	176017	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025817	176017	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	176017	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6603820	95774	19	None	-6	7	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL25856	95774	19	None	-6	7	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	10592479	100265	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL288846	100265	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	146025705	170614	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4450916	170614	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44554982	104262	0	None	-58	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099230	104262	0	None	-58	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44320257	206175	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86325	206175	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	146025705	170614	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4450916	170614	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	90142280	167296	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293757	167296	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	9841398	99519	4	None	2	3	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL28338	99519	4	None	2	3	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10546131	100409	0	None	-	1	Goldfish	7.0	pEC50	=	7.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290149	100409	0	None	-	1	Goldfish	7.0	pEC50	=	7.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	6852376	91599	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL1467585	91599	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL24077	91599	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL503958	91599	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	155558060	174684	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	414	4	1	6	3.0	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1ncccc1OC(F)F	10.1021/acsmedchemlett.9b00050
	CHEMBL4559240	174684	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	414	4	1	6	3.0	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1ncccc1OC(F)F	10.1021/acsmedchemlett.9b00050
	146025822	173791	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4537900	173791	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025822	173791	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4537900	173791	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	107930	1529	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	3304	1529	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	CHEMBL298406	1529	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	DB12273	1529	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	3036864	202754	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1256645	202754	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1814790	202754	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL62	202754	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	155561845	175718	0	None	-5	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4582377	175718	0	None	-5	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	15061351	86479	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	367	2	0	6	3.0	COc1ccc2c(c1OC(C)=O)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL2314734	86479	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	367	2	0	6	3.0	COc1ccc2c(c1OC(C)=O)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	71453989	83528	0	None	-1	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	298	0	0	4	4.0	Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2	10.1021/jm1012374
	CHEMBL2203622	83528	0	None	-1	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	298	0	0	4	4.0	Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2	10.1021/jm1012374
	70682088	76068	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057446	76068	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	46931072	202045	1	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL608530	202045	1	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	3246545	202474	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	202474	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	202474	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	70690500	76073	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057455	76073	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	155538443	172382	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4476383	172382	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	146025811	171761	0	None	-416	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	171761	0	None	-416	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	1353	1911	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3559	1911	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	86	1911	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	CHEMBL54	1911	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	DB00502	1911	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	72301	186118	76	None	-3	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL487182	186118	76	None	-3	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2019.04.014
	44299467	197556	0	None	-30	2	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	CHEMBL57029	197556	0	None	-30	2	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	3246443	37686	2	None	-16	3	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	37686	2	None	-16	3	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	44537919	198136	0	None	-60	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL574700	198136	0	None	-60	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	72699716	115189	0	None	-12	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344459	115189	0	None	-12	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	161665	172585	35	None	-28	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	172585	35	None	-28	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	70690498	76067	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057445	76067	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	13869636	101705	0	None	-83	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	397	8	0	4	4.7	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1021/jm00393a037
	CHEMBL299471	101705	0	None	-83	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	397	8	0	4	4.7	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1021/jm00393a037
	44299213	100633	0	None	-77	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]1C	10.1021/jm00393a037
	CHEMBL292006	100633	0	None	-77	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]1C	10.1021/jm00393a037
	44299579	197719	0	None	-33	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	CHEMBL57140	197719	0	None	-33	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	18367	194943	30	None	-60	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	341	6	1	3	3.8	O=C(CCCN1CCC(O)(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	CHEMBL54206	194943	30	None	-60	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	341	6	1	3	3.8	O=C(CCCN1CCC(O)(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	3036864	202754	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL1256645	202754	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL1814790	202754	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL62	202754	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	3036864	202754	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL1256645	202754	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL1814790	202754	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL62	202754	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	44299566	196778	0	None	-67	2	Rat	5.5	pIC50	=	5.5	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@H]1C	10.1021/jm00393a037
	CHEMBL56547	196778	0	None	-67	2	Rat	5.5	pIC50	=	5.5	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@H]1C	10.1021/jm00393a037
	44537925	198744	0	None	-162	3	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL582945	198744	0	None	-162	3	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	129103318	167314	0	None	-39	6	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assayAntagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	167314	0	None	-39	6	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assayAntagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	228	445	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	33	445	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	6005	445	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	CHEMBL53	445	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	DB00714	445	28	None	-131	20	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	146025812	174891	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	174891	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025812	174891	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	174891	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90899701	169735	0	None	-5	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	313	1	3	5	2.5	COc1ccc2c(c1O)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	CHEMBL4438471	169735	0	None	-5	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	313	1	3	5	2.5	COc1ccc2c(c1O)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	453215	86481	8	None	7	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)C1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL2314745	86481	8	None	7	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)C1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2019.04.014
	3246545	202474	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	202474	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	202474	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	146025813	175587	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175587	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025813	175587	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	175587	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	3036864	202754	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1256645	202754	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1814790	202754	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL62	202754	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	1353	1911	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3559	1911	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	86	1911	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	CHEMBL54	1911	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	DB00502	1911	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3036864	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	3036864	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	202754	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	72699817	115188	0	None	1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344458	115188	0	None	1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	5018	3549	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	943	3549	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	946	3549	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	CHEMBL13668	3549	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	12269810	86482	8	None	-15	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	327	2	2	5	2.8	COc1ccc2c(c1OC)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	CHEMBL2314747	86482	8	None	-15	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	327	2	2	5	2.8	COc1ccc2c(c1OC)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	24837531	174774	1	None	-4	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	311	2	1	4	3.1	COc1cc2c(cc1OC)C1Cc3ccc(O)cc3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL4561303	174774	1	None	-4	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	311	2	1	4	3.1	COc1cc2c(cc1OC)C1Cc3ccc(O)cc3CN1CC2	10.1016/j.bmc.2019.04.014
	9549058	173150	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.bmc.2019.04.014
	CHEMBL4521450	173150	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.bmc.2019.04.014
	146025814	172779	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172779	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	155552483	174059	0	None	-6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	2	1	6	2.8	COc1cc2c(c(OC)c1O)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4544045	174059	0	None	-6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	2	1	6	2.8	COc1cc2c(c(OC)c1O)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	146025814	172779	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	172779	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	13869644	197252	0	None	-109	2	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	325	6	0	2	4.7	O=C(CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	CHEMBL56843	197252	0	None	-109	2	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	325	6	0	2	4.7	O=C(CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	146025815	169779	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169779	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025815	169779	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	169779	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	156017431	177777	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	CHEMBL4643069	177777	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	11681599	75173	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL203637	75173	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	133538	3619	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	8443	3619	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	CHEMBL574558	3619	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	11558055	73152	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL1204122	73152	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL201170	73152	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11573628	74699	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	CHEMBL203047	74699	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	9992499	73386	0	None	-	0	Human	6.0	pKi	=	6	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	CHEMBL201483	73386	0	None	-	0	Human	6.0	pKi	=	6	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	11716449	141215	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	CHEMBL382850	141215	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	10071501	9879	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	CHEMBL114228	9879	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	1242	3613	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	3613	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	3613	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	11716438	140882	1	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	CHEMBL382010	140882	1	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	16090814	81581	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL216258	81581	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	11566745	74694	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL1202298	74694	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL203029	74694	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	11558247	75422	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	CHEMBL204098	75422	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	11637457	73087	1	None	-	0	Human	6.7	pKi	=	6.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	CHEMBL201093	73087	1	None	-	0	Human	6.7	pKi	=	6.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	9952858	7554	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	CHEMBL108764	7554	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	44408818	140165	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	CHEMBL380330	140165	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	11573806	75416	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	CHEMBL204065	75416	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	10467946	48469	4	None	-	0	Human	8.5	pKi	=	8.5	Functional	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1016/j.ejmech.2022.114378
	CHEMBL155596	48469	4	None	-	0	Human	8.5	pKi	=	8.5	Functional	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1016/j.ejmech.2022.114378
	11623343	140842	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL381936	140842	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11493746	141323	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL383451	141323	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	16090821	81833	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	CHEMBL216439	81833	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	11718008	75291	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL203734	75291	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	137284323	184853	0	None	-	1	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	341	1	1	3	4.9	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1	10.1016/j.bmcl.2021.127911
	CHEMBL4852403	184853	0	None	-	1	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	341	1	1	3	4.9	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1	10.1016/j.bmcl.2021.127911
	11536995	139555	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL379662	139555	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	147230103	180153	0	None	-	2	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2021.127911
	CHEMBL4748915	180153	0	None	-	2	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2021.127911
	5249956	73395	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	CHEMBL201525	73395	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	135398737	958	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	38	958	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	722	958	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	CHEMBL42	958	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	DB00363	958	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	11500677	140848	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL381946	140848	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	147200197	185714	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	317	1	1	3	4.7	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4865663	185714	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	317	1	1	3	4.7	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	11595240	140188	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	CHEMBL380464	140188	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	11558055	73152	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL1204122	73152	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL201170	73152	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	4350931	169313	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL441618	169313	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	4350931	169313	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	CHEMBL441618	169313	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	11522339	75252	1	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	CHEMBL203689	75252	1	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	5249952	73408	7	None	-	0	Human	6.1	pKi	=	6.1	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	CHEMBL201584	73408	7	None	-	0	Human	6.1	pKi	=	6.1	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	135409468	2035	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	333	2035	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	CHEMBL845	2035	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	164623328	185876	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	331	2	1	3	5.0	CCc1ccc2c(c1)C(C1=CCN(C)CC1)=Nc1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4868181	185876	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	331	2	1	3	5.0	CCc1ccc2c(c1)C(C1=CCN(C)CC1)=Nc1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	149505732	186231	0	None	-	1	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	321	1	1	3	4.6	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4873426	186231	0	None	-	1	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	321	1	1	3	4.6	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2021.127911
	1225	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1471	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	133538	3619	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	8443	3619	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	CHEMBL574558	3619	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	12170	3910	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	137364063	3910	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	CHEMBL5172089	3910	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	10506	2524	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	86290953	2524	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	CHEMBL3421729	2524	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	10506	2524	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	86290953	2524	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	CHEMBL3421729	2524	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	122324	205	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	6077	205	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	CHEMBL86931	205	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	11938	2412	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	146192952	2412	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	CHEMBL4468760	2412	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	100	3805	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3805	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3805	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3805	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3805	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		3294	2006	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	2006	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	2006	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	2006	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	2006	111	None	-56	45	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		103	4153	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		46780481	107531	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	107531	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	107531	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	107531	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		17676	7072	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		5281082	7072	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1085	7072	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		2105	3054	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	3054	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	3054	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	3054	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	3054	37	None	-537	33	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL508338	188966	0	None	-	6	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		6237	86804	46	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		CHEMBL232201	86804	46	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		2237	3162	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		3634	3162	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		4887	3162	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		CHEMBL21333	3162	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		DB01411	3162	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		60663	175669	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1421212	175669	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1534525	175669	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL45816	175669	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		1613	2348	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2993	114692	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL121663	114692	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL333826	114692	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		7099	195522	59	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		CHEMBL55400	195522	59	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		4151	3607	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		493	3607	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		5312125	3607	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL24778	3607	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		DB06207	3607	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		2284	3182	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	3182	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	3182	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	3182	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	3182	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		1830	2590	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		207	2590	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		23897	2590	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL460	2590	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		DB01618	2590	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		2520	204008	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	204008	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	204008	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		2865	4143	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		5354	155656	21	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL404849	155656	21	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		82146	4530	113	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		CHEMBL1023	4530	113	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		27901	78207	22	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2105458	78207	22	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		7019	167976	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1308088	167976	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43184	167976	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		133	2496	52	None	-30	42	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		1723	2496	52	None	-30	42	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		28693	2496	52	None	-30	42	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL19215	2496	52	None	-30	42	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		DB13520	2496	52	None	-30	42	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		213046	2385	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	2385	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	2385	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	2385	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	2385	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		1577	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2537	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5355	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5501	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		643497	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		688272	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		958	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		960	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL196677	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL26	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL267044	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB00391	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB16021	3703	110	None	-549	21	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		3652	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		57	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		60809	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		CHEMBL21536	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		DB15357	4097	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		72287	61061	38	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1764	61061	38	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		237	204865	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL546257	204865	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL554190	204865	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL7568	204865	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		1027	1576	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3241	1576	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		7176	1576	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL1106	1576	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB00751	1576	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3055	1433	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		313	1433	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		7163	1433	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL936	1433	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB01231	1433	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		213	3853	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2717	3853	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		5533	3853	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL621	3853	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00656	3853	55	None	-12	44	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2337	3256	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		2406	100404	89	None	-	12	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		CHEMBL290106	100404	89	None	-	12	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		214	3860	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	3860	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	3860	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	3860	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	3860	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	3860	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		9417	133512	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	133512	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	133512	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		47979	78210	59	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL2105581	78210	59	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
		9429	202133	58	None	-	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	202133	58	None	-	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		213046	2385	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	2385	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	2385	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	2385	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	2385	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		60860	205639	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL1615777	205639	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL818	205639	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		2749	344	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5574	344	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7237	344	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL829	344	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01246	344	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		26987	949	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	949	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	949	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	949	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	949	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		3166	169420	23	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL442444	169420	23	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		2398	954	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	954	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	954	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	954	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	954	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		9419	35922	35	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1442422	35922	35	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		6726	1280	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7151	1280	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		749	1280	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL648	1280	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB01176	1280	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		16960	14487	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1201287	14487	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		5584	203211	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL644	203211	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		9853053	120519	74	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		CHEMBL354541	120519	74	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		1765	3817	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		4184	3817	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		9871419	3817	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		CHEMBL398435	3817	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		DB08816	3817	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		54454	5258	88	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
		CHEMBL1064	5258	88	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
		12488	1657	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		941361	1657	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		CHEMBL30008	1657	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		DB04841	1657	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		68802	110035	37	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		CHEMBL32350	110035	37	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		49843517	78294	41	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		CHEMBL2107831	78294	41	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		3606	203488	60	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL6615	203488	60	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		135	2532	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-91	58	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		10219	188796	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL493439	188796	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL50588	188796	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		134	2514	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	2514	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	2514	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	2514	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	2514	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1890	2759	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	2759	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	2759	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	2759	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	2759	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		5489013	57405	32	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		CHEMBL1651913	57405	32	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		115358	101562	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	463	9	2	6	5.9	COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1	10.1038/s41467-023-40064-9
		CHEMBL298470	101562	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	463	9	2	6	5.9	COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1	10.1038/s41467-023-40064-9
		1577	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2537	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5355	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5501	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		643497	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		688272	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		958	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		960	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL196677	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL26	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL267044	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB00391	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB16021	3703	110	None	-549	21	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2162	41514	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1491	41514	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL508338	188966	0	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		5568	197500	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		66069	197500	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL1201102	197500	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL570	197500	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		71277	84539	27	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	789	9	4	15	2.7	CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C	10.1038/s41467-023-40064-9
		CHEMBL2220427	84539	27	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	789	9	4	15	2.7	CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C	10.1038/s41467-023-40064-9
		2286	3183	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		22323	15299	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9571037	15299	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1213553	15299	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		2146	3100	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	3100	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	3100	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	3100	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	3100	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6834	205552	45	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL811	205552	45	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		191	403	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	403	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	403	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	403	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	403	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		1909	2822	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		2559	2822	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		4474	2822	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL1484	2822	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL3302409	2822	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		DB00622	2822	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		212	3806	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2335	11848	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		25025298	78151	39	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		CHEMBL2103855	78151	39	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		103	4153	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	4153	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	4153	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	4153	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	4153	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		3601	14503	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201349	14503	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		2762	3863	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	3863	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	3863	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	3863	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	3863	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5583	13044	51	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL119	13044	51	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		22530	56130	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1600878	56130	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1625607	56130	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		62867	3129	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		7557	3129	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL398880	3129	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01621	3129	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		9822750	78409	65	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL2111097	78409	65	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		25151352	140606	67	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	140606	67	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		1547484	940	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	940	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	940	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	940	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	940	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4167	14500	43	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	14500	43	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		40973	46035	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		CHEMBL1533	46035	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		4418	34222	85	None	-	6	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		CHEMBL142635	34222	85	None	-	6	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		3344	198318	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		CHEMBL576127	198318	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		242	470	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		9601226	102400	7	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	563	14	1	6	6.1	CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C	10.1038/s41467-023-40064-9
		CHEMBL3039598	102400	7	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	563	14	1	6	6.1	CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C	10.1038/s41467-023-40064-9
		138106885	166911	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
		36314	166911	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
		CHEMBL428647	166911	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
		3336	95001	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1405922	95001	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL254832	95001	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4601	206747	35	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201023	206747	35	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL900	206747	35	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		102	4127	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	4127	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	4127	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	4127	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	4127	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		25295	13620	37	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1194287	13620	37	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		9417	133512	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	133512	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	133512	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		11057	176149	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3468	176149	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL459265	176149	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL64894	176149	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		2585	803	103	None	-112	21	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	803	103	None	-112	21	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	803	103	None	-112	21	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	803	103	None	-112	21	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	803	103	None	-112	21	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		3117	207841	103	None	-2	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
		CHEMBL964	207841	103	None	-2	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
		1599	2341	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3955	2341	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7215	2341	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL841	2341	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00836	2341	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		135398737	958	93	None	-44	89	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-44	89	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-44	89	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-44	89	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-44	89	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		16564	204995	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		CHEMBL76725	204995	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		4417	55562	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1439099	55562	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1620794	55562	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL4744444	214034	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H]([C@H](C)CC(=O)O)C(=O)N[C@@H](CC(=O)c2ccccc2N)C(=O)O[C@@H]1C	10.1038/s41467-023-40064-9
		31101	729	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	729	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	729	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	729	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	729	40	None	-436	36	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		1613	2348	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	2348	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	2348	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	2348	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	2348	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3627	44129	18	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1515447	44129	18	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		93154	5436	29	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL107360	5436	29	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		16222096	80483	67	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		CHEMBL2146883	80483	67	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		1227	2489	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2331	2489	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		3957	2489	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		4992	2489	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL511	2489	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		DB06691	2489	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		5022	1651	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		6918248	1651	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		8182	1651	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL231068	1651	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		DB04908	1651	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		6077	150698	31	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	150698	31	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		3561	19077	39	None	-1	11	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1289	19077	39	None	-1	11	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		441383	20333	57	None	-12	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1306	20333	57	None	-12	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		259329	60504	31	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	519	7	2	4	5.3	C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O	10.1038/s41467-023-40064-9
		CHEMBL1756	60504	31	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	519	7	2	4	5.3	C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O	10.1038/s41467-023-40064-9
		2181	3128	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		4830	3128	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		92	3128	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL440294	3128	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		DB09286	3128	46	None	-	35	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL5291995	194536	0	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		4098	32505	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1255739	32505	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1411979	32505	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		1153	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		12668023	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026874	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026875	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		3341	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		6603851	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		933	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		939	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		985	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1160786	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1161520	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL588	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		DB00800	1628	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		4485	69379	118	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
		CHEMBL193	69379	118	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
		1190	882	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		25074887	882	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		583	882	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL1200490	882	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		DB00050	882	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		48041	107081	46	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
		CHEMBL315838	107081	46	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
		40	1547	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		77993	1547	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		995	1547	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1510	1547	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		DB00216	1547	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		37464	19221	26	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1290	19221	26	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		3584	3777	64	None	-	13	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	3777	64	None	-	13	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	3777	64	None	-	13	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	3777	64	None	-	13	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	3777	64	None	-	13	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		3158	56267	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		2237	3162	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		3634	3162	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		4887	3162	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		CHEMBL21333	3162	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		DB01411	3162	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		25025298	78151	39	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		CHEMBL2103855	78151	39	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		228	445	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		33	445	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		6005	445	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		CHEMBL53	445	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		DB00714	445	28	None	-35	24	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		9571107	167519	33	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		CHEMBL430	167519	33	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		2600	3779	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		150311	9812	102	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
		CHEMBL1138	9812	102	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
		2444	14478	26	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201245	14478	26	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		2799	39794	55	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	364	4	1	1	7.0	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1476605	39794	55	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	364	4	1	1	7.0	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1	10.1038/s41467-023-40064-9
		11154555	800	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5037	800	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		7671	800	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL2028019	800	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL3085826	800	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB06016	800	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		11976	920	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	920	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	920	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	920	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		2865	4143	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL4743867	214033	14	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		3158	56267	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	56267	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		277	1301	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2913	1301	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		765	1301	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL516	1301	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB00434	1301	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		1427	2013	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		357	2013	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3696	2013	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL11	2013	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00458	2013	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		15387	45822	55	None	-	24	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1531134	45822	55	None	-	24	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		2286	3183	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	3183	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	3183	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	3183	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	3183	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		124087	1389	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	1389	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	1389	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	1389	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	1389	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		2105	3054	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	3054	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	3054	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	3054	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	3054	37	None	-537	33	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		9571107	167519	33	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		CHEMBL430	167519	33	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		3678	94792	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL253371	94792	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		2335	11848	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	11848	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	11848	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	11848	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		54758501	139067	58	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		CHEMBL3786343	139067	58	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		71109	78206	10	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		CHEMBL2105453	78206	10	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		1971	2866	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2404	2866	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		4543	2866	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL445	2866	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		DB00540	2866	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2389	3331	118	None	-489	67	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-489	67	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-489	67	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-489	67	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-489	67	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		2771	195017	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		34040	28085	72	None	-	1	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		CHEMBL1372950	28085	72	None	-	1	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		2865	4143	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	4143	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	4143	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	4143	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	4143	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		2601	3780	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		443951	3780	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		56	3780	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL73151	3780	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB13399	3780	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		12555	17961	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL12610	17961	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		11167602	70460	116	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		CHEMBL1946170	70460	116	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		1548955	88581	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2800	88581	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2355051	88581	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		1212	1662	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		204	1662	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		3372	1662	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL726	1662	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00623	1662	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		25102847	78221	93	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		CHEMBL2105717	78221	93	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		1588	2325	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		28864	2325	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		43	2325	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL157138	2325	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB00589	2325	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		135398737	958	93	None	-44	89	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-44	89	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-44	89	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-44	89	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-44	89	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		180	401	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		193962	103793	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		CHEMBL308954	103793	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		1353	1911	93	None	-38	83	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-38	83	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-38	83	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-38	83	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-38	83	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3157	1470	71	None	-	10	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	1470	71	None	-	10	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	1470	71	None	-	10	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	1470	71	None	-	10	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	1470	71	None	-	10	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		5328940	100216	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	100216	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		135398737	958	93	None	-44	89	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	958	93	None	-44	89	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	958	93	None	-44	89	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	958	93	None	-44	89	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	958	93	None	-44	89	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		65772	60403	8	None	-	6	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL174984	60403	8	None	-	6	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		5329102	194726	86	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	194726	86	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		135	2532	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	2532	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	2532	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	2532	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	2532	43	None	-91	58	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		2683	102888	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL305906	102888	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL334255	102888	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		16362	3125	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	3125	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	3125	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	3125	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	3125	71	None	-52480	30	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		5351322	94791	38	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL25336	94791	38	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		65863	14465	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1201196	14465	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		115368	3056	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2112	3056	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		7556	3056	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1472975	3056	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		DB08922	3056	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		208898	66199	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		CHEMBL184412	66199	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		1086	1590	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		3290	1590	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		7181	1590	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		CHEMBL1206	1590	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		DB00392	1590	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		2337	3256	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		2726	919	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	919	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	919	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	919	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	919	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		448537	160250	89	None	-28	25	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	160250	89	None	-28	25	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		10531	1420	21	None	-218	23	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	1420	21	None	-218	23	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	1420	21	None	-218	23	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	1420	21	None	-218	23	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	1420	21	None	-218	23	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		4822	45032	47	None	-	1	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL152408	45032	47	None	-	1	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		2407	3372	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		59227	3372	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		941	3372	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1303	3372	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		DB05271	3372	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		49843517	78294	41	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		CHEMBL2107831	78294	41	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		25151352	140606	67	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	140606	67	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		11167602	70460	116	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		CHEMBL1946170	70460	116	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		10071196	3124	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		5142	3124	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		8423	3124	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		CHEMBL2111101	3124	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		DB05316	3124	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		71897	78248	19	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		CHEMBL2106537	78248	19	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		2805	161890	38	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL415087	161890	38	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		114948	60297	14	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		CHEMBL1743263	60297	14	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		16351	102730	47	None	-	6	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	102730	47	None	-	6	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		123879	3287	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		1910	3287	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		1911	3287	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		2354	3287	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		CHEMBL361812	3287	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		DB13036	3287	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		10180	98869	47	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL279014	98869	47	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		3598	187821	76	None	-	7	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL496	187821	76	None	-	7	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		37	778	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	778	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	778	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	778	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	778	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		1524	2181	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		197	2181	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		3822	2181	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		88	2181	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL51	2181	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB12465	2181	96	None	-79	52	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		242	470	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		21855	84246	42	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL22108	84246	42	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		5353853	17986	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9556529	17986	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1262	17986	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		2389	3331	118	None	-489	67	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-489	67	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-489	67	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-489	67	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-489	67	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		6077	150698	31	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	150698	31	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		3294	2006	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	2006	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	2006	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	2006	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	2006	111	None	-56	45	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		2710	84308	31	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL22150	84308	31	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		43082	60283	37	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1742452	60283	37	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		98941	46950	17	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL154126	46950	17	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		2107	3055	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		4747	3055	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		9216	3055	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL251940	3055	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB01608	3055	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5440	28724	37	None	-1	9	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	28724	37	None	-1	9	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		104903	56344	17	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1630578	56344	17	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		1712	2492	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4078	2492	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		7227	2492	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		CHEMBL1088	2492	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		DB00933	2492	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		2771	195017	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	195017	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	195017	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		2446	154653	57	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL399510	154653	57	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		681	1465	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		940	1465	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		947	1465	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL59	1465	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		DB00988	1465	72	None	-154	39	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		3103	41658	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1492	41658	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		135398745	2914	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	2914	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	2914	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	2914	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		212	3806	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	3806	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	3806	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	3806	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	3806	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		242	470	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	470	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	470	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	470	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	470	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		3952	1888	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5353646	1888	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5443	1888	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5702063	1888	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL1331786	1888	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL420	1888	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		2389	3331	118	None	-489	67	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	3331	118	None	-489	67	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	3331	118	None	-489	67	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	3331	118	None	-489	67	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	3331	118	None	-489	67	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		129893322	28618	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		4923	28618	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353897	28618	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		6178111	28618	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1377	28618	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		2337	3256	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	3256	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	3256	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	3256	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	3256	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		1209	1658	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	1658	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	1658	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	1658	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	1658	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		5591	157531	90	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		CHEMBL408	157531	90	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		3280	48449	28	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL1555736	48449	28	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		4209	3163	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	3163	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	3163	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	3163	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	3163	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	3163	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		3053	205134	95	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		CHEMBL780	205134	95	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		5205	78187	58	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL2104895	78187	58	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1630575	56343	0	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
		443869	78141	45	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2103761	78141	45	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		1353	1911	93	None	-38	83	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-38	83	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-38	83	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-38	83	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-38	83	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		2600	3779	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	3779	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	3779	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	3779	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	3779	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		180	401	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	401	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	401	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	401	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	401	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2580	78395	18	None	-	2	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL2110775	78395	18	None	-	2	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		4756	16649	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		CHEMBL1201022	16649	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		CHEMBL1242	16649	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		1153	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		12668023	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026874	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026875	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		3341	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		6603851	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		933	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		939	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		985	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1160786	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1161520	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL588	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		DB00800	1628	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		1353	1911	93	None	-38	83	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	1911	93	None	-38	83	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	1911	93	None	-38	83	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	1911	93	None	-38	83	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	1911	93	None	-38	83	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		135409453	3773	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	3773	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	3773	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		3783	14005	23	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL1197051	14005	23	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		6075	150108	42	None	-	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL395110	150108	42	None	-	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		4735	195115	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL361506	195115	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL55	195115	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		4034	55822	55	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	55822	55	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		2247	505	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	505	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	505	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	505	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	505	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		146025821	169671	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4437552	169671	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025821	169671	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4437552	169671	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025817	176017	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	176017	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025817	176017	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	176017	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146192964	174710	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4559891	174710	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		681	1465	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		940	1465	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		947	1465	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		CHEMBL59	1465	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		DB00988	1465	72	None	-154	39	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		6852376	91599	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		CHEMBL1467585	91599	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		CHEMBL24077	91599	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		CHEMBL503958	91599	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		11938	2412	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		146192952	2412	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4468760	2412	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		75201901	166425	19	None	-1	24	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-1	24	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		130442471	176084	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		CHEMBL4591207	176084	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		75201961	169630	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
		CHEMBL4437012	169630	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
		130442471	176084	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		CHEMBL4591207	176084	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		75201901	166425	19	None	-1	24	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-1	24	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		4901726	180799	9	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4756486	180799	9	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		12668019	10239	8	None	204	3	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
		CHEMBL1160787	10239	8	None	204	3	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
		6603820	95774	19	None	-4	13	Human	7.9	pEC50	=	7.9	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		CHEMBL25856	95774	19	None	-4	13	Human	7.9	pEC50	=	7.9	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		146025820	173222	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4523054	173222	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		681	1465	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		940	1465	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		947	1465	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		CHEMBL59	1465	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		DB00988	1465	72	None	-154	39	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		85090318	179445	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4740497	179445	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		146192966	175316	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acs.jmedchem.1c01887
		CHEMBL4573538	175316	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acs.jmedchem.1c01887
		85090319	180610	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4754602	180610	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090338	180761	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4756163	180761	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090320	182563	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4787728	182563	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090337	183281	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4796761	183281	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		11938	2412	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		146192952	2412	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4468760	2412	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		85090325	179749	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4744261	179749	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090334	180625	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4754761	180625	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		132016545	173076	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	333	2	0	1	4.7	C[C@H]1c2ccccc2CCN1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		CHEMBL4519818	173076	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	333	2	0	1	4.7	C[C@H]1c2ccccc2CCN1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		9796958	146578	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL2115374	146578	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL39230	146578	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL544814	146578	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		130442473	167337	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4294397	167337	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		130442473	167337	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4294397	167337	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		85090335	181114	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
		CHEMBL4760355	181114	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
		85090330	181073	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4759814	181073	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		167715	2876	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		969	2876	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL225230	2876	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		24133757	171600	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	340	1	1	2	5.2	CC1c2ccsc2CCN1C(=O)Nc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		CHEMBL4465320	171600	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	340	1	1	2	5.2	CC1c2ccsc2CCN1C(=O)Nc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		167715	2876	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		969	2876	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL225230	2876	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		133642	171951	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		CHEMBL4470553	171951	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		133642	171951	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		CHEMBL4470553	171951	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		10742	3617	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
		1225	3617	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
		CHEMBL35354	3617	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
		10020353	13889	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
		CHEMBL1196161	13889	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
		CHEMBL556024	13889	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
		85090328	181035	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4759339	181035	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		146025701	170571	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		CHEMBL4450338	170571	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		146025713	171611	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4465393	171611	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		146025701	170571	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		CHEMBL4450338	170571	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		146025713	171611	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4465393	171611	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		130442480	175270	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		130442480	175270	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		146025816	169978	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	169978	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		1242	3613	27	None	-5	18	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
		935	3613	27	None	-5	18	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
		CHEMBL286080	3613	27	None	-5	18	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
		146192967	191112	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	485	5	1	5	4.5	C[C@H]1c2cccc(-c3cnn(C4COC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL5187909	191112	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	485	5	1	5	4.5	C[C@H]1c2cccc(-c3cnn(C4COC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		146025816	169978	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	169978	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		130442590	169799	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4439333	169799	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		130442590	169799	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4439333	169799	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		130442572	171908	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		130442572	171908	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		6603703	208	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		9637	208	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		CHEMBL291143	208	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		1153	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		12668023	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		30026874	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		30026875	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		3341	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		6603851	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		933	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		939	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		985	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		CHEMBL1160786	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		CHEMBL1161520	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		CHEMBL588	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		DB00800	1628	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		75201901	166425	19	None	-1	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
		CHEMBL4277264	166425	19	None	-1	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
		2030130	20979	16	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL1311333	20979	16	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090324	180692	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4755481	180692	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		76284418	182318	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4784295	182318	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		75202022	170810	2	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		CHEMBL4453318	170810	2	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		146025815	169779	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	169779	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		1218	3616	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		938	3616	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		CHEMBL353335	3616	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		146025815	169779	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	169779	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		85090321	182813	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4790909	182813	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090323	181922	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4779641	181922	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
		146266	100698	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		CHEMBL292418	100698	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		CHEMBL540857	100698	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		146025823	169577	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		CHEMBL4435882	169577	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		146025823	169577	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		CHEMBL4435882	169577	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		85090322	179459	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4740678	179459	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		75201899	171916	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		CHEMBL4469983	171916	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		228	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		33	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		6005	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL53	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		DB00714	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		3033200	174527	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		CHEMBL4555547	174527	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		85090333	181301	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4762375	181301	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090326	182773	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4790277	182773	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		228	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		33	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		6005	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL53	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		DB00714	445	28	None	-35	24	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		3033200	174527	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		CHEMBL4555547	174527	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		85090332	180719	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4755709	180719	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		6852376	91599	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL1467585	91599	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL24077	91599	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL503958	91599	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		146192960	171519	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4464150	171519	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		85090339	182305	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
		CHEMBL4784143	182305	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
		136326241	179428	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4740312	179428	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		92044504	171727	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4467080	171727	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		92044504	171727	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4467080	171727	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		3045992	176075	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4591021	176075	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		90134269	174206	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4548284	174206	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		90134269	174206	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4548284	174206	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		3045992	176075	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4591021	176075	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		85090329	182682	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4789255	182682	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090331	181453	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4764398	181453	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		76284419	183248	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4796389	183248	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
		9841398	99519	4	None	-3	4	Human	8.1	pEC50	=	8.1	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		CHEMBL28338	99519	4	None	-3	4	Human	8.1	pEC50	=	8.1	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		1218	3616	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		938	3616	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		CHEMBL353335	3616	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		72548703	161567	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	161567	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		3036864	202754	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		CHEMBL1256645	202754	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		CHEMBL1814790	202754	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		CHEMBL62	202754	19	None	-2	28	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		3036864	202754	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1256645	202754	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1814790	202754	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL62	202754	19	None	-2	28	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		5281878	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		5281881	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		948	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		968	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		CHEMBL42055	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		CHEMBL54661	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		DB00875	1660	35	None	-11	17	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		5018	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		943	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		946	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		CHEMBL13668	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		5018	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		943	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		946	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		CHEMBL13668	3549	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		44358126	26679	0	None	-	0	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	315	1	1	2	4.2	C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm00022a004
		CHEMBL136190	26679	0	None	-	0	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	315	1	1	2	4.2	C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		CHEMBL62	202754	19	None	-2	28	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		11795296	26767	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136260	26767	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		CHEMBL1256645	202754	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		CHEMBL1814790	202754	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		CHEMBL62	202754	19	None	-2	28	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		10809333	27191	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136630	27191	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		10522247	26731	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136235	26731	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		CHEMBL1256645	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		CHEMBL1814790	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		CHEMBL62	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		10784787	26721	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	360	2	0	3	5.0	CN1CCN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136226	26721	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	360	2	0	3	5.0	CN1CCN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		11795296	26767	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136260	26767	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		CHEMBL1256645	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		CHEMBL1814790	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		CHEMBL62	202754	19	None	-2	28	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		10712649	119207	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL343282	119207	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		10810927	119296	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL343922	119296	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		10522247	26731	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136235	26731	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		11794473	119330	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCC2	10.1021/jm00022a004
		CHEMBL344206	119330	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCC2	10.1021/jm00022a004
		10810927	119296	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL343922	119296	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1256645	202754	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1814790	202754	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL62	202754	19	None	-2	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		10787324	26856	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	402	4	1	3	4.4	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCO	10.1021/jm00022a004
		CHEMBL136340	26856	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	402	4	1	3	4.4	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCO	10.1021/jm00022a004
		10574585	27425	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL136822	27425	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		CHEMBL62	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		3036864	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		CHEMBL62	202754	19	None	-2	28	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		10043978	27248	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136683	27248	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		10525990	27572	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	5	1	3	4.8	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCCO	10.1021/jm00022a004
		CHEMBL136932	27572	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	5	1	3	4.8	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCCO	10.1021/jm00022a004
		10247592	28904	1	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137960	28904	1	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		6603950	203324	9	None	-3	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		CHEMBL64875	203324	9	None	-3	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		6603950	203324	9	None	-3	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		CHEMBL64875	203324	9	None	-3	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		107995	97126	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
		29982233	97126	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
		CHEMBL267723	97126	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
		10809333	27191	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136630	27191	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		CHEMBL1256645	202754	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		CHEMBL1814790	202754	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		CHEMBL62	202754	19	None	-2	28	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		10712649	119207	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL343282	119207	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1256645	202754	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1814790	202754	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL62	202754	19	None	-2	28	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		10835172	119179	0	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	406	2	0	2	5.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL343078	119179	0	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	406	2	0	2	5.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1(C)C	10.1021/jm00022a004
		10247592	28904	1	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137960	28904	1	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		10525999	27363	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Br)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136776	27363	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Br)cc32)CC1(C)C	10.1021/jm00022a004
		10574585	27425	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL136822	27425	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		5016	109169	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL32145	109169	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL544114	109169	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
		146025812	174891	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4564103	174891	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		10049758	204645	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	457	2	0	7	3.7	CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL73589	204645	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	457	2	0	7	3.7	CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		177725	173266	2	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)C[C@H]1c3c(ccc(O)c3O2)CCN1C	10.1021/jm060959i
		CHEMBL452510	173266	2	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)C[C@H]1c3c(ccc(O)c3O2)CCN1C	10.1021/jm060959i
		159034	173267	3	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1ccc2c(c1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL452512	173267	3	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1ccc2c(c1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		15657216	12997	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1189682	12997	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL539274	12997	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		15657214	13238	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1191339	13238	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL542419	13238	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		10252000	98547	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27650	98547	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50188	98547	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		15065270	112356	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	249	2	1	4	2.5	CCCN1CCC2=C(CCc3sc(N)nc32)C1	10.1021/jm00113a010
		CHEMBL329444	112356	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	249	2	1	4	2.5	CCCN1CCC2=C(CCc3sc(N)nc32)C1	10.1021/jm00113a010
		194775	207319	27	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	223	3	1	4	2.2	CCCN1CCC=C(c2csc(N)n2)C1	10.1021/jm00113a010
		CHEMBL93428	207319	27	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	223	3	1	4	2.2	CCCN1CCC=C(c2csc(N)n2)C1	10.1021/jm00113a010
		10008463	11249	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178971	11249	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51985	11249	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		11743327	98702	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27763	98702	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		131001	98993	7	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27995	98993	7	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		10364722	99085	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	99085	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	99085	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		3082597	99559	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	99559	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9975915	99736	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL284912	99736	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10338595	162499	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL416747	162499	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10707563	28355	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	275	3	0	3	3.3	CCCN1CCCCC12COc1cccc(OC)c1C2	10.1021/jm950861w
		CHEMBL137478	28355	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	275	3	0	3	3.3	CCCN1CCCCC12COc1cccc(OC)c1C2	10.1021/jm950861w
		3082597	99559	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL283606	99559	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		14138285	145155	6	None	-	1	Human	6.0	pIC50	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		CHEMBL3912178	145155	6	None	-	1	Human	6.0	pIC50	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		71109989	153775	0	None	6	2	Human	7.0	pIC50	=	7.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3982119	153775	0	None	6	2	Human	7.0	pIC50	=	7.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		9992356	9756	1	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		CHEMBL113477	9756	1	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		440585	12691	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL1187468	12691	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL503882	12691	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
		135221	145219	5	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3912606	145219	5	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		135398737	958	93	None	-44	89	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-44	89	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-44	89	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-44	89	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-44	89	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		10015045	13652	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		CHEMBL119455	13652	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		6603799	99714	17	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL284746	99714	17	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		150	2509	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	2509	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	2509	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	2509	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	2509	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		14901831	13384	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1192581	13384	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL543838	13384	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		3168	9262	92	None	-89	21	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-89	21	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		16104	161917	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm991005d
		CHEMBL415300	161917	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm991005d
		16104	161917	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm9704457
		CHEMBL415300	161917	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm9704457
		6603820	95774	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		CHEMBL25856	95774	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		1353	1911	93	None	-38	83	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-38	83	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-38	83	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-38	83	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-38	83	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		10015045	13652	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL119455	13652	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		146025812	174891	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4564103	174891	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		10043978	27248	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136683	27248	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		14901827	13053	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1190039	13053	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL540036	13053	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		44584684	12442	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL1186001	12442	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL445011	12442	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		2398	954	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		44317479	205745	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.	ChEMBL	243	4	3	3	2.4	NCC(Cc1ccccc1)c1ccc(O)c(O)c1	10.1021/jm00013a015
		CHEMBL82706	205745	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.	ChEMBL	243	4	3	3	2.4	NCC(Cc1ccccc1)c1ccc(O)c(O)c1	10.1021/jm00013a015
		10885636	111016	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL326263	111016	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		10024827	13137	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1190552	13137	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL541096	13137	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		70684206	76065	0	None	11	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057442	76065	0	None	11	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692652	76064	0	None	8	2	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		CHEMBL2057441	76064	0	None	8	2	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		10547041	23814	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.8	Oc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		CHEMBL133615	23814	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.8	Oc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		14901829	13143	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1190633	13143	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL541304	13143	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		10264849	9367	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	265	0	1	2	3.3	CN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		CHEMBL111348	9367	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	265	0	1	2	3.3	CN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		107715	200945	22	None	-144	19	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	200945	22	None	-144	19	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	200945	22	None	-144	19	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		8447	188949	84	None	-8	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	188949	84	None	-8	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		3191	102858	97	None	-12	25	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-12	25	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		13154762	103110	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL307717	103110	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		15648961	107401	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	341	2	0	1	5.4	CN1CCC(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL317982	107401	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	341	2	0	1	5.4	CN1CCC(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		6603820	95774	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00168a034
		CHEMBL25856	95774	19	None	1	13	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00168a034
		6917970	3691	61	None	-1	34	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		8370	3691	61	None	-1	34	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		CHEMBL487387	3691	61	None	-1	34	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		6604005	157117	2	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm00168a034
		CHEMBL407489	157117	2	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm00168a034
		10361722	22220	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.5	Oc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		CHEMBL132304	22220	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.5	Oc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		10333742	59400	1	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	277	2	0	1	4.1	c1ccc(CN2CCCC3Cc4ccccc4CC32)cc1	10.1016/s0960-894x(01)00076-2
		CHEMBL170974	59400	1	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	277	2	0	1	4.1	c1ccc(CN2CCCC3Cc4ccccc4CC32)cc1	10.1016/s0960-894x(01)00076-2
		42	2063	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		56971	2063	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL8412	2063	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		42	2063	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
		56971	2063	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
		CHEMBL8412	2063	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
		44370646	48215	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@H](C2)N(C)CC3	10.1021/jm00164a022
		CHEMBL155246	48215	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@H](C2)N(C)CC3	10.1021/jm00164a022
		44269133	33935	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	356	2	3	3	2.1	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL14239	33935	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	356	2	3	3	2.1	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		72329	95648	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	337	2	2	5	4.0	COc1c(O)c2c3c(nccc3c1OC)C(C)(C)c1cc(O)ccc1-2	10.1021/jm060959i
		CHEMBL257958	95648	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	337	2	2	5	4.0	COc1c(O)c2c3c(nccc3c1OC)C(C)(C)c1cc(O)ccc1-2	10.1021/jm060959i
		64143	198864	62	None	-1	8	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		CHEMBL584	198864	62	None	-1	8	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		10523361	29825	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC(C)N1C	10.1021/jm00022a004
		CHEMBL138745	29825	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC(C)N1C	10.1021/jm00022a004
		10567738	119406	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	320	2	0	2	4.3	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL344680	119406	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	320	2	0	2	4.3	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		71109797	145896	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		CHEMBL3917753	145896	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		135398737	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		38	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		722	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		CHEMBL42	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		DB00363	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		15653096	207890	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
		CHEMBL1788129	207890	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
		CHEMBL96618	207890	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
		135398737	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		38	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		722	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		CHEMBL42	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		DB00363	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		135398737	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		38	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		722	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		CHEMBL42	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		DB00363	958	93	None	-83	89	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		100	3805	58	None	-16	55	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		2637	3805	58	None	-16	55	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		5452	3805	58	None	-16	55	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		CHEMBL479	3805	58	None	-16	55	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		DB00679	3805	58	None	-16	55	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		131213	5302	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL106622	5302	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		131213	5302	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL106622	5302	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		44312870	204577	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		CHEMBL73082	204577	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		44285576	142251	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C/c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		CHEMBL38848	142251	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C/c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		12545	47659	12	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	281	1	1	3	3.2	COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		CHEMBL154709	47659	12	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	281	1	1	3	3.2	COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		195158	43151	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		CHEMBL150550	43151	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		44267161	163042	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	456	10	0	5	4.4	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL417608	163042	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	456	10	0	5	4.4	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		70690498	76067	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057445	76067	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		71109805	87505	0	None	27	3	Human	7.8	pIC50	=	7.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		CHEMBL2334881	87505	0	None	27	3	Human	7.8	pIC50	=	7.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		70690500	76073	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	76073	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		70692653	76066	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057443	76066	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		70692653	76066	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL2057443	76066	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		146025817	176017	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	176017	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		22857296	29150	0	None	-	4	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13816	29150	0	None	-	4	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		146025817	176017	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	176017	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		15720219	68665	1	None	-	1	Rat	4.8	pIC50	=	4.8	Binding	Compound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranesCompound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranes	ChEMBL	220	5	0	2	2.9	CCCN(CCC)[C@H]1CCn2cccc2C1	10.1016/S0960-894X(00)80003-7
		CHEMBL192037	68665	1	None	-	1	Rat	4.8	pIC50	=	4.8	Binding	Compound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranesCompound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranes	ChEMBL	220	5	0	2	2.9	CCCN(CCC)[C@H]1CCn2cccc2C1	10.1016/S0960-894X(00)80003-7
		146025813	175587	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4579687	175587	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		6603820	95774	19	None	1	13	Rat	6.8	pIC50	=	6.8	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		CHEMBL25856	95774	19	None	1	13	Rat	6.8	pIC50	=	6.8	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		2585	803	103	None	-112	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	803	103	None	-112	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	803	103	None	-112	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	803	103	None	-112	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	803	103	None	-112	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		71474024	144468	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3906676	144468	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		10247592	28904	1	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137960	28904	1	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		146025816	169978	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	169978	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		146025816	169978	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	169978	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		44190762	176880	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from dopamine D1 receptorDisplacement of radioligand from dopamine D1 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		CHEMBL461571	176880	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from dopamine D1 receptorDisplacement of radioligand from dopamine D1 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		26987	949	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		9851833	12440	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL1185978	12440	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL443953	12440	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
