Ligand source activities (1 row/activity)
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
11583188 | 138752 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 448 | 4 | 0 | 5 | 3.3 | COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL379125 | 138752 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 448 | 4 | 0 | 5 | 3.3 | COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1 | 10.1021/jm060166w | ||
44400674 | 124669 | 0 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL364516 | 124669 | 0 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
17449900 | 139012 | 12 | None | -2 | 3 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 348 | 5 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL379602 | 139012 | 12 | None | -2 | 3 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 348 | 5 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
16094675 | 81745 | 1 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 315 | 4 | 1 | 4 | 3.3 | Cc1cccc(NC(=O)CN2CCC(c3nccs3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL216922 | 81745 | 1 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 315 | 4 | 1 | 4 | 3.3 | Cc1cccc(NC(=O)CN2CCC(c3nccs3)CC2)c1 | 10.1021/jm060662k | ||
10359019 | 82912 | 5 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 326 | 4 | 1 | 2 | 4.0 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3F)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219129 | 82912 | 5 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 326 | 4 | 1 | 2 | 4.0 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3F)CC2)c1 | 10.1021/jm060662k | ||
10088259 | 101443 | 3 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1021/jm970021c | ||
CHEMBL300956 | 101443 | 3 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1021/jm970021c | ||
44400585 | 68313 | 0 | None | 2 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL191962 | 68313 | 0 | None | 2 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm060166w | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm060166w | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm060166w | ||
11725531 | 53769 | 1 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 351 | 3 | 0 | 5 | 3.2 | N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160626 | 53769 | 1 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 351 | 3 | 0 | 5 | 3.2 | N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
6469918 | 79481 | 13 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL212370 | 79481 | 13 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
681 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | ||
940 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | ||
947 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | ||
CHEMBL59 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | ||
DB00988 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | ||
155559617 | 174312 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4563944 | 174312 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
44400585 | 68313 | 0 | None | 2 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL191962 | 68313 | 0 | None | 2 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
10378194 | 196088 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 265 | 3 | 1 | 2 | 2.3 | C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL57176 | 196088 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 265 | 3 | 1 | 2 | 2.3 | C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
681 | 1437 | 65 | None | -7 | 12 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm0604979 | ||
940 | 1437 | 65 | None | -7 | 12 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm0604979 | ||
947 | 1437 | 65 | None | -7 | 12 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm0604979 | ||
CHEMBL59 | 1437 | 65 | None | -7 | 12 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm0604979 | ||
DB00988 | 1437 | 65 | None | -7 | 12 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm0604979 | ||
10383724 | 82998 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 357 | 5 | 1 | 4 | 2.9 | CSc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219570 | 82998 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 357 | 5 | 1 | 4 | 2.9 | CSc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
16094681 | 82934 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(F)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL219261 | 82934 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(F)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
16094684 | 136077 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 4 | 1 | 3 | 2.4 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccc(F)cc1F | 10.1021/jm060662k | ||
CHEMBL373964 | 136077 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 347 | 4 | 1 | 3 | 2.4 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccc(F)cc1F | 10.1021/jm060662k | ||
10065188 | 101133 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1021/jm970021c | ||
CHEMBL298763 | 101133 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1021/jm970021c | ||
155568867 | 175580 | 0 | None | -3 | 3 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4592753 | 175580 | 0 | None | -3 | 3 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
11221906 | 79501 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(C)c(C)c1 | 10.1021/jm060279f | ||
CHEMBL212444 | 79501 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(C)c(C)c1 | 10.1021/jm060279f | ||
155536720 | 171621 | 0 | None | 37 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473652 | 171621 | 0 | None | 37 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
11849262 | 79707 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 337 | 7 | 0 | 4 | 3.6 | CCO/N=C(\CCN1CCN(c2ccccc2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL213246 | 79707 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 337 | 7 | 0 | 4 | 3.6 | CCO/N=C(\CCN1CCN(c2ccccc2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmcl.2006.02.075 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmcl.2006.02.075 | ||
11849223 | 79437 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL212189 | 79437 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
25142456 | 81994 | 2 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 | 10.1021/jm0604979 | ||
CHEMBL217299 | 81994 | 2 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 | 10.1021/jm0604979 | ||
44418745 | 82997 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 337 | 5 | 1 | 3 | 3.8 | CCc1cccc(C)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
CHEMBL219567 | 82997 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 337 | 5 | 1 | 3 | 3.8 | CCc1cccc(C)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
11325818 | 79378 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL211930 | 79378 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
10428669 | 83052 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 361 | 4 | 1 | 3 | 3.0 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc2ccccc2c1 | 10.1021/jm060662k | ||
CHEMBL220015 | 83052 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 361 | 4 | 1 | 3 | 3.0 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc2ccccc2c1 | 10.1021/jm060662k | ||
9835713 | 18300 | 1 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 292 | 3 | 1 | 3 | 3.3 | c1ccc(C2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
CHEMBL127226 | 18300 | 1 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 292 | 3 | 1 | 3 | 3.3 | c1ccc(C2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
10404144 | 203591 | 19 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL7927 | 203591 | 19 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
10361512 | 54154 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 365 | 3 | 0 | 5 | 3.5 | Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160932 | 54154 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 365 | 3 | 0 | 5 | 3.5 | Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
168285560 | 192316 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196873 | 192316 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222201 | 192316 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
5025739 | 168630 | 40 | None | 1 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
CHEMBL440687 | 168630 | 40 | None | 1 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
44414898 | 138377 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 341 | 6 | 1 | 7 | 1.0 | CO/N=C(/c1cccnc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL378302 | 138377 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 341 | 6 | 1 | 7 | 1.0 | CO/N=C(/c1cccnc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
10316440 | 141134 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 3.1 | Cc1ccc(Cl)cc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL385417 | 141134 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 3.1 | Cc1ccc(Cl)cc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
16094706 | 141377 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 346 | 4 | 1 | 4 | 1.9 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1cnccc1Cl | 10.1021/jm060662k | ||
CHEMBL386917 | 141377 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 346 | 4 | 1 | 4 | 1.9 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1cnccc1Cl | 10.1021/jm060662k | ||
10382581 | 100828 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm970021c | ||
CHEMBL296506 | 100828 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm970021c | ||
44400626 | 70059 | 0 | None | -2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL194555 | 70059 | 0 | None | -2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
11849638 | 79604 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 335 | 5 | 1 | 6 | 2.3 | N#Cc1cccc(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
CHEMBL212847 | 79604 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 335 | 5 | 1 | 6 | 2.3 | N#Cc1cccc(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
11772242 | 165734 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL427048 | 165734 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
9861462 | 82921 | 0 | None | -5 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 309 | 3 | 2 | 5 | 2.0 | Oc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
CHEMBL219179 | 82921 | 0 | None | -5 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 309 | 3 | 2 | 5 | 2.0 | Oc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
5025739 | 168630 | 40 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
CHEMBL440687 | 168630 | 40 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
16094682 | 83066 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 370 | 5 | 1 | 5 | 2.4 | Cc1ccc([N+](=O)[O-])cc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL220139 | 83066 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 370 | 5 | 1 | 5 | 2.4 | Cc1ccc([N+](=O)[O-])cc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
11280225 | 80684 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.6 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(C)c1 | 10.1021/jm060279f | ||
CHEMBL215569 | 80684 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.6 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(C)c1 | 10.1021/jm060279f | ||
10430781 | 82865 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 395 | 5 | 1 | 4 | 3.0 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(OC(F)(F)F)c1 | 10.1021/jm060662k | ||
CHEMBL218852 | 82865 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 395 | 5 | 1 | 4 | 3.0 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(OC(F)(F)F)c1 | 10.1021/jm060662k | ||
11849734 | 79742 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 363 | 7 | 0 | 6 | 2.9 | CCO/N=C(\CCN1CCN(c2ncccc2C#N)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL213398 | 79742 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 363 | 7 | 0 | 6 | 2.9 | CCO/N=C(\CCN1CCN(c2ncccc2C#N)CC1)c1ccccc1 | 10.1021/jm060279f | ||
10425450 | 199 | 23 | None | 125 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/jm060662k | ||
3301 | 199 | 23 | None | 125 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/jm060662k | ||
CHEMBL375596 | 199 | 23 | None | 125 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/jm060662k | ||
44400519 | 132608 | 0 | None | -2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL370297 | 132608 | 0 | None | -2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
681 | 1437 | 65 | None | -7 | 12 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
940 | 1437 | 65 | None | -7 | 12 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
947 | 1437 | 65 | None | -7 | 12 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL59 | 1437 | 65 | None | -7 | 12 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
DB00988 | 1437 | 65 | None | -7 | 12 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
16094672 | 82856 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 397 | 4 | 1 | 3 | 4.9 | O=C(CN1CCC(c2ccccn2)CC1)Nc1c(Cl)cc(Cl)cc1Cl | 10.1021/jm060662k | ||
CHEMBL218797 | 82856 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 397 | 4 | 1 | 3 | 4.9 | O=C(CN1CCC(c2ccccn2)CC1)Nc1c(Cl)cc(Cl)cc1Cl | 10.1021/jm060662k | ||
11451703 | 138489 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 376 | 6 | 0 | 5 | 3.4 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL378576 | 138489 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 376 | 6 | 0 | 5 | 3.4 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060279f | ||
10642239 | 186077 | 1 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
CHEMBL48819 | 186077 | 1 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
119570 | 3110 | 90 | None | -11 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
2233 | 3110 | 90 | None | -11 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
953 | 3110 | 90 | None | -11 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL301265 | 3110 | 90 | None | -11 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
DB00413 | 3110 | 90 | None | -11 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
16094666 | 81315 | 2 | None | 251 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL216393 | 81315 | 2 | None | 251 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10022369 | 83075 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 375 | 5 | 1 | 4 | 2.5 | COc1cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)ccc1Cl | 10.1021/jm060662k | ||
CHEMBL220192 | 83075 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 375 | 5 | 1 | 4 | 2.5 | COc1cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)ccc1Cl | 10.1021/jm060662k | ||
10665101 | 101055 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1021/jm970021c | ||
CHEMBL298166 | 101055 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1021/jm970021c | ||
10404144 | 203591 | 19 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL7927 | 203591 | 19 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
168268756 | 192162 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5171439 | 192162 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221187 | 192162 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
16094678 | 82972 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(F)c1 | 10.1021/jm060662k | ||
CHEMBL219417 | 82972 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(F)c1 | 10.1021/jm060662k | ||
10045314 | 165430 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.4 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cc(Cl)cc(Cl)c1 | 10.1021/jm060662k | ||
CHEMBL425288 | 165430 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.4 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cc(Cl)cc(Cl)c1 | 10.1021/jm060662k | ||
11175610 | 137597 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 352 | 7 | 0 | 5 | 3.4 | CC(C)O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL376639 | 137597 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 352 | 7 | 0 | 5 | 3.4 | CC(C)O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
6603820 | 95330 | 13 | None | -1 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | 10.1021/jm0604979 | ||
CHEMBL25856 | 95330 | 13 | None | -1 | 7 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | 10.1021/jm0604979 | ||
3645619 | 2985 | 13 | None | -1 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm970021c | ||
975 | 2985 | 13 | None | -1 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm970021c | ||
CHEMBL45244 | 2985 | 13 | None | -1 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm970021c | ||
1353 | 1880 | 85 | None | -7 | 27 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(03)00587-0 | ||
3559 | 1880 | 85 | None | -7 | 27 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(03)00587-0 | ||
86 | 1880 | 85 | None | -7 | 27 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL54 | 1880 | 85 | None | -7 | 27 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(03)00587-0 | ||
DB00502 | 1880 | 85 | None | -7 | 27 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(03)00587-0 | ||
11849636 | 79436 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 328 | 5 | 1 | 5 | 2.6 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
CHEMBL212188 | 79436 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 328 | 5 | 1 | 5 | 2.6 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
11849225 | 79769 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 2.8 | O/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
CHEMBL213518 | 79769 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 2.8 | O/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
16094666 | 81315 | 2 | None | 251 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL216393 | 81315 | 2 | None | 251 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/jm060662k | ||
16094705 | 82951 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 429 | 5 | 1 | 4 | 3.4 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(OC(F)(F)F)c(Cl)c1 | 10.1021/jm060662k | ||
CHEMBL219340 | 82951 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 429 | 5 | 1 | 4 | 3.4 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(OC(F)(F)F)c(Cl)c1 | 10.1021/jm060662k | ||
11325645 | 138148 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(C)cc(C)c1 | 10.1021/jm060279f | ||
CHEMBL377794 | 138148 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(C)cc(C)c1 | 10.1021/jm060279f | ||
44415054 | 80717 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 335 | 5 | 1 | 6 | 2.3 | N#Cc1cccnc1N1CCN(CC/C(=N\O)c2ccccc2)CC1 | 10.1021/jm060279f | ||
CHEMBL215670 | 80717 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 335 | 5 | 1 | 6 | 2.3 | N#Cc1cccnc1N1CCN(CC/C(=N\O)c2ccccc2)CC1 | 10.1021/jm060279f | ||
9997550 | 136076 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)ccc1F | 10.1021/jm060662k | ||
CHEMBL373963 | 136076 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)ccc1F | 10.1021/jm060662k | ||
10339711 | 82994 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.4 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(Cl)c1Cl | 10.1021/jm060662k | ||
CHEMBL219564 | 82994 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.4 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(Cl)c1Cl | 10.1021/jm060662k | ||
11849777 | 138103 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 6 | 0 | 5 | 3.4 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Br)cc1 | 10.1021/jm060279f | ||
CHEMBL377585 | 138103 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 6 | 0 | 5 | 3.4 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Br)cc1 | 10.1021/jm060279f | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm050170s | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm050170s | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm050170s | ||
135407844 | 79674 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 340 | 5 | 2 | 6 | 2.5 | Cc1ccc(O)c(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
CHEMBL213106 | 79674 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 340 | 5 | 2 | 6 | 2.5 | Cc1ccc(O)c(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
11849639 | 79947 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 2.8 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
CHEMBL214343 | 79947 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 2.8 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
11849816 | 77725 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(\CCN1CCC(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL210101 | 77725 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(\CCN1CCC(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
11849822 | 79699 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 388 | 7 | 0 | 6 | 2.9 | CO/N=C(\c1ccc(Cl)cc1)C(CN1CCN(c2ccccn2)CC1)OC | 10.1021/jm060279f | ||
CHEMBL213208 | 79699 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 388 | 7 | 0 | 6 | 2.9 | CO/N=C(\c1ccc(Cl)cc1)C(CN1CCN(c2ccccn2)CC1)OC | 10.1021/jm060279f | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00814-9 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00814-9 | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acs.jmedchem.9b01085 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acs.jmedchem.9b01085 | ||
681 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
940 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
947 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
CHEMBL59 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
DB00988 | 1437 | 65 | None | -7 | 12 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(02)00316-5 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(02)00316-5 | ||
11849637 | 79463 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 324 | 5 | 1 | 5 | 2.8 | Cc1cccc(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
CHEMBL212298 | 79463 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 324 | 5 | 1 | 5 | 2.8 | Cc1cccc(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
9861462 | 82921 | 0 | None | 5 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 309 | 3 | 2 | 5 | 2.0 | Oc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
CHEMBL219179 | 82921 | 0 | None | 5 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 309 | 3 | 2 | 5 | 2.0 | Oc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
681 | 1437 | 65 | None | -1 | 12 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
940 | 1437 | 65 | None | -1 | 12 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
947 | 1437 | 65 | None | -1 | 12 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
CHEMBL59 | 1437 | 65 | None | -1 | 12 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
DB00988 | 1437 | 65 | None | -1 | 12 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm060662k | ||
44400674 | 124669 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL364516 | 124669 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
6469918 | 79481 | 13 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL212370 | 79481 | 13 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acsmedchemlett.9b00050 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acsmedchemlett.9b00050 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acsmedchemlett.9b00050 | ||
10425450 | 199 | 23 | None | 125 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
3301 | 199 | 23 | None | 125 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL375596 | 199 | 23 | None | 125 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
11439072 | 168393 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 335 | 5 | 1 | 6 | 2.3 | N#Cc1cccnc1N1CCN(CC/C(=N/O)c2ccccc2)CC1 | 10.1021/jm060279f | ||
CHEMBL438961 | 168393 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 335 | 5 | 1 | 6 | 2.3 | N#Cc1cccnc1N1CCN(CC/C(=N/O)c2ccccc2)CC1 | 10.1021/jm060279f | ||
11849635 | 79969 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 324 | 5 | 1 | 5 | 2.8 | Cc1ccccc1/C(CCN1CCN(c2ccccn2)CC1)=N\O | 10.1021/jm060279f | ||
CHEMBL214440 | 79969 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 324 | 5 | 1 | 5 | 2.8 | Cc1ccccc1/C(CCN1CCN(c2ccccn2)CC1)=N\O | 10.1021/jm060279f | ||
681 | 1437 | 65 | None | -7 | 12 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
940 | 1437 | 65 | None | -7 | 12 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
947 | 1437 | 65 | None | -7 | 12 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL59 | 1437 | 65 | None | -7 | 12 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
DB00988 | 1437 | 65 | None | -7 | 12 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
11849182 | 79459 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 2.7 | CO/N=C(/c1ccc(Cl)cc1)C(CNOC)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL212288 | 79459 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 2.7 | CO/N=C(/c1ccc(Cl)cc1)C(CNOC)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
16094698 | 137343 | 4 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 338 | 5 | 1 | 3 | 3.6 | COc1ccccc1C1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm060662k | ||
CHEMBL376092 | 137343 | 4 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 338 | 5 | 1 | 3 | 3.6 | COc1ccccc1C1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm060662k | ||
44417647 | 81749 | 0 | None | 52 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 311 | 2 | 2 | 4 | 3.2 | CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21 | 10.1021/jm0604979 | ||
CHEMBL1203924 | 81749 | 0 | None | 52 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 311 | 2 | 2 | 4 | 3.2 | CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21 | 10.1021/jm0604979 | ||
CHEMBL216945 | 81749 | 0 | None | 52 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 311 | 2 | 2 | 4 | 3.2 | CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21 | 10.1021/jm0604979 | ||
11301354 | 141116 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 310 | 5 | 1 | 5 | 2.5 | O/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL385350 | 141116 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 310 | 5 | 1 | 5 | 2.5 | O/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
10617381 | 189094 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm970021c | ||
CHEMBL51536 | 189094 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm970021c | ||
44400553 | 70435 | 0 | None | -2 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL195083 | 70435 | 0 | None | -2 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
11849821 | 168734 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(/c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL441529 | 168734 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(/c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
44400553 | 70435 | 0 | None | -2 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL195083 | 70435 | 0 | None | -2 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
2 | 3210 | 19 | None | -2 | 7 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmcl.2006.02.075 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmcl.2006.02.075 | ||
24878061 | 140879 | 0 | None | 4 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2 | 10.1021/jm0604979 | ||
CHEMBL384046 | 140879 | 0 | None | 4 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2 | 10.1021/jm0604979 | ||
11849633 | 80166 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
CHEMBL214954 | 80166 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
9883554 | 164802 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
CHEMBL423659 | 164802 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
11163137 | 141205 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 6 | 0 | 5 | 2.6 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL385826 | 141205 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 6 | 0 | 5 | 2.6 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
16094671 | 82964 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 357 | 4 | 1 | 3 | 4.2 | Cc1cc(Cl)cc(C)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
CHEMBL219392 | 82964 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 357 | 4 | 1 | 3 | 4.2 | Cc1cc(Cl)cc(C)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
10338536 | 81722 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 2.8 | Cc1cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)ccc1Cl | 10.1021/jm060662k | ||
CHEMBL216721 | 81722 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 2.8 | Cc1cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)ccc1Cl | 10.1021/jm060662k | ||
11269392 | 77656 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1Cl | 10.1021/jm060279f | ||
CHEMBL209759 | 77656 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1Cl | 10.1021/jm060279f | ||
11849634 | 141091 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
CHEMBL385230 | 141091 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
11849265 | 139010 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 352 | 7 | 0 | 5 | 3.3 | CCO/N=C(\CCN1CCN(c2ncccc2C)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL379597 | 139010 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 352 | 7 | 0 | 5 | 3.3 | CCO/N=C(\CCN1CCN(c2ncccc2C)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11738945 | 79537 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 328 | 5 | 0 | 5 | 2.4 | CO/N=C(/CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL212595 | 79537 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 328 | 5 | 0 | 5 | 2.4 | CO/N=C(/CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
2653640 | 65887 | 12 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184486 | 65887 | 12 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1016/j.bmcl.2004.07.068 | ||
11849263 | 160390 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 367 | 8 | 0 | 5 | 3.6 | CCO/N=C(\CCN1CCN(c2cccc(OC)c2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL411545 | 160390 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 367 | 8 | 0 | 5 | 3.6 | CCO/N=C(\CCN1CCN(c2cccc(OC)c2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
681 | 1437 | 65 | None | -7 | 12 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
940 | 1437 | 65 | None | -7 | 12 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
947 | 1437 | 65 | None | -7 | 12 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL59 | 1437 | 65 | None | -7 | 12 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
DB00988 | 1437 | 65 | None | -7 | 12 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.2c00840 | ||
3303 | 2213 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00814-9 | ||
5311200 | 2213 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00814-9 | ||
11849776 | 79362 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 349 | 6 | 0 | 6 | 2.5 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C#N)c1 | 10.1021/jm060279f | ||
CHEMBL211836 | 79362 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 349 | 6 | 0 | 6 | 2.5 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C#N)c1 | 10.1021/jm060279f | ||
11739255 | 79608 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
CHEMBL212861 | 79608 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
10042205 | 136423 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccccc1F | 10.1021/jm060662k | ||
CHEMBL374326 | 136423 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccccc1F | 10.1021/jm060662k | ||
11256262 | 79591 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 338 | 7 | 0 | 5 | 3.0 | CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL212782 | 79591 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 338 | 7 | 0 | 5 | 3.0 | CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
45361874 | 169454 | 2 | None | 58 | 3 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4442548 | 169454 | 2 | None | 58 | 3 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
11474734 | 79515 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 388 | 7 | 0 | 6 | 2.9 | CO/N=C(/c1ccc(Cl)cc1)C(CN1CCN(c2ccccn2)CC1)OC | 10.1021/jm060279f | ||
CHEMBL212490 | 79515 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 388 | 7 | 0 | 6 | 2.9 | CO/N=C(/c1ccc(Cl)cc1)C(CN1CCN(c2ccccn2)CC1)OC | 10.1021/jm060279f | ||
16094685 | 83218 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 1.9 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)NC1CCCCC1 | 10.1021/jm060662k | ||
CHEMBL220469 | 83218 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 1.9 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)NC1CCCCC1 | 10.1021/jm060662k | ||
11292299 | 79360 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1Cl | 10.1021/jm060279f | ||
CHEMBL211829 | 79360 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1Cl | 10.1021/jm060279f | ||
6469693 | 79545 | 17 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL212631 | 79545 | 17 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1021/jm060166w | ||
10593191 | 188519 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1021/jm970021c | ||
CHEMBL51023 | 188519 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1021/jm970021c | ||
6466372 | 169495 | 12 | None | 58 | 3 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443054 | 169495 | 12 | None | 58 | 3 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
4797946 | 169856 | 8 | None | 81 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4448320 | 169856 | 8 | None | 81 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
16094704 | 81744 | 1 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 325 | 4 | 2 | 4 | 2.9 | Cc1cccc(NC(=O)CN2CCC(c3ccc(O)cn3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL216921 | 81744 | 1 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 325 | 4 | 2 | 4 | 2.9 | Cc1cccc(NC(=O)CN2CCC(c3ccc(O)cn3)CC2)c1 | 10.1021/jm060662k | ||
11849224 | 79623 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 328 | 5 | 1 | 5 | 2.6 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL212902 | 79623 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 328 | 5 | 1 | 5 | 2.6 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
10616050 | 186064 | 3 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
CHEMBL48807 | 186064 | 3 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
10247720 | 12943 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL1190042 | 12943 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL540039 | 12943 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
10018402 | 81721 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 312 | 4 | 1 | 4 | 1.3 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccccn1 | 10.1021/jm060662k | ||
CHEMBL216719 | 81721 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 312 | 4 | 1 | 4 | 1.3 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccccn1 | 10.1021/jm060662k | ||
11324794 | 137731 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 324 | 6 | 0 | 5 | 2.6 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL377050 | 137731 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 324 | 6 | 0 | 5 | 2.6 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
16094677 | 82923 | 0 | None | 1 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.4 | Cc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219185 | 82923 | 0 | None | 1 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.4 | Cc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
11198974 | 79600 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 352 | 8 | 0 | 5 | 3.4 | CCCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL212831 | 79600 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 352 | 8 | 0 | 5 | 3.4 | CCCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11849299 | 78985 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 430 | 9 | 0 | 6 | 3.9 | CO/N=C(/c1ccc(Cl)cc1)C(COC(C)C)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL211360 | 78985 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 430 | 9 | 0 | 6 | 3.9 | CO/N=C(/c1ccc(Cl)cc1)C(COC(C)C)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
10405923 | 82990 | 3 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 355 | 6 | 1 | 4 | 2.3 | CCOc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219551 | 82990 | 3 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 355 | 6 | 1 | 4 | 2.3 | CCOc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
11849229 | 137646 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 349 | 7 | 0 | 6 | 2.5 | N#CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL376955 | 137646 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 349 | 7 | 0 | 6 | 2.5 | N#CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11370781 | 79461 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 325 | 6 | 0 | 6 | 2.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccnc1 | 10.1021/jm060279f | ||
CHEMBL212291 | 79461 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 325 | 6 | 0 | 6 | 2.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccnc1 | 10.1021/jm060279f | ||
11849820 | 77600 | 0 | None | 10 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 356 | 7 | 0 | 5 | 3.2 | CO/N=C(/CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL209645 | 77600 | 0 | None | 10 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 356 | 7 | 0 | 5 | 3.2 | CO/N=C(/CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
11849267 | 79462 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.7 | CO/N=C(\CCN1CCN(c2ccccn2)CC1C)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL212292 | 79462 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.7 | CO/N=C(\CCN1CCN(c2ccccn2)CC1C)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
11849730 | 79539 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 367 | 8 | 0 | 5 | 3.6 | CCO/N=C(\CCN1CCN(c2ccccc2OC)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL212607 | 79539 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 367 | 8 | 0 | 5 | 3.6 | CCO/N=C(\CCN1CCN(c2ccccc2OC)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11849180 | 79398 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 354 | 6 | 1 | 6 | 2.4 | COC(CN1CCN(c2ccccn2)CC1)/C(=N\O)c1cccc(C)c1 | 10.1021/jm060279f | ||
CHEMBL212028 | 79398 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 354 | 6 | 1 | 6 | 2.4 | COC(CN1CCN(c2ccccn2)CC1)/C(=N\O)c1cccc(C)c1 | 10.1021/jm060279f | ||
16094668 | 82913 | 3 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3C)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219130 | 82913 | 3 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3C)CC2)c1 | 10.1021/jm060662k | ||
10405922 | 82995 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 355 | 5 | 1 | 4 | 2.5 | COc1cccc(C)c1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL219565 | 82995 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 355 | 5 | 1 | 4 | 2.5 | COc1cccc(C)c1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
11849780 | 79773 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL213558 | 79773 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm060279f | ||
16094683 | 137347 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 3.8 | Cc1ccc(Cl)c(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1Cl | 10.1021/jm060662k | ||
CHEMBL376196 | 137347 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 3.8 | Cc1ccc(Cl)c(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1Cl | 10.1021/jm060662k | ||
10042826 | 165586 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.8 | Cc1cccc(C)c1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL426167 | 165586 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.8 | Cc1cccc(C)c1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
44415055 | 80729 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 381 | 9 | 0 | 5 | 4.0 | CCO/N=C(\CCN1CCN(c2cccc(OCC)c2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL215704 | 80729 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 381 | 9 | 0 | 5 | 4.0 | CCO/N=C(\CCN1CCN(c2cccc(OCC)c2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
155530763 | 171003 | 0 | None | -2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4464861 | 171003 | 0 | None | -2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
44400519 | 132608 | 0 | None | -2 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL370297 | 132608 | 0 | None | -2 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
11849684 | 79805 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 350 | 8 | 0 | 5 | 3.2 | C=CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL213700 | 79805 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 350 | 8 | 0 | 5 | 3.2 | C=CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
16094674 | 141135 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 3.1 | Cc1cccc(NC(=O)CN2CCC(c3cccc(C#N)n3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL385418 | 141135 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 3.1 | Cc1cccc(NC(=O)CN2CCC(c3cccc(C#N)n3)CC2)c1 | 10.1021/jm060662k | ||
16094708 | 165520 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 387 | 5 | 1 | 3 | 3.8 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(-c2ccccc2)c1 | 10.1021/jm060662k | ||
CHEMBL425793 | 165520 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 387 | 5 | 1 | 3 | 3.8 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(-c2ccccc2)c1 | 10.1021/jm060662k | ||
11164276 | 79342 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
CHEMBL211732 | 79342 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
11199162 | 79449 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL212235 | 79449 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
10404935 | 82996 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.5 | Cc1ccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)cc1C | 10.1021/jm060662k | ||
CHEMBL219566 | 82996 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.5 | Cc1ccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)cc1C | 10.1021/jm060662k | ||
11849228 | 95969 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 366 | 9 | 0 | 5 | 3.8 | CCCCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL261957 | 95969 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 366 | 9 | 0 | 5 | 3.8 | CCCCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11151081 | 79385 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 311 | 5 | 1 | 6 | 1.9 | O/N=C(\CCN1CCN(c2ncccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL211972 | 79385 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 311 | 5 | 1 | 6 | 1.9 | O/N=C(\CCN1CCN(c2ncccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11849222 | 80807 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 324 | 5 | 1 | 5 | 2.8 | Cc1ccccc1/C(CCN1CCN(c2ccccn2)CC1)=N/O | 10.1021/jm060279f | ||
CHEMBL215849 | 80807 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 324 | 5 | 1 | 5 | 2.8 | Cc1ccccc1/C(CCN1CCN(c2ccccn2)CC1)=N/O | 10.1021/jm060279f | ||
228 | 441 | 26 | None | -1 | 8 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
33 | 441 | 26 | None | -1 | 8 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
6005 | 441 | 26 | None | -1 | 8 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
CHEMBL53 | 441 | 26 | None | -1 | 8 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
DB00714 | 441 | 26 | None | -1 | 8 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
11185987 | 79938 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 310 | 5 | 1 | 5 | 2.5 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL214314 | 79938 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 310 | 5 | 1 | 5 | 2.5 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
6469693 | 79545 | 17 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL212631 | 79545 | 17 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1021/jm060166w | ||
11849179 | 80733 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 340 | 5 | 2 | 6 | 1.8 | Cc1cccc(/C(=N/O)C(O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm060279f | ||
CHEMBL215723 | 80733 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 340 | 5 | 2 | 6 | 1.8 | Cc1cccc(/C(=N/O)C(O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm060279f | ||
44418748 | 169891 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 3.2 | COc1cccc(C)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
CHEMBL444881 | 169891 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 3.2 | COc1cccc(C)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
11450607 | 79762 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1C | 10.1021/jm060279f | ||
CHEMBL213486 | 79762 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1C | 10.1021/jm060279f | ||
155552185 | 173489 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4544086 | 173489 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
11849819 | 79836 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 7 | 0 | 5 | 3.2 | CO/N=C(\CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL213828 | 79836 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 7 | 0 | 5 | 3.2 | CO/N=C(\CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
11371795 | 79410 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
CHEMBL212073 | 79410 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
10472323 | 82846 | 4 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 338 | 5 | 1 | 3 | 3.8 | COc1ccccc1C1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1021/jm060662k | ||
CHEMBL218761 | 82846 | 4 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 338 | 5 | 1 | 3 | 3.8 | COc1ccccc1C1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1021/jm060662k | ||
11849817 | 138401 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 314 | 4 | 1 | 5 | 2.2 | O/N=C(\CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL378427 | 138401 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 314 | 4 | 1 | 5 | 2.2 | O/N=C(\CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
11771801 | 79619 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 328 | 5 | 0 | 5 | 2.4 | CO/N=C(\CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL212891 | 79619 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 328 | 5 | 0 | 5 | 2.4 | CO/N=C(\CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
10084583 | 104299 | 3 | None | -151 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 271 | 5 | 0 | 3 | 3.3 | CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL310867 | 104299 | 3 | None | -151 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 271 | 5 | 0 | 3 | 3.3 | CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 | 10.1016/s0960-894x(02)00390-6 | ||
11849775 | 165643 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
CHEMBL426510 | 165643 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
11849823 | 79195 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 340 | 5 | 2 | 6 | 1.8 | Cc1cccc(/C(=N\O)C(O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm060279f | ||
CHEMBL211463 | 79195 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 340 | 5 | 2 | 6 | 1.8 | Cc1cccc(/C(=N\O)C(O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm060279f | ||
11151919 | 79776 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 338 | 7 | 0 | 5 | 3.0 | CCO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL213572 | 79776 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 338 | 7 | 0 | 5 | 3.0 | CCO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
10385089 | 141198 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.2 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1cc(Cl)cc(Cl)c1 | 10.1021/jm060662k | ||
CHEMBL385781 | 141198 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.2 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1cc(Cl)cc(Cl)c1 | 10.1021/jm060662k | ||
11849681 | 79391 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | Cc1cc(C)cc(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
CHEMBL211985 | 79391 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | Cc1cc(C)cc(/C(CCN2CCN(c3ccccn3)CC2)=N/O)c1 | 10.1021/jm060279f | ||
11849181 | 79650 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | CO/N=C(/c1ccc(Cl)cc1)C(C)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL213004 | 79650 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | CO/N=C(/c1ccc(Cl)cc1)C(C)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
11211058 | 79924 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(\c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL214247 | 79924 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(\c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
11187957 | 139000 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 373 | 6 | 0 | 4 | 3.6 | CO/N=C(/CCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL379546 | 139000 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 373 | 6 | 0 | 4 | 3.6 | CO/N=C(/CCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
11849778 | 80730 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
CHEMBL215705 | 80730 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
16094709 | 82922 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 397 | 4 | 1 | 3 | 3.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccc(F)cc1C(F)(F)F | 10.1021/jm060662k | ||
CHEMBL219181 | 82922 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 397 | 4 | 1 | 3 | 3.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccc(F)cc1C(F)(F)F | 10.1021/jm060662k | ||
11473427 | 140975 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL384529 | 140975 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 344 | 5 | 1 | 5 | 3.1 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
11849184 | 79622 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 364 | 5 | 0 | 5 | 3.2 | CCO/N=C1/c2ccccc2CCC1CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL212901 | 79622 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 364 | 5 | 0 | 5 | 3.2 | CCO/N=C1/c2ccccc2CCC1CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
11849729 | 141370 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 362 | 7 | 0 | 5 | 3.5 | CCO/N=C(\CCN1CCN(c2ccccc2C#N)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL386867 | 141370 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 362 | 7 | 0 | 5 | 3.5 | CCO/N=C(\CCN1CCN(c2ccccc2C#N)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11325334 | 79641 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL212969 | 79641 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm060166w | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm060166w | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm060166w | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm050170s | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm050170s | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm050170s | ||
3038495 | 700 | 30 | None | -91 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm050170s | ||
7625 | 700 | 30 | None | -91 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm050170s | ||
CHEMBL25236 | 700 | 30 | None | -91 | 7 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm050170s | ||
11849688 | 79527 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 316 | 5 | 1 | 6 | 2.5 | O/N=C(\CCN1CCN(c2nccs2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL212545 | 79527 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 316 | 5 | 1 | 6 | 2.5 | O/N=C(\CCN1CCN(c2nccs2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
2 | 3210 | 19 | None | -2 | 7 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0604979 | ||
54562 | 3210 | 19 | None | -2 | 7 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0604979 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 7 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0604979 | ||
9975465 | 187068 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
CHEMBL49502 | 187068 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
228 | 441 | 26 | None | 1 | 8 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
33 | 441 | 26 | None | 1 | 8 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
6005 | 441 | 26 | None | 1 | 8 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
CHEMBL53 | 441 | 26 | None | 1 | 8 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
DB00714 | 441 | 26 | None | 1 | 8 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
44301054 | 194474 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL56118 | 194474 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
11983282 | 138414 | 0 | None | -2 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 315 | 4 | 0 | 3 | 4.2 | C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL378455 | 138414 | 0 | None | -2 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 315 | 4 | 0 | 3 | 4.2 | C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
10088811 | 82924 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.3 | Cc1cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)ccc1F | 10.1021/jm060662k | ||
CHEMBL219186 | 82924 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.3 | Cc1cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)ccc1F | 10.1021/jm060662k | ||
168285556 | 192315 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196870 | 192315 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222200 | 192315 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
10064956 | 135863 | 5 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 326 | 4 | 1 | 2 | 4.0 | Cc1cccc(NC(=O)CN2CCC(c3cccc(F)c3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL373516 | 135863 | 5 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 326 | 4 | 1 | 2 | 4.0 | Cc1cccc(NC(=O)CN2CCC(c3cccc(F)c3)CC2)c1 | 10.1021/jm060662k | ||
10020098 | 82927 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.8 | Cc1cc(C)cc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219210 | 82927 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.8 | Cc1cc(C)cc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
10335627 | 82974 | 3 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 311 | 4 | 1 | 3 | 1.9 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccccc1 | 10.1021/jm060662k | ||
CHEMBL219426 | 82974 | 3 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 311 | 4 | 1 | 3 | 1.9 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccccc1 | 10.1021/jm060662k | ||
11849298 | 79324 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 354 | 6 | 1 | 6 | 2.4 | COC(CN1CCN(c2ccccn2)CC1)/C(=N/O)c1cccc(C)c1 | 10.1021/jm060279f | ||
CHEMBL211623 | 79324 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 354 | 6 | 1 | 6 | 2.4 | COC(CN1CCN(c2ccccn2)CC1)/C(=N/O)c1cccc(C)c1 | 10.1021/jm060279f | ||
155513053 | 169131 | 0 | None | 23 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4437912 | 169131 | 0 | None | 23 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
16094697 | 136704 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 308 | 3 | 1 | 3 | 2.6 | [O-][n+]1ccccc1C1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm060662k | ||
CHEMBL375120 | 136704 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 308 | 3 | 1 | 3 | 2.6 | [O-][n+]1ccccc1C1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm060662k | ||
11200205 | 138382 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL378324 | 138382 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm060279f | ||
16094679 | 82864 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 369 | 6 | 1 | 4 | 2.9 | CC(C)Oc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL218851 | 82864 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 369 | 6 | 1 | 4 | 2.9 | CC(C)Oc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
11314352 | 79450 | 1 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL212236 | 79450 | 1 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
109030515 | 175412 | 1 | None | 14 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4588808 | 175412 | 1 | None | 14 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
16094677 | 82923 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.4 | Cc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219185 | 82923 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.4 | Cc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
11849774 | 79460 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
CHEMBL212290 | 79460 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccccc1Cl | 10.1021/jm060279f | ||
11849269 | 79142 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 6 | 1 | 5 | 3.0 | O/N=C(/CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL211415 | 79142 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 6 | 1 | 5 | 3.0 | O/N=C(/CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
71452737 | 78681 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 399 | 8 | 0 | 5 | 4.2 | CO/N=C(\CCN1CCN(c2ccccc2OC(C)C)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL2113243 | 78681 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 399 | 8 | 0 | 5 | 4.2 | CO/N=C(\CCN1CCN(c2ccccc2OC(C)C)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
44300865 | 200310 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 317 | 4 | 1 | 2 | 4.0 | c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL60815 | 200310 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 317 | 4 | 1 | 2 | 4.0 | c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
16094681 | 82934 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(F)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL219261 | 82934 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(F)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
44418747 | 82965 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 3.9 | Cc1cccc(Cl)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
CHEMBL219394 | 82965 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 343 | 4 | 1 | 3 | 3.9 | Cc1cccc(Cl)c1NC(=O)CN1CCC(c2ccccn2)CC1 | 10.1021/jm060662k | ||
5311189 | 203133 | 4 | None | -2 | 4 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL7549 | 203133 | 4 | None | -2 | 4 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | 10.1016/s0960-894x(02)00390-6 | ||
11336814 | 79691 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
CHEMBL213164 | 79691 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
71456253 | 78682 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 399 | 8 | 0 | 5 | 4.2 | CO/N=C(/CCN1CCN(c2ccccc2OC(C)C)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL2113244 | 78682 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 399 | 8 | 0 | 5 | 4.2 | CO/N=C(/CCN1CCN(c2ccccc2OC(C)C)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
11739823 | 79361 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(\CCN1CCCC(c2ccccn2)C1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL211831 | 79361 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(\CCN1CCCC(c2ccccn2)C1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
11151920 | 79624 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
CHEMBL212903 | 79624 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
109030343 | 170293 | 1 | None | 1 | 3 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4454068 | 170293 | 1 | None | 1 | 3 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
11849735 | 137704 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 339 | 7 | 0 | 6 | 2.4 | CCO/N=C(\CCN1CCN(c2ncccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL377023 | 137704 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 339 | 7 | 0 | 6 | 2.4 | CCO/N=C(\CCN1CCN(c2ncccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
10066168 | 161300 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 345 | 4 | 1 | 3 | 2.8 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(Cl)c1 | 10.1021/jm060662k | ||
CHEMBL414706 | 161300 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 345 | 4 | 1 | 3 | 2.8 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(Cl)c1 | 10.1021/jm060662k | ||
10428816 | 82935 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 363 | 4 | 1 | 3 | 2.7 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060662k | ||
CHEMBL219263 | 82935 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 363 | 4 | 1 | 3 | 2.7 | O=C(NCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060662k | ||
11256583 | 168221 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 349 | 6 | 0 | 6 | 2.5 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(C#N)c1 | 10.1021/jm060279f | ||
CHEMBL437493 | 168221 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 349 | 6 | 0 | 6 | 2.5 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(C#N)c1 | 10.1021/jm060279f | ||
10024158 | 82928 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 403 | 4 | 1 | 3 | 3.2 | Cc1cc(Br)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL219211 | 82928 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 403 | 4 | 1 | 3 | 3.2 | Cc1cc(Br)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
10404821 | 168115 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 337 | 5 | 1 | 3 | 2.5 | C=Cc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL436527 | 168115 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 337 | 5 | 1 | 3 | 2.5 | C=Cc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
10383571 | 82845 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 355 | 5 | 1 | 4 | 2.2 | COc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1C | 10.1021/jm060662k | ||
CHEMBL218757 | 82845 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 355 | 5 | 1 | 4 | 2.2 | COc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1C | 10.1021/jm060662k | ||
11849687 | 79596 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 311 | 5 | 1 | 6 | 1.9 | O/N=C(/CCN1CCN(c2ncccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL212804 | 79596 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 311 | 5 | 1 | 6 | 1.9 | O/N=C(/CCN1CCN(c2ncccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11724450 | 123330 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184158 | 123330 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL362542 | 123330 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
44400626 | 70059 | 0 | None | -2 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL194555 | 70059 | 0 | None | -2 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
16094670 | 83042 | 5 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 324 | 4 | 2 | 3 | 3.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(O)cc3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219966 | 83042 | 5 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 324 | 4 | 2 | 3 | 3.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(O)cc3)CC2)c1 | 10.1021/jm060662k | ||
11772112 | 168251 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1C | 10.1021/jm060279f | ||
CHEMBL437687 | 168251 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1C | 10.1021/jm060279f | ||
11849779 | 79485 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(C)cc(C)c1 | 10.1021/jm060279f | ||
CHEMBL212393 | 79485 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(C)cc(C)c1 | 10.1021/jm060279f | ||
16094707 | 96278 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.2 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm060662k | ||
CHEMBL264286 | 96278 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 3.2 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm060662k | ||
16094667 | 81430 | 5 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 333 | 4 | 1 | 3 | 3.7 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3C#N)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL216450 | 81430 | 5 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 333 | 4 | 1 | 3 | 3.7 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3C#N)CC2)c1 | 10.1021/jm060662k | ||
16094700 | 169156 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 324 | 4 | 2 | 3 | 3.5 | Cc1cccc(NC(=O)CN2CCC(c3cccc(O)c3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL443838 | 169156 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 324 | 4 | 2 | 3 | 3.5 | Cc1cccc(NC(=O)CN2CCC(c3cccc(O)c3)CC2)c1 | 10.1021/jm060662k | ||
3645619 | 2985 | 13 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm060279f | ||
975 | 2985 | 13 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm060279f | ||
CHEMBL45244 | 2985 | 13 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm060279f | ||
3645619 | 2985 | 13 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm060662k | ||
975 | 2985 | 13 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm060662k | ||
CHEMBL45244 | 2985 | 13 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm060662k | ||
10737474 | 100883 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1021/jm970021c | ||
CHEMBL296953 | 100883 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1021/jm970021c | ||
10473658 | 186610 | 3 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1021/jm970021c | ||
CHEMBL49231 | 186610 | 3 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1021/jm970021c | ||
168285560 | 192316 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196873 | 192316 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222201 | 192316 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
155515982 | 169443 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4442460 | 169443 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
11849682 | 79909 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 2.8 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1F | 10.1021/jm060279f | ||
CHEMBL214190 | 79909 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 2.8 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1F | 10.1021/jm060279f | ||
11849736 | 137887 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 344 | 7 | 0 | 6 | 3.1 | CCO/N=C(\CCN1CCN(c2nccs2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL377388 | 137887 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 344 | 7 | 0 | 6 | 3.1 | CCO/N=C(\CCN1CCN(c2nccs2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
11774041 | 79610 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 402 | 6 | 0 | 5 | 3.4 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Br)cc1 | 10.1021/jm060279f | ||
CHEMBL212872 | 79610 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 402 | 6 | 0 | 5 | 3.4 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Br)cc1 | 10.1021/jm060279f | ||
11394708 | 79672 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 373 | 6 | 0 | 4 | 3.6 | CO/N=C(\CCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL213097 | 79672 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 373 | 6 | 0 | 4 | 3.6 | CO/N=C(\CCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
10359645 | 141004 | 4 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 336 | 4 | 1 | 4 | 1.8 | N#Cc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL384690 | 141004 | 4 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 336 | 4 | 1 | 4 | 1.8 | N#Cc1cccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
10385883 | 81159 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)cc1C(F)(F)F | 10.1021/jm060662k | ||
CHEMBL216215 | 81159 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)cc1C(F)(F)F | 10.1021/jm060662k | ||
10314506 | 168111 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccc(F)cc1 | 10.1021/jm060662k | ||
CHEMBL436491 | 168111 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 329 | 4 | 1 | 3 | 2.3 | O=C(CN1CCC(c2cccc[n+]2[O-])CC1)Nc1ccc(F)cc1 | 10.1021/jm060662k | ||
11772767 | 79592 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL212784 | 79592 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
16094676 | 230 | 17 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
8439 | 230 | 17 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
CHEMBL219182 | 230 | 17 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
16094699 | 81733 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.0 | Cc1cccc(C(=O)NCN2CCC(c3ccccn3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL216794 | 81733 | 4 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.0 | Cc1cccc(C(=O)NCN2CCC(c3ccccn3)CC2)c1 | 10.1021/jm060662k | ||
9859861 | 167517 | 1 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 218 | 0 | 1 | 2 | 3.2 | Cc1sc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL432579 | 167517 | 1 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 218 | 0 | 1 | 2 | 3.2 | Cc1sc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
10314824 | 35153 | 1 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL143761 | 35153 | 1 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
11849818 | 77564 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 342 | 6 | 1 | 5 | 3.0 | O/N=C(\CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL209447 | 77564 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 342 | 6 | 1 | 5 | 3.0 | O/N=C(\CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
11983282 | 138414 | 0 | None | -2 | 3 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 315 | 4 | 0 | 3 | 4.2 | C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL378455 | 138414 | 0 | None | -2 | 3 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 315 | 4 | 0 | 3 | 4.2 | C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
16094665 | 83056 | 5 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 315 | 4 | 1 | 4 | 3.0 | Cc1cccc(C(=O)NCN2CCC(c3nccs3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL220083 | 83056 | 5 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 315 | 4 | 1 | 4 | 3.0 | Cc1cccc(C(=O)NCN2CCC(c3nccs3)CC2)c1 | 10.1021/jm060662k | ||
10449865 | 82857 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.5 | Cc1cc(C)cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL218798 | 82857 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 2.5 | Cc1cc(C)cc(C(=O)NCN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
11416883 | 80718 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(C)c(C)c1 | 10.1021/jm060279f | ||
CHEMBL215678 | 80718 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(C)c(C)c1 | 10.1021/jm060279f | ||
16094676 | 230 | 17 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
8439 | 230 | 17 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
CHEMBL219182 | 230 | 17 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
15981509 | 141426 | 1 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2 | 10.1021/jm0604979 | ||
CHEMBL387250 | 141426 | 1 | None | -3 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2 | 10.1021/jm0604979 | ||
11222637 | 79373 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 6 | 0 | 5 | 3.4 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL211902 | 79373 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 6 | 0 | 5 | 3.4 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060279f | ||
16094680 | 82962 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 5 | 1 | 3 | 2.7 | CCc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219389 | 82962 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 339 | 5 | 1 | 3 | 2.7 | CCc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
44393797 | 66028 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 3.4 | Cc1cc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)ccc1Br | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL185149 | 66028 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 3.4 | Cc1cc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)ccc1Br | 10.1016/j.bmcl.2004.07.068 | ||
11849266 | 80657 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.6 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(C)c1 | 10.1021/jm060279f | ||
CHEMBL215450 | 80657 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.6 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(C)c1 | 10.1021/jm060279f | ||
11849781 | 79911 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.7 | CO/N=C(/CCN1CCN(c2ccccn2)CC1C)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL214197 | 79911 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 372 | 6 | 0 | 5 | 3.7 | CO/N=C(/CCN1CCN(c2ccccn2)CC1C)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
9995904 | 31004 | 2 | None | - | 0 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL140099 | 31004 | 2 | None | - | 0 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
71458071 | 79090 | 0 | None | - | 0 | Human | 8.1 | pED50 | = | 8.1 | Functional | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL2113718 | 79090 | 0 | None | - | 0 | Human | 8.1 | pED50 | = | 8.1 | Functional | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1 | 10.1016/s0960-894x(02)00316-5 | ||
9926143 | 113027 | 1 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 294 | 6 | 2 | 4 | 3.0 | O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL332154 | 113027 | 1 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 294 | 6 | 2 | 4 | 3.0 | O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
168285556 | 192315 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196870 | 192315 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222200 | 192315 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
168277064 | 192236 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5178868 | 192236 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221670 | 192236 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
168268756 | 192162 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5171439 | 192162 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221187 | 192162 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
168268756 | 192162 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5171439 | 192162 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221187 | 192162 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
45361874 | 169454 | 2 | None | 58 | 3 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4442548 | 169454 | 2 | None | 58 | 3 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
3303 | 2213 | 41 | None | 1 | 5 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
5311200 | 2213 | 41 | None | 1 | 5 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 5 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
10021193 | 66031 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 356 | 5 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL185156 | 66031 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 356 | 5 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
3303 | 2213 | 41 | None | 1 | 5 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
5311200 | 2213 | 41 | None | 1 | 5 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 5 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
109030343 | 170293 | 1 | None | 1 | 3 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4454068 | 170293 | 1 | None | 1 | 3 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
135398737 | 944 | 89 | None | -44 | 36 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
38 | 944 | 89 | None | -44 | 36 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
722 | 944 | 89 | None | -44 | 36 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
CHEMBL42 | 944 | 89 | None | -44 | 36 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
DB00363 | 944 | 89 | None | -44 | 36 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
155513053 | 169131 | 0 | None | 23 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4437912 | 169131 | 0 | None | 23 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
3303 | 2213 | 41 | None | 1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
5311200 | 2213 | 41 | None | 1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
16094666 | 81315 | 2 | None | 251 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL216393 | 81315 | 2 | None | 251 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
109030515 | 175412 | 1 | None | 14 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4588808 | 175412 | 1 | None | 14 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168285556 | 192315 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196870 | 192315 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222200 | 192315 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
155536720 | 171621 | 0 | None | 37 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473652 | 171621 | 0 | None | 37 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168277064 | 192236 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5178868 | 192236 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221670 | 192236 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
155536815 | 171641 | 0 | None | 13 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473792 | 171641 | 0 | None | 13 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1021/acs.jmedchem.9b00231 | ||
168268756 | 192162 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5171439 | 192162 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221187 | 192162 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
168285556 | 192315 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196870 | 192315 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222200 | 192315 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
168277064 | 192236 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5178868 | 192236 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221670 | 192236 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
155568411 | 175506 | 0 | None | 2 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 331 | 4 | 1 | 5 | 1.9 | O=C(CN1CCN(c2ccc(Cl)cn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4591118 | 175506 | 0 | None | 2 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 331 | 4 | 1 | 5 | 1.9 | O=C(CN1CCN(c2ccc(Cl)cn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
155562395 | 175375 | 0 | None | 169 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4587925 | 175375 | 0 | None | 169 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
6466372 | 169495 | 12 | None | 58 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443054 | 169495 | 12 | None | 58 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
155563301 | 174678 | 0 | None | 10 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4572245 | 174678 | 0 | None | 10 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
9907332 | 16219 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 368 | 3 | 0 | 4 | 4.1 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1Cl | 10.1021/jm990266k | ||
CHEMBL123031 | 16219 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 368 | 3 | 0 | 4 | 4.1 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1Cl | 10.1021/jm990266k | ||
155530763 | 171003 | 0 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4464861 | 171003 | 0 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168285560 | 192316 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196873 | 192316 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222201 | 192316 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
10425450 | 199 | 23 | None | 125 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
3301 | 199 | 23 | None | 125 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL375596 | 199 | 23 | None | 125 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
155511803 | 169038 | 0 | None | 1 | 2 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 342 | 4 | 1 | 2 | 4.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4436479 | 169038 | 0 | None | 1 | 2 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 342 | 4 | 1 | 2 | 4.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
155516494 | 169554 | 0 | None | 6 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 358 | 5 | 1 | 4 | 3.1 | CCc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443848 | 169554 | 0 | None | 6 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 358 | 5 | 1 | 4 | 3.1 | CCc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