		2274	3173	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44284723	138121	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C/C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL37661	138121	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C/C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		277	1301	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		146025815	169779	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	169779	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		15115476	27106	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	2	0	2	4.2	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		CHEMBL136553	27106	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	2	0	2	4.2	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		10320519	27115	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	4	1	3	3.2	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL136562	27115	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	4	1	3	3.2	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		146025815	169779	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	169779	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		10732779	188271	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	297	4	2	3	3.7	CCCN1CCc2cc(O)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm001128u
		CHEMBL49995	188271	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	297	4	2	3	3.7	CCCN1CCc2cc(O)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm001128u
		10264176	111326	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		CHEMBL326781	111326	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		10048240	13394	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1192639	13394	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL543914	13394	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		44358170	28287	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	378	2	0	2	4.7	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		CHEMBL137430	28287	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	378	2	0	2	4.7	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		100	3805	58	None	-16	55	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		2637	3805	58	None	-16	55	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		5452	3805	58	None	-16	55	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		CHEMBL479	3805	58	None	-16	55	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		DB00679	3805	58	None	-16	55	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		44370644	48801	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm060959i
		CHEMBL155884	48801	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm060959i
		240	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		2769	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		44279790	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		660	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		CHEMBL1729	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		CHEMBL560739	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		DB00604	944	43	None	-	24	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		44370644	48801	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		CHEMBL155884	48801	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		6603798	100180	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL1613539	100180	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL288096	100180	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		6603798	100180	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL1613539	100180	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL288096	100180	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		14140118	95596	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	1	4	3.2	COc1c(O)c2c3c(c1OC)CCN(C)C3Cc1ccccc1-2	10.1021/jm060959i
		CHEMBL257747	95596	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	1	4	3.2	COc1c(O)c2c3c(c1OC)CCN(C)C3Cc1ccccc1-2	10.1021/jm060959i
		1043	1582	14	None	-9549	28	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	1582	14	None	-9549	28	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	1582	14	None	-9549	28	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	1582	14	None	-9549	28	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	1582	14	None	-9549	28	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		1588	2325	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		15653097	207192	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		CHEMBL2111567	207192	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		CHEMBL92560	207192	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		9979207	13838	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1195842	13838	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL555427	13838	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		44370749	48739	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		CHEMBL155833	48739	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		70692652	76064	0	None	8	2	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057441	76064	0	None	8	2	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		6603729	99956	2	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL286424	99956	2	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@H](c2ccccc2)C1	10.1021/jm00086a016
		192611	13569	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1193985	13569	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL545477	13569	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		10595484	119090	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)C(C)CN1C	10.1021/jm00022a004
		CHEMBL342698	119090	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)C(C)CN1C	10.1021/jm00022a004
		71240	207717	14	None	-	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	408	4	1	3	4.0	OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00072a006
		CHEMBL95636	207717	14	None	-	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	408	4	1	3	4.0	OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00072a006
		1241	100179	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL288090	100179	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL552611	100179	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
		1242	3613	27	None	1	18	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
		935	3613	27	None	1	18	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
		CHEMBL286080	3613	27	None	1	18	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
		44269117	97313	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	352	2	2	4	3.2	CN1C[C@H](C(=O)Nc2nccs2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL269160	97313	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	352	2	2	4	3.2	CN1C[C@H](C(=O)Nc2nccs2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		10831881	116472	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	4.1	I/C=C/CN1CCC[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm980284m
		CHEMBL336128	116472	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	4.1	I/C=C/CN1CCC[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm980284m
		71474025	145327	0	None	131	2	Human	5.7	pIC50	=	5.7	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	145327	0	None	131	2	Human	5.7	pIC50	=	5.7	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		135398737	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		38	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		722	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		CHEMBL42	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		DB00363	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		135398737	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		38	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		722	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		CHEMBL42	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		DB00363	958	93	None	-83	89	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		100	3805	58	None	-47	55	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-47	55	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-47	55	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-47	55	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-47	55	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		129503	161668	10	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		CHEMBL413105	161668	10	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		2750	204061	76	None	-5	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	204061	76	None	-5	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		10043978	27248	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136683	27248	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		10641744	31328	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	352	2	0	2	4.7	Cc1ccc2c(c1)C(N1CCN(C)C(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL140189	31328	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	352	2	0	2	4.7	Cc1ccc2c(c1)C(N1CCN(C)C(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		10810109	115495	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	Fc1ccc(C2CC(N3CCN4CCCCC4C3)c3cc(Cl)ccc32)cc1	10.1021/jm00022a004
		CHEMBL335155	115495	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	Fc1ccc(C2CC(N3CCN4CCCCC4C3)c3cc(Cl)ccc32)cc1	10.1021/jm00022a004
		9819535	98947	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.	ChEMBL	344	2	1	4	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1	10.1016/0960-894X(96)00186-2
		CHEMBL279634	98947	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.	ChEMBL	344	2	1	4	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1	10.1016/0960-894X(96)00186-2
		2726	919	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		621	919	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		83	919	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		CHEMBL71	919	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		DB00477	919	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		12765746	102280	4	None	-8	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		CHEMBL303313	102280	4	None	-8	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		12765746	102280	4	None	-8	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		CHEMBL303313	102280	4	None	-8	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		1238	203174	24	None	-5	16	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		CHEMBL64249	203174	24	None	-5	16	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		12765746	102280	4	None	-8	9	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL303313	102280	4	None	-8	9	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		10666149	119332	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	0	2	4.7	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		CHEMBL344216	119332	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	0	2	4.7	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		10246528	27292	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136722	27292	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		3036864	202754	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1256645	202754	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1814790	202754	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL62	202754	19	None	-2	28	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		5018	3549	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		943	3549	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		946	3549	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		CHEMBL13668	3549	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		10810514	27216	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	392	2	1	2	5.1	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136648	27216	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	392	2	1	2	5.1	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CCN1	10.1021/jm00022a004
		135514603	204114	14	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	474	2	1	7	4.0	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL70319	204114	14	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	474	2	1	7	4.0	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		681	1465	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		940	1465	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		947	1465	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		CHEMBL59	1465	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		DB00988	1465	72	None	-23	39	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		15653098	207248	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1	10.1021/jm00022a004
		CHEMBL92896	207248	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1	10.1021/jm00022a004
		121852	10166	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	10166	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	10166	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9978353	11253	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL1178987	11253	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL52785	11253	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		9981024	96097	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	96097	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	96097	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10319624	98987	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27991	98987	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL298534	98987	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9980269	99083	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280586	99083	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54266	99083	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10321248	99426	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL28287	99426	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50722	99426	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		121852	10166	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL11592	10166	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL301060	10166	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		10333685	88544	3	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	276	1	1	1	3.8	CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		CHEMBL23529	88544	3	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	276	1	1	1	3.8	CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		14233815	207006	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CCC21	10.1021/jm00113a010
		CHEMBL91453	207006	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CCC21	10.1021/jm00113a010
		71109993	143247	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		CHEMBL3896617	143247	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		14547414	102284	1	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		CHEMBL303339	102284	1	None	-	5	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		28417	40039	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	40039	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		10480509	142331	0	None	-	2	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	483	2	2	5	4.4	COc1cc2c(c(Br)c1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL388564	142331	0	None	-	2	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	483	2	2	5	4.4	COc1cc2c(c(Br)c1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		44312605	204435	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL72162	204435	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		44323851	206974	0	None	3	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL91310	206974	0	None	3	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		13154801	27451	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	370	5	1	4	3.0	COc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL136841	27451	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	370	5	1	4	3.0	COc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		24121307	103043	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(C)(=O)=O)cc32)CC1	10.1021/jm991005d
		CHEMBL307163	103043	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(C)(=O)=O)cc32)CC1	10.1021/jm991005d
		3117	207841	103	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	207841	103	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		147080	205976	5	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.	ChEMBL	365	6	0	6	2.8	O=c1ccoc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc12	10.1021/jm00105a039
		CHEMBL84639	205976	5	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.	ChEMBL	365	6	0	6	2.8	O=c1ccoc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc12	10.1021/jm00105a039
		44354812	25129	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	3.8	I/C=C/CN1CCCC2Cc3ccccc3CC21	10.1021/jm980284m
		CHEMBL134746	25129	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	3.8	I/C=C/CN1CCCC2Cc3ccccc3CC21	10.1021/jm980284m
		44285034	149767	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C\C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL39483	149767	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C\C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		135493554	204160	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3cc(OS(C)(=O)=O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL70609	204160	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3cc(OS(C)(=O)=O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		125720	26315	5	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	338	2	2	3	1.7	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13588	26315	5	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	338	2	2	3	1.7	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		9911120	9623	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		CHEMBL11265	9623	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		2726	919	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		4913274	18000	2	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	408	4	1	3	4.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		CHEMBL12628	18000	2	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	408	4	1	3	4.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		15648962	108352	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	339	2	0	1	5.3	CN1CC=C(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL319810	108352	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	339	2	0	1	5.3	CN1CC=C(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		1212	1662	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		146025814	172779	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4513262	172779	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		9911120	9623	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		CHEMBL11265	9623	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		11744707	164909	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	454	6	0	5	4.3	COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		CHEMBL422283	164909	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	454	6	0	5	4.3	COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		228	445	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		33	445	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		6005	445	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		CHEMBL53	445	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		DB00714	445	28	None	-30	24	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		10400783	194885	0	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	267	2	1	3	2.8	c1ccc(C[C@@H]2NCCc3cc4c(cc32)OCO4)cc1	10.1021/jm001128u
		CHEMBL54051	194885	0	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	267	2	1	3	2.8	c1ccc(C[C@@H]2NCCc3cc4c(cc32)OCO4)cc1	10.1021/jm001128u
		10531	1420	21	None	-218	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	1420	21	None	-218	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	1420	21	None	-218	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	1420	21	None	-218	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	1420	21	None	-218	23	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		440989	95300	27	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	285	3	3	4	2.5	COc1cc2c(cc1O)[C@@H](Cc1ccc(O)cc1)NCC2	10.1021/np980008a
		CHEMBL256448	95300	27	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	285	3	3	4	2.5	COc1cc2c(cc1O)[C@@H](Cc1ccc(O)cc1)NCC2	10.1021/np980008a
		10408602	13696	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1194852	13696	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL553399	13696	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		2284	3182	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		10246528	27292	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136722	27292	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		22179	186265	42	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	3	5	2.5	COc1cc2c(cc1O)C[C@@H]1NCCc3cc(O)c(OC)c-2c31	10.1021/jm060959i
		CHEMBL487388	186265	42	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	3	5	2.5	COc1cc2c(cc1O)C[C@@H]1NCCc3cc(O)c(OC)c-2c31	10.1021/jm060959i
		11035765	9888	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	359	6	2	6	3.3	Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2	10.1021/jm010878g
		CHEMBL114280	9888	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	359	6	2	6	3.3	Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2	10.1021/jm010878g
		49836496	18555	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	246	2	1	1	3.5	CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1	10.1021/jm100515z
		CHEMBL1275791	18555	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	246	2	1	1	3.5	CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1	10.1021/jm100515z
		146025814	172779	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4513262	172779	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		197505	13691	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1194829	13691	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL553361	13691	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		441383	20333	57	None	-12	16	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	20333	57	None	-12	16	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		2600	3779	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	3779	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	3779	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	3779	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	3779	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		10762505	164857	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	4.1	COc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		CHEMBL421914	164857	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	4.1	COc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		2477	745	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		36	745	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		437	745	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL49	745	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		DB00490	745	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		44342270	9930	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		CHEMBL114484	9930	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		2286	3183	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		11730467	11028	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL117537	11028	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		11080	29085	79	None	-5	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	29085	79	None	-5	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		5352624	67239	44	None	-3	5	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		CHEMBL18797	67239	44	None	-3	5	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		2662	11384	131	None	-3	30	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		CHEMBL118	11384	131	None	-3	30	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		13154762	103110	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL307717	103110	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		6603997	99910	12	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL286120	99910	12	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00086a016
		15723883	206119	1	None	-	1	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	294	6	0	2	3.8	c1ccc(CCCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm00116a003
		CHEMBL85879	206119	1	None	-	1	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	294	6	0	2	3.8	c1ccc(CCCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm00116a003
		31101	729	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	729	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	729	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	729	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	729	40	None	-436	36	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		10264175	108601	1	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@@H]21	10.1021/jm00002a013
		CHEMBL320481	108601	1	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@@H]21	10.1021/jm00002a013
		196129	67798	17	None	-1819	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	67798	17	None	-1819	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		70684207	76070	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057452	76070	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70684207	76070	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057452	76070	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		14547415	100671	1	None	-	4	Rat	4.5	pIC50	=	4.5	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		CHEMBL292274	100671	1	None	-	4	Rat	4.5	pIC50	=	4.5	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		73453	29616	24	None	-208	17	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	29616	24	None	-208	17	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		195158	43151	1	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		CHEMBL150550	43151	1	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		21589014	144072	0	None	1	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3903297	144072	0	None	1	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		10246528	27292	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136722	27292	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		10004036	95229	0	None	33	2	Rat	8.5	pIC50	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL256075	95229	0	None	33	2	Rat	8.5	pIC50	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		10570260	28441	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(F)c32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137536	28441	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(F)c32)CC1(C)C	10.1021/jm00022a004
		70692655	76074	0	None	8	2	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057456	76074	0	None	8	2	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		15723897	9494	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	330	5	0	2	4.6	c1ccc(N2CCN(CCCc3ccc4ccccc4c3)CC2)cc1	10.1021/jm00116a003
		CHEMBL112037	9494	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	330	5	0	2	4.6	c1ccc(N2CCN(CCCc3ccc4ccccc4c3)CC2)cc1	10.1021/jm00116a003
		228	445	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		33	445	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		6005	445	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		CHEMBL53	445	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		DB00714	445	28	None	-30	24	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		681	1465	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		940	1465	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		947	1465	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		CHEMBL59	1465	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		DB00988	1465	72	None	-97	39	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		9861399	33297	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	307	2	0	2	4.9	CCN1CCc2c(sc3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		CHEMBL141863	33297	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	307	2	0	2	4.9	CCN1CCc2c(sc3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		10251234	11245	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	11245	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	11245	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10429859	12042	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL1183429	12042	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL296395	12042	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		10476735	13731	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1195096	13731	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL553833	13731	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9981024	96097	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	96097	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	96097	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		44312603	103773	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	350	1	0	2	4.9	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL308843	103773	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	350	1	0	2	4.9	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		14728694	5349	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	2	0	3	4.1	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/jm00174a002
		CHEMBL106886	5349	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	2	0	3	4.1	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/jm00174a002
		44319215	13204	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1191117	13204	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL542167	13204	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		11057	176149	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	176149	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	176149	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	176149	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		10809334	26847	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136334	26847	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1(C)C	10.1021/jm00022a004
		6761	67799	19	None	-5	18	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-5	18	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		44285043	154810	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C\c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		CHEMBL40031	154810	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C\c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		10043093	203859	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(Br)cc3CC[C@H]21	10.1021/jm00002a013
		CHEMBL68680	203859	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(Br)cc3CC[C@H]21	10.1021/jm00002a013
		70690497	76063	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057438	76063	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		70690497	76063	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL2057438	76063	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		13994412	11164	1	None	-117	3	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		CHEMBL117841	11164	1	None	-117	3	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		7055406	189343	3	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	299	4	2	4	2.8	COc1ccc(C[C@H]2NCCc3cc(O)c(OC)cc32)cc1	10.1021/np980008a
		CHEMBL512542	189343	3	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	299	4	2	4	2.8	COc1ccc(C[C@H]2NCCc3cc(O)c(OC)cc32)cc1	10.1021/np980008a
		9816455	16791	8	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@H]2CNC3	10.1021/jm0101545
		CHEMBL124561	16791	8	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@H]2CNC3	10.1021/jm0101545
		130907	194683	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL53294	194683	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		10091430	9881	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	384	7	1	4	3.3	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1	10.1016/0960-894X(96)00174-6
		CHEMBL11425	9881	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	384	7	1	4	3.3	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1	10.1016/0960-894X(96)00174-6
		457825	172654	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
		CHEMBL449690	172654	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
		CHEMBL506025	172654	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
		130907	194683	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL53294	194683	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		44370718	119540	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		CHEMBL345822	119540	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		1353	1911	93	None	-74	83	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		3559	1911	93	None	-74	83	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		86	1911	93	None	-74	83	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		DB00502	1911	93	None	-74	83	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		10548369	30445	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	388	2	0	2	5.6	CN1CCN(C2CC(c3ccc(Cl)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL139258	30445	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	388	2	0	2	5.6	CN1CCN(C2CC(c3ccc(Cl)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		9979258	98116	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	415	3	2	2	4.9	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL273526	98116	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	415	3	2	2	4.9	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		44267181	9611	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.	ChEMBL	277	7	0	3	3.4	CCCN(CCC)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL11262	9611	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.	ChEMBL	277	7	0	3	3.4	CCCN(CCC)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		6852376	91599	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		CHEMBL1467585	91599	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		CHEMBL24077	91599	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		CHEMBL503958	91599	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		44269085	24989	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13464	24989	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		180	401	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		1353	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		3559	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		86	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		CHEMBL54	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		DB00502	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		1353	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		3559	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		86	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		CHEMBL54	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		DB00502	1911	93	None	-74	83	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		164710	95595	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	4	2.5	Oc1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		CHEMBL257746	95595	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	4	2.5	Oc1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		736083	162214	17	None	-50	2	Rat	5.4	pIC50	=	5.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00164a022
		CHEMBL416288	162214	17	None	-50	2	Rat	5.4	pIC50	=	5.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00164a022
		10619325	27509	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136891	27509	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1(C)C	10.1021/jm00022a004
		71110290	147160	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3927835	147160	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		681	1465	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		940	1465	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		947	1465	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		CHEMBL59	1465	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		DB00988	1465	72	None	-97	39	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		4011	82408	49	None	-64	24	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-64	24	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		11005810	10466	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL116463	10466	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		44358128	27013	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	324	2	0	2	4.0	Cc1ccc2c(c1)C(N1CCN(C)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL136480	27013	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	324	2	0	2	4.0	Cc1ccc2c(c1)C(N1CCN(C)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		14901835	12915	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
		CHEMBL1189074	12915	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
		CHEMBL538012	12915	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
		10527884	28374	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	458	8	1	5	3.9	COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2	10.1021/jm950861w
		CHEMBL137486	28374	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	458	8	1	5	3.9	COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2	10.1021/jm950861w
		44269075	28619	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13770	28619	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		10550367	115207	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	426	7	1	4	4.2	COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2	10.1021/jm950861w
		CHEMBL334498	115207	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	426	7	1	4	4.2	COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2	10.1021/jm950861w
		228	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		33	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		6005	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		CHEMBL53	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		DB00714	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		228	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		33	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		6005	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		CHEMBL53	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		DB00714	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		228	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		33	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		6005	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		CHEMBL53	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		DB00714	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		2351	3286	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	3286	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	3286	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	3286	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	3286	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		12488	1657	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		13154803	116749	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	386	5	1	4	3.7	CSc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL337542	116749	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	386	5	1	4	3.7	CSc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		100231	177918	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL451211	177918	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL464525	177918	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
		191	403	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		121852	10166	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL11592	10166	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL301060	10166	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		10452020	118275	3	None	-	3	Rat	8.4	pIC50	=	8.4	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL34095	118275	3	None	-	3	Rat	8.4	pIC50	=	8.4	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		3036864	202754	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		CHEMBL1256645	202754	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		CHEMBL1814790	202754	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		CHEMBL62	202754	19	None	-2	28	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		3036864	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1256645	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1814790	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL62	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		3036864	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1256645	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1814790	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL62	202754	19	None	-2	28	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		10809335	26999	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccccc3F)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136468	26999	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccccc3F)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		70690500	76073	0	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057455	76073	0	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		3496768	95740	4	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	0	1	4	2.9	CN1CCc2cc3c(c4c2C1Cc1cccc(O)c1-4)OCO3	10.1021/jm060959i
		CHEMBL258370	95740	4	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	0	1	4	2.9	CN1CCc2cc3c(c4c2C1Cc1cccc(O)c1-4)OCO3	10.1021/jm060959i
		10154	142129	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL388342	142129	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		10154	142129	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL388342	142129	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		9981671	14541	0	None	-	1	Rat	6.4	pIC50	=	6.4	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	459	7	1	9	3.1	COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		CHEMBL12028	14541	0	None	-	1	Rat	6.4	pIC50	=	6.4	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	459	7	1	9	3.1	COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		121852	10166	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	10166	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	10166	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10251234	11245	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	11245	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	11245	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10047322	97140	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL26783	97140	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL50993	97140	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		10251673	99490	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283207	99490	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52396	99490	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10070029	165417	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL423841	165417	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54089	165417	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10265863	193324	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		CHEMBL52438	193324	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		121852	10166	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL11592	10166	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL301060	10166	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		2247	505	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		134551	358	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	358	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	358	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	358	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		146025811	171761	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4467483	171761	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025811	171761	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4467483	171761	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		5353853	17986	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	17986	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	17986	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		10498684	31639	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	359	3	2	2	3.6	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL14048	31639	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	359	3	2	2	3.6	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		71474079	143264	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3896731	143264	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		2337	3256	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		11016	203607	38	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	173	3	0	1	0.0	O=P(N1CC1)(N1CC1)N1CC1	10.1021/jm980284m
		CHEMBL670	203607	38	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	173	3	0	1	0.0	O=P(N1CC1)(N1CC1)N1CC1	10.1021/jm980284m
		228	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		33	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		6005	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		CHEMBL53	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		DB00714	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		228	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		33	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		6005	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		CHEMBL53	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		DB00714	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		332915	29718	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	240	0	1	1	3.1	C[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL13866	29718	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	240	0	1	1	3.1	C[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		10712649	119207	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL343282	119207	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		5353432	97495	89	None	-1	3	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		CHEMBL270299	97495	89	None	-1	3	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		44323870	111591	0	None	3	4	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL328246	111591	0	None	3	4	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		228	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		33	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		6005	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		CHEMBL53	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		DB00714	445	28	None	-30	24	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		9864292	30108	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL138964	30108	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1(C)C	10.1021/jm00022a004
		70682088	76068	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057446	76068	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		14004813	59284	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	307	3	0	2	4.1	COc1cccc2c1CC1CCCN(Cc3ccccc3)C1C2	10.1016/s0960-894x(01)00076-2
		CHEMBL170475	59284	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	307	3	0	2	4.1	COc1cccc2c1CC1CCCN(Cc3ccccc3)C1C2	10.1016/s0960-894x(01)00076-2
		CHEMBL1200633	208600	3	None	-7	8	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		44269057	31343	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	412	2	3	3	3.4	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL14020	31343	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	412	2	3	3	3.4	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		71110293	143379	0	None	6	3	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	143379	0	None	6	3	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		2389	3331	118	None	-489	67	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-489	67	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-489	67	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-489	67	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-489	67	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		44358098	119284	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	292	2	0	2	3.5	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		CHEMBL343820	119284	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	292	2	0	2	3.5	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		133381	95594	9	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	4	2.8	COc1c2c3c(c4c1OCO4)-c1ccccc1C[C@H]3NCC2	10.1021/jm060959i
		CHEMBL257745	95594	9	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	4	2.8	COc1c2c3c(c4c1OCO4)-c1ccccc1C[C@H]3NCC2	10.1021/jm060959i
		71110293	143379	0	None	6	3	Human	6.3	pIC50	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	143379	0	None	6	3	Human	6.3	pIC50	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		71474026	154299	0	None	1	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		CHEMBL3986624	154299	0	None	1	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		45482789	198925	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		CHEMBL584554	198925	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		5024	119250	25	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	297	3	0	3	3.3	COc1cc2c(cc1OC)C(c1ccccc1)CN(C)CC2	10.1021/jm980156y
		CHEMBL343569	119250	25	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	297	3	0	3	3.3	COc1cc2c(cc1OC)C(c1ccccc1)CN(C)CC2	10.1021/jm980156y
		10742	3617	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
		1225	3617	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
		CHEMBL35354	3617	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
		13154762	103110	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL307717	103110	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		6603820	95774	19	None	1	13	Rat	8.3	pIC50	=	8.3	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		CHEMBL25856	95774	19	None	1	13	Rat	8.3	pIC50	=	8.3	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		10617001	31155	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	1	2	4.4	Cc1ccc2c(c1)C(N1CCNC(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL140032	31155	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	1	2	4.4	Cc1ccc2c(c1)C(N1CCNC(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		6852376	91599	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL1467585	91599	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL24077	91599	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL503958	91599	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		11794523	30238	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	385	2	0	2	5.7	CCN1CCc2c(sc3ccccc23)C(c2cccc(Br)c2)C1	10.1021/jm980156y
		CHEMBL139081	30238	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	385	2	0	2	5.7	CCN1CCc2c(sc3ccccc23)C(c2cccc(Br)c2)C1	10.1021/jm980156y
		10712993	118748	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	352	3	0	4	4.8	CCN1CCc2c(sc3ccccc23)C(c2cccc([N+](=O)[O-])c2)C1	10.1021/jm980156y
		CHEMBL341805	118748	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	352	3	0	4	4.8	CCN1CCc2c(sc3ccccc23)C(c2cccc([N+](=O)[O-])c2)C1	10.1021/jm980156y
		10251234	11245	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	11245	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	11245	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10364722	99085	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	99085	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	99085	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10072866	197475	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51561	197475	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL56990	197475	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		11099480	189145	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1ccc2c(c1O)Oc1c(OC)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL510777	189145	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1ccc2c(c1O)Oc1c(OC)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		44370629	51059	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		CHEMBL157879	51059	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		10246432	13801	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1195595	13801	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL554950	13801	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		44379650	120757	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL355107	120757	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		10574585	27425	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL136822	27425	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		13154795	28900	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	4	1	3	3.3	Cc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL137954	28900	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	4	1	3	3.3	Cc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		10582557	194730	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	309	4	0	3	4.0	CCCN1CCc2cc3c(cc2[C@@H]1Cc1ccccc1)OCO3	10.1021/jm001128u
		CHEMBL53520	194730	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	309	4	0	3	4.0	CCCN1CCc2cc3c(cc2[C@@H]1Cc1ccccc1)OCO3	10.1021/jm001128u
		11795296	26767	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136260	26767	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		10424479	108868	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	293	2	1	2	4.1	CCCN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		CHEMBL321040	108868	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	293	2	1	2	4.1	CCCN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		10923047	16509	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@@H]2CNC3	10.1021/jm0101545
		CHEMBL123642	16509	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@@H]2CNC3	10.1021/jm0101545
		1971	2866	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		44312870	204577	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL73082	204577	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		44323876	206582	0	None	2	4	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL88870	206582	0	None	2	4	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		135	2532	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-91	58	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		10828627	103164	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm991005d
		CHEMBL308090	103164	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm991005d
		15521599	204538	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm991005d
		CHEMBL72794	204538	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm991005d
		10828627	103164	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm9704457
		CHEMBL308090	103164	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm9704457
		15521599	204538	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm9704457
		CHEMBL72794	204538	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm9704457
		10264174	9688	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@H]21	10.1021/jm00002a013
		CHEMBL113053	9688	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@H]21	10.1021/jm00002a013
		70692656	76075	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057457	76075	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692656	76075	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057457	76075	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		10031670	12464	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL1186148	12464	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL451734	12464	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
		44370651	46750	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1c(Cl)ccc(O)c1-3	10.1021/jm00164a022
		CHEMBL153960	46750	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1c(Cl)ccc(O)c1-3	10.1021/jm00164a022
		3561	19077	39	None	-1	11	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	19077	39	None	-1	11	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		14137099	172691	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
		CHEMBL450147	172691	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
		CHEMBL507970	172691	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
		44269131	30911	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	381	2	2	4	3.2	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13979	30911	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	381	2	2	4	3.2	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		71041800	162741	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	290	7	3	6	2.2	CCC[C@@H](CCO)Nc1nc(N)nc2cc(OC)ccc12	10.1021/acs.jmedchem.8b00643
		CHEMBL4171368	162741	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	290	7	3	6	2.2	CCC[C@@H](CCO)Nc1nc(N)nc2cc(OC)ccc12	10.1021/acs.jmedchem.8b00643
		44285013	153740	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	319	7	0	1	5.4	C(=C\C1CCCN(CCCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL39818	153740	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	319	7	0	1	5.4	C(=C\C1CCCN(CCCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		1042	1581	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	1581	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	1581	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	1581	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	1581	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		10693049	119368	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	412	2	0	2	6.0	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCCC2	10.1021/jm00022a004
		CHEMBL344426	119368	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	412	2	0	2	6.0	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCCC2	10.1021/jm00022a004
		10810927	119296	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL343922	119296	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		146299	173377	8	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL452776	173377	8	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		44267790	15523	0	None	-	1	Rat	6.2	pIC50	=	6.2	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	431	6	1	10	1.9	Cc1sc2nc(SCCCN3CCN(c4ncccn4)CC3)n(N)c(=O)c2c1C	10.1021/jm950866t
		CHEMBL12177	15523	0	None	-	1	Rat	6.2	pIC50	=	6.2	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	431	6	1	10	1.9	Cc1sc2nc(SCCCN3CCN(c4ncccn4)CC3)n(N)c(=O)c2c1C	10.1021/jm950866t
		118731187	118179	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	613	10	3	7	6.1	CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1/C=C/C(=O)O	10.1016/j.bmcl.2014.12.078
		CHEMBL3408841	118179	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	613	10	3	7	6.1	CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1/C=C/C(=O)O	10.1016/j.bmcl.2014.12.078
		10092409	12046	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1183479	12046	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL299561	12046	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10095594	12368	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1185501	12368	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL417550	12368	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10364722	99085	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	99085	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	99085	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL3215298	211231	13	None	-6	2	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		14901811	13537	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1193777	13537	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL545240	13537	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
		10809333	27191	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136630	27191	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		4189	206922	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		16104	161917	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00130a006
		CHEMBL415300	161917	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00130a006
		16104	161917	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00164a053
		CHEMBL415300	161917	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00164a053
		44285030	132490	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	291	5	0	1	4.7	C(=C\C1CCCN(CCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL36979	132490	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	291	5	0	1	4.7	C(=C\C1CCCN(CCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		23930365	95647	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c3c(c1OC)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1021/jm060959i
		CHEMBL257957	95647	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c3c(c1OC)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1021/jm060959i
		44370725	119552	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(Cl)c(O)c1-3	10.1021/jm00164a022
		CHEMBL345907	119552	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(Cl)c(O)c1-3	10.1021/jm00164a022
		9954899	204463	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL72292	204463	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		9954899	204463	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
		CHEMBL72292	204463	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
		167715	2876	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		969	2876	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		CHEMBL225230	2876	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		71109986	150633	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		CHEMBL3955446	150633	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		9904738	101656	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	309	2	2	3	3.8	CCCN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		CHEMBL299161	101656	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	309	2	2	3	3.8	CCCN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		13154798	26770	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	382	5	1	3	4.1	CC(C)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL136262	26770	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	382	5	1	3	4.1	CC(C)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		10026300	167834	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL430798	167834	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		10409038	85242	0	None	-41	4	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL225853	85242	0	None	-41	4	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		3081681	98514	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissuecompound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue	ChEMBL	442	6	0	7	3.4	O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1	10.1021/jm00107a028
		CHEMBL276175	98514	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissuecompound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue	ChEMBL	442	6	0	7	3.4	O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1	10.1021/jm00107a028
		5249490	15158	1	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1C2CNC3	10.1021/jm0101545
		CHEMBL120995	15158	1	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1C2CNC3	10.1021/jm0101545
		2105	3054	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	3054	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	3054	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	3054	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	3054	37	None	-537	33	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		70690499	76071	0	None	9	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057453	76071	0	None	9	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		160597	155075	30	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	3	2.8	c1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		CHEMBL401798	155075	30	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	3	2.8	c1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		70682090	76069	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057451	76069	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70682090	76069	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057451	76069	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		3158	56267	27	None	-2398	20	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-2398	20	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		2601	3780	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		443951	3780	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		56	3780	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		CHEMBL73151	3780	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		DB13399	3780	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		13154822	30491	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	418	5	1	5	2.4	CS(=O)(=O)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL139304	30491	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	418	5	1	5	2.4	CS(=O)(=O)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		6603820	95774	19	None	1	13	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		CHEMBL25856	95774	19	None	1	13	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		71474025	145327	0	None	131	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	145327	0	None	131	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		11539632	70561	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		CHEMBL194837	70561	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		44354823	24574	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	241	1	1	2	2.2	C#CCN1CCCC2Cc3c(O)cccc3CC21	10.1021/jm980284m
		CHEMBL134273	24574	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	241	1	1	2	2.2	C#CCN1CCCC2Cc3c(O)cccc3CC21	10.1021/jm980284m
		16038374	94347	95	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptorDisplacement of [3H]SCH-23390 from dopamine D1 receptor	ChEMBL	357	5	1	4	4.9	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1	10.1073/pnas.0611364104
		CHEMBL250699	94347	95	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptorDisplacement of [3H]SCH-23390 from dopamine D1 receptor	ChEMBL	357	5	1	4	4.9	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1	10.1073/pnas.0611364104
		10571551	116567	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	375	2	0	2	6.2	CCN1CCc2c(sc3ccccc23)C(c2ccc(Cl)c(Cl)c2)C1	10.1021/jm980156y
		CHEMBL336437	116567	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	375	2	0	2	6.2	CCN1CCc2c(sc3ccccc23)C(c2ccc(Cl)c(Cl)c2)C1	10.1021/jm980156y
		135398745	2914	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		49836386	18550	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	253	2	1	2	3.2	CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1	10.1021/jm100515z
		CHEMBL1275709	18550	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	253	2	1	2	3.2	CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1	10.1021/jm100515z
		44269142	32129	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL14089	32129	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		15115475	26845	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	322	4	1	3	2.9	OCCN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		CHEMBL136333	26845	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	322	4	1	3	2.9	OCCN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		12441	51091	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm00164a022
		CHEMBL157912	51091	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm00164a022
		44269091	98421	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL275539	98421	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		44312604	204451	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	338	1	0	2	4.6	CC1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL72220	204451	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	338	1	0	2	4.6	CC1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		133	2496	52	None	-30	42	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-30	42	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-30	42	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-30	42	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-30	42	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		12441	51091	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm060959i
		CHEMBL157912	51091	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm060959i
		5018	3549	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		943	3549	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		946	3549	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		CHEMBL13668	3549	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		135686415	204576	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm991005d
		CHEMBL73074	204576	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm991005d
		135686415	204576	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm9704457
		CHEMBL73074	204576	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm9704457
		3294	2006	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		71360	2006	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		87	2006	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		CHEMBL14376	2006	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		DB04946	2006	111	None	-	45	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		10144	138410	46	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	275	0	0	4	3.2	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3	10.1021/jm060959i
		CHEMBL37736	138410	46	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	275	0	0	4	3.2	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3	10.1021/jm060959i
		44269092	29086	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	296	0	1	1	4.4	C[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL13811	29086	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	296	0	1	1	4.4	C[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		11059058	10091	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
		CHEMBL115444	10091	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
		71110287	146325	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3921127	146325	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		448537	160250	89	None	-28	25	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	160250	89	None	-28	25	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		44312605	204435	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		CHEMBL72162	204435	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		13720693	99673	4	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL284473	99673	4	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		71109897	87513	0	None	7	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		CHEMBL2334893	87513	0	None	7	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		10478809	164878	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		CHEMBL422067	164878	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		10787201	28732	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	4	0	2	5.9	CCC1(CC)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		CHEMBL137805	28732	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	4	0	2	5.9	CCC1(CC)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		44354809	116542	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	3.8	COc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		CHEMBL336274	116542	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	3.8	COc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		100	3805	58	None	-16	55	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		2637	3805	58	None	-16	55	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		5452	3805	58	None	-16	55	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		CHEMBL479	3805	58	None	-16	55	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		DB00679	3805	58	None	-16	55	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		681	1465	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		940	1465	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		947	1465	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		CHEMBL59	1465	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		DB00988	1465	72	None	-97	39	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		442203	174558	5	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1cc2c(cc1OC)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL455633	174558	5	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1cc2c(cc1OC)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		10504100	47740	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane	ChEMBL	458	7	1	8	4.2	COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		CHEMBL154787	47740	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane	ChEMBL	458	7	1	8	4.2	COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		14901825	13088	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1190275	13088	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL540546	13088	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		10024943	97390	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26975	97390	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52485	97390	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10406315	193325	0	None	-	2	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	361	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(Cl)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL524439	193325	0	None	-	2	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	361	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(Cl)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		146025813	175587	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4579687	175587	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		44370706	47972	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1cc(Br)cc(O)c1-3	10.1021/jm00164a022
		CHEMBL154989	47972	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1cc(Br)cc(O)c1-3	10.1021/jm00164a022
		10409556	162372	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	414	8	1	5	3.3	COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1016/0960-894X(96)00174-6
		CHEMBL416523	162372	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	414	8	1	5	3.3	COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1016/0960-894X(96)00174-6
		15657207	206337	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	287	2	2	2	3.7	CNC1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL87321	206337	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	287	2	2	2	3.7	CNC1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00069a013
		44269058	31366	0	None	-	1	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL14022	31366	0	None	-	1	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		1016	3747	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		44370645	119562	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		CHEMBL346017	119562	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		1530	2182	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		10522247	26731	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136235	26731	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		16103	204638	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00130a006
		CHEMBL73538	204638	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00130a006
		16103	204638	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00164a053
		CHEMBL73538	204638	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00164a053
		71454427	78520	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		CHEMBL2111937	78520	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		44329358	107524	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL318714	107524	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		10833129	27490	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3cccc(F)c3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136873	27490	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3cccc(F)c3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		15648963	16894	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	340	2	0	2	5.1	CN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1	10.1021/jm00072a006
		CHEMBL12507	16894	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	340	2	0	2	5.1	CN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1	10.1021/jm00072a006
		70690500	76073	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	76073	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		9804849	67456	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		CHEMBL189118	67456	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		2812	4779	101	None	-32	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-32	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		44584686	12692	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL1187479	12692	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL504303	12692	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		11543723	189099	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		CHEMBL51017	189099	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		176	398	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		3198	205513	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		114876	12793	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
		CHEMBL1188090	12793	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
		CHEMBL545783	12793	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
		135515198	104750	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL310712	104750	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		135515198	104750	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		CHEMBL310712	104750	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		134	2514	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	2514	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	2514	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	2514	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	2514	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		11778475	163295	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3ccc(O)c(O)c3CC[C@H]21	10.1021/jm00002a013
		CHEMBL418791	163295	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3ccc(O)c(O)c3CC[C@H]21	10.1021/jm00002a013
		66572162	75695	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	363	6	1	3	5.2	OC(CCN1CC=C(Cc2ccccc2)CC1)c1cc2ccccc2s1	10.1016/j.ejmech.2012.04.030
		CHEMBL2047561	75695	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	363	6	1	3	5.2	OC(CCN1CC=C(Cc2ccccc2)CC1)c1cc2ccccc2s1	10.1016/j.ejmech.2012.04.030
		10907460	9828	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL113956	9828	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		25053021	109672	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL322574	109672	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		25053021	109672	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL322574	109672	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		70686343	76072	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057454	76072	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		135508767	204125	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL70377	204125	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		13891896	188931	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	297	2	2	4	2.8	COc1c(O)c2c3c(c1OC)CCN[C@@H]3Cc1ccccc1-2	10.1021/jm060959i
		CHEMBL508011	188931	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	297	2	2	4	2.8	COc1c(O)c2c3c(c1OC)CCN[C@@H]3Cc1ccccc1-2	10.1021/jm060959i
		135508767	204125	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		CHEMBL70377	204125	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		3082777	168322	10	None	-	1	Human	9.8	pKd	=	9.8	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2C(c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00119a003
		CHEMBL434215	168322	10	None	-	1	Human	9.8	pKd	=	9.8	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2C(c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00119a003
		164612037	185377	0	None	-144	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	185377	0	None	-144	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		168290235	192968	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168294767	193019	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168295528	193031	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		44366049	43455	0	None	-	1	Human	9.6	pKd	=	9.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		CHEMBL150800	43455	0	None	-	1	Human	9.6	pKd	=	9.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		2869	4152	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		60	4152	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		60857	4152	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		CHEMBL1185	4152	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		DB00315	4152	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		3036864	202754	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		CHEMBL1256645	202754	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		CHEMBL1814790	202754	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		CHEMBL62	202754	19	None	-2	28	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		129244	118671	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL2114388	118671	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL34170	118671	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		118736406	118956	0	None	3	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	673	16	7	7	2.7	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423404	118956	0	None	3	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	673	16	7	7	2.7	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		16731521	85455	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	630	10	4	5	3.5	CC(C)[C@H](NC(=O)[C@H](CCC1CCCCC1)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL226639	85455	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	630	10	4	5	3.5	CC(C)[C@H](NC(=O)[C@H](CCC1CCCCC1)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		118736409	118959	0	None	-1	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	693	16	6	6	3.3	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423407	118959	0	None	-1	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	693	16	6	6	3.3	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		6852376	91599	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		CHEMBL1467585	91599	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		CHEMBL24077	91599	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		CHEMBL503958	91599	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		118736412	118963	0	None	-6	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423410	118963	0	None	-6	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736405	118955	0	None	-9	3	Human	4.8	pKd	=	4.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423403	118955	0	None	-9	3	Human	4.8	pKd	=	4.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736413	118964	0	None	-2	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423411	118964	0	None	-2	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		167715	2876	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		969	2876	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		CHEMBL225230	2876	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		1153	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		12668023	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026874	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026875	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		3341	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		6603851	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		933	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		939	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		985	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1160786	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1161520	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL588	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		DB00800	1628	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		118736408	118958	0	None	1	3	Human	5.7	pKd	=	5.7	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	696	16	7	6	3.5	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423406	118958	0	None	1	3	Human	5.7	pKd	=	5.7	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	696	16	7	6	3.5	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		5311428	100107	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1744078	100107	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL287504	100107	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		10088113	162277	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1744079	162277	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL416401	162277	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		118736412	118963	0	None	-6	2	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423410	118963	0	None	-6	2	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		681	1465	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		940	1465	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		947	1465	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		CHEMBL59	1465	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		DB00988	1465	72	None	-154	39	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		118736402	118952	0	None	-5	4	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	659	11	5	6	2.4	CCCC[C@H](NC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423400	118952	0	None	-5	4	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	659	11	5	6	2.4	CCCC[C@H](NC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		1153	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		12668023	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026874	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026875	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		3341	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		6603851	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		933	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		939	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		985	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1160786	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1161520	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL588	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		DB00800	1628	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		118736404	118954	0	None	-2	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	18	7	7	3.5	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423402	118954	0	None	-2	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	18	7	7	3.5	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736413	118964	0	None	-2	2	Human	4.5	pKd	=	4.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423411	118964	0	None	-2	2	Human	4.5	pKd	=	4.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736411	118961	0	None	-1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	788	22	7	7	3.8	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423409	118961	0	None	-1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	788	22	7	7	3.8	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736407	118957	0	None	1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	17	7	7	3.5	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423405	118957	0	None	1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	17	7	7	3.5	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		118736403	118953	0	None	-6	3	Human	4.4	pKd	=	4.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	786	22	8	8	3.4	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423401	118953	0	None	-6	3	Human	4.4	pKd	=	4.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	786	22	8	8	3.4	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		10452020	118275	3	None	10	3	Human	6.4	pKd	=	6.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm950447w
		CHEMBL34095	118275	3	None	10	3	Human	6.4	pKd	=	6.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm950447w
		118736410	118960	0	None	-1	3	Human	5.4	pKd	=	5.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	772	17	6	7	3.1	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423408	118960	0	None	-1	3	Human	5.4	pKd	=	5.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	772	17	6	7	3.1	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		122132	202564	17	None	-87	4	Human	5.3	pKd	=	5.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm950447w
		CHEMBL611801	202564	17	None	-87	4	Human	5.3	pKd	=	5.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm950447w
		1960	2857	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		439260	2857	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		505	2857	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		CHEMBL1437	2857	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		DB00368	2857	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		1028	291	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		139148732	291	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		479	291	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		5816	291	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		CHEMBL679	291	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		DB00668	291	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		16731518	142282	0	None	26	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	628	9	4	5	2.5	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL388509	142282	0	None	26	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	628	9	4	5	2.5	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		228	445	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		33	445	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		6005	445	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		CHEMBL53	445	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		DB00714	445	28	None	-35	24	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		16732431	144031	0	None	-34	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	735	11	4	7	3.3	CN1C[C@H](C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCCC(C(N)=O)C2)C=C2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm060947x
		CHEMBL390299	144031	0	None	-34	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	735	11	4	7	3.3	CN1C[C@H](C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCCC(C(N)=O)C2)C=C2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm060947x
		16732899	168705	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL436797	168705	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		16731520	142351	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL388732	142351	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		5	139	72	None	-23442	54	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		5202	139	72	None	-23442	54	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		CHEMBL39	139	72	None	-23442	54	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		DB08839	139	72	None	-23442	54	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		4350931	169313	44	None	63	7	Rat	10.1	pKi	=	10.1	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		CHEMBL441618	169313	44	None	63	7	Rat	10.1	pKi	=	10.1	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		127026236	138118	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3763331	138118	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3765893	138118	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		3036864	202754	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	202754	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	202754	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	202754	19	None	-26	28	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		3036864	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		CHEMBL1256645	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		CHEMBL1814790	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		CHEMBL62	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		3036864	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		CHEMBL1256645	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		CHEMBL1814790	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		CHEMBL62	202754	19	None	-2	28	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		3036864	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1256645	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1814790	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL62	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		3036864	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		CHEMBL1256645	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		CHEMBL1814790	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		CHEMBL62	202754	19	None	-2	28	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		3036864	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL62	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		11465618	102398	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
		CHEMBL3039528	102398	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
		CHEMBL5191141	102398	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
		3036864	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		CHEMBL62	202754	19	None	-2	28	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		3036864	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		3036864	202754	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	202754	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	202754	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	202754	19	None	-26	28	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		3036864	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1256645	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1814790	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL62	202754	19	None	-2	28	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		3036864	202754	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		CHEMBL1256645	202754	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		CHEMBL1814790	202754	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		CHEMBL62	202754	19	None	-2	28	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		11154178	200226	0	None	64	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
		CHEMBL596824	200226	0	None	64	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
		162657549	180984	0	None	630	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	355	1	1	3	5.3	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4758723	180984	0	None	630	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	355	1	1	3	5.3	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		46231926	200579	0	None	12	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL599135	200579	0	None	12	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231992	200643	0	None	398	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	389	1	1	2	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL599528	200643	0	None	398	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	389	1	1	2	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	202754	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL62	202754	19	None	-2	28	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		14896355	26833	0	None	10	3	Rat	9.6	pKi	=	9.6	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(Br)c2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL13632	26833	0	None	10	3	Rat	9.6	pKi	=	9.6	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(Br)c2)C1	10.1016/s0960-894x(00)00185-2
		1243	3618	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
		944	3618	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
		CHEMBL324017	3618	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
		3038603	101865	8	None	2	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL300647	101865	8	None	2	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		3036864	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1256645	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1814790	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL62	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		3036864	202754	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL62	202754	19	None	-2	28	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		3036864	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		CHEMBL1256645	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		CHEMBL1814790	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		CHEMBL62	202754	19	None	-2	28	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		11269330	201493	0	None	34	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL605127	201493	0	None	34	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3039881	174257	10	None	4	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL45491	174257	10	None	4	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		11558055	73152	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL1204122	73152	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL201170	73152	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		3036864	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1256645	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1814790	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL62	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		11558055	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		CHEMBL1204122	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		CHEMBL201170	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		11558055	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL1204122	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL201170	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
		11558055	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
		CHEMBL1204122	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
		CHEMBL201170	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
		3036864	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL62	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		11558055	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
		CHEMBL1204122	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
		CHEMBL201170	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
		14787973	102667	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1cccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)c1	10.1021/jm00170a025
		CHEMBL304535	102667	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1cccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)c1	10.1021/jm00170a025
		3036864	202754	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1256645	202754	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1814790	202754	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL62	202754	19	None	2	28	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		3036864	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL62	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		11558055	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
		CHEMBL1204122	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
		CHEMBL201170	73152	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
		46231993	200407	0	None	562	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	407	1	1	2	5.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598104	200407	0	None	562	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	407	1	1	2	5.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		CHEMBL62	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		3036864	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL62	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		3036864	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL1256645	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL1814790	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL62	202754	19	None	-2	28	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		3036864	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL62	202754	19	None	-2	28	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		11595240	140188	0	None	-5	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
		CHEMBL380464	140188	0	None	-5	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
		162655154	180773	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4756254	180773	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		44320357	206399	0	None	1202	2	Rat	9.3	pKi	=	9.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87734	206399	0	None	1202	2	Rat	9.3	pKi	=	9.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		11235174	200381	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL597909	200381	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		11374299	200608	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	448	5	1	4	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL599282	200608	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	448	5	1	4	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		46231588	201261	0	None	12022	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	408	4	1	4	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL603901	201261	0	None	12022	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	408	4	1	4	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		3036864	202754	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		CHEMBL1256645	202754	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		CHEMBL1814790	202754	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		CHEMBL62	202754	19	None	-2	28	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		44439943	93366	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL245570	93366	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
		11465618	102398	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	102398	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	102398	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		44439943	93366	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL245570	93366	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2008.04.081
		86346162	132440	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	433	3	1	4	4.2	Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697581	132440	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	433	3	1	4	4.2	Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10088113	162277	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1744079	162277	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL416401	162277	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		11488247	200639	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL599487	200639	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		46232135	200324	0	None	85	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	428	1	2	2	6.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc5[nH]ccc5c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL597503	200324	0	None	85	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	428	1	2	2	6.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc5[nH]ccc5c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231994	200408	0	None	5	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	414	1	1	3	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598105	200408	0	None	5	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	414	1	1	3	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231784	201338	0	None	2	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604314	201338	0	None	2	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231995	201534	0	None	7	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	434	2	1	4	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL605339	201534	0	None	7	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	434	2	1	4	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		44268809	98265	0	None	46	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		CHEMBL274577	98265	0	None	46	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		24873463	148043	0	None	3467	2	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	557	10	0	5	6.0	O=C(CCCN1CCN2CC3C(CC2C1)c1ccccc1N3CCCC(=O)c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		CHEMBL393466	148043	0	None	3467	2	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	557	10	0	5	6.0	O=C(CCCN1CCN2CC3C(CC2C1)c1ccccc1N3CCCC(=O)c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		46231645	200351	0	None	776	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	518	6	1	3	7.2	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(Cc3ccccc3)c3ccc(F)cc3F)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL597702	200351	0	None	776	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	518	6	1	3	7.2	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(Cc3ccccc3)c3ccc(F)cc3F)cc2)C1	10.1016/j.bmcl.2009.12.100
		46231709	200707	0	None	1548	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL599977	200707	0	None	1548	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		11452916	200829	0	None	7	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL600986	200829	0	None	7	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		44268693	23349	0	None	16	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2Br)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL13325	23349	0	None	16	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2Br)C1	10.1016/s0960-894x(00)00185-2
		3036864	202754	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1256645	202754	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1814790	202754	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL62	202754	19	None	-2	28	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		46232067	200289	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	2	1	3	5.7	CN(C)c1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		CHEMBL597310	200289	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	2	1	3	5.7	CN(C)c1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		46232066	201256	0	None	8	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	1	3	5.7	COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		CHEMBL603872	201256	0	None	8	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	1	3	5.7	COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		46232134	201316	0	None	125	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	2	3	5.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc(CO)cc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604176	201316	0	None	125	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	2	3	5.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc(CO)cc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		CHEMBL62	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		3036864	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		CHEMBL62	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		10516818	25651	0	None	2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135197	25651	0	None	2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		14787971	170072	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccccc1[C@H]1CN(C)CCc2cc(Cl)c(O)cc21	10.1021/jm00170a025
		CHEMBL444321	170072	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccccc1[C@H]1CN(C)CCc2cc(Cl)c(O)cc21	10.1021/jm00170a025
		3036864	202754	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		CHEMBL1256645	202754	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		CHEMBL1814790	202754	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		CHEMBL62	202754	19	None	-2	28	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		242	470	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		34	470	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		60795	470	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		CHEMBL1112	470	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		DB01238	470	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		11681599	75173	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL203637	75173	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1016/j.bmcl.2008.04.081
		44439942	151865	0	None	4	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3	10.1016/j.bmcl.2006.11.093
		CHEMBL396560	151865	0	None	4	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3	10.1016/j.bmcl.2006.11.093
		11681599	75173	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
		CHEMBL203637	75173	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
		10802788	168238	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL433652	168238	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		10802788	168238	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL433652	168238	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		3036864	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1256645	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1814790	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL62	202754	19	None	-2	28	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		46231541	200188	0	None	4	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	370	4	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL596622	200188	0	None	4	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	370	4	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1	10.1016/j.bmcl.2009.12.100
		107930	1529	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		3304	1529	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		CHEMBL298406	1529	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		DB12273	1529	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		149506840	183148	0	None	120	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	371	1	1	3	5.8	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4795230	183148	0	None	120	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	371	1	1	3	5.8	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		46232065	200259	0	None	346	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	425	1	1	2	5.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cc(F)cc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL597100	200259	0	None	346	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	425	1	1	2	5.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cc(F)cc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46216855	200378	0	None	2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL597900	200378	0	None	2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		15111050	13348	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1192259	13348	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL543473	13348	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		130844	13202	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL1191103	13202	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL543398	13202	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
		71451380	81237	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	435	3	5	6	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C(O)=C(/O)C(=O)O	10.1016/j.bmc.2012.08.058
		CHEMBL2158641	81237	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	435	3	5	6	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C(O)=C(/O)C(=O)O	10.1016/j.bmc.2012.08.058
		6852376	91599	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL1467585	91599	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL24077	91599	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL503958	91599	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		167715	2876	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		969	2876	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL225230	2876	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		11393666	192986	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	192986	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	192986	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		46231927	201536	0	None	2	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL605354	201536	0	None	2	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		13805900	44009	0	None	-2	6	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@@H]1Cc2cccc(O)c2C[C@H]1C	10.1021/jm020990u
		CHEMBL15136	44009	0	None	-2	6	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@@H]1Cc2cccc(O)c2C[C@H]1C	10.1021/jm020990u
		162646534	179583	0	None	123	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	362	1	1	4	5.0	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4742056	179583	0	None	123	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	362	1	1	4	5.0	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		1242	3613	27	None	-5	18	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		935	3613	27	None	-5	18	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		CHEMBL286080	3613	27	None	-5	18	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		133538	3619	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
		8443	3619	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
		CHEMBL574558	3619	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
		107930	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		3304	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		CHEMBL298406	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		DB12273	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		5018	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		943	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		946	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		CHEMBL13668	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		107930	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		3304	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		CHEMBL298406	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		DB12273	1529	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		15111051	13370	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1192465	13370	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL543704	13370	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		13697621	13741	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL1195188	13741	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL554009	13741	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		1153	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		12668023	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		30026874	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		30026875	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		3341	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		6603851	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		933	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		939	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		985	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		CHEMBL1160786	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		CHEMBL1161520	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		CHEMBL588	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		DB00800	1628	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		3036864	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1256645	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1814790	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL62	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		5018	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		943	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		946	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		CHEMBL13668	3549	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		134139606	146348	0	None	288	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	419	3	2	5	3.9	CCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3921278	146348	0	None	288	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	419	3	2	5	3.9	CCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		3036864	202754	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1256645	202754	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1814790	202754	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL62	202754	19	None	-5	28	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		10638646	26215	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135735	26215	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		11486421	201194	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	400	2	2	4	4.5	CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL603485	201194	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	400	2	2	4	4.5	CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		3036864	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL1256645	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL1814790	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL62	202754	19	None	-2	28	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		142405815	181164	0	None	-10	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	365	2	1	3	5.7	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4760903	181164	0	None	-10	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	365	2	1	3	5.7	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		11223303	200830	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL600987	200830	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		14787975	102232	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1	10.1021/jm00170a025
		CHEMBL303012	102232	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1	10.1021/jm00170a025
		162646218	179476	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4740880	179476	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		122324	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
		6077	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
		CHEMBL86931	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
		122324	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		6077	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		CHEMBL86931	205	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		44415569	165934	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL425069	165934	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		44415569	165934	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL425069	165934	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		46231849	201418	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	356	1	2	4	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604732	201418	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	356	1	2	4	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	202754	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		CHEMBL1256645	202754	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		CHEMBL1814790	202754	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		CHEMBL62	202754	19	None	-2	28	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		129244	118671	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL2114388	118671	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL34170	118671	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		10638646	26215	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135735	26215	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		37461	17134	14	None	-2	8	Rat	8.7	pKi	=	8.7	Binding	Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm9911478
		CHEMBL1255588	17134	14	None	-2	8	Rat	8.7	pKi	=	8.7	Binding	Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm9911478
		46231925	201378	0	None	5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		CHEMBL604525	201378	0	None	5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		73671785	129421	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	3	2	6	2.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3671278	129421	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	3	2	6	2.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		4350931	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL441618	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		10656804	116559	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL336366	116559	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		107930	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		3304	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		CHEMBL298406	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		DB12273	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		107930	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		3304	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		CHEMBL298406	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		DB12273	1529	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		4350931	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
		CHEMBL441618	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
		4350931	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		CHEMBL441618	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		4350931	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL441618	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		4350931	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1039/C5MD00258C
		CHEMBL441618	169313	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1039/C5MD00258C
		12765746	102280	4	None	-8	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL303313	102280	4	None	-8	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		12765746	102280	4	None	-8	9	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL303313	102280	4	None	-8	9	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		9797664	166237	1	None	-4	3	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	331	1	0	4	3.8	CN1CCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL426763	166237	1	None	-4	3	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	331	1	0	4	3.8	CN1CCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		107930	1529	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		3304	1529	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		CHEMBL298406	1529	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		DB12273	1529	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		133538	3619	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
		8443	3619	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
		CHEMBL574558	3619	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
		12765746	102280	4	None	-8	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL303313	102280	4	None	-8	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		4106	2502	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		5358812	2502	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		89	2502	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		CHEMBL93240	2502	22	None	-5	34	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		44348383	16303	0	None	-10	2	Rat	8.7	pKi	=	8.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1021/jm9706832
		CHEMBL122536	16303	0	None	-10	2	Rat	8.7	pKi	=	8.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1021/jm9706832
		135398745	2914	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		47	2914	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		CHEMBL715	2914	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		DB00334	2914	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		15937726	165149	0	None	177	2	Rat	8.0	pKi	=	8	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	293	1	1	2	4.2	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL422796	165149	0	None	177	2	Rat	8.0	pKi	=	8	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	293	1	1	2	4.2	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		44579030	189681	0	None	10	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	377	7	0	3	5.7	CCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL515342	189681	0	None	10	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	377	7	0	3	5.7	CCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415558	80162	0	None	93	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4n3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213443	80162	0	None	93	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4n3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415657	168741	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	4	1	7	4.9	CCOc1csc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		CHEMBL437112	168741	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	4	1	7	4.9	CCOc1csc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		117773683	132442	0	None	-	1	Human	8.0	pKi	=	8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	403	5	1	6	3.5	Cc1cc(Oc2nccc(C)c2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697583	132442	0	None	-	1	Human	8.0	pKi	=	8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	403	5	1	6	3.5	Cc1cc(Oc2nccc(C)c2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		56594534	70600	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
		CHEMBL1949728	70600	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
		90140327	129412	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]c(C)c23)cc1	nan
		CHEMBL3671269	129412	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]c(C)c23)cc1	nan
		74223724	129417	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671274	129417	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		74223826	129437	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671293	129437	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		11637457	73087	1	None	1	5	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
		CHEMBL201093	73087	1	None	1	5	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
		86764102	132478	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1ccnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)cc2)c1Cl	nan
		CHEMBL3697619	132478	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1ccnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)cc2)c1Cl	nan
		135398745	2914	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	2914	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	2914	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	2914	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		11271099	204657	0	None	-501	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	458	9	2	5	4.3	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(N)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL73665	204657	0	None	-501	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	458	9	2	5	4.3	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(N)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		15937722	115224	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	294	1	1	3	3.1	CN1CCc2cc(Cl)c(O)cc2C(N2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL334650	115224	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	294	1	1	3	3.1	CN1CCc2cc(Cl)c(O)cc2C(N2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		49782398	17452	0	None	-138	5	Pig	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	471	6	1	3	5.7	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL1257688	17452	0	None	-138	5	Pig	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	471	6	1	3	5.7	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		6603820	95774	19	None	1	13	Rat	7.0	pKi	=	7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL25856	95774	19	None	1	13	Rat	7.0	pKi	=	7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
		15711850	13239	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1191350	13239	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL542436	13239	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		242	470	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	470	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	470	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	470	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	470	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		135398737	958	93	None	-44	89	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	958	93	None	-44	89	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	958	93	None	-44	89	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	958	93	None	-44	89	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	958	93	None	-44	89	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		2337	3256	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		50	3256	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		5002	3256	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		CHEMBL716	3256	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		DB01224	3256	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		2389	3331	118	None	-489	67	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	3331	118	None	-489	67	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	3331	118	None	-489	67	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	3331	118	None	-489	67	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	3331	118	None	-489	67	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		17449900	139542	13	None	-3548	6	Pig	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL379602	139542	13	None	-3548	6	Pig	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		137633863	156625	0	None	-436	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4069145	156625	0	None	-436	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		44372154	54225	0	None	-11	4	Bovine	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	434	4	0	4	5.4	Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL160749	54225	0	None	-11	4	Bovine	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	434	4	0	4	5.4	Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		9864676	127808	0	None	-58	5	Bovine	6.0	pKi	=	6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL366388	127808	0	None	-58	5	Bovine	6.0	pKi	=	6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		15115530	12918	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
		CHEMBL1189085	12918	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
		CHEMBL538023	12918	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
		44339879	172282	0	None	-186	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL447476	172282	0	None	-186	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		10357869	4884	0	None	-158	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		CHEMBL104453	4884	0	None	-158	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		44412458	139294	3	None	-3090	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	316	4	0	4	3.6	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1	10.1016/j.bmcl.2006.02.075
		CHEMBL379177	139294	3	None	-3090	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	316	4	0	4	3.6	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1	10.1016/j.bmcl.2006.02.075
		45112568	198806	0	None	-229	3	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		CHEMBL583422	198806	0	None	-229	3	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		145980271	166492	0	None	-19	16	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4278465	166492	0	None	-19	16	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		145986752	167276	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		CHEMBL4293307	167276	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		10633305	35994	1	None	-28	2	Bovine	4.0	pKi	=	4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2ccc(C)cc2C)C1	10.1021/jm9708700
		CHEMBL144302	35994	1	None	-28	2	Bovine	4.0	pKi	=	4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2ccc(C)cc2C)C1	10.1021/jm9708700
		44329093	207712	0	None	-309	3	Bovine	4.0	pKi	=	4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@@H]1CCn2ccc(CO)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL95618	207712	0	None	-309	3	Bovine	4.0	pKi	=	4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@@H]1CCn2ccc(CO)c2C1	10.1016/s0960-894x(01)00564-9
		44304814	202872	0	None	-16	4	Bovine	4.0	pKi	=	4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	505	8	1	5	5.9	COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12	10.1016/s0960-894x(00)00405-4
		CHEMBL62601	202872	0	None	-16	4	Bovine	4.0	pKi	=	4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	505	8	1	5	5.9	COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12	10.1016/s0960-894x(00)00405-4
		71109993	143247	0	None	-	1	Human	6.0	pKi	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		CHEMBL3896617	143247	0	None	-	1	Human	6.0	pKi	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		228	445	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		33	445	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		6005	445	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		CHEMBL53	445	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		DB00714	445	28	None	-4	24	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		228	445	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		33	445	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		6005	445	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		CHEMBL53	445	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		DB00714	445	28	None	-30	24	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		74223776	129432	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1C#N	nan
		CHEMBL3671289	129432	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1C#N	nan
		28417	40039	49	None	-1	12	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	40039	49	None	-1	12	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		15711865	13175	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL1190906	13175	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL541838	13175	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		3246545	202474	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL1573438	202474	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL611207	202474	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		44415394	141833	0	None	15	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	471	3	1	5	4.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)/C=C/c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL386424	141833	0	None	15	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	471	3	1	5	4.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)/C=C/c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		13864380	206432	1	None	4	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87958	206432	1	None	4	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
		13864381	208344	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
		CHEMBL542683	208344	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
		CHEMBL99361	208344	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
		10637496	112884	0	None	-58	3	Rat	6.0	pKi	=	6.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	2	0	2	4.0	CCc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL331005	112884	0	None	-58	3	Rat	6.0	pKi	=	6.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	2	0	2	4.0	CCc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		44405995	72996	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		CHEMBL200802	72996	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		56593482	3941	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		7650	3941	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL2165119	3941	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		156018236	177912	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	377	4	1	3	4.9	C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4645139	177912	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	377	4	1	3	4.9	C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1	10.1016/j.bmcl.2020.127305
		154706030	176545	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4580817	176545	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4597188	176545	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		76325156	106390	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3115585	106390	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3139393	106390	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		12050197	100874	0	None	-79	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	457	6	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL293645	100874	0	None	-79	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	457	6	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		10570422	164905	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	6	2	3	4.0	CNCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL422267	164905	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	6	2	3	4.0	CNCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		15627832	98534	0	None	-6	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	345	0	2	3	3.6	CN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL276326	98534	0	None	-6	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	345	0	2	3	3.6	CN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		13646434	124654	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL1743799	124654	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL36416	124654	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		70692652	76064	0	None	8	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057441	76064	0	None	8	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		72708059	92196	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425369	92196	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		161665	172585	35	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		CHEMBL448891	172585	35	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		1353	1911	93	None	-38	83	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		3559	1911	93	None	-38	83	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		86	1911	93	None	-38	83	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		CHEMBL54	1911	93	None	-38	83	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		DB00502	1911	93	None	-38	83	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		72708059	92196	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425369	92196	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		45112462	196966	0	None	-831	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		CHEMBL566533	196966	0	None	-831	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		154706123	176288	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4593394	176288	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595145	176288	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		11724078	41707	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cccnc3Oc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL149240	41707	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cccnc3Oc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		154706513	176586	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4440698	176586	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4597532	176586	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		3117	207841	103	None	-2	16	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	207841	103	None	-2	16	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		44448066	94875	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL253948	94875	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		154704141	176679	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4561808	176679	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4598299	176679	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		117774721	132445	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	5	1	6	2.8	Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697586	132445	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	5	1	6	2.8	Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O	nan
		112500032	132470	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697610	132470	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)cnc(=O)n1C	nan
		10333842	98431	1	None	-50	8	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		CHEMBL27559	98431	1	None	-50	8	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		76325156	106390	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3115585	106390	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3139393	106390	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		9951964	206358	0	None	-22	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87458	206358	0	None	-22	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm00042a009
		44415644	141821	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	583	4	1	5	7.3	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4N(NC(=O)c4ccccc4Cl)c4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL386336	141821	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	583	4	1	5	7.3	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4N(NC(=O)c4ccccc4Cl)c4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		10490043	113721	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960189i
		CHEMBL332332	113721	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960189i
		44386623	61055	0	None	-1	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	376	3	0	4	4.2	COc1c(Cl)c2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		CHEMBL176356	61055	0	None	-1	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	376	3	0	4	4.2	COc1c(Cl)c2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		1212	1662	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	1662	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	1662	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	1662	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	1662	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		44415633	80007	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	7	5.1	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL212807	80007	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	7	5.1	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		44415578	141503	0	None	57	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL384500	141503	0	None	57	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		134151737	152974	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	5	2	5	3.9	CCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3975220	152974	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	5	2	5	3.9	CCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		127031424	138869	0	None	5	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	6	1	5	4.2	CCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3781840	138869	0	None	5	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	6	1	5	4.2	CCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		75201901	166425	19	None	-1	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4277264	166425	19	None	-1	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		44370173	48485	1	None	-18	2	Bovine	7.0	pKi	=	7.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	331	6	2	4	4.0	CCCN(CCc1cccs1)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		CHEMBL155613	48485	1	None	-18	2	Bovine	7.0	pKi	=	7.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	331	6	2	4	4.0	CCCN(CCc1cccs1)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		75201901	166425	19	None	-1	24	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	166425	19	None	-1	24	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		122189393	123248	0	None	-20	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	455	6	0	7	4.0	Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		CHEMBL3613879	123248	0	None	-20	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	455	6	0	7	4.0	Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		122189394	123249	0	None	-354	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	7	0	7	4.4	Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		CHEMBL3613880	123249	0	None	-354	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	7	0	7	4.4	Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		21302486	109800	0	None	-117	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	379	5	1	4	3.9	O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1	10.1021/jm401958n
		CHEMBL3233143	109800	0	None	-117	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	379	5	1	4	3.9	O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1	10.1021/jm401958n
		10092819	16773	0	None	-1412	12	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
		CHEMBL124444	16773	0	None	-1412	12	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
		11133602	30775	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL139600	30775	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		44276404	99078	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL28054	99078	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		44276557	99316	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL282136	99316	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		11761412	116951	0	None	-2290	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
		CHEMBL338606	116951	0	None	-2290	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
		10490043	113721	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm060959i
		CHEMBL332332	113721	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm060959i
		71459761	84080	0	None	-181	7	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207642	84080	0	None	-181	7	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		137635685	156005	0	None	-38	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	417	7	1	7	3.6	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12	10.1021/acs.jmedchem.7b00363
		CHEMBL4061986	156005	0	None	-38	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	417	7	1	7	3.6	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12	10.1021/acs.jmedchem.7b00363
		25072633	159221	0	None	-1584	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4098803	159221	0	None	-1584	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		118709166	113412	0	None	-19	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	25	0	8	12.9	O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318838	113412	0	None	-19	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	25	0	8	12.9	O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		164615845	185190	0	None	-1	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		CHEMBL4857492	185190	0	None	-1	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		10833953	31125	0	None	-1445	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL140006	31125	0	None	-1445	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1	10.1021/jm0009989
		44380697	58093	0	None	-61	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL167414	58093	0	None	-61	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44380685	58735	0	None	-77	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL168566	58735	0	None	-77	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44380815	59010	0	None	-234	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL169193	59010	0	None	-234	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		44264682	97318	0	None	-2754	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1	10.1016/s0960-894x(98)00692-1
		CHEMBL269202	97318	0	None	-2754	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1	10.1016/s0960-894x(98)00692-1
		15508243	5303	22	None	-7	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	366	3	0	2	3.9	Ic1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL106635	5303	22	None	-7	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	366	3	0	2	3.9	Ic1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		25099153	187253	0	None	-257039	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	436	9	2	5	4.7	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL492664	187253	0	None	-257039	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	436	9	2	5	4.7	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		45270021	195164	0	None	-158	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	335	3	0	5	3.0	Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL550392	195164	0	None	-158	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	335	3	0	5	3.0	Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		45272580	196456	0	None	-165	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL563109	196456	0	None	-165	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		102262219	140059	0	None	-22908	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800400	140059	0	None	-22908	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		137655029	158946	0	None	-2691	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	452	8	1	9	2.6	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12	10.1016/j.bmc.2017.08.037
		CHEMBL4095881	158946	0	None	-2691	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	452	8	1	9	2.6	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12	10.1016/j.bmc.2017.08.037
		137657427	159559	0	None	-9772	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	476	7	3	6	3.5	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4102628	159559	0	None	-9772	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	476	7	3	6	3.5	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		10361512	54439	0	None	-4786	5	Bovine	5.0	pKi	=	5.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	365	3	0	5	3.5	Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL160932	54439	0	None	-4786	5	Bovine	5.0	pKi	=	5.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	365	3	0	5	3.5	Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		154706590	176309	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4590839	176309	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595264	176309	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		71110301	92198	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425371	92198	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		44415368	79603	0	None	17	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	465	4	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCC3CCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL211461	79603	0	None	17	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	465	4	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCC3CCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		14198586	201833	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL60706	201833	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1016/j.bmc.2009.05.079
		156013666	177279	0	None	-10	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	3	1	4	3.6	COc1cc2c3c(c1OC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4636318	177279	0	None	-10	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	3	1	4	3.6	COc1cc2c3c(c1OC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		2726	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		154704536	176447	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4467528	176447	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4596340	176447	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		154703875	176448	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4586582	176448	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4596341	176448	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		11335419	67100	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
		CHEMBL187367	67100	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
		74223726	129419	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	10.1021/acs.jmedchem.8b01767
		CHEMBL3671276	129419	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	10.1021/acs.jmedchem.8b01767
		74223726	129419	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		CHEMBL3671276	129419	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		10497993	168474	0	None	2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL43514	168474	0	None	2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
		3038495	708	37	None	-616	19	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
		7625	708	37	None	-616	19	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
		CHEMBL25236	708	37	None	-616	19	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
		136074293	203057	0	None	-3	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1cnc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm00067a009
		CHEMBL63590	203057	0	None	-3	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1cnc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm00067a009
		45481842	198061	0	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	3	1	2	3.8	CCCCC1c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		CHEMBL574112	198061	0	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	3	1	2	3.8	CCCCC1c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		56589561	70601	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO	10.1021/jm200676f
		CHEMBL1949729	70601	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO	10.1021/jm200676f
		135398737	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		38	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		722	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		CHEMBL42	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		DB00363	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		242	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		34	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		60795	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL1112	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB01238	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		242	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		34	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		60795	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL1112	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB01238	470	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		76325154	106406	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3115580	106406	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3139475	106406	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		154703647	176365	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4450429	176365	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4595728	176365	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		135398737	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		38	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		722	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		CHEMBL42	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		DB00363	958	93	None	-83	89	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		156016177	177654	0	None	-114	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		CHEMBL4641502	177654	0	None	-114	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		12049520	101065	5	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	319	4	0	4	3.7	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL294780	101065	5	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	319	4	0	4	3.7	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1	10.1016/s0960-894x(00)00405-4
		44593524	184056	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2008.05.077
		CHEMBL482276	184056	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2008.05.077
		76325154	106406	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3115580	106406	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3139475	106406	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		44448062	94848	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253737	94848	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		117774133	132418	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	5	4.1	Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697559	132418	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	5	4.1	Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		90644065	111661	0	None	-8	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	5	0	4	4.2	Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3286429	111661	0	None	-8	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	5	0	4	4.2	Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		53318565	58601	0	None	-6	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684134	58601	0	None	-6	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		10000788	47993	0	None	-41	3	Rat	5.9	pKi	=	5.9	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	395	6	1	4	3.9	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCN(c3ccccc3OC)CC1)CC2	10.1016/0960-894X(95)00076-6
		CHEMBL155006	47993	0	None	-41	3	Rat	5.9	pKi	=	5.9	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	395	6	1	4	3.9	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCN(c3ccccc3OC)CC1)CC2	10.1016/0960-894X(95)00076-6
		10832461	51264	0	None	-1	2	Rat	4.9	pKi	=	4.9	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)c2c(c1)CCN(C)C2Cc1ccccc1O	10.1021/jm991034o
		CHEMBL158067	51264	0	None	-1	2	Rat	4.9	pKi	=	4.9	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)c2c(c1)CCN(C)C2Cc1ccccc1O	10.1021/jm991034o
		86763998	132474	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697614	132474	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		135398745	2914	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		47	2914	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		CHEMBL715	2914	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		DB00334	2914	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		91899760	129447	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	1	5	4.3	Cc1cc(Oc2nccc3n[nH]cc23)c(F)cc1-c1c(C)ncnc1C	nan
		CHEMBL3671302	129447	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	1	5	4.3	Cc1cc(Oc2nccc3n[nH]cc23)c(F)cc1-c1c(C)ncnc1C	nan
		12304090	87508	36	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL2334886	87508	36	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@H]21	10.1016/j.bmc.2012.12.016
		135398745	2914	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		47	2914	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		CHEMBL715	2914	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		DB00334	2914	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		168289523	191499	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis	ChEMBL	422	5	1	2	6.0	FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1	10.1016/j.bmcl.2022.128615
		CHEMBL5193761	191499	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis	ChEMBL	422	5	1	2	6.0	FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1	10.1016/j.bmcl.2022.128615
		10276451	200285	37	None	-12022	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		CHEMBL2112910	200285	37	None	-12022	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		CHEMBL59725	200285	37	None	-12022	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		10531	1420	21	None	-218	23	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	1420	21	None	-218	23	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	1420	21	None	-218	23	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	1420	21	None	-218	23	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	1420	21	None	-218	23	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		2435	3590	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		60149	3590	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		98	3590	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		CHEMBL12713	3590	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		DB06144	3590	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		25141414	182481	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	5	0	3	4.9	CCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL478671	182481	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	5	0	3	4.9	CCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415721	80042	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	605	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212936	80042	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	605	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415703	79821	0	None	537	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)c(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212077	79821	0	None	537	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)c(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415688	80171	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213477	80171	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		134143833	150515	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	355	4	2	5	3.6	CCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3954556	150515	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	355	4	2	5	3.6	CCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		127031403	138734	0	None	4	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	381	5	1	5	3.9	COc1cc2c(cc1O)C1Cc3ccc(OCC4CC4)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780184	138734	0	None	4	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	381	5	1	5	3.9	COc1cc2c(cc1O)C1Cc3ccc(OCC4CC4)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		10733562	147014	0	None	25	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL39266	147014	0	None	25	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
		9819042	13157	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
		CHEMBL1190761	13157	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
		CHEMBL541559	13157	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
		1241	100179	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL288090	100179	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL552611	100179	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
		117773867	132454	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	1	4	4.9	Cc1cc(Oc2nccc(C)c2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697594	132454	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	1	4	4.9	Cc1cc(Oc2nccc(C)c2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		6917970	3691	61	None	-1	34	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
		8370	3691	61	None	-1	34	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
		CHEMBL487387	3691	61	None	-1	34	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
		127031422	138718	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	4	1	5	3.5	CCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3779928	138718	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	4	1	5	3.5	CCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		14198584	198269	0	None	12	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00118a012
		CHEMBL57579	198269	0	None	12	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00118a012
		117773559	132483	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	416	3	2	5	3.7	Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697624	132483	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	416	3	2	5	3.7	Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)[nH]c1=O	nan
		10005244	111351	0	None	7	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	476	5	1	3	5.9	CN(C)c1ccc(/C=C/CN2CCc3cc(Br)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		CHEMBL326927	111351	0	None	7	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	476	5	1	3	5.9	CN(C)c1ccc(/C=C/CN2CCc3cc(Br)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		44323876	206582	0	None	2	4	Rat	6.9	pKi	=	6.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL88870	206582	0	None	2	4	Rat	6.9	pKi	=	6.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		1353	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		3559	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		86	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		CHEMBL54	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		DB00502	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		117773696	132426	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	6	2.7	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1F	nan
		CHEMBL3697567	132426	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	6	2.7	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1F	nan
		86764101	132477	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		CHEMBL3697618	132477	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		276	3513	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		5312149	3513	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		CHEMBL431298	3513	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		11575479	94743	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		CHEMBL253096	94743	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		1353	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		3559	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		86	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		CHEMBL54	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		DB00502	1911	93	None	-38	83	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		118709178	113348	0	None	-69	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1154	32	0	17	9.5	O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3317465	113348	0	None	-69	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1154	32	0	17	9.5	O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		122189392	123247	0	None	-54	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	441	5	0	7	3.6	Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		CHEMBL3613878	123247	0	None	-54	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	441	5	0	7	3.6	Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		71458071	79500	0	None	-102	6	Bovine	5.9	pKi	=	5.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(02)00316-5
		CHEMBL2113718	79500	0	None	-102	6	Bovine	5.9	pKi	=	5.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(02)00316-5
		6603820	95774	19	None	-4	13	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9800292
		CHEMBL25856	95774	19	None	-4	13	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9800292
		6603954	202605	2	None	-81	3	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm9800292
		CHEMBL612083	202605	2	None	-81	3	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm9800292
		11068912	30864	0	None	-39	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL139722	30864	0	None	-39	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		11057969	33271	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL141845	33271	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		44360992	119404	0	None	-134	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1	10.1021/jm025558r
		CHEMBL344677	119404	0	None	-134	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1	10.1021/jm025558r
		11036640	121147	0	None	-29	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL357684	121147	0	None	-29	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		44264642	204803	0	None	-398	4	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		CHEMBL7506	204803	0	None	-398	4	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		56833463	68336	0	None	-602	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	578	17	1	9	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		CHEMBL1916552	68336	0	None	-602	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	578	17	1	9	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		137643951	158259	0	None	-831	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4088639	158259	0	None	-831	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		56837635	69308	0	None	-3981	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1129	44	2	17	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928132	69308	0	None	-3981	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1129	44	2	17	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		118709164	113410	0	None	-199	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	902	22	0	8	11.7	O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318836	113410	0	None	-199	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	902	22	0	8	11.7	O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		44371932	119648	0	None	-467	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	354	4	0	5	3.1	O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL346805	119648	0	None	-467	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	354	4	0	5	3.1	O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		10404144	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(02)00316-5
		CHEMBL7927	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(02)00316-5
		10404144	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm015522j
		CHEMBL7927	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm015522j
		44380785	120803	0	None	-363	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL355566	120803	0	None	-363	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		10404144	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7927	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		10404144	205302	23	None	-2187	10	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm060166w
		CHEMBL7927	205302	23	None	-2187	10	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm060166w
		44340097	9440	0	None	-4365	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL111749	9440	0	None	-4365	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		45270861	195080	0	None	-33	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	353	3	0	5	3.1	Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL549638	195080	0	None	-33	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	353	3	0	5	3.1	Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		681	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		940	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		947	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		CHEMBL59	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		DB00988	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		137651322	157475	0	None	-13489	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	465	8	2	9	2.2	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12	10.1016/j.bmc.2017.08.037
		CHEMBL4079375	157475	0	None	-13489	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	465	8	2	9	2.2	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12	10.1016/j.bmc.2017.08.037
		137640189	156953	0	None	-15848	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	466	7	3	7	2.6	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4072780	156953	0	None	-15848	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	466	7	3	7	2.6	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		681	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		940	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		947	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		CHEMBL59	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		DB00988	1465	72	None	-154	39	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		107995	97126	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
		29982233	97126	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
		CHEMBL267723	97126	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
		44329282	169115	0	None	-19	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL440143	169115	0	None	-19	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		10404144	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL7927	205302	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		10247720	13054	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL1190042	13054	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL540039	13054	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
		10474964	130471	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	130471	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	130471	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		10404144	205302	23	None	-4466	10	Human	4.9	pKi	=	4.9	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/acs.jmedchem.7b00151
		CHEMBL7927	205302	23	None	-4466	10	Human	4.9	pKi	=	4.9	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/acs.jmedchem.7b00151
		45481841	198060	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(Cl)c(O)cc21	10.1016/j.bmc.2009.05.079
		CHEMBL574111	198060	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(Cl)c(O)cc21	10.1016/j.bmc.2009.05.079
		90142280	167296	1	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		CHEMBL4293757	167296	1	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		15711855	13412	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192799	13412	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL544099	13412	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		13838742	99401	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		CHEMBL282710	99401	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		117773223	132451	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	350	4	2	5	2.6	Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697591	132451	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	350	4	2	5	2.6	Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		25129807	103294	0	None	-63	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		CHEMBL3084502	103294	0	None	-63	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		91899762	129452	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cn[nH]c(=O)c1C	nan
		CHEMBL3671307	129452	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cn[nH]c(=O)c1C	nan
		491	192	9	None	-77624	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		9891167	192	9	None	-77624	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		CHEMBL13856	192	9	None	-77624	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		2284	3182	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	3182	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	3182	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	3182	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	3182	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		44415582	138990	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	444	1	0	4	5.3	Cc1ccccc1C(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL378543	138990	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	444	1	0	4	5.3	Cc1ccccc1C(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		681	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		940	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		947	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		CHEMBL59	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		DB00988	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		44241581	14021	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197218	14021	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL562935	14021	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		3032727	13476	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL1193245	13476	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL544618	13476	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		74223828	129443	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	4	1	6	3.8	COc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		CHEMBL3671299	129443	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	4	1	6	3.8	COc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		10519436	11226	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL1178784	11226	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL41238	11226	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		10664137	162755	0	None	10	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL417164	162755	0	None	10	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		15711851	13540	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL1193797	13540	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL545264	13540	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		9838572	63453	0	None	-23	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	279	1	0	3	2.6	CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1	10.1021/jm049629t
		CHEMBL179775	63453	0	None	-23	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	279	1	0	3	2.6	CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1	10.1021/jm049629t
		10072800	96662	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL263790	96662	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL554199	96662	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		12050193	203196	0	None	-2	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	443	5	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL64325	203196	0	None	-2	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	443	5	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		12050199	100812	0	None	-32	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	7	1	5	4.9	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL293225	100812	0	None	-32	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	7	1	5	4.9	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		10068602	100203	1	None	-4677	3	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	384	6	0	4	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL28831	100203	1	None	-4677	3	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	384	6	0	4	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		71528209	86972	0	None	-1949	7	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		CHEMBL2323582	86972	0	None	-1949	7	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		57398351	70158	0	None	-13	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	347	6	0	2	5.1	Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940406	70158	0	None	-13	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	347	6	0	2	5.1	Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		10801923	177764	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	269	2	2	3	2.7	COc1cc2c(cc1O)C(c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4642805	177764	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	269	2	2	3	2.7	COc1cc2c(cc1O)C(c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		44555445	199929	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)Cc1ccccc1C2	10.1016/j.bmc.2009.08.028
		CHEMBL594789	199929	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)Cc1ccccc1C2	10.1016/j.bmc.2009.08.028
		127027739	137984	0	None	-11220	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	382	7	1	6	1.7	O=C(NCCCN1CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3764390	137984	0	None	-11220	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	382	7	1	6	1.7	O=C(NCCCN1CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		60167166	75295	0	None	-41	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL2037430	75295	0	None	-41	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		441383	20333	57	None	-12	16	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	20333	57	None	-12	16	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		154705038	176646	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4584481	176646	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4598001	176646	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		145967904	165097	0	None	-11	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	247	6	1	2	3.8	CCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4227192	165097	0	None	-11	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	247	6	1	2	3.8	CCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		145988180	165231	0	None	-10	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4229178	165231	0	None	-10	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		72699716	115189	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344459	115189	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		44326751	108615	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL320572	108615	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL539544	108615	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
		24949690	181606	0	None	-1819	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		CHEMBL477200	181606	0	None	-1819	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		154705015	176514	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4454380	176514	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4596929	176514	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4576555	214017	5	None	-1	19	Human	5.9	pKi	=	5.9	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		9930475	206290	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL87026	206290	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm981094e
		9930475	206290	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87026	206290	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		91899761	129449	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	317	3	1	5	3.8	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		CHEMBL3671304	129449	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	317	3	1	5	3.8	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		15937725	117105	0	None	158	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	279	1	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C(C2CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL339342	117105	0	None	158	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	279	1	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C(C2CCCC2)C1	10.1016/S0960-894X(00)80155-9
		44415615	139535	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL379560	139535	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		44415507	80287	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		CHEMBL214016	80287	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		10710466	156415	0	None	11	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL40667	156415	0	None	11	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		74223725	129418	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C	nan
		CHEMBL3671275	129418	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C	nan
		117774412	132455	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.5	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)F	nan
		CHEMBL3697595	132455	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.5	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)F	nan
		44281202	100405	3	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	379	1	1	2	3.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL290118	100405	3	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	379	1	1	2	3.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		44320061	106032	0	None	75	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL313304	106032	0	None	75	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		17755866	142884	1	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
		CHEMBL389356	142884	1	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
		681	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		940	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		947	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		CHEMBL59	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		DB00988	1465	72	None	-154	39	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		15115517	9713	0	None	-426	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL113196	9713	0	None	-426	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		6852376	91599	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		CHEMBL1467585	91599	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		CHEMBL24077	91599	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		CHEMBL503958	91599	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		2865	4143	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		59	4143	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		60854	4143	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL708	4143	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB00246	4143	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		146025727	171685	0	None	-4	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	171685	0	None	-4	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44415686	79979	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	7	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212700	79979	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	7	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		24800527	155720	0	None	-4	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	1	3	3.5	CCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL405369	155720	0	None	-4	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	1	3	3.5	CCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		57403525	70154	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940402	70154	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		118709159	113405	0	None	-21	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	832	17	0	8	9.7	O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318831	113405	0	None	-21	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	832	17	0	8	9.7	O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		2337	3256	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		50	3256	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		5002	3256	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL716	3256	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB01224	3256	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		44403219	71904	0	None	-1174	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1	10.1016/j.bmcl.2005.07.037
		CHEMBL197162	71904	0	None	-1174	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1	10.1016/j.bmcl.2005.07.037
		10448562	115120	1	None	12	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL334350	115120	1	None	12	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		16105549	67785	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
		CHEMBL1908879	67785	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
		CHEMBL221640	67785	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
		71459759	84071	0	None	-81	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	432	4	0	3	5.5	COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207633	84071	0	None	-81	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	432	4	0	3	5.5	COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		44567686	192067	0	None	-1	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	265	1	0	2	3.4	COc1cc2c3c(c1)-c1ccccc1C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.06.016
		CHEMBL520262	192067	0	None	-1	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	265	1	0	2	3.4	COc1cc2c3c(c1)-c1ccccc1C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.06.016
		53327663	66479	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852239	66479	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL3215641	66479	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		137643309	158415	0	None	-1174	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4090208	158415	0	None	-1174	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		122181326	121867	0	None	-426	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	413	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.12.012
		CHEMBL3590077	121867	0	None	-426	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	413	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.12.012
		122181329	121870	0	None	-4168	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	394	10	1	2	4.6	CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3590080	121870	0	None	-4168	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	394	10	1	2	4.6	CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		57402787	69195	0	None	-371	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	977	28	2	17	4.4	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1926700	69195	0	None	-371	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	977	28	2	17	4.4	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		9995904	31219	4	None	-14454	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm060166w
		CHEMBL140099	31219	4	None	-14454	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm060166w
		11626748	140159	0	None	-14	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	459	4	0	7	3.1	CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1	10.1021/jm060166w
		CHEMBL380287	140159	0	None	-14	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	459	4	0	7	3.1	CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1	10.1021/jm060166w
		44340186	9660	0	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		CHEMBL112831	9660	0	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		9995904	31219	4	None	-14454	5	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL140099	31219	4	None	-14454	5	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm0009989
		25139180	184341	0	None	-42	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	490	10	1	2	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		CHEMBL484357	184341	0	None	-42	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	490	10	1	2	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		25099152	187286	0	None	-20417	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	466	9	2	5	5.1	CCCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c2ccccc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL492883	187286	0	None	-20417	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	466	9	2	5	5.1	CCCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c2ccccc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		25130817	187512	0	None	-5888	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	518	9	2	5	6.5	CC(C)CCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL494309	187512	0	None	-5888	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	518	9	2	5	6.5	CC(C)CCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		73347474	91059	0	None	-12882	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		CHEMBL2397478	91059	0	None	-12882	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		137655556	158539	0	None	-3801	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	2	7	3.3	O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		CHEMBL4091507	158539	0	None	-3801	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	2	7	3.3	O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		71733935	90983	0	None	-30902	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		CHEMBL2396663	90983	0	None	-30902	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		14665503	91234	0	None	-21379	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	382	7	1	4	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL240106	91234	0	None	-21379	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	382	7	1	4	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		44437896	152468	0	None	-1174	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	400	6	1	3	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC	10.1016/j.bmc.2007.07.017
		CHEMBL397103	152468	0	None	-1174	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	400	6	1	3	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC	10.1016/j.bmc.2007.07.017
		44329283	207641	0	None	-30	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@H]1CCn2c(CO)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL95230	207641	0	None	-30	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@H]1CCn2c(CO)ccc2C1	10.1016/s0960-894x(01)00564-9
		53321194	58602	0	None	-56	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684135	58602	0	None	-56	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		154724650	176337	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4543870	176337	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595492	176337	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		154706711	176515	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4439535	176515	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596930	176515	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		10024430	207613	0	None	-41	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL95098	207613	0	None	-41	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		135398737	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		38	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		722	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		CHEMBL42	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		DB00363	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		135398737	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		38	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		722	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		CHEMBL42	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		DB00363	958	93	None	-44	89	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		156011597	177379	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4637938	177379	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		72699717	115190	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	5	1	4	4.9	CCCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344460	115190	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	5	1	4	4.9	CCCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		2600	3779	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	3779	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	3779	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	3779	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	3779	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		57393083	70167	0	None	-21	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	314	6	0	4	2.8	Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940415	70167	0	None	-21	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	314	6	0	4	2.8	Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		45483261	197886	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	380	3	0	6	3.4	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ncncc21	10.1016/j.bmcl.2009.09.041
		CHEMBL572708	197886	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	380	3	0	6	3.4	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ncncc21	10.1016/j.bmcl.2009.09.041
		11795165	9369	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL111352	9369	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL541842	9369	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		45267373	14018	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197201	14018	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL562460	14018	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		44278589	98450	0	None	-11	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@@H]1Cc1ccccc1-3	10.1021/jm00402a024
		CHEMBL27574	98450	0	None	-11	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@@H]1Cc1ccccc1-3	10.1021/jm00402a024
		5311191	112631	7	None	-35	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL330274	112631	7	None	-35	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		15021875	104369	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm00111a046
		CHEMBL310153	104369	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm00111a046
		15021875	104369	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm981094e
		CHEMBL310153	104369	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm981094e
		10645469	110557	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL325253	110557	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL542428	110557	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		9979654	207919	0	None	-14	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL96781	207919	0	None	-14	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		155516042	176293	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4443039	176293	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4595150	176293	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		12442999	87510	6	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2334890	87510	6	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		57391307	70163	0	None	-19	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	348	6	0	3	4.1	Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940411	70163	0	None	-19	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	348	6	0	3	4.1	Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		71722301	102473	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
		CHEMBL3040157	102473	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
		CHEMBL3216146	102473	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
		53324045	57071	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644980	57071	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		44358192	202143	5	None	-676	2	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	345	1	2	2	2.3	CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]21	10.1021/jm9800292
		CHEMBL609151	202143	5	None	-676	2	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	345	1	2	2	2.3	CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]21	10.1021/jm9800292
		10862670	18502	0	None	-281	5	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
		CHEMBL126439	18502	0	None	-281	5	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
		CHEMBL127317	18502	0	None	-281	5	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
		15467373	101854	0	None	-107	4	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(99)00302-9
		CHEMBL300553	101854	0	None	-107	4	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(99)00302-9
		53946795	67733	1	None	-1122	2	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		CHEMBL1907814	67733	1	None	-1122	2	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		136074292	203570	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cnccc3Nc3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL66730	203570	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cnccc3Nc3ccccc32)CC1	10.1021/jm00067a009
		44304652	200322	0	None	-28	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL59749	200322	0	None	-28	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		71062646	149543	0	None	-2238	12	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		CHEMBL3946661	149543	0	None	-2238	12	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		13373172	199783	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	251	0	1	2	3.0	Oc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		CHEMBL593897	199783	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	251	0	1	2	3.0	Oc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		17756212	86368	1	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		CHEMBL231374	86368	1	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		2286	3183	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	3183	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	3183	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	3183	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	3183	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		11080	29085	79	None	-5	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	29085	79	None	-5	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		44210226	116531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		CHEMBL336218	116531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		117773821	132461	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	1	4	4.0	Cc1cc(Oc2ncc(F)cc2C)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697601	132461	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	1	4	4.0	Cc1cc(Oc2ncc(F)cc2C)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10851717	78477	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	78477	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		154725484	176465	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4439544	176465	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4596514	176465	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		9970201	170643	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		CHEMBL445129	170643	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		168295528	193031	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	193031	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	193031	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10249506	8805	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL109673	8805	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL544091	8805	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		10851717	78477	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	78477	1	None	-15	5	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		155770281	177747	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4642592	177747	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		23656544	170111	0	None	-575	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	2	3	2.6	CN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		CHEMBL444368	170111	0	None	-575	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	2	3	2.6	CN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		5352624	67239	44	None	-3	5	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		CHEMBL18797	67239	44	None	-3	5	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		2662	11384	131	None	-3	30	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		CHEMBL118	11384	131	None	-3	30	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		16104	161917	19	None	-1	5	Rat	7.9	pKi	=	7.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00043a008
		CHEMBL415300	161917	19	None	-1	5	Rat	7.9	pKi	=	7.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00043a008
		44415544	80237	0	None	169	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Br)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213775	80237	0	None	169	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Br)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415628	139792	0	None	104	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccs3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL379874	139792	0	None	104	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccs3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		156017431	177777	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		CHEMBL4643069	177777	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		10981731	15269	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL121274	15269	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		11014679	114788	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL333955	114788	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		16351	102730	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL304902	102730	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		9841398	99519	4	None	3	4	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL28338	99519	4	None	3	4	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		44320024	107067	0	None	51	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL315750	107067	0	None	51	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		86767093	129423	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		CHEMBL3671280	129423	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		16351	102730	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL304902	102730	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		11014679	114788	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL333955	114788	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		10981731	15269	0	None	-3	3	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL121274	15269	0	None	-3	3	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		44276412	97665	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL27117	97665	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		44276556	99702	0	None	30	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL284644	99702	0	None	30	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		45482180	197904	0	None	-17	4	Pig	6.9	pKi	=	6.9	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	544	12	1	7	4.6	COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		CHEMBL572867	197904	0	None	-17	4	Pig	6.9	pKi	=	6.9	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	544	12	1	7	4.6	COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		130442480	175270	0	None	-1	24	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	175270	0	None	-1	24	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		53328903	66458	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
		CHEMBL1802237	66458	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
		CHEMBL1852107	66458	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
		52919	14450	48	None	-15	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL1200986	14450	48	None	-15	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		14198590	203386	1	None	-1	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00118a012
		CHEMBL65397	203386	1	None	-1	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00118a012
		10895106	32227	0	None	-27	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL140968	32227	0	None	-27	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		10053476	116746	0	None	-2570	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	559	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1	10.1021/jm025558r
		CHEMBL337531	116746	0	None	-2570	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	559	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1	10.1021/jm025558r
		44454707	97831	0	None	-28	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2007.12.026
		CHEMBL272073	97831	0	None	-28	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2007.12.026
		44393411	66093	0	None	-316	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	587	7	1	4	6.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1	10.1016/j.bmcl.2004.05.052
		CHEMBL183871	66093	0	None	-316	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	587	7	1	4	6.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1	10.1016/j.bmcl.2004.05.052
		71459760	84072	0	None	-74	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	398	5	0	3	5.3	CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		CHEMBL2207634	84072	0	None	-74	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	398	5	0	3	5.3	CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		25072941	156474	0	None	-331	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4067439	156474	0	None	-331	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		137640371	156814	0	None	-933	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4071185	156814	0	None	-933	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		118709165	113411	0	None	-66	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	916	23	0	8	12.1	O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318837	113411	0	None	-66	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	916	23	0	8	12.1	O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		118709167	113413	0	None	-16	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	972	27	0	8	13.6	O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318839	113413	0	None	-16	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	972	27	0	8	13.6	O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		118709170	113417	0	None	-53	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1057	33	0	8	16.0	O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318842	113417	0	None	-53	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1057	33	0	8	16.0	O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		44372296	119487	0	None	-72	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1	10.1016/s0960-894x(01)00814-9
		CHEMBL345357	119487	0	None	-72	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1	10.1016/s0960-894x(01)00814-9
		CHEMBL5074765	214332	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		O=C(O)c1cc(-c2ccc([C@@H]3C[C@@H]4C[C@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
		CHEMBL5079653	214631	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		O=C(O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3NC4=O)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
		CHEMBL5085145	214951	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		N[C@H]1C[C@@H](CO)[C@H](c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)C1	10.1021/acs.jmedchem.1c01964
		CHEMBL5087121	215070	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		CN(C)C(=O)COC(=O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
		44380774	120475	0	None	-851	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL354180	120475	0	None	-851	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		44336571	4831	0	None	-61	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		CHEMBL104201	4831	0	None	-61	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		15508239	6256	0	None	-5	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	336	3	0	2	4.6	C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL108160	6256	0	None	-5	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	336	3	0	2	4.6	C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		15508240	110527	0	None	-15	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	264	3	0	2	3.3	C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL325104	110527	0	None	-15	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	264	3	0	2	3.3	C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		10496727	13262	0	None	-24	3	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	331	2	0	3	4.7	COc1c(-c2ccco2)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL119150	13262	0	None	-24	3	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	331	2	0	3	4.7	COc1c(-c2ccco2)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		90644066	112040	0	None	-17	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	5	0	3	4.8	Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289653	112040	0	None	-17	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	5	0	3	4.8	Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		53328721	66435	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1851968	66435	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL3216523	66435	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		279	1661	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
		49381	1661	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
		CHEMBL63756	1661	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
		279	1661	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
		49381	1661	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
		CHEMBL63756	1661	26	None	-29	18	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
		44210226	116531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		CHEMBL336218	116531	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		14198588	171507	2	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		CHEMBL446396	171507	2	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		14198590	203386	1	None	1	4	Human	6.9	pKi	=	6.9	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00129a006
		CHEMBL65397	203386	1	None	1	4	Human	6.9	pKi	=	6.9	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00129a006
		44582676	189779	0	None	-10	17	Human	5.9	pKi	=	5.9	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	189779	0	None	-10	17	Human	5.9	pKi	=	5.9	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		13922235	99540	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		CHEMBL283489	99540	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		13922235	99540	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL283489	99540	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		13922235	99540	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		CHEMBL283489	99540	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		10433336	78518	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	439	8	1	4	4.3	BC#N.CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL2111925	78518	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	439	8	1	4	4.3	BC#N.CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		135	2532	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		1796	2532	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		4184	2532	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		CHEMBL6437	2532	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		DB06148	2532	43	None	-46	58	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		5320227	95837	59	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	354	6	1	5	4.6	CC(C)=CC(O)C/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12	10.1016/j.bmc.2007.12.021
		CHEMBL258939	95837	59	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	354	6	1	5	4.6	CC(C)=CC(O)C/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12	10.1016/j.bmc.2007.12.021
		154706461	176348	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4470439	176348	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595600	176348	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		44537925	198744	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL582945	198744	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		156010755	177141	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	351	2	1	3	4.3	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		CHEMBL4633950	177141	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	351	2	1	3	4.3	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		11112574	18507	0	None	-131	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	419	8	1	6	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3n2)CC1	10.1021/jm0211220
		CHEMBL127344	18507	0	None	-131	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	419	8	1	6	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3n2)CC1	10.1021/jm0211220
		10732337	112991	0	None	-13	3	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	291	2	0	2	4.1	C=Cc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL331100	112991	0	None	-13	3	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	291	2	0	2	4.1	C=Cc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		70684207	76070	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057452	76070	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70684207	76070	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057452	76070	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		31101	729	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	729	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	729	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	729	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	729	40	None	-436	36	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		44582490	190137	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	4.2	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL517349	190137	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	4.2	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		1353	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		3559	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		86	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		CHEMBL54	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		DB00502	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		196129	67798	17	None	-1819	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	67798	17	None	-1819	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		154704368	176471	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4569006	176471	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596571	176471	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		11408148	128720	0	None	-371	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		CHEMBL366904	128720	0	None	-371	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		154725234	176292	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4585289	176292	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4595149	176292	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		73453	29616	24	None	-208	17	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	29616	24	None	-208	17	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		33630	178957	99	None	-5	28	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL47050	178957	99	None	-5	28	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		2389	3331	118	None	-346	67	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		5073	3331	118	None	-346	67	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		96	3331	118	None	-346	67	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		CHEMBL85	3331	118	None	-346	67	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		DB00734	3331	118	None	-346	67	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		156014482	177212	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	303	2	2	3	3.3	COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4635423	177212	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	303	2	2	3	3.3	COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		2389	3331	118	None	-489	67	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		5073	3331	118	None	-489	67	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		96	3331	118	None	-489	67	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		CHEMBL85	3331	118	None	-489	67	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		DB00734	3331	118	None	-489	67	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		21589014	144072	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3903297	144072	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		10044334	207121	18	None	-64	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL92145	207121	18	None	-64	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		44415568	140143	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C(F)(F)F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL380236	140143	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C(F)(F)F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		155529453	171438	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranesDisplacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranes	ChEMBL	385	4	2	3	4.3	COc1ccc2[nH]cc(C3=CCN(Cc4cc(=O)[nH]c5ccccc45)CC3)c2c1	10.1016/j.ejmech.2019.07.050
		CHEMBL4463034	171438	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranesDisplacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranes	ChEMBL	385	4	2	3	4.3	COc1ccc2[nH]cc(C3=CCN(Cc4cc(=O)[nH]c5ccccc45)CC3)c2c1	10.1016/j.ejmech.2019.07.050
		11406143	66132	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	372	7	0	3	4.5	c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm049720x
		CHEMBL184073	66132	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	372	7	0	3	4.5	c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm049720x
		10895039	18520	0	None	-3019	8	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL127400	18520	0	None	-3019	8	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL129022	18520	0	None	-3019	8	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		44593524	184056	0	None	-12	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.11.025
		CHEMBL482276	184056	0	None	-12	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.11.025
		10740666	26123	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	416	6	1	3	4.5	CN(C)CCCCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL135616	26123	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	416	6	1	3	4.5	CN(C)CCCCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL4576555	214017	5	None	-1	19	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		CHEMBL4576555	214017	5	None	-1	19	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
		117773324	132431	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2cc(C3CC3)ccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697572	132431	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2cc(C3CC3)ccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		1218	3616	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		938	3616	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		CHEMBL353335	3616	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		44415611	166259	0	None	54	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	435	2	1	6	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccco3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL426868	166259	0	None	54	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	435	2	1	6	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccco3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11567963	155055	0	None	40	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	419	3	1	5	3.9	COc1cc2c(cc1OC)-c1c(OC)c(O)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL401689	155055	0	None	40	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	419	3	1	5	3.9	COc1cc2c(cc1OC)-c1c(OC)c(O)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		10220	138760	16	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)C1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780481	138760	16	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)C1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		86763997	132473	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697613	132473	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		9884087	14637	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	14637	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		86767098	129430	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		CHEMBL3671287	129430	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		130442572	171908	0	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	171908	0	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44415395	138161	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	423	2	1	5	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL376928	138161	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	423	2	1	5	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		53328901	66481	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1802236	66481	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852245	66481	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		90644226	111779	0	None	-72	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287395	111779	0	None	-72	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		118709179	113426	0	None	-61	4	Pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1198	35	0	18	9.5	O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318851	113426	0	None	-61	4	Pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1198	35	0	18	9.5	O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		681	1465	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		940	1465	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		947	1465	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		CHEMBL59	1465	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		DB00988	1465	72	None	-97	39	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		10546131	100409	0	None	20	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL290149	100409	0	None	20	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
		10476504	33487	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL142020	33487	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		44361021	118786	0	None	-537	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1	10.1021/jm025558r
		CHEMBL342060	118786	0	None	-537	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1	10.1021/jm025558r
		10884046	165369	0	None	-107	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL423735	165369	0	None	-107	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		44436602	145213	0	None	-245	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL391256	145213	0	None	-245	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2007.08.038
		44436598	149295	0	None	-3388	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL394473	149295	0	None	-3388	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		53361302	63850	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		CHEMBL1803049	63850	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		11696910	77747	0	None	-1174	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	395	3	0	5	4.0	Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1	10.1021/jm060166w
		CHEMBL209034	77747	0	None	-1174	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	395	3	0	5	4.0	Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1	10.1021/jm060166w
		53361302	63850	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803049	63850	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		45268292	196687	0	None	-446	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	460	4	1	6	3.5	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL564688	196687	0	None	-446	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	460	4	1	6	3.5	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		71583848	87731	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL2336892	87731	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		137636498	156196	0	None	-660	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	446	7	2	6	3.8	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4064186	156196	0	None	-660	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	446	7	2	6	3.8	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		118709171	113418	0	None	-5	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1085	35	0	8	16.8	O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318843	113418	0	None	-5	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1085	35	0	8	16.8	O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		122189389	123244	0	None	-346	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	497	8	0	8	4.2	O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		CHEMBL3613875	123244	0	None	-346	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	497	8	0	8	4.2	O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		13678304	101713	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	229	3	3	3	2.3	NCCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		CHEMBL299511	101713	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	229	3	3	3	2.3	NCCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		44371996	53623	0	None	-8	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	500	6	0	6	4.6	Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL160266	53623	0	None	-8	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	500	6	0	6	4.6	Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		44371980	53935	0	None	-57	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	514	6	0	6	4.9	Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL160536	53935	0	None	-57	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	514	6	0	6	4.9	Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		44400674	125189	0	None	-3019	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL364516	125189	0	None	-3019	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		44264623	205013	0	None	-1174	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7686	205013	0	None	-1174	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		11659604	138574	0	None	-30	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL377542	138574	0	None	-30	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1	10.1021/jm060166w
		44336552	111340	1	None	-53	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL326864	111340	1	None	-53	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		9977478	204943	2	None	-234422	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	386	6	2	5	2.4	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL76402	204943	2	None	-234422	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	386	6	2	5	2.4	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		56926586	69009	0	None	-2089	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	344	3	1	5	2.6	Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		CHEMBL1923415	69009	0	None	-2089	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	344	3	1	5	2.6	Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		44381217	59146	0	None	-9	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL169889	59146	0	None	-9	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		44371997	49930	0	None	-10000	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	364	3	0	4	3.6	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12	10.1016/s0960-894x(01)00814-9
		CHEMBL156851	49930	0	None	-10000	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	364	3	0	4	3.6	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12	10.1016/s0960-894x(01)00814-9
		154704941	176627	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4578364	176627	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597877	176627	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		167715	2876	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
		969	2876	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
		CHEMBL225230	2876	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
		46231834	200912	0	None	-117	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	488	3	1	5	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCN(c5ccccn5)CC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL601635	200912	0	None	-117	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	488	3	1	5	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCN(c5ccccn5)CC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		10684714	100310	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115372	100310	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL289283	100310	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL5289958	194486	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constantDisplacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constant	ChEMBL	429	4	1	2	5.6	Fc1ccc(CN2CCCC3(CCN(Cc4cc5ccc(Cl)cc5[nH]4)C3)C2)cc1F	10.1016/j.ejmech.2022.114840
		72301	186118	76	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		CHEMBL487182	186118	76	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		44415367	79948	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	411	3	1	5	3.9	CCCC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL212597	79948	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	411	3	1	5	3.9	CCCC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		44401105	69576	0	None	-17	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193435	69576	0	None	-17	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		44320327	163424	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL419680	163424	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		10623632	48294	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	453	4	1	3	5.1	CCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		CHEMBL155351	48294	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	453	4	1	3	5.1	CCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		44326982	8659	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
		CHEMBL109548	8659	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
		CHEMBL545727	8659	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
		9886130	206430	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL87943	206430	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		9886130	206430	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87943	206430	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		131990	43945	11	None	-6	2	Rat	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cnccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL151263	43945	11	None	-6	2	Rat	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cnccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		156018868	177927	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	378	5	1	4	4.0	C=CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4645375	177927	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	378	5	1	4	4.0	C=CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		12050195	203284	0	None	-21	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	6	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64696	203284	0	None	-21	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	6	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		11057	176149	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	176149	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	176149	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	176149	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		117772791	132422	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	323	3	1	5	2.5	Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697563	132422	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	323	3	1	5	2.5	Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44415625	80095	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213145	80095	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		11732785	163720	0	None	-1819	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		CHEMBL420510	163720	0	None	-1819	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		44278409	100334	0	None	-616	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	418	6	0	4	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL28946	100334	0	None	-616	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	418	6	0	4	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		44415543	79950	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212608	79950	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415543	79950	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212608	79950	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		10052433	165357	0	None	-501	4	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	521	10	1	6	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL423671	165357	0	None	-501	4	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	521	10	1	6	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		16090821	81833	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL216439	81833	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		10851717	78477	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	78477	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		1353	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		3559	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		86	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		CHEMBL54	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		DB00502	1911	93	None	-74	83	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		9817779	114433	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		CHEMBL333246	114433	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		1830	2590	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		207	2590	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		23897	2590	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		CHEMBL460	2590	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		DB01618	2590	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		10851717	78477	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	78477	1	None	-15	5	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		44323894	168100	0	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	304	1	0	2	3.9	CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL432762	168100	0	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	304	1	0	2	3.9	CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		15115524	109010	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	735	3	5	8	7.8	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N/C(S)=N/c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)cc2)C1	10.1021/jm00115a012
		CHEMBL321223	109010	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	735	3	5	8	7.8	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N/C(S)=N/c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)cc2)C1	10.1021/jm00115a012
		6761	67799	19	None	-5	18	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	67799	19	None	-5	18	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		44415701	80086	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	569	5	1	8	5.1	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		CHEMBL213110	80086	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	569	5	1	8	5.1	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		44415584	138694	0	None	50	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Br)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL377877	138694	0	None	50	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Br)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415601	141461	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	481	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL384269	141461	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	481	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		156018764	177795	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	2	1	3	3.8	COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2	10.1016/j.bmcl.2020.127305
		CHEMBL4643426	177795	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	2	1	3	3.8	COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2	10.1016/j.bmcl.2020.127305
		9844271	130682	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL368324	130682	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9884087	14637	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	14637	0	None	-5	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		9844271	130682	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL368324	130682	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9844271	130682	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL368324	130682	1	None	1	5	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		11716449	141215	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
		CHEMBL382850	141215	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
		72699815	115196	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	349	3	1	4	3.9	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344467	115196	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	349	3	1	4	3.9	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		117773776	132459	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	3	1	5	3.9	Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697599	132459	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	3	1	5	3.9	Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		9817779	114433	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		CHEMBL333246	114433	0	None	-2	3	Rat	6.8	pKi	=	6.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		45269168	195930	0	None	-10	4	Bovine	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	410	4	1	6	2.3	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL559399	195930	0	None	-10	4	Bovine	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	410	4	1	6	2.3	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		122189390	123245	0	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	6	0	8	3.4	O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		CHEMBL3613876	123245	0	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	6	0	8	3.4	O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		10973768	107560	0	None	-4073	9	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	563	6	1	8	4.4	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL318901	107560	0	None	-4073	9	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	563	6	1	8	4.4	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		681	1465	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	1465	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	1465	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	1465	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	1465	72	None	-23	39	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		10403608	78160	5	None	-1584	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL210405	78160	5	None	-1584	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		44412468	165930	0	None	-616	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL425057	165930	0	None	-616	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		53317282	58598	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684131	58598	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		24949534	189518	0	None	-2041	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		CHEMBL514074	189518	0	None	-2041	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		10403608	78160	5	None	-1584	6	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL210405	78160	5	None	-1584	6	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		145979897	166606	0	None	-158	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	480	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4280542	166606	0	None	-158	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	480	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2	10.1021/acsmedchemlett.8b00229
		57400556	69310	0	None	-2398	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	3.1	CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928134	69310	0	None	-2398	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	3.1	CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		10476504	33487	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1016/j.bmc.2017.04.036
		CHEMBL142020	33487	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1016/j.bmc.2017.04.036
		10824155	57240	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	243	5	0	1	3.6	C#CC(C#C)=C1CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		CHEMBL165022	57240	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	243	5	0	1	3.6	C#CC(C#C)=C1CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		44436601	91943	0	None	-1584	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1	10.1016/j.bmc.2007.08.038
		CHEMBL241424	91943	0	None	-1584	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1	10.1016/j.bmc.2007.08.038
		15508238	4795	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	340	3	0	2	4.7	C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/s0960-894x(99)00540-5
		CHEMBL104092	4795	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	340	3	0	2	4.7	C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/s0960-894x(99)00540-5
		72544787	93130	0	None	-501	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	587	12	3	12	1.2	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443008	93130	0	None	-501	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	587	12	3	12	1.2	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		57400562	69318	0	None	-16	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928247	69318	0	None	-16	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1	10.1016/j.bmc.2011.10.063
		71449034	78423	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111526	78423	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		44319361	205720	0	None	-7	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL82527	205720	0	None	-7	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		10200496	83593	0	None	-295	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
		CHEMBL2204343	83593	0	None	-295	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
		11653679	181191	1	None	-24	11	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL476108	181191	1	None	-24	11	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		9872676	78195	0	None	-4073	16	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
		CHEMBL210514	78195	0	None	-4073	16	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
		11419055	129304	0	None	-24	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	431	4	1	5	3.0	O=C1NCCN1CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL367087	129304	0	None	-24	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	431	4	1	5	3.0	O=C1NCCN1CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		10335576	120931	5	None	2	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3ccccc3Sc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL356076	120931	5	None	2	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3ccccc3Sc3ncccc32)CC1	10.1021/jm00030a011