4797946 | 169856 | 8 | None | 81 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4448320 | 169856 | 8 | None | 81 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
155568867 | 175580 | 0 | None | -3 | 3 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4592753 | 175580 | 0 | None | -3 | 3 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
9948546 | 16148 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 308 | 6 | 2 | 4 | 3.3 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1 | 10.1021/jm990266k | ||
CHEMBL122754 | 16148 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 308 | 6 | 2 | 4 | 3.3 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1 | 10.1021/jm990266k | ||
24815434 | 198014 | 0 | None | - | 2 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 4.0 | Cn1c(CN2CCC(c3ccccc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL593196 | 198014 | 0 | None | - | 2 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 4.0 | Cn1c(CN2CCC(c3ccccc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
46225337 | 198294 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 375 | 3 | 0 | 5 | 3.3 | Cn1c(CN2CCN(c3ccc(C(F)(F)F)cn3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL595151 | 198294 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 375 | 3 | 0 | 5 | 3.3 | Cn1c(CN2CCN(c3ccc(C(F)(F)F)cn3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
24815976 | 198077 | 0 | None | - | 2 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 373 | 3 | 0 | 3 | 5.0 | Cn1c(CN2CCC(c3ccc(C(F)(F)F)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL593745 | 198077 | 0 | None | - | 2 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 373 | 3 | 0 | 3 | 5.0 | Cn1c(CN2CCC(c3ccc(C(F)(F)F)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
798232 | 198451 | 9 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 340 | 3 | 0 | 4 | 3.5 | Cn1c(CN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL596271 | 198451 | 9 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 340 | 3 | 0 | 4 | 3.5 | Cn1c(CN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
10615684 | 17857 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL1202208 | 17857 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL126493 | 17857 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
44517726 | 194348 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 341 | 4 | 0 | 2 | 3.6 | O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1 | 10.1016/j.bmcl.2009.06.043 | ||
CHEMBL560177 | 194348 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 341 | 4 | 0 | 2 | 3.6 | O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1 | 10.1016/j.bmcl.2009.06.043 | ||
46225583 | 198490 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 362 | 3 | 0 | 5 | 4.6 | Cn1c(CN2CCC(c3nsc4ccccc34)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL596527 | 198490 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 362 | 3 | 0 | 5 | 4.6 | Cn1c(CN2CCC(c3nsc4ccccc34)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
1353 | 1880 | 85 | None | -7 | 27 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
3559 | 1880 | 85 | None | -7 | 27 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
86 | 1880 | 85 | None | -7 | 27 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
CHEMBL54 | 1880 | 85 | None | -7 | 27 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
DB00502 | 1880 | 85 | None | -7 | 27 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
9820304 | 101599 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL1204116 | 101599 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL302075 | 101599 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
46225334 | 198363 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 358 | 3 | 0 | 4 | 3.7 | Cn1c(CN2CCN(c3ccc(Cl)cc3F)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL595607 | 198363 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 358 | 3 | 0 | 4 | 3.7 | Cn1c(CN2CCN(c3ccc(Cl)cc3F)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
24815883 | 199777 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 373 | 3 | 0 | 3 | 5.0 | Cn1c(CN2CCC(c3cccc(C(F)(F)F)c3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL604993 | 199777 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 373 | 3 | 0 | 3 | 5.0 | Cn1c(CN2CCC(c3cccc(C(F)(F)F)c3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
46225581 | 200302 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 339 | 3 | 0 | 3 | 4.6 | Cn1c(CN2CCC(c3cccc(Cl)c3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL608103 | 200302 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 339 | 3 | 0 | 3 | 4.6 | Cn1c(CN2CCC(c3cccc(Cl)c3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
46190878 | 1842 | 3 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 2.3 | Clc1cnc(nc1)N1CCN(CC1)Cc1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.11.032 | ||
6253 | 1842 | 3 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 2.3 | Clc1cnc(nc1)N1CCN(CC1)Cc1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL595759 | 1842 | 3 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 2.3 | Clc1cnc(nc1)N1CCN(CC1)Cc1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.11.032 | ||
46225584 | 197993 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 408 | 3 | 0 | 4 | 5.0 | Cn1c(CN2CCC(c3ncc(C(F)(F)F)cc3Cl)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL593056 | 197993 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 408 | 3 | 0 | 4 | 5.0 | Cn1c(CN2CCC(c3ncc(C(F)(F)F)cc3Cl)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
10157556 | 119730 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 395 | 3 | 0 | 3 | 3.4 | O=C1C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2cccc3c2N1CC3 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL352207 | 119730 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 395 | 3 | 0 | 3 | 3.4 | O=C1C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2cccc3c2N1CC3 | 10.1016/s0960-894x(02)01056-9 | ||
3691783 | 4696 | 1 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 318 | 4 | 1 | 3 | 3.4 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)c[nH]2)cc1 | 10.1016/j.bmc.2010.01.040 | ||
CHEMBL103871 | 4696 | 1 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 318 | 4 | 1 | 3 | 3.4 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)c[nH]2)cc1 | 10.1016/j.bmc.2010.01.040 | ||
46225335 | 198364 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 374 | 3 | 0 | 4 | 3.9 | Cn1c(CN2CCN(c3ccc(C(F)(F)F)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL595608 | 198364 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 374 | 3 | 0 | 4 | 3.9 | Cn1c(CN2CCN(c3ccc(C(F)(F)F)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
24849462 | 198076 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 339 | 3 | 0 | 3 | 4.6 | Cn1c(CN2CCC(c3ccc(Cl)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL593744 | 198076 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 339 | 3 | 0 | 3 | 4.6 | Cn1c(CN2CCC(c3ccc(Cl)cc3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
46190877 | 1841 | 3 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 409 | 3 | 0 | 5 | 4.0 | Clc1cc(cnc1N1CCN(CC1)Cc1nc2c(n1C)cccc2)C(F)(F)F | 10.1016/j.bmcl.2009.11.032 | ||
6252 | 1841 | 3 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 409 | 3 | 0 | 5 | 4.0 | Clc1cc(cnc1N1CCN(CC1)Cc1nc2c(n1C)cccc2)C(F)(F)F | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL605836 | 1841 | 3 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 409 | 3 | 0 | 5 | 4.0 | Clc1cc(cnc1N1CCN(CC1)Cc1nc2c(n1C)cccc2)C(F)(F)F | 10.1016/j.bmcl.2009.11.032 | ||
46225320 | 199498 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 374 | 3 | 0 | 4 | 3.9 | Cn1c(CN2CCN(c3ccccc3C(F)(F)F)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL603443 | 199498 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 374 | 3 | 0 | 4 | 3.9 | Cn1c(CN2CCN(c3ccccc3C(F)(F)F)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
9799123 | 5543 | 0 | None | 61 | 2 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107742 | 5543 | 0 | None | 61 | 2 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
46225582 | 199930 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 362 | 3 | 0 | 5 | 4.6 | Cn1c(CN2CCC(c3nc4ccccc4s3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL605831 | 199930 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 362 | 3 | 0 | 5 | 4.6 | Cn1c(CN2CCC(c3nc4ccccc4s3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
46225336 | 198365 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 363 | 3 | 0 | 6 | 3.5 | Cn1c(CN2CCN(c3nc4ccccc4s3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
CHEMBL595609 | 198365 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 363 | 3 | 0 | 6 | 3.5 | Cn1c(CN2CCN(c3nc4ccccc4s3)CC2)nc2ccccc21 | 10.1016/j.bmcl.2009.11.032 | ||
9952003 | 5288 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106916 | 5288 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
681 | 1437 | 65 | None | -1 | 12 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
940 | 1437 | 65 | None | -1 | 12 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
947 | 1437 | 65 | None | -1 | 12 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
CHEMBL59 | 1437 | 65 | None | -1 | 12 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
DB00988 | 1437 | 65 | None | -1 | 12 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
228 | 441 | 26 | None | 1 | 8 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
33 | 441 | 26 | None | 1 | 8 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
6005 | 441 | 26 | None | 1 | 8 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
CHEMBL53 | 441 | 26 | None | 1 | 8 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
DB00714 | 441 | 26 | None | 1 | 8 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
30699 | 215969 | 0 | None | -1 | 14 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 423 | 7 | 2 | 8 | 0.5 | CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O | None | ||
4223 | 3929 | 88 | None | -588 | 15 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
6918314 | 3929 | 88 | None | -588 | 15 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
7427 | 3929 | 88 | None | -588 | 15 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
CHEMBL439849 | 3929 | 88 | None | -588 | 15 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
DB06684 | 3929 | 88 | None | -588 | 15 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
10263487 | 3020 | 0 | None | -19 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 235 | 3 | 1 | 4 | 1.8 | CCCN1C[C@H](OC[C@@H]1C)c1ccc(nc1)N | 22470105 | ||
7683 | 3020 | 0 | None | -19 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 235 | 3 | 1 | 4 | 1.8 | CCCN1C[C@H](OC[C@@H]1C)c1ccc(nc1)N | 22470105 |
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
14925759 | 157494 | 6 | None | 18 | 13 | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4085780 | 157494 | 6 | None | 18 | 13 | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
9945233 | 203383 | 1 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
CHEMBL77563 | 203383 | 1 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
228 | 441 | 26 | None | - | 24 | Rat | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
33 | 441 | 26 | None | - | 24 | Rat | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
6005 | 441 | 26 | None | - | 24 | Rat | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
CHEMBL53 | 441 | 26 | None | - | 24 | Rat | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
DB00714 | 441 | 26 | None | - | 24 | Rat | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
9857248 | 203394 | 6 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
CHEMBL77708 | 203394 | 6 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
10268039 | 17832 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 321 | 4 | 1 | 3 | 4.0 | COc1ccccc1C1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL126361 | 17832 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 321 | 4 | 1 | 3 | 4.0 | COc1ccccc1C1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
44315403 | 203760 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 327 | 3 | 1 | 4 | 2.9 | Clc1ccccc1N1CCN(Cc2nc3ccc[nH]c-3n2)CC1 | 10.1021/jm0305669 | ||
CHEMBL80469 | 203760 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 327 | 3 | 1 | 4 | 2.9 | Clc1ccccc1N1CCN(Cc2nc3ccc[nH]c-3n2)CC1 | 10.1021/jm0305669 | ||
164612037 | 184795 | 0 | None | -1 | 20 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL4860528 | 184795 | 0 | None | -1 | 20 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | ||
11392147 | 17904 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 290 | 3 | 1 | 3 | 3.2 | C1=C(c2ccccn2)CCN(Cc2nc3ccccc3[nH]2)C1 | 10.1021/jm030505a | ||
CHEMBL126754 | 17904 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 290 | 3 | 1 | 3 | 3.2 | C1=C(c2ccccn2)CCN(Cc2nc3ccccc3[nH]2)C1 | 10.1021/jm030505a | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
5025739 | 168630 | 40 | None | 30 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm0305669 | ||
CHEMBL440687 | 168630 | 40 | None | 30 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm0305669 | ||
4826074 | 103627 | 6 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL309372 | 103627 | 6 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
5025739 | 168630 | 40 | None | 30 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
CHEMBL440687 | 168630 | 40 | None | 30 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
9836662 | 97701 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 318 | 3 | 1 | 5 | 2.2 | N#Cc1cccnc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL273772 | 97701 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 318 | 3 | 1 | 5 | 2.2 | N#Cc1cccnc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
45361874 | 169454 | 2 | None | 48 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4442548 | 169454 | 2 | None | 48 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
11474209 | 116871 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 371 | 4 | 1 | 6 | 1.7 | CS(=O)(=O)c1cccnc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL339791 | 116871 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 371 | 4 | 1 | 6 | 1.7 | CS(=O)(=O)c1cccnc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
9835713 | 18300 | 1 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 3.3 | c1ccc(C2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
CHEMBL127226 | 18300 | 1 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 3.3 | c1ccc(C2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
5025739 | 168630 | 40 | None | - | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
CHEMBL440687 | 168630 | 40 | None | - | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
9858141 | 117126 | 1 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 317 | 3 | 1 | 4 | 2.8 | N#Cc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL340099 | 117126 | 1 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 317 | 3 | 1 | 4 | 2.8 | N#Cc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
9901273 | 17861 | 3 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL126510 | 17861 | 3 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0305669 | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0305669 | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0305669 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
681 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
940 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
947 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
CHEMBL59 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
DB00988 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
681 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
940 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
947 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
CHEMBL59 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
DB00988 | 1437 | 65 | None | -7 | 38 | Rat | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm030505a | ||
973 | 1154 | 33 | None | 9 | 6 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
9796720 | 1154 | 33 | None | 9 | 6 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
CHEMBL77395 | 1154 | 33 | None | 9 | 6 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0305669 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0305669 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0305669 | ||
168294767 | 192417 | 0 | None | -1 | 20 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5207281 | 192417 | 0 | None | -1 | 20 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5222802 | 192417 | 0 | None | -1 | 20 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
9838927 | 18632 | 11 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 289 | 3 | 1 | 2 | 3.9 | C1=C(c2ccccc2)CCN(Cc2nc3ccccc3[nH]2)C1 | 10.1021/jm030505a | ||
CHEMBL127930 | 18632 | 11 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 289 | 3 | 1 | 2 | 3.9 | C1=C(c2ccccc2)CCN(Cc2nc3ccccc3[nH]2)C1 | 10.1021/jm030505a | ||
11255258 | 18645 | 4 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 307 | 4 | 1 | 4 | 2.3 | c1ccc(N2CCN(CCc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
CHEMBL128040 | 18645 | 4 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 307 | 4 | 1 | 4 | 2.3 | c1ccc(N2CCN(CCc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
5025739 | 168630 | 40 | None | - | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
CHEMBL440687 | 168630 | 40 | None | - | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
9966489 | 17892 | 1 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 2.4 | Fc1cccnc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL126687 | 17892 | 1 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 2.4 | Fc1cccnc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
16094666 | 81315 | 2 | None | 52 | 3 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL216393 | 81315 | 2 | None | 52 | 3 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
9945714 | 18532 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 3.3 | CCOc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL127752 | 18532 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 3.3 | CCOc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
155515982 | 169443 | 0 | None | 6 | 17 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4442460 | 169443 | 0 | None | 6 | 17 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
155568867 | 175580 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4592753 | 175580 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
6466372 | 169495 | 12 | None | 93 | 3 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443054 | 169495 | 12 | None | 93 | 3 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
9945753 | 16689 | 5 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 337 | 4 | 1 | 5 | 2.8 | O=[N+]([O-])c1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL124927 | 16689 | 5 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 337 | 4 | 1 | 5 | 2.8 | O=[N+]([O-])c1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
9857248 | 203394 | 6 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm030505a | ||
CHEMBL77708 | 203394 | 6 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm030505a | ||
973 | 1154 | 33 | None | -9 | 6 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm0305669 | ||
9796720 | 1154 | 33 | None | -9 | 6 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm0305669 | ||
CHEMBL77395 | 1154 | 33 | None | -9 | 6 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm0305669 | ||
973 | 1154 | 33 | None | -9 | 6 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
9796720 | 1154 | 33 | None | -9 | 6 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
CHEMBL77395 | 1154 | 33 | None | -9 | 6 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
155559617 | 174312 | 0 | None | 9 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4563944 | 174312 | 0 | None | 9 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
137646281 | 157264 | 0 | None | -1659 | 17 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
CHEMBL4083252 | 157264 | 0 | None | -1659 | 17 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
973 | 1154 | 33 | None | 9 | 6 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
9796720 | 1154 | 33 | None | 9 | 6 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
CHEMBL77395 | 1154 | 33 | None | 9 | 6 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
9879627 | 16875 | 1 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 307 | 3 | 1 | 4 | 2.6 | Cc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)n1 | 10.1021/jm030505a | ||
CHEMBL125464 | 16875 | 1 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 307 | 3 | 1 | 4 | 2.6 | Cc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)n1 | 10.1021/jm030505a | ||
4797946 | 169856 | 8 | None | 165 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4448320 | 169856 | 8 | None | 165 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
72901200 | 119272 | 21 | None | 154 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
CHEMBL3480577 | 119272 | 21 | None | 154 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
228 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
33 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
6005 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
CHEMBL53 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
DB00714 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
10225902 | 17894 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 449 | 3 | 1 | 4 | 3.8 | Brc1cc(Br)c2[nH]c(CN3CCN(c4ccccn4)CC3)nc2c1 | 10.1021/jm030505a | ||
CHEMBL126698 | 17894 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 449 | 3 | 1 | 4 | 3.8 | Brc1cc(Br)c2[nH]c(CN3CCN(c4ccccn4)CC3)nc2c1 | 10.1021/jm030505a | ||
10014924 | 106787 | 0 | None | -16 | 5 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm049269+ | ||
CHEMBL316983 | 106787 | 0 | None | -16 | 5 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm049269+ | ||
9922161 | 17874 | 5 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 294 | 3 | 1 | 5 | 1.7 | c1cnc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
CHEMBL126595 | 17874 | 5 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 294 | 3 | 1 | 5 | 1.7 | c1cnc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm030505a | ||
10425450 | 199 | 23 | None | -1 | 4 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
3301 | 199 | 23 | None | -1 | 4 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL375596 | 199 | 23 | None | -1 | 4 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
228 | 441 | 26 | None | - | 24 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
33 | 441 | 26 | None | - | 24 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
6005 | 441 | 26 | None | - | 24 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
CHEMBL53 | 441 | 26 | None | - | 24 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
DB00714 | 441 | 26 | None | - | 24 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm030505a | ||
4826074 | 103627 | 6 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
CHEMBL309372 | 103627 | 6 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
44381216 | 119826 | 0 | None | 8511 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL352925 | 119826 | 0 | None | 8511 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
155552185 | 173489 | 0 | None | 2 | 16 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4544086 | 173489 | 0 | None | 2 | 16 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
9815072 | 17866 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 307 | 3 | 1 | 4 | 2.7 | C[C@H]1CN(c2ccccn2)CCN1Cc1nc2ccccc2[nH]1 | 10.1021/jm030505a | ||
CHEMBL126530 | 17866 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 307 | 3 | 1 | 4 | 2.7 | C[C@H]1CN(c2ccccn2)CCN1Cc1nc2ccccc2[nH]1 | 10.1021/jm030505a | ||
9836209 | 17865 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 307 | 3 | 1 | 4 | 2.7 | C[C@@H]1CN(c2ccccn2)CCN1Cc1nc2ccccc2[nH]1 | 10.1021/jm030505a | ||
CHEMBL126529 | 17865 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 307 | 3 | 1 | 4 | 2.7 | C[C@@H]1CN(c2ccccn2)CCN1Cc1nc2ccccc2[nH]1 | 10.1021/jm030505a | ||
168290235 | 192366 | 0 | None | -5 | 20 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5201074 | 192366 | 0 | None | -5 | 20 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5222491 | 192366 | 0 | None | -5 | 20 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
168295528 | 192429 | 0 | None | -1 | 20 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5206565 | 192429 | 0 | None | -1 | 20 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5222872 | 192429 | 0 | None | -1 | 20 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
9945233 | 203383 | 1 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL77563 | 203383 | 1 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
9857887 | 18343 | 2 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 2.4 | Fc1ccc2[nH]c(CN3CCN(c4ccccn4)CC3)nc2c1 | 10.1021/jm030505a | ||
CHEMBL127460 | 18343 | 2 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 2.4 | Fc1ccc2[nH]c(CN3CCN(c4ccccn4)CC3)nc2c1 | 10.1021/jm030505a | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acs.jmedchem.9b01085 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/acs.jmedchem.9b01085 | ||
9881000 | 116439 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 3.6 | CSc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
CHEMBL338547 | 116439 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 3.6 | CSc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm030505a | ||
1588 | 2294 | 24 | None | -23 | 43 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/acs.jmedchem.9b00412 | ||
28864 | 2294 | 24 | None | -23 | 43 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/acs.jmedchem.9b00412 | ||
43 | 2294 | 24 | None | -23 | 43 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/acs.jmedchem.9b00412 | ||
CHEMBL157138 | 2294 | 24 | None | -23 | 43 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/acs.jmedchem.9b00412 | ||
DB00589 | 2294 | 24 | None | -23 | 43 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/acs.jmedchem.9b00412 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(03)00004-0 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(03)00004-0 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acs.jmedchem.8b00265 | ||
155536720 | 171621 | 0 | None | 77 | 3 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473652 | 171621 | 0 | None | 77 | 3 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
3626837 | 205584 | 8 | None | 125 | 4 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL93403 | 205584 | 8 | None | 125 | 4 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm981041x | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
14925759 | 157494 | 6 | None | 18 | 13 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4085780 | 157494 | 6 | None | 18 | 13 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00361-8 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00361-8 | ||
10783358 | 39429 | 4 | None | 42 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 340 | 6 | 1 | 5 | 1.6 | COc1cccc(C(=O)NCCN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL147483 | 39429 | 4 | None | 42 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 340 | 6 | 1 | 5 | 1.6 | COc1cccc(C(=O)NCCN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm981041x | ||
10406796 | 99540 | 9 | None | -19 | 5 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL286725 | 99540 | 9 | None | -19 | 5 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
11738728 | 18313 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(C)c(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm030505a | ||
CHEMBL127290 | 18313 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(C)c(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm030505a | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm981041x | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm981041x | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm981041x | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm981041x | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm981041x | ||
9104271 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1021/jm058225d | ||
CHEMBL69584 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1021/jm058225d | ||
10497674 | 17823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202219 | 17823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL126322 | 17823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
10570563 | 17846 | 0 | None | 15 | 2 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/jm990562x | ||
CHEMBL1202212 | 17846 | 0 | None | 15 | 2 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/jm990562x | ||
CHEMBL126429 | 17846 | 0 | None | 15 | 2 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/jm990562x | ||
127030612 | 138800 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.7 | Clc1ccc(CN2CCO[C@H](COc3cccc(Cl)n3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792725 | 138800 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.7 | Clc1ccc(CN2CCO[C@H](COc3cccc(Cl)n3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127029391 | 138818 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1cc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792907 | 138818 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1cc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
118714552 | 114029 | 0 | None | 97 | 2 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 3.2 | Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335555 | 114029 | 0 | None | 97 | 2 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 3.2 | Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
135512187 | 34376 | 6 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 336 | 3 | 2 | 5 | 2.0 | O=c1[nH]c(CN2CCN(c3ccccc3O)CC2)nc2ccccc12 | nan | ||
CHEMBL1429613 | 34376 | 6 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 336 | 3 | 2 | 5 | 2.0 | O=c1[nH]c(CN2CCN(c3ccccc3O)CC2)nc2ccccc12 | nan | ||
168276065 | 189626 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 4.0 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(C#N)cc3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5174753 | 189626 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 4.0 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(C#N)cc3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
127030606 | 138832 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793033 | 138832 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
155516494 | 169554 | 0 | None | 269 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 358 | 5 | 1 | 4 | 3.1 | CCc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443848 | 169554 | 0 | None | 269 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 358 | 5 | 1 | 4 | 3.1 | CCc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168296347 | 191864 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 344 | 6 | 0 | 4 | 3.7 | COc1ccc(CN2CCC[C@H](OCc3cccc(C)n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5208643 | 191864 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 344 | 6 | 0 | 4 | 3.7 | COc1ccc(CN2CCC[C@H](OCc3cccc(C)n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
109030343 | 170293 | 1 | None | 15 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4454068 | 170293 | 1 | None | 15 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
127028185 | 138806 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 375 | 5 | 1 | 4 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(Cl)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792751 | 138806 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 375 | 5 | 1 | 4 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(Cl)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
16104 | 161368 | 15 | None | -1 | 5 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm991005d | ||
CHEMBL415300 | 161368 | 15 | None | -1 | 5 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm991005d | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
10645208 | 35960 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 409 | 7 | 0 | 6 | 4.2 | COc1cccc(-c2csc(CCN3CCN(c4ccccc4OC)CC3)n2)c1 | 10.1021/jm981041x | ||
CHEMBL144494 | 35960 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 409 | 7 | 0 | 6 | 4.2 | COc1cccc(-c2csc(CCN3CCN(c4ccccc4OC)CC3)n2)c1 | 10.1021/jm981041x | ||
CHEMBL2373205 | 35960 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 409 | 7 | 0 | 6 | 4.2 | COc1cccc(-c2csc(CCN3CCN(c4ccccc4OC)CC3)n2)c1 | 10.1021/jm981041x | ||
9868793 | 96529 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 458 | 8 | 1 | 8 | 2.8 | COc1nsnc1N1CCN(C[C@@H](Cc2cccnc2)NC(=O)C2(C)CCCCC2)CC1 | 10.1016/s0960-894x(01)00151-2 | ||
CHEMBL266393 | 96529 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 458 | 8 | 1 | 8 | 2.8 | COc1nsnc1N1CCN(C[C@@H](Cc2cccnc2)NC(=O)C2(C)CCCCC2)CC1 | 10.1016/s0960-894x(01)00151-2 | ||
127053218 | 138948 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 334 | 5 | 0 | 4 | 3.5 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794336 | 138948 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 334 | 5 | 0 | 4 | 3.5 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
1016 | 3690 | 75 | None | -28 | 35 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2561 | 3690 | 75 | None | -28 | 35 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2733526 | 3690 | 75 | None | -28 | 35 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
5384 | 3690 | 75 | None | -28 | 35 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
CHEMBL83 | 3690 | 75 | None | -28 | 35 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
DB00675 | 3690 | 75 | None | -28 | 35 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
70788951 | 26948 | 1 | None | -1 | 5 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | ||||
CHEMBL1366 | 26948 | 1 | None | -1 | 5 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | ||||
72737750 | 114025 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 299 | 5 | 0 | 2 | 3.7 | Fc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335543 | 114025 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 299 | 5 | 0 | 2 | 3.7 | Fc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
168288343 | 190861 | 0 | None | 1 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 440 | 6 | 1 | 3 | 5.3 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5193214 | 190861 | 0 | None | 1 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 440 | 6 | 1 | 3 | 5.3 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
10236758 | 115272 | 3 | None | 208 | 13 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354065 | 115272 | 3 | None | 208 | 13 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
9954899 | 202758 | 15 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
CHEMBL72292 | 202758 | 15 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
44363755 | 121345 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 2.9 | COc1ccccc1N1CCN(CCC(=O)NC2CCc3c(cccc3OC)C2)CC1 | 10.1021/jm981041x | ||
CHEMBL359002 | 121345 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 2.9 | COc1ccccc1N1CCN(CCC(=O)NC2CCc3c(cccc3OC)C2)CC1 | 10.1021/jm981041x | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2010.07.034 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2010.07.034 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2010.07.034 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2010.07.034 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2010.07.034 | ||
168270809 | 189455 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 392 | 6 | 1 | 3 | 4.0 | Cc1cc(NC(=O)CN2CCC(OCc3ccc(F)c(F)c3)CC2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5172055 | 189455 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 392 | 6 | 1 | 3 | 4.0 | Cc1cc(NC(=O)CN2CCC(OCc3ccc(F)c(F)c3)CC2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
118719926 | 115280 | 0 | None | 102 | 8 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 358 | 9 | 1 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354073 | 115280 | 0 | None | 102 | 8 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 358 | 9 | 1 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
3191 | 102385 | 93 | None | -10 | 25 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
CHEMBL305660 | 102385 | 93 | None | -10 | 25 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
127032084 | 138811 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3cccc4cc[nH]c34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792813 | 138811 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3cccc4cc[nH]c34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127031500 | 138820 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3ncn4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792931 | 138820 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3ncn4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127031201 | 138845 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1ccc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793131 | 138845 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1ccc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
127031830 | 138902 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793906 | 138902 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
127031513 | 138944 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794287 | 138944 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)c1 | 10.1016/j.bmcl.2016.03.102 | ||
72737723 | 2541 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 10.1021/ml500267c | ||
8440 | 2541 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 10.1021/ml500267c | ||
CHEMBL3335556 | 2541 | 1 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 10.1021/ml500267c | ||
9904205 | 204135 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
CHEMBL83658 | 204135 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
9904205 | 204135 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
CHEMBL83658 | 204135 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
10594723 | 16863 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL125455 | 16863 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
163322330 | 190106 | 3 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5182191 | 190106 | 3 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
168287664 | 191056 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3cn4ccccc4n3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5196102 | 191056 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3cn4ccccc4n3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
168273063 | 189691 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5175728 | 189691 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
16094666 | 81315 | 2 | None | 52 | 3 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL216393 | 81315 | 2 | None | 52 | 3 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
621 | 906 | 64 | None | -8 | 72 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
83 | 906 | 64 | None | -8 | 72 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058225d | ||
38 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058225d | ||
722 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058225d | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058225d | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058225d | ||
168293190 | 191532 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 363 | 5 | 0 | 2 | 5.5 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(Cl)c(Cl)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5203595 | 191532 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 363 | 5 | 0 | 2 | 5.5 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(Cl)c(Cl)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
1613 | 2316 | 44 | None | -2 | 44 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
205 | 2316 | 44 | None | -2 | 44 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
3964 | 2316 | 44 | None | -2 | 44 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
CHEMBL831 | 2316 | 44 | None | -2 | 44 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
DB00408 | 2316 | 44 | None | -2 | 44 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
44318454 | 204290 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
CHEMBL84931 | 204290 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
10894144 | 110070 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 3.5 | N#Cc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 | 10.1021/jm010878g | ||
CHEMBL325258 | 110070 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 3.5 | N#Cc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 | 10.1021/jm010878g | ||
168277992 | 189535 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1cnc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5173368 | 189535 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1cnc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
100 | 3745 | 52 | None | -8 | 55 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
2637 | 3745 | 52 | None | -8 | 55 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
5452 | 3745 | 52 | None | -8 | 55 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
CHEMBL479 | 3745 | 52 | None | -8 | 55 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
DB00679 | 3745 | 52 | None | -8 | 55 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
168269421 | 189369 | 0 | None | 6 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 5.3 | Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5170670 | 189369 | 0 | None | 6 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 5.3 | Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
20354789 | 114026 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 281 | 5 | 0 | 2 | 3.5 | c1ccc(CCC2CN(Cc3ccccc3)CCO2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335544 | 114026 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 281 | 5 | 0 | 2 | 3.5 | c1ccc(CCC2CN(Cc3ccccc3)CCO2)cc1 | 10.1021/ml500267c | ||
10026300 | 167271 | 15 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 2 | 0 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
CHEMBL430798 | 167271 | 15 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 2 | 0 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
93601125 | 138821 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1OC | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792941 | 138821 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1OC | 10.1016/j.bmcl.2016.03.102 | ||
127053198 | 138842 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 317 | 5 | 0 | 3 | 3.6 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793112 | 138842 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 317 | 5 | 0 | 3 | 3.6 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127029390 | 138953 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794421 | 138953 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
118719926 | 115280 | 0 | None | 102 | 8 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 358 | 9 | 1 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354073 | 115280 | 0 | None | 102 | 8 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 358 | 9 | 1 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
168282745 | 190501 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5187721 | 190501 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
4189 | 205195 | 91 | None | -33 | 34 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL1559 | 205195 | 91 | None | -33 | 34 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL91 | 205195 | 91 | None | -33 | 34 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058018d | ||
38 | 944 | 89 | None | -13 | 91 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058018d | ||
722 | 944 | 89 | None | -13 | 91 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058018d | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058018d | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm058018d | ||
168297637 | 191725 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3ncc4ccccn34)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5206427 | 191725 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3ncc4ccccn34)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
21186194 | 201544 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 360 | 5 | 0 | 5 | 3.5 | COc1ccccc1-c1cccc(CN2CCN(c3ncccn3)CC2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL64487 | 201544 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 360 | 5 | 0 | 5 | 3.5 | COc1ccccc1-c1cccc(CN2CCN(c3ncccn3)CC2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
10739194 | 116326 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 4.9 | COc1c(Cl)cc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/jm990562x | ||
CHEMBL1202204 | 116326 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 4.9 | COc1c(Cl)cc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/jm990562x | ||
CHEMBL337951 | 116326 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 4.9 | COc1c(Cl)cc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/jm990562x | ||
127053215 | 138894 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 4 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793858 | 138894 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 4 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
72737744 | 114020 | 0 | None | 64 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335538 | 114020 | 0 | None | 64 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
168275962 | 190025 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5180979 | 190025 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
10713599 | 19204 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1cc(Cl)cc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
CHEMBL1202225 | 19204 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1cc(Cl)cc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
CHEMBL129324 | 19204 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1cc(Cl)cc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
168275089 | 189902 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179198 | 189902 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
168279825 | 190222 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5183902 | 190222 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
168283295 | 190641 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.6 | Cc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5189986 | 190641 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.6 | Cc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
168291848 | 191276 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3ncn4ccccc34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5199552 | 191276 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3ncn4ccccc34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
137640201 | 156419 | 2 | None | 177 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 362 | 6 | 0 | 2 | 4.3 | O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4072818 | 156419 | 2 | None | 177 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 362 | 6 | 0 | 2 | 4.3 | O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
168290895 | 191401 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.5 | Cn1ncc2cc(CN3CCC(OCc4ccc(Cl)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5201507 | 191401 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.5 | Cn1ncc2cc(CN3CCC(OCc4ccc(Cl)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
168292124 | 191427 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5201917 | 191427 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
44342270 | 9837 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 355 | 3 | 1 | 4 | 4.5 | Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1 | 10.1021/jm010878g | ||
CHEMBL114484 | 9837 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 355 | 3 | 1 | 4 | 4.5 | Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1 | 10.1021/jm010878g | ||
21186143 | 201587 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 360 | 5 | 0 | 5 | 3.5 | COc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL64671 | 201587 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 360 | 5 | 0 | 5 | 3.5 | COc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm990562x | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm990562x | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm990562x | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm990562x | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm990562x | ||
9797161 | 116393 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL1204119 | 116393 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL338337 | 116393 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
127032086 | 138792 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 337 | 5 | 0 | 5 | 2.9 | Cn1ncc2cc(CN3CCO[C@H](COc4ccccc4)C3)ccc21 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792637 | 138792 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 337 | 5 | 0 | 5 | 2.9 | Cn1ncc2cc(CN3CCO[C@H](COc4ccccc4)C3)ccc21 | 10.1016/j.bmcl.2016.03.102 | ||
72737728 | 114021 | 0 | None | 60 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 311 | 6 | 0 | 3 | 3.5 | COc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335539 | 114021 | 0 | None | 60 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 311 | 6 | 0 | 3 | 3.5 | COc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
168292951 | 191550 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5203807 | 191550 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
176 | 394 | 63 | None | -4 | 31 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
2157 | 394 | 63 | None | -4 | 31 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
2566 | 394 | 63 | None | -4 | 31 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
CHEMBL633 | 394 | 63 | None | -4 | 31 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
DB01118 | 394 | 63 | None | -4 | 31 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
53320010 | 56370 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2010.12.007 | ||
CHEMBL1642117 | 56370 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2010.12.007 | ||
127031832 | 138885 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793782 | 138885 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
127030909 | 138951 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 367 | 6 | 0 | 4 | 3.9 | FC(F)(F)Oc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794375 | 138951 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 367 | 6 | 0 | 4 | 3.9 | FC(F)(F)Oc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
60149678 | 114019 | 0 | None | 229 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CC[C@@H]2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335537 | 114019 | 0 | None | 229 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CC[C@@H]2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
42 | 2032 | 50 | None | - | 17 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm040792y | ||
56971 | 2032 | 50 | None | - | 17 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm040792y | ||
CHEMBL8412 | 2032 | 50 | None | - | 17 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 401 | 6 | 0 | 7 | 1.2 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 | 10.1021/jm040792y | ||
168279082 | 190139 | 0 | None | -1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5182602 | 190139 | 0 | None | -1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
168280464 | 190142 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 3.8 | Cc1ccccc1CO[C@H]1CCCN(Cc2cn3ccccc3n2)C1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5182635 | 190142 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 3.8 | Cc1ccccc1CO[C@H]1CCCN(Cc2cn3ccccc3n2)C1 | 10.1016/j.bmcl.2022.128615 | ||
45109862 | 7353 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 5.2 | Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmcl.2010.01.093 | ||
CHEMBL1086626 | 7353 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 5.2 | Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmcl.2010.01.093 | ||
168271806 | 189925 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179482 | 189925 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
10981761 | 110149 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 379 | 3 | 1 | 6 | 2.6 | O=C1NCN(c2ccccc2)C12CCN(Cc1ccc3nsnc3c1)CC2 | 10.1021/jm010878g | ||
CHEMBL325750 | 110149 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 379 | 3 | 1 | 6 | 2.6 | O=C1NCN(c2ccccc2)C12CCN(Cc1ccc3nsnc3c1)CC2 | 10.1021/jm010878g | ||
127031831 | 138810 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792805 | 138810 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
10425450 | 199 | 23 | None | -1 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
3301 | 199 | 23 | None | -1 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL375596 | 199 | 23 | None | -1 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
168280776 | 190564 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5188602 | 190564 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
6466372 | 169495 | 12 | None | 93 | 3 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443054 | 169495 | 12 | None | 93 | 3 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168275381 | 189676 | 0 | None | 4 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1ncc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5175548 | 189676 | 0 | None | 4 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1ncc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
2812 | 4711 | 96 | None | -39 | 34 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
CHEMBL104 | 4711 | 96 | None | -39 | 34 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
168280974 | 190269 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5184607 | 190269 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
21186186 | 198946 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL59942 | 198946 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
44336061 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1021/jm058225d | ||
CHEMBL320597 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1021/jm058225d | ||
10381889 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
CHEMBL315772 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
10381889 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
CHEMBL315772 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
10643697 | 120610 | 1 | None | 10 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.6 | COc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL357448 | 120610 | 1 | None | 10 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.6 | COc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
10450082 | 101844 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 342 | 3 | 0 | 4 | 3.4 | c1cnc(N2CCN(Cc3cccc4c3Cc3ccccc3-4)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL303519 | 101844 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 342 | 3 | 0 | 4 | 3.4 | c1cnc(N2CCN(Cc3cccc4c3Cc3ccccc3-4)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
168294958 | 191806 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.2 | COc1ccc(CN2CCC[C@H](OCc3cccc(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5207898 | 191806 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.2 | COc1ccc(CN2CCC[C@H](OCc3cccc(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
168289523 | 190903 | 0 | None | 5 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 422 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5193761 | 190903 | 0 | None | 5 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 422 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
168285068 | 190987 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3ncc4ccccn34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5195130 | 190987 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3ncc4ccccn34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
127027237 | 138856 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 314 | 6 | 0 | 5 | 2.4 | COc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793264 | 138856 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 314 | 6 | 0 | 5 | 2.4 | COc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
168275717 | 189625 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3ncc4ccccn34)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5174731 | 189625 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3ncc4ccccn34)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm981041x | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm981041x | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm981041x | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm981041x | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm981041x | ||
72737730 | 114028 | 0 | None | 42 | 3 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335554 | 114028 | 0 | None | 42 | 3 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
2274 | 3124 | 53 | None | -56 | 32 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
4917 | 3124 | 53 | None | -56 | 32 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
7279 | 3124 | 53 | None | -56 | 32 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
CHEMBL728 | 3124 | 53 | None | -56 | 32 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
DB00433 | 3124 | 53 | None | -56 | 32 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
155568411 | 175506 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 331 | 4 | 1 | 5 | 1.9 | O=C(CN1CCN(c2ccc(Cl)cn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4591118 | 175506 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 331 | 4 | 1 | 5 | 1.9 | O=C(CN1CCN(c2ccc(Cl)cn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
168281091 | 190477 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(C)cc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5187429 | 190477 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(C)cc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
21186148 | 200504 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 349 | 4 | 0 | 5 | 3.0 | Fc1ccc(-c2cncc(CN3CCN(c4cnccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL60957 | 200504 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 349 | 4 | 0 | 5 | 3.0 | Fc1ccc(-c2cncc(CN3CCN(c4cnccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
10108561 | 112445 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 295 | 2 | 0 | 4 | 2.8 | CN(C)CC1CC2c3ccccc3Cc3ccncc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
CHEMBL331077 | 112445 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 295 | 2 | 0 | 4 | 2.8 | CN(C)CC1CC2c3ccccc3Cc3ccncc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
155568867 | 175580 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4592753 | 175580 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
127028183 | 138786 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 366 | 6 | 0 | 5 | 3.2 | COc1ccc(CN2CCO[C@H](COc3cccc(F)n3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792532 | 138786 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 366 | 6 | 0 | 5 | 3.2 | COc1ccc(CN2CCO[C@H](COc3cccc(F)n3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
127032085 | 138858 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 363 | 5 | 0 | 5 | 3.3 | FC1(F)Oc2ccc(CN3CCO[C@H](COc4ccccc4)C3)cc2O1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793266 | 138858 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 363 | 5 | 0 | 5 | 3.3 | FC1(F)Oc2ccc(CN3CCO[C@H](COc4ccccc4)C3)cc2O1 | 10.1016/j.bmcl.2016.03.102 | ||
155513053 | 169131 | 0 | None | 6 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4437912 | 169131 | 0 | None | 6 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
127027238 | 138881 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3ccccn3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793709 | 138881 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3ccccn3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
45482789 | 197247 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 428 | 4 | 2 | 2 | 4.5 | CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1 | 10.1016/j.bmcl.2009.09.002 | ||
CHEMBL584554 | 197247 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 428 | 4 | 2 | 2 | 4.5 | CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1 | 10.1016/j.bmcl.2009.09.002 | ||
127027905 | 138926 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 327 | 5 | 0 | 3 | 4.3 | Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794079 | 138926 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 327 | 5 | 0 | 3 | 4.3 | Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
135418440 | 11963 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 351 | 5 | 1 | 6 | 2.3 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1183663 | 11963 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 351 | 5 | 1 | 6 | 2.3 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL310311 | 11963 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 351 | 5 | 1 | 6 | 2.3 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
168296363 | 191919 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1ncc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5209344 | 191919 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1ncc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
10092041 | 164980 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | COc1ccc2c(c1)C(CCCN1CCN(c3ccccc3OC)CC1)CCC2 | 10.1021/jm981041x | ||
CHEMBL424125 | 164980 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | COc1ccc2c(c1)C(CCCN1CCN(c3ccccc3OC)CC1)CCC2 | 10.1021/jm981041x | ||
11730467 | 10925 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
CHEMBL117537 | 10925 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
10688858 | 17911 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3cccc(Cl)c3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202223 | 17911 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3cccc(Cl)c3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL126793 | 17911 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3cccc(Cl)c3)CC2)cc1 | 10.1021/jm990562x | ||
131396 | 205008 | 6 | None | 1 | 5 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 4.6 | CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
CHEMBL89934 | 205008 | 6 | None | 1 | 5 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 4.6 | CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
44304600 | 201573 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 344 | 3 | 0 | 5 | 3.7 | c1cnc(N2CCN(Cc3cccc4c3oc3ccccc34)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL64622 | 201573 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 344 | 3 | 0 | 5 | 3.7 | c1cnc(N2CCN(Cc3cccc4c3oc3ccccc34)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
72737767 | 114022 | 4 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335540 | 114022 | 4 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
21186115 | 201018 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 4.3 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4F)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL61682 | 201018 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 4.3 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4F)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
9949655 | 201567 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 336 | 4 | 0 | 5 | 3.5 | c1cnc(N2CCN(Cc3cccc(-c4ccsc4)c3)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL64597 | 201567 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 336 | 4 | 0 | 5 | 3.5 | c1cnc(N2CCN(Cc3cccc(-c4ccsc4)c3)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
10666005 | 17770 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 4.3 | COc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202211 | 17770 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 4.3 | COc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL126032 | 17770 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 4.3 | COc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
10829708 | 17860 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202216 | 17860 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL126509 | 17860 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
9799123 | 5543 | 0 | None | 35 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1021/jm058225d | ||
CHEMBL107742 | 5543 | 0 | None | 35 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1021/jm058225d | ||
11726532 | 96578 | 0 | None | -2 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 368 | 8 | 0 | 5 | 3.5 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL26677 | 96578 | 0 | None | -2 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 368 | 8 | 0 | 5 | 3.5 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
10688859 | 17910 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202222 | 17910 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL126792 | 17910 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 4.4 | Fc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990562x | ||
44363676 | 39796 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 2.9 | COc1ccc2c(c1)CC(NC(=O)CCN1CCN(c3ccccc3OC)CC1)CC2 | 10.1021/jm981041x | ||
CHEMBL147897 | 39796 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 2.9 | COc1ccc2c(c1)CC(NC(=O)CCN1CCN(c3ccccc3OC)CC1)CC2 | 10.1021/jm981041x | ||
CHEMBL2373210 | 39796 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 2.9 | COc1ccc2c(c1)CC(NC(=O)CCN1CCN(c3ccccc3OC)CC1)CC2 | 10.1021/jm981041x | ||
10572037 | 120509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(Cc3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL2373204 | 120509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(Cc3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL356581 | 120509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(Cc3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
135612922 | 143169 | 2 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 336 | 3 | 2 | 5 | 2.0 | O=c1[nH]c(CN2CCN(c3ccc(O)cc3)CC2)nc2ccccc12 | nan | ||
CHEMBL3900329 | 143169 | 2 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 336 | 3 | 2 | 5 | 2.0 | O=c1[nH]c(CN2CCN(c3ccc(O)cc3)CC2)nc2ccccc12 | nan | ||
19426635 | 203881 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 280 | 2 | 1 | 3 | 3.1 | CNCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
CHEMBL81485 | 203881 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 280 | 2 | 1 | 3 | 3.1 | CNCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
168271259 | 189921 | 0 | None | 2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cc1nc(CN2CCC(OCc3cccc(C(F)(F)F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179459 | 189921 | 0 | None | 2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cc1nc(CN2CCC(OCc3cccc(C(F)(F)F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
163322331 | 191617 | 3 | None | 8 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 4.5 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(F)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5204764 | 191617 | 3 | None | 8 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 4.5 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(F)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
10688561 | 116367 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 340 | 4 | 0 | 2 | 4.6 | Cc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202210 | 116367 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 340 | 4 | 0 | 2 | 4.6 | Cc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL338183 | 116367 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 340 | 4 | 0 | 2 | 4.6 | Cc1cc(Cl)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
4797946 | 169856 | 8 | None | 165 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4448320 | 169856 | 8 | None | 165 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
3117 | 206106 | 100 | None | -2 | 16 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
CHEMBL964 | 206106 | 100 | None | -2 | 16 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
168268918 | 189414 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 4.7 | Cc1cccc(CO[C@H]2CCCN(Cc3cc4ccc(Cl)cc4[nH]3)C2)n1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5171398 | 189414 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 4.7 | Cc1cccc(CO[C@H]2CCCN(Cc3cc4ccc(Cl)cc4[nH]3)C2)n1 | 10.1016/j.bmcl.2022.128615 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2013.03.016 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2013.03.016 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2013.03.016 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2013.03.016 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2013.03.016 | ||
127053222 | 138839 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793072 | 138839 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
168270455 | 189440 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 5 | 1 | 2 | 5.8 | Fc1cc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5171772 | 189440 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 5 | 1 | 2 | 5.8 | Fc1cc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
135 | 2496 | 38 | None | - | 57 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
1796 | 2496 | 38 | None | - | 57 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
4184 | 2496 | 38 | None | - | 57 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
CHEMBL6437 | 2496 | 38 | None | - | 57 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
DB06148 | 2496 | 38 | None | - | 57 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
11071079 | 110104 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
CHEMBL325516 | 110104 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
168294968 | 191821 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3cn4ccccc4n3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5208124 | 191821 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3cn4ccccc4n3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
127028505 | 138803 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792731 | 138803 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
4223 | 3929 | 88 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
6918314 | 3929 | 88 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
7427 | 3929 | 88 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
CHEMBL439849 | 3929 | 88 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
DB06684 | 3929 | 88 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
168291477 | 191284 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccccc3C)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5199649 | 191284 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccccc3C)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
19964406 | 114017 | 3 | None | 75 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CCC2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335535 | 114017 | 3 | None | 75 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CCC2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
53320009 | 56369 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1 | 10.1016/j.bmcl.2010.12.007 | ||
CHEMBL1642116 | 56369 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 435 | 3 | 0 | 5 | 3.4 | CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1 | 10.1016/j.bmcl.2010.12.007 | ||
72737772 | 114023 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 295 | 5 | 0 | 2 | 3.8 | Cc1ccccc1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
CHEMBL3335541 | 114023 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 295 | 5 | 0 | 2 | 3.8 | Cc1ccccc1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
10782111 | 17705 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
CHEMBL1202217 | 17705 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
CHEMBL125910 | 17705 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
127029388 | 138809 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1cc(CN2CCO[C@H](COc3cccc(F)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792803 | 138809 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1cc(CN2CCO[C@H](COc3cccc(F)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
45361874 | 169454 | 2 | None | 48 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4442548 | 169454 | 2 | None | 48 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168277394 | 189807 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5177641 | 189807 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
127031516 | 138779 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792438 | 138779 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
92988697 | 138937 | 1 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794199 | 138937 | 1 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
92984956 | 138950 | 1 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccc(OC)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794363 | 138950 | 1 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccc(OC)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
46885213 | 8375 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 549 | 8 | 2 | 5 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | ||
CHEMBL1093802 | 8375 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 549 | 8 | 2 | 5 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | ||
155530763 | 171003 | 0 | None | 9 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4464861 | 171003 | 0 | None | 9 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
127031833 | 138865 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1cccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c12 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793347 | 138865 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1cccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c12 | 10.1016/j.bmcl.2016.03.102 | ||
54477 | 84230 | 34 | None | -14 | 22 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | 10.1021/jm990562x | ||
CHEMBL22242 | 84230 | 34 | None | -14 | 22 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | 10.1021/jm990562x | ||
72737725 | 114027 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.8 | Fc1cccc(F)c1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
CHEMBL3335545 | 114027 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.8 | Fc1cccc(F)c1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
127029387 | 138877 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793612 | 138877 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
72737734 | 114024 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1cccc(CN2CCOC(CCc3ccccc3)C2)c1 | 10.1021/ml500267c | ||
CHEMBL3335542 | 114024 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1cccc(CN2CCOC(CCc3ccccc3)C2)c1 | 10.1021/ml500267c | ||
10034684 | 69064 | 63 | None | 18 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 135 | 0 | 2 | 2 | 1.4 | Oc1ccc2c(c1)CCN2 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL19331 | 69064 | 63 | None | 18 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 135 | 0 | 2 | 2 | 1.4 | Oc1ccc2c(c1)CCN2 | 10.1016/S0960-894X(97)00194-7 | ||
155562395 | 175375 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4587925 | 175375 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
54577891 | 66242 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 471 | 6 | 1 | 5 | 4.3 | Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | ||
CHEMBL1852516 | 66242 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 471 | 6 | 1 | 5 | 4.3 | Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | ||
CHEMBL3216758 | 66242 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 471 | 6 | 1 | 5 | 4.3 | Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1 | 10.1021/jm200682b | ||
17888044 | 201234 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL62829 | 201234 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
10832895 | 120481 | 8 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1ccccc1C(=O)NCCN1CCN(c2ccccc2OC)CC1 | 10.1021/jm981041x | ||
CHEMBL356358 | 120481 | 8 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1ccccc1C(=O)NCCN1CCN(c2ccccc2OC)CC1 | 10.1021/jm981041x | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2016.03.006 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2016.03.006 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2016.03.006 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2016.03.006 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2016.03.006 | ||
127031518 | 138869 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793389 | 138869 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
127029995 | 138967 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794529 | 138967 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1F | 10.1016/j.bmcl.2016.03.102 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
155511803 | 169038 | 0 | None | 229 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 342 | 4 | 1 | 2 | 4.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4436479 | 169038 | 0 | None | 229 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 342 | 4 | 1 | 2 | 4.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
155536720 | 171621 | 0 | None | 77 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473652 | 171621 | 0 | None | 77 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168270563 | 189357 | 0 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5170381 | 189357 | 0 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
11035765 | 9795 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 359 | 6 | 2 | 6 | 3.3 | Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2 | 10.1021/jm010878g | ||
CHEMBL114280 | 9795 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 359 | 6 | 2 | 6 | 3.3 | Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2 | 10.1021/jm010878g | ||
11793971 | 17783 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 376 | 4 | 1 | 3 | 4.6 | Oc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202202 | 17783 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 376 | 4 | 1 | 3 | 4.6 | Oc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL126126 | 17783 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 376 | 4 | 1 | 3 | 4.6 | Oc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
109030515 | 175412 | 1 | None | 12 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4588808 | 175412 | 1 | None | 12 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168292271 | 191292 | 0 | None | 5 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 424 | 6 | 1 | 3 | 5.1 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(Cl)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5199815 | 191292 | 0 | None | 5 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 424 | 6 | 1 | 3 | 5.1 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(Cl)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
168295019 | 191901 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5209079 | 191901 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
10668173 | 19243 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 4.9 | COc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202206 | 19243 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 4.9 | COc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL129556 | 19243 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 4.9 | COc1ccc([C@H]2C[C@@H]2CN2CCN(c3ccc(Cl)cc3Cl)CC2)cc1 | 10.1021/jm990562x | ||