		44278267	100264	0	None	-53	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	368	6	0	2	4.6	O=C1c2ccccc2CN1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL28884	100264	0	None	-53	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	368	6	0	2	4.6	O=C1c2ccccc2CN1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		16090821	81833	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
		CHEMBL216439	81833	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
		46889212	7469	0	None	-263	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccncc1	10.1016/j.bmcl.2010.02.106
		CHEMBL1086958	7469	0	None	-263	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccncc1	10.1016/j.bmcl.2010.02.106
		13678338	100722	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.8	Oc1ccc(-c2c(O)c(O)c(Cl)c3c2CCNCC3)cc1	10.1021/jm00160a018
		CHEMBL292611	100722	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.8	Oc1ccc(-c2c(O)c(O)c(Cl)c3c2CCNCC3)cc1	10.1021/jm00160a018
		14198580	197962	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	301	3	0	2	4.1	COc1cc2c(cc1Cl)CCN(C)C2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL573412	197962	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	301	3	0	2	4.1	COc1cc2c(cc1Cl)CCN(C)C2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		154725766	176645	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4527244	176645	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4598000	176645	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		10546132	161255	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL41196	161255	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		44299852	198135	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	245	3	4	4	2.0	NCCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		CHEMBL57470	198135	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	245	3	4	4	2.0	NCCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		11346967	125427	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	3	3.4	O=C(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		CHEMBL364586	125427	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	3	3.4	O=C(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		11812345	16913	0	None	-213	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		CHEMBL125193	16913	0	None	-213	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		15711860	13858	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1195937	13858	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL555619	13858	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		15069443	100971	0	None	3	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@H]21	10.1021/jm00128a038
		CHEMBL294215	100971	0	None	3	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@H]21	10.1021/jm00128a038
		154726922	176541	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4442936	176541	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597157	176541	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		15696481	79666	0	None	21	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL2115213	79666	0	None	21	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		11404156	66282	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	311	6	0	3	3.4	CC1CN(CCOc2ccccc2Cc2ccccc2)CCO1	10.1021/jm049720x
		CHEMBL184724	66282	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	311	6	0	3	3.4	CC1CN(CCOc2ccccc2Cc2ccccc2)CCO1	10.1021/jm049720x
		71722295	102467	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397381	102467	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040115	102467	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		145990190	166853	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4285528	166853	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		127035062	136451	0	None	-58	19	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	136451	0	None	-58	19	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		135398737	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		38	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		722	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		CHEMBL42	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		DB00363	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		135398737	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		38	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		722	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		CHEMBL42	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		DB00363	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		24800688	155718	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	309	3	1	3	3.9	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL405345	155718	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	309	3	1	3	3.9	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		10498848	120052	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)cc2c1C(Cc1ccccc1O)N(C)CC2	10.1021/jm991034o
		CHEMBL350471	120052	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)cc2c1C(Cc1ccccc1O)N(C)CC2	10.1021/jm991034o
		72708061	92199	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425372	92199	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		44582461	181917	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	350	5	0	4	2.3	O=C1c2ccccc2CCN1CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477961	181917	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	350	5	0	4	2.3	O=C1c2ccccc2CCN1CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		70692655	76074	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057456	76074	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		71109804	87506	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	nan
		CHEMBL2334882	87506	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	nan
		70692655	76074	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2057456	76074	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		117772871	132480	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697621	132480	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		74223831	129453	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	2	6	2.1	Cc1c(-c2ccc(Oc3nccc4n[nH]cc34)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3671308	129453	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	2	6	2.1	Cc1c(-c2ccc(Oc3nccc4n[nH]cc34)cc2)n(C)c(=O)[nH]c1=O	nan
		15115518	8937	0	None	-380	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL109787	8937	0	None	-380	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		135398737	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		38	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		722	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		CHEMBL42	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		DB00363	958	93	None	-83	89	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		44447996	155503	0	None	-44	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL404137	155503	0	None	-44	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		145967572	164933	0	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	275	8	1	2	4.5	CCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4224763	164933	0	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	275	8	1	2	4.5	CCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		122167	12241	13	None	-56	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards Dopamine receptor D1In vitro binding affinity towards Dopamine receptor D1	ChEMBL	263	5	2	3	3.1	CCCN(CCC)C1CCc2c(ccc(O)c2O)C1	10.1021/jm0307786
		CHEMBL11845	12241	13	None	-56	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards Dopamine receptor D1In vitro binding affinity towards Dopamine receptor D1	ChEMBL	263	5	2	3	3.1	CCCN(CCC)C1CCc2c(ccc(O)c2O)C1	10.1021/jm0307786
		44340302	9752	0	None	-3	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL113471	9752	0	None	-3	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		25139329	187103	0	None	-11	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	514	10	0	4	7.6	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		CHEMBL491466	187103	0	None	-11	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	514	10	0	4	7.6	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		71583848	87731	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL2336892	87731	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		137636460	156120	0	None	-120	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4063282	156120	0	None	-120	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		122189387	123242	0	None	-45	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	417	7	0	8	2.7	COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		CHEMBL3613873	123242	0	None	-45	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	417	7	0	8	2.7	COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		44400594	133575	0	None	-85	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL371165	133575	0	None	-85	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		240	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		2769	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		44279790	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		660	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		CHEMBL1729	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		CHEMBL560739	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		DB00604	944	43	None	-19	24	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		4420454	56259	6	None	-41	5	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		CHEMBL162762	56259	6	None	-41	5	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		10454684	204805	0	None	-5623	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	418	3	0	4	3.3	Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7508	204805	0	None	-5623	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	418	3	0	4	3.3	Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		44340186	9660	0	None	-45	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		CHEMBL112831	9660	0	None	-45	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		137640152	156753	0	None	-10715	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	631	15	3	10	4.0	CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		CHEMBL4070604	156753	0	None	-10715	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	631	15	3	10	4.0	CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		44437897	153053	0	None	-776	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	352	6	1	3	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC	10.1016/j.bmc.2007.07.017
		CHEMBL397592	153053	0	None	-776	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	352	6	1	3	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC	10.1016/j.bmc.2007.07.017
		90644059	112030	0	None	-22	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289643	112030	0	None	-22	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		25132869	103295	0	None	-269	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		CHEMBL3084503	103295	0	None	-269	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		154705296	176394	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4444691	176394	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595970	176394	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		154726793	176233	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4590966	176233	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4594692	176233	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		45481839	198094	0	None	-22	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	4	1	2	3.7	CCCCC1NCCc2cc(Cl)c(OC)cc21	10.1016/j.bmc.2009.05.079
		CHEMBL574418	198094	0	None	-22	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	4	1	2	3.7	CCCCC1NCCc2cc(Cl)c(OC)cc21	10.1016/j.bmc.2009.05.079
		46227284	199715	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
		CHEMBL593394	199715	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
		11351639	60524	0	None	-93	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		CHEMBL175734	60524	0	None	-93	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		44299993	101922	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL301003	101922	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		72708058	92195	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425368	92195	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		25256817	181426	0	None	-169	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	445	6	0	3	5.0	O=C1c2ccccc2CCCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476394	181426	0	None	-169	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	445	6	0	3	5.0	O=C1c2ccccc2CCCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		44582489	189800	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	3.9	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL516270	189800	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	3.9	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		14198596	101643	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	101643	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		145969667	164965	0	None	-30	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4225278	164965	0	None	-30	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		14198596	101643	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL299056	101643	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00118a012
		13678327	202054	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	329	8	3	4	4.1	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		CHEMBL60861	202054	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	329	8	3	4	4.1	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		11151583	129463	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	327	2	1	5	2.6	CN1CCN(C2=Cn3c(CO)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL367180	129463	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	327	2	1	5	2.6	CN1CCN(C2=Cn3c(CO)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		44415738	79894	0	None	22	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	1	1	4	6.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C(=O)Nc3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212384	79894	0	None	22	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	1	1	4	6.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C(=O)Nc3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		135995891	202960	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	413	4	1	5	4.1	Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL62996	202960	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	413	4	1	5	4.1	Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		154726046	176311	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4442408	176311	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595266	176311	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		44582678	181574	0	None	-12	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476839	181574	0	None	-12	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		15696482	79559	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL2114209	79559	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		14198596	101643	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	101643	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		14198600	101891	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL300778	101891	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		14198601	100901	1	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		CHEMBL293828	100901	1	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		44582115	181675	0	None	-154	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	6	0	3	4.6	O=C1c2ccccc2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477646	181675	0	None	-154	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	6	0	3	4.6	O=C1c2ccccc2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		180	401	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	401	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	401	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	401	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	401	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		130907	194683	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL53294	194683	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		1704	3522	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		4331799	3522	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		CHEMBL1334465	3522	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		23656545	146770	0	None	-83	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	3	3.5	COc1cc2c3c(c1)-c1c(ccc(C)c1O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2007.05.057
		CHEMBL392447	146770	0	None	-83	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	3	3.5	COc1cc2c3c(c1)-c1c(ccc(C)c1O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2007.05.057
		14198600	101891	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL300778	101891	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		1212	1662	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		204	1662	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		3372	1662	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		CHEMBL726	1662	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		DB00623	1662	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		14198601	100901	1	None	-1	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		CHEMBL293828	100901	1	None	-1	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		13678309	194926	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	255	1	3	3	2.5	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2	10.1021/jm00160a018
		CHEMBL54168	194926	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	255	1	3	3	2.5	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2	10.1021/jm00160a018
		3036864	202754	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	202754	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	202754	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	202754	19	None	-26	28	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		10084583	104778	4	None	-33	6	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		CHEMBL310867	104778	4	None	-33	6	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		5281878	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		5281881	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		948	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		968	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		CHEMBL42055	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		CHEMBL54661	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		DB00875	1660	35	None	-34	17	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		44578927	189662	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	335	4	0	3	4.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CC)c1-3	10.1016/j.bmc.2008.08.056
		CHEMBL515187	189662	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	335	4	0	3	4.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CC)c1-3	10.1016/j.bmc.2008.08.056
		11976	920	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		667467	920	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		CHEMBL908	920	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		DB01239	920	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		10684714	100310	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115372	100310	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL289283	100310	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		9796958	146578	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115374	146578	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL39230	146578	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL544814	146578	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10684715	160640	0	None	11	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL41132	160640	0	None	11	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		11089340	12888	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	2	0	4	4.0	CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL118889	12888	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	2	0	4	4.0	CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		17756101	98584	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		CHEMBL276778	98584	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		86764103	132437	13	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697578	132437	13	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		10457445	103193	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		CHEMBL308295	103193	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		10656804	116559	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL336366	116559	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		1621	2429	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		17	2429	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		5761	2429	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		CHEMBL263881	2429	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		DB04829	2429	17	None	-112	45	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		44276414	97628	0	None	12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL27101	97628	0	None	12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		45482169	197838	0	None	-6	4	Pig	6.8	pKi	=	6.8	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	559	12	1	8	4.5	O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2009.06.041
		CHEMBL572379	197838	0	None	-6	4	Pig	6.8	pKi	=	6.8	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	559	12	1	8	4.5	O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2009.06.041
		135398737	958	93	None	-44	89	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		38	958	93	None	-44	89	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		722	958	93	None	-44	89	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		CHEMBL42	958	93	None	-44	89	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		DB00363	958	93	None	-44	89	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		44209472	70172	2	None	-97	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940420	70172	2	None	-97	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		90644228	111786	0	None	-29	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287402	111786	0	None	-29	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		11092112	207628	0	None	-3162	8	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	485	6	0	6	4.9	O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		CHEMBL95175	207628	0	None	-3162	8	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	485	6	0	6	4.9	O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		44403232	71076	0	None	-112	5	Pig	5.8	pKi	=	5.8	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	459	8	1	4	4.0	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		CHEMBL195247	71076	0	None	-112	5	Pig	5.8	pKi	=	5.8	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	459	8	1	4	4.0	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		44436610	91949	0	None	-234	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL241436	91949	0	None	-234	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		130907	194683	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL53294	194683	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		52937680	61173	0	None	-3235	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	466	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1	10.1021/jm101639t
		CHEMBL1765632	61173	0	None	-3235	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	466	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1	10.1021/jm101639t
		137659990	159230	0	None	-3019	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4098859	159230	0	None	-3019	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		57393627	69307	0	None	-199	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1101	42	2	17	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928131	69307	0	None	-199	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1101	42	2	17	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		11077918	206594	0	None	-13	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1	10.1021/jm015522j
		CHEMBL88937	206594	0	None	-13	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1	10.1021/jm015522j
		46869265	16257	0	None	-4	7	Human	4.8	pKi	=	4.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		CHEMBL1224527	16257	0	None	-4	7	Human	4.8	pKi	=	4.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		73353534	91058	0	None	-4168	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		CHEMBL2397477	91058	0	None	-4168	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		71733932	91052	0	None	-24547	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		CHEMBL2397389	91052	0	None	-24547	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		23642427	91799	0	None	-38904	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	430	7	1	4	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL241169	91799	0	None	-38904	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	430	7	1	4	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		24824061	97897	0	None	-25	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		CHEMBL272396	97897	0	None	-25	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		10021692	146382	19	None	-23442	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	364	10	1	4	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL392158	146382	19	None	-23442	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	364	10	1	4	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		132060743	162236	0	None	-7	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4163428	162236	0	None	-7	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		145969667	164965	0	None	-30	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4225278	164965	0	None	-30	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		228	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		33	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		6005	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		CHEMBL53	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		DB00714	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		11559090	155561	0	None	-60	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	335	1	2	3	3.8	CC1(c2cccc(O)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		CHEMBL404352	155561	0	None	-60	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	335	1	2	3	3.8	CC1(c2cccc(O)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		44567689	183809	0	None	-7	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	309	3	1	3	3.9	CCCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		CHEMBL480525	183809	0	None	-7	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	309	3	1	3	3.9	CCCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		145979855	166528	0	None	-83	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	405	7	2	5	3.5	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4279136	166528	0	None	-83	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	405	7	2	5	3.5	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2	10.1021/acsmedchemlett.8b00229
		72708058	92195	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425368	92195	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		70690497	76063	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057438	76063	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		70690497	76063	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL2057438	76063	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		681	1465	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		940	1465	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		947	1465	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		CHEMBL59	1465	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		DB00988	1465	72	None	-154	39	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		13903144	100086	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
		CHEMBL1743798	100086	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
		CHEMBL287332	100086	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
		46227317	200163	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		CHEMBL596448	200163	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		45379377	7457	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
		CHEMBL1086790	7457	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
		10107367	102434	1	None	-7	4	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL303993	102434	1	None	-7	4	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		11777127	25810	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL135318	25810	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		117773975	132434	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	367	4	1	6	2.9	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1C	nan
		CHEMBL3697575	132434	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	367	4	1	6	2.9	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1C	nan
		4011	82408	49	None	-64	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	82408	49	None	-64	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		71722293	102475	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
		CHEMBL2397380	102475	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
		CHEMBL3040164	102475	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
		135398737	958	93	None	-44	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		38	958	93	None	-44	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		722	958	93	None	-44	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		CHEMBL42	958	93	None	-44	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		DB00363	958	93	None	-44	89	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		60165416	75296	0	None	-478	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL2037431	75296	0	None	-478	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		44439944	151869	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2	10.1016/j.bmcl.2006.11.093
		CHEMBL396561	151869	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2	10.1016/j.bmcl.2006.11.093
		49782600	17453	0	None	-4	5	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	1	3	4.4	Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1257689	17453	0	None	-4	5	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	1	3	4.4	Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		127031397	138730	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	397	7	1	5	4.6	CCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3780140	138730	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	397	7	1	5	4.6	CCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		44401106	124327	0	None	-29	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL363581	124327	0	None	-29	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		9796255	129048	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL367045	129048	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
		9796255	129048	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm049629t
		CHEMBL367045	129048	0	None	-17	8	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm049629t
		10894826	10486	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL116542	10486	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		9884087	14637	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	14637	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		71733935	90983	0	None	-457	6	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		CHEMBL2396663	90983	0	None	-457	6	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		1242	3613	27	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
		935	3613	27	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL286080	3613	27	None	-5	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
		25110707	12607	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186974	12607	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL485036	12607	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		10594054	31413	1	None	-562	4	Bovine	5.7	pKi	=	5.7	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1	10.1021/jm0009989
		CHEMBL140258	31413	1	None	-562	4	Bovine	5.7	pKi	=	5.7	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1	10.1021/jm0009989
		14198600	101891	2	None	3	2	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL300778	101891	2	None	3	2	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		54583898	61611	0	None	-3801	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	417	7	0	4	3.3	C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		CHEMBL1771114	61611	0	None	-3801	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	417	7	0	4	3.3	C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		44412482	78159	0	None	-4365	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL210404	78159	0	None	-4365	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1	10.1016/j.bmcl.2006.02.075
		17475863	168784	3	None	-660	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL437490	168784	3	None	-660	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		53317208	58555	0	None	-234	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	634	14	0	8	6.4	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCn2cc(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684029	58555	0	None	-234	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	634	14	0	8	6.4	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCn2cc(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		24854106	161061	1	None	-95	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
		CHEMBL411663	161061	1	None	-95	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
		10960333	206984	0	None	-2	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	398	5	0	6	3.5	CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		CHEMBL91362	206984	0	None	-2	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	398	5	0	6	3.5	CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		44339953	109700	0	None	-707	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		CHEMBL322802	109700	0	None	-707	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		21559988	113427	3	None	-30	4	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	389	5	1	3	4.0	O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318852	113427	3	None	-30	4	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	389	5	1	3	4.0	O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2014.06.079
		9797495	69004	0	None	-17378	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	328	3	0	4	2.9	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1	10.1021/jm200762g
		CHEMBL1923292	69004	0	None	-17378	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	328	3	0	4	2.9	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1	10.1021/jm200762g
		44381279	58739	0	None	-41	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL168571	58739	0	None	-41	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		44415837	139539	0	None	5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	3	1	5	5.9	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL379593	139539	0	None	5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	3	1	5	5.9	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		154724369	176689	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4584372	176689	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4598389	176689	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		681	1465	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		940	1465	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		947	1465	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		CHEMBL59	1465	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		DB00988	1465	72	None	-154	39	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		6603800	3548	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		956	3548	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		CHEMBL63321	3548	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		5281148	203909	50	None	5	4	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	260	8	2	2	2.8	C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC	10.1016/j.bmc.2007.12.021
		CHEMBL69018	203909	50	None	5	4	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	260	8	2	2	2.8	C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC	10.1016/j.bmc.2007.12.021
		14198585	100801	1	None	1	4	Rat	4.7	pKi	=	4.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	100801	1	None	1	4	Rat	4.7	pKi	=	4.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		44582705	186996	0	None	-12	13	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490632	186996	0	None	-12	13	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		2351	3286	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	3286	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	3286	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	3286	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	3286	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		12488	1657	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	1657	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	1657	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	1657	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		10338282	34687	1	None	-2	6	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
		CHEMBL143022	34687	1	None	-2	6	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
		13678325	101920	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	313	8	2	3	4.4	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		CHEMBL300995	101920	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	313	8	2	3	4.4	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		6937303	203207	7	None	-43	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	335	4	0	4	4.1	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL64376	203207	7	None	-43	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	335	4	0	4	4.1	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1	10.1016/s0960-894x(00)00405-4
		44278364	99420	0	None	-169	3	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	334	6	0	2	3.9	O=C1c2ccccc2CN1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL282822	99420	0	None	-169	3	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	334	6	0	2	3.9	O=C1c2ccccc2CN1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		68950	127539	12	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	8	0	2	4.0	CCN(CC)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		CHEMBL366265	127539	12	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	8	0	2	4.0	CCN(CC)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		191	403	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	403	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	403	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	403	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	403	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		242	470	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		34	470	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		60795	470	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		CHEMBL1112	470	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		DB01238	470	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		46931072	202045	1	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL608530	202045	1	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		15711870	12956	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1189332	12956	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL538520	12956	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		164610779	185083	0	None	-81	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	558	7	2	5	4.5	COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(I)c(OC)c1)CC2	10.1016/j.bmcl.2021.128047
		CHEMBL4855891	185083	0	None	-81	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	558	7	2	5	4.5	COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(I)c(OC)c1)CC2	10.1016/j.bmcl.2021.128047
		10046389	61416	0	None	-1122	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		CHEMBL177031	61416	0	None	-1122	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		15136	108110	2	None	-154	2	Rat	5.7	pKi	=	5.7	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL319557	108110	2	None	-154	2	Rat	5.7	pKi	=	5.7	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		44432812	87568	0	None	-5	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	3	2	3	3.4	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		CHEMBL233567	87568	0	None	-5	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	3	2	3	3.4	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		154703541	176299	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4541924	176299	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595195	176299	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		11186895	87507	25	None	-5	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmcl.2017.01.090
		CHEMBL2334885	87507	25	None	-5	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmcl.2017.01.090
		1353	1911	93	None	-74	83	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		3559	1911	93	None	-74	83	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		86	1911	93	None	-74	83	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		CHEMBL54	1911	93	None	-74	83	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		DB00502	1911	93	None	-74	83	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		46231589	201301	0	None	999	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNc3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL604108	201301	0	None	999	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNc3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		37459	746	13	None	-10	25	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
		62	746	13	None	-10	25	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
		CHEMBL8514	746	13	None	-10	25	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
		142405827	179865	0	None	-14	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	421	2	1	4	6.1	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4745489	179865	0	None	-14	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	421	2	1	4	6.1	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		142405818	180859	0	None	34	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	367	2	1	4	5.2	COc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4757297	180859	0	None	34	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	367	2	1	4	5.2	COc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		15937728	19995	0	None	288	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C(C2C=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL130328	19995	0	None	288	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C(C2C=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		11623343	140842	1	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		CHEMBL381936	140842	1	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		44415702	139899	0	None	87	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	2	1	5	5.4	Cc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL379942	139899	0	None	87	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	2	1	5	5.4	Cc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		16665071	93401	0	None	-8	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL245764	93401	0	None	-8	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
		10004036	95229	0	None	33	2	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL256075	95229	0	None	33	2	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		71563084	87571	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335736	87571	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		46231847	200574	0	None	3	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	343	1	2	3	3.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL599116	200574	0	None	3	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	343	1	2	3	3.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		6603950	203324	9	None	-3	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64875	203324	9	None	-3	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		6603950	203324	9	None	-3	8	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL64875	203324	9	None	-3	8	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		16090814	81581	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL216258	81581	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		6603950	203324	9	None	-3	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64875	203324	9	None	-3	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		10935201	20884	0	None	758	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.1	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL131054	20884	0	None	758	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.1	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		16090814	81581	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		CHEMBL216258	81581	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		134151764	153144	0	None	31	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	433	4	2	5	4.3	CCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3976659	153144	0	None	31	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	433	4	2	5	4.3	CCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		1238	203174	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64249	203174	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		15115523	108869	1	None	691	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	346	1	2	3	3.4	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N)cc2)C1	10.1021/jm00115a012
		CHEMBL321042	108869	1	None	691	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	346	1	2	3	3.4	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N)cc2)C1	10.1021/jm00115a012
		11315462	200466	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)C4CC4)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL598516	200466	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)C4CC4)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		46231833	200911	0	None	218	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	384	2	2	3	4.3	CCC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL601634	200911	0	None	218	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	384	2	2	3	4.3	CCC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		142405825	179839	0	None	-24	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4745124	179839	0	None	-24	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		134135947	144389	0	None	46	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	5	2	5	4.7	CCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3905947	144389	0	None	46	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	5	2	5	4.7	CCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		37459	746	13	None	-10	25	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
		62	746	13	None	-10	25	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
		CHEMBL8514	746	13	None	-10	25	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
		46231782	200503	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	371	1	1	4	3.8	COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		CHEMBL598730	200503	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	371	1	1	4	3.8	COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		46232064	201348	0	None	707	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	473	2	1	3	6.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(OC(F)(F)F)c4)c3CC[C@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604383	201348	0	None	707	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	473	2	1	3	6.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(OC(F)(F)F)c4)c3CC[C@H]21	10.1016/j.bmcl.2009.12.094
		1238	203174	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64249	203174	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		10662054	84412	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2114444	84412	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2219803	84412	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		146266	100698	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
		CHEMBL292418	100698	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
		CHEMBL540857	100698	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
		46231772	201309	0	None	371	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL604132	201309	0	None	371	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		162676091	183324	0	None	512	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	401	2	1	4	5.7	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(OC(F)(F)F)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4797375	183324	0	None	512	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	401	2	1	4	5.7	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(OC(F)(F)F)ccc1N2	10.1016/j.bmcl.2020.127563
		75202022	170810	2	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		CHEMBL4453318	170810	2	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		10537185	25685	0	None	-12	2	Rat	8.6	pKi	=	8.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135224	25685	0	None	-12	2	Rat	8.6	pKi	=	8.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		44415672	80174	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213492	80174	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		70690500	76073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.12.016
		CHEMBL2057455	76073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.12.016
		70690500	76073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057455	76073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		70690500	76073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	76073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		44415689	139109	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL378669	139109	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		46231846	201339	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	341	1	1	3	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604316	201339	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	341	1	1	3	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		17755867	86109	1	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL231070	86109	1	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		9993922	59966	0	None	3	2	Rat	8.6	pKi	=	8.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	282	1	0	2	3.5	CN1CCc2cccc3c2C(C1)CN3c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		CHEMBL173315	59966	0	None	3	2	Rat	8.6	pKi	=	8.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	282	1	0	2	3.5	CN1CCc2cccc3c2C(C1)CN3c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		46231768	199480	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL591685	199480	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		11439190	201305	0	None	31	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	338	0	1	3	3.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604127	201305	0	None	31	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	338	0	1	3	3.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		37461	17134	14	None	-3	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1016/j.bmcl.2021.128047
		CHEMBL1255588	17134	14	None	-3	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1016/j.bmcl.2021.128047
		44268688	166575	0	None	37	2	Rat	8.5	pKi	=	8.5	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		CHEMBL427996	166575	0	None	37	2	Rat	8.5	pKi	=	8.5	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		4350931	169313	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		CHEMBL441618	169313	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		4350931	169313	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		CHEMBL441618	169313	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		1353	1911	93	None	-74	83	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		3559	1911	93	None	-74	83	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		86	1911	93	None	-74	83	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		CHEMBL54	1911	93	None	-74	83	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		DB00502	1911	93	None	-74	83	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		44331310	107366	1	None	25	3	Human	7.7	pKi	=	7.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		CHEMBL317741	107366	1	None	25	3	Human	7.7	pKi	=	7.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		44415649	138424	0	None	162	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		CHEMBL377420	138424	0	None	162	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		135398745	2914	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		47	2914	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		CHEMBL715	2914	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		DB00334	2914	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		10894826	10486	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL116542	10486	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		10519435	171469	0	None	87	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL446350	171469	0	None	87	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10015045	13652	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
		CHEMBL119455	13652	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
		10015045	13652	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960188q
		CHEMBL119455	13652	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960188q
		10015045	13652	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		CHEMBL119455	13652	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		16103	204638	47	None	-2	4	Rat	6.7	pKi	=	6.7	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00043a008
		CHEMBL73538	204638	47	None	-2	4	Rat	6.7	pKi	=	6.7	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00043a008
		155515982	170010	0	None	-794	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4442460	170010	0	None	-794	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		56833464	68396	0	None	-99	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1138	38	2	16	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		CHEMBL1916720	68396	0	None	-99	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1138	38	2	16	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		14378574	108587	0	None	-7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL320397	108587	0	None	-7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		57390116	69298	0	None	-323	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928122	69298	0	None	-323	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		118709175	113423	0	None	-107	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	474	10	0	5	4.9	CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318848	113423	0	None	-107	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	474	10	0	5	4.9	CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10378194	197765	0	None	-338	6	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	265	3	1	2	2.3	C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		CHEMBL57176	197765	0	None	-338	6	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	265	3	1	2	2.3	C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		10862425	116633	0	None	-467	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1	10.1021/jm025558r
		CHEMBL336930	116633	0	None	-467	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1	10.1021/jm025558r
		10613676	13856	0	None	-165	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1021/jm060959i
		CHEMBL119593	13856	0	None	-165	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1021/jm060959i
		10092819	16773	0	None	-1412	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		CHEMBL124444	16773	0	None	-1412	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		52947756	17170	0	None	-478	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	567	6	0	2	8.3	O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1256170	17170	0	None	-478	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	567	6	0	2	8.3	O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		44319368	106064	0	None	-7	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		CHEMBL313320	106064	0	None	-7	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		44319369	205819	0	None	-11	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		CHEMBL83306	205819	0	None	-11	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		44380802	161691	0	None	-131	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL413343	161691	0	None	-131	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		6469693	79955	17	None	-7079	6	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	322	4	0	5	2.7	COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1	10.1021/jm060166w
		CHEMBL212631	79955	17	None	-7079	6	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	322	4	0	5	2.7	COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1	10.1021/jm060166w
		44319369	205819	0	None	-11	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		CHEMBL83306	205819	0	None	-11	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		2247	505	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	505	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	505	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	505	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	505	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		24949857	181767	0	None	-7413	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		CHEMBL477765	181767	0	None	-7413	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		53318500	58550	0	None	-57	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	630	10	0	7	6.9	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684024	58550	0	None	-57	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	630	10	0	7	6.9	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		2993172	127167	4	None	1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	0	3	3.0	c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1	10.1021/jm049720x
		CHEMBL365697	127167	4	None	1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	0	3	3.0	c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1	10.1021/jm049720x
		134551	358	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	358	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	358	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	358	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		2105	3054	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		47811	3054	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		48	3054	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		CHEMBL531	3054	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		DB01186	3054	37	None	-537	33	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		25212275	174421	0	None	-4897	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL455288	174421	0	None	-4897	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		25212276	190066	0	None	-575	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL517244	190066	0	None	-575	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		135446209	9585	58	None	-22	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
		CHEMBL1125	9585	58	None	-22	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
		71061709	149527	0	None	-14	11	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3946540	149527	0	None	-14	11	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		44582113	181635	0	None	-169	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	364	6	0	4	2.7	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477434	181635	0	None	-169	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	364	6	0	4	2.7	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		10474964	130471	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	130471	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	130471	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		5353853	17986	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	17986	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	17986	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		127262	13480	12	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL1193274	13480	12	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		46227325	200127	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
		CHEMBL596179	200127	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
		71474079	143264	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3896731	143264	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		10550785	163432	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	433	4	1	2	5.9	Oc1cc2c(cc1Br)CCN(C/C=C/c1ccccc1)CC2c1ccccc1	10.1021/jm960143p
		CHEMBL419759	163432	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	433	4	1	2	5.9	Oc1cc2c(cc1Br)CCN(C/C=C/c1ccccc1)CC2c1ccccc1	10.1021/jm960143p
		53359025	62353	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
		CHEMBL1779058	62353	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
		6603703	208	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		9637	208	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		CHEMBL291143	208	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		2389	3331	118	None	-489	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		5073	3331	118	None	-489	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		96	3331	118	None	-489	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		CHEMBL85	3331	118	None	-489	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		DB00734	3331	118	None	-489	67	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		13372	3759	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		86764100	3759	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		CHEMBL3697617	3759	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		DB14899	3759	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		6603820	95774	19	None	-2	13	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
		CHEMBL25856	95774	19	None	-2	13	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
		135398737	958	93	None	-44	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		38	958	93	None	-44	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		722	958	93	None	-44	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		CHEMBL42	958	93	None	-44	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		DB00363	958	93	None	-44	89	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		75201901	166425	19	None	-1	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4277264	166425	19	None	-1	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		17756101	98584	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL276778	98584	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		10903748	78476	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL2111781	78476	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		2435	3590	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		60149	3590	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		98	3590	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		CHEMBL12713	3590	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		DB06144	3590	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		228	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		33	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		6005	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		CHEMBL53	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		DB00714	445	28	None	-30	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		53364153	63841	0	None	-38	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	929	25	0	16	7.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803023	63841	0	None	-38	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	929	25	0	16	7.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		135398737	958	93	None	-83	89	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		38	958	93	None	-83	89	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		722	958	93	None	-83	89	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		CHEMBL42	958	93	None	-83	89	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		DB00363	958	93	None	-83	89	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		52945819	17553	0	None	-14	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	354	6	0	3	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1258037	17553	0	None	-14	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	354	6	0	3	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		127047996	139646	0	None	-46	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	303	8	3	5	2.3	COc1ccccc1OCCNCCc1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		CHEMBL3797758	139646	0	None	-46	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	303	8	3	5	2.3	COc1ccccc1OCCNCCc1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		137636351	155873	0	None	-602	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		CHEMBL4060403	155873	0	None	-602	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		25072002	156114	0	None	-1047	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4063235	156114	0	None	-1047	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		122189388	123243	0	None	-40	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	483	7	0	8	3.8	O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		CHEMBL3613874	123243	0	None	-40	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	483	7	0	8	3.8	O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		44300865	201995	0	None	-173	7	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/s0960-894x(02)00316-5
		CHEMBL60815	201995	0	None	-173	7	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/s0960-894x(02)00316-5
		44340302	9752	0	None	-3	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL113471	9752	0	None	-3	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44340376	110646	0	None	-24	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325818	110646	0	None	-24	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		54581963	61601	0	None	-7762	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	437	8	0	5	3.7	COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		CHEMBL1771105	61601	0	None	-7762	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	437	8	0	5	3.7	COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		44300865	201995	0	None	-173	7	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL60815	201995	0	None	-173	7	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/j.bmcl.2006.02.075
		9980998	31035	0	None	-3981	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		CHEMBL139926	31035	0	None	-3981	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		CHEMBL2112911	31035	0	None	-3981	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		45273442	196451	0	None	-100	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	403	3	0	5	4.3	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL563078	196451	0	None	-100	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	403	3	0	5	4.3	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		44567594	172633	0	None	-34	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	339	4	2	4	4.0	CCCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL449461	172633	0	None	-34	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	339	4	2	4	4.0	CCCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		49783040	17690	0	None	-446	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	395	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1	10.1021/jm100899z
		CHEMBL1258494	17690	0	None	-446	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	395	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1	10.1021/jm100899z
		137660837	159080	0	None	-3019	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4097330	159080	0	None	-3019	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		11154555	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		5037	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		7671	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		CHEMBL2028019	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		CHEMBL3085826	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		DB06016	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		11154555	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		5037	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		7671	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		CHEMBL2028019	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		CHEMBL3085826	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		DB06016	800	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		15723715	13414	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL1192815	13414	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL544118	13414	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
		44316315	205519	0	None	-1318	5	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	215	2	0	3	2.1	CCCN1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		CHEMBL80845	205519	0	None	-1318	5	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	215	2	0	3	2.1	CCCN1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		44264622	97143	4	None	-72	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	327	3	0	5	2.7	Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL267853	97143	4	None	-72	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	327	3	0	5	2.7	Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		44412268	78367	9	None	-2089	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL211026	78367	9	None	-2089	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		72544789	93132	0	None	-912	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	363	9	0	7	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443010	93132	0	None	-912	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	363	9	0	7	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		45379515	7456	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3[nH]c4ccccc4c3C21	10.1021/jm901291r
		CHEMBL1086789	7456	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3[nH]c4ccccc4c3C21	10.1021/jm901291r
		44448027	155030	0	None	2	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	481	4	0	5	4.1	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL401567	155030	0	None	2	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	481	4	0	5	4.1	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		12301195	199716	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.2	COc1ccc2c(c1)CCN1CCc3ccccc3C21	10.1016/j.bmc.2009.08.028
		CHEMBL593395	199716	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.2	COc1ccc2c(c1)CCN1CCc3ccccc3C21	10.1016/j.bmc.2009.08.028
		9817779	114433	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL333246	114433	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		10085633	119996	0	None	-3	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	290	4	1	3	2.4	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCOCC1)CC2	10.1016/0960-894X(95)00076-6
		CHEMBL349997	119996	0	None	-3	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	290	4	1	3	2.4	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCOCC1)CC2	10.1016/0960-894X(95)00076-6
		15654855	102663	0	None	4	2	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3cc(Cl)ccc32)CC1	10.1021/jm00067a009
		CHEMBL304493	102663	0	None	4	2	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3cc(Cl)ccc32)CC1	10.1021/jm00067a009
		2337	3256	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	3256	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	3256	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	3256	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	3256	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		9927411	203053	0	None	-89	4	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL63576	203053	0	None	-89	4	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL4566600	214014	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1	ChEMBL		None	None	None		Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12	10.6019/CHEMBL5212743
		CHEMBL4745071	214014	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1	ChEMBL		None	None	None		Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12	10.6019/CHEMBL5212743
		112500026	132462	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697602	132462	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C	nan
		118711262	113957	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1cccc(-c2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325913	113957	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1cccc(-c2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		9817779	114433	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL333246	114433	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		168290235	192968	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	192968	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	192968	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		9998826	120477	0	None	-33113	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		CHEMBL354210	120477	0	None	-33113	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		2389	3331	118	None	-346	67	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		5073	3331	118	None	-346	67	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		96	3331	118	None	-346	67	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		CHEMBL85	3331	118	None	-346	67	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		DB00734	3331	118	None	-346	67	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		9884087	14637	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	14637	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		44415624	80105	0	None	19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213193	80105	0	None	19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415577	80145	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	436	2	1	7	3.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccon3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213372	80145	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	436	2	1	7	3.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccon3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		25142456	82406	2	None	-10	9	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		CHEMBL217299	82406	2	None	-10	9	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		439654	16498	39	None	9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL1235966	16498	39	None	9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		21527771	70156	1	None	-8	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940404	70156	1	None	-8	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		10903748	78476	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL2111781	78476	0	None	-11	3	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		10830234	100377	0	None	20	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL289867	100377	0	None	20	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		11186523	127511	0	None	-15	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL366164	127511	0	None	-15	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		44408818	140165	1	None	-12	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL380330	140165	1	None	-12	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		53361301	63842	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		CHEMBL1803024	63842	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		54585810	61604	0	None	-22	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771108	61604	0	None	-22	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53361301	63842	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803024	63842	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		53364226	63846	0	None	-67	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	989	29	0	18	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803028	63846	0	None	-67	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	989	29	0	18	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		118709160	113406	0	None	-18	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	846	18	0	8	10.1	O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318832	113406	0	None	-18	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	846	18	0	8	10.1	O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		118709161	113407	0	None	-83	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	860	19	0	8	10.5	O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318833	113407	0	None	-83	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	860	19	0	8	10.5	O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10524751	57354	0	None	-1	4	Bovine	5.7	pKi	=	5.7	Binding	Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	395	5	0	1	6.5	CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1	10.1021/jm991098z
		CHEMBL165171	57354	0	None	-1	4	Bovine	5.7	pKi	=	5.7	Binding	Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	395	5	0	1	6.5	CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1	10.1021/jm991098z
		11036641	31778	0	None	-147	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL140612	31778	0	None	-147	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		11517928	77103	0	None	-18	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	444	4	0	6	4.3	Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		CHEMBL207543	77103	0	None	-18	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	444	4	0	6	4.3	Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		15548770	66450	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1802234	66450	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852041	66450	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		122181333	121874	0	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3590084	121874	0	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		57402365	69295	0	None	-169	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	441	12	1	6	3.1	CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928119	69295	0	None	-169	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	441	12	1	6	3.1	CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		44270558	165288	0	None	-812	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL423247	165288	0	None	-812	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		44400553	70779	0	None	-2398	5	Pig	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL195083	70779	0	None	-2398	5	Pig	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		15467372	169110	0	None	-138	4	Bovine	4.7	pKi	=	4.7	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(99)00302-9
		CHEMBL440120	169110	0	None	-138	4	Bovine	4.7	pKi	=	4.7	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(99)00302-9
		44264644	204743	0	None	-1737	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	330	3	0	4	3.2	Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7442	204743	0	None	-1737	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	330	3	0	4	3.2	Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1	10.1016/s0960-894x(98)00692-1
		45269161	196335	0	None	-181	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	336	3	0	6	2.4	Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL562384	196335	0	None	-181	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	336	3	0	6	2.4	Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		46850462	76562	0	None	-16	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccccc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		CHEMBL2062849	76562	0	None	-16	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccccc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		46850464	76564	0	None	-87	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062851	76564	0	None	-87	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		5353432	97495	89	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		CHEMBL270299	97495	89	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		45481889	199015	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	637	10	2	10	5.4	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5nsc6ccccc56)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		CHEMBL585741	199015	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	637	10	2	10	5.4	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5nsc6ccccc56)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		90644062	112034	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289647	112034	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		90644062	112034	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289647	112034	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		44448065	155480	0	None	-2	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL404037	155480	0	None	-2	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		117773891	132425	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	379	5	1	6	3.1	Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697566	132425	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	379	5	1	6	3.1	Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		145979741	166685	1	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4282096	166685	1	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		46231835	200832	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	410	2	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCCCC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL600998	200832	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	410	2	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCCCC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL1200633	208600	3	None	-7	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		112500027	132463	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697603	132463	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		44320257	206175	0	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL86325	206175	0	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		49783209	17609	0	None	-1148	26	Rat	5.6	pKi	=	5.6	Binding	Binding affinity to rat dopamine D1 receptorBinding affinity to rat dopamine D1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	17609	0	None	-1148	26	Rat	5.6	pKi	=	5.6	Binding	Binding affinity to rat dopamine D1 receptorBinding affinity to rat dopamine D1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		19795148	116590	0	None	97	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	265	0	1	2	3.3	CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL336610	116590	0	None	97	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	265	0	1	2	3.3	CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1	10.1016/S0960-894X(00)80155-9
		44447998	155393	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	363	6	0	3	5.3	CCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL403550	155393	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	363	6	0	3	5.3	CCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415844	80126	0	None	20	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3nccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213278	80126	0	None	20	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3nccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		17756102	86144	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	309	1	0	2	4.1	COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		CHEMBL231171	86144	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	309	1	0	2	4.1	COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		15069442	100701	0	None	104	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		CHEMBL292451	100701	0	None	104	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		71110293	143379	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	143379	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		71110293	143379	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	143379	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		70682088	76068	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057446	76068	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		117773010	132453	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.9	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C	nan
		CHEMBL3697593	132453	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.9	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C	nan
		10947658	28702	0	None	-208	16	Mouse	6.6	pKi	=	6.6	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL137781	28702	0	None	-208	16	Mouse	6.6	pKi	=	6.6	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		6603954	202605	2	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL612083	202605	2	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		11392229	62979	0	None	-15	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	293	1	0	3	2.9	Cc1ccc2n1Cc1ccccc1C=C2N1CCN(C)CC1	10.1021/jm049629t
		CHEMBL178564	62979	0	None	-15	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	293	1	0	3	2.9	Cc1ccc2n1Cc1ccccc1C=C2N1CCN(C)CC1	10.1021/jm049629t
		44360984	35081	0	None	-208	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1	10.1021/jm025558r
		CHEMBL143352	35081	0	None	-208	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1	10.1021/jm025558r
		11516033	139118	5	None	-1949	6	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	360	3	0	4	4.0	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl	10.1021/jm060166w
		CHEMBL378680	139118	5	None	-1949	6	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	360	3	0	4	4.0	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl	10.1021/jm060166w
		54583897	61602	0	None	-1445	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	411	7	0	4	3.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771106	61602	0	None	-1445	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	411	7	0	4	3.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53363109	63848	0	None	-691	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	465	11	0	8	4.0	CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803030	63848	0	None	-691	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	465	11	0	8	4.0	CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		137660046	159343	0	None	-3235	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4100183	159343	0	None	-3235	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
		52937871	61172	0	None	-588	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	458	11	1	5	4.6	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1	10.1021/jm101639t
		CHEMBL1765631	61172	0	None	-588	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	458	11	1	5	4.6	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1	10.1021/jm101639t
		122177644	121212	0	None	-19054	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		CHEMBL3577345	121212	0	None	-19054	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		56926585	69005	0	None	-5495	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	358	4	0	5	2.9	COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		CHEMBL1923293	69005	0	None	-5495	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	358	4	0	5	2.9	COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		44381424	59071	0	None	-190	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL169562	59071	0	None	-190	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		44381432	120718	0	None	-6	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL354748	120718	0	None	-6	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		72301	186118	76	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL487182	186118	76	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		44591134	176200	0	None	-194	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL459373	176200	0	None	-194	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		154726381	176527	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4522558	176527	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4597048	176527	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		90644057	112032	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289645	112032	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		90644057	112032	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289645	112032	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		145992269	166953	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4287192	166953	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
		46227273	199811	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	3	0	2	3.8	COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C	10.1016/j.bmc.2009.08.028
		CHEMBL594127	199811	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	3	0	2	3.8	COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C	10.1016/j.bmc.2009.08.028
		135398737	958	93	None	-83	89	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		38	958	93	None	-83	89	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		722	958	93	None	-83	89	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		CHEMBL42	958	93	None	-83	89	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		DB00363	958	93	None	-83	89	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		14198576	197888	0	None	-2	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	3	1	2	3.8	COc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL572720	197888	0	None	-2	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	3	1	2	3.8	COc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		228	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		33	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		6005	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		CHEMBL53	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		DB00714	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		228	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		33	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		6005	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		CHEMBL53	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		DB00714	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		228	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		33	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		6005	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		CHEMBL53	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		DB00714	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		228	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		33	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		6005	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		CHEMBL53	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		DB00714	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		44415613	78067	0	None	15	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	543	3	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCN(C)CC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL210016	78067	0	None	15	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	543	3	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCN(C)CC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		72708061	92199	0	None	-1	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425372	92199	0	None	-1	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL5274285	193806	0	None	-20	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constantDisplacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constant	ChEMBL	415	4	1	2	5.3	Fc1ccc(CN2CCCC23CCN(Cc2cc4ccc(Cl)cc4[nH]2)C3)cc1F	10.1016/j.ejmech.2022.114840
		44415645	139344	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	613	4	1	7	6.5	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL379286	139344	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	613	4	1	7	6.5	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		44209480	70170	0	None	-218	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940418	70170	0	None	-218	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		10264172	10433	0	None	-7413	2	Rat	4.6	pKi	=	4.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	2	2	3.1	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960188q
		CHEMBL116367	10433	0	None	-7413	2	Rat	4.6	pKi	=	4.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	2	2	3.1	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960188q
		3037308	44079	27	None	-99	6	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	452	7	1	7	4.2	O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm9810396
		CHEMBL151475	44079	27	None	-99	6	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	452	7	1	7	4.2	O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm9810396
		9928073	203649	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL67284	203649	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		10108504	38906	0	None	6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3ccccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL146741	38906	0	None	6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3ccccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		44582518	181593	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.6	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477055	181593	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.6	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		3036864	202754	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	202754	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	202754	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	202754	19	None	-2	28	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		44385451	59592	0	None	-7	2	Rat	7.6	pKi	=	7.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	284	3	0	2	3.9	Cc1cccc2c1C(CN(C)C)CN2c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		CHEMBL171903	59592	0	None	-7	2	Rat	7.6	pKi	=	7.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	284	3	0	2	3.9	Cc1cccc2c1C(CN(C)C)CN2c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		13838745	94732	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		CHEMBL25305	94732	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		1353	1911	93	None	-74	83	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		3559	1911	93	None	-74	83	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		86	1911	93	None	-74	83	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		CHEMBL54	1911	93	None	-74	83	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		DB00502	1911	93	None	-74	83	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		15937721	19105	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	255	2	1	3	2.6	CCOC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL128917	19105	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	255	2	1	3	2.6	CCOC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		44415670	138916	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	565	2	1	5	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL378341	138916	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	565	2	1	5	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415745	166322	0	None	25	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL427230	166322	0	None	25	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		86764211	132446	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697587	132446	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		90140334	129413	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc2n[nH]cc2c(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)n1	nan
		CHEMBL3671270	129413	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc2n[nH]cc2c(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)n1	nan
		44276535	98389	0	None	50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		CHEMBL275379	98389	0	None	50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		10432808	58749	0	None	-6	4	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL168611	58749	0	None	-6	4	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		2389	3331	118	None	-489	67	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	3331	118	None	-489	67	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	3331	118	None	-489	67	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	3331	118	None	-489	67	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	3331	118	None	-489	67	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		10042942	155502	0	None	3	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1OC)-c1c(OC)c(O)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL404136	155502	0	None	3	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1OC)-c1c(OC)c(O)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		137642380	158507	0	None	-48	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
		CHEMBL4091155	158507	0	None	-48	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
		90644227	111780	0	None	-186	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287396	111780	0	None	-186	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		228	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		33	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		6005	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		CHEMBL53	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		DB00714	445	28	None	-30	24	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		9928073	203649	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL67284	203649	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00067a009
		53362716	63962	0	None	-26	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		CHEMBL1806871	63962	0	None	-26	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		49783039	17653	0	None	-954	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	421	7	1	4	4.9	Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1	10.1021/jm100899z
		CHEMBL1258383	17653	0	None	-954	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	421	7	1	4	4.9	Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1	10.1021/jm100899z
		57400557	69312	0	None	-1995	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	509	14	1	8	3.2	CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928136	69312	0	None	-1995	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	509	14	1	8	3.2	CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		15654854	102255	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cccnc3Nc3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL303173	102255	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cccnc3Nc3ccccc32)CC1	10.1021/jm00067a009
		11589069	96247	0	None	-1479	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
		CHEMBL260994	96247	0	None	-1479	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
		15115513	108680	0	None	-218	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL320779	108680	0	None	-218	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		681	1465	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		940	1465	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		947	1465	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		CHEMBL59	1465	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		DB00988	1465	72	None	-154	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		44299917	169449	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@@H]21	10.1021/jm00128a038
		CHEMBL442740	169449	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@@H]21	10.1021/jm00128a038
		90134304	166514	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
		CHEMBL4278861	166514	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
		71562963	87576	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335741	87576	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		10691657	119914	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	387	3	0	3	5.1	CCCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		CHEMBL349311	119914	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	387	3	0	3	5.1	CCCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		168294767	193019	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	193019	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	193019	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		117773347	132427	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	378	4	1	6	2.8	Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697568	132427	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	378	4	1	6	2.8	Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		71110290	147160	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3927835	147160	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		15711860	13858	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1195937	13858	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL555619	13858	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		14198588	171507	2	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL446396	171507	2	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		44320001	206016	0	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL84983	206016	0	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44591135	190177	0	None	-158	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL517407	190177	0	None	-158	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		71110293	143379	0	None	6	3	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	143379	0	None	6	3	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		135398745	2914	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		47	2914	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		CHEMBL715	2914	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		DB00334	2914	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		1353	1911	93	None	-38	83	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		3559	1911	93	None	-38	83	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		86	1911	93	None	-38	83	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		CHEMBL54	1911	93	None	-38	83	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		DB00502	1911	93	None	-38	83	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		1242	3613	27	None	-5	18	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		935	3613	27	None	-5	18	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		CHEMBL286080	3613	27	None	-5	18	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		75306277	109254	0	None	-12	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	109254	0	None	-12	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		9884087	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		71474026	154299	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		CHEMBL3986624	154299	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		11718008	75291	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		CHEMBL203734	75291	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		44415954	81101	0	None	72	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	467	6	1	5	5.4	CCCC(CCC)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL215581	81101	0	None	72	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	467	6	1	5	5.4	CCCC(CCC)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		135398745	2914	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		47	2914	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		CHEMBL715	2914	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		DB00334	2914	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		53364154	63843	0	None	-13	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1013	31	0	16	9.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803025	63843	0	None	-13	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1013	31	0	16	9.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		45273443	195631	0	None	-66	4	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	392	4	1	6	2.2	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL556288	195631	0	None	-66	4	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	392	4	1	6	2.2	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		137644966	158494	0	None	-363	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		CHEMBL4091064	158494	0	None	-363	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		122191607	123722	0	None	-346	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
		CHEMBL3622099	123722	0	None	-346	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
		56837636	69297	0	None	-177	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	897	28	2	13	5.1	COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928121	69297	0	None	-177	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	897	28	2	13	5.1	COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		44401042	124829	0	None	-67	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL364270	124829	0	None	-67	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		11575799	78129	0	None	-2511	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	438	3	0	4	4.7	Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		CHEMBL210341	78129	0	None	-2511	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	438	3	0	4	4.7	Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		25256814	181612	0	None	-1318	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL477250	181612	0	None	-1318	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53363110	63851	0	None	-194	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	507	14	0	8	4.8	CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803050	63851	0	None	-194	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	507	14	0	8	4.8	CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		24823922	160793	0	None	-15	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		CHEMBL411437	160793	0	None	-15	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		11725531	54054	2	None	-1659	5	Bovine	5.6	pKi	=	5.6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	351	3	0	5	3.2	N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL160626	54054	2	None	-1659	5	Bovine	5.6	pKi	=	5.6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	351	3	0	5	3.2	N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		15522515	98161	0	None	-1479	4	Bovine	4.6	pKi	=	4.6	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	292	3	0	4	2.7	c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL273860	98161	0	None	-1479	4	Bovine	4.6	pKi	=	4.6	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	292	3	0	4	2.7	c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		71734028	91053	0	None	-7762	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		CHEMBL2397390	91053	0	None	-7762	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		2389	3331	118	None	-346	67	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		5073	3331	118	None	-346	67	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		96	3331	118	None	-346	67	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		CHEMBL85	3331	118	None	-346	67	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		DB00734	3331	118	None	-346	67	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		44320002	107041	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL315535	107041	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44582491	181555	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	6	0	4	3.3	COc1ccccc1N1CCN(CCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476641	181555	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	6	0	4	3.3	COc1ccccc1N1CCN(CCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		10022123	53316	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL159969	53316	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL92673	53316	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
		71562966	87573	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		CHEMBL2335738	87573	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		44478261	192297	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	0	3	6	3.0	CN1CCc2c3c(cc4nc(N)sc24)-c2c(ccc(O)c2O)C[C@H]31	10.1016/j.bmc.2008.05.077
		CHEMBL520610	192297	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	0	3	6	3.0	CN1CCc2c3c(cc4nc(N)sc24)-c2c(ccc(O)c2O)C[C@H]31	10.1016/j.bmc.2008.05.077
		175	3655	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
		68186	3655	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
		CHEMBL79834	3655	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
		145988779	167279	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
		CHEMBL4293356	167279	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
		72164182	92150	0	None	-41	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
		CHEMBL2420777	92150	0	None	-41	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
		10092819	16773	0	None	-2454	12	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		CHEMBL124444	16773	0	None	-2454	12	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		44415647	139240	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	639	5	1	6	7.6	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL378893	139240	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	639	5	1	6	7.6	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		164612037	185377	0	None	-144	20	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	185377	0	None	-144	20	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		57396484	70169	2	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	316	6	0	5	2.2	Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940417	70169	2	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	316	6	0	5	2.2	Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		13015797	205897	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	400	6	0	5	3.7	COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2	10.1021/jm960084f
		CHEMBL83915	205897	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	400	6	0	5	3.7	COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2	10.1021/jm960084f
		44415836	80136	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	4	1	5	5.9	CCCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213335	80136	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	4	1	5	5.9	CCCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		70607606	177204	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	333	1	3	3	3.1	Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4635277	177204	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	333	1	3	3	3.1	Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		6852376	91599	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		CHEMBL1467585	91599	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		CHEMBL24077	91599	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		CHEMBL503958	91599	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		72699812	115186	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	315	2	1	4	3.7	CCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344456	115186	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	315	2	1	4	3.7	CCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		10566865	115979	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL335515	115979	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		10015045	13652	1	None	-2	6	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL119455	13652	1	None	-2	6	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		86764215	132457	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697597	132457	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		14198587	203131	1	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm00129a006
		CHEMBL64117	203131	1	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm00129a006
		11728201	13979	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL119687	13979	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9884087	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL120512	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		15115514	9071	0	None	-54	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL109897	9071	0	None	-54	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		90644061	112033	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289646	112033	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		136056636	111788	0	None	-309	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287404	111788	0	None	-309	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		118709174	113422	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	946	23	0	10	9.6	CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318847	113422	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	946	23	0	10	9.6	CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10917953	207988	0	None	-7585	9	Rat	5.6	pKi	=	5.6	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	489	6	0	8	3.6	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL97242	207988	0	None	-7585	9	Rat	5.6	pKi	=	5.6	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	489	6	0	8	3.6	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		71583849	87732	0	None	-147	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL2336893	87732	0	None	-147	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1	10.1016/j.bmc.2013.01.065
		14659268	79638	2	None	-35	3	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL2115032	79638	2	None	-35	3	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1016/j.bmc.2008.02.038
		122180956	121771	0	None	-263	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	404	7	1	3	4.8	CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3589577	121771	0	None	-263	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	404	7	1	3	4.8	CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		122177641	121209	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		CHEMBL3577342	121209	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		72544566	93131	0	None	-1318	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	375	10	0	6	3.1	COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443009	93131	0	None	-1318	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	375	10	0	6	3.1	COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		9865384	173495	35	None	-30902	7	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
		CHEMBL45305	173495	35	None	-30902	7	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
		10014924	107271	0	None	-1548	5	Bovine	4.6	pKi	=	4.6	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL316983	107271	0	None	-1548	5	Bovine	4.6	pKi	=	4.6	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		11472028	66767	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	1	3	3.2	OC(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		CHEMBL185875	66767	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	1	3	3.2	OC(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		15711855	13412	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192799	13412	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL544099	13412	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		11696813	187918	12	None	-316	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm100294b
		CHEMBL496739	187918	12	None	-316	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm100294b
		90644061	112033	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289646	112033	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		72708126	92202	0	None	-7	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425375	92202	0	None	-7	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		14198588	171507	2	None	2	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		CHEMBL446396	171507	2	None	2	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		57401706	70171	0	None	-45	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940419	70171	0	None	-45	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		44320218	206424	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
		CHEMBL87897	206424	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
		10993765	78767	0	None	-36	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	433	5	0	5	4.1	COc1ccccc1N1CCN(CC2CCN(C(=O)c3cc4ccccc4o3)CC2)CC1	10.1021/jm0211220
		CHEMBL2112643	78767	0	None	-36	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	433	5	0	5	4.1	COc1ccccc1N1CCN(CC2CCN(C(=O)c3cc4ccccc4o3)CC2)CC1	10.1021/jm0211220
		91899757	129440	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-n1c(C)nc2cnccc21	nan
		CHEMBL3671296	129440	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-n1c(C)nc2cnccc21	nan
		1971	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	2866	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		25256816	181608	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477206	181608	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		9884087	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		21533446	70155	0	None	-7	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940403	70155	0	None	-7	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		11728201	13979	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL119687	13979	0	None	-7	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9884087	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL120512	14637	0	None	-5	3	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		70684965	77834	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL2092940	77834	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		1353	1911	93	None	-38	83	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		3559	1911	93	None	-38	83	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		86	1911	93	None	-38	83	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		CHEMBL54	1911	93	None	-38	83	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		DB00502	1911	93	None	-38	83	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		44249745	195443	1	None	-363	6	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
		CHEMBL552373	195443	1	None	-363	6	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
		CHEMBL567286	195443	1	None	-363	6	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
		24878061	141411	0	None	25	2	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
		CHEMBL384046	141411	0	None	25	2	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
		10061323	11906	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL118254	11906	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		53364227	63847	0	None	-50	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1033	32	0	19	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803029	63847	0	None	-50	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1033	32	0	19	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		10061323	11906	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL118254	11906	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		11405107	199063	0	None	-32	4	Bovine	5.6	pKi	=	5.6	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	341	3	1	2	3.7	C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1	10.1016/s0960-894x(02)00316-5
		CHEMBL58662	199063	0	None	-32	4	Bovine	5.6	pKi	=	5.6	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	341	3	1	2	3.7	C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1	10.1016/s0960-894x(02)00316-5
		44403210	70543	0	None	-630	5	Pig	5.6	pKi	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	385	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL194727	70543	0	None	-630	5	Pig	5.6	pKi	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	385	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		9970201	170643	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		CHEMBL445129	170643	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		52938728	58554	0	None	-1000	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684028	58554	0	None	-1000	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		137636066	156233	0	None	-1698	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4064742	156233	0	None	-1698	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		4150	788	39	None	-69	11	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		5288	788	39	None	-69	11	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		644019	788	39	None	-69	11	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		CHEMBL190461	788	39	None	-69	11	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		DB09061	788	39	None	-69	11	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		11689612	79839	0	None	-28840	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	388	5	0	7	2.9	COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1	10.1021/jm060166w
		CHEMBL212160	79839	0	None	-28840	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	388	5	0	7	2.9	COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1	10.1021/jm060166w
		44412269	78100	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL210232	78100	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2006.02.075
		44412269	78100	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL210232	78100	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		45271653	195235	0	None	-2238	4	Bovine	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1	10.1016/j.bmc.2009.05.015
		CHEMBL550920	195235	0	None	-2238	4	Bovine	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1	10.1016/j.bmc.2009.05.015
		10046389	61416	0	None	-1122	5	Bovine	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		CHEMBL177031	61416	0	None	-1122	5	Bovine	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		135	2532	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	2532	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	2532	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	2532	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	2532	43	None	-91	58	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		44406077	132818	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		CHEMBL370136	132818	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		90644071	112042	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289655	112042	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		131396	206735	6	None	-549	5	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandCompound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligand	ChEMBL	435	6	0	5	4.6	CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1	10.1021/jm00092a024
		CHEMBL89934	206735	6	None	-549	5	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandCompound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligand	ChEMBL	435	6	0	5	4.6	CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1	10.1021/jm00092a024
		118711255	113953	0	None	-26	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(NCc3cccc(Cl)c3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325905	113953	0	None	-26	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(NCc3cccc(Cl)c3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		45269964	13621	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1194295	13621	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL550180	13621	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		10825256	10178	0	None	-6	3	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	260	0	0	2	3.3	CN1CCc2cccc3c2[C@H]1Cc1cccc(C#N)c1-3	10.1021/jm960189i
		CHEMBL115969	10178	0	None	-6	3	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	260	0	0	2	3.3	CN1CCc2cccc3c2[C@H]1Cc1cccc(C#N)c1-3	10.1021/jm960189i
		44432811	87567	0	None	-5	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	323	3	1	3	4.2	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		CHEMBL233566	87567	0	None	-5	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	323	3	1	3	4.2	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		44366021	121027	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		CHEMBL356597	121027	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		44415559	80163	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213444	80163	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415673	139244	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	545	4	1	7	6.1	CCOc1c(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)sc2ccccc12	10.1016/j.bmcl.2006.06.022
		CHEMBL378914	139244	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	545	4	1	7	6.1	CCOc1c(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)sc2ccccc12	10.1016/j.bmcl.2006.06.022
		16104	161917	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL415300	161917	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		74223830	129450	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671305	129450	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		16104	161917	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL415300	161917	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		17755999	142885	1	None	-5	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL389357	142885	1	None	-5	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		86767095	129427	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	345	3	1	5	4.1	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671284	129427	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	345	3	1	5	4.1	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		10566865	115979	0	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL335515	115979	0	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		44408818	140165	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
		CHEMBL380330	140165	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
		44408818	140165	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2006.11.093
		CHEMBL380330	140165	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2006.11.093
		44408818	140165	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmc.2009.08.028
		CHEMBL380330	140165	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmc.2009.08.028
		45379370	7523	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
		CHEMBL1087301	7523	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
		10090424	34697	1	None	-3	6	Rat	7.5	pKi	=	7.5	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
		CHEMBL143027	34697	1	None	-3	6	Rat	7.5	pKi	=	7.5	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
		70692656	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2057457	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.12.016
		70692656	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057457	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692656	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057457	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		70692656	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057457	76075	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		44276651	99740	0	None	32	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL284959	99740	0	None	32	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		15225749	80685	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	341	0	1	5	3.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(N)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL215140	80685	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	341	0	1	5	3.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(N)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		137651073	157468	0	None	-53	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4079301	157468	0	None	-53	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		118709162	113408	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	874	20	0	8	10.9	O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318834	113408	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	874	20	0	8	10.9	O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10689581	100163	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL287931	100163	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		44380770	165712	0	None	-91	4	Bovine	5.6	pKi	=	5.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL424575	165712	0	None	-91	4	Bovine	5.6	pKi	=	5.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		11706497	78177	0	None	-776	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		CHEMBL210461	78177	0	None	-776	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		56833379	68334	0	None	-234	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1155	37	2	18	8.6	COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		CHEMBL1916550	68334	0	None	-234	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1155	37	2	18	8.6	COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		44340415	8578	0	None	-3	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL109472	8578	0	None	-3	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		127045854	139564	0	None	-218	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3797205	139564	0	None	-218	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		127046949	139909	0	None	-446	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	472	12	3	5	4.6	COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3799455	139909	0	None	-446	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	472	12	3	5	4.6	COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		24936042	157589	0	None	-218	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4080762	157589	0	None	-218	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		57390115	69296	0	None	-575	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.4	CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928120	69296	0	None	-575	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.4	CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		24824065	97951	0	None	-1	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		CHEMBL272602	97951	0	None	-1	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		10404144	205302	23	None	-2187	10	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		CHEMBL7927	205302	23	None	-2187	10	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		14198593	198674	1	None	4	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		CHEMBL57988	198674	1	None	4	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		14198594	200103	1	None	6	2	Human	6.6	pKi	=	6.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNC[C@H]2c1ccccc1	10.1021/jm00129a006
		CHEMBL59603	200103	1	None	6	2	Human	6.6	pKi	=	6.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNC[C@H]2c1ccccc1	10.1021/jm00129a006
		44582178	181259	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	378	6	0	4	3.1	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476185	181259	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	378	6	0	4	3.1	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		9951008	206397	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL87717	206397	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm981094e
		9951008	206397	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87717	206397	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm00042a009
		3561	19077	39	None	-1	11	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	19077	39	None	-1	11	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		15711852	13339	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192193	13339	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL543389	13339	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		5041	3294	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
		981	3294	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
		CHEMBL4096543	3294	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
		15711851	13540	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL1193797	13540	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL545264	13540	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		14198586	201833	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		CHEMBL60706	201833	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		91899758	129441	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cc(=O)[nH]nc1C	nan
		CHEMBL3671297	129441	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cc(=O)[nH]nc1C	nan
		117773787	132441	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.7	Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697582	132441	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.7	Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10333195	48186	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		CHEMBL155208	48186	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		1353	1911	93	None	-74	83	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		3559	1911	93	None	-74	83	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		86	1911	93	None	-74	83	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		CHEMBL54	1911	93	None	-74	83	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		DB00502	1911	93	None	-74	83	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		103	4153	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		2875	4153	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		5736	4153	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		CHEMBL285802	4153	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		DB09225	4153	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		10379766	4906	0	None	14	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.2	CCc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		CHEMBL104571	4906	0	None	14	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.2	CCc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		17755999	142885	1	None	-5	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1021/jm070388+
		CHEMBL389357	142885	1	None	-5	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1021/jm070388+
		86767097	129429	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	359	3	1	5	4.5	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671286	129429	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	359	3	1	5	4.5	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		135398737	958	93	None	-44	89	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		38	958	93	None	-44	89	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		722	958	93	None	-44	89	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL42	958	93	None	-44	89	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB00363	958	93	None	-44	89	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		10472143	119277	0	None	-645	16	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL343755	119277	0	None	-645	16	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		11777127	25810	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL135318	25810	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		228	445	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		33	445	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		6005	445	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		CHEMBL53	445	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		DB00714	445	28	None	-35	24	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		10154	142129	59	None	-58	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL388342	142129	59	None	-58	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		9980998	31035	0	None	-3981	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
		CHEMBL139926	31035	0	None	-3981	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
		CHEMBL2112911	31035	0	None	-3981	8	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
		11697270	77310	0	None	-3467	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	412	5	0	5	4.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1	10.1021/jm060166w
		CHEMBL208274	77310	0	None	-3467	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	412	5	0	5	4.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1	10.1021/jm060166w
		44340376	110646	0	None	-24	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325818	110646	0	None	-24	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		25256816	181608	0	None	-4466	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL477206	181608	0	None	-4466	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		16754	85574	50	None	-67	7	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL228082	85574	50	None	-67	7	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		25139181	184342	0	None	-1513	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
		CHEMBL484358	184342	0	None	-1513	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
		44567587	178235	0	None	-66	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	311	2	2	4	3.2	CCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL465055	178235	0	None	-66	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	311	2	2	4	3.2	CCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		127046951	139902	0	None	-61	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3799427	139902	0	None	-61	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		137633705	156618	0	None	-5370	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
		CHEMBL4069091	156618	0	None	-5370	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
		122177645	121213	0	None	-13803	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		CHEMBL3577346	121213	0	None	-13803	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		57391897	69309	0	None	-301	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	481	12	1	8	2.7	CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928133	69309	0	None	-301	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	481	12	1	8	2.7	CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		57393634	69319	0	None	-26	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928248	69319	0	None	-26	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1016/j.bmc.2011.10.063
		24824063	98001	11	None	-5	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cc4ccccn4n3)CC2)cc1	10.1021/jm701375u
		CHEMBL272853	98001	11	None	-5	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cc4ccccn4n3)CC2)cc1	10.1021/jm701375u
		44381216	120332	0	None	-19054	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL352925	120332	0	None	-19054	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		44329314	207942	0	None	-69	3	Bovine	4.5	pKi	=	4.5	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL96958	207942	0	None	-69	3	Bovine	4.5	pKi	=	4.5	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		154706546	176446	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4452329	176446	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596339	176446	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		17755991	152298	0	None	1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	267	0	2	2	3.1	Oc1ccc2c(c1)CCCNCCc1ccccc1C2	10.1021/jm070388+
		CHEMBL396950	152298	0	None	1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	267	0	2	2	3.1	Oc1ccc2c(c1)CCCNCCc1ccccc1C2	10.1021/jm070388+
		96918	12490	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		CHEMBL1186488	12490	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		118711257	113955	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccccc1CNc1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		CHEMBL3325907	113955	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccccc1CNc1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		44568534	174316	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	265	0	2	3	2.6	CN1CCc2cc(N)cc3c2[C@H]1Cc1cccc(N)c1-3	10.1016/j.bmc.2008.05.077
		CHEMBL455051	174316	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	265	0	2	3	2.6	CN1CCc2cc(N)cc3c2[C@H]1Cc1cccc(N)c1-3	10.1016/j.bmc.2008.05.077
		10438027	66188	0	None	-954	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
		CHEMBL184383	66188	0	None	-954	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
		44415805	81535	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	561	4	1	5	7.1	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(CC3CCCCC3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL216047	81535	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	561	4	1	5	7.1	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(CC3CCCCC3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		96918	12490	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		CHEMBL1186488	12490	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		154704705	176325	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4590356	176325	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4595409	176325	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		10367486	9294	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL110948	9294	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL543613	9294	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		1042	1581	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	1581	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	1581	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	1581	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	1581	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		72708126	92202	0	None	-7	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425375	92202	0	None	-7	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		71450550	83807	0	None	-6	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to D1 dopamine receptorBinding affinity to D1 dopamine receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	83807	0	None	-6	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to D1 dopamine receptorBinding affinity to D1 dopamine receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		736083	162214	17	None	-50	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL416288	162214	17	None	-50	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		10452020	118275	3	None	10	3	Human	8.5	pKi	=	8.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		CHEMBL34095	118275	3	None	10	3	Human	8.5	pKi	=	8.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		10516818	25651	0	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135197	25651	0	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		122324	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
		6077	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
		CHEMBL86931	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
		10467946	48469	4	None	-1	4	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		CHEMBL155596	48469	4	None	-1	4	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		14809027	107029	0	None	257	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL315468	107029	0	None	257	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		122324	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		6077	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		CHEMBL86931	205	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		44415690	80137	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL213336	80137	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		44415690	80137	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213336	80137	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		44415506	80239	0	None	169	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		CHEMBL213793	80239	0	None	169	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		46231845	200733	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	391	0	1	2	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL600083	200733	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	391	0	1	2	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		1153	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		12668023	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		30026874	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		30026875	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		3341	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		6603851	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		933	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		939	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		985	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		CHEMBL1160786	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		CHEMBL1161520	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		CHEMBL588	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		DB00800	1628	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		44401164	69816	0	None	-19	9	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-19	9	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		11573628	74699	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
		CHEMBL203047	74699	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
		46231848	200538	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	396	1	1	3	4.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598949	200538	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	396	1	1	3	4.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3038603	101865	8	None	2	3	Human	8.5	pKi	=	8.5	Binding	The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligandThe compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL300647	101865	8	None	2	3	Human	8.5	pKi	=	8.5	Binding	The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligandThe compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		86763997	132473	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697613	132473	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		11778580	66127	1	None	-5	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
		CHEMBL184050	66127	1	None	-5	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
		11493746	141323	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
		CHEMBL383451	141323	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
		17755867	86109	1	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
		CHEMBL231070	86109	1	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
		44415704	80159	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213424	80159	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		15937717	20647	0	None	346	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	253	2	1	2	3.4	CCCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL130851	20647	0	None	346	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	253	2	1	2	3.4	CCCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		56944383	112119	0	None	-6	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3290012	112119	0	None	-6	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		9861622	199444	5	None	1202	2	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	10.1021/jm00128a038
		CHEMBL59139	199444	5	None	1202	2	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	10.1021/jm00128a038
		44415723	141780	0	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL386122	141780	0	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		6917970	3691	61	None	-1	34	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
		8370	3691	61	None	-1	34	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
		CHEMBL487387	3691	61	None	-1	34	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
		11079319	131800	1	None	-13	3	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	1	0	4	3.9	CN1CCN(C2=Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm0309811
		CHEMBL369367	131800	1	None	-13	3	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	1	0	4	3.9	CN1CCN(C2=Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm0309811
		5249956	73395	1	None	-4	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL201525	73395	1	None	-4	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		44415536	138630	0	None	95	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(I)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL377584	138630	0	None	95	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(I)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		117774127	132423	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697564	132423	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		142405812	181003	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	381	3	1	4	5.6	CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4758966	181003	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	381	3	1	4	5.6	CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		15937730	18951	0	None	478	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	301	1	1	2	3.9	CN1CCc2cc(Cl)c(O)cc2C(C2C=CC=CC=C2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL128649	18951	0	None	478	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	301	1	1	2	3.9	CN1CCc2cc(Cl)c(O)cc2C(C2C=CC=CC=C2)C1	10.1016/S0960-894X(00)80155-9
		44439945	93367	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL245571	93367	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		71474025	145327	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	145327	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		71474025	145327	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	145327	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		44561317	188974	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	1	2	3.4	CCN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL508399	188974	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	1	2	3.4	CCN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		44415593	80247	0	None	-3	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213834	80247	0	None	-3	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		6603703	208	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
		9637	208	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
		CHEMBL291143	208	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
		12668019	10239	8	None	204	3	Human	7.5	pKi	=	7.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/jm9800292
		CHEMBL1160787	10239	8	None	204	3	Human	7.5	pKi	=	7.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/jm9800292
		44415338	155756	0	None	69	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	579	3	1	7	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL405751	155756	0	None	69	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	579	3	1	7	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		6603703	208	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
		9637	208	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
		CHEMBL291143	208	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
		74223723	129415	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	334	3	1	4	4.6	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671272	129415	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	334	3	1	4	4.6	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		44320378	206063	0	None	25	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL85409	206063	0	None	25	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		86764212	132448	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	4	4.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697589	132448	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	4	4.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		9949441	114461	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL333455	114461	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		53364155	63844	0	None	-27	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1041	33	0	16	10.2	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803026	63844	0	None	-27	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1041	33	0	16	10.2	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		71733932	91052	0	None	-416	6	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		CHEMBL2397389	91052	0	None	-416	6	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		145988693	167166	0	None	-12	17	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4291048	167166	0	None	-12	17	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		10310103	107312	0	None	-776	8	Rat	5.5	pKi	=	5.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	425	5	0	5	5.3	N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		CHEMBL317333	107312	0	None	-776	8	Rat	5.5	pKi	=	5.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	425	5	0	5	5.3	N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		3038495	708	37	None	-2041	19	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		7625	708	37	None	-2041	19	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		CHEMBL25236	708	37	None	-2041	19	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		44436600	91802	0	None	-3019	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241212	91802	0	None	-3019	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
		44340227	110641	0	None	-2137	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325772	110641	0	None	-2137	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		10663221	33713	1	None	-60	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1	10.1021/jm0009989
		CHEMBL142217	33713	1	None	-60	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1	10.1021/jm0009989
		11983282	138943	0	None	-5128	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
		CHEMBL378455	138943	0	None	-5128	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
		10333195	48186	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		CHEMBL155208	48186	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		25128757	103304	0	None	-831	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
		CHEMBL3084512	103304	0	None	-831	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
		44448058	155204	0	None	2	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL402517	155204	0	None	2	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		72545007	93122	0	None	-199	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	407	12	0	8	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443000	93122	0	None	-199	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	407	12	0	8	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		24824060	155715	0	None	-12	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		CHEMBL405292	155715	0	None	-12	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		10404663	166861	10	None	-1000	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	334	9	1	3	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC	10.1016/j.bmc.2007.07.017
		CHEMBL428561	166861	10	None	-1000	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	334	9	1	3	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC	10.1016/j.bmc.2007.07.017
		12050198	200254	0	None	-87	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	347	6	1	4	4.1	c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL59702	200254	0	None	-87	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	347	6	1	4	4.1	c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		156012196	177332	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	296	1	2	4	2.7	COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4637246	177332	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	296	1	2	4	2.7	COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		46227242	199930	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	2	1	2	3.5	Cc1ccccc1CC1c2ccc(O)cc2CCN1C	10.1016/j.bmc.2009.08.028
		CHEMBL594798	199930	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	2	1	2	3.5	Cc1ccccc1CC1c2ccc(O)cc2CCN1C	10.1016/j.bmc.2009.08.028
		10809507	119684	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(OC)cc(Br)c2C1Cc1ccccc1O	10.1021/jm991034o
		CHEMBL347243	119684	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(OC)cc(Br)c2C1Cc1ccccc1O	10.1021/jm991034o
		76314268	106434	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115577	106434	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139633	106434	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		188249	39653	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL147463	39653	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL2022280	39653	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		15654862	203651	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ccncc32)CC1	10.1021/jm00067a009
		CHEMBL67298	203651	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ccncc32)CC1	10.1021/jm00067a009
		15654863	203437	0	None	7	2	Rat	5.5	pKi	=	5.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ccncc32)CC1	10.1021/jm00067a009
		CHEMBL65768	203437	0	None	7	2	Rat	5.5	pKi	=	5.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ccncc32)CC1	10.1021/jm00067a009
		15654861	100742	0	None	3	2	Rat	4.5	pKi	=	4.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ncccc32)CC1	10.1021/jm00067a009
		CHEMBL292738	100742	0	None	3	2	Rat	4.5	pKi	=	4.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ncccc32)CC1	10.1021/jm00067a009
		44591099	176190	0	None	-1122	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL459350	176190	0	None	-1122	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		9796958	146578	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL2115374	146578	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL39230	146578	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL544814	146578	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL3215298	211231	13	None	-6	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		681	1465	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		940	1465	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		947	1465	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		CHEMBL59	1465	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		DB00988	1465	72	None	-97	39	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		10474964	130471	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	130471	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	130471	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		10693836	9337	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL111189	9337	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL545488	9337	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		44579031	189835	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	391	8	0	3	6.1	CCCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL516580	189835	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	391	8	0	3	6.1	CCCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415835	139794	0	None	181	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		CHEMBL379875	139794	0	None	181	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		45271622	14031	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197278	14031	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL564909	14031	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		134147903	149427	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	383	6	2	5	4.3	CCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3945856	149427	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	383	6	2	5	4.3	CCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		9949441	114461	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL333455	114461	0	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		117774096	132430	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	5	3.7	Cc1cc(Oc2ncccc2C(C)C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697571	132430	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	5	3.7	Cc1cc(Oc2ncccc2C(C)C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		135398737	958	93	None	-44	89	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		38	958	93	None	-44	89	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		722	958	93	None	-44	89	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		CHEMBL42	958	93	None	-44	89	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		DB00363	958	93	None	-44	89	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		64638	106141	2	None	40	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL313530	106141	2	None	40	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44320053	205773	0	None	257	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL82899	205773	0	None	257	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		44319976	106963	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
		CHEMBL315005	106963	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
		11186895	87507	25	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL2334885	87507	25	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		242	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		34	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		60795	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		CHEMBL1112	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		DB01238	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		242	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		34	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		60795	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		CHEMBL1112	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		DB01238	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		242	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		34	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		60795	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		CHEMBL1112	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		DB01238	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		242	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		34	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		60795	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		CHEMBL1112	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		DB01238	470	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		44436599	91801	0	None	-257	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL241211	91801	0	None	-257	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		136043855	141528	0	None	-389	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	482	2	1	6	5.6	FC1(F)Oc2cccc(CN3CCN(C4=Nc5cc(Cl)ccc5Nc5ccccc54)CC3)c2O1	10.1016/j.bmcl.2006.06.034
		CHEMBL384634	141528	0	None	-389	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	482	2	1	6	5.6	FC1(F)Oc2cccc(CN3CCN(C4=Nc5cc(Cl)ccc5Nc5ccccc54)CC3)c2O1	10.1016/j.bmcl.2006.06.034
		127031949	138755	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	317	7	2	5	2.8	COc1cc(CCN(C)Cc2cccc(O)c2OC)ccc1O	10.1016/j.bmc.2016.03.037
		CHEMBL3780438	138755	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	317	7	2	5	2.8	COc1cc(CCN(C)Cc2cccc(O)c2OC)ccc1O	10.1016/j.bmc.2016.03.037
		4189	206922	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	206922	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	206922	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		117773625	132413	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.4	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O	nan
		CHEMBL3697554	132413	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.4	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O	nan
		44319988	206079	0	None	3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL85552	206079	0	None	3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		156012433	177314	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	326	2	1	5	3.1	COc1cc2c3c(c1O)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4636948	177314	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	326	2	1	5	3.1	COc1cc2c3c(c1O)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		3246545	202474	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL1573438	202474	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL611207	202474	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		44319915	205965	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL84557	205965	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44415848	79909	0	None	40	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212438	79909	0	None	40	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		134150852	151695	0	None	12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	461	6	2	5	5.1	CCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3964242	151695	0	None	12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	461	6	2	5	5.1	CCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		86764320	132469	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697609	132469	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		15711869	13340	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1192194	13340	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL543390	13340	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		6852376	91599	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		CHEMBL1467585	91599	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		CHEMBL24077	91599	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		CHEMBL503958	91599	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		71109986	150633	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		CHEMBL3955446	150633	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		54585811	61610	0	None	-2454	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	418	7	0	5	3.2	COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771113	61610	0	None	-2454	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	418	7	0	5	3.2	COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		49783042	17691	0	None	-112	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	1	3	4.3	Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		CHEMBL1258495	17691	0	None	-112	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	1	3	4.3	Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		10871118	206807	0	None	-489	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1	10.1021/jm015522j
		CHEMBL90374	206807	0	None	-489	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1	10.1021/jm015522j
		10667043	28549	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	7	2	3	4.6	NCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL137637	28549	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	7	2	3	4.6	NCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		44537929	198080	0	None	-53	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(O)c(Cl)cc21	10.1016/j.bmc.2009.05.079
		CHEMBL574296	198080	0	None	-53	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(O)c(Cl)cc21	10.1016/j.bmc.2009.05.079
		2470	3653	50	None	-4168	59	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		3300	3653	50	None	-4168	59	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		5265	3653	50	None	-4168	59	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		99	3653	50	None	-4168	59	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		CHEMBL267930	3653	50	None	-4168	59	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		15021876	103410	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		CHEMBL308480	103410	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		15021876	103410	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm981094e
		CHEMBL308480	103410	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm981094e
		10093238	207617	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	414	8	0	5	3.9	O=C(CCCN1CCN(CCC2Cc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL95112	207617	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	414	8	0	5	3.9	O=C(CCCN1CCN(CCC2Cc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		10738913	204963	0	None	-5	5	Rat	4.5	pKi	=	4.5	Binding	Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
		CHEMBL76480	204963	0	None	-5	5	Rat	4.5	pKi	=	4.5	Binding	Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
		73356845	92204	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425377	92204	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		235224	128155	29	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		CHEMBL36654	128155	29	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		45481864	198134	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	2	2	3.5	Oc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL574695	198134	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	2	2	3.5	Oc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		2402	3370	62	None	-74	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		5095	3370	62	None	-74	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		7295	3370	62	None	-74	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		CHEMBL589	3370	62	None	-74	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		DB00268	3370	62	None	-74	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		44320328	206228	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
		CHEMBL86669	206228	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
		11696813	187918	12	None	-316	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
		CHEMBL496739	187918	12	None	-316	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
		73356845	92204	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425377	92204	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		6603820	95774	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		CHEMBL25856	95774	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		6603820	95774	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL25856	95774	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		15937720	116874	0	None	81	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	271	2	1	3	3.3	CCSC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL338237	116874	0	None	81	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	271	2	1	3	3.3	CCSC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		86763999	132476	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.5	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697616	132476	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.5	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)[nH]c1=O	nan
		45483269	196959	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	426	4	0	7	4.1	CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		CHEMBL566508	196959	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	426	4	0	7	4.1	CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		44396220	125423	1	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/jm049720x
		CHEMBL364565	125423	1	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/jm049720x
		90666899	109445	0	None	-6	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	381	3	1	4	4.2	Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O	10.1039/C1MD00202C
		CHEMBL3220215	109445	0	None	-6	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	381	3	1	4	4.2	Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O	10.1039/C1MD00202C
		2865	4143	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		59	4143	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		60854	4143	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		CHEMBL708	4143	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		DB00246	4143	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		511482	97252	6	None	-251	5	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	325	3	1	2	4.1	Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL268799	97252	6	None	-251	5	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	325	3	1	2	4.1	Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		46917637	68332	0	None	-275	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1053	34	1	15	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		CHEMBL1916548	68332	0	None	-275	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1053	34	1	15	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		44417647	82161	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
		CHEMBL1203924	82161	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
		CHEMBL216945	82161	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
		44400519	133129	0	None	-549	5	Pig	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL370297	133129	0	None	-549	5	Pig	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		10438027	66188	0	None	-1096	6	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1016/j.bmcl.2004.05.052
		CHEMBL184383	66188	0	None	-1096	6	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1016/j.bmcl.2004.05.052
		44381147	58729	0	None	-93	4	Bovine	5.5	pKi	=	5.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL168544	58729	0	None	-93	4	Bovine	5.5	pKi	=	5.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		44340415	8578	0	None	-3	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL109472	8578	0	None	-3	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44340333	9662	0	None	-1071	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL112833	9662	0	None	-1071	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		122181330	121871	0	None	-3890	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3590081	121871	0	None	-3890	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		44372153	120164	0	None	-89	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	416	4	0	4	5.3	Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL351550	120164	0	None	-89	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	416	4	0	4	5.3	Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		71734127	91057	0	None	-6760	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		CHEMBL2397476	91057	0	None	-6760	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		10247561	98004	0	None	-3	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		CHEMBL272873	98004	0	None	-3	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		118711252	113950	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(N)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325901	113950	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(N)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		71562965	87574	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		CHEMBL2335739	87574	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		24829343	159021	0	None	-4265	9	Human	5.5	pKi	=	5.5	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		CHEMBL409662	159021	0	None	-4265	9	Human	5.5	pKi	=	5.5	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		112500031	132468	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	0	5	4.3	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697608	132468	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	0	5	4.3	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)cnc(=O)n1C	nan
		70682090	76069	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057451	76069	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70682090	76069	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057451	76069	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		72708128	92205	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425378	92205	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		11154555	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		5037	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		7671	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL2028019	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL3085826	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB06016	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		2105	3054	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	3054	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	3054	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	3054	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	3054	37	None	-537	33	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		86764215	132457	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697597	132457	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10537185	25685	0	None	-12	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135224	25685	0	None	-12	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		86767087	129416	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	318	3	1	4	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnn1C	nan
		CHEMBL3671273	129416	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	318	3	1	4	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnn1C	nan
		9948254	108269	0	None	-141	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm00402a024
		CHEMBL31973	108269	0	None	-141	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm00402a024
		15115515	108606	0	None	-47	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL320526	108606	0	None	-47	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		167715	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		969	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		CHEMBL225230	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		53317727	57943	0	None	-14	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	313	3	1	3	3.5	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		CHEMBL1672313	57943	0	None	-14	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	313	3	1	3	3.5	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		11121216	30139	0	None	-169	14	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL138989	30139	0	None	-169	14	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		167715	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
		969	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
		CHEMBL225230	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
		44395741	181581	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL476935	181581	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL558392	181581	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
		56597938	3940	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		7651	3940	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		CHEMBL2165126	3940	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		167715	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		969	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		CHEMBL225230	2876	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		44454734	97727	0	None	-912	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1	10.1016/j.bmcl.2007.12.026
		CHEMBL271513	97727	0	None	-912	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1	10.1016/j.bmcl.2007.12.026
		25130816	187711	0	None	-4786	3	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	490	8	2	5	5.8	CCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL495327	187711	0	None	-4786	3	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	490	8	2	5	5.8	CCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		45483654	198118	0	None	-14	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1	10.1021/jm901120h
		CHEMBL574569	198118	0	None	-14	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1	10.1021/jm901120h
		2779264	111342	38	None	-30	4	Bovine	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	240	3	0	2	3.3	c1ccc(CN2CCC(n3cccc3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		CHEMBL326877	111342	38	None	-30	4	Bovine	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	240	3	0	2	3.3	c1ccc(CN2CCC(n3cccc3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		42605994	17874	0	None	-16	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
		CHEMBL1259071	17874	0	None	-16	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
		11566745	74694	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
		CHEMBL1202298	74694	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
		CHEMBL203029	74694	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
		167715	2876	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		969	2876	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		CHEMBL225230	2876	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		11154555	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		5037	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		7671	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL2028019	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL3085826	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB06016	800	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		7077	66959	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		CHEMBL186720	66959	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		CHEMBL3925724	66959	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		3158	56267	27	None	-2398	20	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	56267	27	None	-2398	20	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		72708128	92205	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425378	92205	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		117774393	132458	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	307	3	1	4	3.5	Cc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c1	nan
		CHEMBL3697598	132458	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	307	3	1	4	3.5	Cc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c1	nan
		44588898	12603	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186959	12603	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL484352	12603	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		25256815	189554	0	None	-51	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	397	6	0	3	3.9	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL514382	189554	0	None	-51	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	397	6	0	3	3.9	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2009.01.067
		10833201	168611	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	373	2	0	3	4.7	CCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		CHEMBL436042	168611	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	373	2	0	3	4.7	CCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		10707972	169056	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		CHEMBL439639	169056	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		72708127	92203	0	None	-40	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425376	92203	0	None	-40	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		13091359	113539	0	None	-489	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321790	113539	0	None	-489	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		112500033	132471	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697611	132471	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		118711265	113959	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	345	2	2	3	4.4	CN1CCc2cc(-c3ccc(O)cc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325916	113959	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	345	2	2	3	4.4	CN1CCc2cc(-c3ccc(O)cc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		44415551	80309	0	None	269	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL214142	80309	0	None	269	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		2726	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		621	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		83	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		CHEMBL71	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		DB00477	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		6852376	91599	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		CHEMBL1467585	91599	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		CHEMBL24077	91599	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		CHEMBL503958	91599	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		2726	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		621	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		83	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		CHEMBL71	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		DB00477	919	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		10402378	66125	0	None	-19	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
		CHEMBL184049	66125	0	None	-19	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
		86764105	132482	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	3	1	5	3.6	Cc1cc(Sc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697623	132482	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	3	1	5	3.6	Cc1cc(Sc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		6603820	95774	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
		CHEMBL25856	95774	19	None	-4	13	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
		90140110	129438	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cn[nH]c(=O)c1C	nan
		CHEMBL3671294	129438	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cn[nH]c(=O)c1C	nan
		70690499	76071	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057453	76071	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		70690499	76071	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.12.016
		CHEMBL2057453	76071	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.12.016
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		24882561	95341	0	None	-2041	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	408	8	0	5	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		CHEMBL256637	95341	0	None	-2041	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	408	8	0	5	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		44403225	70548	0	None	-346	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	421	9	1	5	2.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL194755	70548	0	None	-346	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	421	9	1	5	2.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		44436596	91996	1	None	-436	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241631	91996	1	None	-436	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		10707972	169056	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		CHEMBL439639	169056	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		44567588	190227	0	None	-45	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	325	3	2	4	3.6	CCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL517491	190227	0	None	-45	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	325	3	2	4	3.6	CCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		90644230	111790	0	None	-1819	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287406	111790	0	None	-1819	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		10479188	202873	0	None	-316	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL62602	202873	0	None	-316	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		44319370	107047	0	None	-1	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		CHEMBL315564	107047	0	None	-1	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		44380717	120349	0	None	-138	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL353087	120349	0	None	-138	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		56926587	69010	0	None	-2290	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	329	3	0	5	2.3	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1	10.1021/jm200762g
		CHEMBL1923416	69010	0	None	-2290	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	329	3	0	5	2.3	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1	10.1021/jm200762g
		118711253	113951	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(O)c(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325903	113951	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(O)c(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		112500030	132467	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697607	132467	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		135398737	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		38	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		722	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		CHEMBL42	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		DB00363	958	93	None	-83	89	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		1353	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		3559	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		86	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		CHEMBL54	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		DB00502	1911	93	None	-74	83	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		681	1465	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	1465	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	1465	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	1465	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	1465	72	None	-23	39	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		135398745	2914	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	2914	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	2914	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	2914	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		117772904	132419	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	5	3.0	Cc1cc(Oc2nccc(C)c2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697560	132419	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	5	3.0	Cc1cc(Oc2nccc(C)c2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		90666903	109449	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	452	4	1	5	5.0	O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21	10.1039/C1MD00202C
		CHEMBL3220219	109449	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	452	4	1	5	5.0	O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21	10.1039/C1MD00202C
		155552185	174061	0	None	-660	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4544086	174061	0	None	-660	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		118709173	113421	0	None	-218	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	20	0	10	9.4	O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318846	113421	0	None	-218	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	20	0	10	9.4	O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		72545240	93129	0	None	-229	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	469	12	0	8	3.4	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443007	93129	0	None	-229	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	469	12	0	8	3.4	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		52937777	61171	0	None	-6165	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	464	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1	10.1021/jm101639t
		CHEMBL1765630	61171	0	None	-6165	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	464	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1	10.1021/jm101639t
		57395340	69300	0	None	-407	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		CHEMBL1928124	69300	0	None	-407	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		71734029	91055	0	None	-10964	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		CHEMBL2397392	91055	0	None	-10964	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		14198593	198674	1	None	4	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		CHEMBL57988	198674	1	None	4	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		10064053	95907	0	None	-1995	6	Rat	5.4	pKi	=	5.4	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm960189i
		CHEMBL25924	95907	0	None	-1995	6	Rat	5.4	pKi	=	5.4	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm960189i
		10546334	65246	0	None	-2187	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	358	4	2	4	4.0	c1ccc2c(N3CCN(CCc4ccc5c(c4)NCN5)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		CHEMBL182721	65246	0	None	-2187	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	358	4	2	4	4.0	c1ccc2c(N3CCN(CCc4ccc5c(c4)NCN5)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		57580939	92201	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425374	92201	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		154726529	176445	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4467486	176445	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596338	176445	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		15711870	12956	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1189332	12956	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL538520	12956	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		154704418	176587	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4546749	176587	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4597533	176587	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
		44567688	192275	0	None	-8	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	295	2	1	3	3.5	CCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		CHEMBL520573	192275	0	None	-8	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	295	2	1	3	3.5	CCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		42625293	56249	0	None	-912	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		CHEMBL1627319	56249	0	None	-912	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		3036864	202754	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	202754	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	202754	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	202754	19	None	-26	28	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		133	2496	52	None	-30	42	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	2496	52	None	-30	42	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	2496	52	None	-30	42	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	2496	52	None	-30	42	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	2496	52	None	-30	42	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		24847750	183203	9	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/np50094a001
		CHEMBL479587	183203	9	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/np50094a001
		5281878	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		5281881	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		948	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		968	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		CHEMBL42055	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		CHEMBL54661	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		DB00875	1660	35	None	-11	17	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		11777127	25810	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL135318	25810	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		118711256	113954	0	None	-37	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325906	113954	0	None	-37	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		15115516	9768	0	None	-1148	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL113527	9768	0	None	-1148	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		53317511	57938	0	None	-107	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	329	3	2	4	3.2	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		CHEMBL1672308	57938	0	None	-107	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	329	3	2	4	3.2	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		44380816	120351	0	None	-77	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL353090	120351	0	None	-77	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44448059	94820	0	None	5	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL253530	94820	0	None	5	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		137655451	158853	0	None	-288	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4094869	158853	0	None	-288	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		3033769	3281	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		3299	3281	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		94	3281	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		CHEMBL8809	3281	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		DB12518	3281	61	None	-10232	19	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		10544858	170028	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
		CHEMBL444269	170028	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
		CHEMBL542181	170028	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
		228	445	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		33	445	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		6005	445	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		CHEMBL53	445	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		DB00714	445	28	None	-35	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		16573	177619	34	None	-18	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL464099	177619	34	None	-18	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		44320267	206212	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL86576	206212	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44278297	99076	0	None	-2511	3	Rat	4.4	pKi	=	4.4	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	382	4	0	2	5.0	O=C(c1cccc(CN2CCC(c3ccc(Cl)cc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		CHEMBL280534	99076	0	None	-2511	3	Rat	4.4	pKi	=	4.4	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	382	4	0	2	5.0	O=C(c1cccc(CN2CCC(c3ccc(Cl)cc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		130442557	167073	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4289538	167073	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		71110287	146325	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3921127	146325	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		235224	128155	29	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		CHEMBL36654	128155	29	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		72708127	92203	0	None	-40	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425376	92203	0	None	-40	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		44396235	168537	1	None	-23	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/jm049720x
		CHEMBL435505	168537	1	None	-23	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/jm049720x
		72699718	115194	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	355	3	1	4	4.5	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CCC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344465	115194	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	355	3	1	4	4.5	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CCC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		135458464	81128	0	None	-1122	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	486	3	1	5	6.2	FC(F)(F)Oc1cccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL215669	81128	0	None	-1122	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	486	3	1	5	6.2	FC(F)(F)Oc1cccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c1	10.1016/j.bmcl.2006.06.034
		46231783	200533	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	357	1	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C(=O)O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598915	200533	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	357	1	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C(=O)O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		130442473	167337	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4294397	167337	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
		86764318	132460	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	349	4	1	5	3.1	Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697600	132460	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	349	4	1	5	3.1	Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O	nan
		117773358	132417	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	3	1	5	4.2	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697558	132417	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	3	1	5	4.2	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		23625925	93571	0	None	-18	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	368	3	1	5	3.3	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21	10.1039/C1MD00202C
		CHEMBL246484	93571	0	None	-18	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	368	3	1	5	3.3	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21	10.1039/C1MD00202C
		10436653	32792	1	None	-562	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	521	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1	10.1021/jm025558r
		CHEMBL141419	32792	1	None	-562	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	521	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1	10.1021/jm025558r
		147230103	180153	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2020.127563
		CHEMBL4748915	180153	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2020.127563
		53327908	61609	0	None	-3162	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	470	8	0	5	4.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771112	61609	0	None	-3162	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	470	8	0	5	4.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		3082625	194728	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL53510	194728	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		53327665	66480	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
		CHEMBL1852240	66480	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
		CHEMBL3216759	66480	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
		128434	195706	8	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	227	1	3	3	2.2	NCC1c2ccccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		CHEMBL55693	195706	8	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	227	1	3	3	2.2	NCC1c2ccccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		10386748	104752	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		CHEMBL310734	104752	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		10386748	104752	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL310734	104752	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		53363199	63852	0	None	-457	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	481	12	0	9	3.2	CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803051	63852	0	None	-457	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	481	12	0	9	3.2	CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		25139477	184245	0	None	-870	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	486	10	1	2	6.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		CHEMBL483593	184245	0	None	-870	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	486	10	1	2	6.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		49782603	17489	0	None	-151	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	385	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1257811	17489	0	None	-151	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	385	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		137634397	156105	0	None	-11748	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		CHEMBL4063145	156105	0	None	-11748	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		10802235	13259	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL1191487	13259	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL542593	13259	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
		72545238	93127	0	None	-7413	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	425	9	0	7	3.3	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443005	93127	0	None	-7413	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	425	9	0	7	3.3	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		112500028	132465	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697605	132465	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		56971032	69249	0	None	-114	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccccn1	10.1016/j.ejmech.2011.11.023
		CHEMBL1927094	69249	0	None	-114	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccccn1	10.1016/j.ejmech.2011.11.023
		3082625	194728	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
		CHEMBL53510	194728	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
		3082625	194728	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL53510	194728	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		44582675	189701	0	None	-64	15	Human	5.4	pKi	=	5.4	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL515472	189701	0	None	-64	15	Human	5.4	pKi	=	5.4	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		10786190	114732	0	None	-50	3	Rat	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	383	2	0	4	3.7	CN1CCc2cccc3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm960189i
		CHEMBL333836	114732	0	None	-50	3	Rat	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	383	2	0	4	3.7	CN1CCc2cccc3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm960189i
		44406003	133158	0	None	4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		CHEMBL370364	133158	0	None	4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		448537	160250	89	None	-28	25	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	160250	89	None	-28	25	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		10813037	47157	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	439	3	1	3	4.7	COc1ccc(Br)c(CC2c3c(O)ccc(Br)c3CCN2C)c1	10.1021/jm991034o
		CHEMBL154301	47157	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	439	3	1	3	4.7	COc1ccc(Br)c(CC2c3c(O)ccc(Br)c3CCN2C)c1	10.1021/jm991034o
		90644059	112030	0	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289643	112030	0	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		10781204	120049	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	309	3	0	3	4.4	CCCN1CCc2cccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		CHEMBL350457	120049	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	309	3	0	3	4.4	CCCN1CCc2cccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		76321556	106377	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115578	106377	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139302	106377	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		76325150	106422	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3115575	106422	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3139554	106422	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		44415658	141572	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	527	3	1	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3sccc3-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL384916	141572	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	527	3	1	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3sccc3-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		25110706	12604	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL1186960	12604	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL484356	12604	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
		86767096	129428	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C#N	nan
		CHEMBL3671285	129428	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C#N	nan
		2337	3256	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		50	3256	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		5002	3256	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		CHEMBL716	3256	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		DB01224	3256	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		44276572	96648	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL26365	96648	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		53364225	63845	0	None	-117	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	932	25	0	18	5.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803027	63845	0	None	-117	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	932	25	0	18	5.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		30133	67638	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
		CHEMBL190519	67638	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
		CHEMBL541862	67638	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
		10667966	57160	0	None	-2	4	Bovine	5.4	pKi	=	5.4	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	387	5	0	1	6.1	CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1	10.1021/jm991098z
		CHEMBL164736	57160	0	None	-2	4	Bovine	5.4	pKi	=	5.4	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	387	5	0	1	6.1	CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1	10.1021/jm991098z
		44412182	77266	0	None	-3890	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL208018	77266	0	None	-3890	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2006.02.075
		122177642	121210	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		CHEMBL3577343	121210	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		24823921	97896	0	None	-21	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		CHEMBL272395	97896	0	None	-21	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		9995378	5473	0	None	-301	4	Bovine	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		CHEMBL107529	5473	0	None	-301	4	Bovine	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		10359539	59054	10	None	-125	4	Bovine	4.4	pKi	=	4.4	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL169459	59054	10	None	-125	4	Bovine	4.4	pKi	=	4.4	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		91899759	129445	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	342	3	1	6	3.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1C#N	nan
		CHEMBL3671300	129445	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	342	3	1	6	3.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1C#N	nan
		57580939	92201	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425374	92201	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		1242	3613	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
		935	3613	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
		CHEMBL286080	3613	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
		1242	3613	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
		935	3613	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
		CHEMBL286080	3613	27	None	-5	18	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
		10333837	113534	0	None	-51	3	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	0	2	3.8	COc1c(C)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL332178	113534	0	None	-51	3	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	0	2	3.8	COc1c(C)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		25130157	103307	0	None	-5495	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
		CHEMBL3084515	103307	0	None	-5495	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
		135409492	169170	50	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
		CHEMBL440512	169170	50	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
		15467370	102318	0	None	-3630	4	Bovine	4.4	pKi	=	4.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL303538	102318	0	None	-3630	4	Bovine	4.4	pKi	=	4.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		76321556	106377	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115578	106377	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139302	106377	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		151086	91978	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		CHEMBL2414991	91978	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		3802	203023	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm960084f
		CHEMBL63329	203023	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm960084f
		3802	203023	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm00067a009
		CHEMBL63329	203023	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm00067a009
		4302960	101061	63	None	-1258	6	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	485	10	1	5	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL294747	101061	63	None	-1258	6	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	485	10	1	5	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		10247701	85883	0	None	-2398	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	4	1	3	4.1	c1ccc2c(N3CCN(CCc4ccc5[nH]cnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		CHEMBL2298806	85883	0	None	-2398	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	4	1	3	4.1	c1ccc2c(N3CCN(CCc4ccc5[nH]cnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		162657175	180833	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	331	2	1	3	5.1	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4756987	180833	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	331	2	1	3	5.1	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		16007117	80036	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212912	80036	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415518	80078	0	None	45	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213084	80078	0	None	45	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415724	80258	0	None	97	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	547	2	1	5	6.4	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cc(Cl)cc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213881	80258	0	None	97	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	547	2	1	5	6.4	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cc(Cl)cc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11637457	73087	1	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
		CHEMBL201093	73087	1	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
		71562964	87575	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335740	87575	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		37459	746	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
		62	746	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
		CHEMBL8514	746	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
		16007117	80036	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212912	80036	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		15111049	13955	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL1196674	13955	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL557799	13955	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
		74223771	129420	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		CHEMBL3671277	129420	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		86764214	132456	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	4	1	5	4.6	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)(F)F	nan
		CHEMBL3697596	132456	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	4	1	5	4.6	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)(F)F	nan
		71109897	87513	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL2334893	87513	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	10.1016/j.bmc.2012.12.016
		134145434	149409	0	None	173	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	449	5	2	6	3.6	COCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3945691	149409	0	None	173	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	449	5	2	6	3.6	COCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		45379369	7522	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
		CHEMBL1087300	7522	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
		71109897	87513	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		CHEMBL2334893	87513	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		37459	746	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
		62	746	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
		CHEMBL8514	746	13	None	-10	25	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
		10518837	100473	0	None	33	2	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL290842	100473	0	None	33	2	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
		46231924	200578	0	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		CHEMBL599134	200578	0	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		5249956	73395	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL201525	73395	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
		5249956	73395	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
		CHEMBL201525	73395	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
		440229	87511	53	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2334891	87511	53	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		5249956	73395	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
		CHEMBL201525	73395	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
		74223826	129437	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671293	129437	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		228	445	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		33	445	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		6005	445	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL53	445	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		DB00714	445	28	None	-35	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		86767083	129411	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	4	5.3	[C-]#[N+]c1c[nH]c2ccnc(Oc3ccc(-c4c(C)ncnc4C)c(C)c3)c12	nan
		CHEMBL3671268	129411	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	4	5.3	[C-]#[N+]c1c[nH]c2ccnc(Oc3ccc(-c4c(C)ncnc4C)c(C)c3)c12	nan
		44323851	206974	0	None	3	4	Rat	8.3	pKi	=	8.3	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL91310	206974	0	None	3	4	Rat	8.3	pKi	=	8.3	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		46231770	201310	0	None	213	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NS(C)(=O)=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL604135	201310	0	None	213	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NS(C)(=O)=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		74223772	129422	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671279	129422	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		25110705	12740	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL1187785	12740	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL520821	12740	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
		146266	100698	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL292418	100698	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL540857	100698	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
		11324141	63858	0	None	1	3	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	303	1	0	5	3.2	CN1CCN(C2=Cn3cccc3Sc3sccc32)CC1	10.1021/jm049629t
		CHEMBL180319	63858	0	None	1	3	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	303	1	0	5	3.2	CN1CCN(C2=Cn3cccc3Sc3sccc32)CC1	10.1021/jm049629t
		44386836	63022	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	342	3	0	4	3.6	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		CHEMBL178797	63022	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	342	3	0	4	3.6	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		1153	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		12668023	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		30026874	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		30026875	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		3341	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		6603851	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		933	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		939	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		985	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		CHEMBL1160786	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		CHEMBL1161520	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		CHEMBL588	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		DB00800	1628	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		122205438	137400	0	None	-26	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
		CHEMBL3753266	137400	0	None	-26	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
		71722299	102480	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397383	102480	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040217	102480	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		127031398	138807	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	411	8	1	5	5.0	CCCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3781035	138807	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	411	8	1	5	5.0	CCCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		14198584	198269	0	None	12	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL57579	198269	0	None	12	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1016/j.bmc.2009.05.079
		86763998	132474	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697614	132474	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		74223832	129451	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		CHEMBL3671306	129451	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		53364083	63854	0	None	-28	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	658	21	0	11	6.2	CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803053	63854	0	None	-28	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	658	21	0	11	6.2	CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		44339992	109184	0	None	-501	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL321492	109184	0	None	-501	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		49782841	17652	0	None	-2511	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	523	7	1	4	6.1	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1	10.1021/jm100899z
		CHEMBL1258382	17652	0	None	-2511	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	523	7	1	4	6.1	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1	10.1021/jm100899z
		137633454	156591	0	None	-1230	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	645	16	3	10	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		CHEMBL4068702	156591	0	None	-1230	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	645	16	3	10	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		71454405	78425	0	None	-30	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111528	78425	0	None	-30	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		44319102	206141	0	None	-16	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL86060	206141	0	None	-16	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		11631892	78111	0	None	-30902	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	4	0	6	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1	10.1021/jm060166w
		CHEMBL210283	78111	0	None	-30902	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	4	0	6	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1	10.1021/jm060166w
		151086	91978	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		CHEMBL2414991	91978	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		4011	82408	49	None	-64	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
		CHEMBL21731	82408	49	None	-64	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
		118717796	115192	0	None	-14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	4	1	4	4.7	CCC(C)Cc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344462	115192	0	None	-14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	4	1	4	4.7	CCC(C)Cc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		11349297	85880	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	372	5	2	4	2.7	O=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		CHEMBL2298800	85880	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	372	5	2	4	2.7	O=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		72708060	92197	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425370	92197	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		44320123	107083	0	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL315849	107083	0	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		72708060	92197	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425370	92197	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		70692801	76563	0	None	-5	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062850	76563	0	None	-5	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		118709751	113541	0	None	-3162	10	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		CHEMBL3321792	113541	0	None	-3162	10	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		156020547	178158	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	387	4	1	3	4.3	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4649012	178158	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	387	4	1	3	4.3	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		74223830	129450	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671305	129450	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		9909648	205573	3	None	-134	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm960084f
		CHEMBL81330	205573	3	None	-134	12	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm960084f
		71463207	84074	0	None	-169	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	357	4	0	4	4.0	COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207636	84074	0	None	-169	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	357	4	0	4	4.0	COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		137640203	156962	0	None	-54	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
		CHEMBL4072821	156962	0	None	-54	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
		10917920	111446	0	None	-5128	9	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	487	6	1	6	3.8	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL327527	111446	0	None	-5128	9	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	487	6	1	6	3.8	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		45482151	198009	0	None	-831	4	Pig	5.4	pKi	=	5.4	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	451	8	1	9	1.7	COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1	10.1016/j.bmc.2009.06.041
		CHEMBL573791	198009	0	None	-831	4	Pig	5.4	pKi	=	5.4	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	451	8	1	9	1.7	COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1	10.1016/j.bmc.2009.06.041
		44403220	71926	0	None	-169	5	Pig	5.4	pKi	=	5.4	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL197214	71926	0	None	-169	5	Pig	5.4	pKi	=	5.4	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1	10.1016/j.bmcl.2005.07.037
		44380921	58329	0	None	-11	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL168274	58329	0	None	-11	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		9977532	111191	1	None	-9999	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL326454	111191	1	None	-9999	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		71457844	84076	0	None	-2137	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207638	84076	0	None	-2137	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		44381117	57831	0	None	-120	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL167032	57831	0	None	-120	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		9909648	205573	3	None	-134	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.7b00151
		CHEMBL81330	205573	3	None	-134	12	Human	6.4	pKi	=	6.4	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.7b00151
		161379	187215	8	None	-79	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		CHEMBL492418	187215	8	None	-79	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		681	1465	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		940	1465	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		947	1465	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		CHEMBL59	1465	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		DB00988	1465	72	None	-97	39	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		10085358	110219	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		CHEMBL323771	110219	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		76328713	106404	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3115576	106404	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3139455	106404	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		1816	2540	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		4205	2540	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		7241	2540	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		CHEMBL654	2540	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		DB00370	2540	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		21119297	92200	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425373	92200	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		44299940	100967	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		CHEMBL294186	100967	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		44415535	80150	0	None	42	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213388	80150	0	None	42	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		24900557	198387	0	None	-17	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	409	4	1	7	3.4	CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		CHEMBL576756	198387	0	None	-17	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	409	4	1	7	3.4	CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		44393403	65078	0	None	-416	6	Pig	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1016/j.bmcl.2004.05.052
		CHEMBL182379	65078	0	None	-416	6	Pig	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1016/j.bmcl.2004.05.052
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		135398737	958	93	None	-37	89	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		38	958	93	None	-37	89	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		722	958	93	None	-37	89	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		CHEMBL42	958	93	None	-37	89	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		DB00363	958	93	None	-37	89	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		57393628	69313	0	None	-1230	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	5.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928137	69313	0	None	-1230	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	5.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		135398737	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		38	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		722	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		CHEMBL42	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		DB00363	958	93	None	-204	89	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		44339984	167797	0	None	-186	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL430522	167797	0	None	-186	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		53362841	63961	0	None	-16	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		CHEMBL1806870	63961	0	None	-16	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		53328719	66472	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852163	66472	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL3216980	66472	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		70690651	76561	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		CHEMBL2062848	76561	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		44588932	12608	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186975	12608	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL485041	12608	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		68663	27282	23	None	-6	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		CHEMBL136711	27282	23	None	-6	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		2337	3256	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		50	3256	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		5002	3256	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		CHEMBL716	3256	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		DB01224	3256	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		1016	3747	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	3747	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	3747	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	3747	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	3747	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	3747	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		44582140	182498	0	None	-10	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	7	0	4	3.3	COc1cccc(N2CCN(CCCCN3CCc4ccccc4C3=O)CC2)c1	10.1016/j.bmcl.2009.01.067
		CHEMBL478688	182498	0	None	-10	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	7	0	4	3.3	COc1cccc(N2CCN(CCCCN3CCc4ccccc4C3=O)CC2)c1	10.1016/j.bmcl.2009.01.067
		44327167	9378	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL111393	9378	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL544319	9378	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
		10516949	47919	0	None	2	2	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1cc2c3c(c1)Oc1ccccc1CC3N(C)CC2	10.1021/jm991034o
		CHEMBL154948	47919	0	None	2	2	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1cc2c3c(c1)Oc1ccccc1CC3N(C)CC2	10.1021/jm991034o
		117774121	132447	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	384	4	1	6	3.0	Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697588	132447	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	384	4	1	6	3.0	Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O	nan
		9945168	123665	0	None	-41	3	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	325	2	0	5	3.0	CN1CCN(C2=Cn3c(C=O)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL362060	123665	0	None	-41	3	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	325	2	0	5	3.0	CN1CCN(C2=Cn3c(C=O)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		76325150	106422	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3115575	106422	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3139554	106422	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		135398737	958	93	None	-83	89	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		38	958	93	None	-83	89	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		722	958	93	None	-83	89	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		CHEMBL42	958	93	None	-83	89	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		DB00363	958	93	None	-83	89	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		124618	198380	7	None	134	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	243	1	4	4	1.9	NCC1c2cc(O)ccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		CHEMBL57672	198380	7	None	134	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	243	1	4	4	1.9	NCC1c2cc(O)ccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		86764319	132464	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697604	132464	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		127047221	139930	0	None	-1	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		CHEMBL3799593	139930	0	None	-1	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		127046950	140045	0	None	-23	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800303	140045	0	None	-23	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		25071385	159157	0	None	-208	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4098236	159157	0	None	-208	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		681	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		940	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		947	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		CHEMBL59	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		DB00988	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		681	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		940	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		947	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		CHEMBL59	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		DB00988	1465	72	None	-23	39	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		10333842	98431	1	None	-31	8	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		CHEMBL27559	98431	1	None	-31	8	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		44448070	94893	0	None	3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL254147	94893	0	None	3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		25071691	111787	0	None	-2818	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287403	111787	0	None	-2818	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		72545239	93128	0	None	-426	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	499	14	0	9	3.0	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443006	93128	0	None	-426	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	499	14	0	9	3.0	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		21119297	92200	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425373	92200	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		25186021	188024	0	None	-1318	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	10.1021/jm800689g
		CHEMBL497574	188024	0	None	-1318	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	10.1021/jm800689g
		10333842	98431	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		CHEMBL27559	98431	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		10333842	98431	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		CHEMBL27559	98431	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		1530	2182	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	2182	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	2182	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	2182	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	2182	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		76328713	106404	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3115576	106404	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3139455	106404	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		71722291	102460	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397385	102460	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040059	102460	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		11712530	187890	0	None	-41686	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm800689g
		CHEMBL496531	187890	0	None	-41686	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm800689g
		135398737	958	93	None	-44	89	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		38	958	93	None	-44	89	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		722	958	93	None	-44	89	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		CHEMBL42	958	93	None	-44	89	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		DB00363	958	93	None	-44	89	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		44415849	141413	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	509	3	1	6	5.1	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL384069	141413	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	509	3	1	6	5.1	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		86764104	132481	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697622	132481	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		74223775	129431	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	316	3	1	4	4.4	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		CHEMBL3671288	129431	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	316	3	1	4	4.4	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		681	1465	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		940	1465	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		947	1465	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		CHEMBL59	1465	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		DB00988	1465	72	None	-23	39	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		137657115	159755	0	None	-173	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4105030	159755	0	None	-173	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		10831251	163173	0	None	4	2	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL41809	163173	0	None	4	2	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		44340084	9088	0	None	-2238	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL109912	9088	0	None	-2238	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		25131137	187547	0	None	-190	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	558	9	2	5	7.4	Nc1nc2c(s1)C[C@@H](N(CCC1CCCCC1)CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		CHEMBL494509	187547	0	None	-190	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	558	9	2	5	7.4	Nc1nc2c(s1)C[C@@H](N(CCC1CCCCC1)CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		681	1465	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		940	1465	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		947	1465	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		CHEMBL59	1465	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		DB00988	1465	72	None	-97	39	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		70696888	76573	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062860	76573	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		44329039	208137	0	None	-56	3	Bovine	4.4	pKi	=	4.4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL98072	208137	0	None	-56	3	Bovine	4.4	pKi	=	4.4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		14198585	100801	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	100801	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		14198585	100801	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00118a012
		CHEMBL293158	100801	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00118a012
		44320076	206426	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87910	206426	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		11282465	193118	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL522746	193118	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		11406615	85903	0	None	-162	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	388	5	2	4	4.1	S=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		CHEMBL2298832	85903	0	None	-162	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	388	5	2	4	4.1	S=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		14198585	100801	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	100801	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		14198585	100801	1	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00129a006
		CHEMBL293158	100801	1	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00129a006
		44415759	141688	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	3	1	5	6.5	CC(C)(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL385590	141688	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	3	1	5	6.5	CC(C)(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		681	1465	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		940	1465	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		947	1465	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		CHEMBL59	1465	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		DB00988	1465	72	None	-154	39	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		44276551	97376	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL26965	97376	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		10333842	98431	1	None	-31	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmc.2008.08.056
		CHEMBL27559	98431	1	None	-31	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmc.2008.08.056
		10588327	13781	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL1195441	13781	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL554571	13781	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
		72699903	115198	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)Cl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344469	115198	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)Cl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		122197088	132415	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	362	3	1	5	3.4	[C-]#[N+]c1c(C)ccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		CHEMBL3697556	132415	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	362	3	1	5	3.4	[C-]#[N+]c1c(C)ccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		71563082	87281	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2331599	87281	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		9908125	119344	0	None	-20	4	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1	10.1021/jm0009989
		CHEMBL344270	119344	0	None	-20	4	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1	10.1021/jm0009989