127053214 | 138819 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 311 | 5 | 0 | 3 | 3.6 | Cc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792923 | 138819 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 311 | 5 | 0 | 3 | 3.6 | Cc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
155515982 | 169443 | 0 | None | 6 | 17 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4442460 | 169443 | 0 | None | 6 | 17 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
127031829 | 138898 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793890 | 138898 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
127028182 | 138932 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 5 | 0 | 4 | 3.2 | Fc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)n1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794158 | 138932 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 5 | 0 | 4 | 3.2 | Fc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)n1 | 10.1016/j.bmcl.2016.03.102 | ||
127029386 | 138867 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccc(F)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793375 | 138867 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccc(F)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
44363656 | 35247 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.5 | COc1ccc2c(c1)CC(NC(=O)CN1CCN(c3ccccc3OC)CC1)CC2 | 10.1021/jm981041x | ||
CHEMBL143835 | 35247 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.5 | COc1ccc2c(c1)CC(NC(=O)CN1CCN(c3ccccc3OC)CC1)CC2 | 10.1021/jm981041x | ||
CHEMBL2373208 | 35247 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.5 | COc1ccc2c(c1)CC(NC(=O)CN1CCN(c3ccccc3OC)CC1)CC2 | 10.1021/jm981041x | ||
71717830 | 85556 | 0 | None | 9 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 433 | 5 | 7 | 9 | -0.3 | OC[C@H]1O[C@H](Oc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)[C@H](O)[C@H](O)[C@H]1O | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL2303762 | 85556 | 0 | None | 9 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 433 | 5 | 7 | 9 | -0.3 | OC[C@H]1O[C@H](Oc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)[C@H](O)[C@H](O)[C@H]1O | 10.1016/S0960-894X(97)00194-7 | ||
168275515 | 189911 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.1 | Cc1nc(CN2CCC(OCc3ccc(F)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179340 | 189911 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.1 | Cc1nc(CN2CCC(OCc3ccc(F)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
10851217 | 118020 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 292 | 4 | 0 | 2 | 3.6 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL341497 | 118020 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 292 | 4 | 0 | 2 | 3.6 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
44304314 | 102219 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 342 | 3 | 0 | 4 | 3.4 | c1cnc(N2CCN(Cc3cccc4c3-c3ccccc3C4)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL304692 | 102219 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 342 | 3 | 0 | 4 | 3.4 | c1cnc(N2CCN(Cc3cccc4c3-c3ccccc3C4)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
155559617 | 174312 | 0 | None | 9 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4563944 | 174312 | 0 | None | 9 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
135514603 | 202414 | 13 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 474 | 2 | 1 | 7 | 4.0 | CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
CHEMBL70319 | 202414 | 13 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 474 | 2 | 1 | 7 | 4.0 | CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00361-8 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00361-8 | ||
5615 | 3836 | 4 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 10.1016/s0960-894x(98)00361-8 | ||
5781 | 3836 | 4 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL1179189 | 3836 | 4 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 10.1016/s0960-894x(98)00361-8 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm990562x | ||
9901894 | 162864 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202220 | 162864 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL419610 | 162864 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
11301655 | 198 | 31 | None | 245 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/jm030505a | ||
8441 | 198 | 31 | None | 245 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/jm030505a | ||
CHEMBL127257 | 198 | 31 | None | 245 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/jm030505a | ||
127031515 | 138904 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL3793910 | 138904 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
135620651 | 143975 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 3 | 2 | 5 | 2.0 | O=c1[nH]c(CN2CCN(c3cccc(O)c3)CC2)nc2ccccc12 | nan | ||
CHEMBL3906995 | 143975 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 3 | 2 | 5 | 2.0 | O=c1[nH]c(CN2CCN(c3cccc(O)c3)CC2)nc2ccccc12 | nan | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
127053220 | 138837 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.2 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793062 | 138837 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.2 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
11005810 | 10367 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
CHEMBL116463 | 10367 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
51003551 | 56376 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 449 | 3 | 0 | 5 | 3.8 | CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.12.007 | ||
CHEMBL1642123 | 56376 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 449 | 3 | 0 | 5 | 3.8 | CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2010.12.007 | ||
127031515 | 138904 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793910 | 138904 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
10803754 | 17923 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 294 | 4 | 0 | 4 | 2.4 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ncccn3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1203257 | 17923 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 294 | 4 | 0 | 4 | 2.4 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ncccn3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL126847 | 17923 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 294 | 4 | 0 | 4 | 2.4 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ncccn3)CC2)cc1 | 10.1021/jm990562x | ||
21186102 | 100310 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 360 | 5 | 0 | 5 | 3.5 | COc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL292943 | 100310 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 360 | 5 | 0 | 5 | 3.5 | COc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
10049758 | 202939 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 457 | 2 | 0 | 7 | 3.7 | CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
CHEMBL73589 | 202939 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 457 | 2 | 0 | 7 | 3.7 | CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
137640201 | 156419 | 2 | None | 177 | 13 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 362 | 6 | 0 | 2 | 4.3 | O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4072818 | 156419 | 2 | None | 177 | 13 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 362 | 6 | 0 | 2 | 4.3 | O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
168287735 | 191208 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5198353 | 191208 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
127031519 | 138793 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.7 | CSc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792638 | 138793 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.7 | CSc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127053221 | 138801 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792728 | 138801 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
127032383 | 138873 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3ccc4[nH]ccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793438 | 138873 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3ccc4[nH]ccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
1212 | 1632 | 45 | None | -77 | 65 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
204 | 1632 | 45 | None | -77 | 65 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
3372 | 1632 | 45 | None | -77 | 65 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
CHEMBL726 | 1632 | 45 | None | -77 | 65 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
DB00623 | 1632 | 45 | None | -77 | 65 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
127032082 | 138787 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3cn4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792541 | 138787 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3cn4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
21186124 | 101742 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 347 | 4 | 0 | 3 | 4.2 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL302904 | 101742 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 347 | 4 | 0 | 3 | 4.2 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
9949655 | 201567 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 336 | 4 | 0 | 5 | 3.5 | c1cnc(N2CCN(Cc3cccc(-c4ccsc4)c3)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL64597 | 201567 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 336 | 4 | 0 | 5 | 3.5 | c1cnc(N2CCN(Cc3cccc(-c4ccsc4)c3)CC2)nc1 | 10.1016/s0960-894x(98)00361-8 | ||
10617133 | 17815 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.8 | COc1cc(F)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202214 | 17815 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.8 | COc1cc(F)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL126269 | 17815 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.8 | COc1cc(F)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
9820304 | 101599 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL1204116 | 101599 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL302075 | 101599 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
10236758 | 115272 | 3 | None | 208 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354065 | 115272 | 3 | None | 208 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991005d | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991005d | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991005d | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991005d | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991005d | ||
10385977 | 96882 | 0 | None | -5 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | COc1ccccc1N1CCN(CCCC2CCCc3c(OC)cccc32)CC1 | 10.1021/jm981041x | ||
CHEMBL26929 | 96882 | 0 | None | -5 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | COc1ccccc1N1CCN(CCCC2CCCc3c(OC)cccc32)CC1 | 10.1021/jm981041x | ||
2247 | 502 | 77 | None | -63 | 41 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
249 | 502 | 77 | None | -63 | 41 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
2603 | 502 | 77 | None | -63 | 41 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
CHEMBL296419 | 502 | 77 | None | -63 | 41 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
DB00637 | 502 | 77 | None | -63 | 41 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
127031508 | 138851 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793169 | 138851 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
155552185 | 173489 | 0 | None | 2 | 16 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4544086 | 173489 | 0 | None | 2 | 16 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
127053217 | 138788 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.1 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792556 | 138788 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.1 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
45278882 | 7371 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 9 | 1 | 4 | 6.1 | CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C | 10.1016/j.bmcl.2010.01.093 | ||
CHEMBL1086756 | 7371 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 9 | 1 | 4 | 6.1 | CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C | 10.1016/j.bmcl.2010.01.093 | ||
168274850 | 189562 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 405 | 6 | 0 | 5 | 4.4 | FC(F)(F)Oc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5173767 | 189562 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 405 | 6 | 0 | 5 | 4.4 | FC(F)(F)Oc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
168274755 | 190048 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1cnc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5181334 | 190048 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1cnc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
127032083 | 138917 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 323 | 5 | 1 | 4 | 2.8 | c1ccc(OC[C@@H]2CN(Cc3n[nH]c4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793996 | 138917 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 323 | 5 | 1 | 4 | 2.8 | c1ccc(OC[C@@H]2CN(Cc3n[nH]c4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
72198754 | 90449 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 | 10.1016/j.ejmech.2013.01.044 | ||
CHEMBL2392349 | 90449 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 8 | 0 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1 | 10.1016/j.ejmech.2013.01.044 | ||
10905740 | 110181 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 413 | 3 | 1 | 6 | 2.9 | O=c1[nH]c2ccccc2n(C2CCN(Cc3cc4c(cc3Cl)OCO4)CC2)c1=O | 10.1021/jm010878g | ||
CHEMBL325945 | 110181 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 413 | 3 | 1 | 6 | 2.9 | O=c1[nH]c2ccccc2n(C2CCN(Cc3cc4c(cc3Cl)OCO4)CC2)c1=O | 10.1021/jm010878g | ||
10615990 | 116802 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 324 | 4 | 0 | 2 | 4.1 | Cc1cc(F)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202209 | 116802 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 324 | 4 | 0 | 2 | 4.1 | Cc1cc(F)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL339674 | 116802 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 324 | 4 | 0 | 2 | 4.1 | Cc1cc(F)ccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
127053219 | 138934 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794174 | 138934 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
15840855 | 101619 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 349 | 4 | 0 | 5 | 3.0 | Fc1ccc(-c2cncc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL302183 | 101619 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 349 | 4 | 0 | 5 | 3.0 | Fc1ccc(-c2cncc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
21186186 | 198946 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL59942 | 198946 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
21186138 | 201010 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccc(-c2cncc(CN3CCN(c4ccccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL61657 | 201010 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccc(-c2cncc(CN3CCN(c4ccccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
21186115 | 201018 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 4.3 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4F)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL61682 | 201018 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 4.3 | Fc1ccc(-c2cncc(CN3CCN(c4ccccc4F)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
9797162 | 77938 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(CC3CC3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL2092961 | 77938 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(CC3CC3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL2109988 | 77938 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(CC3CC3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
10501113 | 36317 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 399 | 8 | 1 | 6 | 2.3 | COc1ccc(OC)c(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL144811 | 36317 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 399 | 8 | 1 | 6 | 2.3 | COc1ccc(OC)c(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm981041x | ||
10762827 | 121413 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(Cc3ccc(Cl)cc3)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL2373207 | 121413 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(Cc3ccc(Cl)cc3)CC2)c1 | 10.1021/jm981041x | ||
CHEMBL359051 | 121413 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(Cc3ccc(Cl)cc3)CC2)c1 | 10.1021/jm981041x | ||
10411988 | 21210 | 0 | None | -29 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 5.2 | CC1SC2(CCCC2)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
CHEMBL131482 | 21210 | 0 | None | -29 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 5.2 | CC1SC2(CCCC2)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
11113605 | 10407 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
CHEMBL116735 | 10407 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
10496095 | 116330 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1202224 | 116330 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL337983 | 116330 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 3.6 | COc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1 | 10.1021/jm990562x | ||
155536815 | 171641 | 0 | None | 33 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473792 | 171641 | 0 | None | 33 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1021/acs.jmedchem.9b00231 | ||
10739483 | 36391 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 395 | 6 | 0 | 6 | 4.2 | COc1cccc(-c2csc(CN3CCN(c4ccccc4OC)CC3)n2)c1 | 10.1021/jm981041x | ||
CHEMBL144868 | 36391 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 395 | 6 | 0 | 6 | 4.2 | COc1cccc(-c2csc(CN3CCN(c4ccccc4OC)CC3)n2)c1 | 10.1021/jm981041x | ||
CHEMBL2373206 | 36391 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 395 | 6 | 0 | 6 | 4.2 | COc1cccc(-c2csc(CN3CCN(c4ccccc4OC)CC3)n2)c1 | 10.1021/jm981041x | ||
127028181 | 138919 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 3.1 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(F)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794013 | 138919 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 3.1 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(F)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
10885636 | 110527 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
CHEMBL326263 | 110527 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
155563301 | 174678 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4572245 | 174678 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
5615 | 3836 | 4 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 10.1016/s0960-894x(98)00361-8 | ||
5781 | 3836 | 4 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL1179189 | 3836 | 4 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 10.1016/s0960-894x(98)00361-8 | ||
21186098 | 100077 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccccc1-c1cccc(CN2CCN(c3ncccn3)CC2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL291380 | 100077 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1ccccc1-c1cccc(CN2CCN(c3ncccn3)CC2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
21186192 | 100137 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 4.3 | Fc1ccc(-c2cncc(CN3CCN(c4ccc(F)cc4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL291824 | 100137 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 4.3 | Fc1ccc(-c2cncc(CN3CCN(c4ccc(F)cc4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
10615684 | 17857 | 0 | None | 4 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL1202208 | 17857 | 0 | None | 4 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
CHEMBL126493 | 17857 | 0 | None | 4 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 4.2 | Cc1ccc(N2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c(C)c1 | 10.1021/jm990562x | ||
9967140 | 17883 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202215 | 17883 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL126633 | 17883 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1ccccc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
127032384 | 138846 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793137 | 138846 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
10568183 | 17795 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
CHEMBL1202221 | 17795 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
CHEMBL126182 | 17795 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 326 | 4 | 0 | 2 | 4.3 | Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1 | 10.1021/jm990562x | ||
44363675 | 118748 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.5 | COc1ccccc1N1CCN(CC(=O)NC2CCc3c(cccc3OC)C2)CC1 | 10.1021/jm981041x | ||
CHEMBL2373209 | 118748 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.5 | COc1ccccc1N1CCN(CC(=O)NC2CCc3c(cccc3OC)C2)CC1 | 10.1021/jm981041x | ||
CHEMBL343620 | 118748 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.5 | COc1ccccc1N1CCN(CC(=O)NC2CCc3c(cccc3OC)C2)CC1 | 10.1021/jm981041x | ||
168286314 | 191063 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5196213 | 191063 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
15840855 | 101619 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 349 | 4 | 0 | 5 | 3.0 | Fc1ccc(-c2cncc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL302183 | 101619 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 349 | 4 | 0 | 5 | 3.0 | Fc1ccc(-c2cncc(CN3CCN(c4ncccn4)CC3)c2)cc1 | 10.1016/s0960-894x(98)00361-8 | ||
17888044 | 201234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
CHEMBL62829 | 201234 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.6 | Fc1cccc(-c2cccc(CN3CCN(c4ncccn4)CC3)c2)c1 | 10.1016/s0960-894x(98)00361-8 | ||
10808230 | 17877 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 4.3 | COc1ccc(Cl)cc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL1202205 | 17877 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 4.3 | COc1ccc(Cl)cc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
CHEMBL126604 | 17877 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 4.3 | COc1ccc(Cl)cc1N1CCN(C[C@H]2C[C@@H]2c2ccccc2)CC1 | 10.1021/jm990562x | ||
9820304 | 101599 | 0 | None | 12 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL1204116 | 101599 | 0 | None | 12 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
CHEMBL302075 | 101599 | 0 | None | 12 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1021/jm990562x | ||
10761040 | 117966 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1Cl | 10.1021/jm990562x | ||
CHEMBL1202213 | 117966 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1Cl | 10.1021/jm990562x | ||
CHEMBL341310 | 117966 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1cccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c1Cl | 10.1021/jm990562x | ||
14925759 | 157494 | 6 | None | 18 | 13 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4085780 | 157494 | 6 | None | 18 | 13 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
127029389 | 138913 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793984 | 138913 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
3198 | 203802 | 73 | None | -26 | 34 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL1201049 | 203802 | 73 | None | -26 | 34 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL808 | 203802 | 73 | None | -26 | 34 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
10948527 | 110867 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 365 | 3 | 1 | 5 | 2.3 | O=C1NCN(c2ccccc2)C12CCN(Cc1ccc3c(c1)OCO3)CC2 | 10.1021/jm010878g | ||
CHEMBL326962 | 110867 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 365 | 3 | 1 | 5 | 2.3 | O=C1NCN(c2ccccc2)C12CCN(Cc1ccc3c(c1)OCO3)CC2 | 10.1021/jm010878g | ||
135492584 | 11228 | 0 | None | 95 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 380 | 7 | 1 | 7 | 2.5 | c1cnc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1179503 | 11228 | 0 | None | 95 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 380 | 7 | 1 | 7 | 2.5 | c1cnc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL80645 | 11228 | 0 | None | 95 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 380 | 7 | 1 | 7 | 2.5 | c1cnc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
135481864 | 12244 | 0 | None | 112 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 350 | 5 | 1 | 5 | 2.9 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1185415 | 12244 | 0 | None | 112 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 350 | 5 | 1 | 5 | 2.9 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL412665 | 12244 | 0 | None | 112 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 350 | 5 | 1 | 5 | 2.9 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
168284020 | 190659 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.6 | Cc1nc(CN2CCC(OCc3ccc(Cl)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5190239 | 190659 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.6 | Cc1nc(CN2CCC(OCc3ccc(Cl)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
10780076 | 17821 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 293 | 4 | 0 | 3 | 3.0 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccn3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL1203260 | 17821 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 293 | 4 | 0 | 3 | 3.0 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccn3)CC2)cc1 | 10.1021/jm990562x | ||
CHEMBL126318 | 17821 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 293 | 4 | 0 | 3 | 3.0 | c1ccc([C@H]2C[C@@H]2CN2CCN(c3ccccn3)CC2)cc1 | 10.1021/jm990562x | ||
127031497 | 138961 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794469 | 138961 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
4452 | 2721 | 18 | None | -7 | 18 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1021/acs.jmedchem.9b00412 | ||
983 | 2721 | 18 | None | -7 | 18 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1021/acs.jmedchem.9b00412 | ||
CHEMBL20734 | 2721 | 18 | None | -7 | 18 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1021/acs.jmedchem.9b00412 | ||
45278805 | 7369 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 484 | 7 | 1 | 4 | 5.2 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C | 10.1016/j.bmcl.2010.01.093 | ||
CHEMBL1086754 | 7369 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 484 | 7 | 1 | 4 | 5.2 | Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C | 10.1016/j.bmcl.2010.01.093 | ||
164612037 | 184795 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL4860528 | 184795 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | ||
168290235 | 192366 | 0 | None | -5 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5201074 | 192366 | 0 | None | -5 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5222491 | 192366 | 0 | None | -5 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
168294767 | 192417 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5207281 | 192417 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5222802 | 192417 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
168295528 | 192429 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5206565 | 192429 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
CHEMBL5222872 | 192429 | 0 | None | -1 | 20 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
4452 | 2721 | 18 | None | -7 | 18 | Human | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1021/jm9601720 | ||
983 | 2721 | 18 | None | -7 | 18 | Human | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1021/jm9601720 | ||
CHEMBL20734 | 2721 | 18 | None | -7 | 18 | Human | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1021/jm9601720 | ||
9849682 | 94511 | 0 | None | -602 | 10 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 523 | 2 | 1 | 5 | 2.9 | CN1C[C@H](C(=O)N2CCN(c3cccc(=O)n3C)CC2)C[C@@H]2c3cccc4[nH]c(Br)c(c34)C[C@H]21 | 10.1016/j.bmcl.2007.12.030 | ||
CHEMBL254500 | 94511 | 0 | None | -602 | 10 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 523 | 2 | 1 | 5 | 2.9 | CN1C[C@H](C(=O)N2CCN(c3cccc(=O)n3C)CC2)C[C@@H]2c3cccc4[nH]c(Br)c(c34)C[C@H]21 | 10.1016/j.bmcl.2007.12.030 | ||
10162564 | 12433 | 0 | None | -218 | 8 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 475 | 7 | 0 | 3 | 5.1 | CN(CCC(=O)N1CCN(c2ccc(F)c(F)c2)CC1)CCC1c2ccccc2-c2ccccc21 | 10.1016/j.bmcl.2009.01.072 | ||
CHEMBL1186652 | 12433 | 0 | None | -218 | 8 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 475 | 7 | 0 | 3 | 5.1 | CN(CCC(=O)N1CCN(c2ccc(F)c(F)c2)CC1)CCC1c2ccccc2-c2ccccc21 | 10.1016/j.bmcl.2009.01.072 | ||
CHEMBL473763 | 12433 | 0 | None | -218 | 8 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 475 | 7 | 0 | 3 | 5.1 | CN(CCC(=O)N1CCN(c2ccc(F)c(F)c2)CC1)CCC1c2ccccc2-c2ccccc21 | 10.1016/j.bmcl.2009.01.072 | ||
3251 | 4009 | 50 | None | -43 | 12 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/acs.jmedchem.2c00633 | ||
5684 | 4009 | 50 | None | -43 | 12 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/acs.jmedchem.2c00633 | ||
80 | 4009 | 50 | None | -43 | 12 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/acs.jmedchem.2c00633 | ||
CHEMBL31354 | 4009 | 50 | None | -43 | 12 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/acs.jmedchem.2c00633 | ||
11724450 | 123330 | 4 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184158 | 123330 | 4 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL362542 | 123330 | 4 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
17955460 | 176201 | 0 | None | -630 | 9 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 491 | 7 | 0 | 4 | 5.3 | CN(CCC(=O)N1CCN(c2ccc(F)c(F)c2)CC1)CCC1c2ccccc2Oc2ccccc21 | 10.1016/j.bmcl.2009.01.072 | ||
CHEMBL460542 | 176201 | 0 | None | -630 | 9 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 491 | 7 | 0 | 4 | 5.3 | CN(CCC(=O)N1CCN(c2ccc(F)c(F)c2)CC1)CCC1c2ccccc2Oc2ccccc21 | 10.1016/j.bmcl.2009.01.072 | ||
2030 | 3615 | 7 | None | -7 | 10 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 3.0 | COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-] | 10.1016/j.bmcl.2009.01.072 | ||
5311377 | 3615 | 7 | None | -7 | 10 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 3.0 | COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-] | 10.1016/j.bmcl.2009.01.072 | ||
CHEMBL251541 | 3615 | 7 | None | -7 | 10 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 3.0 | COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-] | 10.1016/j.bmcl.2009.01.072 | ||
2030 | 3615 | 7 | None | -7 | 10 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 3.0 | COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-] | 10.1016/j.bmcl.2007.04.086 | ||
5311377 | 3615 | 7 | None | -7 | 10 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 3.0 | COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-] | 10.1016/j.bmcl.2007.04.086 | ||
CHEMBL251541 | 3615 | 7 | None | -7 | 10 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 3.0 | COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-] | 10.1016/j.bmcl.2007.04.086 | ||
44447073 | 94114 | 0 | None | -208 | 10 | Human | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 534 | 2 | 1 | 6 | 3.8 | CN1C[C@H](C(=O)N2CCN(c3ccc4nonc4c3)CC2)C[C@@H]2c3cccc4[nH]c(Br)c(c34)C[C@H]21 | 10.1016/j.bmcl.2007.12.030 | ||
CHEMBL251835 | 94114 | 0 | None | -208 | 10 | Human | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 534 | 2 | 1 | 6 | 3.8 | CN1C[C@H](C(=O)N2CCN(c3ccc4nonc4c3)CC2)C[C@@H]2c3cccc4[nH]c(Br)c(c34)C[C@H]21 | 10.1016/j.bmcl.2007.12.030 | ||
11729231 | 49344 | 0 | None | 1584 | 4 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 3.6 | COc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL156599 | 49344 | 0 | None | 1584 | 4 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 407 | 6 | 1 | 4 | 3.6 | COc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
11131951 | 49651 | 1 | None | 363 | 4 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 2.6 | COc1cccc(C(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL156845 | 49651 | 1 | None | 363 | 4 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 2.6 | COc1cccc(C(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1 | 10.1021/jm020952a | ||
4257 | 77868 | 26 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 478 | 4 | 1 | 4 | 4.7 | O=C1NC2CCCCN2C12CCN(CCCN1c3ccccc3CCc3ccc(Cl)cc31)CC2 | 10.1016/j.ejmech.2019.111569 | ||
CHEMBL2106650 | 77868 | 26 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 478 | 4 | 1 | 4 | 4.7 | O=C1NC2CCCCN2C12CCN(CCCN1c3ccccc3CCc3ccc(Cl)cc31)CC2 | 10.1016/j.ejmech.2019.111569 | ||
3504099 | 91728 | 5 | None | 3388 | 3 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 335 | 5 | 1 | 3 | 3.9 | CCOc1ccccc1N1CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420894 | 91728 | 5 | None | 3388 | 3 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 335 | 5 | 1 | 3 | 3.9 | CCOc1ccccc1N1CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
10948748 | 50185 | 0 | None | 676 | 3 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL157322 | 50185 | 0 | None | 676 | 3 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1021/jm020952a | ||
3626837 | 205584 | 8 | None | 125 | 4 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL93403 | 205584 | 8 | None | 125 | 4 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
3626837 | 205584 | 8 | None | 125 | 4 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL93403 | 205584 | 8 | None | 125 | 4 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
16363 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1016/j.bmc.2016.06.011 | ||
312 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1016/j.bmc.2016.06.011 | ||
9215 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL297302 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1016/j.bmc.2016.06.011 | ||
DB12867 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1016/j.bmc.2016.06.011 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
72901200 | 119272 | 21 | None | 154 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
CHEMBL3480577 | 119272 | 21 | None | 154 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
11090403 | 119039 | 0 | None | 2 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 389 | 6 | 1 | 4 | 3.4 | COc1cccc(C(=O)NCCN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL345848 | 119039 | 0 | None | 2 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 389 | 6 | 1 | 4 | 3.4 | COc1cccc(C(=O)NCCN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
9977532 | 110703 | 0 | None | 6 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL326454 | 110703 | 0 | None | 6 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
11574902 | 78041 | 0 | None | 537 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 400 | 4 | 0 | 5 | 3.4 | COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1 | 10.1016/j.ejmech.2019.111569 | ||
CHEMBL211164 | 78041 | 0 | None | 537 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 400 | 4 | 0 | 5 | 3.4 | COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1 | 10.1016/j.ejmech.2019.111569 | ||
155515982 | 169443 | 0 | None | 6 | 17 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4442460 | 169443 | 0 | None | 6 | 17 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
11574902 | 78041 | 0 | None | 537 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 400 | 4 | 0 | 5 | 3.4 | COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL211164 | 78041 | 0 | None | 537 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 400 | 4 | 0 | 5 | 3.4 | COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1 | 10.1021/jm060166w | ||
11036114 | 50250 | 0 | None | 134 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL157388 | 50250 | 0 | None | 134 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3)CC2)c1 | 10.1021/jm020952a | ||
17449900 | 139012 | 12 | None | 23 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 348 | 5 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL379602 | 139012 | 12 | None | 23 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 348 | 5 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
10733406 | 19241 | 0 | None | 70 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL129534 | 19241 | 0 | None | 70 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
10733406 | 19241 | 0 | None | 70 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1021/jm970422s | ||
CHEMBL129534 | 19241 | 0 | None | 70 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1021/jm970422s | ||
10546540 | 205507 | 0 | None | 288 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 361 | 4 | 1 | 4 | 4.7 | Cc1cccc(CN2CCC(n3c(O)nc(-c4ccccc4)c3C)CC2)c1 | 10.1021/jm991029k | ||
CHEMBL92859 | 205507 | 0 | None | 288 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 361 | 4 | 1 | 4 | 4.7 | Cc1cccc(CN2CCC(n3c(O)nc(-c4ccccc4)c3C)CC2)c1 | 10.1021/jm991029k | ||
11583188 | 138752 | 0 | None | 218 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 448 | 4 | 0 | 5 | 3.3 | COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1 | 10.1016/j.ejmech.2019.111569 | ||
CHEMBL379125 | 138752 | 0 | None | 218 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 448 | 4 | 0 | 5 | 3.3 | COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1 | 10.1016/j.ejmech.2019.111569 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm049612a | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm049612a | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm049612a | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm049612a | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/jm049612a | ||
11583188 | 138752 | 0 | None | 218 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 448 | 4 | 0 | 5 | 3.3 | COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL379125 | 138752 | 0 | None | 218 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 448 | 4 | 0 | 5 | 3.3 | COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1 | 10.1021/jm060166w | ||
5041 | 3242 | 5 | None | -1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 10.1021/acs.jmedchem.7b00151 | ||
981 | 3242 | 5 | None | -1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL4096543 | 3242 | 5 | None | -1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 10.1021/acs.jmedchem.7b00151 | ||
5041 | 3242 | 5 | None | -1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 10.1021/acs.jmedchem.8b00265 | ||
981 | 3242 | 5 | None | -1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4096543 | 3242 | 5 | None | -1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 10.1021/acs.jmedchem.8b00265 | ||
49788939 | 18075 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.5 | O=C(NCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)cc1 | 10.1021/jm100925m | ||
CHEMBL1270323 | 18075 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.5 | O=C(NCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)cc1 | 10.1021/jm100925m | ||
10780510 | 19297 | 0 | None | 208 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2)cc1C | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL129927 | 19297 | 0 | None | 208 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2)cc1C | 10.1016/j.bmcl.2005.02.012 | ||
10780510 | 19297 | 0 | None | 208 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2)cc1C | 10.1021/jm970422s | ||
CHEMBL129927 | 19297 | 0 | None | 208 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2)cc1C | 10.1021/jm970422s | ||
44400585 | 68313 | 0 | None | 26 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL191962 | 68313 | 0 | None | 26 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
21219157 | 98443 | 0 | None | 15 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1nn(C2CCN(Cc3ccccc3)CC2)cc1-c1ccccc1 | 10.1021/jm030836n | ||
CHEMBL279247 | 98443 | 0 | None | 15 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1nn(C2CCN(Cc3ccccc3)CC2)cc1-c1ccccc1 | 10.1021/jm030836n | ||
21219157 | 98443 | 0 | None | 15 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1nn(C2CCN(Cc3ccccc3)CC2)cc1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL279247 | 98443 | 0 | None | 15 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1nn(C2CCN(Cc3ccccc3)CC2)cc1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0305669 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0305669 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0305669 | ||
3716121 | 83667 | 14 | None | 70 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 332 | 4 | 0 | 3 | 4.1 | COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207643 | 83667 | 14 | None | 70 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 332 | 4 | 0 | 3 | 4.1 | COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
168287284 | 192333 | 0 | None | 316 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5198170 | 192333 | 0 | None | 316 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222300 | 192333 | 0 | None | 316 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2[N+](=O)[O-])CC1 | 10.1021/acs.jmedchem.2c00840 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(99)00025-6 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(99)00025-6 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmcl.2004.09.046 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmcl.2004.09.046 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm9600712 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm9600712 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm9600712 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0002432 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0002432 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0002432 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2008.12.054 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2008.12.054 | ||
3303 | 2213 | 41 | None | -1 | 15 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2014.04.026 | ||
5311200 | 2213 | 41 | None | -1 | 15 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL267014 | 2213 | 41 | None | -1 | 15 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2014.04.026 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00241-4 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00241-4 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm981041x | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm981041x | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm981041x | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.7b00151 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.7b00151 | ||
44412482 | 77797 | 0 | None | 79 | 4 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1 | 10.1021/jm0611152 | ||
CHEMBL210404 | 77797 | 0 | None | 79 | 4 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1 | 10.1021/jm0611152 | ||
44412482 | 77797 | 0 | None | 79 | 4 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL210404 | 77797 | 0 | None | 79 | 4 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.7b01248 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.7b01248 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.7b01248 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.7b01248 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.7b01248 | ||
44436598 | 148763 | 0 | None | 112 | 4 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 3.5 | C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL394473 | 148763 | 0 | None | 112 | 4 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 3.5 | C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.9b00412 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.9b00412 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.9b00412 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.9b00412 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1021/acs.jmedchem.9b00412 | ||
10660814 | 18684 | 2 | None | 134 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL128232 | 18684 | 2 | None | 134 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
10667579 | 205654 | 0 | None | 2818 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2cccc(Cl)c2)CC1 | 10.1021/jm991029k | ||
CHEMBL93832 | 205654 | 0 | None | 2818 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2cccc(Cl)c2)CC1 | 10.1021/jm991029k | ||
10660814 | 18684 | 2 | None | 134 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1021/jm970422s | ||
CHEMBL128232 | 18684 | 2 | None | 134 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1cccc(OCCNCCCOc2ccccc2)c1 | 10.1021/jm970422s | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
6603897 | 2216 | 19 | None | -5 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 418 | 3 | 1 | 3 | 3.5 | Ic1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm9600712 | ||
978 | 2216 | 19 | None | -5 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 418 | 3 | 1 | 3 | 3.5 | Ic1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm9600712 | ||
CHEMBL60518 | 2216 | 19 | None | -5 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 418 | 3 | 1 | 3 | 3.5 | Ic1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm9600712 | ||
168268758 | 192163 | 0 | None | 107 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5172201 | 192163 | 0 | None | 107 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221189 | 192163 | 0 | None | 107 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
10708280 | 18761 | 1 | None | 323 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL128647 | 18761 | 1 | None | 323 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
10450892 | 21671 | 0 | None | 7 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCNCCCOc2ccccc2)cc1Cl | 10.1021/jm970422s | ||
CHEMBL131997 | 21671 | 0 | None | 7 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCNCCCOc2ccccc2)cc1Cl | 10.1021/jm970422s | ||
9995904 | 31004 | 2 | None | 1047 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL140099 | 31004 | 2 | None | 1047 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
9995904 | 31004 | 2 | None | 1047 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1 | 10.1021/jm060166w | ||
CHEMBL140099 | 31004 | 2 | None | 1047 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1 | 10.1021/jm060166w | ||
44400674 | 124669 | 0 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL364516 | 124669 | 0 | None | -1 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
10708280 | 18761 | 1 | None | 323 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL128647 | 18761 | 1 | None | 323 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
10450892 | 21671 | 0 | None | 7 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCNCCCOc2ccccc2)cc1Cl | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL131997 | 21671 | 0 | None | 7 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCNCCCOc2ccccc2)cc1Cl | 10.1016/j.bmcl.2005.02.012 | ||
10315310 | 22681 | 0 | None | 58 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL132884 | 22681 | 0 | None | 58 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
10315310 | 22681 | 0 | None | 58 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL132884 | 22681 | 0 | None | 58 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
11655570 | 79316 | 0 | None | 173 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 462 | 4 | 0 | 5 | 3.6 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL211590 | 79316 | 0 | None | 173 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 462 | 4 | 0 | 5 | 3.6 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1 | 10.1021/jm060166w | ||
32224 | 205178 | 3 | None | 4 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 326 | 1 | 0 | 3 | 4.2 | CN1CCN(C2=Cc3ccccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL90882 | 205178 | 3 | None | 4 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 326 | 1 | 0 | 3 | 4.2 | CN1CCN(C2=Cc3ccccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm00004a016 | ||
32224 | 205178 | 3 | None | 4 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 326 | 1 | 0 | 3 | 4.2 | CN1CCN(C2=Cc3ccccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL90882 | 205178 | 3 | None | 4 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 326 | 1 | 0 | 3 | 4.2 | CN1CCN(C2=Cc3ccccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm00043a008 | ||
44326285 | 111054 | 0 | None | 2 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 359 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL327984 | 111054 | 0 | None | 2 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 359 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
9888765 | 189026 | 1 | None | 3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 427 | 7 | 1 | 5 | 5.1 | Nc1nc(-c2ccc(F)cc2)c([C@@H]2CCN(CCCC(=O)c3ccc(F)cc3)C2)s1 | 10.1016/j.bmc.2008.02.091 | ||
CHEMBL514848 | 189026 | 1 | None | 3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 427 | 7 | 1 | 5 | 5.1 | Nc1nc(-c2ccc(F)cc2)c([C@@H]2CCN(CCCC(=O)c3ccc(F)cc3)C2)s1 | 10.1016/j.bmc.2008.02.091 | ||
155552185 | 173489 | 0 | None | 2 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4544086 | 173489 | 0 | None | 2 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
155559617 | 174312 | 0 | None | 9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4563944 | 174312 | 0 | None | 9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
10522613 | 205230 | 0 | None | 389 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 361 | 5 | 1 | 4 | 4.4 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL91229 | 205230 | 0 | None | 389 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 361 | 5 | 1 | 4 | 4.4 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm991029k | ||
44419065 | 83906 | 0 | None | 56 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 4.3 | c1ccc(C2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL221600 | 83906 | 0 | None | 56 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 4.3 | c1ccc(C2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
11983282 | 138414 | 0 | None | 56 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 315 | 4 | 0 | 3 | 4.2 | C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL378455 | 138414 | 0 | None | 56 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 315 | 4 | 0 | 3 | 4.2 | C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
9950165 | 205221 | 0 | None | 93 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 347 | 4 | 1 | 4 | 4.4 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL91162 | 205221 | 0 | None | 93 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 347 | 4 | 1 | 4 | 4.4 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00692-1 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00692-1 | ||
44400519 | 132608 | 0 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL370297 | 132608 | 0 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
168268758 | 192163 | 0 | None | 107 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5172201 | 192163 | 0 | None | 107 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221189 | 192163 | 0 | None | 107 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
9977022 | 192289 | 0 | None | 131 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5189614 | 192289 | 0 | None | 131 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222031 | 192289 | 0 | None | 131 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0611152 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0611152 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm0611152 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2009.05.015 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/j.bmc.2009.05.015 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00814-9 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00814-9 | ||
10783358 | 39429 | 4 | None | 42 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 340 | 6 | 1 | 5 | 1.6 | COc1cccc(C(=O)NCCN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL147483 | 39429 | 4 | None | 42 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 340 | 6 | 1 | 5 | 1.6 | COc1cccc(C(=O)NCCN2CCN(c3ccccn3)CC2)c1 | 10.1021/jm020952a | ||
11676195 | 193478 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 3.4 | CSc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
CHEMBL550222 | 193478 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 3.4 | CSc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
44400626 | 70059 | 0 | None | 38 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL194555 | 70059 | 0 | None | 38 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
10547607 | 205218 | 0 | None | 1380 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 4.4 | COc1cccc(CN2CCC(n3c(O)nc(-c4ccccc4)c3C)CC2)c1 | 10.1021/jm991029k | ||
CHEMBL91155 | 205218 | 0 | None | 1380 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 4.4 | COc1cccc(CN2CCC(n3c(O)nc(-c4ccccc4)c3C)CC2)c1 | 10.1021/jm991029k | ||
168285556 | 192315 | 0 | None | 2454 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196870 | 192315 | 0 | None | 2454 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222200 | 192315 | 0 | None | 2454 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
11057969 | 33052 | 0 | None | 223 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm049612a | ||
CHEMBL141845 | 33052 | 0 | None | 223 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm049612a | ||
11057969 | 33052 | 0 | None | 223 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
CHEMBL141845 | 33052 | 0 | None | 223 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
10669042 | 107658 | 0 | None | -2 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 405 | 5 | 2 | 4 | 4.2 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(C3C4CCCC3CCC4)C2)cc1Cl | 10.1021/jm9601720 | ||
CHEMBL319597 | 107658 | 0 | None | -2 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 405 | 5 | 2 | 4 | 4.2 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(C3C4CCCC3CCC4)C2)cc1Cl | 10.1021/jm9601720 | ||
168268850 | 192182 | 0 | None | 741 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5179930 | 192182 | 0 | None | 741 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221350 | 192182 | 0 | None | 741 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
11057969 | 33052 | 0 | None | 223 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm0611152 | ||
CHEMBL141845 | 33052 | 0 | None | 223 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm0611152 | ||
25072633 | 158675 | 0 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 380 | 8 | 0 | 6 | 3.3 | COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4098803 | 158675 | 0 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 380 | 8 | 0 | 6 | 3.3 | COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
168268839 | 192179 | 0 | None | 30 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5177462 | 192179 | 0 | None | 30 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221334 | 192179 | 0 | None | 30 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
792584 | 91720 | 7 | None | 58 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 297 | 5 | 0 | 4 | 2.8 | CCOc1ccccc1N1CCN(Cc2cccnc2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420779 | 91720 | 7 | None | 58 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 297 | 5 | 0 | 4 | 2.8 | CCOc1ccccc1N1CCN(Cc2cccnc2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.9b01085 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.9b01085 | ||
41532205 | 77880 | 1 | None | 69 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL210717 | 77880 | 1 | None | 69 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
2653640 | 65887 | 12 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184486 | 65887 | 12 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1016/j.bmcl.2004.07.068 | ||
10450375 | 99031 | 0 | None | -1 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 347 | 5 | 0 | 4 | 3.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm981041x | ||
CHEMBL28321 | 99031 | 0 | None | -1 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 347 | 5 | 0 | 4 | 3.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm981041x | ||
41532205 | 77880 | 1 | None | 69 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1021/jm0611152 | ||
CHEMBL210717 | 77880 | 1 | None | 69 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1 | 10.1021/jm0611152 | ||
10643588 | 205690 | 0 | None | 239 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccc(Cl)cc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL94023 | 205690 | 0 | None | 239 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccc(Cl)cc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
71456045 | 83659 | 0 | None | 141 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207635 | 83659 | 0 | None | 141 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
49782398 | 17270 | 0 | None | 5 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 471 | 6 | 1 | 3 | 5.7 | O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
CHEMBL1257688 | 17270 | 0 | None | 5 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 471 | 6 | 1 | 3 | 5.7 | O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
122191607 | 123205 | 0 | None | 74 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 468 | 9 | 1 | 3 | 5.0 | CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1021/acsmedchemlett.5b00131 | ||
CHEMBL3622099 | 123205 | 0 | None | 74 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 468 | 9 | 1 | 3 | 5.0 | CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1021/acsmedchemlett.5b00131 | ||
25093832 | 155339 | 0 | None | -3 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4060461 | 155339 | 0 | None | -3 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm020952a | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm020952a | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm020952a | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm020952a | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm020952a | ||
10594764 | 111281 | 0 | None | 19 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 361 | 4 | 0 | 4 | 4.0 | Cc1c(-c2ccccc2)n(C)c(=O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL328739 | 111281 | 0 | None | 19 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 361 | 4 | 0 | 4 | 4.0 | Cc1c(-c2ccccc2)n(C)c(=O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
4452 | 2721 | 18 | None | -7 | 18 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1016/j.bmcl.2021.128047 | ||
983 | 2721 | 18 | None | -7 | 18 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL20734 | 2721 | 18 | None | -7 | 18 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1016/j.bmcl.2021.128047 | ||
44340097 | 9349 | 0 | None | 8 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL111749 | 9349 | 0 | None | 8 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
102505294 | 192397 | 0 | None | 309 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5204418 | 192397 | 0 | None | 309 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222691 | 192397 | 0 | None | 309 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
71454295 | 83665 | 0 | None | 30 | 7 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 536 | 8 | 0 | 6 | 5.5 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207641 | 83665 | 0 | None | 30 | 7 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 536 | 8 | 0 | 6 | 5.5 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
10638052 | 19892 | 0 | None | 70 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 301 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCNCCCSc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL130402 | 19892 | 0 | None | 70 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 301 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCNCCCSc2ccccc2)cc1 | 10.1021/jm970422s | ||
60165418 | 74999 | 0 | None | 8 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 353 | 6 | 0 | 6 | 3.2 | c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037521 | 74999 | 0 | None | 8 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 353 | 6 | 0 | 6 | 3.2 | c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.ejmech.2012.03.042 | ||
10734727 | 19262 | 0 | None | 117 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 323 | 9 | 1 | 3 | 3.9 | Fc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL129757 | 19262 | 0 | None | 117 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 323 | 9 | 1 | 3 | 3.9 | Fc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
9977532 | 110703 | 0 | None | 6 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL326454 | 110703 | 0 | None | 6 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
10783874 | 205318 | 0 | None | 13 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 347 | 4 | 0 | 4 | 3.7 | Cn1c(-c2ccccc2)cn(C2CCN(Cc3ccccc3)CC2)c1=O | 10.1021/jm991029k | ||
CHEMBL91669 | 205318 | 0 | None | 13 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 347 | 4 | 0 | 4 | 3.7 | Cn1c(-c2ccccc2)cn(C2CCN(Cc3ccccc3)CC2)c1=O | 10.1021/jm991029k | ||
10734727 | 19262 | 0 | None | 117 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 323 | 9 | 1 | 3 | 3.9 | Fc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1021/jm970422s | ||
CHEMBL129757 | 19262 | 0 | None | 117 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 323 | 9 | 1 | 3 | 3.9 | Fc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1021/jm970422s | ||
60165418 | 74999 | 0 | None | 8 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 353 | 6 | 0 | 6 | 3.2 | c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL2037521 | 74999 | 0 | None | 8 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 353 | 6 | 0 | 6 | 3.2 | c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
11697270 | 76957 | 0 | None | 44 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 412 | 5 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL208274 | 76957 | 0 | None | 44 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 412 | 5 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1 | 10.1021/jm060166w | ||
10522614 | 205289 | 0 | None | 30 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 361 | 5 | 1 | 4 | 4.7 | CCc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL91498 | 205289 | 0 | None | 30 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 361 | 5 | 1 | 4 | 4.7 | CCc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
4452 | 2721 | 18 | None | -7 | 18 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1016/j.bmc.2020.115578 | ||
983 | 2721 | 18 | None | -7 | 18 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1016/j.bmc.2020.115578 | ||
CHEMBL20734 | 2721 | 18 | None | -7 | 18 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 10.1016/j.bmc.2020.115578 | ||
168274496 | 192210 | 0 | None | 724 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5175054 | 192210 | 0 | None | 724 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221490 | 192210 | 0 | None | 724 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 417 | 5 | 0 | 3 | 4.5 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
12765116 | 204793 | 1 | None | 6 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 326 | 1 | 0 | 3 | 4.2 | CN1CCN(C2=Cc3cc(Cl)ccc3Oc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL88464 | 204793 | 1 | None | 6 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 326 | 1 | 0 | 3 | 4.2 | CN1CCN(C2=Cc3cc(Cl)ccc3Oc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm990277d | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm990277d | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/jm990277d | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00252-2 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(98)00252-2 | ||
44400553 | 70435 | 0 | None | 3 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL195083 | 70435 | 0 | None | 3 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
49788941 | 18090 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 353 | 5 | 1 | 5 | 1.6 | N#Cc1cccnc1N1CCN(CCNC(=O)c2ccc(F)cc2)CC1 | 10.1021/jm100925m | ||
CHEMBL1270423 | 18090 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 353 | 5 | 1 | 5 | 1.6 | N#Cc1cccnc1N1CCN(CCNC(=O)c2ccc(F)cc2)CC1 | 10.1021/jm100925m | ||
11689612 | 79429 | 0 | None | 436 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 388 | 5 | 0 | 7 | 2.9 | COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL212160 | 79429 | 0 | None | 436 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 388 | 5 | 0 | 7 | 2.9 | COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1 | 10.1021/jm060166w | ||
10247720 | 12943 | 0 | None | 2 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL1190042 | 12943 | 0 | None | 2 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL540039 | 12943 | 0 | None | 2 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
10447709 | 21086 | 1 | None | 245 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 303 | 9 | 1 | 3 | 3.6 | Cc1ccc(OCCNCCCOc2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL131357 | 21086 | 1 | None | 245 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 303 | 9 | 1 | 3 | 3.6 | Cc1ccc(OCCNCCCOc2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
76325150 | 105941 | 0 | None | 5 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115575 | 105941 | 0 | None | 5 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139554 | 105941 | 0 | None | 5 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | ||
10248715 | 167314 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 372 | 4 | 1 | 5 | 4.3 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2cccc(C#N)c2)CC1 | 10.1021/jm991029k | ||
CHEMBL431095 | 167314 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 372 | 4 | 1 | 5 | 4.3 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2cccc(C#N)c2)CC1 | 10.1021/jm991029k | ||
10447709 | 21086 | 1 | None | 245 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 303 | 9 | 1 | 3 | 3.6 | Cc1ccc(OCCNCCCOc2ccc(F)cc2)cc1 | 10.1021/jm970422s | ||
CHEMBL131357 | 21086 | 1 | None | 245 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 303 | 9 | 1 | 3 | 3.6 | Cc1ccc(OCCNCCCOc2ccc(F)cc2)cc1 | 10.1021/jm970422s | ||
76325150 | 105941 | 0 | None | 5 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115575 | 105941 | 0 | None | 5 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139554 | 105941 | 0 | None | 5 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | ||
10236758 | 115272 | 3 | None | 208 | 13 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL3354065 | 115272 | 3 | None | 208 | 13 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
168268756 | 192162 | 0 | None | 1737 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5171439 | 192162 | 0 | None | 1737 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221187 | 192162 | 0 | None | 1737 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
10236758 | 115272 | 3 | None | 208 | 13 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354065 | 115272 | 3 | None | 208 | 13 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 328 | 7 | 0 | 2 | 4.3 | CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
11516033 | 138588 | 5 | None | 1023 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 4.0 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl | 10.1016/j.ejmech.2019.111569 | ||
CHEMBL378680 | 138588 | 5 | None | 1023 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 4.0 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl | 10.1016/j.ejmech.2019.111569 | ||
122180954 | 121255 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 368 | 7 | 1 | 3 | 4.5 | CCCN(CCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3589575 | 121255 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 368 | 7 | 1 | 3 | 4.5 | CCCN(CCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
11575799 | 77775 | 0 | None | 1000 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 4.7 | Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl | 10.1021/jm060166w | ||
CHEMBL210341 | 77775 | 0 | None | 1000 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 4.7 | Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl | 10.1021/jm060166w | ||
11661609 | 79283 | 0 | None | 190 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 414 | 4 | 0 | 5 | 3.7 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL211539 | 79283 | 0 | None | 190 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 414 | 4 | 0 | 5 | 3.7 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1 | 10.1021/jm060166w | ||
9951735 | 203544 | 0 | None | 8 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 4.8 | Nc1nc(-c2ccc(Cl)cc2)cc(C2CCN(Cc3ccccc3)CC2)n1 | 10.1021/jm970111h | ||
CHEMBL78923 | 203544 | 0 | None | 8 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 4.8 | Nc1nc(-c2ccc(Cl)cc2)cc(C2CCN(Cc3ccccc3)CC2)n1 | 10.1021/jm970111h | ||
10594242 | 205021 | 0 | None | 7 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 353 | 4 | 1 | 5 | 4.5 | Cc1c(-c2cccs2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL90005 | 205021 | 0 | None | 7 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 353 | 4 | 1 | 5 | 4.5 | Cc1c(-c2cccs2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
13014692 | 203213 | 1 | None | -1 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 324 | 1 | 0 | 2 | 4.0 | CN1CCN(C2=Cc3ccccc3Cc3ccc(Cl)cc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL7617 | 203213 | 1 | None | -1 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 324 | 1 | 0 | 2 | 4.0 | CN1CCN(C2=Cc3ccccc3Cc3ccc(Cl)cc32)CC1 | 10.1021/jm00043a008 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960268u | ||
10314824 | 35153 | 1 | None | 8511 | 5 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL143761 | 35153 | 1 | None | 8511 | 5 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
44412182 | 76913 | 0 | None | 54 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL208018 | 76913 | 0 | None | 54 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
10403608 | 77798 | 6 | None | 50 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL210405 | 77798 | 6 | None | 50 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
44412182 | 76913 | 0 | None | 54 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1 | 10.1021/jm0611152 | ||
CHEMBL208018 | 76913 | 0 | None | 54 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1 | 10.1021/jm0611152 | ||
10403608 | 77798 | 6 | None | 50 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL210405 | 77798 | 6 | None | 50 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
10403608 | 77798 | 6 | None | 50 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
CHEMBL210405 | 77798 | 6 | None | 50 | 6 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
10314824 | 35153 | 1 | None | 8511 | 5 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1 | 10.1021/jm060166w | ||
CHEMBL143761 | 35153 | 1 | None | 8511 | 5 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1 | 10.1021/jm060166w | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991138z | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991138z | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991138z | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991138z | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm991138z | ||
102505294 | 192397 | 0 | None | 309 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5204418 | 192397 | 0 | None | 309 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222691 | 192397 | 0 | None | 309 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
168289100 | 192349 | 0 | None | 316 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 374 | 5 | 0 | 4 | 3.1 | N#Cc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5191299 | 192349 | 0 | None | 316 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 374 | 5 | 0 | 4 | 3.1 | N#Cc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222419 | 192349 | 0 | None | 316 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 374 | 5 | 0 | 4 | 3.1 | N#Cc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
10732925 | 114718 | 1 | None | 269 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2C)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL334545 | 114718 | 1 | None | 269 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2C)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
90644061 | 111541 | 0 | None | 177 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289646 | 111541 | 0 | None | 177 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
10666315 | 96141 | 0 | None | 47 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 361 | 4 | 1 | 4 | 4.7 | Cc1ccc(-c2nc(O)n(C3CCN(Cc4ccccc4)CC3)c2C)cc1 | 10.1021/jm991029k | ||
CHEMBL263162 | 96141 | 0 | None | 47 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 361 | 4 | 1 | 4 | 4.7 | Cc1ccc(-c2nc(O)n(C3CCN(Cc4ccccc4)CC3)c2C)cc1 | 10.1021/jm991029k | ||
10809899 | 205018 | 0 | None | 34 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2Cl)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL89971 | 205018 | 0 | None | 34 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2Cl)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
511482 | 96803 | 5 | None | 53 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 325 | 3 | 1 | 2 | 4.1 | Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL268799 | 96803 | 5 | None | 53 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 325 | 3 | 1 | 2 | 4.1 | Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
10570479 | 111782 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 359 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL329106 | 111782 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 359 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
10732925 | 114718 | 1 | None | 269 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2C)cc1 | 10.1021/jm970422s | ||
CHEMBL334545 | 114718 | 1 | None | 269 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2ccccc2C)cc1 | 10.1021/jm970422s | ||
10406796 | 99540 | 9 | None | -19 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL286725 | 99540 | 9 | None | -19 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
9805944 | 55934 | 31 | None | -1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm800510m | ||
CHEMBL1627 | 55934 | 31 | None | -1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm800510m | ||
90644061 | 111541 | 0 | None | 177 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289646 | 111541 | 0 | None | 177 | 5 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
9797495 | 68662 | 0 | None | 3548 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 328 | 3 | 0 | 4 | 2.9 | Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1 | 10.1021/jm200762g | ||
CHEMBL1923292 | 68662 | 0 | None | 3548 | 5 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 328 | 3 | 0 | 4 | 2.9 | Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1 | 10.1021/jm200762g | ||
44340227 | 110152 | 0 | None | 16 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 486 | 5 | 1 | 3 | 4.5 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL325772 | 110152 | 0 | None | 16 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 486 | 5 | 1 | 3 | 4.5 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10619737 | 200712 | 0 | None | 239 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 379 | 5 | 1 | 2 | 5.5 | Cc1c(C2CCN(CCc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm970111h | ||
CHEMBL61079 | 200712 | 0 | None | 239 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 379 | 5 | 1 | 2 | 5.5 | Cc1c(C2CCN(CCc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm970111h | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
10494394 | 167984 | 1 | None | 158 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2cccc(C)c2)cc1 | 10.1021/jm970422s | ||
CHEMBL435598 | 167984 | 1 | None | 158 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2cccc(C)c2)cc1 | 10.1021/jm970422s | ||
137651936 | 156850 | 0 | None | -1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4078348 | 156850 | 0 | None | -1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
21219176 | 95844 | 0 | None | 12 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 356 | 4 | 0 | 4 | 4.6 | Cc1nn(C2CCN(Cc3cccc(C#N)c3)CC2)cc1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL26120 | 95844 | 0 | None | 12 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 356 | 4 | 0 | 4 | 4.6 | Cc1nn(C2CCN(Cc3cccc(C#N)c3)CC2)cc1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
10619737 | 200712 | 0 | None | 239 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 379 | 5 | 1 | 2 | 5.5 | Cc1c(C2CCN(CCc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm960072u | ||
CHEMBL61079 | 200712 | 0 | None | 239 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 379 | 5 | 1 | 2 | 5.5 | Cc1c(C2CCN(CCc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm960072u | ||
45273045 | 194702 | 0 | None | 199 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
CHEMBL562620 | 194702 | 0 | None | 199 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
10427977 | 54180 | 0 | None | 660 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.3 | C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160952 | 54180 | 0 | None | 660 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.3 | C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
10494394 | 167984 | 1 | None | 158 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2cccc(C)c2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL435598 | 167984 | 1 | None | 158 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCNCCCOc2cccc(C)c2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
10088259 | 101443 | 3 | None | 134 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL300956 | 101443 | 3 | None | 134 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
10427977 | 54180 | 0 | None | 660 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.3 | C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1021/jm0611152 | ||
CHEMBL160952 | 54180 | 0 | None | 660 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 350 | 3 | 0 | 4 | 3.3 | C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1021/jm0611152 | ||
137640201 | 156419 | 2 | None | 177 | 13 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 362 | 6 | 0 | 2 | 4.3 | O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4072818 | 156419 | 2 | None | 177 | 13 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 362 | 6 | 0 | 2 | 4.3 | O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
9905249 | 99440 | 0 | None | 2 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL28607 | 99440 | 0 | None | 2 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
10762432 | 205680 | 0 | None | 46 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1021/jm991029k | ||
CHEMBL93969 | 205680 | 0 | None | 46 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1021/jm991029k | ||
10740483 | 205402 | 0 | None | 3 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 413 | 7 | 2 | 4 | 3.5 | C=CC(=O)Nc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1021/jm9601720 | ||
CHEMBL92192 | 205402 | 0 | None | 3 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 413 | 7 | 2 | 4 | 3.5 | C=CC(=O)Nc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1021/jm9601720 | ||
44454709 | 97069 | 0 | None | 72 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 404 | 9 | 0 | 6 | 3.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL270406 | 97069 | 0 | None | 72 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 404 | 9 | 0 | 6 | 3.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC | 10.1016/j.bmcl.2007.12.026 | ||
10450375 | 99031 | 0 | None | -1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 347 | 5 | 0 | 4 | 3.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
CHEMBL28321 | 99031 | 0 | None | -1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 347 | 5 | 0 | 4 | 3.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
16094698 | 137343 | 4 | None | 20 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 338 | 5 | 1 | 3 | 3.6 | COc1ccccc1C1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm060662k | ||
CHEMBL376092 | 137343 | 4 | None | 20 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 338 | 5 | 1 | 3 | 3.6 | COc1ccccc1C1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm060662k | ||
25256816 | 181026 | 0 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 407 | 7 | 0 | 4 | 3.7 | COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL477206 | 181026 | 0 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 407 | 7 | 0 | 4 | 3.7 | COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
10450375 | 99031 | 0 | None | -1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 347 | 5 | 0 | 4 | 3.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL28321 | 99031 | 0 | None | -1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 347 | 5 | 0 | 4 | 3.8 | COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
10406796 | 99540 | 9 | None | -19 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL286725 | 99540 | 9 | None | -19 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/S0960-894X(97)00218-7 | ||
25072002 | 155573 | 0 | None | -6 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 405 | 8 | 0 | 7 | 3.2 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4063235 | 155573 | 0 | None | -6 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 405 | 8 | 0 | 7 | 3.2 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
11696910 | 77394 | 0 | None | 281 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 4.0 | Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1 | 10.1021/jm060166w | ||
CHEMBL209034 | 77394 | 0 | None | 281 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 4.0 | Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1 | 10.1021/jm060166w | ||
11631892 | 77757 | 0 | None | 2630 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 361 | 4 | 0 | 6 | 2.8 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL210283 | 77757 | 0 | None | 2630 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 361 | 4 | 0 | 6 | 2.8 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1 | 10.1021/jm060166w | ||
10359942 | 102463 | 4 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1ccc(CN2CC=C(c3nc4ccccc4s3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL306265 | 102463 | 4 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1ccc(CN2CC=C(c3nc4ccccc4s3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
168294165 | 192410 | 0 | None | 204 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5209074 | 192410 | 0 | None | 204 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222773 | 192410 | 0 | None | 204 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1ccccc1N1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
137645938 | 157041 | 0 | None | 204 | 8 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 342 | 8 | 0 | 2 | 4.6 | CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4080675 | 157041 | 0 | None | 204 | 8 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 342 | 8 | 0 | 2 | 4.6 | CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
9863333 | 202662 | 0 | None | 1 | 10 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
CHEMBL71724 | 202662 | 0 | None | 1 | 10 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmc.2016.06.011 | ||
10615787 | 116263 | 0 | None | 67 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 321 | 9 | 1 | 3 | 4.5 | Clc1ccc(OCCNCCCSc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL337627 | 116263 | 0 | None | 67 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 321 | 9 | 1 | 3 | 4.5 | Clc1ccc(OCCNCCCSc2ccccc2)cc1 | 10.1021/jm970422s | ||
16094666 | 81315 | 2 | None | 52 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL216393 | 81315 | 2 | None | 52 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10498094 | 32102 | 1 | None | 1047 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL141035 | 32102 | 1 | None | 1047 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1 | 10.1021/jm0009989 | ||
122181333 | 121360 | 0 | None | 10 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 366 | 8 | 1 | 2 | 3.8 | CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590084 | 121360 | 0 | None | 10 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 366 | 8 | 1 | 2 | 3.8 | CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
11516033 | 138588 | 5 | None | 1023 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 4.0 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl | 10.1021/jm060166w | ||
CHEMBL378680 | 138588 | 5 | None | 1023 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 4.0 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl | 10.1021/jm060166w | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
10314060 | 168035 | 0 | None | 72 | 7 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL435949 | 168035 | 0 | None | 72 | 7 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/s0960-894x(01)00241-4 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c00611 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c00611 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c00611 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c00611 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c00611 | ||
168285556 | 192315 | 0 | None | 2454 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196870 | 192315 | 0 | None | 2454 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222200 | 192315 | 0 | None | 2454 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.8 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
9883587 | 111067 | 0 | None | 39 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 321 | 3 | 0 | 4 | 3.4 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
CHEMBL328054 | 111067 | 0 | None | 39 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 321 | 3 | 0 | 4 | 3.4 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
44394743 | 122585 | 0 | None | 39 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL361035 | 122585 | 0 | None | 39 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
10595908 | 203547 | 0 | None | 22 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 379 | 5 | 1 | 2 | 5.7 | CCc1c(C2CCN(Cc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm970111h | ||
CHEMBL78933 | 203547 | 0 | None | 22 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 379 | 5 | 1 | 2 | 5.7 | CCc1c(C2CCN(Cc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm970111h | ||
10716772 | 205555 | 0 | None | 3 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 415 | 7 | 2 | 4 | 3.7 | CCC(=O)Nc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1021/jm9601720 | ||
CHEMBL93198 | 205555 | 0 | None | 3 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 415 | 7 | 2 | 4 | 3.7 | CCC(=O)Nc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1021/jm9601720 | ||
12765746 | 101810 | 3 | None | -14 | 10 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm020938y | ||
CHEMBL303313 | 101810 | 3 | None | -14 | 10 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm020938y | ||
57403525 | 69811 | 0 | None | 6 | 10 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2011.12.019 | ||
57403525 | 69811 | 0 | None | 6 | 10 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL1940402 | 69811 | 0 | None | 6 | 10 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940402 | 69811 | 0 | None | 6 | 10 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
44394743 | 122585 | 0 | None | 39 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL361035 | 122585 | 0 | None | 39 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
25093832 | 155339 | 0 | None | -3 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4060461 | 155339 | 0 | None | -3 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
137660837 | 158534 | 0 | None | -2 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4097330 | 158534 | 0 | None | -2 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
71456046 | 83661 | 0 | None | 114 | 7 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 4.2 | COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207637 | 83661 | 0 | None | 114 | 7 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 4.2 | COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
44381216 | 119826 | 0 | None | 8511 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL352925 | 119826 | 0 | None | 8511 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
44371997 | 49660 | 0 | None | 10000 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 3 | 0 | 4 | 3.6 | C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL156851 | 49660 | 0 | None | 10000 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 3 | 0 | 4 | 3.6 | C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12 | 10.1016/s0960-894x(01)00814-9 | ||
11725531 | 53769 | 1 | None | 1445 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 0 | 5 | 3.2 | N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160626 | 53769 | 1 | None | 1445 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 0 | 5 | 3.2 | N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
11301655 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/jm030505a | ||
8441 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/jm030505a | ||
CHEMBL127257 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/jm030505a | ||
11301655 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
8441 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL127257 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
49788869 | 18040 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 365 | 6 | 1 | 6 | 1.5 | COc1cccc(C(=O)NCCN2CCN(c3ncccc3C#N)CC2)c1 | 10.1021/jm100925m | ||
CHEMBL1270121 | 18040 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 365 | 6 | 1 | 6 | 1.5 | COc1cccc(C(=O)NCCN2CCN(c3ncccc3C#N)CC2)c1 | 10.1021/jm100925m | ||
127049060 | 140244 | 0 | None | 13 | 7 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 2 | 3 | 3.9 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1c[nH]c3ccccc13)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818478 | 140244 | 0 | None | 13 | 7 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 2 | 3 | 3.9 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1c[nH]c3ccccc13)CC2 | 10.1016/j.bmc.2016.06.011 | ||
76321554 | 105922 | 0 | None | 5 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115574 | 105922 | 0 | None | 5 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139450 | 105922 | 0 | None | 5 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | ||
9954003 | 71356 | 18 | None | -3 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 422 | 5 | 2 | 4 | 3.8 | C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O | 10.1021/jm070516u | ||
CHEMBL196514 | 71356 | 18 | None | -3 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 422 | 5 | 2 | 4 | 3.8 | C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O | 10.1021/jm070516u | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(01)00200-1 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(01)00200-1 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(01)00200-1 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(01)00200-1 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(01)00200-1 | ||
76321554 | 105922 | 0 | None | 5 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115574 | 105922 | 0 | None | 5 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139450 | 105922 | 0 | None | 5 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | ||
44340084 | 9000 | 0 | None | 6 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 401 | 6 | 2 | 4 | 4.0 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL109912 | 9000 | 0 | None | 6 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 401 | 6 | 2 | 4 | 4.0 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
10618875 | 103745 | 0 | None | 125 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 365 | 4 | 1 | 2 | 5.4 | Cc1c(C2CCN(Cc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm970111h | ||
CHEMBL309901 | 103745 | 0 | None | 125 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 365 | 4 | 1 | 2 | 5.4 | Cc1c(C2CCN(Cc3ccccc3)CC2)n[nH]c1-c1ccc(Cl)cc1 | 10.1021/jm970111h | ||
9104271 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL69584 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
44454711 | 97070 | 0 | None | 36 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 344 | 7 | 0 | 4 | 3.4 | COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1 | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL270408 | 97070 | 0 | None | 36 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 344 | 7 | 0 | 4 | 3.4 | COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1 | 10.1016/j.bmcl.2007.12.026 | ||
511482 | 96803 | 5 | None | 53 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 325 | 3 | 1 | 2 | 4.1 | Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm9600712 | ||
CHEMBL268799 | 96803 | 5 | None | 53 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 325 | 3 | 1 | 2 | 4.1 | Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm9600712 | ||
9104271 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL69584 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
9104271 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL69584 | 202299 | 10 | None | 436 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(02)01056-9 | ||
10336039 | 118730 | 1 | None | 15 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(-n2ccc(CN3CCN(c4ccccn4)CC3)c2)cc1 | 10.1021/jm00025a013 | ||
CHEMBL343466 | 118730 | 1 | None | 15 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(-n2ccc(CN3CCN(c4ccccn4)CC3)c2)cc1 | 10.1021/jm00025a013 | ||
127049060 | 140244 | 0 | None | 13 | 7 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 2 | 3 | 3.9 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1c[nH]c3ccccc13)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818478 | 140244 | 0 | None | 13 | 7 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 2 | 3 | 3.9 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1c[nH]c3ccccc13)CC2 | 10.1016/j.bmc.2016.06.011 | ||
11682812 | 77835 | 0 | None | 239 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 5 | 0 | 7 | 3.2 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL210551 | 77835 | 0 | None | 239 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 5 | 0 | 7 | 3.2 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1 | 10.1021/jm060166w | ||
11581237 | 138429 | 0 | None | 15 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 357 | 4 | 0 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL378515 | 138429 | 0 | None | 15 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 357 | 4 | 0 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1 | 10.1021/jm060166w | ||
44376876 | 119667 | 0 | None | 27 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 3.7 | c1ccc(OC[C@@H]2CC[C@H]3CN(c4ccccc4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL351611 | 119667 | 0 | None | 27 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 3.7 | c1ccc(OC[C@@H]2CC[C@H]3CN(c4ccccc4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
155536720 | 171621 | 0 | None | 77 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473652 | 171621 | 0 | None | 77 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10690200 | 205400 | 0 | None | 169 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 365 | 4 | 1 | 4 | 4.5 | Cc1c(-c2ccc(F)cc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL92189 | 205400 | 0 | None | 169 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 365 | 4 | 1 | 4 | 4.5 | Cc1c(-c2ccc(F)cc2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
44323978 | 104804 | 0 | None | 11 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 325 | 3 | 1 | 2 | 4.1 | Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL311539 | 104804 | 0 | None | 11 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 325 | 3 | 1 | 2 | 4.1 | Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(98)00474-0 | ||
76316875 | 85460 | 0 | None | 18 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 321 | 3 | 1 | 0 | 3.4 | Clc1ccc2[nH]ccc2c1-[n+]1cc[n+](Cc2ccccc2)cc1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL2298810 | 85460 | 0 | None | 18 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 321 | 3 | 1 | 0 | 3.4 | Clc1ccc2[nH]ccc2c1-[n+]1cc[n+](Cc2ccccc2)cc1 | 10.1007/s00044-012-0055-5 | ||
24882561 | 94897 | 0 | None | 58 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 4.0 | COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL256637 | 94897 | 0 | None | 58 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 4.0 | COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC | 10.1016/j.bmcl.2007.12.026 | ||
155527714 | 170730 | 0 | None | 16 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 503 | 11 | 2 | 6 | 4.1 | COc1ccc(N(Cc2ccccc2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4460743 | 170730 | 0 | None | 16 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 503 | 11 | 2 | 6 | 4.1 | COc1ccc(N(Cc2ccccc2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
11726532 | 96578 | 0 | None | -2 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 368 | 8 | 0 | 5 | 3.5 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL26677 | 96578 | 0 | None | -2 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 368 | 8 | 0 | 5 | 3.5 | COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/S0960-894X(97)00218-7 | ||
44376569 | 57140 | 0 | None | 19 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OC[C@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL165504 | 57140 | 0 | None | 19 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OC[C@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
44376918 | 119507 | 0 | None | 109 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 323 | 4 | 0 | 4 | 3.1 | c1ccc(OC[C@@H]2CC[C@H]3CN(c4ccccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL350160 | 119507 | 0 | None | 109 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 323 | 4 | 0 | 4 | 3.1 | c1ccc(OC[C@@H]2CC[C@H]3CN(c4ccccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
42266988 | 18061 | 2 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 5 | 1 | 3 | 3.0 | O=C(NCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm100925m | ||
CHEMBL1270227 | 18061 | 2 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 5 | 1 | 3 | 3.0 | O=C(NCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm100925m | ||
168268695 | 192172 | 0 | None | 446 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1cccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5170580 | 192172 | 0 | None | 446 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1cccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221253 | 192172 | 0 | None | 446 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 363 | 5 | 0 | 3 | 3.5 | Cc1cccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.2c00840 | ||
21462964 | 47921 | 0 | None | 602 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.4 | c1ccc(CCC2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL155207 | 47921 | 0 | None | 602 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.4 | c1ccc(CCC2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
11792163 | 41831 | 0 | None | 316 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | Cc1ccc(C2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1C | 10.1021/jm990277d | ||
CHEMBL149596 | 41831 | 0 | None | 316 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | Cc1ccc(C2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1C | 10.1021/jm990277d | ||
44454735 | 94873 | 0 | None | 169 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 3.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL256492 | 94873 | 0 | None | 169 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 3.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF | 10.1016/j.bmcl.2007.12.026 | ||
10643697 | 120610 | 1 | None | 10 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.6 | COc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL357448 | 120610 | 1 | None | 10 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 383 | 8 | 1 | 5 | 2.6 | COc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
44209472 | 69829 | 2 | None | 1 | 11 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940420 | 69829 | 2 | None | 1 | 11 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
44209472 | 69829 | 2 | None | 1 | 11 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940420 | 69829 | 2 | None | 1 | 11 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0503805 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0503805 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0503805 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
2653640 | 65887 | 12 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184486 | 65887 | 12 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CC(=O)Nc2cccc(C)c2)CC1 | 10.1016/j.bmcl.2004.07.068 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(03)00004-0 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(03)00004-0 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
4797946 | 169856 | 8 | None | 165 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4448320 | 169856 | 8 | None | 165 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10837488 | 112155 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 6 | 2 | 4 | 3.9 | COc1cc(NC(=O)C(F)(F)F)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL330318 | 112155 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 6 | 2 | 4 | 3.9 | COc1cc(NC(=O)C(F)(F)F)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
22065971 | 120584 | 1 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1021/jm0002432 | ||
CHEMBL357182 | 120584 | 1 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1021/jm0002432 | ||
25256814 | 181030 | 0 | None | 1 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 7 | 0 | 4 | 3.3 | COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL477250 | 181030 | 0 | None | 1 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 7 | 0 | 4 | 3.3 | COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
71457844 | 83662 | 0 | None | 22 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207638 | 83662 | 0 | None | 22 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2004.07.068 | ||
56652776 | 192406 | 0 | None | 257 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.9 | c1ccc(N2CCN(CCCn3ccc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5205590 | 192406 | 0 | None | 257 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.9 | c1ccc(N2CCN(CCCn3ccc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222747 | 192406 | 0 | None | 257 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.9 | c1ccc(N2CCN(CCCn3ccc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
49788867 | 18022 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.4 | COc1cccc(C(=O)NCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm100925m | ||
CHEMBL1270013 | 18022 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.4 | COc1cccc(C(=O)NCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm100925m | ||
137642607 | 157972 | 0 | None | 234 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 348 | 5 | 0 | 2 | 4.2 | O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4091231 | 157972 | 0 | None | 234 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 348 | 5 | 0 | 2 | 4.2 | O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
10588194 | 18732 | 3 | None | 67 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 271 | 9 | 1 | 3 | 3.1 | c1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL128524 | 18732 | 3 | None | 67 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 271 | 9 | 1 | 3 | 3.1 | c1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
44336061 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL320597 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1021/acs.jmedchem.8b00265 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970111h | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970111h | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970111h | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970111h | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970111h | ||
10520941 | 203402 | 0 | None | 6 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 337 | 5 | 1 | 2 | 4.9 | c1ccc(CCN2CCC(c3cc(C4CCCCC4)n[nH]3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL77744 | 203402 | 0 | None | 6 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 337 | 5 | 1 | 2 | 4.9 | c1ccc(CCN2CCC(c3cc(C4CCCCC4)n[nH]3)CC2)cc1 | 10.1021/jm970111h | ||
9948584 | 205647 | 0 | None | -10 | 4 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 309 | 4 | 3 | 4 | 2.8 | Oc1nc2c3c(ccc2[nH]1)CCC(CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL93779 | 205647 | 0 | None | -10 | 4 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 309 | 4 | 3 | 4 | 2.8 | Oc1nc2c3c(ccc2[nH]1)CCC(CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
44273720 | 74845 | 0 | None | 100 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 391 | 7 | 1 | 3 | 4.3 | CC1(C(=O)NCCCCN2CCN(c3ccc(Cl)cc3)CC2)CCCCC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20367 | 74845 | 0 | None | 100 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 391 | 7 | 1 | 3 | 4.3 | CC1(C(=O)NCCCCN2CCN(c3ccc(Cl)cc3)CC2)CCCCC1 | 10.1016/0960-894X(96)00198-9 | ||
9801098 | 5329 | 0 | None | 301 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 399 | 5 | 1 | 4 | 2.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2C[C@H]1CO | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL107151 | 5329 | 0 | None | 301 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 399 | 5 | 1 | 4 | 2.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2C[C@H]1CO | 10.1016/s0960-894x(02)00656-x | ||
44335908 | 5912 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 425 | 5 | 0 | 3 | 4.6 | CC(C)c1ccc(Cl)cc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL108011 | 5912 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 425 | 5 | 0 | 3 | 4.6 | CC(C)c1ccc(Cl)cc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9600712 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9600712 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9600712 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9600712 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9600712 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960268u | ||
44336075 | 4840 | 0 | None | 15 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 378 | 5 | 0 | 3 | 4.3 | COc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104579 | 4840 | 0 | None | 15 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 378 | 5 | 0 | 3 | 4.3 | COc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
9948546 | 16148 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 308 | 6 | 2 | 4 | 3.3 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1 | 10.1021/jm990266k | ||
CHEMBL122754 | 16148 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 308 | 6 | 2 | 4 | 3.3 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1 | 10.1021/jm990266k | ||
44374827 | 118992 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 389 | 3 | 0 | 3 | 3.4 | Cc1ccc(CN2CCN(C3CCc4cccc5c4N(C3=O)C(C)C5)CC2)cc1 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL345438 | 118992 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 389 | 3 | 0 | 3 | 3.4 | Cc1ccc(CN2CCN(C3CCc4cccc5c4N(C3=O)C(C)C5)CC2)cc1 | 10.1016/s0960-894x(02)01056-9 | ||
164627977 | 185851 | 0 | None | -1 | 7 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4876297 | 185851 | 0 | None | -1 | 7 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
1353 | 1880 | 85 | None | -4 | 85 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
3559 | 1880 | 85 | None | -4 | 85 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
86 | 1880 | 85 | None | -4 | 85 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL54 | 1880 | 85 | None | -4 | 85 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
DB00502 | 1880 | 85 | None | -4 | 85 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
52940985 | 17404 | 0 | None | 17 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 369 | 6 | 0 | 2 | 5.8 | Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1258155 | 17404 | 0 | None | 17 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 369 | 6 | 0 | 2 | 5.8 | Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm100899z | ||
137651322 | 156933 | 0 | None | -11 | 6 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 465 | 8 | 2 | 9 | 2.2 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4079375 | 156933 | 0 | None | -11 | 6 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 465 | 8 | 2 | 9 | 2.2 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00169-9 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960072u | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00169-9 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960072u | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00169-9 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960072u | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960072u | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00169-9 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960072u | ||
122180956 | 121257 | 0 | None | 8 | 6 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 4.8 | CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3589577 | 121257 | 0 | None | 8 | 6 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 4.8 | CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
9887537 | 83927 | 38 | None | -12 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 405 | 4 | 0 | 5 | 4.0 | Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1 | 10.1021/jm070516u | ||
CHEMBL221692 | 83927 | 38 | None | -12 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 405 | 4 | 0 | 5 | 4.0 | Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1 | 10.1021/jm070516u | ||
CHEMBL4751170 | 83927 | 38 | None | -12 | 9 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 405 | 4 | 0 | 5 | 4.0 | Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1 | 10.1021/jm070516u | ||
11725909 | 202565 | 0 | None | 33 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 357 | 3 | 1 | 2 | 5.2 | Clc1ccc(CN2CC=C(c3nc4cc(Cl)ccc4[nH]3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL71216 | 202565 | 0 | None | 33 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 357 | 3 | 1 | 2 | 5.2 | Clc1ccc(CN2CC=C(c3nc4cc(Cl)ccc4[nH]3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
9907461 | 133719 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 371 | 4 | 1 | 3 | 3.8 | O=C1NC(CCN2CCN(c3ccc4ccccc4c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL37169 | 133719 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 371 | 4 | 1 | 3 | 3.8 | O=C1NC(CCN2CCN(c3ccc4ccccc4c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00252-2 | ||
9903877 | 198642 | 1 | None | -6 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 282 | 6 | 2 | 3 | 2.4 | O=C1Cc2c(cccc2OCCNCc2ccccc2)N1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL59752 | 198642 | 1 | None | -6 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 282 | 6 | 2 | 3 | 2.4 | O=C1Cc2c(cccc2OCCNCc2ccccc2)N1 | 10.1016/s0960-894x(99)00434-5 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991029k | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991029k | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991029k | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991029k | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991029k | ||
127029388 | 138809 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1cc(CN2CCO[C@H](COc3cccc(F)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792803 | 138809 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1cc(CN2CCO[C@H](COc3cccc(F)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
164938016 | 192367 | 0 | None | 67 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 4.1 | c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5200816 | 192367 | 0 | None | 67 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 4.1 | c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222506 | 192367 | 0 | None | 67 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 4.1 | c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
164627977 | 185851 | 0 | None | -1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4876297 | 185851 | 0 | None | -1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
127031516 | 138779 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792438 | 138779 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
92988697 | 138937 | 1 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794199 | 138937 | 1 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2003.07.015 | ||
9902382 | 42480 | 1 | None | 19 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 3 | 1 | 4 | 2.6 | Cc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL150173 | 42480 | 1 | None | 19 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 3 | 1 | 4 | 2.6 | Cc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
127029387 | 138877 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793612 | 138877 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
10590285 | 19854 | 1 | None | 21 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCCNCCOc2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL130370 | 19854 | 1 | None | 21 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCCNCCOc2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
12997400 | 100535 | 7 | None | 5 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 241 | 3 | 1 | 2 | 2.3 | c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL294394 | 100535 | 7 | None | 5 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 241 | 3 | 1 | 2 | 2.3 | c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
11726130 | 56182 | 0 | None | 4 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 361 | 1 | 0 | 1 | 6.3 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2cc(Cl)ccc21 | 10.1021/jm00004a016 | ||
CHEMBL163239 | 56182 | 0 | None | 4 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 361 | 1 | 0 | 1 | 6.3 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2cc(Cl)ccc21 | 10.1021/jm00004a016 | ||
44273884 | 76705 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 3.4 | CC(C)(C)C(=O)NCCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20729 | 76705 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 3.4 | CC(C)(C)C(=O)NCCCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
9820048 | 201948 | 0 | None | 13 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 355 | 3 | 1 | 3 | 3.0 | O=C1Nc2ccccc2CC1N1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL67222 | 201948 | 0 | None | 13 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 355 | 3 | 1 | 3 | 3.0 | O=C1Nc2ccccc2CC1N1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(00)00421-2 | ||
10811059 | 203902 | 4 | None | 23 | 4 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(N2CCN(CC[C@H]3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
CHEMBL81649 | 203902 | 4 | None | 23 | 4 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(N2CCN(CC[C@H]3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
44403219 | 71560 | 0 | None | -91 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 424 | 7 | 1 | 4 | 3.9 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL197162 | 71560 | 0 | None | -91 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 424 | 7 | 1 | 4 | 3.9 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1 | 10.1016/j.bmcl.2005.07.037 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
72205043 | 91512 | 0 | None | 1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 396 | 7 | 0 | 5 | 3.9 | Clc1ccc(-n2cc(COCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL2414354 | 91512 | 0 | None | 1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 396 | 7 | 0 | 5 | 3.9 | Clc1ccc(-n2cc(COCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
118719927 | 115281 | 0 | None | 2 | 8 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 386 | 11 | 1 | 3 | 4.4 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354074 | 115281 | 0 | None | 2 | 8 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 386 | 11 | 1 | 3 | 4.4 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
60165681 | 75006 | 0 | None | -3 | 6 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 413 | 7 | 0 | 5 | 5.1 | O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037528 | 75006 | 0 | None | -3 | 6 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 413 | 7 | 0 | 5 | 5.1 | O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
25139335 | 183736 | 0 | None | 2 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 314 | 8 | 0 | 4 | 3.6 | CC#CC1=CCC(N(CCC)CCCCn2cc(C)nn2)CC1 | 10.1021/jm800895v | ||
CHEMBL484203 | 183736 | 0 | None | 2 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 314 | 8 | 0 | 4 | 3.6 | CC#CC1=CCC(N(CCC)CCCCn2cc(C)nn2)CC1 | 10.1021/jm800895v | ||
57402366 | 68973 | 0 | None | -199 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 1033 | 32 | 2 | 17 | 5.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928139 | 68973 | 0 | None | -199 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 1033 | 32 | 2 | 17 | 5.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
72545239 | 92696 | 0 | None | 1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 499 | 14 | 0 | 9 | 3.0 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443006 | 92696 | 0 | None | 1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 499 | 14 | 0 | 9 | 3.0 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
44436621 | 90600 | 0 | None | -17 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 443 | 8 | 1 | 3 | 4.7 | C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL239733 | 90600 | 0 | None | -17 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 443 | 8 | 1 | 3 | 4.7 | C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
11245414 | 5050 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 362 | 6 | 1 | 5 | 3.2 | COc1ccc(N)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL105661 | 5050 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 362 | 6 | 1 | 5 | 3.2 | COc1ccc(N)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
154703647 | 175791 | 1 | None | -1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4450429 | 175791 | 1 | None | -1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595728 | 175791 | 1 | None | -1 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
13014683 | 96894 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 323 | 1 | 0 | 1 | 5.5 | CC1CCN(C2=Cc3cc(Cl)ccc3Cc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL269396 | 96894 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 323 | 1 | 0 | 1 | 5.5 | CC1CCN(C2=Cc3cc(Cl)ccc3Cc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
1687 | 103930 | 15 | None | -275 | 5 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 341 | 4 | 0 | 2 | 5.1 | CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2 | 10.1021/jm010146o | ||
CHEMBL310310 | 103930 | 15 | None | -275 | 5 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 341 | 4 | 0 | 2 | 5.1 | CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2 | 10.1021/jm010146o | ||
CHEMBL540034 | 103930 | 15 | None | -275 | 5 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 341 | 4 | 0 | 2 | 5.1 | CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2 | 10.1021/jm010146o | ||
242 | 467 | 117 | None | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
34 | 467 | 117 | None | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
33630 | 178379 | 94 | None | -13 | 27 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL47050 | 178379 | 94 | None | -13 | 27 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
127046951 | 139372 | 0 | None | -21 | 6 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 437 | 12 | 4 | 6 | 4.0 | COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3799427 | 139372 | 0 | None | -21 | 6 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 437 | 12 | 4 | 6 | 4.0 | COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
11360927 | 4902 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 377 | 7 | 0 | 5 | 3.6 | COc1cccc(OCC2CN(Cc3ccc(Cl)cc3)CCO2)c1OC | 10.1021/jm031111m | ||
CHEMBL104844 | 4902 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 377 | 7 | 0 | 5 | 3.6 | COc1cccc(OCC2CN(Cc3ccc(Cl)cc3)CCO2)c1OC | 10.1021/jm031111m | ||
145980271 | 165939 | 0 | None | -19 | 16 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 538 | 8 | 1 | 3 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL4278465 | 165939 | 0 | None | -19 | 16 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 538 | 8 | 1 | 3 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
46216855 | 198694 | 0 | None | -11220 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 395 | 1 | 1 | 3 | 5.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL597900 | 198694 | 0 | None | -11220 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 395 | 1 | 1 | 3 | 5.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
46231994 | 198724 | 0 | None | -16595 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 414 | 1 | 1 | 3 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL598105 | 198724 | 0 | None | -16595 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 414 | 1 | 1 | 3 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
46231848 | 198854 | 0 | None | -3235 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 396 | 1 | 1 | 3 | 4.1 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL598949 | 198854 | 0 | None | -3235 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 396 | 1 | 1 | 3 | 4.1 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
46231845 | 199049 | 0 | None | -3311 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 391 | 0 | 1 | 2 | 4.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL600083 | 199049 | 0 | None | -3311 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 391 | 0 | 1 | 2 | 4.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
46232066 | 199571 | 0 | None | -14125 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 419 | 2 | 1 | 3 | 5.7 | COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL603872 | 199571 | 0 | None | -14125 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 419 | 2 | 1 | 3 | 5.7 | COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1 | 10.1016/j.bmcl.2009.12.094 | ||
11439190 | 199620 | 0 | None | -3548 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 338 | 0 | 1 | 3 | 3.9 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL604127 | 199620 | 0 | None | -3548 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 338 | 0 | 1 | 3 | 3.9 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
46231995 | 199849 | 0 | None | -16595 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 434 | 2 | 1 | 4 | 5.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL605339 | 199849 | 0 | None | -16595 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 434 | 2 | 1 | 4 | 5.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
46231927 | 199851 | 0 | None | -10000 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 432 | 3 | 1 | 4 | 5.4 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL605354 | 199851 | 0 | None | -10000 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 432 | 3 | 1 | 4 | 5.4 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
164627027 | 185845 | 0 | None | -50 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 466 | 5 | 3 | 4 | 4.3 | O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4876260 | 185845 | 0 | None | -50 | 4 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 466 | 5 | 3 | 4 | 4.3 | O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1 | 10.1016/j.bmcl.2021.128047 | ||
863787 | 65959 | 13 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184772 | 65959 | 13 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1016/j.bmcl.2004.07.068 | ||
168276065 | 189626 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 4.0 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(C#N)cc3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5174753 | 189626 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 4.0 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(C#N)cc3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
44395711 | 174327 | 0 | None | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL456430 | 174327 | 0 | None | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL537183 | 174327 | 0 | None | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
44395711 | 174327 | 0 | None | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL456430 | 174327 | 0 | None | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL537183 | 174327 | 0 | None | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL5085974 | 213231 | 0 | None | -123 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | None | None | None | CN(C)C(=O)C(CCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
44309775 | 102205 | 0 | None | -288 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm049465g | ||
CHEMBL304605 | 102205 | 0 | None | -288 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm049465g | ||
44309775 | 102205 | 0 | None | -288 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm0704200 | ||
CHEMBL304605 | 102205 | 0 | None | -288 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm0704200 | ||
44309775 | 102205 | 0 | None | -288 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm040190e | ||
CHEMBL304605 | 102205 | 0 | None | -288 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm040190e | ||
72737772 | 114023 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 295 | 5 | 0 | 2 | 3.8 | Cc1ccccc1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
CHEMBL3335541 | 114023 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 295 | 5 | 0 | 2 | 3.8 | Cc1ccccc1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
56664948 | 66100 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 434 | 7 | 2 | 5 | 3.7 | O=C1CCc2ccc(OCCCCN3CCC(n4c(=O)[nH]c5ccccc54)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813587 | 66100 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 434 | 7 | 2 | 5 | 3.7 | O=C1CCc2ccc(OCCCCN3CCC(n4c(=O)[nH]c5ccccc54)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851962 | 66100 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 434 | 7 | 2 | 5 | 3.7 | O=C1CCc2ccc(OCCCCN3CCC(n4c(=O)[nH]c5ccccc54)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
44431482 | 87608 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234473 | 87608 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.ejmech.2006.12.030 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.ejmech.2006.12.030 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.ejmech.2006.12.030 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.ejmech.2006.12.030 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.ejmech.2006.12.030 | ||
10512444 | 24706 | 0 | None | -1445 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 205 | 2 | 1 | 2 | 2.2 | CCN(C)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL134571 | 24706 | 0 | None | -1445 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 205 | 2 | 1 | 2 | 2.2 | CCN(C)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
155536631 | 171654 | 0 | None | -2 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 4 | 0 | 3 | 3.5 | Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4474014 | 171654 | 0 | None | -2 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 4 | 0 | 3 | 3.5 | Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 | 10.1016/j.bmc.2020.115943 | ||
155536631 | 171654 | 0 | None | -2 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 4 | 0 | 3 | 3.5 | Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4474014 | 171654 | 0 | None | -2 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 4 | 0 | 3 | 3.5 | Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2 | 10.1016/j.bmc.2020.115943 | ||
42625295 | 55958 | 0 | None | -4073 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
CHEMBL1627321 | 55958 | 0 | None | -4073 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
164612428 | 184580 | 0 | None | -14 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.9 | COc1ccc(C(=O)NCc2ccccc2CN2CCc3cc(OC)c(O)cc3C2)cc1 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4857166 | 184580 | 0 | None | -14 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.9 | COc1ccc(C(=O)NCc2ccccc2CN2CCc3cc(OC)c(O)cc3C2)cc1 | 10.1016/j.bmcl.2021.128047 | ||
168296347 | 191864 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 344 | 6 | 0 | 4 | 3.7 | COc1ccc(CN2CCC[C@H](OCc3cccc(C)n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5208643 | 191864 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 344 | 6 | 0 | 4 | 3.7 | COc1ccc(CN2CCC[C@H](OCc3cccc(C)n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
154725484 | 175891 | 1 | None | -478 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4439544 | 175891 | 1 | None | -478 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596514 | 175891 | 1 | None | -478 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
10983150 | 102515 | 0 | None | -18 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 0 | 4 | 4.6 | O=C1c2ccccc2C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/jm010146o | ||
CHEMBL306672 | 102515 | 0 | None | -18 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 0 | 4 | 4.6 | O=C1c2ccccc2C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/jm010146o | ||
763625 | 91716 | 7 | None | 19 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 276 | 3 | 0 | 3 | 3.2 | Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420775 | 91716 | 7 | None | 19 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 276 | 3 | 0 | 3 | 3.2 | Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
60165412 | 75009 | 0 | None | -28 | 6 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 7 | 0 | 5 | 4.5 | O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037530 | 75009 | 0 | None | -28 | 6 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 7 | 0 | 5 | 4.5 | O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
130431351 | 172600 | 0 | None | -3090 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 468 | 9 | 2 | 4 | 4.7 | CCc1cc(Cl)c(OC)c(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4521947 | 172600 | 0 | None | -3090 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 468 | 9 | 2 | 4 | 4.7 | CCc1cc(Cl)c(OC)c(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
23288790 | 202266 | 0 | None | -123 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | ||
CHEMBL69385 | 202266 | 0 | None | -123 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 395 | 6 | 1 | 5 | 2.6 | COc1ccc(N2CCN(CCC3OCCc4cc(C(N)=O)ccc43)CC2)cc1 | 10.1021/jm980137o | ||
9885219 | 55982 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(OC[C@H]2CC[C@@H]3CN(c4ncc(F)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL162873 | 55982 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(OC[C@H]2CC[C@@H]3CN(c4ncc(F)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
127031833 | 138865 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1cccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c12 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793347 | 138865 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1cccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c12 | 10.1016/j.bmcl.2016.03.102 | ||
135506137 | 11229 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 352 | 5 | 1 | 7 | 1.7 | c1cnc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1179504 | 11229 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 352 | 5 | 1 | 7 | 1.7 | c1cnc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL80655 | 11229 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 352 | 5 | 1 | 7 | 1.7 | c1cnc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
10065188 | 101133 | 0 | None | 3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL298763 | 101133 | 0 | None | 3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
11408148 | 128198 | 0 | None | -275 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 4.8 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm049465g | ||
CHEMBL366904 | 128198 | 0 | None | -275 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 4.8 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm049465g | ||
11408148 | 128198 | 0 | None | -275 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 4.8 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm900095y | ||
CHEMBL366904 | 128198 | 0 | None | -275 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 4.8 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm900095y | ||
164623294 | 185241 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.9 | COc1cccc(C(=O)NCc2ccccc2CN2CCc3cc(OC)c(O)cc3C2)c1 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4867331 | 185241 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.9 | COc1cccc(C(=O)NCc2ccccc2CN2CCc3cc(OC)c(O)cc3C2)c1 | 10.1016/j.bmcl.2021.128047 | ||
11408148 | 128198 | 0 | None | -275 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 4.8 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL366904 | 128198 | 0 | None | -275 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 443 | 6 | 1 | 4 | 4.8 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
72737725 | 114027 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.8 | Fc1cccc(F)c1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
CHEMBL3335545 | 114027 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.8 | Fc1cccc(F)c1CN1CCOC(CCc2ccccc2)C1 | 10.1021/ml500267c | ||
4350931 | 168747 | 39 | None | -1348 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1039/C5MD00258C | ||
CHEMBL441618 | 168747 | 39 | None | -1348 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1039/C5MD00258C | ||
44336154 | 5367 | 0 | None | 8 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 411 | 4 | 0 | 3 | 4.2 | CC1N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc2C1(C)C | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107384 | 5367 | 0 | None | 8 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 411 | 4 | 0 | 3 | 4.2 | CC1N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc2C1(C)C | 10.1016/s0960-894x(02)00655-8 | ||
4350931 | 168747 | 39 | None | -1348 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | ||
CHEMBL441618 | 168747 | 39 | None | -1348 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | ||
21302490 | 112308 | 26 | None | -12 | 9 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 3.9 | CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 | 10.1021/jm401958n | ||
CHEMBL3233142 | 112308 | 26 | None | -12 | 9 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 3.9 | CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 | 10.1021/jm401958n | ||
CHEMBL3306803 | 112308 | 26 | None | -12 | 9 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 3.9 | CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 | 10.1021/jm401958n | ||
188249 | 39415 | 4 | None | 1 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 328 | 0 | 0 | 5 | 3.2 | CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1 | 10.1021/jm2013419 | ||
CHEMBL147463 | 39415 | 4 | None | 1 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 328 | 0 | 0 | 5 | 3.2 | CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1 | 10.1021/jm2013419 | ||
CHEMBL2022280 | 39415 | 4 | None | 1 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 328 | 0 | 0 | 5 | 3.2 | CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1 | 10.1021/jm2013419 | ||
10363821 | 38801 | 0 | None | 91 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 403 | 2 | 1 | 5 | 4.7 | Clc1ccc2c(c1)C(N1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL146856 | 38801 | 0 | None | 91 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 403 | 2 | 1 | 5 | 4.7 | Clc1ccc2c(c1)C(N1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
10807035 | 205005 | 0 | None | 107 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 2 | 0 | 3 | 4.3 | Cc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(Cl)cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL89921 | 205005 | 0 | None | 107 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 2 | 0 | 3 | 4.3 | Cc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(Cl)cc1)CC3 | 10.1021/jm970170v | ||
10615437 | 95495 | 1 | None | 6 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.5 | c1ccc(CN2CCC(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL25938 | 95495 | 1 | None | 6 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.5 | c1ccc(CN2CCC(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
15467370 | 101848 | 0 | None | 2818 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 3.4 | N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL303538 | 101848 | 0 | None | 2818 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 3.4 | N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
289 | 240 | 6 | None | 1 | 14 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 301 | 8 | 0 | 2 | 4.9 | CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C | 10.1021/jm100697g | ||
9948320 | 240 | 6 | None | 1 | 14 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 301 | 8 | 0 | 2 | 4.9 | CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C | 10.1021/jm100697g | ||
CHEMBL1242950 | 240 | 6 | None | 1 | 14 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 301 | 8 | 0 | 2 | 4.9 | CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C | 10.1021/jm100697g | ||
72164301 | 91727 | 0 | None | 3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 320 | 3 | 0 | 2 | 4.3 | Clc1cccc(N2CCN(Cc3ccccc3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420893 | 91727 | 0 | None | 3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 320 | 3 | 0 | 2 | 4.3 | Clc1cccc(N2CCN(Cc3ccccc3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
44330553 | 167636 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 216 | 0 | 0 | 3 | 2.8 | Cc1oc(C)c2c1CCCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL433376 | 167636 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 216 | 0 | 0 | 3 | 2.8 | Cc1oc(C)c2c1CCCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
10590285 | 19854 | 1 | None | 21 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCCNCCOc2ccc(C)cc2)cc1 | 10.1021/jm970422s | ||
CHEMBL130370 | 19854 | 1 | None | 21 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 299 | 9 | 1 | 3 | 3.7 | Cc1ccc(OCCCNCCOc2ccc(C)cc2)cc1 | 10.1021/jm970422s | ||
44335909 | 110851 | 0 | None | 12 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 427 | 6 | 0 | 4 | 3.8 | CCOc1ccc(Cl)cc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL326863 | 110851 | 0 | None | 12 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 427 | 6 | 0 | 4 | 3.8 | CCOc1ccc(Cl)cc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
10926404 | 46597 | 8 | None | 28 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 357 | 6 | 1 | 4 | 2.4 | COc1cccc(C(=O)NCCN2CCN(c3ccc(F)cc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL154050 | 46597 | 8 | None | 28 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 357 | 6 | 1 | 4 | 2.4 | COc1cccc(C(=O)NCCN2CCN(c3ccc(F)cc3)CC2)c1 | 10.1021/jm020952a | ||
44335853 | 4790 | 0 | None | 478 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 3.8 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C(F)(F)F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104321 | 4790 | 0 | None | 478 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 3.8 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C(F)(F)F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
10782946 | 15397 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccc(N2CCN(Cc3ccc4oc(=O)ccc4c3)CC2)cc1 | 10.1021/jm990266k | ||
CHEMBL122049 | 15397 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccc(N2CCN(Cc3ccc4oc(=O)ccc4c3)CC2)cc1 | 10.1021/jm990266k | ||
9906978 | 42466 | 1 | None | 1 | 12 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL150161 | 42466 | 1 | None | 1 | 12 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
2435 | 3533 | 78 | None | -10 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | ||
60149 | 3533 | 78 | None | -10 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | ||
98 | 3533 | 78 | None | -10 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | ||
CHEMBL12713 | 3533 | 78 | None | -10 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | ||
DB06144 | 3533 | 78 | None | -10 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm020938y | ||
145969934 | 164493 | 0 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 261 | 7 | 1 | 2 | 4.2 | CCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4226336 | 164493 | 0 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 261 | 7 | 1 | 2 | 4.2 | CCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
11504230 | 77840 | 0 | None | -12 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 497 | 8 | 1 | 4 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm100899z | ||
CHEMBL210567 | 77840 | 0 | None | -12 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 497 | 8 | 1 | 4 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm100899z | ||
11393666 | 192384 | 0 | None | -28 | 19 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | ||
CHEMBL5201983 | 192384 | 0 | None | -28 | 19 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | ||
CHEMBL5222597 | 192384 | 0 | None | -28 | 19 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | ||
CHEMBL4435399 | 212176 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | O=[N+]([O-])c1ccc(CN2CCC(n3cc(Cc4ccc(Br)cc4)nn3)CC2)cc1 | 10.1016/j.bmc.2022.116851 | ||||
16725912 | 85302 | 13 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
16725912 | 85302 | 13 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL228972 | 85302 | 13 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL228972 | 85302 | 13 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
44431489 | 87843 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1cccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234825 | 87843 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1cccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
53364155 | 63513 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1041 | 33 | 0 | 16 | 10.2 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803026 | 63513 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1041 | 33 | 0 | 16 | 10.2 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
137632761 | 156033 | 0 | None | -13 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 476 | 8 | 3 | 9 | 2.7 | O=c1ccc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2[nH]1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4068561 | 156033 | 0 | None | -13 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 476 | 8 | 3 | 9 | 2.7 | O=c1ccc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2[nH]1 | 10.1016/j.bmc.2017.08.037 | ||
137640203 | 156420 | 0 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 452 | 10 | 0 | 8 | 3.5 | CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4072821 | 156420 | 0 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 452 | 10 | 0 | 8 | 3.5 | CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1 | 10.1021/acs.jmedchem.6b01857 | ||
10615437 | 95495 | 1 | None | 6 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.5 | c1ccc(CN2CCC(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL25938 | 95495 | 1 | None | 6 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.5 | c1ccc(CN2CCC(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
71733935 | 90552 | 0 | None | -43 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm400520c | ||
CHEMBL2396663 | 90552 | 0 | None | -43 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm400520c | ||
10615437 | 95495 | 1 | None | 6 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.5 | c1ccc(CN2CCC(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1016/j.bmc.2022.116851 | ||
CHEMBL25938 | 95495 | 1 | None | 6 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.5 | c1ccc(CN2CCC(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1016/j.bmc.2022.116851 | ||
9865446 | 123533 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | OCc1ccc(N2CCN(CCC(O)c3ccc(Cl)cc3)CC2)cc1Cl | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL36313 | 123533 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | OCc1ccc(N2CCN(CCC(O)c3ccc(Cl)cc3)CC2)cc1Cl | 10.1016/s0960-894x(98)00252-2 | ||
10479188 | 201184 | 0 | None | 5 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 5 | 4.7 | COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL62602 | 201184 | 0 | None | 5 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 5 | 4.7 | COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
9949531 | 204883 | 0 | None | -11 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 333 | 6 | 3 | 4 | 3.7 | Sc1nc2c(OCCNCc3ccccc3)cc(Cl)cc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL89037 | 204883 | 0 | None | -11 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 333 | 6 | 3 | 4 | 3.7 | Sc1nc2c(OCCNCc3ccccc3)cc(Cl)cc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
44369020 | 118954 | 0 | None | -2 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 374 | 6 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/jm100925m | ||
CHEMBL345111 | 118954 | 0 | None | -2 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 374 | 6 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/jm100925m | ||
11558055 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1039/C5MD00258C | ||
CHEMBL1204122 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1039/C5MD00258C | ||
CHEMBL201170 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1039/C5MD00258C | ||
11558055 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL1204122 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL201170 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmc.2009.08.028 | ||
11558055 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | ||
CHEMBL1204122 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | ||
CHEMBL201170 | 72805 | 1 | None | -17 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | ||
11772112 | 168251 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1C | 10.1021/jm060279f | ||
CHEMBL437687 | 168251 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1C | 10.1021/jm060279f | ||
44278427 | 98883 | 0 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 327 | 7 | 1 | 4 | 3.0 | O[C@H](COc1ccccc1)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL282323 | 98883 | 0 | None | 39 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 327 | 7 | 1 | 4 | 3.0 | O[C@H](COc1ccccc1)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
127031518 | 138869 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793389 | 138869 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
127029995 | 138967 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794529 | 138967 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1F | 10.1016/j.bmcl.2016.03.102 | ||
11849266 | 80657 | 0 | None | 5 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.6 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(C)c1 | 10.1021/jm060279f | ||
CHEMBL215450 | 80657 | 0 | None | 5 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.6 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(C)c1 | 10.1021/jm060279f | ||
44370047 | 119171 | 0 | None | 4 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 340 | 4 | 1 | 3 | 3.5 | Clc1ccc(N2CCN(CCc3cc4ccc[nH]c-4n3)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL347155 | 119171 | 0 | None | 4 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 340 | 4 | 1 | 3 | 3.5 | Clc1ccc(N2CCN(CCc3cc4ccc[nH]c-4n3)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
13091268 | 77845 | 0 | None | -8 | 14 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2003.07.015 | ||
CHEMBL210578 | 77845 | 0 | None | -8 | 14 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2003.07.015 | ||
10378389 | 201554 | 1 | None | -53 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | ||
CHEMBL134807 | 201554 | 1 | None | -53 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | ||
CHEMBL64553 | 201554 | 1 | None | -53 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | ||
10378389 | 201554 | 1 | None | -53 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | ||
CHEMBL134807 | 201554 | 1 | None | -53 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | ||
CHEMBL64553 | 201554 | 1 | None | -53 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | ||
10497193 | 203229 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 337 | 4 | 1 | 2 | 4.7 | Clc1ccc(-c2cc(C3CCN(Cc4ccccc4)C3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL76355 | 203229 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 337 | 4 | 1 | 2 | 4.7 | Clc1ccc(-c2cc(C3CCN(Cc4ccccc4)C3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10738530 | 203326 | 0 | None | 5 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 6 | 1 | 2 | 5.5 | Clc1ccc(-c2cc(C3CCN(CCCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL77017 | 203326 | 0 | None | 5 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 6 | 1 | 2 | 5.5 | Clc1ccc(-c2cc(C3CCN(CCCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10790517 | 205878 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 469 | 7 | 2 | 4 | 4.9 | COc1cc(NC(=O)C2CCCCC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL95096 | 205878 | 0 | None | 1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 469 | 7 | 2 | 4 | 4.9 | COc1cc(NC(=O)C2CCCCC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
6603867 | 101524 | 16 | None | -56 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@@H]1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL301559 | 101524 | 16 | None | -56 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@@H]1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
57345618 | 70116 | 0 | None | -1 | 6 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 362 | 6 | 0 | 3 | 4.5 | Fc1ccc(OCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946126 | 70116 | 0 | None | -1 | 6 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 362 | 6 | 0 | 3 | 4.5 | Fc1ccc(OCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
92984956 | 138950 | 1 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccc(OC)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794363 | 138950 | 1 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccc(OC)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
11164276 | 79342 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
CHEMBL211732 | 79342 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
11154555 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
5037 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
7671 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
CHEMBL2028019 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
CHEMBL3085826 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
DB06016 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
11154555 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | ||
5037 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | ||
7671 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | ||
CHEMBL2028019 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | ||
CHEMBL3085826 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | ||
DB06016 | 788 | 57 | None | -501 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | ||
10830557 | 31086 | 0 | None | 4 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1 | 10.1021/jm0009989 | ||
CHEMBL140165 | 31086 | 0 | None | 4 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 334 | 3 | 1 | 3 | 3.5 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1 | 10.1021/jm0009989 | ||
44436600 | 91370 | 0 | None | -109 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 391 | 8 | 1 | 4 | 3.0 | C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241212 | 91370 | 0 | None | -109 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 391 | 8 | 1 | 4 | 3.0 | C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
71734126 | 90623 | 0 | None | -10 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397391 | 90623 | 0 | None | -10 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm400520c | ||
44372312 | 53503 | 0 | None | 43 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160396 | 53503 | 0 | None | 43 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1016/s0960-894x(01)00814-9 | ||
72737734 | 114024 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1cccc(CN2CCOC(CCc3ccccc3)C2)c1 | 10.1021/ml500267c | ||
CHEMBL3335542 | 114024 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1cccc(CN2CCOC(CCc3ccccc3)C2)c1 | 10.1021/ml500267c | ||
155536815 | 171641 | 0 | None | 33 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473792 | 171641 | 0 | None | 33 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 322 | 4 | 1 | 2 | 4.1 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1021/acs.jmedchem.9b00231 | ||
133633 | 2210 | 46 | None | -104 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1021/jm800532x | ||
177 | 2210 | 46 | None | -104 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1021/jm800532x | ||
CHEMBL445102 | 2210 | 46 | None | -104 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1021/jm800532x | ||
44438201 | 93174 | 2 | None | -158 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 374 | 3 | 2 | 2 | 5.0 | OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246637 | 93174 | 2 | None | -158 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 374 | 3 | 2 | 2 | 5.0 | OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
25139329 | 186520 | 0 | None | -7 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 514 | 10 | 0 | 4 | 7.6 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1 | 10.1021/jm800895v | ||
CHEMBL491466 | 186520 | 0 | None | -7 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 514 | 10 | 0 | 4 | 7.6 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1 | 10.1021/jm800895v | ||
2779264 | 110854 | 36 | None | 8 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 240 | 3 | 0 | 2 | 3.3 | c1ccc(CN2CCC(n3cccc3)CC2)cc1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL326877 | 110854 | 36 | None | 8 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 240 | 3 | 0 | 2 | 3.3 | c1ccc(CN2CCC(n3cccc3)CC2)cc1 | 10.1016/s0960-894x(99)00540-5 | ||
134151428 | 154015 | 0 | None | -44 | 9 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 291 | 3 | 0 | 2 | 3.5 | O=C1c2ccccc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3978642 | 154015 | 0 | None | -44 | 9 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 291 | 3 | 0 | 2 | 3.5 | O=C1c2ccccc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991094 | 154015 | 0 | None | -44 | 9 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 291 | 3 | 0 | 2 | 3.5 | O=C1c2ccccc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
17755999 | 142353 | 1 | None | -190 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2 | 10.1021/jm070388+ | ||
CHEMBL389357 | 142353 | 1 | None | -190 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2 | 10.1021/jm070388+ | ||
3117 | 206106 | 100 | None | -2 | 16 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
CHEMBL964 | 206106 | 100 | None | -2 | 16 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
44304644 | 201560 | 0 | None | 1 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 454 | 8 | 2 | 4 | 4.5 | COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64566 | 201560 | 0 | None | 1 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 454 | 8 | 2 | 4 | 4.5 | COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1 | 10.1016/s0960-894x(00)00405-4 | ||
10436285 | 101482 | 0 | None | -954 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm040190e | ||
CHEMBL301242 | 101482 | 0 | None | -954 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm040190e | ||
10301202 | 13391 | 0 | None | -70 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 511 | 11 | 0 | 6 | 6.1 | COc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1193508 | 13391 | 0 | None | -70 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 511 | 11 | 0 | 6 | 6.1 | COc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL544925 | 13391 | 0 | None | -70 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 511 | 11 | 0 | 6 | 6.1 | COc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
11211058 | 79924 | 0 | None | 8 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(\c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL214247 | 79924 | 0 | None | 8 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(\c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
44393737 | 65430 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 646 | 4 | 1 | 4 | 5.7 | Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)c1Br | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL183466 | 65430 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 646 | 4 | 1 | 4 | 5.7 | Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)c1Br | 10.1016/j.bmcl.2004.07.068 | ||
154703824 | 176052 | 1 | None | -436 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4456007 | 176052 | 1 | None | -436 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597876 | 176052 | 1 | None | -436 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
145967904 | 164545 | 0 | None | 1 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 247 | 6 | 1 | 2 | 3.8 | CCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4227192 | 164545 | 0 | None | 1 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 247 | 6 | 1 | 2 | 3.8 | CCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
11812838 | 202187 | 0 | None | -47 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 5.4 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)C1c2ccccc2-c2ccccc21 | 10.1021/jm010146o | ||
CHEMBL68860 | 202187 | 0 | None | -47 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 5.4 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)C1c2ccccc2-c2ccccc21 | 10.1021/jm010146o | ||
154726046 | 175737 | 1 | None | -288 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4442408 | 175737 | 1 | None | -288 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595266 | 175737 | 1 | None | -288 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
136094867 | 40328 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 443 | 3 | 2 | 5 | 5.7 | Clc1ccc2c(c1)C(NC1CC3CCC(C1)N3Cc1ccccc1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL148353 | 40328 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 443 | 3 | 2 | 5 | 5.7 | Clc1ccc2c(c1)C(NC1CC3CCC(C1)N3Cc1ccccc1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
155511803 | 169038 | 0 | None | 229 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 342 | 4 | 1 | 2 | 4.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4436479 | 169038 | 0 | None | 229 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 342 | 4 | 1 | 2 | 4.5 | Cc1cccc(NC(=O)CN2CCC(c3ccc(Cl)cc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