		11016418	106122	0	None	-7244	8	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	488	6	0	7	4.2	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL313424	106122	0	None	-7244	8	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	488	6	0	7	4.2	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		71456046	84075	0	None	-2951	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207637	84075	0	None	-2951	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		127045853	139793	0	None	-17782	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3798748	139793	0	None	-17782	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		137655795	158582	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4091933	158582	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		12050201	202874	0	None	-31	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	7	1	5	5.3	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL62624	202874	0	None	-31	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	7	1	5	5.3	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		44319361	205720	0	None	-7	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL82527	205720	0	None	-7	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		44264629	97366	0	None	-316	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL269576	97366	0	None	-316	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		72545011	93126	0	None	-3162	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	411	8	0	7	2.9	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443004	93126	0	None	-3162	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	411	8	0	7	2.9	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		42606339	17931	0	None	-97	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
		CHEMBL1259241	17931	0	None	-97	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
		71734126	91054	0	None	-4466	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		CHEMBL2397391	91054	0	None	-4466	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		2812	4779	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	4779	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		127027737	137987	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	342	6	1	4	2.2	O=C(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3764420	137987	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	342	6	1	4	2.2	O=C(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		44399174	68012	0	None	-870	4	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatumInhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatum	ChEMBL	449	6	0	5	3.0	O=C1C2C3C=CC(C3)C2C(=O)N1OCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm050246k
		CHEMBL191226	68012	0	None	-870	4	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatumInhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatum	ChEMBL	449	6	0	5	3.0	O=C1C2C3C=CC(C3)C2C(=O)N1OCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm050246k
		44282127	116569	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL1743804	116569	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL33644	116569	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		3083157	63036	2	None	-229	2	Rat	6.3	pKi	=	6.3	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	277	2	1	2	3.7	C=CCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		CHEMBL1788212	63036	2	None	-229	2	Rat	6.3	pKi	=	6.3	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	277	2	1	2	3.7	C=CCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		15711852	13339	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192193	13339	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL543389	13339	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		176	398	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	398	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	398	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	398	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	398	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		145968810	165038	0	None	-120	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		CHEMBL4226226	165038	0	None	-120	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		15937731	117490	6	None	5	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	211	0	1	2	2.1	CN1CCc2cc(O)c(Cl)cc2CC1	10.1016/S0960-894X(00)80155-9
		CHEMBL340006	117490	6	None	5	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	211	0	1	2	2.1	CN1CCc2cc(O)c(Cl)cc2CC1	10.1016/S0960-894X(00)80155-9
		24766199	97524	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm701045j
		CHEMBL270426	97524	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm701045j
		24766199	97524	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm9015763
		CHEMBL270426	97524	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm9015763
		44301054	196148	0	None	-218	6	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		CHEMBL56118	196148	0	None	-218	6	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		25139481	184840	0	None	-32	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	392	10	1	2	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1	10.1021/jm800895v
		CHEMBL485227	184840	0	None	-32	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	392	10	1	2	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1	10.1021/jm800895v
		25186569	176982	0	None	-45708	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		CHEMBL462508	176982	0	None	-45708	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		122177643	121211	0	None	-2884	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	632	20	3	9	5.1	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1	10.1021/jm501889t
		CHEMBL3577344	121211	0	None	-2884	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	632	20	3	9	5.1	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1	10.1021/jm501889t
		3198	205513	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	205513	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	205513	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		10803661	110922	0	None	-2	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	1	1	3	3.3	CC(=O)c1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL326159	110922	0	None	-2	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	1	1	3	3.3	CC(=O)c1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		25141534	56235	0	None	-2238	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		CHEMBL1627305	56235	0	None	-2238	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		76314268	106434	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115577	106434	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139633	106434	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		1353	1911	93	None	-74	83	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		3559	1911	93	None	-74	83	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		86	1911	93	None	-74	83	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		CHEMBL54	1911	93	None	-74	83	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		DB00502	1911	93	None	-74	83	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		10042602	66290	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1016/j.bmcl.2004.06.005
		CHEMBL184770	66290	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1016/j.bmcl.2004.06.005
		3106	48520	16	None	-87	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		CHEMBL15564	48520	16	None	-87	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		10042602	66290	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1007/s00044-012-0055-5
		CHEMBL184770	66290	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1007/s00044-012-0055-5
		10683943	114382	0	None	-81	3	Rat	5.3	pKi	=	5.3	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	277	1	0	2	3.6	CC(=O)c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL333134	114382	0	None	-81	3	Rat	5.3	pKi	=	5.3	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	277	1	0	2	3.6	CC(=O)c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		135398745	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		47	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		CHEMBL715	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		DB00334	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		1353	1911	93	None	-74	83	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		3559	1911	93	None	-74	83	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		86	1911	93	None	-74	83	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		CHEMBL54	1911	93	None	-74	83	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		DB00502	1911	93	None	-74	83	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		46869265	16257	0	None	-4	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2012.08.058
		CHEMBL1224527	16257	0	None	-4	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2012.08.058
		44415839	79897	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212402	79897	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415345	81314	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		CHEMBL215885	81314	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		44415517	80077	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213083	80077	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415345	81314	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		CHEMBL215885	81314	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		11186086	63373	0	None	-12	4	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	313	1	0	3	3.2	CN1CCN(C2=Cc3cc(Cl)ccc3Cn3cccc32)CC1	10.1021/jm049629t
		CHEMBL179557	63373	0	None	-12	4	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	313	1	0	3	3.2	CN1CCN(C2=Cc3cc(Cl)ccc3Cn3cccc32)CC1	10.1021/jm049629t
		45482153	198038	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	502	9	1	7	3.9	COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		CHEMBL574030	198038	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	502	9	1	7	3.9	COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		137644833	158139	0	None	-87	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4087187	158139	0	None	-87	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		44436606	91997	0	None	-1445	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241641	91997	0	None	-1445	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		44339992	109184	0	None	-501	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL321492	109184	0	None	-501	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		9977532	111191	1	None	-9999	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL326454	111191	1	None	-9999	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		71734129	91061	0	None	-10964	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		CHEMBL2397480	91061	0	None	-10964	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		137654675	158634	0	None	-1230	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		CHEMBL4092441	158634	0	None	-1230	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		11652518	165932	0	None	-16	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL425064	165932	0	None	-16	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1	10.1021/jm060166w
		44329090	208026	0	None	-26	3	Bovine	4.3	pKi	=	4.3	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97436	208026	0	None	-26	3	Bovine	4.3	pKi	=	4.3	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		134	2514	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	2514	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	2514	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	2514	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	2514	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		14787976	196980	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL56666	196980	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		44320303	163967	0	None	2	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL420788	163967	0	None	2	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		11358377	202339	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
		CHEMBL610449	202339	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
		44415646	139778	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	635	4	1	7	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OC(F)(F)O4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL379862	139778	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	635	4	1	7	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OC(F)(F)O4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		10264969	48295	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		CHEMBL155352	48295	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		15696487	163799	1	None	9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL420604	163799	1	None	9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		15654858	102300	0	None	2	2	Rat	4.3	pKi	=	4.3	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3cccnc3N(C=O)c3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL303435	102300	0	None	2	2	Rat	4.3	pKi	=	4.3	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3cccnc3N(C=O)c3ccccc32)CC1	10.1021/jm00067a009
		44415807	141636	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccccc1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL385295	141636	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccccc1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		15111052	12775	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1187965	12775	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL534678	12775	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		156017805	177826	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	343	4	1	3	4.2	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4643886	177826	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	343	4	1	3	4.2	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1	10.1016/j.bmcl.2020.127305
		21171	186976	33	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		CHEMBL490533	186976	33	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		46893146	61607	0	None	-3981	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771110	61607	0	None	-3981	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53363202	63856	0	None	-26	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	961	28	0	15	8.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803055	63856	0	None	-26	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	961	28	0	15	8.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		122191605	123720	0	None	-23	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	426	7	2	3	4.2	Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1	10.1021/acsmedchemlett.5b00131
		CHEMBL3622097	123720	0	None	-23	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	426	7	2	3	4.2	Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1	10.1021/acsmedchemlett.5b00131
		44319370	107047	0	None	-1	4	Bovine	6.3	pKi	=	6.3	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		CHEMBL315564	107047	0	None	-1	4	Bovine	6.3	pKi	=	6.3	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		10264969	48295	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		CHEMBL155352	48295	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		137634397	156105	0	None	-11748	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		CHEMBL4063145	156105	0	None	-11748	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		24824062	155712	0	None	-79	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1	10.1021/jm701375u
		CHEMBL405260	155712	0	None	-79	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1	10.1021/jm701375u
		44372312	53785	0	None	-43	3	Bovine	5.3	pKi	=	5.3	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		CHEMBL160396	53785	0	None	-43	3	Bovine	5.3	pKi	=	5.3	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		11492	37505	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
		59111271	37505	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
		CHEMBL145584	37505	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
		42606573	17846	0	None	-81	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
		CHEMBL1258999	17846	0	None	-81	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
		136043859	138905	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	430	2	1	4	5.9	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL378301	138905	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	430	2	1	4	5.9	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		10618131	28503	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	354	6	2	4	3.4	CN(C)CCCCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL137583	28503	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	354	6	2	4	3.4	CN(C)CCCCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		10518820	110400	0	None	-31	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	307	2	0	3	3.7	COc1c(C(C)=O)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL324372	110400	0	None	-31	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	307	2	0	3	3.7	COc1c(C(C)=O)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		12049521	203191	0	None	-13	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	427	5	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64288	203191	0	None	-13	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	427	5	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		117773325	132421	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	5	2.7	Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697562	132421	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	5	2.7	Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44582517	181639	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.3	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477446	181639	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.3	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		154726792	176584	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4475406	176584	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597530	176584	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		9841398	99519	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		CHEMBL28338	99519	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		9841398	99519	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL28338	99519	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		44276552	99880	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL285924	99880	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		1353	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		3559	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		86	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		CHEMBL54	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		DB00502	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		44415822	168842	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(F)cc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL437917	168842	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(F)cc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		10409038	85242	0	None	-41	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL225853	85242	0	None	-41	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		118709176	113424	0	None	-34	4	Pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1106	29	0	14	11.8	O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318849	113424	0	None	-34	4	Pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1106	29	0	14	11.8	O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		9952858	7554	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		CHEMBL108764	7554	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		9952858	7554	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL108764	7554	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		167715	2876	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		969	2876	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL225230	2876	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		11504230	78217	0	None	-870	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		CHEMBL210567	78217	0	None	-870	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		10830557	31301	0	None	-4	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1	10.1021/jm0009989
		CHEMBL140165	31301	0	None	-4	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1	10.1021/jm0009989
		46905072	10177	0	None	-28	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL1159663	10177	0	None	-28	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		25131138	187549	0	None	-9549	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	480	8	2	6	5.4	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3o2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL494511	187549	0	None	-9549	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	480	8	2	6	5.4	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3o2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		49782602	17169	0	None	-162	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	583	6	1	3	7.4	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1256169	17169	0	None	-162	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	583	6	1	3	7.4	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		57390117	69299	0	None	-346	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.2	CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		CHEMBL1928123	69299	0	None	-346	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.2	CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		70690653	76574	0	None	-32	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062861	76574	0	None	-32	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		45481890	199016	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	9	2	9	4.4	COc1ccccc1N1CCN(CCCn2cc(CN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL585742	199016	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	9	2	9	4.4	COc1ccccc1N1CCN(CCCn2cc(CN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		228	445	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		33	445	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		6005	445	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		CHEMBL53	445	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		DB00714	445	28	None	-35	24	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		15225750	141385	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	383	1	1	5	3.2	CC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL383869	141385	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	383	1	1	5	3.2	CC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		57391216	70168	0	None	-23	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940416	70168	0	None	-23	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		44304603	203138	0	None	-43	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL64139	203138	0	None	-43	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		42625211	56239	0	None	-81	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
		CHEMBL1627309	56239	0	None	-81	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
		14138285	145155	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		CHEMBL3912178	145155	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		5016	109169	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL32145	109169	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL544114	109169	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		74223772	129422	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671279	129422	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		86767101	129436	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	393	4	1	5	4.4	Cc1ncnc(N2CC(F)C2)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671292	129436	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	393	4	1	5	4.4	Cc1ncnc(N2CC(F)C2)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		6852376	91599	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		CHEMBL1467585	91599	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		CHEMBL24077	91599	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		CHEMBL503958	91599	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		15711869	13340	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1192194	13340	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL543390	13340	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		15937729	118162	0	None	301	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	277	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL340855	118162	0	None	301	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	277	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		70690500	76073	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	76073	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		44401164	69816	0	None	-19	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	69816	0	None	-19	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		15115525	109690	0	None	134	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	509	4	2	8	5.0	CN1CCc2cc(Br)c(O)cc2C(c2ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc2)C1	10.1021/jm00115a012
		CHEMBL322760	109690	0	None	134	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	509	4	2	8	5.0	CN1CCc2cc(Br)c(O)cc2C(c2ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc2)C1	10.1021/jm00115a012
		134155502	151428	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	341	3	2	5	3.2	CCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3961827	151428	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	341	3	2	5	3.2	CCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		15696466	4267	0	None	208	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00114a002
		CHEMBL100572	4267	0	None	208	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00114a002
		44320050	106831	0	None	138	3	Rat	8.3	pKi	=	8.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL314459	106831	0	None	138	3	Rat	8.3	pKi	=	8.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		86764106	132433	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	4	4.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697574	132433	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	4	4.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		44356291	22735	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	269	1	3	3	2.7	C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm960318v
		CHEMBL132766	22735	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	269	1	3	3	2.7	C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm960318v
		162643108	181656	0	None	83	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	335	1	1	3	5.0	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4776090	181656	0	None	83	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	335	1	1	3	5.0	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2020.127563
		71563083	87572	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335737	87572	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		10742	3617	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
		1225	3617	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
		CHEMBL35354	3617	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
		5290	200033	40	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)C1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL595489	200033	40	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)C1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		46231769	201057	0	None	371	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)C4CC4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL602659	201057	0	None	371	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)C4CC4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		15937718	115233	0	None	48	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	251	2	1	2	3.2	C=CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL334728	115233	0	None	48	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	251	2	1	2	3.2	C=CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		10732044	84413	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2114440	84413	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2219804	84413	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		46231771	200980	0	None	107	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL602052	200980	0	None	107	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		11727683	62049	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	345	1	0	4	4.2	CN1CCCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL177455	62049	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	345	1	0	4	4.2	CN1CCCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		6917970	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
		8370	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
		CHEMBL487387	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
		6917970	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
		8370	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
		CHEMBL487387	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
		161665	172585	35	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL448891	172585	35	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		2389	3331	118	None	-346	67	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		5073	3331	118	None	-346	67	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		96	3331	118	None	-346	67	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		CHEMBL85	3331	118	None	-346	67	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		DB00734	3331	118	None	-346	67	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		2726	919	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		621	919	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		83	919	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		CHEMBL71	919	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		DB00477	919	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		71109989	153775	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3982119	153775	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		2407	3372	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		59227	3372	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		941	3372	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		CHEMBL1303	3372	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		DB05271	3372	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		3716121	84081	16	None	-1258	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	332	4	0	3	4.1	COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207643	84081	16	None	-1258	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	332	4	0	3	4.1	COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		145986441	167172	0	None	-147	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	432	7	2	4	3.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4291172	167172	0	None	-147	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	432	7	2	4	3.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2	10.1021/acsmedchemlett.8b00229
		71454294	84077	0	None	-1096	7	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207639	84077	0	None	-1096	7	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		1577	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		2537	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		5355	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		5501	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		643497	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		688272	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		958	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		960	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		CHEMBL196677	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		CHEMBL26	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		CHEMBL267044	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		DB00391	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		DB16021	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		1577	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		2537	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		5355	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		5501	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		643497	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		688272	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		958	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		960	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		CHEMBL196677	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		CHEMBL26	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		CHEMBL267044	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		DB00391	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		DB16021	3703	110	None	-70	21	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		10827222	6985	1	None	-457	5	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligandBinding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand	ChEMBL	288	3	0	2	3.6	C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1	10.1021/jm950721m
		CHEMBL108463	6985	1	None	-457	5	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligandBinding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand	ChEMBL	288	3	0	2	3.6	C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1	10.1021/jm950721m
		45481875	198119	0	None	-12	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL574595	198119	0	None	-12	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		10939222	204402	1	None	-1000	5	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	445	8	1	4	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL71960	204402	1	None	-1000	5	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	445	8	1	4	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1	10.1016/0960-894X(95)00011-H
		44415825	81116	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	573	4	1	5	6.8	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccccc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL215641	81116	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	573	4	1	5	6.8	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccccc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		44415786	80050	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	549	6	1	5	6.9	CCC(CC)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212966	80050	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	549	6	1	5	6.9	CCC(CC)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		25141538	56241	0	None	-2089	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
		CHEMBL1627311	56241	0	None	-2089	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
		154705884	176363	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4469584	176363	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595726	176363	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		11522476	74523	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2	10.1021/jm050846j
		CHEMBL202924	74523	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2	10.1021/jm050846j
		162660874	181883	0	None	9	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4779001	181883	0	None	9	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		86764103	132437	13	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		CHEMBL3697578	132437	13	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		75201899	171916	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		CHEMBL4469983	171916	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		44415838	139080	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL378648	139080	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415560	80370	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	4	1	6	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Oc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL214407	80370	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	4	1	6	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Oc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		9883454	113966	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL332600	113966	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		10758745	100433	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115373	100433	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL290438	100433	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		9883454	113966	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL332600	113966	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		56833378	68333	0	None	-281	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1121	39	2	14	10.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		CHEMBL1916549	68333	0	None	-281	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1121	39	2	14	10.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		10665598	35083	1	None	-30	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1	10.1021/jm0009989
		CHEMBL143355	35083	1	None	-30	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1	10.1021/jm0009989
		164609519	184451	0	None	-426	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2	10.1016/j.bmcl.2021.128047
		CHEMBL4846574	184451	0	None	-426	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2	10.1016/j.bmcl.2021.128047
		44454685	95053	0	None	-63	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1	10.1016/j.bmcl.2007.12.026
		CHEMBL255163	95053	0	None	-63	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1	10.1016/j.bmcl.2007.12.026
		44380715	59013	0	None	-269	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL169222	59013	0	None	-269	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		155569483	176199	0	None	-154	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	2	2	5	2.9	CCNc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
		CHEMBL4593728	176199	0	None	-154	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	2	2	5	2.9	CCNc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
		14787977	198882	2	None	1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		CHEMBL58422	198882	2	None	1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		14787976	196980	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL56666	196980	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		44405965	75013	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	449	5	2	5	3.2	O=c1[nH]c2[nH]c(-c3ccccc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		CHEMBL203362	75013	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	449	5	2	5	3.2	O=c1[nH]c2[nH]c(-c3ccccc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		135398745	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		47	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		CHEMBL715	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		DB00334	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		44320092	161887	0	None	39	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL415080	161887	0	None	39	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		57401820	70161	0	None	-6	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	364	6	0	3	4.8	Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940409	70161	0	None	-6	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	364	6	0	3	4.8	Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		135398745	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		47	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		CHEMBL715	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		DB00334	2914	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		10592479	100265	0	None	48	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL288846	100265	0	None	48	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		21302490	112805	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
		CHEMBL3233142	112805	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
		CHEMBL3306803	112805	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
		74223829	129448	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	351	3	1	5	4.5	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1Cl	nan
		CHEMBL3671303	129448	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	351	3	1	5	4.5	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1Cl	nan
		70686343	76072	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057454	76072	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		56971028	69245	0	None	-3	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	392	8	1	6	2.5	CCOc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1	10.1016/j.ejmech.2011.11.023
		CHEMBL1927090	69245	0	None	-3	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	392	8	1	6	2.5	CCOc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1	10.1016/j.ejmech.2011.11.023
		15711865	13175	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL1190906	13175	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL541838	13175	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		117774289	132412	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.1	CCc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		CHEMBL3697553	132412	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.1	CCc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		164585473	184562	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4848380	184562	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		44393372	66326	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	549	8	1	5	4.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1	10.1016/j.bmcl.2004.05.052
		CHEMBL184993	66326	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	549	8	1	5	4.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1	10.1016/j.bmcl.2004.05.052
		1257607	155312	2	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	433	4	0	5	4.2	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL403032	155312	2	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	433	4	0	5	4.2	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		45268293	196135	0	None	-20	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	408	4	1	7	1.4	Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL561123	196135	0	None	-20	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	408	4	1	7	1.4	Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		10854877	142015	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL38757	142015	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		44454711	97519	0	None	-3311	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1	10.1016/j.bmcl.2007.12.026
		CHEMBL270408	97519	0	None	-3311	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1	10.1016/j.bmcl.2007.12.026
		10001207	165321	0	None	-114	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL423440	165321	0	None	-114	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44567597	169464	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	592	5	4	8	5.5	CN1CCc2cc(OCCOc3cc4c5c(c3)-c3c(ccc(O)c3O)C[C@H]5N(C)CC4)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		CHEMBL442926	169464	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	592	5	4	8	5.5	CN1CCc2cc(OCCOc3cc4c5c(c3)-c3c(ccc(O)c3O)C[C@H]5N(C)CC4)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		90644063	112035	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289648	112035	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		14198596	101643	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	101643	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		135221	145219	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3912606	145219	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		90644063	112035	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289648	112035	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		10826687	50949	0	None	-4	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1ccc2c(c1)CC1c3c(cccc3O2)CCN1C	10.1021/jm991034o
		CHEMBL157799	50949	0	None	-4	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1ccc2c(c1)CC1c3c(cccc3O2)CCN1C	10.1021/jm991034o
		44569447	178755	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	323	2	0	4	3.4	COc1cc2c3c(c1)-c1c(cccc1OC(C)=O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.11.025
		CHEMBL468677	178755	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	323	2	0	4	3.4	COc1cc2c3c(c1)-c1c(cccc1OC(C)=O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.11.025
		1152279	30736	7	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL1395394	30736	7	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		135398737	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		38	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		722	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		CHEMBL42	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		DB00363	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		135398737	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	958	93	None	-44	89	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		228	445	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		33	445	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		6005	445	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		CHEMBL53	445	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		DB00714	445	28	None	-30	24	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		11782988	11641	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL118092	11641	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		14198586	201833	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		CHEMBL60706	201833	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		14198586	201833	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00118a012
		CHEMBL60706	201833	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00118a012
		14198586	201833	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Compound was evaluated for the binding affinity against dopamine (D1) receptorCompound was evaluated for the binding affinity against dopamine (D1) receptor	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		CHEMBL60706	201833	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Compound was evaluated for the binding affinity against dopamine (D1) receptorCompound was evaluated for the binding affinity against dopamine (D1) receptor	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		11782988	11641	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL118092	11641	0	None	-1	3	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		86767100	124438	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)c(F)c1F	nan
		CHEMBL3639701	124438	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)c(F)c1F	nan
		44320256	206313	0	None	5	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87172	206313	0	None	5	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		188442	87509	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3O)C[C@@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL2334887	87509	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3O)C[C@@H]21	10.1016/j.bmc.2012.12.016
		15467371	101007	0	None	-912	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL294458	101007	0	None	-912	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		10831735	31755	0	None	-2511	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL140594	31755	0	None	-2511	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1	10.1021/jm0009989
		10567430	119293	1	None	-1445	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1	10.1021/jm0009989
		CHEMBL343880	119293	1	None	-1445	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1	10.1021/jm0009989
		44340097	9440	0	None	-4365	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL111749	9440	0	None	-4365	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		44567595	175277	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	327	3	3	5	2.2	CN1CCc2cc(OCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		CHEMBL457275	175277	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	327	3	3	5	2.2	CN1CCc2cc(OCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		137645830	157852	0	None	-131	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
		CHEMBL4083727	157852	0	None	-131	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
		11615489	69443	1	None	-588	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@H]1CCn2nccc2C1	10.1021/jm101639t
		CHEMBL193337	69443	1	None	-588	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@H]1CCn2nccc2C1	10.1021/jm101639t
		14787976	196980	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00170a025
		CHEMBL56666	196980	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00170a025
		14787977	198882	2	None	-1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		CHEMBL58422	198882	2	None	-1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		156012880	177442	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	364	4	0	5	3.4	C#CCOc1c(OC)cc2c3c1-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4638749	177442	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	364	4	0	5	3.4	C#CCOc1c(OC)cc2c3c1-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		10809188	9275	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL110847	9275	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL540822	9275	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		150	2509	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	2509	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	2509	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	2509	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	2509	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		135398737	958	93	None	-83	89	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		38	958	93	None	-83	89	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		722	958	93	None	-83	89	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		CHEMBL42	958	93	None	-83	89	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		DB00363	958	93	None	-83	89	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		44415824	81212	0	None	13	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	3	1	5	5.5	CCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL215842	81212	0	None	13	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	3	1	5	5.5	CCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		117772871	132480	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697621	132480	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		86767099	129434	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1cc(F)c(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671290	129434	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1cc(F)c(Oc2nccc3[nH]ccc23)cc1F	nan
		135398737	958	93	None	-44	89	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		38	958	93	None	-44	89	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		722	958	93	None	-44	89	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		CHEMBL42	958	93	None	-44	89	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		DB00363	958	93	None	-44	89	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		57390118	69302	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928126	69302	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		12997400	101004	7	None	-53	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	241	3	1	2	2.3	c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1	10.1016/s0960-894x(02)00316-5
		CHEMBL294394	101004	7	None	-53	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	241	3	1	2	2.3	c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1	10.1016/s0960-894x(02)00316-5
		122132	202564	17	None	-87	4	Human	5.3	pKi	=	5.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm9800292
		CHEMBL611801	202564	17	None	-87	4	Human	5.3	pKi	=	5.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm9800292
		44454735	95317	0	None	-2951	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	374	8	0	5	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		CHEMBL256492	95317	0	None	-2951	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	374	8	0	5	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		25131136	187511	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	504	9	2	5	6.2	CCCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL494308	187511	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	504	9	2	5	6.2	CCCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		49782837	17585	0	None	-44	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	472	6	0	3	6.0	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1258154	17585	0	None	-44	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	472	6	0	3	6.0	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		137645574	157803	0	None	-5754	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	462	7	3	6	3.1	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4083239	157803	0	None	-5754	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	462	7	3	6	3.1	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		72545009	93124	0	None	-109	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443002	93124	0	None	-109	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1	10.1016/j.bmcl.2013.09.026
		145970938	165156	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	233	5	1	2	3.4	CCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4228054	165156	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	233	5	1	2	3.4	CCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		11698732	72745	0	None	2	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		CHEMBL199876	72745	0	None	2	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		44304643	203275	0	None	-8	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	8	0	5	5.1	COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64668	203275	0	None	-8	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	8	0	5	5.1	COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		3168	9262	92	None	-89	21	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	9262	92	None	-89	21	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		162665267	182182	0	None	21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.6	CN1CCC(C2=Nc3cc(Cl)ccc3Nc3ccccc32)=CC1(C)C	10.1016/j.bmcl.2020.127563
		CHEMBL4782694	182182	0	None	21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.6	CN1CCC(C2=Nc3cc(Cl)ccc3Nc3ccccc32)=CC1(C)C	10.1016/j.bmcl.2020.127563
		1353	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	1911	93	None	-38	83	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		117774669	132479	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.0	CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)c(C)c(=O)[nH]c1=O	nan
		CHEMBL3697620	132479	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.0	CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)c(C)c(=O)[nH]c1=O	nan
		71454927	84592	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
		CHEMBL2158636	84592	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
		CHEMBL2221040	84592	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
		10641637	118780	0	None	-19	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1	10.1021/jm0009989
		CHEMBL342001	118780	0	None	-19	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1	10.1021/jm0009989
		118709172	113419	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	493	8	0	4	6.6	Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318844	113419	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	493	8	0	4	6.6	Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2014.06.079
		10336538	1625	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
		974	1625	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
		CHEMBL310843	1625	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
		10336538	1625	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
		974	1625	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
		CHEMBL310843	1625	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
		44436597	91800	0	None	-251	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241210	91800	0	None	-251	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		11559581	78418	0	None	-2754	6	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	3	0	5	3.4	Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL211135	78418	0	None	-2754	6	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	3	0	5	3.4	Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		11654739	176848	0	None	-20417	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		CHEMBL461236	176848	0	None	-20417	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		71734031	91060	0	None	-22908	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		CHEMBL2397479	91060	0	None	-22908	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		10336538	1625	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
		974	1625	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
		CHEMBL310843	1625	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
		10336538	1625	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
		974	1625	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
		CHEMBL310843	1625	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
		44537919	198136	0	None	-28	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL574700	198136	0	None	-28	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		10811026	28547	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	9	2	3	4.3	O=CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL137636	28547	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	9	2	3	4.3	O=CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		2398	954	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	954	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	954	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	954	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	954	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		6852376	91599	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL1467585	91599	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL24077	91599	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL503958	91599	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		44415802	80207	0	None	14	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213668	80207	0	None	14	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415383	81451	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	5	1	6	5.4	COc1ccc(CCC(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1Cl	10.1016/j.bmcl.2006.06.022
		CHEMBL215950	81451	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	5	1	6	5.4	COc1ccc(CCC(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1Cl	10.1016/j.bmcl.2006.06.022
		25110708	12609	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186978	12609	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL485207	12609	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		130442561	166893	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4286110	166893	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		44276405	100109	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
		CHEMBL287513	100109	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
		44412191	138375	0	None	-107	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1	10.1016/j.bmcl.2006.02.075
		CHEMBL377200	138375	0	None	-107	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1	10.1016/j.bmcl.2006.02.075
		11071135	208008	0	None	-2570	7	Rat	5.3	pKi	=	5.3	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	500	6	0	6	4.6	CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O	10.1021/jm020938y
		CHEMBL97333	208008	0	None	-2570	7	Rat	5.3	pKi	=	5.3	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	500	6	0	6	4.6	CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O	10.1021/jm020938y
		11661609	79693	0	None	-5623	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	414	4	0	5	3.7	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1	10.1021/jm060166w
		CHEMBL211539	79693	0	None	-5623	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	414	4	0	5	3.7	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1	10.1021/jm060166w
		44339879	172282	0	None	-186	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL447476	172282	0	None	-186	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		44327153	109210	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
		CHEMBL321682	109210	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
		CHEMBL558817	109210	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
		10738274	164891	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(Br)cc(OC)c2C1Cc1ccccc1O	10.1021/jm991034o
		CHEMBL422169	164891	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(Br)cc(OC)c2C1Cc1ccccc1O	10.1021/jm991034o
		145982261	166732	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		CHEMBL4283176	166732	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		155195311	174347	0	None	-1778	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay	ChEMBL	433	7	3	5	3.4	C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acsmedchemlett.9b00660
		CHEMBL4551160	174347	0	None	-1778	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay	ChEMBL	433	7	3	5	3.4	C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acsmedchemlett.9b00660
		24949693	182304	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
		CHEMBL478413	182304	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
		14198593	198674	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		CHEMBL57988	198674	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		36791366	87504	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL2334880	87504	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		14198593	198674	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00118a012
		CHEMBL57988	198674	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00118a012
		44405985	169560	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccccc3Cl)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		CHEMBL443567	169560	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccccc3Cl)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		122132	202564	17	None	4	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm00160a018
		CHEMBL611801	202564	17	None	4	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm00160a018
		11720302	166258	0	None	-301	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	503	7	1	3	5.2	O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		CHEMBL426863	166258	0	None	-301	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	503	7	1	3	5.2	O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		10939167	9500	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
		CHEMBL112065	9500	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
		CHEMBL129483	9500	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
		44454710	155666	0	None	-478	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	378	7	0	4	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		CHEMBL404888	155666	0	None	-478	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	378	7	0	4	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		137631036	161151	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4060837	161151	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4117325	161151	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		44415623	138254	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	599	4	1	7	6.4	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL377043	138254	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	599	4	1	7	6.4	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		44316058	205537	0	None	-64	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		CHEMBL80974	205537	0	None	-64	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		10316297	124049	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		CHEMBL363124	124049	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		10316297	124049	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		CHEMBL363124	124049	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		53946796	67767	1	None	-5248	2	Rat	4.2	pKi	=	4.2	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		CHEMBL1907969	67767	1	None	-5248	2	Rat	4.2	pKi	=	4.2	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		44427970	152610	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	325	2	0	3	3.7	COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		CHEMBL397207	152610	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	325	2	0	3	3.7	COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		156010592	177128	0	None	14	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	376	4	1	4	3.4	C#CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4633772	177128	0	None	14	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	376	4	1	4	3.4	C#CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		86764321	132472	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	399	5	1	5	4.3	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1	nan
		CHEMBL3697612	132472	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	399	5	1	5	4.3	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1	nan
		117773598	132475	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.7	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2C)c(C)c(=O)[nH]c1=O	nan
		CHEMBL3697615	132475	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.7	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2C)c(C)c(=O)[nH]c1=O	nan
		164626655	186593	0	None	-16	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2	10.1016/j.bmcl.2021.128047
		CHEMBL4878587	186593	0	None	-16	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2	10.1016/j.bmcl.2021.128047
		44287454	13228	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL1191276	13228	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL542351	13228	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		1353	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		3559	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		86	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		CHEMBL54	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		DB00502	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		2389	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		5073	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		96	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		CHEMBL85	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		DB00734	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		54580906	61605	0	None	-2754	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771109	61605	0	None	-2754	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		57391895	69301	0	None	-301	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928125	69301	0	None	-301	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		3156990	8130	22	None	-28	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL109173	8130	22	None	-28	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		25139478	184956	0	None	-446	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	510	10	0	4	7.5	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		CHEMBL485384	184956	0	None	-446	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	510	10	0	4	7.5	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		15467369	100928	0	None	-6165	3	Bovine	4.2	pKi	=	4.2	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL293956	100928	0	None	-6165	3	Bovine	4.2	pKi	=	4.2	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		136043854	80187	0	None	-20	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	460	2	1	6	5.1	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc4c(c3)OCCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		CHEMBL213577	80187	0	None	-20	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	460	2	1	6	5.1	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc4c(c3)OCCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		77974401	113960	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	252	1	1	2	2.9	CN1CCc2ccc(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325920	113960	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	252	1	1	2	2.9	CN1CCc2ccc(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		154727843	176433	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4448853	176433	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4596221	176433	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		71086428	151553	0	None	-66	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3963122	151553	0	None	-66	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		3108374	91977	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		CHEMBL2414990	91977	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		107715	200945	22	None	-144	19	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	200945	22	None	-144	19	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	200945	22	None	-144	19	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		57401819	70160	0	None	-75	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940408	70160	0	None	-75	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		23364995	113420	0	None	-13	4	Pig	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	417	7	0	4	5.0	CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318845	113420	0	None	-13	4	Pig	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	417	7	0	4	5.0	CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		86764104	132481	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697622	132481	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		156020558	178046	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4647167	178046	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		44436617	91560	0	None	-20	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	481	9	1	4	4.8	COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		CHEMBL240584	91560	0	None	-20	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	481	9	1	4	4.8	COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		49782604	17523	0	None	-19	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	379	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		CHEMBL1257927	17523	0	None	-19	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	379	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		49782836	17552	0	None	-58	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	456	6	0	3	5.5	O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL1258036	17552	0	None	-58	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	456	6	0	3	5.5	O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		24841480	183899	0	None	-2951	20	Human	5.2	pKi	=	5.2	Binding	Antagonist activity at dopamine D1 receptor (unknown origin) by PDSP assayAntagonist activity at dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	183899	0	None	-2951	20	Human	5.2	pKi	=	5.2	Binding	Antagonist activity at dopamine D1 receptor (unknown origin) by PDSP assayAntagonist activity at dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		44436603	145216	0	None	-269	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		CHEMBL391257	145216	0	None	-269	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		11655570	79726	0	None	-11220	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	462	4	0	5	3.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1	10.1021/jm060166w
		CHEMBL211590	79726	0	None	-11220	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	462	4	0	5	3.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1	10.1021/jm060166w
		45267409	196161	0	None	-1513	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL561262	196161	0	None	-1513	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1	10.1016/j.bmc.2009.05.015
		71212556	143562	0	None	-120	6	Human	6.2	pKi	=	6.2	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		CHEMBL3899169	143562	0	None	-120	6	Human	6.2	pKi	=	6.2	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		8447	188949	84	None	-8	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	188949	84	None	-8	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		3191	102858	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	102858	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		145969934	165045	0	None	-54	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	261	7	1	2	4.2	CCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4226336	165045	0	None	-54	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	261	7	1	2	4.2	CCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		14198573	198083	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	1	2	3.6	COc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL574340	198083	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	1	2	3.6	COc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		130424	204345	14	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	327	1	1	3	4.4	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2cccc3ccoc23)C1	10.1021/jm00170a025
		CHEMBL71600	204345	14	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	327	1	1	3	4.4	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2cccc3ccoc23)C1	10.1021/jm00170a025
		44415827	81059	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL215414	81059	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		11619691	155056	0	None	138	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	467	3	1	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(O)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL401690	155056	0	None	138	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	467	3	1	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(O)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		5311428	100107	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1744078	100107	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL287504	100107	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		56589560	70597	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		CHEMBL1949725	70597	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		1353	1911	93	None	-38	83	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		3559	1911	93	None	-38	83	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		86	1911	93	None	-38	83	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		CHEMBL54	1911	93	None	-38	83	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		DB00502	1911	93	None	-38	83	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		6603820	95774	19	None	-4	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.ejmech.2011.11.039
		CHEMBL25856	95774	19	None	-4	13	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.ejmech.2011.11.039
		440229	87511	53	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		CHEMBL2334891	87511	53	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		6917970	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		8370	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		CHEMBL487387	3691	61	None	-1	34	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		3246443	37686	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL1457510	37686	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		9869262	104861	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		CHEMBL310997	104861	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		3246443	37686	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		CHEMBL1457510	37686	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		10709445	101363	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115377	101363	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL296993	101363	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10107367	102434	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL303993	102434	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		71261649	87512	9	None	15	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2334892	87512	9	None	15	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		10640108	84411	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2114441	84411	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2219802	84411	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		10107367	102434	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		CHEMBL303993	102434	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		14198585	100801	1	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	100801	1	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		10107367	102434	1	None	7	4	Human	8.2	pKi	=	8.2	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		CHEMBL303993	102434	1	None	7	4	Human	8.2	pKi	=	8.2	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		127031399	138742	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	2	6	2.8	COc1cc2c(cc1O)C1Cc3ccc(OCCCO)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780268	138742	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	2	6	2.8	COc1cc2c(cc1O)C1Cc3ccc(OCCCO)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		71109797	145896	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		CHEMBL3917753	145896	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		71109797	145896	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		CHEMBL3917753	145896	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		130442514	166532	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4279267	166532	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
		25110709	12606	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL1186967	12606	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL484538	12606	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
		86764103	132437	13	None	-	1	Human	8.2	pKi	=	8.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697578	132437	13	None	-	1	Human	8.2	pKi	=	8.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44415600	79785	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	461	4	1	6	4.8	COc1ccccc1CNN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL211910	79785	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	461	4	1	6	4.8	COc1ccccc1CNN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		122205437	137311	0	None	-19	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2sccc2CC1	10.1039/C5MD00258C
		CHEMBL3752512	137311	0	None	-19	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2sccc2CC1	10.1039/C5MD00258C
		12313091	86478	6	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1ccc2c(c1O)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL2314732	86478	6	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1ccc2c(c1O)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		11023546	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		11023546	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		10071501	9879	0	None	10	2	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		CHEMBL114228	9879	0	None	10	2	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		44393415	65230	0	None	-251	5	Pig	6.2	pKi	=	6.2	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	499	8	1	5	3.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1	10.1016/j.bmcl.2004.05.052
		CHEMBL182652	65230	0	None	-251	5	Pig	6.2	pKi	=	6.2	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	499	8	1	5	3.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1	10.1016/j.bmcl.2004.05.052
		137638973	156874	0	None	-1479	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4071868	156874	0	None	-1479	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		56837419	69304	0	None	-2630	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	997	35	2	14	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928128	69304	0	None	-2630	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	997	35	2	14	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		46917563	68335	0	None	-8511	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	561	18	1	7	5.5	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1	10.1021/jm2009919
		CHEMBL1916551	68335	0	None	-8511	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	561	18	1	7	5.5	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1	10.1021/jm2009919
		2780	110529	36	None	-138	10	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00678-4
		CHEMBL325109	110529	36	None	-138	10	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00678-4
		137634153	156432	0	None	-54	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	236	1	2	5	0.6	Oc1ccc(N2CCNCC2)c2c1OCCO2	10.1016/j.bmc.2017.08.037
		CHEMBL4066916	156432	0	None	-54	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	236	1	2	5	0.6	Oc1ccc(N2CCNCC2)c2c1OCCO2	10.1016/j.bmc.2017.08.037
		10775901	35779	1	None	-70	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cc(C)cc(C)c2)C1	10.1021/jm9708700
		CHEMBL144114	35779	1	None	-70	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cc(C)cc(C)c2)C1	10.1021/jm9708700
		10609576	118752	0	None	-42	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cccc(C)c2C)C1	10.1021/jm9708700
		CHEMBL341825	118752	0	None	-42	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cccc(C)c2C)C1	10.1021/jm9708700
		72545008	93123	0	None	-89	5	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	451	15	0	9	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443001	93123	0	None	-89	5	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	451	15	0	9	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		15654859	203032	0	None	4	2	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3N(C)c3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL63390	203032	0	None	4	2	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3N(C)c3ccccc32)CC1	10.1021/jm00067a009
		13994412	11164	1	None	-117	3	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL117841	11164	1	None	-117	3	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		10689791	164881	0	None	12	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	4	2	3	3.3	NCCCC(=O)N1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL422086	164881	0	None	12	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	4	2	3	3.3	NCCCC(=O)N1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		490	191	8	None	-30902	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		9890547	191	8	None	-30902	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		CHEMBL268758	191	8	None	-30902	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		10015045	13652	1	None	-6	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm9015763
		CHEMBL119455	13652	1	None	-6	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm9015763
		9992499	73386	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
		CHEMBL201483	73386	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
		72699816	115187	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	329	3	1	4	4.1	CCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344457	115187	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	329	3	1	4	4.1	CCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		145966311	164033	0	None	-3388	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells	ChEMBL	378	5	1	4	2.9	O=C(NCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccccn1	10.1016/j.bmc.2017.09.018
		CHEMBL4208744	164033	0	None	-3388	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells	ChEMBL	378	5	1	4	2.9	O=C(NCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccccn1	10.1016/j.bmc.2017.09.018
		57402366	69315	0	None	-1230	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1033	32	2	17	5.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928139	69315	0	None	-1230	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1033	32	2	17	5.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		44340333	9662	0	None	-1071	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL112833	9662	0	None	-1071	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44340227	110641	0	None	-2137	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325772	110641	0	None	-2137	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		10265732	94849	0	None	2	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253738	94849	0	None	2	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		2477	745	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		36	745	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		437	745	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		CHEMBL49	745	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		DB00490	745	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		15508242	165249	0	None	-64	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		CHEMBL422959	165249	0	None	-64	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		838674	107425	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL318111	107425	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL542493	107425	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		44316331	205499	0	None	-41	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		CHEMBL80686	205499	0	None	-41	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		10378389	203245	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL134807	203245	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL64553	203245	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		838674	107425	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL318111	107425	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL542493	107425	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		71817345	91979	0	None	-158	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		CHEMBL2414992	91979	0	None	-158	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		44415567	80035	0	None	58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212905	80035	0	None	58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415579	79845	0	None	61	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	542	4	2	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3NC3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212186	79845	0	None	61	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	542	4	2	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3NC3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		72699817	115188	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344458	115188	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		46931072	202045	1	None	-8	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL608530	202045	1	None	-8	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		2389	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		5073	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		96	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		CHEMBL85	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		DB00734	3331	118	None	-489	67	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		122189391	123246	0	None	-72	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	431	7	0	9	2.1	COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		CHEMBL3613877	123246	0	None	-72	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	431	7	0	9	2.1	COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		44264742	97174	0	None	-13	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	298	3	0	4	2.8	c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(98)00692-1
		CHEMBL268190	97174	0	None	-13	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	298	3	0	4	2.8	c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(98)00692-1
		2	3261	23	None	-977	29	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
		54562	3261	23	None	-977	29	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
		CHEMBL240773	3261	23	None	-977	29	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
		11023546	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		9839050	112379	0	None	-131	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		CHEMBL329566	112379	0	None	-131	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		117773522	132444	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	6	3.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697585	132444	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	6	3.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		24863698	176698	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	253	0	2	2	2.7	Oc1ccc2c(c1)CCNCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL459871	176698	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	253	0	2	2	2.7	Oc1ccc2c(c1)CCNCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		11023546	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	78478	0	None	-5	4	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		3108374	91977	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		CHEMBL2414990	91977	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		44400626	70402	0	None	-999	5	Pig	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL194555	70402	0	None	-999	5	Pig	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		44403214	72493	0	None	-446	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL198993	72493	0	None	-446	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1	10.1016/j.bmcl.2005.07.037
		44448063	155245	0	None	3	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL402736	155245	0	None	3	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		154727713	176364	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4514586	176364	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4595727	176364	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		118717797	115193	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	2	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344463	115193	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	2	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		10758760	22501	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	329	4	1	2	4.8	CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL132545	22501	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	329	4	1	2	4.8	CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		161379	187215	8	None	-79	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		CHEMBL492418	187215	8	None	-79	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		154703438	176381	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4475699	176381	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595859	176381	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		136043857	79786	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	5.0	Clc1ccc2c(c1)N=C(N1CCN(Cc3cccc4c3OCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		CHEMBL211915	79786	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	5.0	Clc1ccc2c(c1)N=C(N1CCN(Cc3cccc4c3OCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		44281881	99849	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL1743774	99849	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL285717	99849	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		1242	3613	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		935	3613	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		CHEMBL286080	3613	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		44415743	80108	0	None	30	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213201	80108	0	None	30	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		6852376	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		CHEMBL1467585	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		CHEMBL24077	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		CHEMBL503958	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		6852376	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		CHEMBL1467585	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		CHEMBL24077	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		CHEMBL503958	91599	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		1242	3613	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		935	3613	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		CHEMBL286080	3613	27	None	1	18	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		70684206	76065	0	None	11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057442	76065	0	None	11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692653	76066	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL2057443	76066	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		70692652	76064	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		CHEMBL2057441	76064	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		54580905	61603	0	None	-2570	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771107	61603	0	None	-2570	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		56594533	70598	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		CHEMBL1949726	70598	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		56837634	69306	0	None	-1479	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1041	38	2	15	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928130	69306	0	None	-1479	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1041	38	2	15	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		9796958	146578	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115374	146578	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL39230	146578	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL544814	146578	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		11633170	78412	0	None	-2818	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	421	5	0	7	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1	10.1021/jm060166w
		CHEMBL211118	78412	0	None	-2818	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	421	5	0	7	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1	10.1021/jm060166w
		11583188	139282	0	None	-19498	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	448	4	0	5	3.3	COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1	10.1021/jm060166w
		CHEMBL379125	139282	0	None	-19498	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	448	4	0	5	3.3	COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1	10.1021/jm060166w
		10355510	155662	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL404865	155662	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		71461481	84070	0	None	-676	5	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	356	4	0	3	4.1	C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		CHEMBL2207632	84070	0	None	-676	5	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	356	4	0	3	4.1	C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		71450707	84078	0	None	-1698	7	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	444	6	0	5	3.9	COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207640	84078	0	None	-1698	7	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	444	6	0	5	3.9	COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		25131135	187548	0	None	-8511	3	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	448	6	3	5	4.7	Nc1nc2c(s1)C[C@@H](NCC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		CHEMBL494510	187548	0	None	-8511	3	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	448	6	3	5	4.7	Nc1nc2c(s1)C[C@@H](NCC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		90644058	112029	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289642	112029	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		90644058	112029	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289642	112029	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		130907	194683	5	None	-3311	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm701045j
		CHEMBL53294	194683	5	None	-3311	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm701045j
		64143	198864	62	None	-1	8	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		CHEMBL584	198864	62	None	-1	8	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		154725277	176432	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4472900	176432	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596220	176432	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		10015860	99277	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL281932	99277	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		44415598	78018	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		CHEMBL209805	78018	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		44415612	138955	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	6	6.0	CCOc1ccc2ccccc2c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL378512	138955	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	6	6.0	CCOc1ccc2ccccc2c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		134149077	148323	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	4	2	5	3.9	CCC(C)Oc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3936976	148323	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	4	2	5	3.9	CCC(C)Oc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		681	1465	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	1465	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	1465	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	1465	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	1465	72	None	-23	39	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		228	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		33	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		6005	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL53	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		DB00714	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		117774495	132424	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	396	4	1	6	2.7	Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697565	132424	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	396	4	1	6	2.7	Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		40152769	201808	2	None	-107	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL606939	201808	2	None	-107	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		45481888	199014	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL585740	199014	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		21171	186976	33	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL490533	186976	33	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		135515431	4247	34	None	-10	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
		CHEMBL100454	4247	34	None	-10	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
		72699818	115195	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	341	3	1	4	4.1	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344466	115195	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	341	3	1	4	4.1	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		11504230	78217	0	None	-870	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		CHEMBL210567	78217	0	None	-870	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		228	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		33	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		6005	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		CHEMBL53	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		DB00714	445	28	None	-35	24	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		44448061	94847	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253736	94847	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		45270813	196689	0	None	-776	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1	10.1016/j.bmc.2009.05.015
		CHEMBL564709	196689	0	None	-776	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1	10.1016/j.bmc.2009.05.015
		71457956	78424	0	None	-87	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111527	78424	0	None	-87	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		76325152	106371	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3115579	106371	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3139262	106371	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		10037962	206707	0	None	-51	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1ABinding affinity against dopamine receptor D1A	ChEMBL	254	0	1	2	3.4	c1cc2c3c(c1)c1c(n3CCNC2)CCCCCC1	10.1016/j.bmcl.2004.02.100
		CHEMBL89738	206707	0	None	-51	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1ABinding affinity against dopamine receptor D1A	ChEMBL	254	0	1	2	3.4	c1cc2c3c(c1)c1c(n3CCNC2)CCCCCC1	10.1016/j.bmcl.2004.02.100
		118711254	113952	0	None	-147	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	358	4	2	3	4.6	CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325904	113952	0	None	-147	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	358	4	2	3	4.6	CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		42626315	56250	0	None	-1445	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		CHEMBL1627320	56250	0	None	-1445	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		10363751	163080	0	None	-1584	3	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	402	6	0	4	3.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(F)cc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL417661	163080	0	None	-1584	3	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	402	6	0	4	3.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(F)cc2)C1	10.1016/s0960-894x(99)00201-2
		45269974	13622	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1194307	13622	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL550792	13622	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		91899756	129439	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cc(=O)[nH]nc1C	nan
		CHEMBL3671295	129439	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cc(=O)[nH]nc1C	nan
		9888555	165604	16	None	-3235	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
		CHEMBL424294	165604	16	None	-3235	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
		25071691	111787	0	None	-2818	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287403	111787	0	None	-2818	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		6469918	79891	13	None	-954	6	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL212370	79891	13	None	-954	6	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		71450812	78422	0	None	-338	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111525	78422	0	None	-338	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		3036864	202754	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1256645	202754	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1814790	202754	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL62	202754	19	None	-2	28	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		10360174	168248	1	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	344	0	0	5	3.5	CN1CCN(C2=Nc3cccnc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL433744	168248	1	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	344	0	0	5	3.5	CN1CCN(C2=Nc3cccnc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		10660476	47373	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		CHEMBL154468	47373	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		15654856	203024	0	None	2	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	311	0	1	5	2.6	CN1CCN(C2=Nc3cccnc3Nc3ccc(F)cc32)CC1	10.1021/jm00067a009
		CHEMBL63347	203024	0	None	2	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	311	0	1	5	2.6	CN1CCN(C2=Nc3cccnc3Nc3ccc(F)cc32)CC1	10.1021/jm00067a009
		42625207	56234	0	None	-257	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		CHEMBL1627304	56234	0	None	-257	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		44323890	206917	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	316	1	0	2	4.2	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL90977	206917	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	316	1	0	2	4.2	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		3039881	174257	10	None	4	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL45491	174257	10	None	4	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		44415638	79884	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212334	79884	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415490	139238	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C(F)(F)F)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL378886	139238	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C(F)(F)F)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		134150645	151645	0	None	10	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	475	7	2	5	5.5	CCCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3963862	151645	0	None	10	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	475	7	2	5	5.5	CCCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		44300069	196117	0	None	35	2	Rat	7.2	pKi	=	7.2	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL56100	196117	0	None	35	2	Rat	7.2	pKi	=	7.2	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		41532205	78277	1	None	-954	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL210717	78277	1	None	-954	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		11504230	78217	0	None	-1023	7	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm100899z
		CHEMBL210567	78217	0	None	-1023	7	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm100899z
		145990141	166779	0	None	-323	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	388	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4283982	166779	0	None	-323	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	388	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2	10.1021/acsmedchemlett.8b00229
		44454709	97518	0	None	-5248	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	404	9	0	6	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		CHEMBL270406	97518	0	None	-5248	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	404	9	0	6	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		12888943	9569	0	None	-812	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL112395	9569	0	None	-812	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl	10.1016/s0960-894x(03)00678-4
		10660476	47373	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		CHEMBL154468	47373	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		25139332	184319	0	None	-7	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	352	11	1	2	5.0	CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		CHEMBL484204	184319	0	None	-7	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	352	11	1	2	5.0	CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		16121920	195875	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	380	5	1	6	2.7	COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL558838	195875	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	380	5	1	6	2.7	COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1	10.1016/j.bmc.2009.05.015
		45267435	195991	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12	10.1016/j.bmc.2009.05.015
		CHEMBL559868	195991	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12	10.1016/j.bmc.2009.05.015
		52937776	61170	0	None	-9549	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1	10.1021/jm101639t
		CHEMBL1765629	61170	0	None	-9549	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1	10.1021/jm101639t
		127046948	140070	0	None	-295	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800468	140070	0	None	-295	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		118709168	113415	0	None	-33	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1000	29	0	8	14.4	O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318840	113415	0	None	-33	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1000	29	0	8	14.4	O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		12050200	102090	0	None	-128	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	6	1	4	4.6	c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL302186	102090	0	None	-128	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	6	1	4	4.6	c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		11708363	71902	1	None	-23	4	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
		CHEMBL197159	71902	1	None	-23	4	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
		44329057	207995	0	None	-93	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97283	207995	0	None	-93	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		86767109	129446	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	6	3.5	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		CHEMBL3671301	129446	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	6	3.5	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		52940985	17586	0	None	-69	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1258155	17586	0	None	-69	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		10666053	100386	0	None	-1	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL289927	100386	0	None	-1	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		156013324	177493	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	310	2	1	4	3.0	COc1cc2c3c(c1OC)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4639398	177493	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	310	2	1	4	3.0	COc1cc2c3c(c1OC)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		76325152	106371	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3115579	106371	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3139262	106371	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		90140337	129414	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	4	2	6	3.1	COc1cnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c2c[nH]nc12	nan
		CHEMBL3671271	129414	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	4	2	6	3.1	COc1cnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c2c[nH]nc12	nan
		10333842	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL27559	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		10333842	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.06.016
		CHEMBL27559	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.06.016
		10333842	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.11.025
		CHEMBL27559	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.11.025
		681	1465	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	1465	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	1465	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	1465	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	1465	72	None	-23	39	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		14371639	103123	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00170a025
		CHEMBL307790	103123	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00170a025
		46231646	200465	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL598515	200465	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		14371639	103123	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00081a010
		CHEMBL307790	103123	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00081a010
		44415826	80391	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL214503	80391	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415705	138666	0	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	2	2	6	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL377756	138666	0	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	2	2	6	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		1218	3616	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
		938	3616	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
		CHEMBL353335	3616	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
		11306892	201306	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)Nc4c(Cl)cccc4Cl)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL604129	201306	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)Nc4c(Cl)cccc4Cl)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		15069446	198711	0	None	213	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	293	0	1	2	3.6	Cc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		CHEMBL58205	198711	0	None	213	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	293	0	1	2	3.6	Cc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		44415594	80259	0	None	177	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213882	80259	0	None	177	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		135398737	958	93	None	-44	89	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		38	958	93	None	-44	89	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		722	958	93	None	-44	89	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		CHEMBL42	958	93	None	-44	89	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		DB00363	958	93	None	-44	89	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		71109804	87506	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	10.1016/j.bmc.2012.12.016
		CHEMBL2334882	87506	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	10.1016/j.bmc.2012.12.016
		71109805	87505	0	None	27	3	Human	8.1	pKi	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		CHEMBL2334881	87505	0	None	27	3	Human	8.1	pKi	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		15937727	116578	0	None	158	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	307	1	1	2	4.6	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL336532	116578	0	None	158	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	307	1	1	2	4.6	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCCC2)C1	10.1016/S0960-894X(00)80155-9
		11536995	139555	1	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		CHEMBL379662	139555	1	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		86764210	132438	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	1	4	4.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697579	132438	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	1	4	4.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		44415552	80240	0	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		CHEMBL213795	80240	0	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		134157446	153786	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	371	5	2	6	2.8	COCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3982215	153786	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	371	5	2	6	2.8	COCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		9901453	128488	0	None	-2	3	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	315	1	0	4	3.3	CN1CCN(C2=Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm0309811
		CHEMBL366679	128488	0	None	-2	3	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	315	1	0	4	3.3	CN1CCN(C2=Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm0309811
		44415595	79893	0	None	27	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	3	1	6	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212383	79893	0	None	27	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	3	1	6	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		127031423	138762	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	369	5	1	5	3.9	CCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3780506	138762	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	369	5	1	5	3.9	CCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		162672733	183019	0	None	102	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	317	1	1	3	4.8	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4793813	183019	0	None	102	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	317	1	1	3	4.8	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		44316024	205453	0	None	-2	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	249	5	2	3	2.9	CCCCN1CCCC1Cc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		CHEMBL80369	205453	0	None	-2	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	249	5	2	3	2.9	CCCCN1CCCC1Cc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		70690498	76067	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057445	76067	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		74223774	129425	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	5	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc2nccn12	nan
		CHEMBL3671282	129425	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	5	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc2nccn12	nan
		17756213	149704	1	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm070388+
		CHEMBL394779	149704	1	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm070388+
		135398745	2914	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		47	2914	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		CHEMBL715	2914	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		DB00334	2914	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		10540201	100229	0	None	4	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL288536	100229	0	None	4	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
		1353	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		3559	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		86	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		CHEMBL54	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		DB00502	1911	93	None	-74	83	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		10333842	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL27559	98431	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		13678336	201982	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	289	1	3	3	3.1	Oc1c(O)c(-c2ccccc2)c2c(c1Cl)CCNCC2	10.1021/jm00160a018
		CHEMBL60808	201982	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	289	1	3	3	3.1	Oc1c(O)c(-c2ccccc2)c2c(c1Cl)CCNCC2	10.1021/jm00160a018
		10610641	98919	0	None	-47	5	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL27940	98919	0	None	-47	5	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		11638780	77095	0	None	-1737	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	345	3	0	5	2.8	Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL207488	77095	0	None	-1737	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	345	3	0	5	2.8	Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		70686495	76569	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccc(Br)cc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		CHEMBL2062856	76569	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccc(Br)cc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		44372198	49140	0	None	-239	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	420	4	0	4	5.1	Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL156198	49140	0	None	-239	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	420	4	0	4	5.1	Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1	10.1016/s0960-894x(01)00814-9
		44270444	49324	0	None	-138	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		CHEMBL156369	49324	0	None	-138	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		11078813	112018	0	None	-19	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	356	4	1	5	2.8	OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		CHEMBL328925	112018	0	None	-19	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	356	4	1	5	2.8	OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		12928483	13347	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
		CHEMBL1192258	13347	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
		CHEMBL543472	13347	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
		44320116	164108	0	None	7	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL420972	164108	0	None	7	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		10810641	9392	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL111509	9392	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL544089	9392	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
		156011233	177299	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	334	3	1	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4636589	177299	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	334	3	1	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		44415599	138451	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccccc1S(=O)(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL377452	138451	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccccc1S(=O)(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		9857902	60804	0	None	-26	5	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		CHEMBL176169	60804	0	None	-26	5	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		15115512	9397	7	None	-104	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	324	6	2	3	3.8	CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL111532	9397	7	None	-104	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	324	6	2	3	3.8	CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		25093832	155880	0	None	-2290	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4060461	155880	0	None	-2290	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		11574902	78450	0	None	-28183	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	400	4	0	5	3.4	COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1	10.1021/jm060166w
		CHEMBL211164	78450	0	None	-28183	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	400	4	0	5	3.4	COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1	10.1021/jm060166w
		44339953	109700	0	None	-707	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		CHEMBL322802	109700	0	None	-707	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		17469721	78025	5	None	-22	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	320	4	0	6	2.0	c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL209832	78025	5	None	-22	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	320	4	0	6	2.0	c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1	10.1016/j.bmcl.2006.02.075
		45271691	195553	0	None	-107	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	369	3	0	5	3.6	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL554692	195553	0	None	-107	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	369	3	0	5	3.6	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		44372338	53846	0	None	-2511	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	398	4	0	4	3.9	C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL160454	53846	0	None	-2511	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	398	4	0	4	3.9	C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		44329099	208081	0	None	-40	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97750	208081	0	None	-40	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		25186023	187744	0	None	-50118	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	10.1021/jm800689g
		CHEMBL495572	187744	0	None	-50118	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	10.1021/jm800689g
		10527469	156265	3	None	-1548	15	Mouse	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		CHEMBL40650	156265	3	None	-1548	15	Mouse	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		10421583	99183	1	None	-9	5	Rat	6.1	pKi	=	6.1	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm960189i
		CHEMBL281357	99183	1	None	-9	5	Rat	6.1	pKi	=	6.1	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm960189i
		CHEMBL4520788	213975	10	None	-33	25	Human	6.1	pKi	=	6.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		72699904	115199	0	None	-60	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	377	5	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344470	115199	0	None	-60	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	377	5	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		44385715	61075	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	280	1	0	2	3.8	CN1CCc2cccc3c2c(cn3-c2ccc(F)cc2)C1	10.1016/s0960-894x(98)00138-3
		CHEMBL176476	61075	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	280	1	0	2	3.8	CN1CCc2cccc3c2c(cn3-c2ccc(F)cc2)C1	10.1016/s0960-894x(98)00138-3
		156011458	177304	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	2	2	3	3.4	COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4636741	177304	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	2	2	3	3.4	COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		228	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		33	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		6005	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		CHEMBL53	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		DB00714	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		228	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		33	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		6005	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		CHEMBL53	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		DB00714	445	28	None	-35	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		13869641	113403	0	None	-29	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	431	8	0	4	5.4	CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318824	113403	0	None	-29	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	431	8	0	4	5.4	CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		9819674	12934	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL118919	12934	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		74223827	129442	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	335	3	1	5	4.0	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		CHEMBL3671298	129442	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	335	3	1	5	4.0	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		9819674	12934	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL118919	12934	0	None	-10	5	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		11208237	100974	0	None	109	2	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	279	0	1	2	3.3	CN1CCc2ccc(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL294221	100974	0	None	109	2	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	279	0	1	2	3.3	CN1CCc2ccc(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		10849018	13937	0	None	-120	3	Rat	6.1	pKi	=	6.1	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	261	1	0	1	4.1	C=Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL119656	13937	0	None	-120	3	Rat	6.1	pKi	=	6.1	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	261	1	0	1	4.1	C=Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		44400585	68655	0	None	-1949	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL191962	68655	0	None	-1949	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		10425969	101008	3	None	-1862	4	Bovine	5.1	pKi	=	5.1	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL294459	101008	3	None	-1862	4	Bovine	5.1	pKi	=	5.1	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		14809026	205787	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL83080	205787	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		14809026	205787	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
		CHEMBL83080	205787	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
		10551026	101617	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL298875	101617	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44448067	155529	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		CHEMBL404240	155529	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		2	3261	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
		54562	3261	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
		CHEMBL240773	3261	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
		12050194	202891	1	None	-50	4	Bovine	4.1	pKi	=	4.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	333	5	0	4	3.7	c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL62703	202891	1	None	-50	4	Bovine	4.1	pKi	=	4.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	333	5	0	4	3.7	c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		133633	2241	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
		177	2241	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
		CHEMBL445102	2241	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
		10378389	203245	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL134807	203245	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL64553	203245	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		156020120	178033	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	340	3	0	5	3.4	COc1cc2c3c(c1OC)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4646927	178033	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	340	3	0	5	3.4	COc1cc2c3c(c1OC)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		15654860	203661	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ncccc32)CC1	10.1021/jm00067a009
		CHEMBL67355	203661	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ncccc32)CC1	10.1021/jm00067a009
		45481840	198059	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	267	4	0	2	4.1	CCCCC1c2cc(OC)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		CHEMBL574110	198059	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	267	4	0	2	4.1	CCCCC1c2cc(OC)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		6852376	91599	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		CHEMBL1467585	91599	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		CHEMBL24077	91599	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		CHEMBL503958	91599	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		10588326	158866	0	None	17	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL40950	158866	0	None	17	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
		44436608	146756	0	None	-870	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL392437	146756	0	None	-870	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		167715	2876	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		969	2876	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		CHEMBL225230	2876	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		3033276	13177	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
		CHEMBL1190928	13177	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
		CHEMBL541867	13177	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
		25139331	169928	0	None	-1	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	310	9	2	2	3.9	CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		CHEMBL444128	169928	0	None	-1	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	310	9	2	2	3.9	CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		24823920	97447	0	None	-26	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		CHEMBL270056	97447	0	None	-26	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		53325137	58594	0	None	-37	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684128	58594	0	None	-37	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		10324985	76781	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL199824	76781	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL2068762	76781	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		14659294	167989	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	301	0	2	3	3.5	CN1CCc2cc(Cl)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL431946	167989	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	301	0	2	3	3.5	CN1CCc2cc(Cl)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		70692653	76066	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL2057443	76066	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		70692653	76066	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057443	76066	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		129012255	154378	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)C1Cc3c(c(OC)cc(OC)c3OC)CN1CC2	nan
		CHEMBL3987156	154378	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)C1Cc3c(c(OC)cc(OC)c3OC)CN1CC2	nan
		71454295	84079	0	None	-933	7	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207641	84079	0	None	-933	7	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		57398875	69314	0	None	-213	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	4.7	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928138	69314	0	None	-213	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	4.7	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		71474024	144468	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3906676	144468	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		10551026	101617	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL298875	101617	0	None	-4677	6	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		15691846	204659	0	None	-10	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	335	3	1	3	3.4	O=C1CC(CN2CCC(O)(c3ccccc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		CHEMBL73675	204659	0	None	-10	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	335	3	1	3	3.4	O=C1CC(CN2CCC(O)(c3ccccc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		10672006	46819	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	467	5	1	3	5.5	CCCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		CHEMBL154015	46819	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	467	5	1	3	5.5	CCCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		14198588	171507	2	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		CHEMBL446396	171507	2	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		14198589	63074	2	None	35	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@@H]2c1ccccc1	10.1021/jm00118a012
		CHEMBL1788322	63074	2	None	35	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@@H]2c1ccccc1	10.1021/jm00118a012
		9928332	97180	5	None	-371	9	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayCompound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assay	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/0960-894X(95)00398-D
		CHEMBL268258	97180	5	None	-371	9	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayCompound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assay	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/0960-894X(95)00398-D
		2585	803	103	None	-112	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	803	103	None	-112	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	803	103	None	-112	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	803	103	None	-112	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	803	103	None	-112	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		10665177	23143	0	None	56	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	344	5	2	3	3.8	NCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL133094	23143	0	None	56	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	344	5	2	3	3.8	NCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		10620219	7018	0	None	46	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	386	8	2	3	4.8	CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL108480	7018	0	None	46	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	386	8	2	3	4.8	CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		1353	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		3559	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		86	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		CHEMBL54	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		DB00502	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		45482152	198010	0	None	-131	4	Pig	6.1	pKi	=	6.1	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	517	9	1	8	3.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1	10.1016/j.bmc.2009.06.041
		CHEMBL573792	198010	0	None	-131	4	Pig	6.1	pKi	=	6.1	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	517	9	1	8	3.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1	10.1016/j.bmc.2009.06.041
		4420454	56259	6	None	-41	5	Bovine	6.1	pKi	=	6.1	Binding	Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		CHEMBL162762	56259	6	None	-41	5	Bovine	6.1	pKi	=	6.1	Binding	Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		44400500	166060	0	None	-380	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL425731	166060	0	None	-380	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		10980338	168008	0	None	-2454	4	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1	10.1021/jm015522j
		CHEMBL432059	168008	0	None	-2454	4	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1	10.1021/jm015522j
		10498094	32318	1	None	-5370	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1	10.1021/jm0009989
		CHEMBL141035	32318	1	None	-5370	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1	10.1021/jm0009989
		44412494	78321	0	None	-2630	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	352	4	0	4	3.8	Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL210955	78321	0	None	-2630	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	352	4	0	4	3.8	Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		137643132	158050	0	None	-6309	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1	10.1016/j.bmc.2017.04.036
		CHEMBL4085920	158050	0	None	-6309	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1	10.1016/j.bmc.2017.04.036
		44381146	58507	0	None	-18	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL168372	58507	0	None	-18	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		11639064	189942	0	None	-426	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL458579	189942	0	None	-426	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL517028	189942	0	None	-426	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		156012686	177362	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	352	3	1	4	3.4	COc1cc2c3c(c1OC)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4637673	177362	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	352	3	1	4	3.4	COc1cc2c3c(c1OC)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		118711258	113956	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)cc1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325908	113956	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)cc1	10.1016/j.ejmech.2014.07.059
		10040938	44360	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	308	0	0	5	2.8	Cc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccnc1O2	10.1021/jm00030a011
		CHEMBL151809	44360	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	308	0	0	5	2.8	Cc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccnc1O2	10.1021/jm00030a011
		10044041	48943	0	None	-8	2	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	359	1	0	3	4.3	COc1ccc2c(c1)CC1c3c(ccc(Br)c3CCN1C)O2	10.1021/jm991034o
		CHEMBL156011	48943	0	None	-8	2	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	359	1	0	3	4.3	COc1ccc2c(c1)CC1c3c(ccc(Br)c3CCN1C)O2	10.1021/jm991034o
		1353	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		3559	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		86	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		CHEMBL54	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		DB00502	1911	93	None	-74	83	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		156015018	177571	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	337	2	2	3	4.0	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4640497	177571	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	337	2	2	3	4.0	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		129103318	167314	0	None	-107	14	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		CHEMBL4293999	167314	0	None	-107	14	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		3038495	708	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
		7625	708	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
		CHEMBL25236	708	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
		3038495	708	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
		7625	708	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
		CHEMBL25236	708	37	None	-616	19	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
		3038495	708	37	None	-512	19	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
		7625	708	37	None	-512	19	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
		CHEMBL25236	708	37	None	-512	19	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
		44263882	97225	0	None	-4	3	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL268558	97225	0	None	-4	3	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		25333445	78123	5	None	-380	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL210318	78123	5	None	-380	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		44567596	189783	0	None	-12	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	371	6	3	6	2.2	CN1CCc2cc(OCCOCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		CHEMBL516151	189783	0	None	-12	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	371	6	3	6	2.2	CN1CCc2cc(OCCOCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		126720252	164675	0	None	-269	12	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4216870	164675	0	None	-269	12	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		11222444	130184	0	None	-27	3	Rat	5.1	pKi	=	5.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	369	4	0	5	4.1	CC(C)OCc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		CHEMBL367875	130184	0	None	-27	3	Rat	5.1	pKi	=	5.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	369	4	0	5	4.1	CC(C)OCc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		10873978	168486	0	None	-18620	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		CHEMBL435218	168486	0	None	-18620	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		117774120	132452	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	6	3.3	COC(=O)c1cccnc1Oc1ccc(-c2c(C)n[nH]c(=O)c2C)c(C)c1	nan
		CHEMBL3697592	132452	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	6	3.3	COC(=O)c1cccnc1Oc1ccc(-c2c(C)n[nH]c(=O)c2C)c(C)c1	nan
		26987	949	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	949	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	949	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	949	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	949	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		11631304	73376	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	330	2	1	1	4.6	c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2	10.1021/jm050846j
		CHEMBL201432	73376	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	330	2	1	1	4.6	c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2	10.1021/jm050846j
		71817345	91979	0	None	-158	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		CHEMBL2414992	91979	0	None	-158	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		1588	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		28864	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		43	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		CHEMBL157138	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		DB00589	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		117949705	115197	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	4	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344468	115197	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	4	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		134150400	151980	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	397	7	2	5	4.7	CCCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3966718	151980	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	397	7	2	5	4.7	CCCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		44436618	147923	0	None	-512	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL393365	147923	0	None	-512	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		11581237	138958	0	None	-4897	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	357	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1	10.1021/jm060166w
		CHEMBL378515	138958	0	None	-4897	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	357	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1	10.1021/jm060166w
		137637428	156236	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	250	1	1	5	0.9	CN1CCN(c2ccc(O)c3c2OCCO3)CC1	10.1016/j.bmc.2017.08.037
		CHEMBL4064759	156236	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	250	1	1	5	0.9	CN1CCN(c2ccc(O)c3c2OCCO3)CC1	10.1016/j.bmc.2017.08.037
		72545010	93125	0	None	-229	5	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443003	93125	0	None	-229	5	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1	10.1016/j.bmcl.2013.09.026
		11091738	118092	0	None	-11748	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		CHEMBL340641	118092	0	None	-11748	6	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		11102533	18057	0	None	-27	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	457	8	1	6	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2nc3ccccc3n3cccc23)CC1	10.1021/jm0211220
		CHEMBL126590	18057	0	None	-27	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	457	8	1	6	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2nc3ccccc3n3cccc23)CC1	10.1021/jm0211220
		2274	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44568533	188844	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	280	1	1	3	3.0	COc1cc2c3c(c1)-c1c(N)cccc1C[C@H]3N(C)CC2	10.1016/j.bmc.2008.05.077
		CHEMBL506721	188844	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	280	1	1	3	3.0	COc1cc2c3c(c1)-c1c(N)cccc1C[C@H]3N(C)CC2	10.1016/j.bmc.2008.05.077
		10758744	100507	0	None	11	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL291100	100507	0	None	11	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		162653702	180504	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4753299	180504	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		11699469	77652	0	None	-48	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	537	8	1	5	5.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1	10.1021/jm060138d
		CHEMBL208847	77652	0	None	-48	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	537	8	1	5	5.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1	10.1021/jm060138d
		49783041	17171	0	None	-1949	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	597	7	1	3	6.8	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1256171	17171	0	None	-1949	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	597	7	1	3	6.8	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		10826543	10101	0	None	-85	3	Rat	6.1	pKi	=	6.1	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	1	2	3.7	CCc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL115524	10101	0	None	-85	3	Rat	6.1	pKi	=	6.1	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	1	2	3.7	CCc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		277	1301	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	1301	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	1301	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	1301	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	1301	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		44415382	81107	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	4	1	5	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL215611	81107	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	4	1	5	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		135398745	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		47	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		CHEMBL715	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		DB00334	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		44241718	195264	0	None	-281	4	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	393	4	1	7	1.6	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL551199	195264	0	None	-281	4	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	393	4	1	7	1.6	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		10709445	101363	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115377	101363	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL296993	101363	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		90644064	112036	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	7	0	4	5.0	Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289649	112036	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	7	0	4	5.0	Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		154724609	176599	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4514800	176599	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4597637	176599	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		53325242	57070	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644978	57070	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		15981509	141958	1	None	316	2	Pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
		CHEMBL387250	141958	1	None	316	2	Pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
		130907	194683	5	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		CHEMBL53294	194683	5	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		10448562	115120	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL334350	115120	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		9995986	28269	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL137420	28269	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		10448562	115120	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL334350	115120	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		117773687	132429	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.6	C=C(C)c1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		CHEMBL3697570	132429	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.6	C=C(C)c1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		130442534	166897	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4286177	166897	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		10851849	169933	0	None	16	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL44414	169933	0	None	16	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		13372	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		86764100	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		CHEMBL3697617	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		DB14899	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		13372	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		86764100	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		CHEMBL3697617	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		DB14899	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		9818423	108249	0	None	34	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	281	0	3	3	3.0	Cc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		CHEMBL319707	108249	0	None	34	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	281	0	3	3	3.0	Cc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		15937719	18812	0	None	72	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	249	1	1	2	2.6	C#CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL127843	18812	0	None	72	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	249	1	1	2	2.6	C#CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		11522339	75252	1	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
		CHEMBL203689	75252	1	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
		173871	3614	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
		936	3614	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
		CHEMBL1193571	3614	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
		75201901	166425	19	None	-1	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4277264	166425	19	None	-1	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		11716438	140882	1	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
		CHEMBL382010	140882	1	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
		163091	494	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
		22	494	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
		CHEMBL504548	494	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
		6603797	68018	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL1257041	68018	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL19130	68018	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		44447997	95742	0	None	-20	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	4	0	3	3.9	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1cccc(OC=O)c1-3	10.1021/jm060959i
		CHEMBL258372	95742	0	None	-20	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	4	0	3	3.9	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1cccc(OC=O)c1-3	10.1021/jm060959i
		9888555	165604	16	None	-3235	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		CHEMBL424294	165604	16	None	-3235	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		137651936	157392	0	None	-1000	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4078348	157392	0	None	-1000	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		145990453	166945	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	404	7	2	4	4.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4287062	166945	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	404	7	2	4	4.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2	10.1021/acsmedchemlett.8b00229
		145993377	166968	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	430	8	2	4	4.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4287471	166968	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	430	8	2	4	4.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2	10.1021/acsmedchemlett.8b00229
		70690652	76570	0	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccc(Br)cc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		CHEMBL2062857	76570	0	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccc(Br)cc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		12050202	203298	0	None	-204	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64752	203298	0	None	-204	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		44329067	208006	0	None	-154	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2ccc(C=O)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97319	208006	0	None	-154	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2ccc(C=O)c2C1	10.1016/s0960-894x(01)00564-9
		1240	8823	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL109684	8823	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL1256754	8823	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		44415758	80046	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	521	4	1	5	6.1	CC(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212950	80046	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	521	4	1	5	6.1	CC(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		57391896	69305	0	None	-125	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1013	36	2	15	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928129	69305	0	None	-125	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1013	36	2	15	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		10758745	100433	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115373	100433	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL290438	100433	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10427977	54465	0	None	-660	4	Bovine	6.1	pKi	=	6.1	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	350	3	0	4	3.3	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL160952	54465	0	None	-660	4	Bovine	6.1	pKi	=	6.1	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	350	3	0	4	3.3	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		57395341	69311	0	None	-426	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	2.8	CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928135	69311	0	None	-426	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	2.8	CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		9842468	9909	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		CHEMBL114375	9909	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		9842468	9909	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL114375	9909	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		10088453	66075	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1016/j.bmcl.2004.06.005
		CHEMBL183776	66075	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1016/j.bmcl.2004.06.005
		10088453	66075	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1007/s00044-012-0055-5
		CHEMBL183776	66075	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1007/s00044-012-0055-5
		9972693	168525	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cccnc3Sc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL435441	168525	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cccnc3Sc3ccccc32)CC1	10.1021/jm00030a011
		76321554	106403	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3115574	106403	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3139450	106403	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		14198577	198116	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	0	2	3.9	COc1cc2c(cc1Cl)CCN(C)C2c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL574557	198116	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	0	2	3.9	COc1cc2c(cc1Cl)CCN(C)C2c1ccccc1	10.1016/j.bmc.2009.05.079
		154726353	176323	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4577162	176323	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595382	176323	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		1353	1911	93	None	-38	83	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		3559	1911	93	None	-38	83	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		86	1911	93	None	-38	83	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		CHEMBL54	1911	93	None	-38	83	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		DB00502	1911	93	None	-38	83	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		11500677	140848	1	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		CHEMBL381946	140848	1	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		117773662	132439	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	3.7	CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697580	132439	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	3.7	CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O	nan
		86764101	132477	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		CHEMBL3697618	132477	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		117773616	132414	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.1	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697555	132414	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.1	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		117773980	132432	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	2	6	2.3	Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697573	132432	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	2	6	2.3	Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44393393	123673	0	None	-575	5	Pig	6.1	pKi	=	6.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	537	7	1	4	5.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1	10.1016/j.bmcl.2004.05.052
		CHEMBL362101	123673	0	None	-575	5	Pig	6.1	pKi	=	6.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	537	7	1	4	5.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1	10.1016/j.bmcl.2004.05.052
		9888555	165604	16	None	-3548	8	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm100899z
		CHEMBL424294	165604	16	None	-3548	8	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm100899z
		44340084	9088	0	None	-2238	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL109912	9088	0	None	-2238	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		56597938	3940	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		7651	3940	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL2165126	3940	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		117772974	132428	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	414	4	1	6	3.0	Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697569	132428	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	414	4	1	6	3.0	Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44415648	80170	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213472	80170	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		17755868	143118	1	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	0	1	2	3.8	CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1	10.1021/jm070388+
		CHEMBL389559	143118	1	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	0	1	2	3.8	CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1	10.1021/jm070388+
		44401243	168494	0	None	-34	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL435301	168494	0	None	-34	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		156022132	178217	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	4	1	4	3.6	C=CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4649785	178217	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	4	1	4	3.6	C=CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		10085358	110219	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		CHEMBL323771	110219	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		44448064	94874	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253947	94874	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		44264641	204802	1	None	-11	3	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	230	2	0	4	1.1	CN1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		CHEMBL7505	204802	1	None	-11	3	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	230	2	0	4	1.1	CN1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		44329293	110068	0	None	-75	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL323557	110068	0	None	-75	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		145968810	165038	0	None	-120	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		CHEMBL4226226	165038	0	None	-120	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		154725813	176526	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4568916	176526	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4597047	176526	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		127031404	138802	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	4	2	5	3.2	COc1cc2c(cc1O)C(C)N(Cc1cccc(O)c1OC)CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780975	138802	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	4	2	5	3.2	COc1cc2c(cc1O)C(C)N(Cc1cccc(O)c1OC)CC2	10.1016/j.bmc.2016.03.037
		136043856	80107	0	None	-4	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	438	2	1	4	5.6	Fc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(F)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL213200	80107	0	None	-4	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	438	2	1	4	5.6	Fc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(F)c1	10.1016/j.bmcl.2006.06.034
		71062708	154306	0	None	-47	12	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3986651	154306	0	None	-47	12	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		90644060	112031	0	None	-64	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	358	4	0	2	4.4	Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmc.2014.04.026
		CHEMBL3289644	112031	0	None	-64	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	358	4	0	2	4.4	Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmc.2014.04.026
		103	4153	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		2875	4153	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		5736	4153	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		CHEMBL285802	4153	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		DB09225	4153	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		1248739	140086	16	None	-190	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	310	3	0	4	2.8	Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL380054	140086	16	None	-190	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	310	3	0	4	2.8	Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		44339984	167797	0	None	-186	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL430522	167797	0	None	-186	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		135524323	195426	0	None	-3467	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	382	5	2	6	1.6	COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL552268	195426	0	None	-3467	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	382	5	2	6	1.6	COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1	10.1016/j.bmc.2009.05.015
		45272537	196526	0	None	-588	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL563614	196526	0	None	-588	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		135398745	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		47	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		CHEMBL715	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		DB00334	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		44415804	81475	0	None	147	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL215997	81475	0	None	147	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		135398745	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		47	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		CHEMBL715	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		DB00334	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		135398745	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		47	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		CHEMBL715	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		DB00334	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		135398745	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		47	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		CHEMBL715	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		DB00334	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		135398745	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		47	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		CHEMBL715	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		DB00334	2914	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		15627811	194932	1	None	-8	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL54183	194932	1	None	-8	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		44405980	72056	0	None	-23	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		CHEMBL197656	72056	0	None	-23	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		1588	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	2325	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		44415606	80116	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL213239	80116	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		44415823	141457	0	None	331	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccncc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL384248	141457	0	None	331	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccncc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415473	79922	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	437	1	1	5	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212486	79922	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	437	1	1	5	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		118709177	113425	0	None	-16	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1135	31	0	14	12.5	O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318850	113425	0	None	-16	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1135	31	0	14	12.5	O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		86764213	132450	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	1	5	4.2	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697590	132450	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	1	5	4.2	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		15711850	13239	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1191350	13239	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL542436	13239	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		117949627	115156	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	287	1	1	4	3.1	COc1cc2c(cc1O)[C@@H]1Cc3sccc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344356	115156	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	287	1	1	4	3.1	COc1cc2c(cc1O)[C@@H]1Cc3sccc3CN1CC2	10.1016/j.bmc.2014.09.024
		44436621	91031	0	None	-151	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL239733	91031	0	None	-151	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		71456045	84073	0	None	-1202	6	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207635	84073	0	None	-1202	6	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		127046952	140101	0	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	421	12	3	5	4.5	COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800636	140101	0	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	421	12	3	5	4.5	COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		25093832	155880	0	None	-2290	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4060461	155880	0	None	-2290	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		137640391	156705	0	None	-1096	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4070091	156705	0	None	-1096	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		137635364	156260	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4064974	156260	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4074669	156260	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		10314824	35380	1	None	-8511	5	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL143761	35380	1	None	-8511	5	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm0009989
		10314824	35380	1	None	-8511	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm060166w
		CHEMBL143761	35380	1	None	-8511	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm060166w
		44448060	155244	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		CHEMBL402735	155244	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		137657153	159557	0	None	-776	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4102616	159557	0	None	-776	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		85658088	165003	0	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4225830	165003	0	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		1043	1582	14	None	-9549	28	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	1582	14	None	-9549	28	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	1582	14	None	-9549	28	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	1582	14	None	-9549	28	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	1582	14	None	-9549	28	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		135986088	178115	0	None	-263	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
		CHEMBL464811	178115	0	None	-263	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
		76321554	106403	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3115574	106403	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3139450	106403	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		112500029	132466	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	0	6	3.9	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697606	132466	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	0	6	3.9	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C	nan
		14198596	101643	0	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	101643	0	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		14198597	102124	1	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL302393	102124	1	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00129a006
		117772840	132436	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	343	3	1	5	2.9	Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697577	132436	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	343	3	1	5	2.9	Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		44320129	167894	0	None	-1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL431220	167894	0	None	-1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		16105548	82698	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
		CHEMBL217964	82698	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
		CHEMBL221652	82698	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
		53363200	63853	0	None	-134	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	509	14	0	9	3.7	CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803052	63853	0	None	-134	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	509	14	0	9	3.7	CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		11682812	78209	0	None	-5495	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	402	5	0	7	3.2	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1	10.1021/jm060166w
		CHEMBL210551	78209	0	None	-5495	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	402	5	0	7	3.2	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1	10.1021/jm060166w
		2	3261	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
		54562	3261	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
		CHEMBL240773	3261	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
		2	3261	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
		54562	3261	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
		CHEMBL240773	3261	23	None	-977	29	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
		44380716	59087	0	None	-12	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL169631	59087	0	None	-12	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		2	3261	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
		54562	3261	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
		CHEMBL240773	3261	23	None	-16595	29	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
		2	3261	23	None	-977	29	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
		54562	3261	23	None	-977	29	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
		CHEMBL240773	3261	23	None	-977	29	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
		44582179	181425	0	None	-57	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	379	6	0	5	2.5	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476393	181425	0	None	-57	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	379	6	0	5	2.5	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2009.01.067
		154706431	176585	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4531363	176585	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597531	176585	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		1220	187	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		31	187	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		7	187	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		CHEMBL56	187	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		44591012	175580	0	None	-177	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL457957	175580	0	None	-177	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		44386883	60400	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	328	3	1	4	3.2	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CNCC2	10.1016/s0960-894x(98)00138-3
		CHEMBL174949	60400	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	328	3	1	4	3.2	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CNCC2	10.1016/s0960-894x(98)00138-3
		44415845	80013	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	511	3	1	7	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3-n3ccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212844	80013	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	511	3	1	7	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3-n3ccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11515697	178232	0	None	-11	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL458397	178232	0	None	-11	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL465054	178232	0	None	-11	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		86767093	129423	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		CHEMBL3671280	129423	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		10574176	9962	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	420	5	1	3	5.3	CN(C)c1ccc(CCN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		CHEMBL114726	9962	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	420	5	1	3	5.3	CN(C)c1ccc(CCN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		44320026	206099	0	None	3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL85689	206099	0	None	3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		117774323	132420	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.9	Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697561	132420	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.9	Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		10643780	119395	0	None	-97	4	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1	10.1021/jm0009989
		CHEMBL344602	119395	0	None	-97	4	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1	10.1021/jm0009989
		10276451	200285	37	None	-12022	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
		CHEMBL2112910	200285	37	None	-12022	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
		CHEMBL59725	200285	37	None	-12022	10	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
		10276451	200285	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
		CHEMBL2112910	200285	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
		CHEMBL59725	200285	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
		10276451	200285	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
		CHEMBL2112910	200285	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
		CHEMBL59725	200285	37	None	-32359	10	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
		137632607	156339	0	None	-2344	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	305	3	2	5	1.6	CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1	10.1016/j.bmc.2017.08.037
		CHEMBL4065797	156339	0	None	-2344	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	305	3	2	5	1.6	CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1	10.1016/j.bmc.2017.08.037
		44278298	99164	0	None	-2884	3	Rat	4.1	pKi	=	4.1	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	348	4	0	2	4.3	O=C(c1cccc(CN2CCC(c3ccccc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		CHEMBL281214	99164	0	None	-2884	3	Rat	4.1	pKi	=	4.1	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	348	4	0	2	4.3	O=C(c1cccc(CN2CCC(c3ccccc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		44304652	200322	0	None	-28	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL59749	200322	0	None	-28	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		44415622	138603	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	591	4	1	5	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc(F)cc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL377564	138603	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	591	4	1	5	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc(F)cc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		228	445	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		33	445	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		6005	445	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		CHEMBL53	445	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		DB00714	445	28	None	-30	24	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		180	401	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		200	401	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		2160	401	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		CHEMBL629	401	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		DB00321	401	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		135398737	958	93	None	-44	89	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		38	958	93	None	-44	89	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		722	958	93	None	-44	89	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		CHEMBL42	958	93	None	-44	89	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		DB00363	958	93	None	-44	89	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		44276652	99494	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		CHEMBL283247	99494	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		127045855	139664	0	None	-9	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		CHEMBL3797876	139664	0	None	-9	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		44381276	58728	0	None	-2	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL168541	58728	0	None	-2	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		44304644	203251	0	None	-8	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	454	8	2	4	4.5	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1	10.1016/s0960-894x(00)00405-4
		CHEMBL64566	203251	0	None	-8	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	454	8	2	4	4.5	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1	10.1016/s0960-894x(00)00405-4
		154703922	176289	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4590211	176289	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4595146	176289	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		154703824	176626	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4456007	176626	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4597876	176626	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		181743	178572	5	None	-446	22	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH233930 from human dopamine D1 receptorDisplacement of [3H]SCH233930 from human dopamine D1 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	178572	5	None	-446	22	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH233930 from human dopamine D1 receptorDisplacement of [3H]SCH233930 from human dopamine D1 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		242	470	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		34	470	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		60795	470	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL1112	470	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		DB01238	470	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		44304621	203419	0	None	-74	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL65641	203419	0	None	-74	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		6101909	100936	1	None	1	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		CHEMBL294012	100936	1	None	1	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		6101909	100936	1	None	-1	3	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		CHEMBL294012	100936	1	None	-1	3	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		44455426	155149	0	None	-12	12	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL402143	155149	0	None	-12	12	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		44415629	80030	0	None	338	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccsc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212896	80030	0	None	338	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccsc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		10107367	102434	1	None	-7	4	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL303993	102434	1	None	-7	4	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		44385980	61384	0	None	3	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	268	1	1	2	3.2	Fc1ccc(N2CC3CNCCc4cccc2c43)cc1	10.1016/s0960-894x(98)00138-3
		CHEMBL176990	61384	0	None	3	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	268	1	1	2	3.2	Fc1ccc(N2CC3CNCCc4cccc2c43)cc1	10.1016/s0960-894x(98)00138-3
		11558247	75422	0	None	2	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
		CHEMBL204098	75422	0	None	2	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
		86764211	132446	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697587	132446	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		11573806	75416	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
		CHEMBL204065	75416	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
		2865	4143	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		59	4143	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		60854	4143	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		CHEMBL708	4143	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		DB00246	4143	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		1353	1911	93	None	-30	83	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		3559	1911	93	None	-30	83	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		86	1911	93	None	-30	83	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		CHEMBL54	1911	93	None	-30	83	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		DB00502	1911	93	None	-30	83	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		10830233	202853	0	None	8	2	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	329	0	2	1	4.3	CN1CCc2c([nH]c3ccccc23)Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		CHEMBL62529	202853	0	None	8	2	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	329	0	2	1	4.3	CN1CCc2c([nH]c3ccccc23)Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		117774170	132435	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	385	3	1	4	4.3	Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697576	132435	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	385	3	1	4	4.3	Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		134137323	142967	0	None	33	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	4	2	5	4.7	CCC(C)Oc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3894329	142967	0	None	33	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	4	2	5	4.7	CCC(C)Oc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		74223724	129417	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671274	129417	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		74223777	129435	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	350	3	1	4	5.1	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1Cl	nan
		CHEMBL3671291	129435	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	350	3	1	4	5.1	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1Cl	nan
		44393403	65078	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		CHEMBL182379	65078	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		137655735	158992	0	None	-1230	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4096353	158992	0	None	-1230	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		52943802	17618	0	None	-199	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	363	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		CHEMBL1258270	17618	0	None	-199	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	363	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		44319368	106064	0	None	-7	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		CHEMBL313320	106064	0	None	-7	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		10807793	202979	1	None	7	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	350	2	1	3	3.8	COc1cc2c(cc1OC)Cc1[nH]c3ccccc3c1CCN(C)CC2	10.1021/jm9911478
		CHEMBL63063	202979	1	None	7	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	350	2	1	3	3.8	COc1cc2c(cc1OC)Cc1[nH]c3ccccc3c1CCN(C)CC2	10.1021/jm9911478
		164627027	186427	0	None	-45	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	466	5	3	4	4.3	O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1	10.1016/j.bmcl.2021.128047
		CHEMBL4876260	186427	0	None	-45	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	466	5	3	4	4.3	O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1	10.1016/j.bmcl.2021.128047
		44403224	71915	0	None	-102	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1	10.1016/j.bmcl.2005.07.037
		CHEMBL197195	71915	0	None	-102	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1	10.1016/j.bmcl.2005.07.037
		44436605	149063	0	None	-2951	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL394292	149063	0	None	-2951	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		53318564	58595	0	None	-8	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	646	14	0	7	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCN(CCCN2CCN(c4ccccc4OC)CC2)S(C)(=O)=O)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684129	58595	0	None	-8	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	646	14	0	7	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCN(CCCN2CCN(c4ccccc4OC)CC2)S(C)(=O)=O)c1-3	10.1016/j.bmc.2011.01.053
		57390119	69303	0	None	-218	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	969	33	2	14	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928127	69303	0	None	-218	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	969	33	2	14	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		44381286	120367	0	None	-4	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL353220	120367	0	None	-4	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		118711263	113958	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1ccccc1-c1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		CHEMBL3325914	113958	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1ccccc1-c1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		10432606	204514	0	None	-11	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	426	7	0	4	4.0	O=C(CCCN1CCN(CC2CC(=O)c3ccc(F)cc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		CHEMBL72649	204514	0	None	-11	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	426	7	0	4	4.0	O=C(CCCN1CCN(CC2CC(=O)c3ccc(F)cc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		10402195	41526	1	None	1	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3Oc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL149108	41526	1	None	1	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3Oc3ccccc32)CC1	10.1021/jm00030a011
		6603798	100180	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL1613539	100180	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL288096	100180	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		117773861	132416	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2ncc(Cl)cc2C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697557	132416	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2ncc(Cl)cc2C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44403213	71787	4	None	-1737	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	423	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		CHEMBL196744	71787	4	None	-1737	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	423	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		54581964	61608	0	None	-3162	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	489	8	0	5	5.4	COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771111	61608	0	None	-3162	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	489	8	0	5	5.4	COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		6603798	100180	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL1613539	100180	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL288096	100180	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		137659303	159304	0	None	-154	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4099711	159304	0	None	-154	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		118709163	113409	0	None	-338	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	888	21	0	8	11.3	O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318835	113409	0	None	-338	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	888	21	0	8	11.3	O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		12050196	203118	6	None	-15	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	349	5	0	4	4.1	c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL64043	203118	6	None	-15	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	349	5	0	4	4.1	c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		71462090	84593	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
		CHEMBL2158640	84593	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
		CHEMBL2221044	84593	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
		24949535	181559	0	None	-1122	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		CHEMBL476722	181559	0	None	-1122	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		177511	101542	23	None	-14	2	Rat	5.0	pKi	=	5.0	Binding	The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.	ChEMBL	255	2	3	3	2.5	Oc1cc2c(cc1O)C(Cc1ccccc1)NCC2	10.1016/s0960-894x(00)00326-7
		CHEMBL298285	101542	23	None	-14	2	Rat	5.0	pKi	=	5.0	Binding	The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.	ChEMBL	255	2	3	3	2.5	Oc1cc2c(cc1O)C(Cc1ccccc1)NCC2	10.1016/s0960-894x(00)00326-7
		156013773	177273	0	None	-9	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	280	1	0	3	3.3	CN1CCc2cccc3c2C1Cc1ccc([N+](=O)[O-])cc1-3	10.1016/j.bmcl.2020.127053
		CHEMBL4636242	177273	0	None	-9	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	280	1	0	3	3.3	CN1CCc2cccc3c2C1Cc1ccc([N+](=O)[O-])cc1-3	10.1016/j.bmcl.2020.127053
		1353	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		3559	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		86	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		CHEMBL54	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		DB00502	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		1353	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		3559	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		86	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		CHEMBL54	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		DB00502	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		74223773	129424	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)nc[n+]([O-])c1C	nan
		CHEMBL3671281	129424	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)nc[n+]([O-])c1C	nan
		154725276	176290	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4456964	176290	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595147	176290	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		25071692	111789	0	None	-2187	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287405	111789	0	None	-2187	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		118709169	113416	0	None	-6	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1029	31	0	8	15.2	O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318841	113416	0	None	-6	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1029	31	0	8	15.2	O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		44372009	48839	0	None	-123	4	Bovine	6.0	pKi	=	6.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	402	4	0	4	5.0	Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL155913	48839	0	None	-123	4	Bovine	6.0	pKi	=	6.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	402	4	0	4	5.0	Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		42626103	56253	0	None	-2137	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		CHEMBL1627323	56253	0	None	-2137	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		44241577	14014	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197140	14014	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL560721	14014	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		117773063	132443	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	4	1	5	4.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697584	132443	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	4	1	5	4.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		154725001	176647	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4525624	176647	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4598002	176647	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		44344506	13828	0	None	-8	2	Rat	5.0	pKi	=	5.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	327	1	1	2	4.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(-c2ccccc2)c(O)c1-3	10.1021/jm960188q
		CHEMBL119577	13828	0	None	-8	2	Rat	5.0	pKi	=	5.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	327	1	1	2	4.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(-c2ccccc2)c(O)c1-3	10.1021/jm960188q
		CHEMBL4802048	214061	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
		25139479	184317	0	None	-1071	4	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
		CHEMBL484202	184317	0	None	-1071	4	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
		45483655	198115	0	None	-138	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1	10.1021/jm901120h
		CHEMBL574534	198115	0	None	-138	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1	10.1021/jm901120h
		71110301	92198	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425371	92198	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL4802048	214061	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
		2726	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		621	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		83	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		CHEMBL71	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		DB00477	919	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		127047859	140051	0	None	-338	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	476	12	3	6	4.1	COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800341	140051	0	None	-338	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	476	12	3	6	4.1	COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		45481877	198129	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	10	2	10	3.6	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5ncccn5)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		CHEMBL574627	198129	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	10	2	10	3.6	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5ncccn5)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		3082625	194728	8	None	-199	4	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2007.05.057
		CHEMBL53510	194728	8	None	-199	4	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2007.05.057
		154705128	176291	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4454872	176291	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595148	176291	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		100	3805	58	None	-47	55	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	3805	58	None	-47	55	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	3805	58	None	-47	55	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	3805	58	None	-47	55	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	3805	58	None	-47	55	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		86767094	129426	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cncc2nccn12	nan
		CHEMBL3671283	129426	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cncc2nccn12	nan
		1353	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		3559	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		86	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		CHEMBL54	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		DB00502	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		1353	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		3559	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		86	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		CHEMBL54	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		DB00502	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		1353	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		3559	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		86	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		CHEMBL54	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		DB00502	1911	93	None	-74	83	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		10454026	17907	0	None	-3019	9	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		CHEMBL125916	17907	0	None	-3019	9	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		10058098	198607	9	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligandCompound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand	ChEMBL	179	0	3	3	0.8	Oc1cc2c(cc1O)CCNCC2	10.1021/jm00160a018
		CHEMBL57873	198607	9	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligandCompound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand	ChEMBL	179	0	3	3	0.8	Oc1cc2c(cc1O)CCNCC2	10.1021/jm00160a018
		11678172	78032	0	None	-2137	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		CHEMBL209876	78032	0	None	-2137	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		25071384	111781	0	None	-251	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287397	111781	0	None	-251	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		44381118	57569	0	None	-426	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL166587	57569	0	None	-426	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		44319102	206141	0	None	-16	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL86060	206141	0	None	-16	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		44582187	181570	0	None	-47	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	8	0	4	3.7	COc1ccccc1N1CCN(CCCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476808	181570	0	None	-47	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	8	0	4	3.7	COc1ccccc1N1CCN(CCCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		44323870	111591	0	None	3	4	Rat	7.0	pKi	=	7.0	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL328246	111591	0	None	3	4	Rat	7.0	pKi	=	7.0	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		25142456	82406	2	None	-48	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		CHEMBL217299	82406	2	None	-48	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		44415685	80167	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	551	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213466	80167	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	551	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415450	139623	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	425	1	1	5	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(C)(C)C)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL379757	139623	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	425	1	1	5	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(C)(C)C)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		1353	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		3559	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		86	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		CHEMBL54	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		DB00502	1911	93	None	-30	83	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		118445551	167315	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
		CHEMBL4294009	167315	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
		53363201	63855	0	None	-114	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	893	27	0	15	7.0	COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803054	63855	0	None	-114	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	893	27	0	15	7.0	COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		71722297	102472	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397382	102472	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040156	102472	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		49782601	17488	0	None	-602	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	487	6	1	3	6.2	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1257810	17488	0	None	-602	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	487	6	1	3	6.2	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		10561522	36201	0	None	-51	2	Bovine	4.0	pKi	=	4.0	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2c(C)cccc2C)C1	10.1021/jm9708700
		CHEMBL144501	36201	0	None	-51	2	Bovine	4.0	pKi	=	4.0	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2c(C)cccc2C)C1	10.1021/jm9708700
		154705520	176260	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4452683	176260	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4594959	176260	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		2750	204061	76	None	-5	12	Human	5.0	pKi	=	5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	204061	76	None	-5	12	Human	5.0	pKi	=	5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		15115519	207207	0	None	-151	2	Human	7.0	pKi	=	7	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	677	12	1	10	6.4	O=C(CCCN1CCC2(CC1)C(=O)N(CCc1ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc1)CN2c1ccccc1)c1ccc(F)cc1	10.1021/jm00115a012
		CHEMBL92649	207207	0	None	-151	2	Human	7.0	pKi	=	7	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	677	12	1	10	6.4	O=C(CCCN1CCC2(CC1)C(=O)N(CCc1ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc1)CN2c1ccccc1)c1ccc(F)cc1	10.1021/jm00115a012
		44415605	80115	0	None	11	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213238	80115	0	None	11	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		42625205	56254	0	None	-89	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		CHEMBL1627324	56254	0	None	-89	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		3303	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
		5311200	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
		CHEMBL267014	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
		3303	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
		5311200	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
		CHEMBL267014	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
		24824066	157380	0	None	-2	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		CHEMBL407818	157380	0	None	-2	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		3303	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
		5311200	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
		CHEMBL267014	2244	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
		154706703	176232	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4550187	176232	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4594691	176232	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		154725749	176688	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4453478	176688	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4598388	176688	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		240	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	None	-	24	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		3294	2006	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-	45	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2601	3780	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		100	3805	58	None	-16	55	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	None	-16	55	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	None	-16	55	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	None	-16	55	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	None	-16	55	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5281878	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	None	-11	17	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1028	291	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		1960	2857	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		439260	2857	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		505	2857	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL1437	2857	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00368	2857	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		1153	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	1628	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		2869	4152	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		60	4152	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		60857	4152	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		CHEMBL1185	4152	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		DB00315	4152	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		5018	3549	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		943	3549	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		946	3549	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		CHEMBL13668	3549	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	2	28	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		None	216384	0	3H-SCH23390	5495	2	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	329	1	1	3	3.6	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)Cl	None
		None	216382	0	3H-SCH23390	165	2	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	327	1	1	3	4.4	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OC=C4)O)Cl	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		1242	3613	27	3H-SCH23390	1	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	1	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	1	18	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1243	3618	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
		944	3618	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
		CHEMBL324017	3618	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
		5281878	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281878	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-4	17	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-11	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		25058166	215960	0	3H-SCH23390 High	-6	27	Bovine	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390 High	-6	27	Bovine	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		3036864	202754	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-26	28	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-3	28	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		5018	3549	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		5018	3549	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	3549	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	3549	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	3549	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	3549	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	3549	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	3549	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		37459	746	13	3H-SCH23390	-2	25	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		37459	746	13	3H-SCH23390	-8	25	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-2	25	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-8	25	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-2	25	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-8	25	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		133538	3619	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
		8443	3619	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
		CHEMBL574558	3619	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
		3036864	202754	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-3	28	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	202754	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-2	28	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		1218	3616	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		938	3616	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		CHEMBL353335	3616	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		None	216386	0	3H-SCH23390	436	2	Mouse	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	349	1	2	3	3.3	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O.Br	None
		277	1301	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		135398745	2914	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		6603820	95774	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		1241	100179	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL288090	100179	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL552611	100179	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		135398745	2914	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		100	3805	58	3H-SCH23390	-47	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-SCH23390	-47	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-SCH23390	-47	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-SCH23390	-47	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-SCH23390	-47	55	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		202	1508	77	UNDEFINED	-9	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	1508	77	UNDEFINED	-9	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	1508	77	UNDEFINED	-9	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	1508	77	UNDEFINED	-9	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	1508	77	UNDEFINED	-9	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		2	3261	23	3H-SCH23390	-208	29	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-SCH23390	-208	29	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-SCH23390	-208	29	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		121881	3490	27	3H-SCH23390	-19952	14	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		256	3490	27	3H-SCH23390	-19952	14	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		CHEMBL68131	3490	27	3H-SCH23390	-19952	14	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		46222048	8984	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
		CHEMBL1098230	8984	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
		18922713	98498	0	3H-SCH23390	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		CHEMBL276031	98498	0	3H-SCH23390	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		24840389	115213	4	3H-SCH23390	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		CHEMBL334529	115213	4	3H-SCH23390	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		44591098	176762	0	UNDEFINED	-288	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL460402	176762	0	UNDEFINED	-288	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
		12016890	190776	6	3H-SCH23390	-1698	11	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		CHEMBL5183389	190776	6	3H-SCH23390	-1698	11	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		5656	203066	87	UNDEFINED	-25	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	UNDEFINED	-25	40	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	203127	52	UNDEFINED	-1	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	203127	52	UNDEFINED	-1	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		None	215992	0	3H-SCH23390	-107	11	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
		104911	216019	0	3H-SCH23390	-4168	37	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		3075702	217332	0	3H-SCH23390	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		1574	81	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	81	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	81	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		5	139	72	3H-SCH23390 Low	-23442	54	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	139	72	3H-SCH23390	-16595	54	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-SCH23390 Low	-23442	54	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-SCH23390	-16595	54	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-SCH23390 Low	-23442	54	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-SCH23390	-16595	54	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-SCH23390 Low	-23442	54	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-SCH23390	-16595	54	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1192	147	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1794	147	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		CHEMBL501701	147	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1220	187	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	187	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	187	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	187	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		3153	297	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	297	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	297	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		179	400	115	3H-SCH23390	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		179	400	115	3H-SCH23390	-4365	49	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-SCH23390	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	400	115	3H-SCH23390	-4365	49	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-SCH23390	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	400	115	3H-SCH23390	-4365	49	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-SCH23390	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	400	115	3H-SCH23390	-4365	49	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-SCH23390	-4365	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	400	115	3H-SCH23390	-4365	49	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2554	796	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		489	796	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		5339	796	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		CHEMBL108	796	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		DB00564	796	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		2147	1401	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		5826	1401	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		841	1401	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		CHEMBL612	1401	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		DB01576	1401	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		3016	1412	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		3364	1412	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		852	1412	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		CHEMBL12	1412	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		DB00829	1412	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		3151	1462	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	1462	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	1462	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	1462	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	1462	97	3H-SCH23390	-12882	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		681	1465	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		681	1465	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390 Low	-23	39	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390	-97	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1209	1658	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	1658	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	1658	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	1658	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	1658	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1067	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		119	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		1262	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		5410	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		6992099	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		CHEMBL96	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		DB02530	1709	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		119376	1841	48	3H-SCH23390	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	1841	48	3H-SCH23390	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	1841	48	3H-SCH23390	-43651	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		1204	1932	119	3H-SCH23390	-1949	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	1932	119	3H-SCH23390	-1949	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	1932	119	3H-SCH23390	-1949	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	1932	119	3H-SCH23390	-1949	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	1932	119	3H-SCH23390	-1949	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	1932	119	3H-SCH23390	-1949	24	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		12575	1988	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	1988	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	1988	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1427	2013	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1427	2013	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1310	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		1369	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		33032	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		44272391	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		88747398	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		CHEMBL575060	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		DB00142	2315	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		18971832	2418	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		21	2418	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		CHEMBL3186179	2418	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		119192	2481	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		1582	2481	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		CHEMBL506981	2481	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		DB06455	2481	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		1605	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		1728	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		22267	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		4095	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		4586	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		5458	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		CHEMBL159659	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		CHEMBL651	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		DB00333	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		DB13515	2498	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		134	2514	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1782	2518	84	3H-SCH23390	-676	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	2518	84	3H-SCH23390	-676	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	2518	84	3H-SCH23390	-676	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	2518	84	3H-SCH23390	-676	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	2518	84	3H-SCH23390	-676	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		1830	2590	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1830	2590	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1638	2724	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		1676	2724	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		1878	2724	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		5284596	2724	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		CHEMBL80	2724	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		DB01183	2724	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		484	2858	51	3H-SCH23390	-54	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		484	2858	51	3H-SCH23390	-24	35	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-SCH23390	-54	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-SCH23390	-24	35	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-SCH23390	-54	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-SCH23390	-24	35	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		15897	2862	0	3H-SCH23390	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	2862	0	3H-SCH23390	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	2862	0	3H-SCH23390	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		163839	2955	0	3H-SCH23390	-562	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		268	2955	0	3H-SCH23390	-562	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		CHEMBL55171	2955	0	3H-SCH23390	-562	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		2136	3095	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		4768	3095	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		7268	3095	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		CHEMBL753	3095	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		DB00925	3095	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		2142	3096	58	3H-SCH23390	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	3096	58	3H-dopamine	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	3096	58	3H-SCH23390	-3801	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-SCH23390	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-dopamine	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	3096	58	3H-SCH23390	-3801	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-SCH23390	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-dopamine	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	3096	58	3H-SCH23390	-3801	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-SCH23390	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-dopamine	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	3096	58	3H-SCH23390	-3801	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-SCH23390	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-dopamine	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	3096	58	3H-SCH23390	-3801	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-SCH23390	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-dopamine	-3801	36	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	3096	58	3H-SCH23390	-3801	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		16362	3125	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-SCH23390	-52480	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2202	3132	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	3132	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	3132	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	3132	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	3132	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		119570	3159	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		119570	3159	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	3159	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	3159	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	3159	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	3H-SCH23390	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	3159	96	UNDEFINED	-7585	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2286	3183	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2303	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4946	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		564	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		63	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		91536	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL27	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL452861	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		DB00571	3187	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		243	3202	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	3202	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	3202	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	3202	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	3202	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		2	3261	23	3H-SCH23390 Low	-2089	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		2	3261	23	3H-SCH23390	-977	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-SCH23390 Low	-2089	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	3261	23	3H-SCH23390	-977	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-SCH23390 Low	-2089	29	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	3261	23	3H-SCH23390	-977	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		173	3262	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	3262	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	3262	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		3033769	3281	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3033769	3281	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	3281	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	3281	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	3281	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	3281	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	3281	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	3281	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	3281	61	3H-SCH23390	-2754	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	3281	61	3H-SCH23390	-2754	19	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		2389	3331	118	3H-SCH23390	-346	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-346	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-346	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-346	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-346	67	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2402	3370	62	3H-SCH23390	-74	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	3H-SCH23390	-74	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	3H-SCH23390	-74	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	3H-SCH23390	-74	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	3H-SCH23390	-74	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		183782	3398	20	3H-SCH23390	-1737	13	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		237	3398	20	3H-SCH23390	-1737	13	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL85251	3398	20	3H-SCH23390	-1737	13	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		128563	3464	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	3464	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	3464	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	3464	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		221	3491	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	3491	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	3491	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		1577	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1577	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1577	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1577	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-SCH23390	-70	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-SCH23390	-549	21	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	3H-SCH23390	-549	21	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1267	3804	49	3H-dopamine	-4168	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	3804	49	3H-dopamine	-4168	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	3804	49	3H-dopamine	-4168	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		102	4127	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	4127	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	4127	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	4127	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	4127	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		6047	4323	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O	None
		6971033	4323	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O	None
		CHEMBL1009	4323	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O	None
		19493	11255	65	3H-SCH23390	-2344	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
		CHEMBL1179	11255	65	3H-SCH23390	-2344	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
		CHEMBL1255743	11255	65	3H-SCH23390	-2344	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
		2662	11384	131	3H-SCH23390	-3	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	3H-SCH23390	-3	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		10836	14467	14	3H-SCH23390	-147	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	14467	14	3H-SCH23390	-147	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		5090	15561	106	3H-SCH23390	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	3H-SCH23390	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		671690	27097	35	3H-SCH23390	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	27097	35	3H-SCH23390	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		10297	27112	30	3H-SCH23390	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	27112	30	3H-SCH23390	-38	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	46800	99	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	46800	99	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	46800	99	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		53321123	58548	0	UNDEFINED	-181	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	0	2	4.2	C#CCOc1cccc2c1-c1cccc3c1C(C2)N(CCC)CC3	None
		CHEMBL1684022	58548	0	UNDEFINED	-181	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	0	2	4.2	C#CCOc1cccc2c1-c1cccc3c1C(C2)N(CCC)CC3	None
		10624	70300	19	3H-SCH23390	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	70300	19	3H-SCH23390	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	70300	19	3H-SCH23390	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		14659268	79638	2	UNDEFINED	-134	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	None
		CHEMBL2115032	79638	2	UNDEFINED	-134	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	None
		108107	79944	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		156592250	79944	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL1256878	79944	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL212579	79944	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		442108	84636	6	3H-SCH23390	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		CHEMBL222287	84636	6	3H-SCH23390	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		54477	84653	36	3H-SCH23390	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		54477	84653	36	UNDEFINED	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	3H-SCH23390	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	84653	36	UNDEFINED	-138	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		21830793	91835	10	3H-8-OH-DPAT	-66069	45	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	91835	10	3H-8-OH-DPAT	-66069	45	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		2244	94233	100	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	94233	100	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		44448057	94818	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	1	1	2	3.5	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		CHEMBL253529	94818	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	1	1	2	3.5	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		44448062	94848	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		CHEMBL253737	94848	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		44448066	94875	0	UNDEFINED	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	None
		CHEMBL253948	94875	0	UNDEFINED	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	None
		44448068	94876	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	4	0	3	5.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(Cc1ccccc1)CC2	None
		CHEMBL253949	94876	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	4	0	3	5.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(Cc1ccccc1)CC2	None
		4528	98126	80	3H-SCH23390	-120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		4528	98126	80	3H-SCH23390	-120	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	98126	80	3H-SCH23390	-120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	98126	80	3H-SCH23390	-120	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		104870	98880	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	98880	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	98880	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		3025067	99382	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		65853	99382	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		CHEMBL282614	99382	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		3663	99967	83	3H-SCH23390	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	99967	83	3H-SCH23390	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		127708	112521	7	UNDEFINED	-251	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	112521	7	UNDEFINED	-251	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		3452843	119525	15	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		CHEMBL345686	119525	15	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		446220	133521	14	3H-SCH23390	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	133521	14	3H-SCH23390	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		44208932	140707	7	UNDEFINED	-89125	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	140707	7	UNDEFINED	-89125	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		9669	153188	2	3H-dopamine	-3890	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	2	1	2	3.9	CC(C)=CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@@H]1[C@H]2C	None
		CHEMBL397705	153188	2	3H-dopamine	-3890	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	2	1	2	3.9	CC(C)=CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@@H]1[C@H]2C	None
		44448058	155204	0	UNDEFINED	2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		CHEMBL402517	155204	0	UNDEFINED	2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		44448065	155480	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		CHEMBL404037	155480	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		44448069	155530	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	337	4	0	3	4.2	CCCN1CCc2cc(OC)c(OC)c3c2C1Cc1ccccc1C3	None
		CHEMBL404241	155530	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	337	4	0	3	4.2	CCCN1CCc2cc(OC)c(OC)c3c2C1Cc1ccccc1C3	None
		1615	167791	24	3H-SCH23390	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	167791	24	3H-SCH23390	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		4595	176715	106	3H-dopamine	-186	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	176715	106	3H-dopamine	-186	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		44581146	176828	0	UNDEFINED	-354	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.5	COc1cccc2cc3n(c12)CCN(CCCCNC(=O)C1=Cc2ccccc2CN1)C3	None
		CHEMBL461023	176828	0	UNDEFINED	-354	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.5	COc1cccc2cc3n(c12)CCN(CCCCNC(=O)C1=Cc2ccccc2CN1)C3	None
		24949694	182770	0	UNDEFINED	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	6	0	7	3.4	c1cnc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		CHEMBL479026	182770	0	UNDEFINED	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	6	0	7	3.4	c1cnc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		43815	186920	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	186920	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	186920	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		11676600	187745	0	UNDEFINED	-1174	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	442	6	0	5	4.4	COc1cccc2cc3n(c12)CCN(CCCCN1CCn2c(cc4ccccc42)C1=O)C3	None
		CHEMBL495573	187745	0	UNDEFINED	-1174	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	442	6	0	5	4.4	COc1cccc2cc3n(c12)CCN(CCCCN1CCn2c(cc4ccccc42)C1=O)C3	None
		11704609	188023	0	UNDEFINED	-2691	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	427	6	0	5	3.6	N#Cc1cccc(N2CCN(CCCCN3CCn4c(cc5ccccc54)C3=O)CC2)c1	None
		CHEMBL497573	188023	0	UNDEFINED	-2691	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	427	6	0	5	3.6	N#Cc1cccc(N2CCN(CCCCN3CCn4c(cc5ccccc54)C3=O)CC2)c1	None
		11596521	188036	0	UNDEFINED	-18620	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	402	7	1	5	3.6	N#Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		CHEMBL497604	188036	0	UNDEFINED	-18620	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	402	7	1	5	3.6	N#Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		5280343	188275	124	3H-SCH23390	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	188275	124	3H-SCH23390	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	188275	124	3H-SCH23390	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		44581147	190374	0	UNDEFINED	-1659	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.6	COc1cccc2c1C1CCN(CCCCNC(=O)C3=Cc4ccccc4CN3)CC1=N2	None
		CHEMBL517730	190374	0	UNDEFINED	-1659	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.6	COc1cccc2c1C1CCN(CCCCNC(=O)C3=Cc4ccccc4CN3)CC1=N2	None
		24949388	190528	0	UNDEFINED	-6309	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	6	0	6	3.5	c1ccc(N2CCN(CCCSc3nc4ccccc4o3)CC2)nc1	None
		CHEMBL517962	190528	0	UNDEFINED	-6309	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	6	0	6	3.5	c1ccc(N2CCN(CCCSc3nc4ccccc4o3)CC2)nc1	None
		3672	192533	136	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	192533	136	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	193615	112	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	193615	112	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		2771	195017	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	195017	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	195017	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	195017	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		4495	196535	92	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	196535	92	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		45112568	198806	0	UNDEFINED	-229	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	None
		CHEMBL583422	198806	0	UNDEFINED	-229	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	None
		54677470	200551	115	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	200551	115	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	200551	115	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	202274	22	3H-SCH23390	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	202274	22	3H-SCH23390	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	202274	22	3H-SCH23390	-239	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		3036864	202754	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	3H-SCH23390	-26	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		5281600	203025	92	3H-SCH23390	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	203025	92	3H-SCH23390	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	203066	87	3H-SCH23390	-25	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	203066	87	3H-SCH23390	-25	40	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		1973	203483	15	3H-SCH23390	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	203483	15	3H-SCH23390	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	203483	15	3H-SCH23390	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		1614	203655	24	3H-SCH23390	-81	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		CHEMBL6731	203655	24	3H-SCH23390	-81	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		202478	204687	20	3H-SCH23390	-97	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		CHEMBL7393	204687	20	3H-SCH23390	-97	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		3821	204718	17	3H-SCH23390	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		CHEMBL742	204718	17	3H-SCH23390	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		5311189	204841	11	3H-SCH23390	-194	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		CHEMBL7549	204841	11	3H-SCH23390	-194	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		4158	205341	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	205341	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	205341	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		4054	205501	72	3H-SCH23390	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	205501	72	3H-SCH23390	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	205501	72	3H-SCH23390	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		5324346	205582	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL1409	205582	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL814	205582	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		7108	205758	110	3H-SCH23390	-8	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	199	0	1	2	3.9	c1ccc2c(c1)Nc1ccccc1S2	None
		CHEMBL828	205758	110	3H-SCH23390	-8	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	199	0	1	2	3.9	c1ccc2c(c1)Nc1ccccc1S2	None