164622586 | 184954 | 0 | None | -4 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 470 | 6 | 2 | 4 | 5.2 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4862839 | 184954 | 0 | None | -4 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 470 | 6 | 2 | 4 | 5.2 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1cccc(Cl)c1Cl)CC2 | 10.1016/j.bmcl.2021.128047 | ||
168288343 | 190861 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 440 | 6 | 1 | 3 | 5.3 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5193214 | 190861 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 440 | 6 | 1 | 3 | 5.3 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
10378389 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL134807 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL64553 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1016/s0960-894x(01)00778-8 | ||
10378389 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
CHEMBL134807 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
CHEMBL64553 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
10378389 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL134807 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL64553 | 201554 | 1 | None | -53 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1016/s0960-894x(98)00014-6 | ||
44431462 | 87641 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2cccc(Cl)c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234640 | 87641 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2cccc(Cl)c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
10411988 | 21210 | 0 | None | -29 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 5.2 | CC1SC2(CCCC2)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
CHEMBL131482 | 21210 | 0 | None | -29 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 5.2 | CC1SC2(CCCC2)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
122334 | 319 | 19 | None | -2 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.1 | CCCN[C@@H]1CCc2c([C@@H]1C)cccc2OC | 10.1016/S0960-894X(01)80181-5 | ||
970 | 319 | 19 | None | -2 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.1 | CCCN[C@@H]1CCc2c([C@@H]1C)cccc2OC | 10.1016/S0960-894X(01)80181-5 | ||
CHEMBL27441 | 319 | 19 | None | -2 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.1 | CCCN[C@@H]1CCc2c([C@@H]1C)cccc2OC | 10.1016/S0960-894X(01)80181-5 | ||
122334 | 319 | 19 | None | -2 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.1 | CCCN[C@@H]1CCc2c([C@@H]1C)cccc2OC | 10.1021/jm00073a021 | ||
970 | 319 | 19 | None | -2 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.1 | CCCN[C@@H]1CCc2c([C@@H]1C)cccc2OC | 10.1021/jm00073a021 | ||
CHEMBL27441 | 319 | 19 | None | -2 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 1 | 2 | 3.1 | CCCN[C@@H]1CCc2c([C@@H]1C)cccc2OC | 10.1021/jm00073a021 | ||
22727358 | 13113 | 0 | None | -7 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 7 | 0 | 5 | 4.5 | c1ccc(N2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191251 | 13113 | 0 | None | -7 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 7 | 0 | 5 | 4.5 | c1ccc(N2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL542324 | 13113 | 0 | None | -7 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 7 | 0 | 5 | 4.5 | c1ccc(N2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
127049059 | 140282 | 0 | None | -11 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 3.6 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818935 | 140282 | 0 | None | -11 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 3.6 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
85658088 | 164451 | 0 | None | -3 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 3.0 | CCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4225830 | 164451 | 0 | None | -3 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 3.0 | CCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
127049059 | 140282 | 0 | None | -11 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 3.6 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818935 | 140282 | 0 | None | -11 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 3.6 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
72205222 | 91516 | 0 | None | -7 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 408 | 8 | 0 | 4 | 5.1 | Clc1ccc(-n2cc(CCCCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL2414358 | 91516 | 0 | None | -7 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 408 | 8 | 0 | 4 | 5.1 | Clc1ccc(-n2cc(CCCCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
162669562 | 182120 | 0 | None | -2 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 4.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4789472 | 182120 | 0 | None | -2 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 4.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
44431467 | 153896 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2cccc(C(F)(F)F)c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL398990 | 153896 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2cccc(C(F)(F)F)c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
44438229 | 154360 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 380 | 6 | 1 | 2 | 5.5 | C=CCOC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL400826 | 154360 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 380 | 6 | 1 | 2 | 5.5 | C=CCOC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
142590728 | 180940 | 0 | None | -3 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 446 | 7 | 1 | 3 | 5.4 | CC(C)(C)C(=O)N1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4765081 | 180940 | 0 | None | -3 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 446 | 7 | 1 | 3 | 5.4 | CC(C)(C)C(=O)N1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
10618211 | 78193 | 0 | None | 10 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 355 | 5 | 1 | 3 | 4.7 | O=C(/C=C(\O)c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1 | 10.1021/jm970111h | ||
CHEMBL2112285 | 78193 | 0 | None | 10 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 355 | 5 | 1 | 3 | 4.7 | O=C(/C=C(\O)c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1 | 10.1021/jm970111h | ||
44300865 | 200310 | 0 | None | 16 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.0 | c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL60815 | 200310 | 0 | None | 16 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.0 | c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
10424172 | 13676 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 287 | 1 | 0 | 1 | 4.4 | CN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL1195497 | 13676 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 287 | 1 | 0 | 1 | 4.4 | CN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL554670 | 13676 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 287 | 1 | 0 | 1 | 4.4 | CN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
44323894 | 167537 | 0 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 304 | 1 | 0 | 2 | 3.9 | CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
CHEMBL432762 | 167537 | 0 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 304 | 1 | 0 | 2 | 3.9 | CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
10619612 | 172111 | 0 | None | 9 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 4.4 | COc1ccc(-c2nc(O)n(C3CCN(Cc4ccccc4)CC3)c2C)cc1 | 10.1021/jm991029k | ||
CHEMBL450021 | 172111 | 0 | None | 9 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 4.4 | COc1ccc(-c2nc(O)n(C3CCN(Cc4ccccc4)CC3)c2C)cc1 | 10.1021/jm991029k | ||
44323894 | 167537 | 0 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 304 | 1 | 0 | 2 | 3.9 | CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL432762 | 167537 | 0 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 304 | 1 | 0 | 2 | 3.9 | CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
10617381 | 189094 | 0 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm970021c | ||
CHEMBL51536 | 189094 | 0 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1021/jm970021c | ||
44454710 | 155125 | 0 | None | 70 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 4.0 | COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL404888 | 155125 | 0 | None | 70 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 4.0 | COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF | 10.1016/j.bmcl.2007.12.026 | ||
9859861 | 167517 | 1 | None | 173 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 218 | 0 | 1 | 2 | 3.2 | Cc1sc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL432579 | 167517 | 1 | None | 173 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 218 | 0 | 1 | 2 | 3.2 | Cc1sc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
44335973 | 4965 | 0 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(Cl)ccc2Cl)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL105172 | 4965 | 0 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(Cl)ccc2Cl)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335893 | 108118 | 0 | None | 16 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 419 | 4 | 0 | 3 | 3.7 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(F)c(F)c2Cl)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL320515 | 108118 | 0 | None | 16 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 419 | 4 | 0 | 3 | 3.7 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(F)c(F)c2Cl)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335746 | 5623 | 0 | None | 251 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 385 | 4 | 0 | 3 | 3.1 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(F)cc(F)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107804 | 5623 | 0 | None | 251 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 385 | 4 | 0 | 3 | 3.1 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(F)cc(F)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335829 | 108109 | 0 | None | 147 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 391 | 5 | 0 | 3 | 3.9 | CC(C)c1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL320440 | 108109 | 0 | None | 147 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 391 | 5 | 0 | 3 | 3.9 | CC(C)c1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
44335828 | 162905 | 0 | None | 158 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 405 | 4 | 0 | 3 | 4.1 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C(C)(C)C)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL419916 | 162905 | 0 | None | 158 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 405 | 4 | 0 | 3 | 4.1 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C(C)(C)C)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
155561779 | 175192 | 0 | None | 9 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 566 | 10 | 2 | 6 | 5.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(C#N)cc2)c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4583596 | 175192 | 0 | None | 9 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 566 | 10 | 2 | 6 | 5.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(C#N)cc2)c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
44374863 | 119702 | 0 | None | 13 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 403 | 3 | 0 | 3 | 3.8 | Cc1ccc(CN2CCN(C3CCc4cccc5c4N(C3=O)C(C)(C)C5)CC2)cc1 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL351989 | 119702 | 0 | None | 13 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 403 | 3 | 0 | 3 | 3.8 | Cc1ccc(CN2CCN(C3CCc4cccc5c4N(C3=O)C(C)(C)C5)CC2)cc1 | 10.1016/s0960-894x(02)01056-9 | ||
90644057 | 111540 | 0 | None | 28 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.7 | FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289645 | 111540 | 0 | None | 28 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.7 | FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
13091268 | 77845 | 0 | None | -13 | 14 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL210578 | 77845 | 0 | None | -13 | 14 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
53364226 | 63515 | 0 | None | -3 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 989 | 29 | 0 | 18 | 6.3 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803028 | 63515 | 0 | None | -3 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 989 | 29 | 0 | 18 | 6.3 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
53363201 | 63524 | 0 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 893 | 27 | 0 | 15 | 7.0 | COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803054 | 63524 | 0 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 893 | 27 | 0 | 15 | 7.0 | COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
44300865 | 200310 | 0 | None | 16 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.0 | c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL60815 | 200310 | 0 | None | 16 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 317 | 4 | 1 | 2 | 4.0 | c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
44436599 | 91369 | 0 | None | 5 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 477 | 5 | 1 | 3 | 4.9 | O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241211 | 91369 | 0 | None | 5 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 477 | 5 | 1 | 3 | 4.9 | O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1 | 10.1016/j.bmc.2007.08.038 | ||
44222483 | 194577 | 0 | None | -2 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 3.0 | CSc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
CHEMBL561763 | 194577 | 0 | None | -2 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 3.0 | CSc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
45271653 | 193565 | 0 | None | 851 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 2.7 | COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL550920 | 193565 | 0 | None | 851 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 2.7 | COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1 | 10.1016/j.bmc.2009.05.015 | ||
10251080 | 13846 | 0 | None | -3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 9 | 0 | 6 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1196692 | 13846 | 0 | None | -3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 9 | 0 | 6 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL557829 | 13846 | 0 | None | -3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 9 | 0 | 6 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
13091268 | 77845 | 0 | None | -8 | 14 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2003.07.015 | ||
CHEMBL210578 | 77845 | 0 | None | -8 | 14 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2003.07.015 | ||
10617381 | 189094 | 0 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL51536 | 189094 | 0 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
11792373 | 119317 | 0 | None | 457 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 353 | 4 | 1 | 5 | 2.3 | COc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL348435 | 119317 | 0 | None | 457 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 353 | 4 | 1 | 5 | 2.3 | COc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
127053214 | 138819 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 311 | 5 | 0 | 3 | 3.6 | Cc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792923 | 138819 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 311 | 5 | 0 | 3 | 3.6 | Cc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
76282192 | 192431 | 0 | None | 724 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 320 | 5 | 0 | 4 | 3.2 | c1ccc(N2CCN(CCCn3cnc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5207313 | 192431 | 0 | None | 724 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 320 | 5 | 0 | 4 | 3.2 | c1ccc(N2CCN(CCCn3cnc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222877 | 192431 | 0 | None | 724 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 320 | 5 | 0 | 4 | 3.2 | c1ccc(N2CCN(CCCn3cnc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
9949601 | 99591 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 335 | 4 | 1 | 3 | 3.0 | Cc1ccc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL287078 | 99591 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 335 | 4 | 1 | 3 | 3.0 | Cc1ccc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
44264644 | 203035 | 0 | None | 87 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 330 | 3 | 0 | 4 | 3.2 | Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7442 | 203035 | 0 | None | 87 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 330 | 3 | 0 | 4 | 3.2 | Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
155563301 | 174678 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4572245 | 174678 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
44273927 | 75194 | 0 | None | 125 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 9 | 1 | 3 | 4.2 | CCCC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20444 | 75194 | 0 | None | 125 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 9 | 1 | 3 | 4.2 | CCCC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
44273924 | 75554 | 0 | None | 199 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 3.4 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20493 | 75554 | 0 | None | 199 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 3.4 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
9863108 | 77722 | 0 | None | -12 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 347 | 7 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CCCCNC(=O)C(C)(C)C)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21008 | 77722 | 0 | None | -12 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 347 | 7 | 1 | 4 | 2.8 | COc1ccccc1N1CCN(CCCCNC(=O)C(C)(C)C)CC1 | 10.1016/0960-894X(96)00198-9 | ||
90644057 | 111540 | 0 | None | 28 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.7 | FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289645 | 111540 | 0 | None | 28 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.7 | FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.12.054 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.12.054 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.12.054 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.12.054 | ||
10382581 | 100828 | 0 | None | 151 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL296506 | 100828 | 0 | None | 151 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
90644067 | 111528 | 0 | None | 48 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 3.8 | [O-][S+](CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289383 | 111528 | 0 | None | 48 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 3.8 | [O-][S+](CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
11724853 | 96572 | 0 | None | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 340 | 0 | 0 | 4 | 3.7 | CN1CCN(C2=Nc3cc(Cl)ccc3N(C)c3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL266723 | 96572 | 0 | None | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 340 | 0 | 0 | 4 | 3.7 | CN1CCN(C2=Nc3cc(Cl)ccc3N(C)c3ccccc32)CC1 | 10.1021/jm00043a008 | ||
12066264 | 14297 | 0 | None | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 469 | 6 | 0 | 2 | 7.4 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2cccc3ccccc23)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
CHEMBL12004 | 14297 | 0 | None | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 469 | 6 | 0 | 2 | 7.4 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2cccc3ccccc23)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
11849182 | 79459 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 2.7 | CO/N=C(/c1ccc(Cl)cc1)C(CNOC)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL212288 | 79459 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 2.7 | CO/N=C(/c1ccc(Cl)cc1)C(CNOC)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
49782836 | 17370 | 0 | None | -12 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 456 | 6 | 0 | 3 | 5.5 | O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
CHEMBL1258036 | 17370 | 0 | None | -12 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 456 | 6 | 0 | 3 | 5.5 | O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
49782837 | 17403 | 0 | None | 3 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 0 | 3 | 6.0 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
CHEMBL1258154 | 17403 | 0 | None | 3 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 0 | 3 | 6.0 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
11706497 | 77812 | 0 | None | -33 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 535 | 7 | 1 | 3 | 6.2 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm060138d | ||
CHEMBL210461 | 77812 | 0 | None | -33 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 535 | 7 | 1 | 3 | 6.2 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm060138d | ||
44436605 | 148531 | 0 | None | -389 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 7 | 1 | 3 | 4.3 | C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL394292 | 148531 | 0 | None | -389 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 7 | 1 | 3 | 4.3 | C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
11517928 | 76750 | 0 | None | 7 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 444 | 4 | 0 | 6 | 4.3 | Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl | 10.1021/jm060166w | ||
CHEMBL207543 | 76750 | 0 | None | 7 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 444 | 4 | 0 | 6 | 4.3 | Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl | 10.1021/jm060166w | ||
45269161 | 194661 | 0 | None | 5 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 336 | 3 | 0 | 6 | 2.4 | Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL562384 | 194661 | 0 | None | 5 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 336 | 3 | 0 | 6 | 2.4 | Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
44381424 | 58762 | 0 | None | 53 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.6 | c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL169562 | 58762 | 0 | None | 53 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.6 | c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
162669562 | 182120 | 0 | None | -2 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 4.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4789472 | 182120 | 0 | None | -2 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 4.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
164623862 | 185423 | 0 | None | -6 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 2.8 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4870361 | 185423 | 0 | None | -6 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 2.8 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 | 10.1016/j.ejmech.2021.113243 | ||
168270809 | 189455 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 6 | 1 | 3 | 4.0 | Cc1cc(NC(=O)CN2CCC(OCc3ccc(F)c(F)c3)CC2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5172055 | 189455 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 6 | 1 | 3 | 4.0 | Cc1cc(NC(=O)CN2CCC(OCc3ccc(F)c(F)c3)CC2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
10826290 | 203772 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 275 | 2 | 1 | 2 | 3.5 | CN1CCC(c2cc(-c3ccc(Cl)cc3)[nH]n2)CC1 | 10.1021/jm970111h | ||
CHEMBL80552 | 203772 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 275 | 2 | 1 | 2 | 3.5 | CN1CCC(c2cc(-c3ccc(Cl)cc3)[nH]n2)CC1 | 10.1021/jm970111h | ||
21219173 | 93022 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 3.2 | c1ccc(CN2CCC(n3nnnc3-c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL24603 | 93022 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 3.2 | c1ccc(CN2CCC(n3nnnc3-c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
44319361 | 204007 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 4 | 0 | 4 | 3.4 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL82527 | 204007 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 4 | 0 | 4 | 3.4 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
71717830 | 85556 | 0 | None | 9 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 433 | 5 | 7 | 9 | -0.3 | OC[C@H]1O[C@H](Oc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)[C@H](O)[C@H](O)[C@H]1O | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL2303762 | 85556 | 0 | None | 9 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 433 | 5 | 7 | 9 | -0.3 | OC[C@H]1O[C@H](Oc2ccc(CC3NCCc4cc(O)c(O)cc43)cc2)[C@H](O)[C@H](O)[C@H]1O | 10.1016/S0960-894X(97)00194-7 | ||
44374637 | 54978 | 0 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 393 | 7 | 0 | 4 | 4.5 | CCCN(CCC)[C@@H]1CCc2c(OS(=O)(=O)C(F)(F)F)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
CHEMBL161811 | 54978 | 0 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 393 | 7 | 0 | 4 | 4.5 | CCCN(CCC)[C@@H]1CCc2c(OS(=O)(=O)C(F)(F)F)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
164623862 | 185423 | 0 | None | -6 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 2.8 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4870361 | 185423 | 0 | None | -6 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 2.8 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21 | 10.1016/j.ejmech.2021.113243 | ||
44591089 | 188892 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 327 | 3 | 2 | 3 | 3.3 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ncccc23)C1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL513776 | 188892 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 327 | 3 | 2 | 3 | 3.3 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ncccc23)C1 | 10.1016/j.bmc.2008.12.054 | ||
57390695 | 70123 | 0 | None | -9 | 8 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946257 | 70123 | 0 | None | -9 | 8 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
57390695 | 70123 | 0 | None | -9 | 8 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL1946257 | 70123 | 0 | None | -9 | 8 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
127052778 | 140314 | 0 | None | -7 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 505 | 9 | 0 | 5 | 6.3 | O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819403 | 140314 | 0 | None | -7 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 505 | 9 | 0 | 5 | 6.3 | O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
164623991 | 184955 | 0 | None | -5 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 10 | 2 | 4 | 4.2 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4862890 | 184955 | 0 | None | -5 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 10 | 2 | 4 | 4.2 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm900095y | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm900095y | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm900095y | ||
3695490 | 100129 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 355 | 8 | 1 | 4 | 3.4 | COc1ccc(OCC(O)CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL29179 | 100129 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 355 | 8 | 1 | 4 | 3.4 | COc1ccc(OCC(O)CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
57345619 | 70120 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 5.0 | Fc1ccc(CCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946253 | 70120 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 5.0 | Fc1ccc(CCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
127050699 | 140341 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 295 | 3 | 0 | 1 | 4.0 | Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819082 | 140341 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 295 | 3 | 0 | 1 | 4.0 | Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819726 | 140341 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 295 | 3 | 0 | 1 | 4.0 | Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2 | 10.1016/j.bmc.2016.05.053 | ||
164623991 | 184955 | 0 | None | -5 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 10 | 2 | 4 | 4.2 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4862890 | 184955 | 0 | None | -5 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 10 | 2 | 4 | 4.2 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
25141533 | 91735 | 0 | None | -676 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 471 | 8 | 2 | 5 | 3.6 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1 | 10.1021/jm0704200 | ||
CHEMBL242218 | 91735 | 0 | None | -676 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 471 | 8 | 2 | 5 | 3.6 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1 | 10.1021/jm0704200 | ||
9888494 | 97719 | 0 | None | -549 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 422 | 4 | 1 | 5 | 3.6 | O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1 | 10.1016/s0960-894x(03)00077-5 | ||
CHEMBL273921 | 97719 | 0 | None | -549 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 422 | 4 | 1 | 5 | 3.6 | O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1 | 10.1016/s0960-894x(03)00077-5 | ||
73213196 | 103981 | 1 | None | -12 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
CHEMBL3104093 | 103981 | 1 | None | -12 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
127052778 | 140314 | 0 | None | -7 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 505 | 9 | 0 | 5 | 6.3 | O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819403 | 140314 | 0 | None | -7 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 505 | 9 | 0 | 5 | 6.3 | O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL5086258 | 213246 | 0 | None | -199 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | Cc1cc(I)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1 | 10.1021/acsmedchemlett.1c00685 | ||||
136094687 | 13327 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 7 | 1 | 6 | 4.2 | c1ccc2c(c1)N=C(NCCCCCN1CCN(c3ccc4ccccc4n3)CC1)CO2 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1192972 | 13327 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 7 | 1 | 6 | 4.2 | c1ccc2c(c1)N=C(NCCCCCN1CCN(c3ccc4ccccc4n3)CC1)CO2 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL544296 | 13327 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 7 | 1 | 6 | 4.2 | c1ccc2c(c1)N=C(NCCCCCN1CCN(c3ccc4ccccc4n3)CC1)CO2 | 10.1016/S0960-894X(97)00442-3 | ||
15467373 | 101384 | 0 | None | 60 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 3.4 | N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL300553 | 101384 | 0 | None | 60 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 3.4 | N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(99)00302-9 | ||
44273715 | 72776 | 0 | None | 15 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 7 | 1 | 3 | 3.0 | CC(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20114 | 72776 | 0 | None | 15 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 7 | 1 | 3 | 3.0 | CC(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
44273877 | 98281 | 0 | None | 15 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 335 | 6 | 1 | 3 | 2.9 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL277937 | 98281 | 0 | None | 15 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 335 | 6 | 1 | 3 | 2.9 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
44273553 | 98332 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 365 | 7 | 1 | 3 | 3.8 | CC(C)(C)C(=O)NCCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL278288 | 98332 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 365 | 7 | 1 | 3 | 3.8 | CC(C)(C)C(=O)NCCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
134155461 | 153950 | 0 | None | -1 | 6 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 291 | 4 | 1 | 2 | 3.6 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3959209 | 153950 | 0 | None | -1 | 6 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 291 | 4 | 1 | 2 | 3.6 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990475 | 153950 | 0 | None | -1 | 6 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 291 | 4 | 1 | 2 | 3.6 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 | 10.1016/j.bmc.2016.09.019 | ||
44273552 | 79520 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 309 | 6 | 1 | 3 | 2.4 | CC(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21252 | 79520 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 309 | 6 | 1 | 3 | 2.4 | CC(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
9827938 | 11666 | 0 | None | -50 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | ||
CHEMBL1181680 | 11666 | 0 | None | -50 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | ||
CHEMBL188486 | 11666 | 0 | None | -50 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 517 | 13 | 1 | 3 | 6.3 | CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1 | 10.1016/j.bmcl.2005.06.024 | ||
57402951 | 70124 | 0 | None | 2 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 413 | 6 | 0 | 5 | 5.1 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946258 | 70124 | 0 | None | 2 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 413 | 6 | 0 | 5 | 5.1 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
57402951 | 70124 | 0 | None | 2 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 413 | 6 | 0 | 5 | 5.1 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL1946258 | 70124 | 0 | None | 2 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 413 | 6 | 0 | 5 | 5.1 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL5071238 | 212482 | 0 | None | -10 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CCc1cccc(N2CCN(CC(O)CCNCCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1Cl | 10.1021/acs.jmedchem.1c00611 | ||||
CHEMBL5070377 | 212464 | 0 | None | -251 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | None | None | None | CN(C)C(=O)C(CCNCCc1ccccc1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
11335419 | 66764 | 1 | None | -125 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 7 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 | 10.1021/jm049720x | ||
CHEMBL187367 | 66764 | 1 | None | -125 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 7 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 | 10.1021/jm049720x | ||
134155461 | 153950 | 0 | None | -1 | 6 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 291 | 4 | 1 | 2 | 3.6 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3959209 | 153950 | 0 | None | -1 | 6 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 291 | 4 | 1 | 2 | 3.6 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990475 | 153950 | 0 | None | -1 | 6 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 291 | 4 | 1 | 2 | 3.6 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2 | 10.1016/j.bmc.2016.09.019 | ||
44376921 | 57027 | 0 | None | 2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 382 | 5 | 0 | 7 | 2.2 | COC(=O)c1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL165113 | 57027 | 0 | None | 2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 382 | 5 | 0 | 7 | 2.2 | COC(=O)c1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
49783415 | 17496 | 0 | None | -1698 | 13 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
CHEMBL1258452 | 17496 | 0 | None | -1698 | 13 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
134133968 | 153986 | 0 | None | -4 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3899099 | 153986 | 0 | None | -4 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990801 | 153986 | 0 | None | -4 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
10476504 | 33268 | 1 | None | -1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
CHEMBL142020 | 33268 | 1 | None | -1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
11663604 | 82760 | 0 | None | -10 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 520 | 13 | 1 | 8 | 3.6 | CCCc1c(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccc(OC)cc1 | 10.1021/jm0611152 | ||
CHEMBL218351 | 82760 | 0 | None | -10 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 520 | 13 | 1 | 8 | 3.6 | CCCc1c(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccc(OC)cc1 | 10.1021/jm0611152 | ||
155539605 | 172276 | 0 | None | -5 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 313 | 1 | 0 | 4 | 2.1 | CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O | 10.1016/j.ejmech.2018.12.048 | ||
CHEMBL4514672 | 172276 | 0 | None | -5 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 313 | 1 | 0 | 4 | 2.1 | CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O | 10.1016/j.ejmech.2018.12.048 | ||
46912548 | 14278 | 0 | None | -144 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 462 | 4 | 2 | 3 | 4.3 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(I)cc4)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173288 | 14278 | 0 | None | -144 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 462 | 4 | 2 | 3 | 4.3 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(I)cc4)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200271 | 14278 | 0 | None | -144 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 462 | 4 | 2 | 3 | 4.3 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(I)cc4)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
44438210 | 92939 | 2 | None | -1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 382 | 4 | 2 | 2 | 5.3 | OC1(c2ccc(-c3ccccc3)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL245615 | 92939 | 2 | None | -1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 382 | 4 | 2 | 2 | 5.3 | OC1(c2ccc(-c3ccccc3)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
134133968 | 153986 | 0 | None | -4 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3899099 | 153986 | 0 | None | -4 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990801 | 153986 | 0 | None | -4 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
42625293 | 55956 | 0 | None | -316 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 549 | 8 | 2 | 6 | 3.3 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1 | 10.1021/jm900095y | ||
CHEMBL1627319 | 55956 | 0 | None | -316 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 549 | 8 | 2 | 6 | 3.3 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1 | 10.1021/jm900095y | ||
44330292 | 4441 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 232 | 0 | 0 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1ncn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL102162 | 4441 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 232 | 0 | 0 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1ncn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
44330515 | 206657 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 246 | 0 | 1 | 2 | 3.9 | Cc1sc(C)c2c1CC(C)(C)Cc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL99654 | 206657 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 246 | 0 | 1 | 2 | 3.9 | Cc1sc(C)c2c1CC(C)(C)Cc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
154706711 | 175941 | 1 | None | -47 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 432 | 11 | 1 | 2 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4439535 | 175941 | 1 | None | -47 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 432 | 11 | 1 | 2 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596930 | 175941 | 1 | None | -47 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 432 | 11 | 1 | 2 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
10760813 | 163537 | 5 | None | 9 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 357 | 4 | 1 | 2 | 5.5 | Clc1ccc(-c2cc(C3CCN(CC4CCCCC4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL420954 | 163537 | 5 | None | 9 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 357 | 4 | 1 | 2 | 5.5 | Clc1ccc(-c2cc(C3CCN(CC4CCCCC4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
44264623 | 203304 | 0 | None | 407 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7686 | 203304 | 0 | None | 407 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
44336138 | 4804 | 0 | None | 75 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 419 | 6 | 0 | 4 | 3.2 | O=S1(=O)Cc2ccccc2N1CCCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104380 | 4804 | 0 | None | 75 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 419 | 6 | 0 | 4 | 3.2 | O=S1(=O)Cc2ccccc2N1CCCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
90644067 | 111528 | 0 | None | 48 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 3.8 | [O-][S+](CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289383 | 111528 | 0 | None | 48 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 3.8 | [O-][S+](CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
90644060 | 111539 | 0 | None | 64 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 358 | 4 | 0 | 2 | 4.4 | Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289644 | 111539 | 0 | None | 64 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 358 | 4 | 0 | 2 | 4.4 | Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2 | 10.1016/j.bmc.2014.04.026 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00218-7 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00218-7 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00218-7 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00218-7 | ||
53363110 | 63520 | 0 | None | 4 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 507 | 14 | 0 | 8 | 4.8 | CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803050 | 63520 | 0 | None | 4 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 507 | 14 | 0 | 8 | 4.8 | CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
24936042 | 157047 | 0 | None | 1 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 380 | 8 | 0 | 6 | 3.3 | COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4080762 | 157047 | 0 | None | 1 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 380 | 8 | 0 | 6 | 3.3 | COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
6603820 | 95330 | 13 | None | -1 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL25856 | 95330 | 13 | None | -1 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | 10.1016/j.bmc.2009.08.028 | ||
11428416 | 5223 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 4.0 | CCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL106599 | 5223 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 4.0 | CCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
11406804 | 163910 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 4.7 | CCOc1cc(Cl)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL421403 | 163910 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 4.7 | CCOc1cc(Cl)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
127029386 | 138867 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccc(F)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793375 | 138867 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccc(F)cc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
11772767 | 79592 | 0 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL212784 | 79592 | 0 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(Cl)c1 | 10.1021/jm060279f | ||
164628817 | 185695 | 0 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 349 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4874069 | 185695 | 0 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 349 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 | 10.1016/j.ejmech.2021.113243 | ||
11849775 | 165643 | 0 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
CHEMBL426510 | 165643 | 0 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
44340376 | 110157 | 0 | None | 6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.9 | COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL325818 | 110157 | 0 | None | 6 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.9 | COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10476504 | 33268 | 1 | None | -1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
CHEMBL142020 | 33268 | 1 | None | -1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
44403214 | 72148 | 0 | None | -9 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 8 | 1 | 5 | 2.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL198993 | 72148 | 0 | None | -9 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 8 | 1 | 5 | 2.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
44393393 | 123156 | 0 | None | -91 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 537 | 7 | 1 | 4 | 5.0 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL362101 | 123156 | 0 | None | -91 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 537 | 7 | 1 | 4 | 5.0 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1 | 10.1016/j.bmcl.2004.05.052 | ||
44381147 | 58421 | 0 | None | -3 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL168544 | 58421 | 0 | None | -3 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
55445 | 98096 | 16 | None | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCCC(c2cccc(O)c2)C1 | 10.1021/jm00073a021 | ||
CHEMBL276500 | 98096 | 16 | None | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCCC(c2cccc(O)c2)C1 | 10.1021/jm00073a021 | ||
154724369 | 176115 | 1 | None | -3 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 12 | 0 | 6 | 6.1 | CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4584372 | 176115 | 1 | None | -3 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 12 | 0 | 6 | 6.1 | CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598389 | 176115 | 1 | None | -3 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 12 | 0 | 6 | 6.1 | CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
127031829 | 138898 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793890 | 138898 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
127028182 | 138932 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 336 | 5 | 0 | 4 | 3.2 | Fc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)n1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794158 | 138932 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 336 | 5 | 0 | 4 | 3.2 | Fc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)n1 | 10.1016/j.bmcl.2016.03.102 | ||
11370781 | 79461 | 0 | None | 14 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 325 | 6 | 0 | 6 | 2.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccnc1 | 10.1021/jm060279f | ||
CHEMBL212291 | 79461 | 0 | None | 14 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 325 | 6 | 0 | 6 | 2.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccnc1 | 10.1021/jm060279f | ||
25071066 | 111282 | 0 | None | -18 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c1Cl | 10.1021/jm5004039 | ||
CHEMBL3287390 | 111282 | 0 | None | -18 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c1Cl | 10.1021/jm5004039 | ||
56837634 | 68964 | 0 | None | -295 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1041 | 38 | 2 | 15 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928130 | 68964 | 0 | None | -295 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1041 | 38 | 2 | 15 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
118709172 | 112920 | 0 | None | -2 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 8 | 0 | 4 | 6.6 | Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318844 | 112920 | 0 | None | -2 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 8 | 0 | 4 | 6.6 | Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2014.06.079 | ||
137655029 | 158400 | 0 | None | -31 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 452 | 8 | 1 | 9 | 2.6 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4095881 | 158400 | 0 | None | -31 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 452 | 8 | 1 | 9 | 2.6 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
9995378 | 5399 | 0 | None | 25 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 307 | 4 | 0 | 4 | 4.0 | c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL107529 | 5399 | 0 | None | 25 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 307 | 4 | 0 | 4 | 4.0 | c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1 | 10.1016/s0960-894x(99)00540-5 | ||
276 | 3457 | 45 | None | -87 | 13 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/j.bmcl.2007.11.045 | ||
5312149 | 3457 | 45 | None | -87 | 13 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/j.bmcl.2007.11.045 | ||
CHEMBL431298 | 3457 | 45 | None | -87 | 13 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/j.bmcl.2007.11.045 | ||
10476504 | 33268 | 1 | None | -1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
CHEMBL142020 | 33268 | 1 | None | -1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
122189388 | 122727 | 0 | None | -25 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 483 | 7 | 0 | 8 | 3.8 | O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613874 | 122727 | 0 | None | -25 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 483 | 7 | 0 | 8 | 3.8 | O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 | 10.1016/j.bmc.2015.07.050 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
11077918 | 204868 | 0 | None | 7 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1 | 10.1021/jm015522j | ||
CHEMBL88937 | 204868 | 0 | None | 7 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1 | 10.1021/jm015522j | ||
11077918 | 204868 | 0 | None | 7 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1 | 10.1021/jm049612a | ||
CHEMBL88937 | 204868 | 0 | None | 7 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1 | 10.1021/jm049612a | ||
10021692 | 145849 | 12 | None | -1698 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 364 | 10 | 1 | 4 | 3.0 | C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL392158 | 145849 | 12 | None | -1698 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 364 | 10 | 1 | 4 | 3.0 | C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
11708363 | 71558 | 1 | None | -5 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@@H]1CCn2nccc2C1 | 10.1021/jm0503805 | ||
CHEMBL197159 | 71558 | 1 | None | -5 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@@H]1CCn2nccc2C1 | 10.1021/jm0503805 | ||
76336022 | 105898 | 0 | None | -2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115581 | 105898 | 0 | None | -2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139316 | 105898 | 0 | None | -2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
136094866 | 40718 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 423 | 3 | 2 | 5 | 5.3 | Cc1ccc2c(c1)C(NC1CC3CCC(C1)N3Cc1ccccc1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL148694 | 40718 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 423 | 3 | 2 | 5 | 5.3 | Cc1ccc2c(c1)C(NC1CC3CCC(C1)N3Cc1ccccc1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
127051516 | 140326 | 0 | None | -5 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 6 | 1 | 5 | 4.0 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819567 | 140326 | 0 | None | -5 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 6 | 1 | 5 | 4.0 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
56678599 | 66089 | 0 | None | 1 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 428 | 7 | 2 | 4 | 4.4 | O=C1CCc2ccc(OCCCCN3CCC(O)(c4ccc(Cl)cc4)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813586 | 66089 | 0 | None | 1 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 428 | 7 | 2 | 4 | 4.4 | O=C1CCc2ccc(OCCCCN3CCC(O)(c4ccc(Cl)cc4)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851900 | 66089 | 0 | None | 1 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 428 | 7 | 2 | 4 | 4.4 | O=C1CCc2ccc(OCCCCN3CCC(O)(c4ccc(Cl)cc4)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
154725001 | 176073 | 1 | None | -85 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4525624 | 176073 | 1 | None | -85 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598002 | 176073 | 1 | None | -85 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
145980875 | 166154 | 0 | None | 3 | 11 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 443 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL4282702 | 166154 | 0 | None | 3 | 11 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 443 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
127051516 | 140326 | 0 | None | -5 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 6 | 1 | 5 | 4.0 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819567 | 140326 | 0 | None | -5 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 420 | 6 | 1 | 5 | 4.0 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
71062646 | 149011 | 0 | None | -218 | 13 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 338 | 6 | 0 | 4 | 2.8 | c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 | nan | ||
CHEMBL3946661 | 149011 | 0 | None | -218 | 13 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 338 | 6 | 0 | 4 | 2.8 | c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 | nan | ||
154727713 | 175790 | 1 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 426 | 10 | 1 | 6 | 4.5 | COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4514586 | 175790 | 1 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 426 | 10 | 1 | 6 | 4.5 | COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595727 | 175790 | 1 | None | -1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 426 | 10 | 1 | 6 | 4.5 | COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
168287664 | 191056 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3cn4ccccc4n3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5196102 | 191056 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3cn4ccccc4n3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
154703922 | 175715 | 1 | None | -676 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4590211 | 175715 | 1 | None | -676 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595146 | 175715 | 1 | None | -676 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
44335972 | 109259 | 0 | None | 38 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 3.5 | CC1Cc2ccccc2N1C(=O)CN1CCN(CCc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL323022 | 109259 | 0 | None | 38 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 3.5 | CC1Cc2ccccc2N1C(=O)CN1CCN(CCc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44355355 | 23977 | 0 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 7 | 0 | 3 | 4.6 | CCCN(CCc1cccs1)[C@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
CHEMBL133938 | 23977 | 0 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 7 | 0 | 3 | 4.6 | CCCN(CCc1cccs1)[C@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
11849816 | 77725 | 0 | None | -5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(\CCN1CCC(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL210101 | 77725 | 0 | None | -5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(\CCN1CCC(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
5249956 | 73048 | 1 | None | -70 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1021/jm050846j | ||
CHEMBL201525 | 73048 | 1 | None | -70 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1021/jm050846j | ||
164611932 | 184619 | 0 | None | -33 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 364 | 6 | 1 | 4 | 3.1 | O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4857597 | 184619 | 0 | None | -33 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 364 | 6 | 1 | 4 | 3.1 | O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
168273063 | 189691 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5175728 | 189691 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
11028157 | 201033 | 0 | None | -128 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 563 | 8 | 1 | 4 | 6.3 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12 | 10.1016/j.bmcl.2003.09.083 | ||
CHEMBL61789 | 201033 | 0 | None | -128 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 563 | 8 | 1 | 4 | 6.3 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12 | 10.1016/j.bmcl.2003.09.083 | ||
10183626 | 12937 | 0 | None | -44 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 4 | 6.2 | Fc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1190010 | 12937 | 0 | None | -44 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 4 | 6.2 | Fc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL539999 | 12937 | 0 | None | -44 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 469 | 9 | 0 | 4 | 6.2 | Fc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
127052466 | 140255 | 0 | None | -8 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1Cc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818669 | 140255 | 0 | None | -8 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1Cc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
163322330 | 190106 | 3 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5182191 | 190106 | 3 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
145968810 | 164486 | 0 | None | -5 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4226226 | 164486 | 0 | None | -5 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | ||
56658006 | 66038 | 0 | None | -4 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 468 | 7 | 2 | 5 | 4.4 | O=C1CCc2ccc(OCCCCN3CCC(n4c(=O)[nH]c5cc(Cl)ccc54)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813588 | 66038 | 0 | None | -4 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 468 | 7 | 2 | 5 | 4.4 | O=C1CCc2ccc(OCCCCN3CCC(n4c(=O)[nH]c5cc(Cl)ccc54)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851643 | 66038 | 0 | None | -4 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 468 | 7 | 2 | 5 | 4.4 | O=C1CCc2ccc(OCCCCN3CCC(n4c(=O)[nH]c5cc(Cl)ccc54)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
44436300 | 148304 | 0 | None | -10 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2021.128028 | ||
CHEMBL394110 | 148304 | 0 | None | -10 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2021.128028 | ||
44438206 | 146676 | 3 | None | 3 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 3 | 3 | 3 | 3.4 | Oc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL392823 | 146676 | 3 | None | 3 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 3 | 3 | 3 | 3.4 | Oc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
44336046 | 4737 | 0 | None | 3 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 398 | 4 | 0 | 2 | 3.6 | C[C@@H]1CN(Cc2ccc(Cl)cc2)CC[N@@+]1(C)CC(=O)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104138 | 4737 | 0 | None | 3 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 398 | 4 | 0 | 2 | 3.6 | C[C@@H]1CN(Cc2ccc(Cl)cc2)CC[N@@+]1(C)CC(=O)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
127052466 | 140255 | 0 | None | -8 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1Cc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818669 | 140255 | 0 | None | -8 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1Cc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
44332701 | 4495 | 0 | None | -35 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 360 | 8 | 2 | 5 | 2.9 | CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL102490 | 4495 | 0 | None | -35 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 360 | 8 | 2 | 5 | 2.9 | CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl | 10.1016/s0960-894x(98)00014-6 | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm900095y | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm900095y | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm900095y | ||
73213196 | 103981 | 1 | None | -12 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
CHEMBL3104093 | 103981 | 1 | None | -12 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.9 | CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
44330514 | 206655 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 260 | 1 | 0 | 3 | 4.3 | Cc1sc(C)c2c1CCCc1cnn(C(C)C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL99649 | 206655 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 260 | 1 | 0 | 3 | 4.3 | Cc1sc(C)c2c1CCCc1cnn(C(C)C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
11026289 | 109046 | 0 | None | -3 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 425 | 6 | 1 | 4 | 3.8 | O=C(NCCCN1CCN(c2ccccc2)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
CHEMBL322179 | 109046 | 0 | None | -3 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 425 | 6 | 1 | 4 | 3.8 | O=C(NCCCN1CCN(c2ccccc2)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
155532148 | 171135 | 0 | None | -794 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 4.2 | COc1ccccc1N1CCN(CC2COCC(c3ccccc3)(c3ccccc3)O2)CC1 | 10.1016/j.ejmech.2019.02.056 | ||
CHEMBL4466677 | 171135 | 0 | None | -794 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 4.2 | COc1ccccc1N1CCN(CC2COCC(c3ccccc3)(c3ccccc3)O2)CC1 | 10.1016/j.ejmech.2019.02.056 | ||
CHEMBL5082465 | 213032 | 0 | None | -239 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | None | None | None | CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2CCCCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.1c00611 | ||||
44336062 | 5135 | 0 | None | 67 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL106119 | 5135 | 0 | None | 67 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
35296170 | 141808 | 4 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 358 | 5 | 1 | 2 | 4.3 | O=C(NC1CCN(CCc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL388620 | 141808 | 4 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 358 | 5 | 1 | 2 | 4.3 | O=C(NC1CCN(CCc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
49799695 | 14283 | 0 | None | -58 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 376 | 4 | 2 | 4 | 3.7 | COc1cccc2[nH]cc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173436 | 14283 | 0 | None | -58 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 376 | 4 | 2 | 4 | 3.7 | COc1cccc2[nH]cc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200285 | 14283 | 0 | None | -58 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 376 | 4 | 2 | 4 | 3.7 | COc1cccc2[nH]cc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL5090346 | 213483 | 0 | None | -11 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | None | None | None | N#CC(CCNCCc1ccccc1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
130431318 | 171817 | 2 | None | -1905 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 484 | 9 | 3 | 5 | 3.7 | CCc1cc(Cl)c(OC)c(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4476394 | 171817 | 2 | None | -1905 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 484 | 9 | 3 | 5 | 3.7 | CCc1cc(Cl)c(OC)c(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
168293190 | 191532 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 363 | 5 | 0 | 2 | 5.5 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(Cl)c(Cl)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5203595 | 191532 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 363 | 5 | 0 | 2 | 5.5 | Cc1ccc(CO[C@H]2CCCN(Cc3ccc(Cl)c(Cl)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
11036641 | 31562 | 0 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
CHEMBL140612 | 31562 | 0 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
10473658 | 186610 | 3 | None | 38 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1021/jm970021c | ||
CHEMBL49231 | 186610 | 3 | None | 38 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1021/jm970021c | ||
44330567 | 206540 | 0 | None | 29 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 272 | 0 | 0 | 3 | 3.9 | Cn1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL98946 | 206540 | 0 | None | 29 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 272 | 0 | 0 | 3 | 3.9 | Cn1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
44336036 | 4807 | 0 | None | 416 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1CN(Cc2ccc(Cl)cc2)CCN1CC(=O)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104399 | 4807 | 0 | None | 416 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1CN(Cc2ccc(Cl)cc2)CCN1CC(=O)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
9841249 | 16218 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 348 | 3 | 0 | 4 | 3.7 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1C | 10.1021/jm990266k | ||
CHEMBL123030 | 16218 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 348 | 3 | 0 | 4 | 3.7 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1C | 10.1021/jm990266k | ||
9840412 | 117594 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 6 | 2 | 4 | 3.6 | O=c1ccc2ccc(CNCCNc3ccc(Cl)cc3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL340669 | 117594 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 6 | 2 | 4 | 3.6 | O=c1ccc2ccc(CNCCNc3ccc(Cl)cc3)cc2o1 | 10.1021/jm990266k | ||
155538349 | 171810 | 0 | None | 43 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 521 | 9 | 2 | 4 | 4.9 | O=C(NCCCN1CCN(c2ccc(Br)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4476278 | 171810 | 0 | None | 43 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 521 | 9 | 2 | 4 | 4.9 | O=C(NCCCN1CCN(c2ccc(Br)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
145988180 | 164679 | 0 | None | -1 | 6 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 303 | 10 | 1 | 2 | 5.3 | CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4229178 | 164679 | 0 | None | -1 | 6 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 303 | 10 | 1 | 2 | 5.3 | CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
164628817 | 185695 | 0 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 349 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4874069 | 185695 | 0 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 349 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2 | 10.1016/j.ejmech.2021.113243 | ||
56944383 | 111627 | 0 | None | -25 | 12 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | ||
CHEMBL3290012 | 111627 | 0 | None | -25 | 12 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | ||
44405455 | 72023 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 398 | 5 | 1 | 3 | 4.7 | O=C(N[C@H]1CCN(Cc2ccc(F)c(F)c2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL198580 | 72023 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 398 | 5 | 1 | 3 | 4.7 | O=C(N[C@H]1CCN(Cc2ccc(F)c(F)c2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
44405489 | 132295 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.4 | O=C(N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL370134 | 132295 | 0 | None | 9 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.4 | O=C(N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
44405466 | 165827 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 392 | 6 | 1 | 4 | 4.4 | COc1cccc(CN2CC[C@H](NC(=O)c3ccc(-c4cccs4)cc3)C2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL427555 | 165827 | 0 | None | 1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 392 | 6 | 1 | 4 | 4.4 | COc1cccc(CN2CC[C@H](NC(=O)c3ccc(-c4cccs4)cc3)C2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
53364083 | 63523 | 0 | None | 2 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 658 | 21 | 0 | 11 | 6.2 | CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803053 | 63523 | 0 | None | 2 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 658 | 21 | 0 | 11 | 6.2 | CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
72545011 | 92694 | 0 | None | 8 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 8 | 0 | 7 | 2.9 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443004 | 92694 | 0 | None | 8 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 8 | 0 | 7 | 2.9 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
137636460 | 155579 | 0 | None | 2 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.9 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4063282 | 155579 | 0 | None | 2 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.9 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
137642380 | 157961 | 0 | None | -2 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4091155 | 157961 | 0 | None | -2 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.2 | O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1 | 10.1021/acs.jmedchem.6b01857 | ||
11036641 | 31562 | 0 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
CHEMBL140612 | 31562 | 0 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
71734029 | 90624 | 0 | None | -4 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm400520c | ||
CHEMBL2397392 | 90624 | 0 | None | -4 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm400520c | ||
45272537 | 194851 | 0 | None | 181 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 4 | 0 | 6 | 3.0 | COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL563614 | 194851 | 0 | None | 181 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 4 | 0 | 6 | 3.0 | COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
44393775 | 65972 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 4 | 1 | 4 | 4.2 | Cc1cc(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)ccc1Br | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184853 | 65972 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 4 | 1 | 4 | 4.2 | Cc1cc(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)ccc1Br | 10.1016/j.bmcl.2004.07.068 | ||
10200496 | 83180 | 0 | None | -25 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 3.6 | O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm1013693 | ||
CHEMBL2204343 | 83180 | 0 | None | -25 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 3.6 | O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm1013693 | ||
10473658 | 186610 | 3 | None | 38 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL49231 | 186610 | 3 | None | 38 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
9909055 | 4773 | 5 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 4 | 0 | 4 | 3.6 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCSc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104238 | 4773 | 5 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 4 | 0 | 4 | 3.6 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCSc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
11325334 | 79641 | 0 | None | 11 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL212969 | 79641 | 0 | None | 11 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
127031515 | 138904 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793910 | 138904 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
76314268 | 105953 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115577 | 105953 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139633 | 105953 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
18414156 | 106602 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 2.6 | Oc1nc2c(N3CCN(Cc4ccccc4)CC3)cccc2[nH]1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL315864 | 106602 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 2.6 | Oc1nc2c(N3CCN(Cc4ccccc4)CC3)cccc2[nH]1 | 10.1016/s0960-894x(98)00474-0 | ||
18414156 | 106602 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 2.6 | Oc1nc2c(N3CCN(Cc4ccccc4)CC3)cccc2[nH]1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL315864 | 106602 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 2.6 | Oc1nc2c(N3CCN(Cc4ccccc4)CC3)cccc2[nH]1 | 10.1007/s00044-012-0055-5 | ||
76314268 | 105953 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115577 | 105953 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139633 | 105953 | 0 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
11724450 | 123330 | 4 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184158 | 123330 | 4 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL362542 | 123330 | 4 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
2728532 | 111066 | 2 | None | -1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 291 | 3 | 1 | 2 | 3.5 | c1ccc(CN2CCN(c3cccc4[nH]ccc34)CC2)cc1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL328051 | 111066 | 2 | None | -1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 291 | 3 | 1 | 2 | 3.5 | c1ccc(CN2CCN(c3cccc4[nH]ccc34)CC2)cc1 | 10.1016/s0960-894x(98)00474-0 | ||
76331467 | 85458 | 0 | None | -1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 287 | 3 | 1 | 0 | 2.8 | c1ccc(C[n+]2cc[n+](-c3cccc4[nH]ccc34)cc2)cc1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL2298808 | 85458 | 0 | None | -1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 287 | 3 | 1 | 0 | 2.8 | c1ccc(C[n+]2cc[n+](-c3cccc4[nH]ccc34)cc2)cc1 | 10.1007/s00044-012-0055-5 | ||
10064981 | 203319 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
CHEMBL76982 | 203319 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
44264629 | 96917 | 0 | None | 33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL269576 | 96917 | 0 | None | 33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
44380685 | 58427 | 0 | None | 4 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 373 | 6 | 2 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL168566 | 58427 | 0 | None | 4 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 373 | 6 | 2 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
25128757 | 102829 | 0 | None | -38 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 3 | 1 | 3 | 5.6 | O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12 | 10.1021/jm800532x | ||
CHEMBL3084512 | 102829 | 0 | None | -38 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 3 | 1 | 3 | 5.6 | O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12 | 10.1021/jm800532x | ||
134154387 | 151928 | 0 | None | -2 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 289 | 3 | 0 | 1 | 4.5 | C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3970994 | 151928 | 0 | None | -2 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 289 | 3 | 0 | 1 | 4.5 | C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
164626655 | 186011 | 0 | None | -41 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4878587 | 186011 | 0 | None | -41 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
145990141 | 166226 | 0 | None | -67 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 388 | 7 | 2 | 4 | 3.6 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4283982 | 166226 | 0 | None | -67 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 388 | 7 | 2 | 4 | 3.6 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
60167309 | 74947 | 0 | None | 1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 5.3 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL2037432 | 74947 | 0 | None | 1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 5.3 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
60167309 | 74947 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 5.3 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037432 | 74947 | 0 | None | -1 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 5.3 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.ejmech.2012.03.042 | ||
11699469 | 77299 | 0 | None | -8 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 537 | 8 | 1 | 5 | 5.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1 | 10.1021/jm060138d | ||
CHEMBL208847 | 77299 | 0 | None | -8 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 537 | 8 | 1 | 5 | 5.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1 | 10.1021/jm060138d | ||
57402365 | 68953 | 0 | None | -10 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 441 | 12 | 1 | 6 | 3.1 | CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928119 | 68953 | 0 | None | -10 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 441 | 12 | 1 | 6 | 3.1 | CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/j.bmc.2011.10.063 | ||
56837635 | 68966 | 0 | None | -467 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1129 | 44 | 2 | 17 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928132 | 68966 | 0 | None | -467 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1129 | 44 | 2 | 17 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
57398875 | 68972 | 0 | None | -40 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1005 | 30 | 2 | 17 | 4.7 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928138 | 68972 | 0 | None | -40 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1005 | 30 | 2 | 17 | 4.7 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
127046950 | 139515 | 0 | None | -7 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 437 | 12 | 4 | 6 | 4.0 | COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3800303 | 139515 | 0 | None | -7 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 437 | 12 | 4 | 6 | 4.0 | COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
137643122 | 157491 | 0 | None | -17 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 467 | 8 | 2 | 10 | 2.6 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4085752 | 157491 | 0 | None | -17 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 467 | 8 | 2 | 10 | 2.6 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
44459452 | 93460 | 0 | None | 2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1cc(-c2ccccc2)n(C2CCN(Cc3ccccc3)CC2)n1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL24809 | 93460 | 0 | None | 2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1cc(-c2ccccc2)n(C2CCN(Cc3ccccc3)CC2)n1 | 10.1016/s0960-894x(99)00169-9 | ||
19964406 | 114017 | 3 | None | 75 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CCC2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335535 | 114017 | 3 | None | 75 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CCC2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
10524751 | 57056 | 0 | None | 1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 395 | 5 | 0 | 1 | 6.5 | CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1 | 10.1021/jm991098z | ||
CHEMBL165171 | 57056 | 0 | None | 1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 395 | 5 | 0 | 1 | 6.5 | CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1 | 10.1021/jm991098z | ||
10543696 | 4513 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(-c2nc(CN3CCN(c4ccncn4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
CHEMBL102599 | 4513 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(-c2nc(CN3CCN(c4ccncn4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
51354277 | 59897 | 0 | None | -1288 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 429 | 11 | 1 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(OCCF)cc2)CC1 | 10.1021/jm101323b | ||
CHEMBL1688992 | 59897 | 0 | None | -1288 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 429 | 11 | 1 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(OCCF)cc2)CC1 | 10.1021/jm101323b | ||
CHEMBL1739996 | 59897 | 0 | None | -1288 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 429 | 11 | 1 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(OCCF)cc2)CC1 | 10.1021/jm101323b | ||
145993220 | 166211 | 0 | None | -58 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 355 | 7 | 2 | 5 | 2.4 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccncc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4283709 | 166211 | 0 | None | -58 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 355 | 7 | 2 | 5 | 2.4 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccncc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
168277992 | 189535 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1cnc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5173368 | 189535 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1cnc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
25139332 | 183737 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 11 | 1 | 2 | 5.0 | CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800895v | ||
CHEMBL484204 | 183737 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 11 | 1 | 2 | 5.0 | CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800895v | ||
127045853 | 139263 | 0 | None | -5623 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 492 | 12 | 4 | 7 | 3.6 | COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3798748 | 139263 | 0 | None | -5623 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 492 | 12 | 4 | 7 | 3.6 | COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
118709168 | 112916 | 0 | None | -7 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1000 | 29 | 0 | 8 | 14.4 | O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318840 | 112916 | 0 | None | -7 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1000 | 29 | 0 | 8 | 14.4 | O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