		119607	206203	113	3H-SCH23390	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	206203	113	3H-SCH23390	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		3337	206367	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	206367	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	206367	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	206367	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	206367	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		444	206666	53	3H-SCH23390	-2089	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		CHEMBL894	206666	53	3H-SCH23390	-2089	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		16231	207509	57	3H-dopamine	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		CHEMBL945	207509	57	3H-dopamine	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		12057539	208041	42	3H-SCH23390	-18620	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	208041	42	3H-SCH23390	-18620	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	208041	42	3H-SCH23390	-18620	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		6852400	215937	0	3H-dopamine	-14125	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		6852400	215937	0	3H-SCH23390	-25118	22	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		6852400	215937	0	3H-SCH23390	-25118	22	Rhesus macaque	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-dopamine	-14125	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-SCH23390	-25118	22	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-SCH23390	-25118	22	Rhesus macaque	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		57174031	215940	0	3H-SCH23390	-1778	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		None	215943	0	3H-dopamine	-7943	11	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		165193	215945	0	3H-SCH23390	-42657	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		165193	215945	0	3H-SCH23390	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	215945	0	3H-SCH23390	-42657	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	215945	0	3H-SCH23390	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	215945	0	3H-SCH23390	-42657	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	215945	0	3H-SCH23390	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		164512405	215949	0	3H-SCH23390	-457	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
		164512405	215949	0	3H-SCH23390	-457	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
		11954224	215953	0	3H-SCH23390	-3467	58	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		3246155	215962	0	3H-dopamine	-43651	16	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		11954259	215979	0	3H-dopamine	-7762	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		57525649	215990	0	3H-SCH23390	-1	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	187	4	0	1	2.2	CC(CC1=CC=CC=C1)N(C)CC#C	None
		44134711	215991	0	3H-SCH23390	-112201	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	340	6	2	4	2.8	CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl	None
		None	215992	0	3H-SCH23390	-1071	11	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
		None	215993	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		6420041	215994	0	3H-SCH23390	-14	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	4	0	2	3.8	CN(C)CC=C(C1=CC=C(C=C1)Br)C2=CN=CC=C2	None
		104911	216019	0	3H-SCH23390	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	216027	0	3H-SCH23390	-10	12	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
		131632304	216037	0	3H-SCH23390	-70794	12	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		119380	216129	0	125I-SCH 23982	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	166	1	0	3	1.8	CC1=NOC(=C1)C2CCCN2C	None
		None	216135	0	3H-SCH23390	-10471	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		25137849	216179	0	3H-SCH23390	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	216179	0	3H-SCH23390	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	216234	0	3H-SCH23390	-13	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
		None	216239	0	3H-SCH23390	-95499	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		None	216254	0	3H-dopamine	-8317	19	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		5372683	216286	0	3H-dopamine	-1479	3	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	400	5	1	4	4.2	C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO	None
		None	216311	0	3H-SCH23390	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	216312	0	3H-SCH23390	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	216313	0	3H-SCH23390	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	216314	0	3H-SCH23390	-1	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	216315	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	216316	0	3H-SCH23390	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	216317	0	3H-SCH23390	-1	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	216318	0	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	216325	0	3H-SCH23390	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	216326	0	3H-SCH23390	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		4978	216328	0	3H-SCH23390	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	216329	0	3H-SCH23390	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	216330	0	3H-SCH23390	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	216331	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		None	216342	0	3H-SCH23390	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		135269	216389	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	216390	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	216391	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	216392	0	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	216393	0	3H-SCH23390	-1412	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	216394	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	216395	0	3H-SCH23390	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	216450	0	UNDEFINED	-660	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216450	0	UNDEFINED	-660	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	216489	0	3H-SCH23390	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		None	216494	0	3H-SCH23390	-1	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
		None	216567	0	UNDEFINED	-549	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		None	216720	0	UNDEFINED	-3090	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	3.1	CC1=C(C2=C(CC3C4=C2C=CC=C4CCN3)C=C1)O	None
		None	216722	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	601	23	0	3	11.9	CCCCCCCCCCCCCCCCCCCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC	None
		None	216723	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	363	6	0	3	5.3	CCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC	None
		None	216724	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	3	0	3	4.1	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OC(=O)C	None
		None	216732	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	4.1	CCCN1CCC2=C3C1CC4=C(C=CC(=C4)O)OC3=CC=C2	None
		None	216733	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	4.1	CCCN1CCC2=CC(=CC3=C2C1CC4=CC=CC=C4O3)O	None
		None	216772	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	4	1	3	4.3	CCCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		None	217160	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	436	9	2	5	4.7	CCCN(CCCCNC(=O)C1=CC2=CC=CC=C2C=C1)C3CCC4=C(C3)SC(=N4)N	None
		None	217272	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	4	0	4	4.2	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)OC(=O)C	None
		None	217273	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	0	4	5.3	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)CCC)OC	None
		None	217515	0	UNDEFINED	-1023	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	0	0	2	3.8	CC1CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2	None
		None	217516	0	UNDEFINED	-69	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	3	1	3	3.9	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)CC=C)O	None
		None	217517	0	UNDEFINED	-151	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	4	0	3	4.0	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)OCC=C	None
		None	217518	0	UNDEFINED	-346	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	0	0	2	4.5	CC1=CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2	None
		None	217519	0	UNDEFINED	-707	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	2	0	2	3.5	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#C	None
		None	217520	0	UNDEFINED	-74	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	2	1	2	3.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC=C)O	None
		None	217521	0	UNDEFINED	-831	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	3	0	2	4.0	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C	None
		None	217522	0	UNDEFINED	-19	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	0	2	5.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(C=C4)C(=C(O5)C)C	None
		None	217523	0	UNDEFINED	-30	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	2	0	2	5.3	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(C=C4)C=C(O5)C	None
		None	217524	0	UNDEFINED	-79	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	2	4.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#CC	None
		None	217525	0	UNDEFINED	-15	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	2	0	2	4.9	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(CC(O5)(C)C)C=C4	None
		None	217526	0	UNDEFINED	-12	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	4	1	2	4.7	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC=C)O	None
		None	217527	0	UNDEFINED	-67	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	5	0	2	5.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C(C)C	None
		None	217528	0	UNDEFINED	-26	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	5	0	2	5.2	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC(=C)C	None
		None	217529	0	UNDEFINED	-35	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	5	0	2	4.8	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C	None
		None	217537	0	UNDEFINED	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	4	1	2	5.4	CCCN1CCC2=CC=CC3=C2C1CC4=C(C=CC(=C43)O)CC=C(C)C	None
		None	217538	0	UNDEFINED	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	5.0	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC(=C)C)O	None
		1524	2181	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-SCH23390	-338	52	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		25058166	215960	0	UNDEFINED	-147	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	UNDEFINED	-147	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		126968774	215989	0	3H-dopamine	-42	8	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O	None
		1242	3613	27	3H-SCH23390	-6	18	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	-6	18	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	-6	18	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1353	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		45112462	196966	0	UNDEFINED	-831	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	None
		CHEMBL566533	196966	0	UNDEFINED	-831	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	None
		25058166	215960	0	3H-SCH23390 Low	-6	27	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390 Low	-6	27	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		3153	297	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	297	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	297	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		1212	1662	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		681	1465	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-dopamine	-23	39	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1353	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216719	0	UNDEFINED	-190	2	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	237	0	2	2	2.8	C1CNC2CC3=C(C4=C2C1=CC=C4)C(=CC=C3)O	None
		2726	919	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1218	3616	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		938	3616	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		CHEMBL353335	3616	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		2726	919	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		None	216959	0	UNDEFINED	1	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	365	5	0	4	4.5	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
		277	1301	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1353	1911	93	3H-SCH233930	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH233930	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH233930	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH233930	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH233930	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	2914	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2435	3590	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1353	1911	93	UNDEFINED	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	UNDEFINED	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	UNDEFINED	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	UNDEFINED	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	UNDEFINED	-38	83	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		277	1301	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		4508	3139	98	3H-dopamine	-239	12	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		4866774	3139	98	3H-dopamine	-239	12	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		509	3139	98	3H-dopamine	-239	12	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		838	3139	98	3H-dopamine	-239	12	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		CHEMBL1740	3139	98	3H-dopamine	-239	12	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		4249	78179	34	3H-dopamine	-1230	6	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	355	6	1	3	4.1	Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	None
		CHEMBL2104700	78179	34	3H-dopamine	-1230	6	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	355	6	1	3	4.1	Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	None
		681	1465	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	UNDEFINED	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		None	217365	0	UNDEFINED	-	1	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	409	2	3	4	5.0	CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O.Cl	None
		2337	3256	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		24949690	181606	0	UNDEFINED	-1819	3	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	None
		CHEMBL477200	181606	0	UNDEFINED	-1819	3	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	None
		2337	3256	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		681	1465	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	125I-SCH 23982	-154	39	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2865	4143	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		None	216774	0	UNDEFINED	-	1	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.5	CCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		2337	3256	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2865	4143	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		None	217363	0	UNDEFINED	-	1	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	331	1	2	3	4.0	CCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl	None
		1242	3613	27	3H-SCH23390 Low	-11	18	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390 Low	-11	18	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390 Low	-11	18	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		2105	3054	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-SCH23390	-537	33	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		135409468	2035	69	3H-SCH23390	-12	39	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	2035	69	3H-SCH23390	-12	39	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	2035	69	3H-SCH23390	-12	39	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		37459	746	13	3H-SCH23390	-8	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-8	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-8	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		1222	1664	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	3H-dopamine	-2344	33	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	3653	50	3H-dopamine	-31622	59	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-dopamine	-31622	59	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-dopamine	-31622	59	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-dopamine	-31622	59	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-dopamine	-31622	59	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398737	958	93	3H-SCH23390	-44	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-44	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-44	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-44	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-44	89	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		127708	112521	7	UNDEFINED	-22	5	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	112521	7	UNDEFINED	-22	5	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		135	2532	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-SCH23390	-91	58	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		16362	3125	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-SCH23390	-7413	30	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		681	1465	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390	-97	39	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		2389	3331	118	3H-SCH23390	-489	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-489	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-489	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-489	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-489	67	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		None	216959	0	UNDEFINED	-12	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	365	5	0	4	4.5	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
		1353	1911	93	UNDEFINED	-74	83	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	UNDEFINED	-74	83	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	UNDEFINED	-74	83	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	UNDEFINED	-74	83	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	UNDEFINED	-74	83	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216735	0	UNDEFINED	-	1	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	419	3	1	5	3.9	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O)Br	None
		1242	3613	27	3H-SCH23390	-5	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	-5	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	-5	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1890	2759	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	2759	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	2759	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	2759	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	2759	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		11954259	215979	0	3H-SCH23390	-5011	43	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		71299720	215951	0	3H-SCH23390	-1202	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		1353	1911	93	3H-SCH23390	-107	83	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-107	83	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-107	83	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-107	83	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-107	83	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		134	2514	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1613	2348	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		681	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		33630	178957	99	3H-dopamine	-281	28	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	178957	99	3H-dopamine	-281	28	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		24949534	189518	0	UNDEFINED	-2041	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	None
		CHEMBL514074	189518	0	UNDEFINED	-2041	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	None
		11653679	181191	1	UNDEFINED	-24	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL476108	181191	1	UNDEFINED	-24	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		None	216773	0	UNDEFINED	-	1	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	3	1	3	3.9	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		5018	3549	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	3549	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	3549	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	3549	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		172286	216387	0	3H-SCH23390	1	2	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	331	0	0	4	3.6	CN1CCN(CC1)C2=NC3=C(CC4=C2C=CS4)C=CC(=C3)Cl	None
		681	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-dopamine	-23	39	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		None	216382	0	3H-SCH23390	165	2	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	1	1	3	4.4	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OC=C4)O)Cl	None
		None	216726	0	UNDEFINED	-	1	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	343	1	2	3	4.5	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=CC=C4)O)C5=CC=C(C=C5)O	None
		15443	117810	96	3H-dopamine	-257	10	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	None
		CHEMBL340211	117810	96	3H-dopamine	-257	10	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	None
		5018	3549	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	3549	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	3549	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	3549	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		3036864	202754	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	202754	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	202754	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	202754	19	125I-Spectramide	-2	28	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		2286	3183	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		100	3805	58	3H-dopamine	-309	55	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-dopamine	-309	55	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-dopamine	-309	55	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-dopamine	-309	55	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-dopamine	-309	55	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1212	1662	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		11976	920	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		1212	1662	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1242	3613	27	3H-SCH23390	-1	18	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1242	3613	27	3H-SCH23390	1	18	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	-1	18	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	1	18	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	-1	18	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	1	18	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5281878	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-dopamine	-34	17	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1621	2429	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-SCH23390	-588	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		None	216282	0	3H-dopamine	2	2	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	1	2	2	1.5	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)N	None
		100	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		None	216730	0	UNDEFINED	-	1	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	325	3	2	4	3.6	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)O)O	None
		100	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-dopamine	-309	55	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		30137	2877	0	3H-SCH23390	-676	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	2877	0	3H-SCH23390	-676	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	2877	0	3H-SCH23390	-676	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		1153	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	1628	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		None	216370	0	3H-SCH23390	-11220	2	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	487	8	2	4	3.9	CNC1=C(C=C(C(=C1)OC)C(=O)NCCN(C)CC2=CC=C(C=C2)I)Cl	None
		135398737	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1524	2181	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-SCH23390	-79	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		None	216284	0	3H-dopamine	-741	2	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	454	6	1	4	4.8	C1CN(CCN1CCCC2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F)CCO	None
		135398737	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-44	89	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		242	470	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	470	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		4106	2502	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-SCH23390	-5	34	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		None	216738	0	UNDEFINED	-	1	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	453	2	2	5	3.5	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O)I	None
		37459	746	13	3H-SCH23390	-53	25	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-53	25	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-53	25	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		6603820	95774	19	3H-SCH23390	1	13	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	1	13	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		1238	203174	24	3H-SCH23390	-5	16	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	3H-SCH23390	-5	16	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		3153	297	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	297	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	297	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		46780481	107531	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		20840341	216177	0	3H-SCH23390	-3	4	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	451	5	1	3	6.2	C1CN(CCC1CCO)CCC=C2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F	None
		6603820	95774	19	3H-SCH23390	-2	13	Rhesus macaque	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	-2	13	Rhesus macaque	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		1524	2181	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-SCH23390	-338	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		484	2858	51	3H-dopamine	1	35	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-dopamine	1	35	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-dopamine	1	35	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		None	216721	0	UNDEFINED	-165	2	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	4.2	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)C)O	None
		24949857	181767	0	UNDEFINED	-7413	3	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	None
		CHEMBL477765	181767	0	UNDEFINED	-7413	3	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	None
		25212275	174421	0	UNDEFINED	-4897	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL455288	174421	0	UNDEFINED	-4897	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
		25212276	190066	0	UNDEFINED	-575	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL517244	190066	0	UNDEFINED	-575	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
		3151	1462	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	1462	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	1462	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	1462	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	1462	97	3H-SCH23390	-2630	27	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		135398737	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-dopamine	-204	89	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		126968774	215989	0	3H-SCH23390	-831	8	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O	None
		5475158	67213	25	3H-SCH23390	-489	14	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		CHEMBL18786	67213	25	3H-SCH23390	-489	14	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		1212	1662	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2389	3331	118	UNDEFINED	-346	67	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	UNDEFINED	-346	67	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	UNDEFINED	-346	67	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	UNDEFINED	-346	67	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	UNDEFINED	-346	67	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	3805	58	3H-SCH23390	-16	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-SCH23390	-16	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-SCH23390	-16	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-SCH23390	-16	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-SCH23390	-16	55	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		6603820	95774	19	3H-SCH23390	-4	13	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	-4	13	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		None	216385	0	125I-SCH 23982	74	2	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	365	2	3	4	3.7	C1C2CC3CC1CC(C2)(C3)C4CC5=C(C=CC(=C5O)O)C(O4)CN.Cl	None
		4106	2502	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	2502	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	2502	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	2502	22	3H-dopamine	-524	34	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2435	3590	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		25058166	215960	0	UNDEFINED	-147	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	UNDEFINED	-147	27	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		None	216736	0	UNDEFINED	-	1	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	481	4	0	5	4.1	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC)I	None
		None	216341	0	3H-SCH23390	-281	19	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		3294	2006	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-SCH23390	-56	45	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		134	2514	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		None	216233	0	3H-SCH23390	-3090	3	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	3	4.3	CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O	None
		2398	954	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		10742	3617	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		1225	3617	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		CHEMBL35354	3617	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		2470	3653	50	3H-SCH23390	-4168	59	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-SCH23390	-4168	59	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-SCH23390	-4168	59	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-SCH23390	-4168	59	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-SCH23390	-4168	59	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		4382	104780	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		86470	104780	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		CHEMBL1256484	104780	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		CHEMBL31088	104780	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		1212	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2389	3331	118	3H-SCH23390	-346	67	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-346	67	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-346	67	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-346	67	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-346	67	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		44591134	176200	0	UNDEFINED	-194	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL459373	176200	0	UNDEFINED	-194	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		681	1465	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390	-154	39	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1212	1662	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		46780481	107531	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		None	216727	0	UNDEFINED	-	1	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	341	3	1	5	3.2	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O	None
		1212	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2181	3128	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-SCH23390	-2041	35	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		None	217161	0	UNDEFINED	-158	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	532	10	0	4	8.0	CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5	None
		2726	919	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	919	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	2914	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	2914	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11976	920	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	2914	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135	2532	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-dopamine	-457	58	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	216960	0	UNDEFINED	-7	2	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	339	0	3	6	3.0	CN1CCC2=C3C1CC4=C(C3=CC5=C2SC(=N5)N)C(=C(C=C4)O)O	None
		None	216776	0	UNDEFINED	1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	251	0	1	2	3.1	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O	None
		1242	3613	27	3H-SCH23390	1	18	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	1	18	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	1	18	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		73333	5963	31	UNDEFINED	-16	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL1079935	5963	31	UNDEFINED	-16	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		4452	2762	19	3H-SCH23390	-89125	19	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		983	2762	19	3H-SCH23390	-89125	19	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		CHEMBL20734	2762	19	3H-SCH23390	-89125	19	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		2337	3256	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398737	958	93	3H-SCH23390	-37	89	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-37	89	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-37	89	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-37	89	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-37	89	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2389	3331	118	3H-SCH23390	-489	67	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-489	67	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-489	67	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-489	67	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-489	67	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1353	1911	93	3H-SCH23390	-30	83	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-30	83	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-30	83	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-30	83	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-30	83	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-SCH23390	-38	83	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-38	83	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-38	83	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-38	83	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-38	83	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216718	0	UNDEFINED	-60	2	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	263	1	0	1	4.0	CCC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)C	None
		None	215938	0	3H-SCH23390	-45708	21	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		None	217366	0	UNDEFINED	-	1	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	345	2	2	3	4.4	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl	None
		1153	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	1628	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		2601	3780	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1028	291	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	291	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	291	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	291	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	291	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	291	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		135398737	958	93	3H-dopamine	-204	89	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-dopamine	-204	89	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-dopamine	-204	89	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-dopamine	-204	89	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-dopamine	-204	89	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		125564	666	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		388	666	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		7670	666	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		CHEMBL178803	666	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		DB09223	666	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		135398737	958	93	3H-SCH233930	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH233930	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH233930	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH233930	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH233930	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		209	3057	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		135398737	958	93	UNDEFINED	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	-44	89	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		134	2514	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		25058166	215960	0	UNDEFINED	-144	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	UNDEFINED	-144	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		None	216729	0	UNDEFINED	-	1	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.9	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O	None
		10145	216728	0	UNDEFINED	-	1	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	355	4	0	5	3.5	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC	None
		None	216957	0	UNDEFINED	-1	2	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	265	0	2	3	2.6	CN1CCC2=C3C1CC4=C(C3=CC(=C2)N)C(=CC=C4)N	None
		185	4006	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		122324	205	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
		6077	205	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
		CHEMBL86931	205	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
		37459	746	13	3H-SCH23390	-10	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-10	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-10	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		5281878	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-2	17	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281878	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-34	17	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		9861622	199444	5	3H-SCH23390	1202	2	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	None
		CHEMBL59139	199444	5	3H-SCH23390	1202	2	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	None
		62865	1274	0	3H-SCH23390	-2	14	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	3H-SCH23390	-2	14	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	3H-SCH23390	-2	14	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	3H-SCH23390	-2	14	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	3H-SCH23390	-2	14	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		1621	2429	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	3H-dopamine	-97	45	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2865	4143	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		11954224	215953	0	3H-dopamine	-426	58	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1242	3613	27	3H-SCH23390 High	-11	18	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390 High	-11	18	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390 High	-11	18	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1427	2013	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	2013	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	2013	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	2013	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	2013	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		10333195	48186	0	UNDEFINED	-10	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		CHEMBL155208	48186	0	UNDEFINED	-10	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		44591099	176190	0	UNDEFINED	-1122	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL459350	176190	0	UNDEFINED	-1122	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		135398745	2914	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		None	217364	0	UNDEFINED	-	1	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	393	2	2	3	5.3	CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl	None
		1353	1911	93	3H-SCH23390	-512	83	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-512	83	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-512	83	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-512	83	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-512	83	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	UNDEFINED	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	UNDEFINED	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	UNDEFINED	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	UNDEFINED	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	UNDEFINED	-74	83	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135	2532	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-SCH23390	-457	58	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		6852400	215937	0	3H-SCH23390	-14125	22	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-SCH23390	-14125	22	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		186	1807	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	1807	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	1807	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		11696813	187918	12	UNDEFINED	-316	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		CHEMBL496739	187918	12	UNDEFINED	-316	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		6603820	95774	19	125I-SCH 23982	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	125I-SCH 23982	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		2865	4143	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2105	3054	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-SCH23390	-537	33	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		1212	1662	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		None	216567	0	UNDEFINED	-549	6	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		30137	2877	0	UNDEFINED	-3981	10	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	2877	0	UNDEFINED	-3981	10	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	2877	0	UNDEFINED	-3981	10	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		135398745	2914	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		6603820	95774	19	3H-SCH23390	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	-4	13	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		10707972	169056	0	UNDEFINED	1	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		CHEMBL439639	169056	0	UNDEFINED	1	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	UNDEFINED	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	-83	89	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2470	3653	50	3H-SCH23390	-51286	59	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-SCH23390	-51286	59	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-SCH23390	-51286	59	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-SCH23390	-51286	59	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-SCH23390	-51286	59	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	1911	93	3H-SCH23390	-38	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-38	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-38	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-38	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-38	83	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		73453	29616	24	3H-dopamine	-51	17	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		CHEMBL1385840	29616	24	3H-dopamine	-51	17	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		2470	3653	50	3H-SCH23390	-10964	59	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-SCH23390	-10964	59	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-SCH23390	-10964	59	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-SCH23390	-10964	59	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-SCH23390	-10964	59	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		25293	215965	0	3H-dopamine	-724	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	443	6	1	3	5.4	C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F	None
		44448059	94820	0	UNDEFINED	5	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		CHEMBL253530	94820	0	UNDEFINED	5	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		25058166	215960	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		213	3853	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	3H-SCH23390	-12	44	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		681	1465	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390	-97	39	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		13994416	190690	1	UNDEFINED	-851	2	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1C(C2)N(C)CC3	None
		CHEMBL5181992	190690	1	UNDEFINED	-851	2	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1C(C2)N(C)CC3	None
		5018	3549	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	3549	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	3549	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	3549	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		5770	205058	82	3H-SCH23390	-2	7	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		CHEMBL772	205058	82	3H-SCH23390	-2	7	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		242	470	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2337	3256	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1524	2181	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-SCH23390	-301	52	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		5281878	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-2	17	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		37459	746	13	3H-SCH23390	-10	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-10	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-10	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		1577	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	3703	110	None	-70	21	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5281878	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-11	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2402	3370	62	None	-74	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	3370	62	None	-74	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	3370	62	None	-74	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	3370	62	None	-74	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	3370	62	None	-74	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		1212	1662	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	1662	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		10742	3617	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		1225	3617	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		CHEMBL35354	3617	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		6603820	95774	19	3H-SCH23390	1	13	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	1	13	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		2662	11384	131	None	-3	30	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	11384	131	None	-3	30	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		441383	20333	57	None	-12	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL1306	20333	57	None	-12	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		28417	40039	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		CHEMBL1479	40039	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		2105	3054	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2105	3054	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-SCH23390	-645	33	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	3H-SCH23390	-645	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		25058166	215960	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390	-144	27	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		4011	82408	49	UNDEFINED	-64	24	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	UNDEFINED	-64	24	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		135398737	958	93	3H-SCH23390	-169	89	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-169	89	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-169	89	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-169	89	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-169	89	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5018	3549	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	3549	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	3549	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	3549	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		115237	55585	119	3H-SCH23390	-74	54	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-SCH23390	-74	54	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1242	3613	27	3H-SCH23390	1	18	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	1	18	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	1	18	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		242	470	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		16363	596	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		312	596	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		9215	596	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL297302	596	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB12867	596	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		16362	3125	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-dopamine	-30199	30	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		1816	2540	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		3294	2006	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-SCH23390	-56	45	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2337	3256	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135	2532	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	3H-MIANSERIN	-91	58	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		44448070	94893	0	UNDEFINED	3	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	None
		CHEMBL254147	94893	0	UNDEFINED	3	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	None
		25186021	188024	0	UNDEFINED	-1318	3	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	None
		CHEMBL497574	188024	0	UNDEFINED	-1318	3	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	None
		25058166	215960	0	3H-SCH23390	-147	27	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390	-147	27	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		11712530	187890	0	UNDEFINED	-41686	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	None
		CHEMBL496531	187890	0	UNDEFINED	-41686	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	None
		2726	919	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		209	3057	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	3057	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	3057	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	3057	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	3057	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		None	216567	0	UNDEFINED	-549	6	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		681	1465	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390	-154	39	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1222	1664	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	1664	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	1664	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	1664	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	1664	49	3H-SCH23390	-741	33	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		None	215971	0	3H-SCH23390	-9772	15	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		2337	3256	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398745	2914	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		None	216775	0	UNDEFINED	1	4	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.2	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		None	216775	0	UNDEFINED	-1	4	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.2	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		25186569	176982	0	UNDEFINED	-45708	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	None
		CHEMBL462508	176982	0	UNDEFINED	-45708	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	None
		None	216232	0	3H-SCH23390	-11	4	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	226	0	2	2	1.4	C1CCC(=O)NCCCCCC(=O)NCC1	None
		1524	2181	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	3H-SCH23390	-79	52	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		219050	3373	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	3373	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	3373	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		5281878	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281878	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-4	17	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-11	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		30137	2877	0	3H-SCH23390	-1202	10	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	2877	0	3H-SCH23390	-1202	10	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	2877	0	3H-SCH23390	-1202	10	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		6446379	216285	0	3H-dopamine	-154	2	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	472	5	1	4	5.1	C1CN(CCN1CC/C=C/2\C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO.Cl.Cl	None
		10264969	48295	0	UNDEFINED	-6	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		CHEMBL155352	48295	0	UNDEFINED	-6	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		None	216739	0	UNDEFINED	-	1	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	405	2	2	5	3.6	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O)Br	None
		2181	3128	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	3128	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	3128	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	3128	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	3128	46	3H-dopamine	-4073	35	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		None	216567	0	UNDEFINED	-549	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		46780481	107531	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		64143	198864	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
		CHEMBL584	198864	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
		2477	745	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	745	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	745	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	745	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	745	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2780	110529	36	None	-138	10	Bovine	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	Drug Central	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		CHEMBL325109	110529	36	None	-138	10	Bovine	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	Drug Central	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		176	398	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2157	398	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2566	398	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		CHEMBL633	398	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		DB01118	398	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		3198	205513	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	205513	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	205513	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		2812	4779	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	4779	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		1016	3747	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	3747	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	3747	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	3747	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	3747	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	3747	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		1816	2540	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		1816	2540	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	2540	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	2540	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	2540	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	2540	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		448537	160250	89	None	-28	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		CHEMBL411	160250	89	None	-28	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		4189	206922	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	206922	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	206922	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1042	1581	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	1581	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	1581	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	1581	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	1581	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		2407	3372	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		59227	3372	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		941	3372	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		CHEMBL1303	3372	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		DB05271	3372	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		5353853	17986	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		9556529	17986	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1262	17986	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		11154555	800	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5037	800	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		7671	800	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL2028019	800	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL3085826	800	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB06016	800	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2247	505	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	505	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	505	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	505	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	505	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		12488	1657	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		941361	1657	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		CHEMBL30008	1657	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		DB04841	1657	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		2351	3286	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	3286	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	3286	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	3286	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	3286	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		240	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	944	43	None	-19	24	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		1830	2590	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	2590	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	2590	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	2590	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	2590	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		None	216383	0	3H-SCH23390	1737	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	2	1	5	2.9	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)[N+](=O)[O-]	None
		11057	176149	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	176149	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	176149	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	176149	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		135	2532	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-46	58	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2286	3183	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	3183	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	3183	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	3183	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	3183	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2600	3779	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	3779	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	3779	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	3779	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	3779	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		6917970	3691	61	3H-SCH23390	-1	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	3691	61	3H-SCH23390	-1	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	3691	61	3H-SCH23390	-1	34	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		2284	3182	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		10531	1420	21	None	-218	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	1420	21	None	-218	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	1420	21	None	-218	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	1420	21	None	-218	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	1420	21	None	-218	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		3117	207841	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		CHEMBL964	207841	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		2389	3331	118	UNDEFINED	-346	67	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	UNDEFINED	-346	67	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	UNDEFINED	-346	67	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	UNDEFINED	-346	67	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	UNDEFINED	-346	67	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3947	206395	53	3H-SCH23390	-74	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	206395	53	3H-SCH23390	-74	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		5	139	72	3H-SCH23390	-16595	54	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-SCH23390	-16595	54	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-SCH23390	-16595	54	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-SCH23390	-16595	54	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		None	216234	0	3H-SCH23390	-6	6	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
		None	216234	0	3H-SCH23390	-6	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
		11954259	215979	0	3H-SCH23390	-169	43	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		681	1465	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390 High	-23	39	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		115237	55585	119	3H-SCH23390	-2511	54	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-SCH23390	-2511	54	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		3153	297	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	297	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	297	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		135398745	2914	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		31116	216283	0	3H-dopamine	-37	2	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	609	5	3	6	2.6	CC(C)C1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		135398745	2914	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216737	0	UNDEFINED	-	1	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	433	4	0	5	4.2	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC)Br	None
		2389	3331	118	3H-SCH23390	-489	67	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-489	67	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-489	67	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-489	67	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-489	67	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		None	217271	0	UNDEFINED	-	1	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	323	2	0	4	3.4	CC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
		135398737	958	93	UNDEFINED	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5568	197500	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		66069	197500	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		CHEMBL1201102	197500	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		CHEMBL570	197500	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		16362	3125	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-dopamine	-30199	30	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		185	4006	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		135398737	958	93	3H-SCH23390	-44	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-44	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-44	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-44	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-44	89	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1613	2348	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11954259	215979	0	3H-dopamine	-7762	43	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		None	216567	0	UNDEFINED	-549	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		3294	2006	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	3H-SCH23390	-794	45	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2995	204405	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		2995	204405	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		135398737	958	93	3H-SCH23390	-22	89	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-22	89	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-22	89	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-22	89	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-22	89	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2389	3331	118	3H-SCH23390	-346	67	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-346	67	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-346	67	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-346	67	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-346	67	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		11654739	176848	0	UNDEFINED	-20417	4	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	None
		CHEMBL461236	176848	0	UNDEFINED	-20417	4	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	None
		1242	3613	27	125I-SCH 23982	-5	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	125I-SCH 23982	-5	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	125I-SCH 23982	-5	18	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		24949693	182304	0	UNDEFINED	-7244	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		CHEMBL478413	182304	0	UNDEFINED	-7244	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2389	3331	118	3H-SCH233930	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH233930	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH233930	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH233930	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH233930	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2470	3653	50	3H-SCH23390	-4168	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-SCH23390	-4168	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-SCH23390	-4168	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-SCH23390	-4168	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-SCH23390	-4168	59	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	1911	93	3H-SCH23390	-38	83	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-38	83	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-38	83	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-38	83	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-38	83	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	2914	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2389	3331	118	UNDEFINED	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	UNDEFINED	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	UNDEFINED	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	UNDEFINED	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	UNDEFINED	-489	67	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	3805	58	3H-SCH23390	-16	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-SCH23390	-16	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-SCH23390	-16	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-SCH23390	-16	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-SCH23390	-16	55	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		None	216327	0	3H-SCH23390	16	28	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		135	2532	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	2532	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	2532	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	2532	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	2532	43	None	-91	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	216734	0	UNDEFINED	-	1	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	467	3	1	5	3.8	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O)I	None
		11954224	215953	0	None	-3467	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		242	470	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		26987	949	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	949	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	949	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	949	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	949	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		2585	803	103	None	-112	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		522	803	103	None	-112	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		551	803	103	None	-112	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		CHEMBL723	803	103	None	-112	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		DB01136	803	103	None	-112	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		31101	729	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	None	-436	36	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		6603820	95774	19	3H-SCH23390	1	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	1	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		3191	102858	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	102858	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		107715	200945	22	None	-144	19	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL1255837	200945	22	None	-144	19	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL601773	200945	22	None	-144	19	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		3168	9262	92	None	-89	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	9262	92	None	-89	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		150	2509	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		1764	2509	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		8226	2509	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		CHEMBL1201356	2509	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		DB00353	2509	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		2407	3372	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		59227	3372	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		941	3372	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		CHEMBL1303	3372	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		DB05271	3372	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		5440	28724	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		CHEMBL1378	28724	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		4011	82408	49	None	-64	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	82408	49	None	-64	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		134	2514	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	2514	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	2514	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	2514	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	2514	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1530	2182	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	2182	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	2182	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	2182	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	2182	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		68663	27282	23	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	None
		CHEMBL136711	27282	23	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	None
		135398737	958	93	None	-204	89	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-204	89	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-204	89	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-204	89	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-204	89	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	958	93	None	-37	89	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-37	89	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-37	89	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-37	89	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-37	89	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2337	3256	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		7077	66959	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
		CHEMBL186720	66959	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
		CHEMBL3925724	66959	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
		2105	3054	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	3054	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	3054	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	3054	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	3054	37	None	-537	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2470	3653	50	None	-4168	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	None	-4168	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	None	-4168	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	None	-4168	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	None	-4168	59	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3561	19077	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		CHEMBL1289	19077	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		1971	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	2866	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		5462328	217737	0	None	1	3	Rat	8.2	pKi	=	8.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	Drug Central	369	2	0	6	2.0	CN1CC[C@]23[C@H]4OC5=C(OC(C)=O)C=CC(C[C@@H]1[C@@H]2C=C[C@@H]4OC(C)=O)=C35	None
		2398	954	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	954	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	954	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	954	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	954	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		3294	2006	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	2006	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	2006	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	2006	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	2006	111	None	-56	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2435	3590	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		134551	358	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	358	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	358	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	358	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		37	778	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		460	778	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		54746	778	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		CHEMBL1201087	778	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		DB00248	778	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		1524	2181	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	2181	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	2181	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	2181	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	2181	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	2181	96	None	-79	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		191	403	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	403	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	403	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	403	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	403	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		1621	2429	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	2429	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	2429	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	2429	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	2429	17	None	-112	45	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		11978813	721	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	721	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	721	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	721	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	721	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		681	1465	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	None	-97	39	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		33630	178957	99	None	-5	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	178957	99	None	-5	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		52919	14450	48	None	-15	4	Pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1200986	14450	48	None	-15	4	Pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		135398737	958	93	None	-44	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-44	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-44	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-44	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-44	89	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	1301	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1712	2492	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	2492	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	2492	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	2492	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	2492	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		2389	3331	118	3H-SCH23390	-489	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-489	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-489	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-489	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-489	67	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2448	99323	70	3H-dopamine	-426	18	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	99323	70	3H-dopamine	-426	18	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		1042	1581	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	1581	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	1581	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	1581	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	1581	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		None	216776	0	UNDEFINED	-2	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	251	0	1	2	3.1	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O	None
		10265732	94849	0	UNDEFINED	2	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		CHEMBL253738	94849	0	UNDEFINED	2	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		2389	3331	118	3H-SCH23390	-346	67	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-346	67	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-346	67	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-346	67	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-346	67	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		185	4006	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	4006	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	4006	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	4006	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		44448063	155245	0	UNDEFINED	3	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		CHEMBL402736	155245	0	UNDEFINED	3	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		68617	205527	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	205527	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	205527	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		1242	3613	27	125I-SCH 23982	1	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	125I-SCH 23982	1	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	125I-SCH 23982	1	18	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1588	2325	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		10355510	155662	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		CHEMBL404865	155662	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		None	216730	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	325	3	2	4	3.6	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)O)O	None
		1353	1911	93	3H-dopamine	-512	83	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-dopamine	-512	83	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-dopamine	-512	83	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-dopamine	-512	83	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-dopamine	-512	83	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		44448061	94847	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		CHEMBL253736	94847	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		None	217367	0	UNDEFINED	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	3	2	3	5.7	CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl	None
		20840341	216177	0	3H-dopamine	-75	4	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	451	5	1	3	6.2	C1CN(CCC1CCO)CCC=C2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F	None
		115237	55585	119	3H-SCH23390	-2511	54	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	3H-SCH23390	-2511	54	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		31101	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		25058166	215960	0	3H-SCH23390	-144	27	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390	-144	27	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		16362	3125	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-dopamine	-30199	30	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		10660476	47373	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		CHEMBL154468	47373	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		134551	358	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	358	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	358	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	358	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		135398745	2914	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		31101	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	729	40	3H-SCH23390	-436	36	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		127708	112521	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	112521	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		228	445	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	445	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	445	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	445	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	445	28	None	-4	24	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		2448	99323	70	None	-5	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	99323	70	None	-5	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		1212	1662	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1353	1911	93	None	-30	83	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-30	83	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-30	83	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-30	83	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-30	83	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		180	401	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1588	2325	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	2325	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	2325	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	2325	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	2325	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2274	3173	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2726	919	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		25058166	215960	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		1613	2348	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	2348	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	2348	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	2348	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	2348	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		228	445	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	445	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	445	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	445	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	445	28	None	-30	24	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		212	3806	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	3806	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	3806	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	3806	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	3806	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		135398737	958	93	None	-83	89	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	None	-83	89	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	None	-83	89	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	None	-83	89	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	None	-83	89	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		21302490	112805	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
		CHEMBL3233142	112805	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
		CHEMBL3306803	112805	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
		115237	55585	119	None	-74	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	55585	119	None	-74	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		135398745	2914	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		133	2496	52	None	-30	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	2496	52	None	-30	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	2496	52	None	-30	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	2496	52	None	-30	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	2496	52	None	-30	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2726	919	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		103	4153	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		1212	1662	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	1662	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	1662	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	1662	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	1662	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2389	3331	118	None	-346	67	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-346	67	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-346	67	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-346	67	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-346	67	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2389	3331	118	None	-489	67	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	None	-489	67	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	None	-489	67	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	None	-489	67	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	None	-489	67	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3389	217711	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		1353	1911	93	None	-74	83	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-74	83	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-74	83	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-74	83	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-74	83	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	2914	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11976	920	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	920	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	920	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	920	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		5281878	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	None	-34	17	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		6761	67799	19	None	-5	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL1909072	67799	19	None	-5	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1353	1911	93	None	-38	83	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	None	-38	83	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	None	-38	83	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	None	-38	83	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	None	-38	83	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		16351	102730	47	None	-4	6	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL304902	102730	47	None	-4	6	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		2435	3590	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	3590	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	3590	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	3590	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	3590	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		37459	746	13	3H-dopamine	-53	25	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-dopamine	-53	25	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-dopamine	-53	25	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		127708	112521	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	112521	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		7153	98020	77	3H-SCH23390	-371	34	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	98020	77	3H-SCH23390	-371	34	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		103	4153	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2284	3182	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	3182	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	3182	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	3182	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	3182	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2337	3256	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	3256	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	3256	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	3256	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	3256	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		25186023	187744	0	UNDEFINED	-50118	4	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	None
		CHEMBL495572	187744	0	UNDEFINED	-50118	4	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	None
		25058166	215960	0	UNDEFINED	-144	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	UNDEFINED	-144	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		44448067	155529	0	UNDEFINED	-	1	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	None
		CHEMBL404240	155529	0	UNDEFINED	-	1	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	None
		5281878	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-34	17	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2726	919	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1241	100179	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL288090	100179	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL552611	100179	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		30137	2877	0	UNDEFINED	-3981	10	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	2877	0	UNDEFINED	-3981	10	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	2877	0	UNDEFINED	-3981	10	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		2726	919	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		214	3860	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	3860	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	3860	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	3860	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	3860	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	3860	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5567	42802	27	3H-dopamine	-812	8	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
		CHEMBL15023	42802	27	3H-dopamine	-812	8	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
		2389	3331	118	3H-SCH23390	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	3331	118	3H-SCH23390	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	3331	118	3H-SCH23390	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	3331	118	3H-SCH23390	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	3331	118	3H-SCH23390	-346	67	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	3805	58	3H-SCH23390	-309	55	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-SCH23390	-309	55	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-SCH23390	-309	55	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-SCH23390	-309	55	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-SCH23390	-309	55	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		None	217138	0	UNDEFINED	-199	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	359	1	3	4	4.2	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O	None
		1353	1911	93	3H-SCH23390	-52	83	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-52	83	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-52	83	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-52	83	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-52	83	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216415	0	3H-SCH23390	-691	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	453	8	1	4	4.6	COC1=CC=CC=C1N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4C=C3.Cl	None
		16362	3125	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	3125	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	3125	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	3125	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	3125	71	3H-dopamine	-30199	30	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2470	3653	50	3H-SCH23390	-31622	59	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-SCH23390	-31622	59	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-SCH23390	-31622	59	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-SCH23390	-31622	59	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-SCH23390	-31622	59	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		681	1465	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	3H-SCH23390	-1548	39	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		None	216958	0	UNDEFINED	8	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	1	1	3	3.0	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)N	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2107	3055	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		4747	3055	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		9216	3055	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		CHEMBL251940	3055	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		DB01608	3055	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		25058166	215960	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		2865	4143	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		681	1465	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	None	-23	39	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		228	445	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	445	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	445	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	445	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	445	28	None	-35	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		5281878	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	None	-2	17	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		62865	1274	0	None	-2	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	1274	0	None	-2	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	1274	0	None	-2	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	1274	0	None	-2	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	1274	0	None	-2	14	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		1153	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	1628	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		25058166	215960	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-dopamine	-6	27	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		1238	203174	24	None	-5	16	Rat	8.1	pKi	=	8.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	203174	24	None	-5	16	Rat	8.1	pKi	=	8.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		46780481	107531	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	107531	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	107531	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	107531	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		37459	746	13	3H-dopamine	-53	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-dopamine	-53	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-dopamine	-53	25	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		15139	199080	52	3H-dopamine	-794	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	356	7	0	4	3.6	COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL58792	199080	52	3H-dopamine	-794	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	356	7	0	4	3.6	COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		16219195	216131	0	3H-dopamine	1	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	325	1	1	5	2.9	CN1CCC2=CC3=C(C4=C2C1CC5=C4C(=C(C=C5)OC)O)OCO3	None
		None	216725	0	UNDEFINED	-	1	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	3.9	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)F)C(=CC=C4)OC=O	None
		5281878	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-dopamine	-34	17	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		180	401	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1353	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		484	2858	51	3H-dopamine	1	35	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	2858	51	3H-dopamine	1	35	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	2858	51	3H-dopamine	1	35	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		2780	110529	36	3H-SCH23390	-630	10	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		CHEMBL325109	110529	36	3H-SCH23390	-630	10	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		1353	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-38	83	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		44448064	94874	0	UNDEFINED	1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		CHEMBL253947	94874	0	UNDEFINED	1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		1353	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-SCH23390	-74	83	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL146246	38278	0	3H-SCH23390	-2290	10	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	401	5	1	5	2.2	NS(=O)(=O)c1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	None
		103	4153	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	4153	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	4153	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	4153	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	4153	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2470	3653	50	3H-SCH23390	-51286	59	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	3653	50	3H-SCH23390	-51286	59	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	3653	50	3H-SCH23390	-51286	59	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	3653	50	3H-SCH23390	-51286	59	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	3653	50	3H-SCH23390	-51286	59	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		279	1661	26	3H-SCH23390	-17	18	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		49381	1661	26	3H-SCH23390	-17	18	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		CHEMBL63756	1661	26	3H-SCH23390	-17	18	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		135398745	2914	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	2914	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	2914	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	2914	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		44448060	155244	0	UNDEFINED	-1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	None
		CHEMBL402735	155244	0	UNDEFINED	-1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	None
		None	217133	0	UNDEFINED	-269	11	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	116	4	0	2	1.4	CCCCN(C)N=O	None
		25058166	215960	0	3H-SCH23390	-147	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	215960	0	3H-SCH23390	-147	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		135398737	958	93	3H-SCH23390	-83	89	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	3H-SCH23390	-83	89	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	3H-SCH23390	-83	89	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	3H-SCH23390	-83	89	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	3H-SCH23390	-83	89	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		44591012	175580	0	UNDEFINED	-177	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL457957	175580	0	UNDEFINED	-177	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
		None	217137	0	UNDEFINED	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	343	1	2	3	4.5	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5	None
		3168	9262	92	3H-dopamine	-1318	21	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	9262	92	3H-dopamine	-1318	21	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		180	401	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	401	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	401	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	401	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	401	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		135398737	958	93	UNDEFINED	-44	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	958	93	UNDEFINED	-44	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	958	93	UNDEFINED	-44	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	958	93	UNDEFINED	-44	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	958	93	UNDEFINED	-44	89	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	3805	58	3H-SCH23390	-47	55	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	3805	58	3H-SCH23390	-47	55	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	3805	58	3H-SCH23390	-47	55	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	3805	58	3H-SCH23390	-47	55	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	3805	58	3H-SCH23390	-47	55	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		681	1465	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	1465	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	1465	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	1465	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	1465	72	None	-154	39	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		242	470	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	470	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	470	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	470	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	470	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		37459	746	13	3H-SCH23390	-21	25	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	746	13	3H-SCH23390	-21	25	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	746	13	3H-SCH23390	-21	25	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		2865	4143	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	4143	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	4143	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	4143	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	4143	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		6603820	95774	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	95774	19	3H-SCH23390	1	13	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		2726	919	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		6852400	215937	0	3H-SCH23390	-22387	22	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	215937	0	3H-SCH23390	-22387	22	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		None	216135	0	3H-KETANSERIN	-9332	24	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		5281878	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	1660	35	3H-SCH23390	-11	17	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1353	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	1911	93	3H-dopamine	-512	83	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	216731	0	UNDEFINED	-	1	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	311	2	3	4	3.3	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)O)C(=C(C=C4)O)O	None
		24949535	181559	0	UNDEFINED	-1122	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	None
		CHEMBL476722	181559	0	UNDEFINED	-1122	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	None
		5074	3332	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	3332	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	3332	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	3332	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		None	217368	0	UNDEFINED	-	1	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	423	3	3	4	5.4	CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O.Cl	None
		2726	919	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	919	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	919	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	919	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	919	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		5	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	139	72	3H-SCH23390	-23442	54	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1242	3613	27	3H-SCH23390	-5	18	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	3613	27	3H-SCH23390	-5	18	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	3613	27	3H-SCH23390	-5	18	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		5281878	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		5281878	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		5281881	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		5281881	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		948	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		948	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		968	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		968	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		CHEMBL42055	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		CHEMBL42055	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		CHEMBL54661	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		CHEMBL54661	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		DB00875	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		DB00875	1660	35	None	-2	17	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		681	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		681	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		940	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		940	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		947	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		947	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		CHEMBL59	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		CHEMBL59	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		DB00988	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		DB00988	1465	72	None	-154	39	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		5	139	72	None	-23442	54	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		5202	139	72	None	-23442	54	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		CHEMBL39	139	72	None	-23442	54	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		DB08839	139	72	None	-23442	54	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		1153	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		12668023	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026874	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026875	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		3341	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		6603851	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		933	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		939	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		985	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1160786	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1161520	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL588	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		DB00800	1628	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		1242	3613	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
		1242	3613	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
		935	3613	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
		935	3613	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
		CHEMBL286080	3613	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
		CHEMBL286080	3613	27	None	-5	18	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
		1712	2492	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		4078	2492	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		7227	2492	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		CHEMBL1088	2492	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		DB00933	2492	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		2274	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	3173	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1153	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		12668023	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		30026874	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		30026875	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		3341	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		6603851	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		933	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		939	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		985	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		CHEMBL1160786	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		CHEMBL1161520	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		CHEMBL588	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		DB00800	1628	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		1153	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		12668023	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026874	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026875	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		3341	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		6603851	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		933	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		939	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		985	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1160786	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1161520	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL588	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		DB00800	1628	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		1353	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		1353	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		3559	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		3559	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		86	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		86	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		CHEMBL54	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		CHEMBL54	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		DB00502	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		DB00502	1911	93	None	-38	83	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		5311070	1417	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		9267	1417	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		CHEMBL4280145	1417	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		DB12890	1417	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		2107	3055	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		4747	3055	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		9216	3055	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		CHEMBL251940	3055	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		DB01608	3055	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		13372	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		86764100	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		CHEMBL3697617	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		DB14899	3759	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		107930	1529	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		3304	1529	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		CHEMBL298406	1529	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		DB12273	1529	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		5018	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		5018	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		943	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		943	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		946	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		946	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		CHEMBL13668	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		CHEMBL13668	3549	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		1218	3616	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
		938	3616	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
		CHEMBL353335	3616	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
		6603703	208	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
		9637	208	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
		CHEMBL291143	208	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
		1243	3618	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
		944	3618	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
		CHEMBL324017	3618	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
		2995	204405	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	204405	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	204405	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		5770	205058	82	None	-2	7	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		CHEMBL772	205058	82	None	-2	7	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		213	3853	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	3853	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	3853	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	3853	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	3853	55	None	-12	44	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2601	3780	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	3780	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	3780	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	3780	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	3780	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		484	2858	51	None	-54	35	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
		951	2858	51	None	-54	35	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
		CHEMBL432	2858	51	None	-54	35	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
		2407	3372	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		59227	3372	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		941	3372	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		CHEMBL1303	3372	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		DB05271	3372	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		228	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		228	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		33	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		33	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		6005	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		6005	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		CHEMBL53	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		CHEMBL53	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		DB00714	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		DB00714	445	28	None	-35	24	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		3153	297	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
		3153	297	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
		932	297	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
		932	297	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
		CHEMBL26736	297	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
		CHEMBL26736	297	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
		2105	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		2105	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		47811	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		47811	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		48	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		48	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		CHEMBL531	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		CHEMBL531	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		DB01186	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		DB01186	3054	37	None	-537	33	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		31101	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		31101	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		35	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		35	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		403	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		403	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		CHEMBL493	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		CHEMBL493	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		DB01200	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		DB01200	729	40	None	-436	36	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		937	3615	0	None	-1	2	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1826762
		37	778	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		460	778	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		54746	778	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		CHEMBL1201087	778	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		DB00248	778	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		1524	2181	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		197	2181	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		3822	2181	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		88	2181	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		CHEMBL51	2181	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		DB12465	2181	96	None	-79	52	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		2470	3653	50	None	-4168	59	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		3300	3653	50	None	-4168	59	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		5265	3653	50	None	-4168	59	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		99	3653	50	None	-4168	59	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		CHEMBL267930	3653	50	None	-4168	59	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		135398737	958	93	None	-44	89	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		38	958	93	None	-44	89	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		722	958	93	None	-44	89	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		CHEMBL42	958	93	None	-44	89	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		DB00363	958	93	None	-44	89	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		100	3805	58	None	-47	55	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		2637	3805	58	None	-47	55	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		5452	3805	58	None	-47	55	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		CHEMBL479	3805	58	None	-47	55	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		DB00679	3805	58	None	-47	55	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		2726	919	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		621	919	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		83	919	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		CHEMBL71	919	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		DB00477	919	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		1588	2325	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		28864	2325	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		43	2325	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL157138	2325	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB00589	2325	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		30137	2877	0	None	-676	10	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
		8594	2877	0	None	-676	10	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
		934	2877	0	None	-676	10	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
		37459	746	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
		37459	746	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
		62	746	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
		62	746	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
		CHEMBL8514	746	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
		CHEMBL8514	746	13	None	-10	25	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
		1212	1662	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		204	1662	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		3372	1662	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		CHEMBL726	1662	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		DB00623	1662	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		173871	3614	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652
		936	3614	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652
		CHEMBL1193571	3614	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652

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Ligand source activities (1 row/activity)