122189389 | 122728 | 0 | None | -323 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 497 | 8 | 0 | 8 | 4.2 | O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613875 | 122728 | 0 | None | -323 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 497 | 8 | 0 | 8 | 4.2 | O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 | 10.1016/j.bmc.2015.07.050 | ||
11694483 | 71899 | 0 | None | -2 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 249 | 6 | 0 | 4 | 2.1 | CCCN(CCC)C1CCn2ncc(C=O)c2C1 | 10.1021/jm0503805 | ||
CHEMBL198174 | 71899 | 0 | None | -2 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 249 | 6 | 0 | 4 | 2.1 | CCCN(CCC)C1CCn2ncc(C=O)c2C1 | 10.1021/jm0503805 | ||
90644069 | 111546 | 0 | None | -1 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 341 | 4 | 0 | 4 | 3.8 | Clc1ccc(N2CCN(CCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289651 | 111546 | 0 | None | -1 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 341 | 4 | 0 | 4 | 3.8 | Clc1ccc(N2CCN(CCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
60165537 | 75001 | 0 | None | -1 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 308 | 5 | 0 | 3 | 4.6 | c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037523 | 75001 | 0 | None | -1 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 308 | 5 | 0 | 3 | 4.6 | c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2 | 10.1016/j.ejmech.2012.03.042 | ||
10548967 | 112234 | 0 | None | -12 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 399 | 5 | 0 | 4 | 3.2 | COc1ccc2c(c1)C(=O)N(CCN1CCN(c3ccc(Cl)cc3)CC1)CC2 | 10.1021/jm991138z | ||
CHEMBL330470 | 112234 | 0 | None | -12 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 399 | 5 | 0 | 4 | 3.2 | COc1ccc2c(c1)C(=O)N(CCN1CCN(c3ccc(Cl)cc3)CC1)CC2 | 10.1021/jm991138z | ||
134154387 | 151928 | 0 | None | -2 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 289 | 3 | 0 | 1 | 4.5 | C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3970994 | 151928 | 0 | None | -2 | 9 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 289 | 3 | 0 | 1 | 4.5 | C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
60167309 | 74947 | 0 | None | 1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 5.3 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL2037432 | 74947 | 0 | None | 1 | 7 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 5.3 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
154724650 | 175763 | 1 | None | -79 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4543870 | 175763 | 1 | None | -79 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595492 | 175763 | 1 | None | -79 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
44192200 | 193719 | 2 | None | -380 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 451 | 3 | 0 | 7 | 3.9 | Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C#N)ccc4n2)CC1)O3 | 10.1021/jm900374r | ||
CHEMBL551964 | 193719 | 2 | None | -380 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 451 | 3 | 0 | 7 | 3.9 | Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C#N)ccc4n2)CC1)O3 | 10.1021/jm900374r | ||
44396235 | 167972 | 1 | None | -91 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 281 | 6 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 | 10.1021/jm049720x | ||
CHEMBL435505 | 167972 | 1 | None | -91 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 281 | 6 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 | 10.1021/jm049720x | ||
164622973 | 185541 | 0 | None | -61 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 397 | 6 | 0 | 4 | 4.5 | CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4871868 | 185541 | 0 | None | -61 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 397 | 6 | 0 | 4 | 4.5 | CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
155564667 | 174908 | 0 | None | -154 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.3 | CCc1cccc(N2CCN(CCCCNC(=O)c3nc4sccn4c3C)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4577414 | 174908 | 0 | None | -154 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.3 | CCc1cccc(N2CCN(CCCCNC(=O)c3nc4sccn4c3C)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4444356 | 212184 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | None | None | None | Nc1ccc(CN2CCC(n3cc(Cc4ccc(Br)cc4)nn3)CC2)cc1 | 10.1016/j.bmc.2022.116851 | ||||
9926401 | 140344 | 0 | None | -2 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 301 | 5 | 0 | 2 | 4.4 | Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819556 | 140344 | 0 | None | -2 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 301 | 5 | 0 | 2 | 4.4 | Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819732 | 140344 | 0 | None | -2 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 301 | 5 | 0 | 2 | 4.4 | Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
16094676 | 230 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
8439 | 230 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
CHEMBL219182 | 230 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 10.1021/jm060662k | ||
5493357 | 205099 | 4 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 321 | 2 | 1 | 4 | 3.4 | Cc1cc(O)c2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
CHEMBL90466 | 205099 | 4 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 321 | 2 | 1 | 4 | 3.4 | Cc1cc(O)c2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
9952218 | 4812 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 4 | 0 | 3 | 3.2 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2c(F)cccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104432 | 4812 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 4 | 0 | 3 | 3.2 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2c(F)cccc21 | 10.1016/s0960-894x(02)00655-8 | ||
90644065 | 111170 | 0 | None | 1 | 4 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 355 | 5 | 0 | 4 | 4.2 | Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3286429 | 111170 | 0 | None | 1 | 4 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 355 | 5 | 0 | 4 | 4.2 | Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
12050194 | 201202 | 1 | None | 5 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 333 | 5 | 0 | 4 | 3.7 | c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL62703 | 201202 | 1 | None | 5 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 333 | 5 | 0 | 4 | 3.7 | c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
9926401 | 140344 | 0 | None | -2 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 301 | 5 | 0 | 2 | 4.4 | Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819556 | 140344 | 0 | None | -2 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 301 | 5 | 0 | 2 | 4.4 | Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819732 | 140344 | 0 | None | -2 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 301 | 5 | 0 | 2 | 4.4 | Fc1ccc(SCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
71061709 | 148995 | 0 | None | 3 | 12 | Mouse | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 372 | 6 | 0 | 4 | 3.5 | Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL3946540 | 148995 | 0 | None | 3 | 12 | Mouse | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 372 | 6 | 0 | 4 | 3.5 | Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
164611932 | 184619 | 0 | None | -33 | 7 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 364 | 6 | 1 | 4 | 3.1 | O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4857597 | 184619 | 0 | None | -33 | 7 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 364 | 6 | 1 | 4 | 3.1 | O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
44427842 | 149276 | 0 | None | -9 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 494 | 7 | 1 | 4 | 5.2 | O=C(NC[C@H]1C[C@H]1CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1 | 10.1021/jm0704200 | ||
CHEMBL394863 | 149276 | 0 | None | -9 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 494 | 7 | 1 | 4 | 5.2 | O=C(NC[C@H]1C[C@H]1CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1 | 10.1021/jm0704200 | ||
49862238 | 14839 | 13 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 367 | 6 | 0 | 5 | 3.6 | COc1cccc(F)c1OC1CN(Cc2cnn(-c3ccccc3)c2C)C1 | 10.1016/j.bmcl.2010.06.033 | ||
CHEMBL1209158 | 14839 | 13 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 367 | 6 | 0 | 5 | 3.6 | COc1cccc(F)c1OC1CN(Cc2cnn(-c3ccccc3)c2C)C1 | 10.1016/j.bmcl.2010.06.033 | ||
5249956 | 73048 | 1 | None | -70 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1039/C5MD00258C | ||
CHEMBL201525 | 73048 | 1 | None | -70 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1039/C5MD00258C | ||
44278111 | 99670 | 0 | None | 13 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 368 | 4 | 1 | 3 | 4.6 | c1ccc(-c2ccc(N3CCN(Cc4c[nH]c5ncccc45)CC3)cc2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL287671 | 99670 | 0 | None | 13 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 368 | 4 | 1 | 3 | 4.6 | c1ccc(-c2ccc(N3CCN(Cc4c[nH]c5ncccc45)CC3)cc2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
11957566 | 183 | 20 | None | -79 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | 10.1016/S0960-894X(97)10068-3 | ||
1219 | 183 | 20 | None | -79 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | 10.1016/S0960-894X(97)10068-3 | ||
3296 | 183 | 20 | None | -79 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | 10.1016/S0960-894X(97)10068-3 | ||
950 | 183 | 20 | None | -79 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | 10.1016/S0960-894X(97)10068-3 | ||
CHEMBL285755 | 183 | 20 | None | -79 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | 10.1016/S0960-894X(97)10068-3 | ||
168269421 | 189369 | 0 | None | 6 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 5.3 | Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5170670 | 189369 | 0 | None | 6 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 5.3 | Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
53248212 | 61704 | 0 | None | -154 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 424 | 8 | 2 | 4 | 3.5 | COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm200288r | ||
CHEMBL1774534 | 61704 | 0 | None | -154 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 424 | 8 | 2 | 4 | 3.5 | COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm200288r | ||
44427831 | 91807 | 0 | None | -338 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 460 | 9 | 2 | 6 | 3.1 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1 | 10.1021/jm0704200 | ||
CHEMBL242644 | 91807 | 0 | None | -338 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 460 | 9 | 2 | 6 | 3.1 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1 | 10.1021/jm0704200 | ||
44438209 | 153428 | 0 | None | -9 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 406 | 9 | 2 | 3 | 5.6 | CCCCCCOc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL398368 | 153428 | 0 | None | -9 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 406 | 9 | 2 | 3 | 5.6 | CCCCCCOc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
9888555 | 165052 | 11 | None | -208 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm025558r | ||
CHEMBL424294 | 165052 | 11 | None | -208 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm025558r | ||
10642239 | 186077 | 1 | None | 53 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
CHEMBL48819 | 186077 | 1 | None | 53 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.01.044 | ||
44335907 | 5307 | 0 | None | 14 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(Cl)cc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107020 | 5307 | 0 | None | 14 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(Cl)cc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335800 | 109558 | 0 | None | 138 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 379 | 5 | 0 | 4 | 2.8 | COc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL323525 | 109558 | 0 | None | 138 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 379 | 5 | 0 | 4 | 2.8 | COc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
155537361 | 171732 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 10 | 2 | 5 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4475042 | 171732 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 10 | 2 | 5 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(Cl)cc2Cl)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
155542182 | 172539 | 0 | None | 10 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 516 | 10 | 2 | 6 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(C#N)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4520460 | 172539 | 0 | None | 10 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 516 | 10 | 2 | 6 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(C#N)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
71449737 | 81413 | 0 | None | -6 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 468 | 7 | 0 | 7 | 3.5 | COc1ccccc1N1CCN(CCN(C(=O)c2cnc3ccccc3n2)c2ccccn2)CC1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164349 | 81413 | 0 | None | -6 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 468 | 7 | 0 | 7 | 3.5 | COc1ccccc1N1CCN(CCN(C(=O)c2cnc3ccccc3n2)c2ccccn2)CC1 | 10.1016/j.bmcl.2012.05.119 | ||
44405452 | 72211 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.7 | O=C(N[C@H]1CCN(Cc2ccc(Cl)c(Cl)c2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL199186 | 72211 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.7 | O=C(N[C@H]1CCN(Cc2ccc(Cl)c(Cl)c2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
53361301 | 63511 | 0 | None | 2 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 985 | 29 | 0 | 16 | 8.6 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803024 | 63511 | 0 | None | 2 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 985 | 29 | 0 | 16 | 8.6 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
21219154 | 88135 | 0 | None | 33 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 4.4 | c1ccc(CN2CCC(n3nccc3-c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL23537 | 88135 | 0 | None | 33 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 4.4 | c1ccc(CN2CCC(n3nccc3-c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
56926587 | 68668 | 0 | None | 380 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 329 | 3 | 0 | 5 | 2.3 | Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1 | 10.1021/jm200762g | ||
CHEMBL1923416 | 68668 | 0 | None | 380 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 329 | 3 | 0 | 5 | 2.3 | Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1 | 10.1021/jm200762g | ||
53361301 | 63511 | 0 | None | 2 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 985 | 29 | 0 | 16 | 8.6 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2009919 | ||
CHEMBL1803024 | 63511 | 0 | None | 2 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 985 | 29 | 0 | 16 | 8.6 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2009919 | ||
10642239 | 186077 | 1 | None | 53 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL48819 | 186077 | 1 | None | 53 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
10642239 | 186077 | 1 | None | 53 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL48819 | 186077 | 1 | None | 53 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
9888555 | 165052 | 11 | None | -208 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm0611152 | ||
CHEMBL424294 | 165052 | 11 | None | -208 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm0611152 | ||
9861786 | 111853 | 0 | None | -19 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 317 | 6 | 3 | 4 | 3.1 | Oc1nc2c(OCCNCc3ccccc3)cc(Cl)cc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL329398 | 111853 | 0 | None | -19 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 317 | 6 | 3 | 4 | 3.1 | Oc1nc2c(OCCNCc3ccccc3)cc(Cl)cc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
44273855 | 74053 | 0 | None | 10 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.4 | COc1cc(Cl)ccc1N1CCN(CCCCNC(=O)C(C)(C)C)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20251 | 74053 | 0 | None | 10 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.4 | COc1cc(Cl)ccc1N1CCN(CCCCNC(=O)C(C)(C)C)CC1 | 10.1016/0960-894X(96)00198-9 | ||
44273928 | 77727 | 0 | None | 63 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.8 | CCC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21011 | 77727 | 0 | None | 63 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.8 | CCC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
10665101 | 101055 | 0 | None | 22 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL298166 | 101055 | 0 | None | 22 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
10413085 | 82777 | 0 | None | -64 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 484 | 8 | 2 | 4 | 4.3 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(Br)ccc3[nH]2)CC1 | 10.1021/jm0611152 | ||
CHEMBL218444 | 82777 | 0 | None | -64 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 484 | 8 | 2 | 4 | 4.3 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(Br)ccc3[nH]2)CC1 | 10.1021/jm0611152 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00200-1 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00200-1 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00200-1 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00200-1 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00200-1 | ||
127032383 | 138873 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3ccc4[nH]ccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793438 | 138873 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3ccc4[nH]ccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
10852461 | 205235 | 2 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 310 | 4 | 2 | 3 | 2.9 | O=C(Nc1ccccn1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL91272 | 205235 | 2 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 310 | 4 | 2 | 3 | 2.9 | O=C(Nc1ccccn1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
10449136 | 205698 | 0 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL94067 | 205698 | 0 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
10053476 | 116246 | 0 | None | -275 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 559 | 7 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1 | 10.1021/jm025558r | ||
CHEMBL337531 | 116246 | 0 | None | -275 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 559 | 7 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1 | 10.1021/jm025558r | ||
44380802 | 161142 | 0 | None | 1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL413343 | 161142 | 0 | None | 1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
127053220 | 138837 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.2 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793062 | 138837 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 319 | 5 | 0 | 3 | 3.2 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2016.03.102 | ||
11849821 | 168734 | 0 | None | 2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(/c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL441529 | 168734 | 0 | None | 2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | CO/N=C(/c1ccc(Cl)cc1)C(O)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
145991769 | 166328 | 0 | None | -12 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 8 | 2 | 5 | 3.0 | COc1cccc(C(=O)NCCCCN2CCc3cc(OC)c(O)cc3C2)c1 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4285984 | 166328 | 0 | None | -12 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 8 | 2 | 5 | 3.0 | COc1cccc(C(=O)NCCCCN2CCc3cc(OC)c(O)cc3C2)c1 | 10.1021/acsmedchemlett.8b00229 | ||
10476504 | 33268 | 1 | None | -1 | 7 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1016/j.bmc.2017.04.036 | ||
CHEMBL142020 | 33268 | 1 | None | -1 | 7 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1016/j.bmc.2017.04.036 | ||
72545007 | 92690 | 0 | None | 3 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 407 | 12 | 0 | 8 | 1.6 | COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443000 | 92690 | 0 | None | 3 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 407 | 12 | 0 | 8 | 1.6 | COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
71456214 | 78276 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 450 | 8 | 1 | 4 | 4.7 | CCCNC(=O)c1cc(C)c(OCC2CN(Cc3ccc(Cl)cc3)CCO2)cc1Cl | 10.1021/jm031111m | ||
CHEMBL2112466 | 78276 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 450 | 8 | 1 | 4 | 4.7 | CCCNC(=O)c1cc(C)c(OCC2CN(Cc3ccc(Cl)cc3)CCO2)cc1Cl | 10.1021/jm031111m | ||
71457956 | 78015 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.1 | COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL2111527 | 78015 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.1 | COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
71454405 | 78016 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 471 | 8 | 1 | 5 | 5.2 | COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL2111528 | 78016 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 471 | 8 | 1 | 5 | 5.2 | COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
44340415 | 8492 | 0 | None | 1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 460 | 5 | 1 | 3 | 5.3 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL109472 | 8492 | 0 | None | 1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 460 | 5 | 1 | 3 | 5.3 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
72205044 | 91513 | 0 | None | -4 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 410 | 8 | 0 | 5 | 4.3 | Clc1ccc(-n2cc(COCCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL2414355 | 91513 | 0 | None | -4 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 410 | 8 | 0 | 5 | 4.3 | Clc1ccc(-n2cc(COCCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
145979897 | 166053 | 0 | None | -151 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 480 | 7 | 2 | 4 | 3.6 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4280542 | 166053 | 0 | None | -151 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 480 | 7 | 2 | 4 | 3.6 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
15508243 | 5231 | 20 | None | 1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 366 | 3 | 0 | 2 | 3.9 | Ic1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL106635 | 5231 | 20 | None | 1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 366 | 3 | 0 | 2 | 3.9 | Ic1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
10682854 | 24432 | 1 | None | -2 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)[C@@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
CHEMBL134326 | 24432 | 1 | None | -2 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)[C@@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
44419056 | 82764 | 0 | None | -398 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.2 | C#Cc1ccc2cc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)sc2c1 | 10.1021/jm0611152 | ||
CHEMBL218368 | 82764 | 0 | None | -398 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.2 | C#Cc1ccc2cc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)sc2c1 | 10.1021/jm0611152 | ||
9930722 | 201977 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL67414 | 201977 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
9930722 | 201977 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL67414 | 201977 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(02)01056-9 | ||
127050632 | 140212 | 0 | None | -87 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.7 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818124 | 140212 | 0 | None | -87 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.7 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
168282745 | 190501 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5187721 | 190501 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
12581156 | 24946 | 15 | None | -8 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 205 | 3 | 1 | 2 | 2.2 | CCNC1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
CHEMBL134759 | 24946 | 15 | None | -8 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 205 | 3 | 1 | 2 | 2.2 | CCNC1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
72164183 | 91719 | 0 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 274 | 3 | 1 | 4 | 2.8 | Oc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420778 | 91719 | 0 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 274 | 3 | 1 | 4 | 2.8 | Oc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
133633 | 2210 | 46 | None | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmcl.2006.10.076 | ||
177 | 2210 | 46 | None | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL445102 | 2210 | 46 | None | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmcl.2006.10.076 | ||
155195311 | 173775 | 0 | None | -208 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4551160 | 173775 | 0 | None | -208 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
133633 | 2210 | 46 | None | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.12.054 | ||
177 | 2210 | 46 | None | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL445102 | 2210 | 46 | None | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.12.054 | ||
44438235 | 93225 | 2 | None | -2 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 353 | 4 | 1 | 4 | 4.6 | CSc1ccc(C2(O)CCN(Cc3coc4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246854 | 93225 | 2 | None | -2 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 353 | 4 | 1 | 4 | 4.6 | CSc1ccc(C2(O)CCN(Cc3coc4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
42626381 | 55952 | 0 | None | -645 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 452 | 9 | 3 | 6 | 2.5 | COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1021/jm900095y | ||
CHEMBL1627315 | 55952 | 0 | None | -645 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 452 | 9 | 3 | 6 | 2.5 | COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1021/jm900095y | ||
44431473 | 150206 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccccc1CN1CCC(NC(=O)c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL395632 | 150206 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccccc1CN1CCC(NC(=O)c2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2006.12.106 | ||
44438197 | 152738 | 2 | None | -58 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 374 | 3 | 2 | 2 | 5.0 | OC1(c2cccc(Cl)c2Cl)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL397770 | 152738 | 2 | None | -58 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 374 | 3 | 2 | 2 | 5.0 | OC1(c2cccc(Cl)c2Cl)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
44304814 | 201183 | 0 | None | -2 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 505 | 8 | 1 | 5 | 5.9 | COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL62601 | 201183 | 0 | None | -2 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 505 | 8 | 1 | 5 | 5.9 | COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(00)00405-4 | ||
44330564 | 106898 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 300 | 1 | 0 | 3 | 5.0 | CC(C)n1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL317825 | 106898 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 300 | 1 | 0 | 3 | 5.0 | CC(C)n1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
44336057 | 5831 | 0 | None | 2 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 437 | 4 | 0 | 3 | 4.8 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2CC12CCCCC2 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107962 | 5831 | 0 | None | 2 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 437 | 4 | 0 | 3 | 4.8 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2CC12CCCCC2 | 10.1016/s0960-894x(02)00655-8 | ||
168297637 | 191725 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3ncc4ccccn34)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5206427 | 191725 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 4.3 | Fc1cc(COC2CCN(Cc3ncc4ccccn34)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
9801858 | 63116 | 0 | None | -23 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CCC2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | ||
CHEMBL179757 | 63116 | 0 | None | -23 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CCC2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | ||
9817612 | 106772 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 4.7 | Cc1sc(C)c2c1CCCc1cnn(-c3ccccc3)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL316942 | 106772 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 4.7 | Cc1sc(C)c2c1CCCc1cnn(-c3ccccc3)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
44273876 | 79405 | 0 | None | 2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 371 | 7 | 1 | 3 | 3.7 | O=C(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21205 | 79405 | 0 | None | 2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 371 | 7 | 1 | 3 | 3.7 | O=C(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/0960-894X(96)00198-9 | ||
44517726 | 194348 | 0 | None | -63 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 341 | 4 | 0 | 2 | 3.6 | O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1 | 10.1016/j.bmcl.2009.07.055 | ||
CHEMBL560177 | 194348 | 0 | None | -63 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 341 | 4 | 0 | 2 | 3.6 | O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1 | 10.1016/j.bmcl.2009.07.055 | ||
164622973 | 185541 | 0 | None | -61 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 397 | 6 | 0 | 4 | 4.5 | CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4871868 | 185541 | 0 | None | -61 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 397 | 6 | 0 | 4 | 4.5 | CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
127051015 | 140343 | 0 | None | -5 | 9 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818128 | 140343 | 0 | None | -5 | 9 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819731 | 140343 | 0 | None | -5 | 9 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
11576528 | 83904 | 0 | None | -32 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 476 | 11 | 1 | 7 | 3.4 | COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1 | 10.1021/jm0611152 | ||
CHEMBL221587 | 83904 | 0 | None | -32 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 476 | 11 | 1 | 7 | 3.4 | COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1 | 10.1021/jm0611152 | ||
9952528 | 98979 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 5 | 1 | 3 | 3.8 | NC(=O)C1CCC(CN2CCC(=C(c3ccccc3)c3ccc(F)cc3)CC2)O1 | 10.1016/s0960-894x(01)00200-1 | ||
CHEMBL282927 | 98979 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 5 | 1 | 3 | 3.8 | NC(=O)C1CCC(CN2CCC(=C(c3ccccc3)c3ccc(F)cc3)CC2)O1 | 10.1016/s0960-894x(01)00200-1 | ||
11191906 | 11662 | 0 | None | -31 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 537 | 12 | 1 | 3 | 7.3 | O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 | 10.1016/j.bmcl.2005.06.024 | ||
CHEMBL1181665 | 11662 | 0 | None | -31 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 537 | 12 | 1 | 3 | 7.3 | O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 | 10.1016/j.bmcl.2005.06.024 | ||
CHEMBL187928 | 11662 | 0 | None | -31 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 537 | 12 | 1 | 3 | 7.3 | O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1 | 10.1016/j.bmcl.2005.06.024 | ||
127050632 | 140212 | 0 | None | -87 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.7 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818124 | 140212 | 0 | None | -87 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.7 | O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.06.011 | ||
126534204 | 137903 | 0 | None | -1412 | 5 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 504 | 7 | 1 | 7 | 3.9 | Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cc[nH]c(=O)c1 | 10.1016/j.bmc.2016.02.031 | ||
CHEMBL3774411 | 137903 | 0 | None | -1412 | 5 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 504 | 7 | 1 | 7 | 3.9 | Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cc[nH]c(=O)c1 | 10.1016/j.bmc.2016.02.031 | ||
154705884 | 175789 | 1 | None | -48 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4469584 | 175789 | 1 | None | -48 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595726 | 175789 | 1 | None | -48 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
71658072 | 89967 | 0 | None | -18 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 399 | 8 | 1 | 4 | 3.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386611 | 89967 | 0 | None | -18 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 399 | 8 | 1 | 4 | 3.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
44374431 | 54667 | 0 | None | -6 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 261 | 4 | 1 | 3 | 2.9 | CCCN[C@@H]1CCc2c(C(=O)OC)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
CHEMBL161507 | 54667 | 0 | None | -6 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 261 | 4 | 1 | 3 | 2.9 | CCCN[C@@H]1CCc2c(C(=O)OC)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970170v | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970170v | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970170v | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970170v | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970170v | ||
10665626 | 112080 | 0 | None | 41 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 4 | 0 | 5 | 3.4 | COc1ccc2c3c(c(=O)oc2c1OC)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
CHEMBL330100 | 112080 | 0 | None | 41 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 4 | 0 | 5 | 3.4 | COc1ccc2c3c(c(=O)oc2c1OC)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00316-5 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00316-5 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00316-5 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00316-5 | ||
16104 | 161368 | 15 | None | -1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL415300 | 161368 | 15 | None | -1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm00043a008 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm015522j | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm015522j | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm015522j | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm015522j | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm015522j | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00692-1 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00692-1 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00692-1 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00692-1 | ||
5311189 | 203133 | 4 | None | -1 | 27 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL7549 | 203133 | 4 | None | -1 | 27 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | 10.1016/s0960-894x(02)00390-6 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00302-9 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00302-9 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00302-9 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00302-9 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970422s | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970422s | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970422s | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970422s | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm970422s | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
9906071 | 16131 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 342 | 6 | 2 | 4 | 4.0 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1Cl | 10.1021/jm990266k | ||
CHEMBL122597 | 16131 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 342 | 6 | 2 | 4 | 4.0 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1Cl | 10.1021/jm990266k | ||
10854185 | 114041 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccccc1N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1 | 10.1021/jm990266k | ||
CHEMBL333658 | 114041 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccccc1N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1 | 10.1021/jm990266k | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0009989 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0009989 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0009989 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0009989 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0009989 | ||
155518026 | 169670 | 0 | None | 10 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 528 | 11 | 2 | 7 | 4.0 | COc1ccc(N(Cc2ccc(C#N)cc2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4445706 | 169670 | 0 | None | 10 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 528 | 11 | 2 | 7 | 4.0 | COc1ccc(N(Cc2ccc(C#N)cc2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
162653993 | 183086 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4753809 | 183086 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4802865 | 183086 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
3251 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.ejmech.2011.06.023 | ||
5684 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.ejmech.2011.06.023 | ||
80 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.ejmech.2011.06.023 | ||
CHEMBL31354 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.ejmech.2011.06.023 | ||
127052487 | 140269 | 0 | None | 3 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818805 | 140269 | 0 | None | 3 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | ||
25070740 | 111283 | 0 | None | -1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3cccn4nccc34)CC2)c1Cl | 10.1021/jm5004039 | ||
CHEMBL3287391 | 111283 | 0 | None | -1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3cccn4nccc34)CC2)c1Cl | 10.1021/jm5004039 | ||
25072943 | 111285 | 0 | None | -2 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3cccc4ccnn34)CC2)c1Cl | 10.1021/jm5004039 | ||
CHEMBL3287393 | 111285 | 0 | None | -2 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3cccc4ccnn34)CC2)c1Cl | 10.1021/jm5004039 | ||
44431486 | 87645 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1cccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234645 | 87645 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1cccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
44405469 | 71642 | 0 | None | 14 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 396 | 5 | 1 | 3 | 5.1 | O=C(N[C@H]1CCN(Cc2ccc(Cl)cc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL197381 | 71642 | 0 | None | 14 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 396 | 5 | 1 | 3 | 5.1 | O=C(N[C@H]1CCN(Cc2ccc(Cl)cc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
72545240 | 92697 | 0 | None | 16 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 469 | 12 | 0 | 8 | 3.4 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443007 | 92697 | 0 | None | 16 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 469 | 12 | 0 | 8 | 3.4 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00540-5 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00540-5 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00540-5 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(99)00540-5 | ||
44436602 | 144680 | 0 | None | -2 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 8 | 1 | 4 | 3.0 | C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL391256 | 144680 | 0 | None | -2 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 8 | 1 | 4 | 3.0 | C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm901120h | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm901120h | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm901120h | ||
122181329 | 121356 | 0 | None | -51 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 394 | 10 | 1 | 2 | 4.6 | CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590080 | 121356 | 0 | None | -51 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 394 | 10 | 1 | 2 | 4.6 | CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
71459759 | 83657 | 0 | None | 4 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 4 | 0 | 3 | 5.5 | COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207633 | 83657 | 0 | None | 4 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 4 | 0 | 3 | 5.5 | COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm060166w | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm060166w | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm060166w | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm060166w | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm060166w | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2009.05.015 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2009.05.015 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2009.05.015 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2009.05.015 | ||
45269168 | 194256 | 0 | None | 10 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 1 | 6 | 2.3 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL559399 | 194256 | 0 | None | 10 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 4 | 1 | 6 | 2.3 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00814-9 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00814-9 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00814-9 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(01)00814-9 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00405-4 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00405-4 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00405-4 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00405-4 | ||
3251 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | ||
5684 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | ||
80 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | ||
CHEMBL31354 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1021/jm1009956 | ||
127031519 | 138793 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.7 | CSc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792638 | 138793 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 329 | 6 | 0 | 4 | 3.7 | CSc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127053221 | 138801 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792728 | 138801 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
127052487 | 140269 | 0 | None | 3 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818805 | 140269 | 0 | None | 3 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 5.1 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2016.06.011 | ||
10612157 | 101387 | 1 | None | -15 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 271 | 4 | 2 | 4 | 2.3 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CO2 | 10.1021/jm9703653 | ||
CHEMBL300571 | 101387 | 1 | None | -15 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 271 | 4 | 2 | 4 | 2.3 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CO2 | 10.1021/jm9703653 | ||
CHEMBL423890 | 101387 | 1 | None | -15 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 271 | 4 | 2 | 4 | 2.3 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CO2 | 10.1021/jm9703653 | ||
10612157 | 101387 | 1 | None | -15 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 271 | 4 | 2 | 4 | 2.3 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CO2 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL300571 | 101387 | 1 | None | -15 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 271 | 4 | 2 | 4 | 2.3 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CO2 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL423890 | 101387 | 1 | None | -15 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 271 | 4 | 2 | 4 | 2.3 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CO2 | 10.1016/s0960-894x(98)00014-6 | ||
162653993 | 183086 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4753809 | 183086 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4802865 | 183086 | 0 | None | 1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
3645619 | 2985 | 13 | None | -4 | 9 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/j.bmcl.2005.02.012 | ||
975 | 2985 | 13 | None | -4 | 9 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL45244 | 2985 | 13 | None | -4 | 9 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/j.bmcl.2005.02.012 | ||
9982854 | 83923 | 0 | None | -24 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 485 | 8 | 1 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(Br)ccc3o2)CC1 | 10.1021/jm0611152 | ||
CHEMBL221681 | 83923 | 0 | None | -24 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 485 | 8 | 1 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(Br)ccc3o2)CC1 | 10.1021/jm0611152 | ||
10687967 | 203343 | 0 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 331 | 5 | 1 | 2 | 4.4 | c1ccc(Cc2cc(C3CCN(Cc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL77148 | 203343 | 0 | None | 1 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 331 | 5 | 1 | 2 | 4.4 | c1ccc(Cc2cc(C3CCN(Cc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10039198 | 56055 | 0 | None | -4 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
CHEMBL163087 | 56055 | 0 | None | -4 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
15467372 | 168544 | 0 | None | 43 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 317 | 4 | 1 | 4 | 2.8 | N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL440120 | 168544 | 0 | None | 43 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 317 | 4 | 1 | 4 | 2.8 | N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1 | 10.1016/s0960-894x(99)00302-9 | ||
127032082 | 138787 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3cn4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792541 | 138787 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3cn4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127051015 | 140343 | 0 | None | -5 | 9 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818128 | 140343 | 0 | None | -5 | 9 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819731 | 140343 | 0 | None | -5 | 9 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
137635364 | 155719 | 0 | None | -512 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 439 | 10 | 1 | 6 | 3.0 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 | 10.1016/j.bmc.2017.04.036 | ||
CHEMBL4064974 | 155719 | 0 | None | -512 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 439 | 10 | 1 | 6 | 3.0 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 | 10.1016/j.bmc.2017.04.036 | ||
CHEMBL4074669 | 155719 | 0 | None | -512 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 439 | 10 | 1 | 6 | 3.0 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 | 10.1016/j.bmc.2017.04.036 | ||
57391896 | 68963 | 0 | None | -24 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1013 | 36 | 2 | 15 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928129 | 68963 | 0 | None | -24 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1013 | 36 | 2 | 15 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
57400557 | 68970 | 0 | None | -131 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 509 | 14 | 1 | 8 | 3.2 | CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928136 | 68970 | 0 | None | -131 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 509 | 14 | 1 | 8 | 3.2 | CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
118709170 | 112918 | 0 | None | -6 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1057 | 33 | 0 | 8 | 16.0 | O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318842 | 112918 | 0 | None | -6 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1057 | 33 | 0 | 8 | 16.0 | O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
137645830 | 157310 | 0 | None | -3 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 424 | 7 | 1 | 8 | 2.8 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4083727 | 157310 | 0 | None | -3 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 424 | 7 | 1 | 8 | 2.8 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 | 10.1021/acs.jmedchem.7b00363 | ||
10924369 | 9246 | 1 | None | -1000 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 3.1 | COc1cccc2c1N1CCN(C)C[C@@H]1c1ccccc1C2 | 10.1021/jm010566d | ||
CHEMBL111184 | 9246 | 1 | None | -1000 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 3.1 | COc1cccc2c1N1CCN(C)C[C@@H]1c1ccccc1C2 | 10.1021/jm010566d | ||
11747350 | 106848 | 0 | None | -79 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.4 | CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C | 10.1021/jm010943m | ||
CHEMBL317535 | 106848 | 0 | None | -79 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.4 | CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C | 10.1021/jm010943m | ||
2337 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
50 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
5002 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
CHEMBL716 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
DB01224 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
2337 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
50 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
5002 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
CHEMBL716 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
DB01224 | 3205 | 72 | None | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
CHEMBL5075726 | 212624 | 0 | None | -30 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2CCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/acs.jmedchem.1c00611 | ||||
44335635 | 4728 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1cc(Cl)ccc1OC[C@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104099 | 4728 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1cc(Cl)ccc1OC[C@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
44381217 | 58834 | 0 | None | 4 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 442 | 5 | 1 | 5 | 3.4 | COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL169889 | 58834 | 0 | None | 4 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 442 | 5 | 1 | 5 | 3.4 | COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
44319368 | 105584 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 429 | 5 | 0 | 5 | 3.4 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL313320 | 105584 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 429 | 5 | 0 | 5 | 3.4 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1 | 10.1016/s0960-894x(01)00484-x | ||
11356479 | 71493 | 0 | None | -8 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)C1CCn2nccc2C1 | 10.1021/jm0503805 | ||
CHEMBL196928 | 71493 | 0 | None | -8 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)C1CCn2nccc2C1 | 10.1021/jm0503805 | ||
10564794 | 57235 | 0 | None | -4 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 281 | 5 | 0 | 1 | 4.6 | CCCN(CCC)C1CC=C(C#Cc2ccccc2)CC1 | 10.1021/jm991098z | ||
CHEMBL166325 | 57235 | 0 | None | -4 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 281 | 5 | 0 | 1 | 4.6 | CCCN(CCC)C1CC=C(C#Cc2ccccc2)CC1 | 10.1021/jm991098z | ||
11615782 | 71882 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 251 | 6 | 1 | 4 | 1.8 | CCCN(CCC)C1CCn2ncc(CO)c2C1 | 10.1021/jm0503805 | ||
CHEMBL198125 | 71882 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 251 | 6 | 1 | 4 | 1.8 | CCCN(CCC)C1CCn2ncc(CO)c2C1 | 10.1021/jm0503805 | ||
154704368 | 175897 | 1 | None | -35 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4569006 | 175897 | 1 | None | -35 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596571 | 175897 | 1 | None | -35 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
135469096 | 11961 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 6 | 1 | 7 | 2.1 | c1cnc(N2CCN(CCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1183656 | 11961 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 6 | 1 | 7 | 2.1 | c1cnc(N2CCN(CCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL309843 | 11961 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 6 | 1 | 7 | 2.1 | c1cnc(N2CCN(CCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
71658074 | 89969 | 0 | None | -64 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 420 | 8 | 2 | 4 | 3.9 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386613 | 89969 | 0 | None | -64 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 420 | 8 | 2 | 4 | 3.9 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
76325764 | 105819 | 0 | None | -37 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 434 | 8 | 2 | 5 | 3.3 | COc1ccc2[nH]c(C(=O)NC/C=C/CN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1039/c3md00098b | ||
CHEMBL3133866 | 105819 | 0 | None | -37 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 434 | 8 | 2 | 5 | 3.3 | COc1ccc2[nH]c(C(=O)NC/C=C/CN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1039/c3md00098b | ||
CHEMBL3139064 | 105819 | 0 | None | -37 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 434 | 8 | 2 | 5 | 3.3 | COc1ccc2[nH]c(C(=O)NC/C=C/CN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1039/c3md00098b | ||
60167452 | 75004 | 0 | None | -9 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 4.1 | O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL2037526 | 75004 | 0 | None | -9 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 4.1 | O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
60167452 | 75004 | 0 | None | -9 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 4.1 | O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037526 | 75004 | 0 | None | -9 | 8 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 4.1 | O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
4064333 | 85313 | 17 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
4064333 | 85313 | 17 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL229019 | 85313 | 17 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229019 | 85313 | 17 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(NC1CCN(Cc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
3038495 | 700 | 30 | None | -109 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm049031l | ||
7625 | 700 | 30 | None | -109 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm049031l | ||
CHEMBL25236 | 700 | 30 | None | -109 | 19 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm049031l | ||
60167452 | 75004 | 0 | None | -9 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 4.1 | O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL2037526 | 75004 | 0 | None | -9 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 7 | 1 | 6 | 4.1 | O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
127051016 | 140345 | 0 | None | -5 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819642 | 140345 | 0 | None | -5 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819734 | 140345 | 0 | None | -5 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
49798839 | 14247 | 0 | None | -53 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 347 | 3 | 1 | 4 | 3.9 | O=c1[nH]c2ccccc2n1C1CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1172214 | 14247 | 0 | None | -53 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 347 | 3 | 1 | 4 | 3.9 | O=c1[nH]c2ccccc2n1C1CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200154 | 14247 | 0 | None | -53 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 347 | 3 | 1 | 4 | 3.9 | O=c1[nH]c2ccccc2n1C1CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
154703438 | 175807 | 1 | None | -6 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 12 | 0 | 6 | 6.1 | COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4475699 | 175807 | 1 | None | -6 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 12 | 0 | 6 | 6.1 | COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595859 | 175807 | 1 | None | -6 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 12 | 0 | 6 | 6.1 | COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | ||
127051016 | 140345 | 0 | None | -5 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819642 | 140345 | 0 | None | -5 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819734 | 140345 | 0 | None | -5 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 386 | 5 | 1 | 4 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
118719799 | 115226 | 0 | None | -25 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 487 | 10 | 0 | 7 | 5.5 | COc1ccccc1N1CCN(CCCCCc2cn(-c3ccc(-c4ccsc4)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353902 | 115226 | 0 | None | -25 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 487 | 10 | 0 | 7 | 5.5 | COc1ccccc1N1CCN(CCCCCc2cn(-c3ccc(-c4ccsc4)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
10893228 | 39974 | 0 | None | 117 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 341 | 0 | 1 | 5 | 3.5 | CN1CCCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm0104825 | ||
CHEMBL148042 | 39974 | 0 | None | 117 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 341 | 0 | 1 | 5 | 3.5 | CN1CCCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm0104825 | ||
145970938 | 164604 | 0 | None | -1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 233 | 5 | 1 | 2 | 3.4 | CCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4228054 | 164604 | 0 | None | -1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 233 | 5 | 1 | 2 | 3.4 | CCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
145992489 | 166424 | 0 | None | -5 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 535 | 7 | 1 | 2 | 7.8 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL4287623 | 166424 | 0 | None | -5 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 535 | 7 | 1 | 2 | 7.8 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
9992499 | 73039 | 0 | None | -6 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 254 | 0 | 0 | 2 | 2.6 | CN1CCc2ccccc2Cc2ccn(C)c2CC1 | 10.1021/jm050846j | ||
CHEMBL201483 | 73039 | 0 | None | -6 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 254 | 0 | 0 | 2 | 2.6 | CN1CCc2ccccc2Cc2ccn(C)c2CC1 | 10.1021/jm050846j | ||
11566745 | 74345 | 0 | None | -3 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | ||
CHEMBL1202298 | 74345 | 0 | None | -3 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | ||
CHEMBL203029 | 74345 | 0 | None | -3 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | ||
168283295 | 190641 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.6 | Cc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5189986 | 190641 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.6 | Cc1ccc(CN2CCC[C@H](OCc3ccc(F)c(C)c3)C2)cc1 | 10.1016/j.bmcl.2022.128615 | ||
168275962 | 190025 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5180979 | 190025 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
168291848 | 191276 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3ncn4ccccc34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5199552 | 191276 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3ncn4ccccc34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
168275089 | 189902 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179198 | 189902 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
71061729 | 160396 | 0 | None | 1 | 4 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 372 | 6 | 0 | 4 | 3.5 | Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL4115493 | 160396 | 0 | None | 1 | 4 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 372 | 6 | 0 | 4 | 3.5 | Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
5025739 | 168630 | 40 | None | 30 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm0305669 | ||
CHEMBL440687 | 168630 | 40 | None | 30 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm0305669 | ||
44438233 | 93177 | 2 | None | -7 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 3 | 1 | 3 | 5.2 | OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246643 | 93177 | 2 | None | -7 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 3 | 1 | 3 | 5.2 | OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
168279825 | 190222 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5183902 | 190222 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(COC2CCN(Cc3cn4ccccc4n3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
44426511 | 136770 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(c1ccc2ccccc2c1)N1CCC(NCc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL375238 | 136770 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.2 | O=C(c1ccc2ccccc2c1)N1CCC(NCc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
44330566 | 206539 | 0 | None | 2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 286 | 1 | 0 | 3 | 4.4 | CCn1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL98945 | 206539 | 0 | None | 2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 286 | 1 | 0 | 3 | 4.4 | CCn1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
11133533 | 44962 | 0 | None | -17 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 418 | 8 | 1 | 5 | 3.6 | COc1cccc(C(=O)NCCCCN2CCN(c3nccc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL152587 | 44962 | 0 | None | -17 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 418 | 8 | 1 | 5 | 3.6 | COc1cccc(C(=O)NCCCCN2CCN(c3nccc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
242 | 467 | 117 | None | -117 | 51 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2011.04.021 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2011.04.021 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2011.04.021 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2011.04.021 | ||
11849736 | 137887 | 0 | None | 1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 7 | 0 | 6 | 3.1 | CCO/N=C(\CCN1CCN(c2nccs2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL377388 | 137887 | 0 | None | 1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 344 | 7 | 0 | 6 | 3.1 | CCO/N=C(\CCN1CCN(c2nccs2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
44431471 | 167814 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1cccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL434583 | 167814 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1cccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
155195496 | 170149 | 0 | None | -72 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 407 | 7 | 3 | 5 | 3.1 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CCCCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4452064 | 170149 | 0 | None | -72 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 407 | 7 | 3 | 5 | 3.1 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CCCCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
122442272 | 137820 | 0 | None | -60 | 15 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | ||
CHEMBL3769968 | 137820 | 0 | None | -60 | 15 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | ||
CHEMBL3771384 | 137820 | 0 | None | -60 | 15 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | ||
44330386 | 106890 | 0 | None | 3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 258 | 0 | 1 | 2 | 3.9 | Clc1sc(Cl)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL317770 | 106890 | 0 | None | 3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 258 | 0 | 1 | 2 | 3.9 | Clc1sc(Cl)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
5311346 | 202453 | 22 | None | -19 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/jm0000113 | ||
CHEMBL1256778 | 202453 | 22 | None | -19 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/jm0000113 | ||
CHEMBL70565 | 202453 | 22 | None | -19 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/jm0000113 | ||
168292124 | 191427 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5201917 | 191427 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(F)c(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
11453253 | 83897 | 0 | None | -54 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 431 | 9 | 1 | 5 | 3.7 | COc1ccc(C(=O)NCCCCN2CCN(c3ccccc3Cl)CC2)cc1OC | 10.1021/jm0611152 | ||
CHEMBL221549 | 83897 | 0 | None | -54 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 431 | 9 | 1 | 5 | 3.7 | COc1ccc(C(=O)NCCCCN2CCN(c3ccccc3Cl)CC2)cc1OC | 10.1021/jm0611152 | ||
22727351 | 12872 | 0 | None | -28 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 406 | 8 | 0 | 6 | 4.4 | O=[N+]([O-])c1cccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1189537 | 12872 | 0 | None | -28 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 406 | 8 | 0 | 6 | 4.4 | O=[N+]([O-])c1cccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL538977 | 12872 | 0 | None | -28 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 406 | 8 | 0 | 6 | 4.4 | O=[N+]([O-])c1cccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)c1 | 10.1016/s0960-894x(02)00179-8 | ||
122442272 | 137820 | 0 | None | -60 | 15 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | ||
CHEMBL3769968 | 137820 | 0 | None | -60 | 15 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | ||
CHEMBL3771384 | 137820 | 0 | None | -60 | 15 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 239 | 5 | 1 | 2 | 2.6 | C=CCOc1cc(F)c(F)cc1C1CC1CN | 10.1021/acs.jmedchem.5b01153 | ||
60167451 | 74998 | 0 | None | -26 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 468 | 7 | 1 | 6 | 5.3 | O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL2037520 | 74998 | 0 | None | -26 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 468 | 7 | 1 | 6 | 5.3 | O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
10456166 | 119128 | 0 | None | -2754 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 444 | 7 | 2 | 3 | 4.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm0611152 | ||
CHEMBL346692 | 119128 | 0 | None | -2754 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 444 | 7 | 2 | 3 | 4.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm0611152 | ||
CHEMBL4285942 | 119128 | 0 | None | -2754 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 444 | 7 | 2 | 3 | 4.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm0611152 | ||
44339984 | 167234 | 0 | None | 10 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL430522 | 167234 | 0 | None | 10 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10641955 | 205121 | 0 | None | 154 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 355 | 3 | 0 | 4 | 4.0 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1cccc(Cl)c1)CC3 | 10.1021/jm970170v | ||
CHEMBL90569 | 205121 | 0 | None | 154 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 355 | 3 | 0 | 4 | 4.0 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1cccc(Cl)c1)CC3 | 10.1021/jm970170v | ||
44394820 | 64520 | 0 | None | 234 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 5.1 | CSc1ccc(-c2ccc(C(=O)NC3CCN(Cc4ccccc4)C3)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL182075 | 64520 | 0 | None | 234 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 5.1 | CSc1ccc(-c2ccc(C(=O)NC3CCN(Cc4ccccc4)C3)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44394629 | 65244 | 0 | None | 234 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 374 | 5 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2cccc(F)c2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL183160 | 65244 | 0 | None | 234 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 374 | 5 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2cccc(F)c2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44214764 | 66863 | 0 | None | 467 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 424 | 5 | 1 | 2 | 5.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL187804 | 66863 | 0 | None | 467 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 424 | 5 | 1 | 2 | 5.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00421-2 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00421-2 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00421-2 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(00)00421-2 | ||
15522515 | 97709 | 0 | None | 93 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 292 | 3 | 0 | 4 | 2.7 | c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL273860 | 97709 | 0 | None | 93 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 292 | 3 | 0 | 4 | 2.7 | c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
44403232 | 70732 | 0 | None | -1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 459 | 8 | 1 | 4 | 4.0 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL195247 | 70732 | 0 | None | -1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 459 | 8 | 1 | 4 | 4.0 | O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2005.07.037 | ||
9949554 | 16674 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1 | 10.1021/jm990266k | ||
CHEMBL124835 | 16674 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1 | 10.1021/jm990266k | ||
44395741 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL476935 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL558392 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
155567971 | 175448 | 0 | None | 25 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 495 | 9 | 2 | 4 | 4.9 | O=C(NCCCN1CCN(c2ccc(Cl)cc2)CC1)NN(Cc1ccc(F)cc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4589982 | 175448 | 0 | None | 25 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 495 | 9 | 2 | 4 | 4.9 | O=C(NCCCN1CCN(c2ccc(Cl)cc2)CC1)NN(Cc1ccc(F)cc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)01056-9 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)01056-9 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)01056-9 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)01056-9 | ||
9861462 | 82921 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 309 | 3 | 2 | 5 | 2.0 | Oc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
CHEMBL219179 | 82921 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 309 | 3 | 2 | 5 | 2.0 | Oc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 | 10.1021/jm060662k | ||
52945819 | 17371 | 0 | None | -1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 354 | 6 | 0 | 3 | 4.2 | Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1258037 | 17371 | 0 | None | -1 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 354 | 6 | 0 | 3 | 4.2 | Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1 | 10.1021/jm100899z | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.12.045 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.12.045 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.12.045 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.12.045 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.12.045 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401895u | ||
137640391 | 156164 | 0 | None | -21 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 7 | 1 | 7 | 2.8 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4070091 | 156164 | 0 | None | -21 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 7 | 1 | 7 | 2.8 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
21219167 | 99192 | 0 | None | 93 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 4.1 | Cc1c(-c2ccccc2)nnn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL284346 | 99192 | 0 | None | 93 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 4.1 | Cc1c(-c2ccccc2)nnn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
10665598 | 34857 | 1 | None | 30 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1 | 10.1021/jm0009989 | ||
CHEMBL143355 | 34857 | 1 | None | 30 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1 | 10.1021/jm0009989 | ||
22100964 | 202257 | 4 | None | 93 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 324 | 3 | 0 | 3 | 4.8 | Clc1ccc2oc(C3=CCN(Cc4ccccc4)CC3)nc2c1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL69356 | 202257 | 4 | None | 93 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 324 | 3 | 0 | 3 | 4.8 | Clc1ccc2oc(C3=CCN(Cc4ccccc4)CC3)nc2c1 | 10.1016/S0960-894X(97)00402-2 | ||
44395741 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL476935 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL558392 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
44395741 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL476935 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL558392 | 180999 | 0 | None | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
44395741 | 180999 | 0 | None | -1 | 10 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL476935 | 180999 | 0 | None | -1 | 10 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL558392 | 180999 | 0 | None | -1 | 10 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2014.04.026 | ||
10015731 | 206428 | 0 | None | -15 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 265 | 2 | 1 | 4 | 2.7 | CCCN1CCO[C@@H]2c3cc(O)ccc3SC[C@H]21 | 10.1021/jm0000113 | ||
CHEMBL98305 | 206428 | 0 | None | -15 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 265 | 2 | 1 | 4 | 2.7 | CCCN1CCO[C@@H]2c3cc(O)ccc3SC[C@H]21 | 10.1021/jm0000113 | ||
127053217 | 138788 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.1 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792556 | 138788 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.1 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4c3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
11581443 | 95954 | 0 | None | -85 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 367 | 8 | 1 | 4 | 3.0 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL26188 | 95954 | 0 | None | -85 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 367 | 8 | 1 | 4 | 3.0 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
9837137 | 111834 | 0 | None | 24 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 204 | 0 | 1 | 2 | 2.9 | Cc1sc(C)c2c1CCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL329276 | 111834 | 0 | None | 24 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 204 | 0 | 1 | 2 | 2.9 | Cc1sc(C)c2c1CCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
127031508 | 138851 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793169 | 138851 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
11624518 | 198659 | 3 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2012.08.011 | ||
CHEMBL597601 | 198659 | 3 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2012.08.011 | ||
145990453 | 166392 | 0 | None | -63 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 404 | 7 | 2 | 4 | 4.1 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4287062 | 166392 | 0 | None | -63 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 404 | 7 | 2 | 4 | 4.1 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
168290895 | 191401 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.5 | Cn1ncc2cc(CN3CCC(OCc4ccc(Cl)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5201507 | 191401 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.5 | Cn1ncc2cc(CN3CCC(OCc4ccc(Cl)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
49783041 | 16989 | 0 | None | -42 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 597 | 7 | 1 | 3 | 6.8 | O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
CHEMBL1256171 | 16989 | 0 | None | -42 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 597 | 7 | 1 | 3 | 6.8 | O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
44436603 | 144683 | 0 | None | -7 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL391257 | 144683 | 0 | None | -7 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1 | 10.1016/j.bmc.2007.08.038 | ||
44249745 | 193772 | 0 | None | -229 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 4 | 0 | 3 | 3.1 | N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1 | 10.1016/j.bmcl.2010.09.142 | ||
CHEMBL552373 | 193772 | 0 | None | -229 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 4 | 0 | 3 | 3.1 | N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1 | 10.1016/j.bmcl.2010.09.142 | ||
CHEMBL567286 | 193772 | 0 | None | -229 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 4 | 0 | 3 | 3.1 | N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1 | 10.1016/j.bmcl.2010.09.142 | ||
4420454 | 55966 | 6 | None | 1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
CHEMBL162762 | 55966 | 6 | None | 1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
44304603 | 201448 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 471 | 8 | 1 | 5 | 5.2 | COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64139 | 201448 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 471 | 8 | 1 | 5 | 5.2 | COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
44304621 | 201728 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.1 | COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL65641 | 201728 | 0 | None | -1 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.1 | COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
44437897 | 152519 | 0 | None | -77 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 6 | 1 | 3 | 2.8 | C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL397592 | 152519 | 0 | None | -77 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 6 | 1 | 3 | 2.8 | C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC | 10.1016/j.bmc.2007.07.017 | ||
11615489 | 69100 | 1 | None | -3 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@H]1CCn2nccc2C1 | 10.1021/jm0503805 | ||
CHEMBL193337 | 69100 | 1 | None | -3 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@H]1CCn2nccc2C1 | 10.1021/jm0503805 | ||
11708363 | 71558 | 1 | None | -5 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@@H]1CCn2nccc2C1 | 10.1021/jm101639t | ||
CHEMBL197159 | 71558 | 1 | None | -5 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@@H]1CCn2nccc2C1 | 10.1021/jm101639t | ||
60167451 | 74998 | 0 | None | -26 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 468 | 7 | 1 | 6 | 5.3 | O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL2037520 | 74998 | 0 | None | -26 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 468 | 7 | 1 | 6 | 5.3 | O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
60167451 | 74998 | 0 | None | -26 | 7 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 468 | 7 | 1 | 6 | 5.3 | O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037520 | 74998 | 0 | None | -26 | 7 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 468 | 7 | 1 | 6 | 5.3 | O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
44338248 | 8267 | 0 | None | -3 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 458 | 6 | 1 | 2 | 6.7 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2cc3ccccc3[nH]2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
CHEMBL109299 | 8267 | 0 | None | -3 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 458 | 6 | 1 | 2 | 6.7 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2cc3ccccc3[nH]2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
155516494 | 169554 | 0 | None | 269 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 358 | 5 | 1 | 4 | 3.1 | CCc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443848 | 169554 | 0 | None | 269 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 358 | 5 | 1 | 4 | 3.1 | CCc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10438027 | 65857 | 0 | None | -645 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 571 | 7 | 1 | 4 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1 | 10.1021/jm900095y | ||
CHEMBL184383 | 65857 | 0 | None | -645 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 571 | 7 | 1 | 4 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1 | 10.1021/jm900095y | ||
11408135 | 123669 | 0 | None | -39 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | ||
CHEMBL363406 | 123669 | 0 | None | -39 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | ||
168292951 | 191550 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5203807 | 191550 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
44582676 | 189187 | 0 | None | -1 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
CHEMBL516088 | 189187 | 0 | None | -1 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
44393658 | 123576 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 475 | 7 | 1 | 3 | 5.9 | Cc1cccc(NC(=O)CN2CCN(c3ccc(C(c4ccccc4)c4ccccc4)cc3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL363308 | 123576 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 475 | 7 | 1 | 3 | 5.9 | Cc1cccc(NC(=O)CN2CCN(c3ccc(C(c4ccccc4)c4ccccc4)cc3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
118643968 | 145437 | 0 | None | -22 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 498 | 10 | 1 | 4 | 4.0 | [O-][S+](CCN1CCN(CC(O)Cc2ccccc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL3918282 | 145437 | 0 | None | -22 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 498 | 10 | 1 | 4 | 4.0 | [O-][S+](CCN1CCN(CC(O)Cc2ccccc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.ejmech.2020.112674 | ||
118643968 | 145437 | 0 | None | -22 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 498 | 10 | 1 | 4 | 4.0 | [O-][S+](CCN1CCN(CC(O)Cc2ccccc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.6b01373 | ||
CHEMBL3918282 | 145437 | 0 | None | -22 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 498 | 10 | 1 | 4 | 4.0 | [O-][S+](CCN1CCN(CC(O)Cc2ccccc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.6b01373 | ||
42626317 | 55959 | 0 | None | -346 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 2.5 | COc1ccccc1N1CCN(CCC(O)CNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm900095y | ||
CHEMBL1627322 | 55959 | 0 | None | -346 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 2.5 | COc1ccccc1N1CCN(CCC(O)CNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm900095y | ||
44350664 | 117646 | 0 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL340816 | 117646 | 0 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL553417 | 117646 | 0 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
44350664 | 117646 | 0 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL340816 | 117646 | 0 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL553417 | 117646 | 0 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
9931571 | 5263 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 413 | 5 | 1 | 4 | 2.5 | O=C(O)[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL106827 | 5263 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 413 | 5 | 1 | 4 | 2.5 | O=C(O)[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL5086564 | 213262 | 0 | None | -316 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | None | None | None | CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2C[C@@H]1C[C@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.1c00611 | ||||
71658204 | 89974 | 0 | None | -37 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Br)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386618 | 89974 | 0 | None | -37 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Br)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
11351639 | 60200 | 0 | None | -95 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 5.3 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm049465g | ||
CHEMBL175734 | 60200 | 0 | None | -95 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 5.3 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm049465g | ||
11351639 | 60200 | 0 | None | -95 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 5.3 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm900095y | ||
CHEMBL175734 | 60200 | 0 | None | -95 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 5.3 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm900095y | ||
56593482 | 3878 | 1 | None | -162 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 4.6 | O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | ||
7650 | 3878 | 1 | None | -162 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 4.6 | O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | ||
CHEMBL2165119 | 3878 | 1 | None | -162 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 4.6 | O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | ||
3037308 | 43829 | 19 | None | -74 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm9810396 | ||
CHEMBL151475 | 43829 | 19 | None | -74 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm9810396 | ||
154727843 | 175859 | 1 | None | -1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 13 | 0 | 6 | 5.6 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4448853 | 175859 | 1 | None | -1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 13 | 0 | 6 | 5.6 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596221 | 175859 | 1 | None | -1 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 13 | 0 | 6 | 5.6 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | ||
44394590 | 127027 | 0 | None | 50 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2ccsc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL366304 | 127027 | 0 | None | 50 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2ccsc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
71458071 | 79090 | 0 | None | 43 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL2113718 | 79090 | 0 | None | 43 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1 | 10.1016/s0960-894x(02)00316-5 | ||
10735405 | 205678 | 0 | None | 4 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 333 | 4 | 1 | 4 | 4.1 | Oc1nc(-c2ccccc2)cn1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL93958 | 205678 | 0 | None | 4 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 333 | 4 | 1 | 4 | 4.1 | Oc1nc(-c2ccccc2)cn1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
10947658 | 28490 | 0 | None | -16 | 16 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
CHEMBL137781 | 28490 | 0 | None | -16 | 16 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
44278789 | 99455 | 0 | None | 131 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 1 | 4 | 4.1 | OC(COc1cccc2ccccc12)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL286177 | 99455 | 0 | None | 131 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 1 | 4 | 4.1 | OC(COc1cccc2ccccc12)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
4088306 | 100171 | 6 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 7 | 1 | 3 | 4.0 | OC(COc1ccc(Cl)cc1)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL29206 | 100171 | 6 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 7 | 1 | 3 | 4.0 | OC(COc1ccc(Cl)cc1)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
135481864 | 12244 | 0 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 5 | 1 | 5 | 2.9 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1185415 | 12244 | 0 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 5 | 1 | 5 | 2.9 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL412665 | 12244 | 0 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 5 | 1 | 5 | 2.9 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
10837494 | 205721 | 0 | None | 8 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 7 | 2 | 4 | 4.5 | COc1cc(NC(=O)C2CCCC2)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL94200 | 205721 | 0 | None | 8 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 7 | 2 | 4 | 4.5 | COc1cc(NC(=O)C2CCCC2)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
155516873 | 169561 | 0 | None | 28 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 445 | 9 | 2 | 6 | 2.9 | O=C(NCCCN1CCN(c2ncccn2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4443944 | 169561 | 0 | None | 28 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 445 | 9 | 2 | 6 | 2.9 | O=C(NCCCN1CCN(c2ncccn2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm2013419 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm2013419 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm2013419 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm2013419 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm2013419 | ||
25072635 | 111291 | 0 | None | -8 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12 | 10.1021/jm5004039 | ||
CHEMBL3287399 | 111291 | 0 | None | -8 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12 | 10.1021/jm5004039 | ||
11720302 | 165705 | 0 | None | -9 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 503 | 7 | 1 | 3 | 5.2 | O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm060138d | ||
CHEMBL426863 | 165705 | 0 | None | -9 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 503 | 7 | 1 | 3 | 5.2 | O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm060138d | ||
21219156 | 95382 | 0 | None | 67 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 4.1 | Cc1nnn(C2CCN(Cc3ccccc3)CC2)c1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL25887 | 95382 | 0 | None | 67 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 4.1 | Cc1nnn(C2CCN(Cc3ccccc3)CC2)c1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
44376241 | 119610 | 0 | None | 51 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 354 | 5 | 0 | 6 | 2.5 | COc1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL351098 | 119610 | 0 | None | 51 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 354 | 5 | 0 | 6 | 2.5 | COc1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0104825 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0104825 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0104825 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0104825 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0104825 | ||
127032083 | 138917 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 5 | 1 | 4 | 2.8 | c1ccc(OC[C@@H]2CN(Cc3n[nH]c4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793996 | 138917 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 5 | 1 | 4 | 2.8 | c1ccc(OC[C@@H]2CN(Cc3n[nH]c4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
9967004 | 39120 | 1 | None | 45 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 3 | 1 | 4 | 2.3 | O=C1COc2ccc(CN3CCN(c4ccccc4)CC3)cc2N1 | 10.1021/jm990277d | ||
CHEMBL147130 | 39120 | 1 | None | 45 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 3 | 1 | 4 | 2.3 | O=C1COc2ccc(CN3CCN(c4ccccc4)CC3)cc2N1 | 10.1021/jm990277d | ||
44591045 | 176163 | 0 | None | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 3 | 1 | 3 | 3.9 | Clc1ccc(N2CCCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL460223 | 176163 | 0 | None | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 3 | 1 | 3 | 3.9 | Clc1ccc(N2CCCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/j.bmc.2008.12.054 | ||
11681599 | 74823 | 0 | None | -338 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | 10.1021/jm051237e | ||
CHEMBL203637 | 74823 | 0 | None | -338 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | 10.1021/jm051237e | ||
44380697 | 57787 | 0 | None | 3 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 373 | 6 | 2 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL167414 | 57787 | 0 | None | 3 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 373 | 6 | 2 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
11624518 | 198659 | 3 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL597601 | 198659 | 3 | None | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
60165413 | 75010 | 0 | None | -52 | 7 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.5 | O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037531 | 75010 | 0 | None | -52 | 7 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.5 | O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
122189392 | 122731 | 0 | None | -81 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 441 | 5 | 0 | 7 | 3.6 | Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613878 | 122731 | 0 | None | -81 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 441 | 5 | 0 | 7 | 3.6 | Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.07.050 | ||
122177642 | 120697 | 0 | None | -81 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | ||
CHEMBL3577343 | 120697 | 0 | None | -81 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | ||
11348526 | 6284 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 345 | 7 | 0 | 4 | 3.5 | CCOc1ccccc1OCC1CN(Cc2ccc(F)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL108211 | 6284 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 345 | 7 | 0 | 4 | 3.5 | CCOc1ccccc1OCC1CN(Cc2ccc(F)cc2)CCO1 | 10.1021/jm031111m | ||
10786474 | 205441 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 3.2 | COc1cccc(C(=O)N(C)CCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL92411 | 205441 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 3.2 | COc1cccc(C(=O)N(C)CCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
44371996 | 53341 | 0 | None | 2 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160266 | 53341 | 0 | None | 2 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
11223708 | 165756 | 0 | None | -11 | 3 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | ||
CHEMBL427173 | 165756 | 0 | None | -11 | 3 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | ||
44263882 | 96776 | 0 | None | 2 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL268558 | 96776 | 0 | None | 2 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.5 | Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
45482180 | 196227 | 0 | None | -218 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 544 | 12 | 1 | 7 | 4.6 | COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1 | 10.1016/j.bmc.2009.06.041 | ||
CHEMBL572867 | 196227 | 0 | None | -218 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 544 | 12 | 1 | 7 | 4.6 | COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1 | 10.1016/j.bmc.2009.06.041 | ||
25139478 | 184373 | 0 | None | -138 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 0 | 4 | 7.5 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm800895v | ||
CHEMBL485384 | 184373 | 0 | None | -138 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 0 | 4 | 7.5 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm800895v | ||
44319361 | 204007 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 337 | 4 | 0 | 4 | 3.4 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL82527 | 204007 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 337 | 4 | 0 | 4 | 3.4 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL5084145 | 213126 | 0 | None | -977 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | None | None | None | CN(C)C(=O)C(CCN1CCc2ccc(C#N)cc2C1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
21559988 | 112928 | 2 | None | -28 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.0 | O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318852 | 112928 | 2 | None | -28 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.0 | O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2014.06.079 | ||
168279082 | 190139 | 0 | None | -1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5182602 | 190139 | 0 | None | -1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
44431485 | 87644 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 389 | 5 | 1 | 4 | 4.1 | O=C(NC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234644 | 87644 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 389 | 5 | 1 | 4 | 4.1 | O=C(NC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
44415569 | 165381 | 0 | None | -1148 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 505 | 4 | 1 | 7 | 4.5 | COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL425069 | 165381 | 0 | None | -1148 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 505 | 4 | 1 | 7 | 4.5 | COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | ||
51354275 | 59868 | 0 | None | -165 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 4.9 | O=C(NC/C=C/CN1CCN(c2ccccc2OCCF)CC1)c1ccc(-c2ccsc2)cc1 | 10.1021/jm101323b | ||
CHEMBL1689012 | 59868 | 0 | None | -165 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 4.9 | O=C(NC/C=C/CN1CCN(c2ccccc2OCCF)CC1)c1ccc(-c2ccsc2)cc1 | 10.1021/jm101323b | ||
CHEMBL1739787 | 59868 | 0 | None | -165 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 4.9 | O=C(NC/C=C/CN1CCN(c2ccccc2OCCF)CC1)c1ccc(-c2ccsc2)cc1 | 10.1021/jm101323b | ||
12280580 | 43819 | 1 | None | -2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@@H]1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
CHEMBL15146 | 43819 | 1 | None | -2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@@H]1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
71062889 | 147742 | 0 | None | 19 | 5 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 1.8 | O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21 | nan | ||
CHEMBL3936595 | 147742 | 0 | None | 19 | 5 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 1.8 | O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21 | nan | ||
10894276 | 41082 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 383 | 2 | 1 | 5 | 4.3 | Cc1ccc2c(c1)C(N1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL148965 | 41082 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 383 | 2 | 1 | 5 | 4.3 | Cc1ccc2c(c1)C(N1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
168280464 | 190142 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 3.8 | Cc1ccccc1CO[C@H]1CCCN(Cc2cn3ccccc3n2)C1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5182635 | 190142 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 3.8 | Cc1ccccc1CO[C@H]1CCCN(Cc2cn3ccccc3n2)C1 | 10.1016/j.bmcl.2022.128615 | ||
154703764 | 175736 | 1 | None | -46 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 505 | 13 | 1 | 4 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4455719 | 175736 | 1 | None | -46 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 505 | 13 | 1 | 4 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595265 | 175736 | 1 | None | -46 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 505 | 13 | 1 | 4 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
71458739 | 81411 | 0 | None | -112 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 466 | 7 | 0 | 5 | 4.7 | COc1ccccc1N1CCN(CCN(C(=O)c2ccc3ccccc3c2)c2ccccn2)CC1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164347 | 81411 | 0 | None | -112 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 466 | 7 | 0 | 5 | 4.7 | COc1ccccc1N1CCN(CCN(C(=O)c2ccc3ccccc3c2)c2ccccn2)CC1 | 10.1016/j.bmcl.2012.05.119 | ||
16090821 | 81421 | 0 | None | -47 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 | 10.1021/jm060213k | ||
CHEMBL216439 | 81421 | 0 | None | -47 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 | 10.1021/jm060213k | ||
53248673 | 66071 | 0 | None | -724 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 441 | 10 | 1 | 5 | 3.9 | O=C1CCc2ccc(OCCCCN3CCN(c4ccccc4OCCF)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813591 | 66071 | 0 | None | -724 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 441 | 10 | 1 | 5 | 3.9 | O=C1CCc2ccc(OCCCCN3CCN(c4ccccc4OCCF)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851831 | 66071 | 0 | None | -724 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 441 | 10 | 1 | 5 | 3.9 | O=C1CCc2ccc(OCCCCN3CCN(c4ccccc4OCCF)CC3)cc2N1 | 10.1016/j.bmc.2011.04.021 | ||
90644071 | 111550 | 0 | None | 1 | 5 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.2 | Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289655 | 111550 | 0 | None | 1 | 5 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.2 | Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
37461 | 16953 | 10 | None | -208 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL1255588 | 16953 | 10 | None | -208 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1 | 10.1016/S0960-894X(97)00194-7 | ||
10436285 | 101482 | 0 | None | -954 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
CHEMBL301242 | 101482 | 0 | None | -954 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
1599 | 2309 | 47 | None | -2238 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
3955 | 2309 | 47 | None | -2238 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
7215 | 2309 | 47 | None | -2238 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
CHEMBL841 | 2309 | 47 | None | -2238 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
DB00836 | 2309 | 47 | None | -2238 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
10436285 | 101482 | 0 | None | -954 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm040190e | ||
CHEMBL301242 | 101482 | 0 | None | -954 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm040190e | ||
118719796 | 115223 | 0 | None | -102 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 456 | 9 | 0 | 7 | 4.4 | COc1ccccc1N1CCN(CCCCCc2cn(-c3cccc4cnccc34)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353899 | 115223 | 0 | None | -102 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 456 | 9 | 0 | 7 | 4.4 | COc1ccccc1N1CCN(CCCCCc2cn(-c3cccc4cnccc34)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
164608999 | 183802 | 0 | None | -141 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 310 | 6 | 1 | 4 | 2.8 | Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4845741 | 183802 | 0 | None | -141 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 310 | 6 | 1 | 4 | 2.8 | Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
71659909 | 89960 | 0 | None | -263 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 463 | 9 | 1 | 5 | 5.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(-c3ccsc3)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386604 | 89960 | 0 | None | -263 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 463 | 9 | 1 | 5 | 5.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(-c3ccsc3)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
168271806 | 189925 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179482 | 189925 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.0 | Cc1cc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)ccc1F | 10.1016/j.bmcl.2022.128615 | ||
44415690 | 79727 | 0 | None | -851 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 473 | 2 | 1 | 5 | 5.1 | Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL213336 | 79727 | 0 | None | -851 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 473 | 2 | 1 | 5 | 5.1 | Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | ||
164608999 | 183802 | 0 | None | -141 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 310 | 6 | 1 | 4 | 2.8 | Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4845741 | 183802 | 0 | None | -141 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 310 | 6 | 1 | 4 | 2.8 | Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
135887931 | 11962 | 0 | None | 14 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 3.3 | c1ccc(N2CCN(CCCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1183657 | 11962 | 0 | None | 14 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 3.3 | c1ccc(N2CCN(CCCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL309858 | 11962 | 0 | None | 14 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 3.3 | c1ccc(N2CCN(CCCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
122205437 | 136787 | 0 | None | -61 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2sccc2CC1 | 10.1039/C5MD00258C | ||
CHEMBL3752512 | 136787 | 0 | None | -61 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2sccc2CC1 | 10.1039/C5MD00258C | ||
71658073 | 89968 | 0 | None | -24 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(C)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386612 | 89968 | 0 | None | -24 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(C)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
72191067 | 91924 | 0 | None | -14 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 392 | 8 | 0 | 7 | 3.0 | COc1ccccc1N1CCN(CCCCn2cc(-c3cccnc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
CHEMBL2430439 | 91924 | 0 | None | -14 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 392 | 8 | 0 | 7 | 3.0 | COc1ccccc1N1CCN(CCCCn2cc(-c3cccnc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
10497179 | 203401 | 1 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 4.6 | c1ccc(CCN2CCC(c3cc(-c4cccs4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL77743 | 203401 | 1 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 4.6 | c1ccc(CCN2CCC(c3cc(-c4cccs4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
135492584 | 11228 | 0 | None | 95 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 7 | 1 | 7 | 2.5 | c1cnc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1179503 | 11228 | 0 | None | 95 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 7 | 1 | 7 | 2.5 | c1cnc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL80645 | 11228 | 0 | None | 95 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 7 | 1 | 7 | 2.5 | c1cnc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
44380715 | 58704 | 0 | None | 2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL169222 | 58704 | 0 | None | 2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
10639353 | 114298 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 319 | 3 | 0 | 3 | 4.2 | O=c1ccc2ccc(CN3CCC(c4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL333983 | 114298 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 319 | 3 | 0 | 3 | 4.2 | O=c1ccc2ccc(CN3CCC(c4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
155560295 | 174475 | 0 | None | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 463 | 9 | 2 | 6 | 3.0 | O=C(NCCCN1CCN(c2ncccn2)CC1)NN(Cc1ccc(F)cc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4567758 | 174475 | 0 | None | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 463 | 9 | 2 | 6 | 3.0 | O=C(NCCCN1CCN(c2ncccn2)CC1)NN(Cc1ccc(F)cc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
10224165 | 168493 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 423 | 3 | 0 | 3 | 4.1 | CC1(C)Cc2cccc3c2N1C(=O)C(N1CCN(Cc2ccc(Cl)cc2)CC1)CC3 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL439646 | 168493 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 423 | 3 | 0 | 3 | 4.1 | CC1(C)Cc2cccc3c2N1C(=O)C(N1CCN(Cc2ccc(Cl)cc2)CC1)CC3 | 10.1016/s0960-894x(02)01056-9 | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | ||
52947756 | 16988 | 0 | None | -4 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 567 | 6 | 0 | 2 | 8.3 | O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
CHEMBL1256170 | 16988 | 0 | None | -4 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 567 | 6 | 0 | 2 | 8.3 | O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
11742798 | 96666 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCN(c2ccccc2OC)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL26758 | 96666 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCN(c2ccccc2OC)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
53364154 | 63512 | 0 | None | 1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1013 | 31 | 0 | 16 | 9.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803025 | 63512 | 0 | None | 1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1013 | 31 | 0 | 16 | 9.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
53364227 | 63516 | 0 | None | -3 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1033 | 32 | 0 | 19 | 6.3 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803029 | 63516 | 0 | None | -3 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1033 | 32 | 0 | 19 | 6.3 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
53363202 | 63525 | 0 | None | -1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 961 | 28 | 0 | 15 | 8.7 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803055 | 63525 | 0 | None | -1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 961 | 28 | 0 | 15 | 8.7 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
118709176 | 112925 | 0 | None | -13 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1106 | 29 | 0 | 14 | 11.8 | O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318849 | 112925 | 0 | None | -13 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1106 | 29 | 0 | 14 | 11.8 | O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
137644833 | 157594 | 0 | None | -3 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 408 | 9 | 0 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4087187 | 157594 | 0 | None | -3 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 408 | 9 | 0 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
71459760 | 83658 | 0 | None | 3 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 398 | 5 | 0 | 3 | 5.3 | CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207634 | 83658 | 0 | None | 3 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 398 | 5 | 0 | 3 | 5.3 | CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2 | 10.1016/j.bmcl.2012.09.064 | ||
13091273 | 181856 | 0 | None | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL478617 | 181856 | 0 | None | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL553327 | 181856 | 0 | None | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
127053219 | 138934 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794174 | 138934 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.8 | Fc1cc(CN2CCO[C@H](COc3ccccc3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
13091273 | 181856 | 0 | None | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL478617 | 181856 | 0 | None | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL553327 | 181856 | 0 | None | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL5083441 | 213087 | 0 | None | 9 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CCc1cccc(N2CCN(CCC(c3cccc(O)c3)c3cccc(O)c3)CC2)c1Cl | 10.1021/acs.jmedchem.1c00611 | ||||
90644062 | 111542 | 0 | None | 8 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289647 | 111542 | 0 | None | 8 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
44372296 | 118982 | 0 | None | 72 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1 | 10.1021/jm0611152 | ||
CHEMBL345357 | 118982 | 0 | None | 72 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1 | 10.1021/jm0611152 | ||
10690882 | 195857 | 0 | None | 501 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 6 | 0 | 4 | 4.5 | COc1cc2ccccc2cc1C(=O)OCC1CCN(Cc2ccccc2)C1 | 10.1021/jm960017l | ||
CHEMBL57019 | 195857 | 0 | None | 501 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 6 | 0 | 4 | 4.5 | COc1cc2ccccc2cc1C(=O)OCC1CCN(Cc2ccccc2)C1 | 10.1021/jm960017l | ||
10548329 | 200941 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 4.5 | COc1cc2ccccc2cc1C(=O)NCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL61248 | 200941 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 4.5 | COc1cc2ccccc2cc1C(=O)NCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
44273741 | 78098 | 0 | None | 31 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 7 | 1 | 3 | 4.6 | O=C(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21119 | 78098 | 0 | None | 31 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 7 | 1 | 3 | 4.6 | O=C(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/0960-894X(96)00198-9 | ||
137644962 | 157947 | 0 | None | 74 | 8 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4091058 | 157947 | 0 | None | 74 | 8 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
11779642 | 205132 | 0 | None | -2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | C[C@@H]1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL90654 | 205132 | 0 | None | -2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | C[C@@H]1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
25139479 | 183735 | 0 | None | -21 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 438 | 10 | 0 | 4 | 6.2 | C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1 | 10.1021/jm800895v | ||
CHEMBL484202 | 183735 | 0 | None | -21 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 438 | 10 | 0 | 4 | 6.2 | C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1 | 10.1021/jm800895v | ||
57390119 | 68961 | 0 | None | -45 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 969 | 33 | 2 | 14 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928127 | 68961 | 0 | None | -45 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 969 | 33 | 2 | 14 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
137655556 | 157993 | 0 | None | -56 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 447 | 7 | 2 | 7 | 3.3 | O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4091507 | 157993 | 0 | None | -56 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 447 | 7 | 2 | 7 | 3.3 | O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 | 10.1021/acs.jmedchem.7b00363 | ||
44436610 | 91517 | 0 | None | -25 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 505 | 7 | 1 | 3 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241436 | 91517 | 0 | None | -25 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 505 | 7 | 1 | 3 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1 | 10.1016/j.bmc.2007.08.038 | ||
52937777 | 60843 | 0 | None | -323 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 464 | 10 | 1 | 4 | 5.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1 | 10.1021/jm101639t | ||
CHEMBL1765630 | 60843 | 0 | None | -323 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 464 | 10 | 1 | 4 | 5.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1 | 10.1021/jm101639t | ||
155562543 | 174600 | 0 | None | -3 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 4 | 0 | 4 | 3.2 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4570411 | 174600 | 0 | None | -3 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 4 | 0 | 4 | 3.2 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
10667966 | 56865 | 0 | None | 1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 387 | 5 | 0 | 1 | 6.1 | CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
CHEMBL164736 | 56865 | 0 | None | 1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 387 | 5 | 0 | 1 | 6.1 | CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
42626240 | 55944 | 0 | None | -239 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC[C@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/ml500006v | ||
CHEMBL1627307 | 55944 | 0 | None | -239 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC[C@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/ml500006v | ||
11626748 | 139629 | 0 | None | -2 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 459 | 4 | 0 | 7 | 3.1 | CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL380287 | 139629 | 0 | None | -2 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 459 | 4 | 0 | 7 | 3.1 | CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1 | 10.1021/jm060166w | ||
155562543 | 174600 | 0 | None | -3 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 4 | 0 | 4 | 3.2 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4570411 | 174600 | 0 | None | -3 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 353 | 4 | 0 | 4 | 3.2 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
22910005 | 11494 | 1 | None | -147 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)OC(CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
CHEMBL1180629 | 11494 | 1 | None | -147 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)OC(CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
CHEMBL135395 | 11494 | 1 | None | -147 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)OC(CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
25141535 | 55945 | 0 | None | -1380 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 2.5 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm900095y | ||
CHEMBL1627308 | 55945 | 0 | None | -1380 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 2.5 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm900095y | ||
10515841 | 206524 | 0 | None | -54 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 265 | 2 | 1 | 4 | 2.7 | CCCN1CCO[C@@H]2c3cc(O)ccc3SC[C@@H]21 | 10.1021/jm0000113 | ||
CHEMBL98836 | 206524 | 0 | None | -54 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 265 | 2 | 1 | 4 | 2.7 | CCCN1CCO[C@@H]2c3cc(O)ccc3SC[C@@H]21 | 10.1021/jm0000113 | ||
71062567 | 159868 | 0 | None | -2 | 2 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 353 | 6 | 0 | 5 | 2.5 | Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL4111349 | 159868 | 0 | None | -2 | 2 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 353 | 6 | 0 | 5 | 2.5 | Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
168280776 | 190564 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5188602 | 190564 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.7 | Fc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
134136246 | 142006 | 0 | None | -2 | 6 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 275 | 3 | 0 | 1 | 4.1 | C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3890841 | 142006 | 0 | None | -2 | 6 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 275 | 3 | 0 | 1 | 4.1 | C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
134136246 | 142006 | 0 | None | -2 | 6 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 275 | 3 | 0 | 1 | 4.1 | C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3890841 | 142006 | 0 | None | -2 | 6 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 275 | 3 | 0 | 1 | 4.1 | C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21 | 10.1016/j.bmc.2016.09.019 | ||
44438227 | 93122 | 0 | None | -18 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 354 | 4 | 2 | 2 | 4.3 | OCC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246437 | 93122 | 0 | None | -18 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 354 | 4 | 2 | 2 | 4.3 | OCC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
25130157 | 102832 | 0 | None | -275 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 367 | 3 | 1 | 3 | 5.1 | O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12 | 10.1021/jm800532x | ||
CHEMBL3084515 | 102832 | 0 | None | -275 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 367 | 3 | 1 | 3 | 5.1 | O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12 | 10.1021/jm800532x | ||
130431303 | 172368 | 0 | None | -173 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 419 | 8 | 3 | 5 | 2.2 | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3nc(C)c[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4516799 | 172368 | 0 | None | -173 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 419 | 8 | 3 | 5 | 2.2 | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3nc(C)c[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
3246443 | 37453 | 2 | None | -316 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 325 | 1 | 1 | 5 | 2.8 | COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | ||
CHEMBL1457510 | 37453 | 2 | None | -316 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 325 | 1 | 1 | 5 | 2.8 | COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
22727335 | 13374 | 0 | None | -20 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 391 | 8 | 0 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1193307 | 13374 | 0 | None | -20 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 391 | 8 | 0 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL544689 | 13374 | 0 | None | -20 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 391 | 8 | 0 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
168280974 | 190269 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5184607 | 190269 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 4.5 | COc1ccc(CN2CCC[C@@H](OCc3ccc(F)c(C)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
10524285 | 200734 | 0 | None | 6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 387 | 7 | 0 | 3 | 5.3 | COc1cc2ccccc2cc1CC(=O)CC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL61090 | 200734 | 0 | None | 6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 387 | 7 | 0 | 3 | 5.3 | COc1cc2ccccc2cc1CC(=O)CC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
42273483 | 164743 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.0 | CC(C)(C)C(=O)NCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL423287 | 164743 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.0 | CC(C)(C)C(=O)NCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
75306277 | 108767 | 0 | None | -99 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | ||
CHEMBL3217984 | 108767 | 0 | None | -99 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | ||
11384664 | 82699 | 0 | None | -234 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 421 | 7 | 1 | 3 | 4.8 | O=C(NCCCCN1CCN(c2ccccc2Cl)CC1)c1ccc2ccccc2c1 | 10.1021/jm0611152 | ||
CHEMBL218203 | 82699 | 0 | None | -234 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 421 | 7 | 1 | 3 | 4.8 | O=C(NCCCCN1CCN(c2ccccc2Cl)CC1)c1ccc2ccccc2c1 | 10.1021/jm0611152 | ||
153287574 | 174675 | 0 | None | -26 | 10 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 266 | 2 | 1 | 2 | 4.0 | CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | ||
CHEMBL4572167 | 174675 | 0 | None | -26 | 10 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 266 | 2 | 1 | 2 | 4.0 | CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | ||
10245409 | 49520 | 0 | None | 99 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.4 | c1ccc(CCC2CCN(Cc3cc4ccc[nH]c-4n3)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL156732 | 49520 | 0 | None | 99 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.4 | c1ccc(CCC2CCN(Cc3cc4ccc[nH]c-4n3)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
44214767 | 66707 | 0 | None | 602 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccsc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL187122 | 66707 | 0 | None | 602 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccsc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44394666 | 125271 | 0 | None | 501 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2ccsc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL364782 | 125271 | 0 | None | 501 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2ccsc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44394742 | 165568 | 0 | None | 34 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2ccsc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL426062 | 165568 | 0 | None | 34 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2ccsc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
210956 | 205017 | 5 | None | 3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 292 | 1 | 0 | 3 | 3.5 | CN1CCN(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL89970 | 205017 | 5 | None | 3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 292 | 1 | 0 | 3 | 3.5 | CN1CCN(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
10570080 | 106650 | 0 | None | 41 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 353 | 4 | 1 | 4 | 4.8 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(CC2CCCCC2)CC1 | 10.1021/jm991029k | ||
CHEMBL316125 | 106650 | 0 | None | 41 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 353 | 4 | 1 | 4 | 4.8 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(CC2CCCCC2)CC1 | 10.1021/jm991029k | ||
210956 | 205017 | 5 | None | 3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 292 | 1 | 0 | 3 | 3.5 | CN1CCN(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL89970 | 205017 | 5 | None | 3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 292 | 1 | 0 | 3 | 3.5 | CN1CCN(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
9840365 | 107966 | 0 | None | 109 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 327 | 7 | 1 | 4 | 3.0 | O[C@@H](COc1ccccc1)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL31991 | 107966 | 0 | None | 109 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 327 | 7 | 1 | 4 | 3.0 | O[C@@H](COc1ccccc1)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
792265 | 91722 | 8 | None | 29 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 346 | 5 | 0 | 3 | 4.6 | CCOc1ccccc1N1CCN(Cc2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420781 | 91722 | 8 | None | 29 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 346 | 5 | 0 | 3 | 4.6 | CCOc1ccccc1N1CCN(Cc2cccc3ccccc23)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
9860183 | 106745 | 0 | None | 89 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 232 | 0 | 0 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL316727 | 106745 | 0 | None | 89 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 232 | 0 | 0 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
10588194 | 18732 | 3 | None | 67 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 271 | 9 | 1 | 3 | 3.1 | c1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL128524 | 18732 | 3 | None | 67 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 271 | 9 | 1 | 3 | 3.1 | c1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
44336061 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL320597 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
44335889 | 106870 | 0 | None | 354 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 381 | 4 | 0 | 3 | 3.2 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1F | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL317670 | 106870 | 0 | None | 354 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 381 | 4 | 0 | 3 | 3.2 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1F | 10.1016/s0960-894x(02)00656-x | ||
44336074 | 4825 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 4.2 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104497 | 4825 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 4.2 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335812 | 4869 | 0 | None | 19 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 4 | 0 | 2 | 4.6 | Cc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104716 | 4869 | 0 | None | 19 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 4 | 0 | 2 | 4.6 | Cc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
137659990 | 158684 | 0 | None | -3 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 436 | 10 | 2 | 7 | 4.3 | CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4098859 | 158684 | 0 | None | -3 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 436 | 10 | 2 | 7 | 4.3 | CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
122180955 | 121256 | 0 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 386 | 7 | 1 | 3 | 4.6 | CCCN(CCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3589576 | 121256 | 0 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 386 | 7 | 1 | 3 | 4.6 | CCCN(CCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
11559581 | 78009 | 0 | None | 194 | 6 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 361 | 3 | 0 | 5 | 3.4 | Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL211135 | 78009 | 0 | None | 194 | 6 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 361 | 3 | 0 | 5 | 3.4 | Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
10476504 | 33268 | 1 | None | -1 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
CHEMBL142020 | 33268 | 1 | None | -1 | 7 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
11464857 | 4713 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 6 | 0 | 4 | 4.8 | COc1cc(Cl)ccc1OCC1CN(Cc2ccc(Br)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL104035 | 4713 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 6 | 0 | 4 | 4.8 | COc1cc(Cl)ccc1OCC1CN(Cc2ccc(Br)cc2)CCCO1 | 10.1021/jm031111m | ||
44376209 | 56039 | 0 | None | 33 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(OC[C@H]2CC[C@H]3CN(c4ncc(F)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL163009 | 56039 | 0 | None | 33 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(OC[C@H]2CC[C@H]3CN(c4ncc(F)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
44336061 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL320597 | 108134 | 0 | None | 56 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
10571927 | 205681 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccccc2Cl)CC1 | 10.1021/jm991029k | ||
CHEMBL93970 | 205681 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(Cc2ccccc2Cl)CC1 | 10.1021/jm991029k | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
9802631 | 111505 | 1 | None | 10 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 427 | 7 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL328866 | 111505 | 1 | None | 10 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 427 | 7 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
10716980 | 206102 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 419 | 6 | 2 | 4 | 3.8 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2CCCCC2)C1 | 10.1021/jm9601720 | ||
CHEMBL96369 | 206102 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 419 | 6 | 2 | 4 | 3.8 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2CCCCC2)C1 | 10.1021/jm9601720 | ||
18624462 | 166390 | 0 | None | 10 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 427 | 7 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)C1 | 10.1021/jm030480f | ||
CHEMBL428705 | 166390 | 0 | None | 10 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 427 | 7 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)C1 | 10.1021/jm030480f | ||
10831735 | 31540 | 0 | None | 2511 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL140594 | 31540 | 0 | None | 2511 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1 | 10.1021/jm0009989 | ||
137655636 | 158190 | 0 | None | 93 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 376 | 7 | 0 | 2 | 4.7 | O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4093527 | 158190 | 0 | None | 93 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 376 | 7 | 0 | 2 | 4.7 | O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0611152 | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0611152 | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0611152 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970170v | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970170v | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970170v | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970170v | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970170v | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm015522j | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm015522j | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm015522j | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm049612a | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm049612a | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm049612a | ||
10784211 | 103705 | 0 | None | 223 | 4 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CC[C@@H]3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
CHEMBL309730 | 103705 | 0 | None | 223 | 4 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CC[C@@H]3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1016/j.bmcl.2007.12.026 | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1016/j.bmcl.2007.12.026 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970422s | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970422s | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970422s | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970422s | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970422s | ||
778880 | 50076 | 11 | None | 26 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 339 | 6 | 1 | 4 | 2.2 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL157222 | 50076 | 11 | None | 26 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 339 | 6 | 1 | 4 | 2.2 | COc1cccc(C(=O)NCCN2CCN(c3ccccc3)CC2)c1 | 10.1021/jm020952a | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00073a021 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00073a021 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00073a021 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00073a021 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00073a021 | ||
127032384 | 138846 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793137 | 138846 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
137643309 | 157869 | 0 | None | -1 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 421 | 10 | 1 | 6 | 4.3 | CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4090208 | 157869 | 0 | None | -1 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 421 | 10 | 1 | 6 | 4.3 | CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm900690y | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm900690y | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm900690y | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0104825 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0104825 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0104825 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0104825 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0104825 | ||
45361874 | 169454 | 2 | None | 48 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4442548 | 169454 | 2 | None | 48 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.2c00840 | ||
168285560 | 192316 | 0 | None | 1148 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5196873 | 192316 | 0 | None | 1148 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222201 | 192316 | 0 | None | 1148 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 350 | 5 | 0 | 4 | 2.6 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1021/acs.jmedchem.8b00265 | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm0611152 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970111h | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970111h | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970111h | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970111h | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm970111h | ||
9847013 | 45104 | 0 | None | 26 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 458 | 6 | 1 | 5 | 6.3 | Cc1nc(Cl)c(Sc2ccc(Cl)cc2)c(NC2CCN(Cc3ccccc3)CC2)n1 | 10.1016/s0960-894x(01)00167-6 | ||
CHEMBL15270 | 45104 | 0 | None | 26 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 458 | 6 | 1 | 5 | 6.3 | Cc1nc(Cl)c(Sc2ccc(Cl)cc2)c(NC2CCN(Cc3ccccc3)CC2)n1 | 10.1016/s0960-894x(01)00167-6 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9600712 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9600712 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9600712 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9600712 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9600712 | ||
11811808 | 45161 | 0 | None | -5 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1cccc(C(=O)NCCCCN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL152756 | 45161 | 0 | None | -5 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1cccc(C(=O)NCCCCN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
3645619 | 2985 | 13 | None | -4 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/acs.jmedchem.9b01085 | ||
975 | 2985 | 13 | None | -4 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL45244 | 2985 | 13 | None | -4 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/acs.jmedchem.9b01085 | ||
27620 | 140287 | 13 | None | 5 | 8 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 297 | 5 | 0 | 2 | 3.8 | O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818994 | 140287 | 13 | None | 5 | 8 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 297 | 5 | 0 | 2 | 3.8 | O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
46893146 | 61278 | 0 | None | -19 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 475 | 8 | 0 | 5 | 5.0 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771110 | 61278 | 0 | None | -19 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 475 | 8 | 0 | 5 | 5.0 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
137634397 | 155564 | 0 | None | -8 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 8 | 3 | 10 | 2.2 | O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4063145 | 155564 | 0 | None | -8 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 8 | 3 | 10 | 2.2 | O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1 | 10.1016/j.bmc.2017.08.037 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960072u | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960072u | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960072u | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960072u | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960072u | ||
11633170 | 78003 | 0 | None | 63 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 421 | 5 | 0 | 7 | 2.8 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL211118 | 78003 | 0 | None | 63 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 421 | 5 | 0 | 7 | 2.8 | COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1 | 10.1021/jm060166w | ||
45273045 | 194702 | 0 | None | 199 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
CHEMBL562620 | 194702 | 0 | None | 199 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
10361512 | 54154 | 0 | None | 1949 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 365 | 3 | 0 | 5 | 3.5 | Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160932 | 54154 | 0 | None | 1949 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 365 | 3 | 0 | 5 | 3.5 | Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
10267394 | 99923 | 3 | None | 102 | 4 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL28997 | 99923 | 3 | None | 102 | 4 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.7b00151 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.7b00151 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.7b00151 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.7b00151 | ||
10042972 | 106058 | 0 | None | 131 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 341 | 2 | 1 | 4 | 3.7 | O=c1oc2cc(O)ccc2c2c1CN(Cc1ccc(Cl)cc1)CC2 | 10.1021/jm970170v | ||
CHEMBL314095 | 106058 | 0 | None | 131 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 341 | 2 | 1 | 4 | 3.7 | O=c1oc2cc(O)ccc2c2c1CN(Cc1ccc(Cl)cc1)CC2 | 10.1021/jm970170v | ||
21533446 | 69812 | 0 | None | -6 | 10 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL1940403 | 69812 | 0 | None | -6 | 10 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
21527771 | 69813 | 0 | None | -1 | 10 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940404 | 69813 | 0 | None | -1 | 10 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2011.12.019 | ||
71463207 | 83660 | 0 | None | 7 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 4.0 | COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207636 | 83660 | 0 | None | 7 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 4.0 | COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
135524323 | 193755 | 0 | None | 61 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 382 | 5 | 2 | 6 | 1.6 | COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL552268 | 193755 | 0 | None | 61 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 382 | 5 | 2 | 6 | 1.6 | COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1 | 10.1016/j.bmc.2009.05.015 | ||
9863333 | 202662 | 0 | None | -1 | 10 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm980137o | ||
CHEMBL71724 | 202662 | 0 | None | -1 | 10 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm980137o | ||
44340333 | 9571 | 0 | None | 19 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 3.8 | C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL112833 | 9571 | 0 | None | 19 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 3.8 | C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
5029739 | 100359 | 1 | None | 190 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Cc1c(-c2ccc(Cl)cc2)noc1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm970111h | ||
CHEMBL293341 | 100359 | 1 | None | 190 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Cc1c(-c2ccc(Cl)cc2)noc1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm970111h | ||
13869641 | 112904 | 0 | None | -1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 431 | 8 | 0 | 4 | 5.4 | CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318824 | 112904 | 0 | None | -1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 431 | 8 | 0 | 4 | 5.4 | CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
9949442 | 95140 | 0 | None | 56 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1c(-c2ccccc2)cnn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL25772 | 95140 | 0 | None | 56 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.7 | Cc1c(-c2ccccc2)cnn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
5029739 | 100359 | 1 | None | 190 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Cc1c(-c2ccc(Cl)cc2)noc1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm960072u | ||
CHEMBL293341 | 100359 | 1 | None | 190 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Cc1c(-c2ccc(Cl)cc2)noc1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm960072u | ||
71583848 | 87303 | 0 | None | 6 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 5.1 | c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
CHEMBL2336892 | 87303 | 0 | None | 6 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 5.1 | c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
133008 | 2211 | 16 | None | 204 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.7b00151 | ||
3302 | 2211 | 16 | None | 204 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL444309 | 2211 | 16 | None | 204 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.7b00151 | ||
44412468 | 165377 | 0 | None | 61 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 2.6 | c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL425057 | 165377 | 0 | None | 61 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 2.6 | c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
10640530 | 111797 | 0 | None | 190 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 3 | 0 | 4 | 3.7 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(C)cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL329126 | 111797 | 0 | None | 190 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 3 | 0 | 4 | 3.7 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(C)cc1)CC3 | 10.1021/jm970170v | ||
44323962 | 205103 | 0 | None | 7 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 369 | 3 | 1 | 2 | 4.3 | Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL90476 | 205103 | 0 | None | 7 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 369 | 3 | 1 | 2 | 4.3 | Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12 | 10.1016/s0960-894x(98)00474-0 | ||
10807795 | 39033 | 0 | None | 239 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | Cc1ccc(C2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1C | 10.1021/jm990277d | ||
CHEMBL147059 | 39033 | 0 | None | 239 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | Cc1ccc(C2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1C | 10.1021/jm990277d | ||
10664621 | 43712 | 0 | None | 91 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 336 | 3 | 1 | 3 | 3.7 | Cc1ccc(C2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL151286 | 43712 | 0 | None | 91 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 336 | 3 | 1 | 3 | 3.7 | Cc1ccc(C2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
76320592 | 85459 | 0 | None | 9 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 365 | 3 | 1 | 0 | 3.5 | Brc1ccc(-[n+]2cc[n+](Cc3ccccc3)cc2)c2cc[nH]c12 | 10.1007/s00044-012-0055-5 | ||
CHEMBL2298809 | 85459 | 0 | None | 9 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 365 | 3 | 1 | 0 | 3.5 | Brc1ccc(-[n+]2cc[n+](Cc3ccccc3)cc2)c2cc[nH]c12 | 10.1007/s00044-012-0055-5 | ||
10404144 | 203591 | 19 | None | -1 | 10 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm200762g | ||
CHEMBL7927 | 203591 | 19 | None | -1 | 10 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm200762g | ||
155510756 | 168945 | 0 | None | 10 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1ccc(N(Cc2ccccc2F)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4434714 | 168945 | 0 | None | 10 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1ccc(N(Cc2ccccc2F)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
155564308 | 174581 | 0 | None | 12 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 525 | 10 | 2 | 5 | 4.9 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2F)c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4570073 | 174581 | 0 | None | 12 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 525 | 10 | 2 | 5 | 4.9 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2F)c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
44412468 | 165377 | 0 | None | 61 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 2.6 | c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL425057 | 165377 | 0 | None | 61 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 2.6 | c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
44371932 | 119143 | 0 | None | 467 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 354 | 4 | 0 | 5 | 3.1 | O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL346805 | 119143 | 0 | None | 467 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 354 | 4 | 0 | 5 | 3.1 | O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
168268770 | 192170 | 0 | None | 213 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.7 | c1ccc(N2CCN(CCCN3CCCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5169993 | 192170 | 0 | None | 213 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.7 | c1ccc(N2CCN(CCCN3CCCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221238 | 192170 | 0 | None | 213 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 5 | 0 | 3 | 3.7 | c1ccc(N2CCN(CCCN3CCCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
49788870 | 18074 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 341 | 5 | 1 | 3 | 2.7 | Cc1ccc(N2CCN(CCNC(=O)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm100925m | ||
CHEMBL1270322 | 18074 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 341 | 5 | 1 | 3 | 2.7 | Cc1ccc(N2CCN(CCNC(=O)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm100925m | ||
10589218 | 21010 | 0 | None | 23 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL131299 | 21010 | 0 | None | 23 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
44270558 | 164736 | 0 | None | 812 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 3.6 | Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1021/jm0611152 | ||
CHEMBL423247 | 164736 | 0 | None | 812 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 3.6 | Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1021/jm0611152 | ||
44339992 | 108697 | 0 | None | 22 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL321492 | 108697 | 0 | None | 22 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0305669 | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0305669 | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm0305669 | ||
10646459 | 205403 | 0 | None | -1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 433 | 6 | 2 | 4 | 4.2 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2CCCCCC2)C1 | 10.1021/jm9601720 | ||
CHEMBL92199 | 205403 | 0 | None | -1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 433 | 6 | 2 | 4 | 4.2 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2CCCCCC2)C1 | 10.1021/jm9601720 | ||
10589218 | 21010 | 0 | None | 23 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL131299 | 21010 | 0 | None | 23 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccc(OCCCNCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
44412269 | 77746 | 0 | None | 33 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL210232 | 77746 | 0 | None | 33 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
44412269 | 77746 | 0 | None | 33 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL210232 | 77746 | 0 | None | 33 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 349 | 5 | 0 | 6 | 2.6 | COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1 | 10.1016/j.bmcl.2006.02.075 | ||
11724450 | 123330 | 4 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184158 | 123330 | 4 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL362542 | 123330 | 4 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | Cc1cccc(NC(=O)CN2CCN(c3ccccc3C#N)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
44270558 | 164736 | 0 | None | 812 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 3.6 | Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL423247 | 164736 | 0 | None | 812 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 3.6 | Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm000087z | ||
6469693 | 79545 | 17 | None | 158 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1016/j.ejmech.2019.111569 | ||
CHEMBL212631 | 79545 | 17 | None | 158 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1016/j.ejmech.2019.111569 | ||
10854370 | 119101 | 0 | None | 18 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 336 | 3 | 1 | 3 | 3.7 | Cc1ccc(C2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL346398 | 119101 | 0 | None | 18 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 336 | 3 | 1 | 3 | 3.7 | Cc1ccc(C2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
54583897 | 61273 | 0 | None | -1 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 411 | 7 | 0 | 4 | 3.4 | COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771106 | 61273 | 0 | None | -1 | 5 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 411 | 7 | 0 | 4 | 3.4 | COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
6469693 | 79545 | 17 | None | 158 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1021/jm060166w | ||
CHEMBL212631 | 79545 | 17 | None | 158 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 4 | 0 | 5 | 2.7 | COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 | 10.1021/jm060166w | ||
44241718 | 193594 | 0 | None | 70 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 393 | 4 | 1 | 7 | 1.6 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL551199 | 193594 | 0 | None | 70 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 393 | 4 | 1 | 7 | 1.6 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
10249308 | 4834 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1cc(Cl)ccc1OC[C@@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104550 | 4834 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1cc(Cl)ccc1OC[C@@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
15512070 | 52961 | 0 | None | 426 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 342 | 4 | 0 | 5 | 2.6 | Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL159903 | 52961 | 0 | None | 426 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 342 | 4 | 0 | 5 | 2.6 | Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
44372338 | 53563 | 0 | None | 707 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 398 | 4 | 0 | 4 | 3.9 | C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160454 | 53563 | 0 | None | 707 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 398 | 4 | 0 | 4 | 3.9 | C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12 | 10.1016/s0960-894x(01)00814-9 | ||
44278115 | 101049 | 0 | None | 181 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 318 | 4 | 1 | 3 | 3.5 | C=Cc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL29808 | 101049 | 0 | None | 181 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 318 | 4 | 1 | 3 | 3.5 | C=Cc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
137649896 | 156991 | 0 | None | 46 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1ccc(Cl)cc1OC[C@@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL4080034 | 156991 | 0 | None | 46 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1ccc(Cl)cc1OC[C@@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/acs.jmedchem.7b00151 | ||
137649896 | 156991 | 0 | None | 46 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1ccc(Cl)cc1OC[C@@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4080034 | 156991 | 0 | None | 46 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1ccc(Cl)cc1OC[C@@H]1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/acs.jmedchem.8b00265 | ||
14925759 | 157494 | 6 | None | 18 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL4085780 | 157494 | 6 | None | 18 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
14925759 | 157494 | 6 | None | 18 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4085780 | 157494 | 6 | None | 18 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 5 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
44412494 | 77918 | 0 | None | 131 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL210955 | 77918 | 0 | None | 131 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
17475863 | 168219 | 3 | None | 41 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL437490 | 168219 | 3 | None | 41 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm0611152 | ||
44323763 | 204767 | 0 | None | -2 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 3 | 1 | 3 | 3.9 | FC(F)(F)c1nc2c(N3CCN(Cc4ccccc4)CC3)cccc2[nH]1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL88289 | 204767 | 0 | None | -2 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 3 | 1 | 3 | 3.9 | FC(F)(F)c1nc2c(N3CCN(Cc4ccccc4)CC3)cccc2[nH]1 | 10.1016/s0960-894x(98)00474-0 | ||
76309673 | 85462 | 0 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 356 | 3 | 1 | 1 | 3.2 | FC(F)(F)c1nc2c(-[n+]3cc[n+](Cc4ccccc4)cc3)cccc2[nH]1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL2298812 | 85462 | 0 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 356 | 3 | 1 | 1 | 3.2 | FC(F)(F)c1nc2c(-[n+]3cc[n+](Cc4ccccc4)cc3)cccc2[nH]1 | 10.1007/s00044-012-0055-5 | ||
60785 | 204177 | 42 | None | -23 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 425 | 5 | 0 | 4 | 3.7 | O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm0002432 | ||
CHEMBL83894 | 204177 | 42 | None | -23 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 425 | 5 | 0 | 4 | 3.7 | O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm0002432 | ||
155534246 | 171365 | 0 | None | 9 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 10 | 2 | 5 | 4.8 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4470231 | 171365 | 0 | None | 9 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 10 | 2 | 5 | 4.8 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
155566058 | 175127 | 0 | None | 45 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1ccc(N(Cc2ccc(F)cc2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4582096 | 175127 | 0 | None | 45 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1ccc(N(Cc2ccc(F)cc2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
54581964 | 61279 | 0 | None | -10 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 489 | 8 | 0 | 5 | 5.4 | COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771111 | 61279 | 0 | None | -10 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 489 | 8 | 0 | 5 | 5.4 | COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
60785 | 204177 | 42 | None | -23 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 425 | 5 | 0 | 4 | 3.7 | O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL83894 | 204177 | 42 | None | -23 | 7 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 425 | 5 | 0 | 4 | 3.7 | O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.051 | ||
44412494 | 77918 | 0 | None | 131 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL210955 | 77918 | 0 | None | 131 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
17475863 | 168219 | 3 | None | 41 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL437490 | 168219 | 3 | None | 41 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 336 | 4 | 0 | 4 | 3.3 | Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
11372852 | 5059 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 4.7 | CCOc1ccc(Cl)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL105696 | 5059 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 4.7 | CCOc1ccc(Cl)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
49788942 | 18105 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 2.4 | O=C(NCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1021/jm100925m | ||
CHEMBL1270516 | 18105 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 2.4 | O=C(NCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1021/jm100925m | ||
10691523 | 105131 | 0 | None | 34 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(-c2cc(C3CCN(Cc4ccccc4Cl)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL312255 | 105131 | 0 | None | 34 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(-c2cc(C3CCN(Cc4ccccc4Cl)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10837493 | 205375 | 0 | None | 2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 7 | 2 | 4 | 4.5 | COc1cc(NC(=O)C2CCCC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL92030 | 205375 | 0 | None | 2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 7 | 2 | 4 | 4.5 | COc1cc(NC(=O)C2CCCC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
155547128 | 173089 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 399 | 7 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4534703 | 173089 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 399 | 7 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
90644062 | 111542 | 0 | None | 8 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289647 | 111542 | 0 | None | 8 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
49782600 | 17271 | 0 | None | -4 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 369 | 6 | 1 | 3 | 4.4 | Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1257689 | 17271 | 0 | None | -4 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 369 | 6 | 1 | 3 | 4.4 | Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1 | 10.1021/jm100899z | ||
10548329 | 200941 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 4.5 | COc1cc2ccccc2cc1C(=O)NCC1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL61248 | 200941 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 4.5 | COc1cc2ccccc2cc1C(=O)NCC1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
72544566 | 92699 | 0 | None | 5 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 10 | 0 | 6 | 3.1 | COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443009 | 92699 | 0 | None | 5 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 10 | 0 | 6 | 3.1 | COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
25333445 | 77769 | 5 | None | 104 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL210318 | 77769 | 5 | None | 104 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.2 | c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
122191605 | 123203 | 0 | None | 2 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.2 | Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/acsmedchemlett.5b00131 | ||
CHEMBL3622097 | 123203 | 0 | None | 2 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.2 | Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/acsmedchemlett.5b00131 | ||
44376230 | 119482 | 0 | None | 87 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 4 | 0 | 5 | 3.8 | CC(C)(C)c1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL349904 | 119482 | 0 | None | 87 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 4 | 0 | 5 | 3.8 | CC(C)(C)c1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
44372296 | 118982 | 0 | None | 72 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL345357 | 118982 | 0 | None | 72 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1 | 10.1016/s0960-894x(01)00814-9 | ||
71450812 | 78013 | 0 | None | 4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 8 | 1 | 5 | 4.7 | COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL2111525 | 78013 | 0 | None | 4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 8 | 1 | 5 | 4.7 | COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
11849776 | 79362 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 349 | 6 | 0 | 6 | 2.5 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C#N)c1 | 10.1021/jm060279f | ||
CHEMBL211836 | 79362 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 349 | 6 | 0 | 6 | 2.5 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C#N)c1 | 10.1021/jm060279f | ||
667675 | 203422 | 3 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
CHEMBL77969 | 203422 | 3 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
9820085 | 140799 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | Cc1nc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)sc1C | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL38349 | 140799 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | Cc1nc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)sc1C | 10.1016/s0960-894x(98)00252-2 | ||
44340186 | 9569 | 0 | None | 8 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL112831 | 9569 | 0 | None | 8 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(03)00678-4 | ||
44380770 | 165159 | 0 | None | -6 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL424575 | 165159 | 0 | None | -6 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
3156990 | 8046 | 19 | None | 7 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 268 | 4 | 0 | 3 | 3.1 | O=Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL109173 | 8046 | 19 | None | 7 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 268 | 4 | 0 | 3 | 3.1 | O=Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
76441180 | 115237 | 0 | None | -95 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 437 | 9 | 0 | 7 | 4.1 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc(SC)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353913 | 115237 | 0 | None | -95 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 437 | 9 | 0 | 7 | 4.1 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc(SC)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
11658914 | 69897 | 0 | None | -30 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 255 | 5 | 0 | 3 | 3.0 | CCCN(CCC)C1CCn2ncc(Cl)c2C1 | 10.1021/jm0503805 | ||
CHEMBL194099 | 69897 | 0 | None | -30 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 255 | 5 | 0 | 3 | 3.0 | CCCN(CCC)C1CCn2ncc(Cl)c2C1 | 10.1021/jm0503805 | ||
11405182 | 108047 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 5 | 0 | 3 | 4.3 | COc1ccccc1/C=C/C1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL320071 | 108047 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 5 | 0 | 3 | 4.3 | COc1ccccc1/C=C/C1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
56597938 | 3877 | 1 | None | -204 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | ||
7651 | 3877 | 1 | None | -204 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | ||
CHEMBL2165126 | 3877 | 1 | None | -204 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | ||
168275381 | 189676 | 0 | None | 4 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1ncc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5175548 | 189676 | 0 | None | 4 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1ncc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
44415672 | 79764 | 0 | None | -1659 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 531 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL213492 | 79764 | 0 | None | -1659 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 531 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
42605994 | 17692 | 0 | None | 8 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 425 | 5 | 1 | 4 | 3.9 | Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1 | 10.1021/jm100835q | ||
CHEMBL1259071 | 17692 | 0 | None | 8 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 425 | 5 | 1 | 4 | 3.9 | Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1 | 10.1021/jm100835q | ||
9865384 | 172923 | 27 | None | -2344 | 7 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 393 | 5 | 1 | 3 | 3.9 | Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1 | 10.1021/jm100835q | ||
CHEMBL45305 | 172923 | 27 | None | -2344 | 7 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 393 | 5 | 1 | 3 | 3.9 | Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1 | 10.1021/jm100835q | ||
56658008 | 66087 | 0 | None | -52 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 3.9 | COc1ccccc1N1CCN(CCCCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813599 | 66087 | 0 | None | -52 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 3.9 | COc1ccccc1N1CCN(CCCCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851895 | 66087 | 0 | None | -52 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 3.9 | COc1ccccc1N1CCN(CCCCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
10572229 | 120504 | 0 | None | -5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 386 | 4 | 1 | 4 | 3.4 | O=C1NCN(c2ccccc2)C12CCN(Cc1ccn(-c3ccccc3)c1)CC2 | 10.1021/jm00025a013 | ||
CHEMBL356542 | 120504 | 0 | None | -5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 386 | 4 | 1 | 4 | 3.4 | O=C1NCN(c2ccccc2)C12CCN(Cc1ccn(-c3ccccc3)c1)CC2 | 10.1021/jm00025a013 | ||
154725766 | 176071 | 1 | None | -1659 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4527244 | 176071 | 1 | None | -1659 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598000 | 176071 | 1 | None | -1659 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL5094044 | 213689 | 2 | None | -30 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | None | None | None | CN(C)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
10737150 | 107050 | 0 | None | 2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 358 | 7 | 0 | 3 | 4.5 | COc1cccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL318747 | 107050 | 0 | None | 2 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 358 | 7 | 0 | 3 | 4.5 | COc1cccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
127051844 | 140316 | 0 | None | -16 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819427 | 140316 | 0 | None | -16 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
42626172 | 55951 | 0 | None | -1949 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 490 | 8 | 3 | 5 | 3.8 | COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1 | 10.1021/jm501512b | ||
CHEMBL1627314 | 55951 | 0 | None | -1949 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 490 | 8 | 3 | 5 | 3.8 | COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1 | 10.1021/jm501512b | ||
162659314 | 183114 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4762416 | 183114 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4803145 | 183114 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
127051844 | 140316 | 0 | None | -16 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819427 | 140316 | 0 | None | -16 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
168294958 | 191806 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.2 | COc1ccc(CN2CCC[C@H](OCc3cccc(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5207898 | 191806 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.2 | COc1ccc(CN2CCC[C@H](OCc3cccc(F)c3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
11771801 | 79619 | 0 | None | 1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 328 | 5 | 0 | 5 | 2.4 | CO/N=C(\CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL212891 | 79619 | 0 | None | 1 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 328 | 5 | 0 | 5 | 2.4 | CO/N=C(\CN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
162659314 | 183114 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4762416 | 183114 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4803145 | 183114 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
22953120 | 107983 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 4.0 | C[C@H]1c2ccccc2N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)[C@@H]1C | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL319927 | 107983 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 4.0 | C[C@H]1c2ccccc2N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)[C@@H]1C | 10.1016/s0960-894x(02)00655-8 | ||
1212 | 1632 | 45 | None | -77 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
204 | 1632 | 45 | None | -77 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
3372 | 1632 | 45 | None | -77 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
CHEMBL726 | 1632 | 45 | None | -77 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
DB00623 | 1632 | 45 | None | -77 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
168285068 | 190987 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3ncc4ccccn34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5195130 | 190987 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.5 | FC(F)(F)c1cccc(COC2CCN(Cc3ncc4ccccn34)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
154705038 | 176072 | 1 | None | -63 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.2 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4584481 | 176072 | 1 | None | -63 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.2 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598001 | 176072 | 1 | None | -63 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.2 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
127051845 | 140198 | 0 | None | -12 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3817898 | 140198 | 0 | None | -12 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
10551026 | 101146 | 0 | None | -6 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 4.6 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL298875 | 101146 | 0 | None | -6 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 4.6 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
44301054 | 194474 | 0 | None | 21 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL56118 | 194474 | 0 | None | 21 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 266 | 3 | 1 | 3 | 2.2 | N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00004a016 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00004a016 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00004a016 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00004a016 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00004a016 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00043a008 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00043a008 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00043a008 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00043a008 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00043a008 | ||
135418440 | 11963 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 351 | 5 | 1 | 6 | 2.3 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1183663 | 11963 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 351 | 5 | 1 | 6 | 2.3 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL310311 | 11963 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 351 | 5 | 1 | 6 | 2.3 | c1ccc(N2CCN(CCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
3802 | 201334 | 16 | None | 1 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 307 | 0 | 1 | 5 | 2.8 | Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm960084f | ||
CHEMBL63329 | 201334 | 16 | None | 1 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 307 | 0 | 1 | 5 | 2.8 | Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm960084f | ||
21830793 | 91403 | 5 | None | -138 | 46 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | ||
CHEMBL2413154 | 91403 | 5 | None | -138 | 46 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | ||
9930934 | 108150 | 0 | None | 52 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 401 | 5 | 0 | 3 | 3.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2C[C@H]1CF | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL320721 | 108150 | 0 | None | 52 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 401 | 5 | 0 | 3 | 3.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2C[C@H]1CF | 10.1016/s0960-894x(02)00656-x | ||
44336109 | 110461 | 0 | None | 24 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 400 | 4 | 0 | 2 | 5.1 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc(F)cc2Cl)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL326202 | 110461 | 0 | None | 24 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 400 | 4 | 0 | 2 | 5.1 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc(F)cc2Cl)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
2435 | 3533 | 78 | None | -10 | 48 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
60149 | 3533 | 78 | None | -10 | 48 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
98 | 3533 | 78 | None | -10 | 48 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
CHEMBL12713 | 3533 | 78 | None | -10 | 48 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
DB06144 | 3533 | 78 | None | -10 | 48 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
9905246 | 16162 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 322 | 6 | 2 | 4 | 3.6 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1C | 10.1021/jm990266k | ||
CHEMBL122862 | 16162 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 322 | 6 | 2 | 4 | 3.6 | Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1C | 10.1021/jm990266k | ||
155563950 | 174701 | 0 | None | 32 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 569 | 9 | 2 | 4 | 4.7 | O=C(NCCCN1CCN(c2ccc(I)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4572646 | 174701 | 0 | None | 32 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 569 | 9 | 2 | 4 | 4.7 | O=C(NCCCN1CCN(c2ccc(I)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
127028181 | 138919 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 3.1 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(F)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794013 | 138919 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 3.1 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(F)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
57391216 | 69825 | 0 | None | 1 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 332 | 6 | 0 | 5 | 2.9 | Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940416 | 69825 | 0 | None | 1 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 332 | 6 | 0 | 5 | 2.9 | Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57391216 | 69825 | 0 | None | 1 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 332 | 6 | 0 | 5 | 2.9 | Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940416 | 69825 | 0 | None | 1 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 332 | 6 | 0 | 5 | 2.9 | Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
44431490 | 87844 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234826 | 87844 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
44405490 | 132929 | 0 | None | 35 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.4 | O=C(N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL370652 | 132929 | 0 | None | 35 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.4 | O=C(N[C@H]1CCN(Cc2ccc(C(F)(F)F)cc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
137659303 | 158757 | 0 | None | -3 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.8 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4099711 | 158757 | 0 | None | -3 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 9 | 1 | 7 | 2.8 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
22100932 | 202396 | 0 | None | 31 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 374 | 3 | 0 | 3 | 5.9 | Clc1ccc(CN2CC=C(c3nc4cc(Cl)ccc4s3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL70215 | 202396 | 0 | None | 31 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 374 | 3 | 0 | 3 | 5.9 | Clc1ccc(CN2CC=C(c3nc4cc(Cl)ccc4s3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
45273442 | 194777 | 0 | None | 61 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 403 | 3 | 0 | 5 | 4.3 | Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL563078 | 194777 | 0 | None | 61 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 403 | 3 | 0 | 5 | 4.3 | Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
44276075 | 13114 | 0 | None | -4 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 397 | 8 | 0 | 6 | 4.6 | COc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191252 | 13114 | 0 | None | -4 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 397 | 8 | 0 | 6 | 4.6 | COc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL542325 | 13114 | 0 | None | -4 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 397 | 8 | 0 | 6 | 4.6 | COc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
10715225 | 205389 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 386 | 8 | 0 | 4 | 4.5 | COc1cccc(C(=O)CCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL92121 | 205389 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 386 | 8 | 0 | 4 | 4.5 | COc1cccc(C(=O)CCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
44400594 | 133052 | 0 | None | -1 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL371165 | 133052 | 0 | None | -1 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
11948707 | 165614 | 0 | None | -53 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1021/acs.jmedchem.2c00633 | ||
CHEMBL426317 | 165614 | 0 | None | -53 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1021/acs.jmedchem.2c00633 | ||
10616050 | 186064 | 3 | None | 81 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL48807 | 186064 | 3 | None | 81 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
57326583 | 73715 | 0 | None | 1 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 404 | 2 | 0 | 5 | 4.7 | Clc1ccc2c(c1)N=C(N1CCN(Cc3ccccc3)CC1)c1cccnc1O2 | 10.1021/jm2013419 | ||
CHEMBL2022271 | 73715 | 0 | None | 1 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 404 | 2 | 0 | 5 | 4.7 | Clc1ccc2c(c1)N=C(N1CCN(Cc3ccccc3)CC1)c1cccnc1O2 | 10.1021/jm2013419 | ||
127051845 | 140198 | 0 | None | -12 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3817898 | 140198 | 0 | None | -12 | 9 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
44426512 | 85318 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 358 | 5 | 1 | 2 | 4.3 | O=C(c1ccc2ccccc2c1)N1CCC(NCCc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229076 | 85318 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 358 | 5 | 1 | 2 | 4.3 | O=C(c1ccc2ccccc2c1)N1CCC(NCCc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
14665503 | 90803 | 0 | None | -346 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 382 | 7 | 1 | 4 | 2.8 | C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL240106 | 90803 | 0 | None | -346 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 382 | 7 | 1 | 4 | 2.8 | C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
9977478 | 203235 | 2 | None | -3235 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 386 | 6 | 2 | 5 | 2.4 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL76402 | 203235 | 2 | None | -3235 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 386 | 6 | 2 | 5 | 2.4 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
137632607 | 155798 | 0 | None | -56 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 305 | 3 | 2 | 5 | 1.6 | CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4065797 | 155798 | 0 | None | -56 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 305 | 3 | 2 | 5 | 1.6 | CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1021/jm049612a | ||
51354851 | 59858 | 0 | None | -501 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 517 | 17 | 1 | 7 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(OCCOCCOCCF)cc2)CC1 | 10.1021/jm101323b | ||
CHEMBL1688994 | 59858 | 0 | None | -501 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 517 | 17 | 1 | 7 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(OCCOCCOCCF)cc2)CC1 | 10.1021/jm101323b | ||
CHEMBL1739761 | 59858 | 0 | None | -501 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 517 | 17 | 1 | 7 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(OCCOCCOCCF)cc2)CC1 | 10.1021/jm101323b | ||
44578445 | 180997 | 0 | None | -13 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 352 | 6 | 0 | 3 | 4.1 | O=C(CCCN1CC2CCC(C1)N2c1ccccc1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL476933 | 180997 | 0 | None | -13 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 352 | 6 | 0 | 3 | 4.1 | O=C(CCCN1CC2CCC(C1)N2c1ccccc1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(99)00086-4 | ||
137633454 | 156050 | 0 | None | -645 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 645 | 16 | 3 | 10 | 4.4 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4068702 | 156050 | 0 | None | -645 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 645 | 16 | 3 | 10 | 4.4 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1 | 10.1021/acs.jmedchem.7b00363 | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 10.1016/s0960-894x(00)00405-4 | ||
168289523 | 190903 | 0 | None | 5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 422 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5193761 | 190903 | 0 | None | 5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 422 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
10692886 | 53372 | 2 | None | -776 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 409 | 8 | 1 | 5 | 3.6 | COc1ccccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL160296 | 53372 | 2 | None | -776 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 409 | 8 | 1 | 5 | 3.6 | COc1ccccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813590 | 53372 | 2 | None | -776 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 409 | 8 | 1 | 5 | 3.6 | COc1ccccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
4797946 | 169856 | 8 | None | 165 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4448320 | 169856 | 8 | None | 165 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 310 | 4 | 1 | 4 | 2.2 | Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
2247 | 502 | 77 | None | -63 | 41 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
249 | 502 | 77 | None | -63 | 41 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
2603 | 502 | 77 | None | -63 | 41 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
CHEMBL296419 | 502 | 77 | None | -63 | 41 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
DB00637 | 502 | 77 | None | -63 | 41 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
763774 | 91717 | 4 | None | 16 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 292 | 3 | 0 | 3 | 3.7 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420776 | 91717 | 4 | None | 16 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 292 | 3 | 0 | 3 | 3.7 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
42626313 | 55954 | 0 | None | -338 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 423 | 8 | 2 | 6 | 2.7 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm900095y | ||
CHEMBL1627317 | 55954 | 0 | None | -338 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 423 | 8 | 2 | 6 | 2.7 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm900095y | ||
10161526 | 13192 | 0 | None | -40 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 9 | 0 | 5 | 6.1 | c1ccc(C(c2ccccc2)N2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191882 | 13192 | 0 | None | -40 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 9 | 0 | 5 | 6.1 | c1ccc(C(c2ccccc2)N2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL543040 | 13192 | 0 | None | -40 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 9 | 0 | 5 | 6.1 | c1ccc(C(c2ccccc2)N2CCN(CCCCc3cc(-c4cccs4)no3)CC2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
44438232 | 148249 | 3 | None | -4 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 3 | 2 | 3 | 3.7 | OC1(c2ccc(Cl)cc2)CCN(Cc2n[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL394066 | 148249 | 3 | None | -4 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 341 | 3 | 2 | 3 | 3.7 | OC1(c2ccc(Cl)cc2)CCN(Cc2n[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
154705296 | 175820 | 1 | None | -5 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4444691 | 175820 | 1 | None | -5 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595970 | 175820 | 1 | None | -5 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
168275717 | 189625 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3ncc4ccccn34)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5174731 | 189625 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3ncc4ccccn34)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
11133385 | 101716 | 0 | None | -25 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 411 | 6 | 1 | 3 | 4.1 | O=C(NCCCN1CCN(c2ccccc2)CC1)C1c2ccccc2-c2ccccc21 | 10.1021/jm010146o | ||
CHEMBL302796 | 101716 | 0 | None | -25 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 411 | 6 | 1 | 3 | 4.1 | O=C(NCCCN1CCN(c2ccccc2)CC1)C1c2ccccc2-c2ccccc21 | 10.1021/jm010146o | ||
154706703 | 175658 | 1 | None | -38 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 11 | 1 | 2 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4550187 | 175658 | 1 | None | -38 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 11 | 1 | 2 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4594691 | 175658 | 1 | None | -38 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 11 | 1 | 2 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
154706461 | 175774 | 1 | None | -93 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 6.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4470439 | 175774 | 1 | None | -93 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 6.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595600 | 175774 | 1 | None | -93 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 6.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
10613605 | 199263 | 0 | None | -5495 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 292 | 4 | 2 | 2 | 3.7 | c1ccc(CNC[C@H]2CCc3ccc4[nH]ccc4c3O2)cc1 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL60185 | 199263 | 0 | None | -5495 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 292 | 4 | 2 | 2 | 3.7 | c1ccc(CNC[C@H]2CCc3ccc4[nH]ccc4c3O2)cc1 | 10.1016/s0960-894x(01)00778-8 | ||
10617381 | 189094 | 0 | None | -1 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL51536 | 189094 | 0 | None | -1 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
11649431 | 165429 | 0 | None | -91 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 528 | 11 | 1 | 6 | 4.9 | CCCc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
CHEMBL425285 | 165429 | 0 | None | -91 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 528 | 11 | 1 | 6 | 4.9 | CCCc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
10688035 | 104290 | 1 | None | 38 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.9 | c1ccc(CCN2CCC(c3cc(-c4ccccn4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL310819 | 104290 | 1 | None | 38 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.9 | c1ccc(CCN2CCC(c3cc(-c4ccccn4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
4420454 | 55966 | 6 | None | 1 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
CHEMBL162762 | 55966 | 6 | None | 1 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
10616050 | 186064 | 3 | None | 81 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
CHEMBL48807 | 186064 | 3 | None | 81 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
10131111 | 206585 | 0 | None | 18 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 246 | 1 | 0 | 3 | 3.7 | CCn1ncc2c1-c1c(C)sc(C)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL99208 | 206585 | 0 | None | 18 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 246 | 1 | 0 | 3 | 3.7 | CCn1ncc2c1-c1c(C)sc(C)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
10041417 | 26213 | 4 | None | -28 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN(CCc1cccs1)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL135954 | 26213 | 4 | None | -28 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN(CCc1cccs1)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
10740968 | 96275 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCNC(=O)C2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL26426 | 96275 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCNC(=O)C2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
44405451 | 134825 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.4 | O=C(N[C@H]1CCN(Cc2cccc(C(F)(F)F)c2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL372770 | 134825 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 5.4 | O=C(N[C@H]1CCN(Cc2cccc(C(F)(F)F)c2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
9908125 | 118839 | 0 | None | 20 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 384 | 3 | 1 | 3 | 4.7 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1 | 10.1021/jm0009989 | ||
CHEMBL344270 | 118839 | 0 | None | 20 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 384 | 3 | 1 | 3 | 4.7 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1 | 10.1021/jm0009989 | ||
44436597 | 91368 | 0 | None | 1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 5 | 1 | 3 | 4.9 | O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241210 | 91368 | 0 | None | 1 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 5 | 1 | 3 | 4.9 | O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
71734127 | 90626 | 0 | None | -4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm400520c | ||
CHEMBL2397476 | 90626 | 0 | None | -4 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm400520c | ||
46917637 | 67990 | 0 | None | -18 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1053 | 34 | 1 | 15 | 9.7 | CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1 | 10.1021/jm2009919 | ||
CHEMBL1916548 | 67990 | 0 | None | -18 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1053 | 34 | 1 | 15 | 9.7 | CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1 | 10.1021/jm2009919 | ||
10861560 | 45078 | 9 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1ccc(N2CCN(CCNC(=O)c3cccc(OC)c3)CC2)cc1 | 10.1021/jm020952a | ||
CHEMBL152679 | 45078 | 9 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 2.3 | COc1ccc(N2CCN(CCNC(=O)c3cccc(OC)c3)CC2)cc1 | 10.1021/jm020952a | ||
11280344 | 91725 | 0 | None | 2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 3 | 0 | 3 | 5.5 | Clc1cccc(N2CCN(Cc3csc4ccccc34)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420891 | 91725 | 0 | None | 2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 3 | 0 | 3 | 5.5 | Clc1cccc(N2CCN(Cc3csc4ccccc34)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
44283941 | 137403 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 336 | 4 | 1 | 4 | 2.4 | Cc1ccnc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)c1 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL37638 | 137403 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 336 | 4 | 1 | 4 | 2.4 | Cc1ccnc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)c1 | 10.1016/s0960-894x(98)00252-2 | ||
11324794 | 137731 | 0 | None | 7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 324 | 6 | 0 | 5 | 2.6 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL377050 | 137731 | 0 | None | 7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 324 | 6 | 0 | 5 | 2.6 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
90644063 | 111543 | 0 | None | 1 | 10 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL3289648 | 111543 | 0 | None | 1 | 10 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2020.115943 | ||
90644063 | 111543 | 0 | None | -1 | 10 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289648 | 111543 | 0 | None | -1 | 10 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
76328715 | 105891 | 0 | None | -2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115582 | 105891 | 0 | None | -2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139265 | 105891 | 0 | None | -2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
133633 | 2210 | 46 | None | -104 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1021/jm9600712 | ||
177 | 2210 | 46 | None | -104 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1021/jm9600712 | ||
CHEMBL445102 | 2210 | 46 | None | -104 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1021/jm9600712 | ||
44380774 | 119969 | 0 | None | -13 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL354180 | 119969 | 0 | None | -13 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
154704141 | 176105 | 1 | None | -9 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 437 | 11 | 2 | 3 | 5.0 | CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4561808 | 176105 | 1 | None | -9 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 437 | 11 | 2 | 3 | 5.0 | CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598299 | 176105 | 1 | None | -9 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 437 | 11 | 2 | 3 | 5.0 | CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
49783042 | 17509 | 0 | None | -7 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 393 | 7 | 1 | 3 | 4.3 | Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1258495 | 17509 | 0 | None | -7 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 393 | 7 | 1 | 3 | 4.3 | Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1 | 10.1021/jm100899z | ||
57390115 | 68954 | 0 | None | -44 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 455 | 13 | 1 | 6 | 3.4 | CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928120 | 68954 | 0 | None | -44 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 455 | 13 | 1 | 6 | 3.4 | CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/j.bmc.2011.10.063 | ||
44436601 | 91511 | 0 | None | -21 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241424 | 91511 | 0 | None | -21 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1 | 10.1016/j.bmc.2007.08.038 | ||
10830804 | 206185 | 0 | None | 1 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 337 | 5 | 3 | 4 | 1.8 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCNC1 | 10.1021/jm9601720 | ||
CHEMBL96792 | 206185 | 0 | None | 1 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 337 | 5 | 3 | 4 | 1.8 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCNC1 | 10.1021/jm9601720 | ||
2337 | 3205 | 72 | None | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
50 | 3205 | 72 | None | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
5002 | 3205 | 72 | None | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL716 | 3205 | 72 | None | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
DB01224 | 3205 | 72 | None | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
10438027 | 65857 | 0 | None | -645 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 571 | 7 | 1 | 4 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL184383 | 65857 | 0 | None | -645 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 571 | 7 | 1 | 4 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1 | 10.1016/j.bmcl.2004.05.052 | ||
142590710 | 179690 | 0 | None | -3 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 496 | 11 | 2 | 4 | 5.4 | OC(Cc1ccccc1)CN1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4750607 | 179690 | 0 | None | -3 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 496 | 11 | 2 | 4 | 5.4 | OC(Cc1ccccc1)CN1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
118709166 | 112913 | 0 | None | -39 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 944 | 25 | 0 | 8 | 12.9 | O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318838 | 112913 | 0 | None | -39 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 944 | 25 | 0 | 8 | 12.9 | O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
12071089 | 5233 | 0 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 445 | 8 | 0 | 2 | 7.1 | Clc1cccc(C(OC2CC3CCC(C2)N3CCCc2ccccc2)c2ccccc2)c1 | 10.1021/jm010146o | ||
CHEMBL106660 | 5233 | 0 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 445 | 8 | 0 | 2 | 7.1 | Clc1cccc(C(OC2CC3CCC(C2)N3CCCc2ccccc2)c2ccccc2)c1 | 10.1021/jm010146o | ||
122180610 | 121224 | 0 | None | -40 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 430 | 8 | 1 | 6 | 4.0 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4[nH]ccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588981 | 121224 | 0 | None | -40 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 430 | 8 | 1 | 6 | 4.0 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4[nH]ccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
44426513 | 85319 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 372 | 6 | 1 | 2 | 4.7 | O=C(c1ccc2ccccc2c1)N1CCC(NCCCc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229077 | 85319 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 372 | 6 | 1 | 2 | 4.7 | O=C(c1ccc2ccccc2c1)N1CCC(NCCCc2ccccc2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
154706546 | 175872 | 1 | None | -48 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 459 | 12 | 1 | 3 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4452329 | 175872 | 1 | None | -48 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 459 | 12 | 1 | 3 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596339 | 175872 | 1 | None | -48 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 459 | 12 | 1 | 3 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
44431472 | 87054 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1ccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL233403 | 87054 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1ccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
49799713 | 14294 | 0 | None | -177 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 376 | 4 | 2 | 4 | 3.7 | COc1ccc2[nH]cc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173778 | 14294 | 0 | None | -177 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 376 | 4 | 2 | 4 | 3.7 | COc1ccc2[nH]cc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200306 | 14294 | 0 | None | -177 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 376 | 4 | 2 | 4 | 3.7 | COc1ccc2[nH]cc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
162666450 | 181707 | 0 | None | -15 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3ccc(-c4ccccc4)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4783987 | 181707 | 0 | None | -15 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3ccc(-c4ccccc4)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
10225942 | 13043 | 0 | None | -147 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 451 | 9 | 0 | 4 | 6.1 | c1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1190732 | 13043 | 0 | None | -147 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 451 | 9 | 0 | 4 | 6.1 | c1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL541524 | 13043 | 0 | None | -147 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 451 | 9 | 0 | 4 | 6.1 | c1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
45379370 | 7442 | 0 | None | -21 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 | 10.1021/jm901291r | ||
CHEMBL1087301 | 7442 | 0 | None | -21 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 | 10.1021/jm901291r | ||
16744003 | 92126 | 0 | None | -43 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 453 | 10 | 0 | 7 | 4.2 | CCOc1ccccc1N1CCN(CCC[C@H]2CC(c3ccc(OC)c(OC)c3)=NO2)CC1 | 10.1016/j.ejmech.2006.12.030 | ||
CHEMBL243225 | 92126 | 0 | None | -43 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 453 | 10 | 0 | 7 | 4.2 | CCOc1ccccc1N1CCN(CCC[C@H]2CC(c3ccc(OC)c(OC)c3)=NO2)CC1 | 10.1016/j.ejmech.2006.12.030 | ||
162666450 | 181707 | 0 | None | -15 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3ccc(-c4ccccc4)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4783987 | 181707 | 0 | None | -15 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3ccc(-c4ccccc4)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
17755866 | 142352 | 1 | None | -162 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm070388+ | ||
CHEMBL389356 | 142352 | 1 | None | -162 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm070388+ | ||
9929581 | 16337 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.4 | CC(C)(C)c1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1 | 10.1021/jm990266k | ||
CHEMBL123663 | 16337 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 376 | 3 | 0 | 4 | 4.4 | CC(C)(C)c1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1 | 10.1021/jm990266k | ||
118719810 | 115238 | 0 | None | -100 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccccc1N1CCN(CCCCCc2cn(-c3ccc(SC)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353914 | 115238 | 0 | None | -100 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccccc1N1CCN(CCCCCc2cn(-c3ccc(SC)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
44438222 | 93058 | 0 | None | -11 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 349 | 3 | 1 | 2 | 4.9 | N#CC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246230 | 93058 | 0 | None | -11 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 349 | 3 | 1 | 2 | 4.9 | N#CC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
10425024 | 7057 | 4 | None | -40 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 302 | 3 | 1 | 2 | 3.8 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cc1 | 10.1021/jm950721m | ||
CHEMBL108531 | 7057 | 4 | None | -40 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 302 | 3 | 1 | 2 | 3.8 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cc1 | 10.1021/jm950721m | ||
9794644 | 106797 | 0 | None | 2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 232 | 0 | 0 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1cn(C)nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL317078 | 106797 | 0 | None | 2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 232 | 0 | 0 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1cn(C)nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
127051863 | 140283 | 0 | None | 1 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3o2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818940 | 140283 | 0 | None | 1 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3o2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
10425024 | 7057 | 4 | None | -40 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 302 | 3 | 1 | 2 | 3.8 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL108531 | 7057 | 4 | None | -40 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 302 | 3 | 1 | 2 | 3.8 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
44438219 | 167112 | 0 | None | -12 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 339 | 3 | 2 | 2 | 4.3 | NC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL430198 | 167112 | 0 | None | -12 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 339 | 3 | 2 | 2 | 4.3 | NC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
10688036 | 103668 | 0 | None | 38 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.9 | c1ccc(CCN2CCC(c3cc(-c4cccnc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL309460 | 103668 | 0 | None | 38 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.9 | c1ccc(CCN2CCC(c3cc(-c4cccnc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
10735344 | 104379 | 0 | None | 52 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.4 | c1ccc(CCN2CCN(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL310985 | 104379 | 0 | None | 52 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.4 | c1ccc(CCN2CCN(c3cc(-c4ccccc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
10381810 | 203463 | 0 | None | -1 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL7828 | 203463 | 0 | None | -1 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
44381118 | 57265 | 0 | None | 4 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 387 | 7 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL166587 | 57265 | 0 | None | 4 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 387 | 7 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
44356064 | 116046 | 0 | None | 4 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 329 | 7 | 0 | 3 | 4.6 | CCCN(CCc1cccs1)[C@@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
CHEMBL336295 | 116046 | 0 | None | 4 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 329 | 7 | 0 | 3 | 4.6 | CCCN(CCc1cccs1)[C@@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
90644063 | 111543 | 0 | None | 1 | 10 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL3289648 | 111543 | 0 | None | 1 | 10 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2020.115943 | ||
90644063 | 111543 | 0 | None | -1 | 10 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289648 | 111543 | 0 | None | -1 | 10 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
49783040 | 17508 | 0 | None | -4 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1 | 10.1021/jm100899z | ||
CHEMBL1258494 | 17508 | 0 | None | -4 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1 | 10.1021/jm100899z | ||
72544789 | 92700 | 0 | None | 9 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 9 | 0 | 7 | 1.6 | COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443010 | 92700 | 0 | None | 9 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 9 | 0 | 7 | 1.6 | COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
11417962 | 4905 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 392 | 7 | 0 | 6 | 3.5 | COc1ccc([N+](=O)[O-])cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104873 | 4905 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 392 | 7 | 0 | 6 | 3.5 | COc1ccc([N+](=O)[O-])cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
10832341 | 206117 | 0 | None | 218 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 7 | 1 | 4 | 3.3 | COc1cccc(CNCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL96462 | 206117 | 0 | None | 218 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 7 | 1 | 4 | 3.3 | COc1cccc(CNCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
168278360 | 192245 | 0 | None | 8 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 7 | 0 | 3 | 4.0 | O=C1CCc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5188796 | 192245 | 0 | None | 8 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 7 | 0 | 3 | 4.0 | O=C1CCc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221749 | 192245 | 0 | None | 8 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 7 | 0 | 3 | 4.0 | O=C1CCc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
11089541 | 83966 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 354 | 6 | 1 | 5 | 2.0 | COc1cccc(C(=O)NCCN2CCN(c3cc(C)ccn3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL2112905 | 83966 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 354 | 6 | 1 | 5 | 2.0 | COc1cccc(C(=O)NCCN2CCN(c3cc(C)ccn3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL2219567 | 83966 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 354 | 6 | 1 | 5 | 2.0 | COc1cccc(C(=O)NCCN2CCN(c3cc(C)ccn3)CC2)c1 | 10.1021/jm020952a | ||
9883554 | 164802 | 0 | None | 141 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL423659 | 164802 | 0 | None | 141 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
10071413 | 83556 | 0 | None | -41 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 431 | 8 | 2 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3[nH]2)CC1 | 10.1021/jm0611152 | ||
CHEMBL220700 | 83556 | 0 | None | -41 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 431 | 8 | 2 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3[nH]2)CC1 | 10.1021/jm0611152 | ||
35295787 | 85314 | 4 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 358 | 5 | 1 | 2 | 4.3 | O=C(NC1CCN(CCc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229021 | 85314 | 4 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 358 | 5 | 1 | 2 | 4.3 | O=C(NC1CCN(CCc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
44336571 | 4762 | 0 | None | 30 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 316 | 4 | 0 | 4 | 3.8 | N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL104201 | 4762 | 0 | None | 30 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 316 | 4 | 0 | 4 | 3.8 | N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(99)00540-5 | ||
52937680 | 60845 | 0 | None | -416 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 466 | 10 | 1 | 4 | 5.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1 | 10.1021/jm101639t | ||
CHEMBL1765632 | 60845 | 0 | None | -416 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 466 | 10 | 1 | 4 | 5.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1 | 10.1021/jm101639t | ||
9838216 | 201498 | 1 | None | -12 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 266 | 6 | 2 | 2 | 3.3 | c1ccc(CNCCOc2cccc3[nH]ccc23)cc1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL64283 | 201498 | 1 | None | -12 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 266 | 6 | 2 | 2 | 3.3 | c1ccc(CNCCOc2cccc3[nH]ccc23)cc1 | 10.1016/s0960-894x(99)00434-5 | ||
130431279 | 175311 | 0 | None | -102 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 254 | 3 | 1 | 3 | 2.3 | CCc1cc(Cl)c(OC)c(N2CCNCC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4586327 | 175311 | 0 | None | -102 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 254 | 3 | 1 | 3 | 2.3 | CCc1cc(Cl)c(OC)c(N2CCNCC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
44264741 | 203034 | 0 | None | 1 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 340 | 2 | 0 | 4 | 3.0 | O=C(c1cnn2ccccc12)N1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7441 | 203034 | 0 | None | 1 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 340 | 2 | 0 | 4 | 3.0 | O=C(c1cnn2ccccc12)N1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(98)00692-1 | ||
10300403 | 13618 | 0 | None | -120 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 496 | 10 | 0 | 6 | 6.0 | O=[N+]([O-])c1cccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1195074 | 13618 | 0 | None | -120 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 496 | 10 | 0 | 6 | 6.0 | O=[N+]([O-])c1cccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL553810 | 13618 | 0 | None | -120 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 496 | 10 | 0 | 6 | 6.0 | O=[N+]([O-])c1cccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c1 | 10.1016/s0960-894x(02)00179-8 | ||
122180575 | 121213 | 0 | None | -21 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 441 | 8 | 0 | 6 | 4.7 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4ccccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588920 | 121213 | 0 | None | -21 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 441 | 8 | 0 | 6 | 4.7 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4ccccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
24060 | 119150 | 7 | None | -6 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 264 | 5 | 0 | 2 | 3.4 | CN(C)CCC(C#N)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
CHEMBL346898 | 119150 | 7 | None | -6 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 264 | 5 | 0 | 2 | 3.4 | CN(C)CCC(C#N)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
154725813 | 175952 | 1 | None | -89 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4568916 | 175952 | 1 | None | -89 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597047 | 175952 | 1 | None | -89 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
44276079 | 13688 | 0 | None | -11 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 9 | 0 | 6 | 4.6 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4F)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1195587 | 13688 | 0 | None | -11 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 9 | 0 | 6 | 4.6 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4F)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL554897 | 13688 | 0 | None | -11 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 9 | 0 | 6 | 4.6 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4F)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
56664952 | 66052 | 0 | None | -33 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 423 | 9 | 1 | 5 | 4.0 | COc1ccccc1N1CCN(CCCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813598 | 66052 | 0 | None | -33 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 423 | 9 | 1 | 5 | 4.0 | COc1ccccc1N1CCN(CCCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851753 | 66052 | 0 | None | -33 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 423 | 9 | 1 | 5 | 4.0 | COc1ccccc1N1CCN(CCCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
9928332 | 96732 | 4 | None | -117 | 9 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 349 | 6 | 0 | 3 | 5.0 | COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 | 10.1021/jm049619s | ||
CHEMBL268258 | 96732 | 4 | None | -117 | 9 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 349 | 6 | 0 | 3 | 5.0 | COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 | 10.1021/jm049619s | ||
CHEMBL5083186 | 213078 | 0 | None | -1202 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | None | None | None | CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2CC1CC1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.1c00611 | ||||
44336172 | 5289 | 0 | None | 16 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 476 | 6 | 0 | 5 | 2.3 | CN(C)S(=O)(=O)c1ccc2c(c1)CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106917 | 5289 | 0 | None | 16 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 476 | 6 | 0 | 5 | 2.3 | CN(C)S(=O)(=O)c1ccc2c(c1)CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44336194 | 107053 | 0 | None | 16 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 5 | 0 | 4 | 3.8 | CSc1ccc2c(c1)CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL318760 | 107053 | 0 | None | 16 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 5 | 0 | 4 | 3.8 | CSc1ccc2c(c1)CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
122181334 | 121362 | 0 | None | -954 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 442 | 7 | 2 | 5 | 3.4 | Cc1ccc(Cl)c(N2CCN(CCCCNC(=O)c3ccc4oc(=O)[nH]c4c3)CC2)c1 | 10.1021/jm501512b | ||
CHEMBL3590086 | 121362 | 0 | None | -954 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 442 | 7 | 2 | 5 | 3.4 | Cc1ccc(Cl)c(N2CCN(CCCCNC(=O)c3ccc4oc(=O)[nH]c4c3)CC2)c1 | 10.1021/jm501512b | ||
130431317 | 172381 | 0 | None | -2454 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 455 | 8 | 2 | 5 | 4.0 | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4517102 | 172381 | 0 | None | -2454 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 455 | 8 | 2 | 5 | 4.0 | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
164628177 | 188026 | 0 | None | -25 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 7 | 1 | 5 | 2.8 | CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4875079 | 188026 | 0 | None | -25 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 7 | 1 | 5 | 2.8 | CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL5029038 | 188026 | 0 | None | -25 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 7 | 1 | 5 | 2.8 | CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
10404657 | 97619 | 0 | None | -28 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL273241 | 97619 | 0 | None | -28 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
11213037 | 136579 | 0 | None | -851 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 8 | 1 | 3 | 5.3 | O=C(NCCCCN1CCN(c2ccccc2Cl)CC1)c1ccc(-c2ccccc2)cc1 | 10.1021/jm0611152 | ||
CHEMBL374749 | 136579 | 0 | None | -851 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 8 | 1 | 3 | 5.3 | O=C(NCCCCN1CCN(c2ccccc2Cl)CC1)c1ccc(-c2ccccc2)cc1 | 10.1021/jm0611152 | ||
71618702 | 142850 | 0 | None | -5 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 400 | 5 | 0 | 4 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1 | nan | ||
CHEMBL3897835 | 142850 | 0 | None | -5 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 400 | 5 | 0 | 4 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1 | nan | ||
90644070 | 111549 | 0 | None | -3 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 5 | 0 | 3 | 5.0 | Clc1ccc(N2C[C@H]3C[C@@H]2CN3CCCc2cc3ccccc3o2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289654 | 111549 | 0 | None | -3 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 5 | 0 | 3 | 5.0 | Clc1ccc(N2C[C@H]3C[C@@H]2CN3CCCc2cc3ccccc3o2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
164628177 | 188026 | 0 | None | -25 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 7 | 1 | 5 | 2.8 | CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4875079 | 188026 | 0 | None | -25 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 7 | 1 | 5 | 2.8 | CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL5029038 | 188026 | 0 | None | -25 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 366 | 7 | 1 | 5 | 2.8 | CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
44394636 | 66584 | 0 | None | 63 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL186558 | 66584 | 0 | None | 63 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44214765 | 165247 | 0 | None | 208 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 5 | 2 | 3 | 3.9 | Nc1cccc(-c2ccc(C(=O)NC3CCN(Cc4ccccc4)C3)cc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL424808 | 165247 | 0 | None | 208 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 5 | 2 | 3 | 3.9 | Nc1cccc(-c2ccc(C(=O)NC3CCN(Cc4ccccc4)C3)cc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
219050 | 3321 | 21 | None | -58 | 21 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 10.1021/jm950721m | ||
52 | 3321 | 21 | None | -58 | 21 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 10.1021/jm950721m | ||
CHEMBL431367 | 3321 | 21 | None | -58 | 21 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 10.1021/jm950721m | ||
13015797 | 204181 | 0 | None | 1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 400 | 6 | 0 | 5 | 3.7 | COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2 | 10.1021/jm960084f | ||
CHEMBL83915 | 204181 | 0 | None | 1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 400 | 6 | 0 | 5 | 3.7 | COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2 | 10.1021/jm960084f | ||
9888555 | 165052 | 11 | None | -208 | 8 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm100899z | ||
CHEMBL424294 | 165052 | 11 | None | -208 | 8 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm100899z | ||
136056636 | 111296 | 0 | None | -28 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
CHEMBL3287404 | 111296 | 0 | None | -28 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
118709159 | 112906 | 0 | None | -3 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 832 | 17 | 0 | 8 | 9.7 | O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318831 | 112906 | 0 | None | -3 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 832 | 17 | 0 | 8 | 9.7 | O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
11156017 | 5057 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 7 | 0 | 4 | 4.6 | CCOc1cc(I)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL105686 | 5057 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 7 | 0 | 4 | 4.6 | CCOc1cc(I)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
9927411 | 201364 | 0 | None | 4 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 0 | 1 | 5 | 3.1 | CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm0104825 | ||
CHEMBL63576 | 201364 | 0 | None | 4 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 327 | 0 | 1 | 5 | 3.1 | CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm0104825 | ||
9797200 | 118466 | 0 | None | 109 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 321 | 4 | 1 | 3 | 2.7 | O=C1NC(CCN2CCN(c3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL34239 | 118466 | 0 | None | 109 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 321 | 4 | 1 | 3 | 2.7 | O=C1NC(CCN2CCN(c3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00252-2 | ||
45482153 | 196361 | 0 | None | -5 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 502 | 9 | 1 | 7 | 3.9 | COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1 | 10.1016/j.bmc.2009.06.041 | ||
CHEMBL574030 | 196361 | 0 | None | -5 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 502 | 9 | 1 | 7 | 3.9 | COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1 | 10.1016/j.bmc.2009.06.041 | ||
44380785 | 120290 | 0 | None | -7 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL355566 | 120290 | 0 | None | -7 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
10404657 | 97619 | 0 | None | -28 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL273241 | 97619 | 0 | None | -28 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 3.1 | O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.05.053 | ||
90644064 | 111544 | 0 | None | -1 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 383 | 7 | 0 | 4 | 5.0 | Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289649 | 111544 | 0 | None | -1 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 383 | 7 | 0 | 4 | 5.0 | Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57390117 | 68957 | 0 | None | -16 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 455 | 13 | 1 | 6 | 3.2 | CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928123 | 68957 | 0 | None | -16 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 455 | 13 | 1 | 6 | 3.2 | CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2011.10.063 | ||
127047221 | 139400 | 0 | None | 1 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 319 | 8 | 4 | 6 | 1.8 | COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3799593 | 139400 | 0 | None | 1 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 319 | 8 | 4 | 6 | 1.8 | COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1 | 10.1016/j.bmc.2016.04.028 | ||
57400562 | 68976 | 0 | None | -2 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 469 | 14 | 1 | 6 | 3.6 | CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928247 | 68976 | 0 | None | -2 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 469 | 14 | 1 | 6 | 3.6 | CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1 | 10.1016/j.bmc.2011.10.063 | ||
71086389 | 159861 | 0 | None | 1 | 2 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 339 | 6 | 0 | 5 | 2.2 | c1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL4111289 | 159861 | 0 | None | 1 | 2 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 339 | 6 | 0 | 5 | 2.2 | c1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
10811814 | 205732 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 9 | 1 | 4 | 4.1 | COc1cccc(C(=O)NCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL94265 | 205732 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 9 | 1 | 4 | 4.1 | COc1cccc(C(=O)NCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
154704941 | 176053 | 1 | None | -7 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 470 | 11 | 0 | 6 | 5.8 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4578364 | 176053 | 1 | None | -7 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 470 | 11 | 0 | 6 | 5.8 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597877 | 176053 | 1 | None | -7 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 470 | 11 | 0 | 6 | 5.8 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
10811814 | 205732 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 9 | 1 | 4 | 4.1 | COc1cccc(C(=O)NCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL94265 | 205732 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 9 | 1 | 4 | 4.1 | COc1cccc(C(=O)NCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
168281091 | 190477 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(C)cc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5187429 | 190477 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccc(C)cc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
182600 | 118239 | 2 | None | -2 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 3.9 | O=C(CCCN1CCN2c3ccccc3CCC2C1)c1ccc(F)cc1 | 10.1021/jm049031l | ||
CHEMBL341774 | 118239 | 2 | None | -2 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 3.9 | O=C(CCCN1CCN2c3ccccc3CCC2C1)c1ccc(F)cc1 | 10.1021/jm049031l | ||
10229397 | 13145 | 0 | None | -123 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 511 | 11 | 0 | 6 | 6.1 | COc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191467 | 13145 | 0 | None | -123 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 511 | 11 | 0 | 6 | 6.1 | COc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL542571 | 13145 | 0 | None | -123 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 511 | 11 | 0 | 6 | 6.1 | COc1ccc(-c2cc(CCCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
44438215 | 92977 | 5 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | OC1(c2ccc(Cl)cc2)CCCN(Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL245816 | 92977 | 5 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | OC1(c2ccc(Cl)cc2)CCCN(Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2006.10.076 | ||
9906978 | 42466 | 1 | None | 1 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
CHEMBL150161 | 42466 | 1 | None | 1 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
49798812 | 14205 | 0 | None | -16 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 3 | 1 | 3 | 4.5 | OC1(c2ccc(I)cc2)CCN(Cc2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1170456 | 14205 | 0 | None | -16 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 3 | 1 | 3 | 4.5 | OC1(c2ccc(I)cc2)CCN(Cc2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1199971 | 14205 | 0 | None | -16 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 3 | 1 | 3 | 4.5 | OC1(c2ccc(I)cc2)CCN(Cc2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
9906978 | 42466 | 1 | None | 1 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL150161 | 42466 | 1 | None | 1 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
23290944 | 81414 | 0 | None | -323 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 6 | 0 | 4 | 3.8 | O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164350 | 81414 | 0 | None | -323 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 6 | 0 | 4 | 3.8 | O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
51353989 | 59893 | 0 | None | -112 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 481 | 11 | 1 | 5 | 5.1 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1ccc(-c2ccsc2)cc1 | 10.1021/jm101323b | ||
CHEMBL1689006 | 59893 | 0 | None | -112 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 481 | 11 | 1 | 5 | 5.1 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1ccc(-c2ccsc2)cc1 | 10.1021/jm101323b | ||
CHEMBL1739963 | 59893 | 0 | None | -112 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 481 | 11 | 1 | 5 | 5.1 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1ccc(-c2ccsc2)cc1 | 10.1021/jm101323b | ||
9908071 | 201315 | 0 | None | 3 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 383 | 3 | 0 | 3 | 3.4 | CN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL63209 | 201315 | 0 | None | 3 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 383 | 3 | 0 | 3 | 3.4 | CN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
21533446 | 69812 | 0 | None | -6 | 10 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940403 | 69812 | 0 | None | -6 | 10 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2011.12.019 | ||
90181059 | 159684 | 0 | None | -1 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 382 | 6 | 0 | 5 | 2.4 | COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL4109801 | 159684 | 0 | None | -1 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 382 | 6 | 0 | 5 | 2.4 | COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1 | nan | ||
44339879 | 171716 | 0 | None | 4 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL447476 | 171716 | 0 | None | 4 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
11792324 | 204016 | 0 | None | 8 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CC[C@H]3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
CHEMBL82591 | 204016 | 0 | None | 8 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.5 | COc1ccc(N2CCN(CC[C@H]3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
10851078 | 197709 | 1 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 290 | 3 | 1 | 1 | 4.5 | c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm9600712 | ||
CHEMBL59103 | 197709 | 1 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 290 | 3 | 1 | 1 | 4.5 | c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm9600712 | ||
10644771 | 106605 | 0 | None | -61 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 401 | 8 | 1 | 4 | 3.7 | COc1cccc(C(=O)NCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL315879 | 106605 | 0 | None | -61 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 401 | 8 | 1 | 4 | 3.7 | COc1cccc(C(=O)NCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
44335761 | 108734 | 0 | None | 8 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 379 | 5 | 0 | 4 | 2.8 | COc1ccccc1CN1CCN(CC(=O)N2c3ccccc3CC2C)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL321734 | 108734 | 0 | None | 8 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 379 | 5 | 0 | 4 | 2.8 | COc1ccccc1CN1CCN(CC(=O)N2c3ccccc3CC2C)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
10851078 | 197709 | 1 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 290 | 3 | 1 | 1 | 4.5 | c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm0002432 | ||
CHEMBL59103 | 197709 | 1 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 290 | 3 | 1 | 1 | 4.5 | c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm0002432 | ||
145988693 | 166613 | 0 | None | 5 | 17 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 7 | 1 | 3 | 7.1 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL4291048 | 166613 | 0 | None | 5 | 17 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 7 | 1 | 3 | 7.1 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
45268293 | 194461 | 0 | None | 20 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 4 | 1 | 7 | 1.4 | Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL561123 | 194461 | 0 | None | 20 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 4 | 1 | 7 | 1.4 | Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
10644771 | 106605 | 0 | None | -61 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 401 | 8 | 1 | 4 | 3.7 | COc1cccc(C(=O)NCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL315879 | 106605 | 0 | None | -61 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 401 | 8 | 1 | 4 | 3.7 | COc1cccc(C(=O)NCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
44301157 | 101236 | 0 | None | 79 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 5 | 0 | 3 | 4.4 | O=C(OCC1CCN(Cc2ccccc2)CC1)c1ccc(Cl)cc1 | 10.1021/jm960017l | ||
CHEMBL299479 | 101236 | 0 | None | 79 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 5 | 0 | 3 | 4.4 | O=C(OCC1CCN(Cc2ccccc2)CC1)c1ccc(Cl)cc1 | 10.1021/jm960017l | ||
10595646 | 197677 | 0 | None | 63 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 7 | 0 | 3 | 5.5 | COc1cc2ccccc2cc1OCCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL59075 | 197677 | 0 | None | 63 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 7 | 0 | 3 | 5.5 | COc1cc2ccccc2cc1OCCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
42266974 | 98838 | 8 | None | 100 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 2.6 | CC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL282008 | 98838 | 8 | None | 100 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 2.6 | CC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
621 | 906 | 64 | None | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
83 | 906 | 64 | None | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
11185987 | 79938 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 310 | 5 | 1 | 5 | 2.5 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL214314 | 79938 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 310 | 5 | 1 | 5 | 2.5 | O/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
16094666 | 81315 | 2 | None | 52 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL216393 | 81315 | 2 | None | 52 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.8 | Cc1cccc(NC(=O)CN2CCC(c3ccccc3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL5089655 | 213446 | 0 | None | 2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | N#CC(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
10089203 | 41112 | 0 | None | -1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 3.1 | CNc1nc(Cl)c(Sc2ccccc2)c(N2CCN(C)CC2)n1 | 10.1016/s0960-894x(01)00167-6 | ||
CHEMBL14899 | 41112 | 0 | None | -1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 3.1 | CNc1nc(Cl)c(Sc2ccccc2)c(N2CCN(C)CC2)n1 | 10.1016/s0960-894x(01)00167-6 | ||
233199 | 155071 | 15 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 286 | 3 | 0 | 2 | 3.7 | Clc1ccc(N2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL404570 | 155071 | 15 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 286 | 3 | 0 | 2 | 3.7 | Clc1ccc(N2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2007.12.026 | ||
44380717 | 119843 | 0 | None | 10 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 7 | 2 | 4 | 3.6 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL353087 | 119843 | 0 | None | 10 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 7 | 2 | 4 | 3.6 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
23642427 | 91367 | 0 | None | -549 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 430 | 7 | 1 | 4 | 2.7 | C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL241169 | 91367 | 0 | None | -549 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 430 | 7 | 1 | 4 | 2.7 | C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC | 10.1016/j.bmc.2007.07.017 | ||
57395340 | 68958 | 0 | None | -28 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 469 | 14 | 1 | 6 | 3.6 | CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928124 | 68958 | 0 | None | -28 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 469 | 14 | 1 | 6 | 3.6 | CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2011.10.063 | ||
11774358 | 5084 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 6 | 0 | 4 | 4.6 | COc1ccc(C(F)(F)F)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL105836 | 5084 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 415 | 6 | 0 | 4 | 4.6 | COc1ccc(C(F)(F)F)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
12049520 | 100596 | 6 | None | 9 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 319 | 4 | 0 | 4 | 3.7 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL294780 | 100596 | 6 | None | 9 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 319 | 4 | 0 | 4 | 3.7 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
10449136 | 205698 | 0 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL94067 | 205698 | 0 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
10014924 | 106787 | 0 | None | -16 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm0503805 | ||
CHEMBL316983 | 106787 | 0 | None | -16 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm0503805 | ||
10014924 | 106787 | 0 | None | -16 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm049269+ | ||
CHEMBL316983 | 106787 | 0 | None | -16 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm049269+ | ||
18519 | 67318 | 26 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 287 | 2 | 5 | 5 | 1.9 | Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1O | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL19068 | 67318 | 26 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 287 | 2 | 5 | 5 | 1.9 | Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1O | 10.1016/S0960-894X(97)00194-7 | ||
134155116 | 150436 | 0 | None | -158 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3958215 | 150436 | 0 | None | -158 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | ||
34 | 467 | 117 | None | -117 | 51 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | ||
155547197 | 173023 | 0 | None | -208 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4533305 | 173023 | 0 | None | -208 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
134155116 | 150436 | 0 | None | -158 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3958215 | 150436 | 0 | None | -158 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 309 | 3 | 0 | 2 | 3.6 | O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
11540842 | 83953 | 0 | None | -29 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 514 | 10 | 1 | 6 | 4.7 | Cc1c(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
CHEMBL221897 | 83953 | 0 | None | -29 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 514 | 10 | 1 | 6 | 4.7 | Cc1c(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
9872676 | 77826 | 0 | None | -6309 | 17 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | ||
CHEMBL210514 | 77826 | 0 | None | -6309 | 17 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | ||
11522476 | 74174 | 0 | None | -4 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 | 10.1021/jm050846j | ||
CHEMBL202924 | 74174 | 0 | None | -4 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 | 10.1021/jm050846j | ||
71453386 | 81409 | 0 | None | -17 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 6 | 0 | 3 | 5.7 | O=C(c1cccc2ccccc12)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164345 | 81409 | 0 | None | -17 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 6 | 0 | 3 | 5.7 | O=C(c1cccc2ccccc12)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
4987774 | 14244 | 1 | None | -14 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.7 | OC1(c2ccc(Br)cc2)CCN(Cc2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1172210 | 14244 | 1 | None | -14 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.7 | OC1(c2ccc(Br)cc2)CCN(Cc2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200151 | 14244 | 1 | None | -14 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.7 | OC1(c2ccc(Br)cc2)CCN(Cc2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
10801925 | 11519 | 1 | None | -9 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@H](CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
CHEMBL1180675 | 11519 | 1 | None | -9 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@H](CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
CHEMBL138016 | 11519 | 1 | None | -9 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@H](CNCc1ccccc1)CC2 | 10.1021/jm9703653 | ||
44330340 | 106989 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 275 | 2 | 1 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1c(CN(C)C)n[nH]c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL318415 | 106989 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 275 | 2 | 1 | 3 | 3.3 | Cc1sc(C)c2c1CCCc1c(CN(C)C)n[nH]c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
46227317 | 198479 | 0 | None | -14 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 265 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL596448 | 198479 | 0 | None | -14 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 265 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | ||
155547197 | 173023 | 0 | None | -208 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4533305 | 173023 | 0 | None | -208 | 7 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.4 | O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
11633816 | 13014 | 2 | None | -48 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4OC)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1190494 | 13014 | 2 | None | -48 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4OC)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL541025 | 13014 | 2 | None | -48 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4OC)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
137640511 | 156524 | 0 | None | 14 | 8 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 286 | 4 | 0 | 2 | 3.1 | CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4074104 | 156524 | 0 | None | 14 | 8 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 286 | 4 | 0 | 2 | 3.1 | CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
23363843 | 109183 | 0 | None | 4 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 383 | 5 | 0 | 4 | 2.7 | O=C1C(=O)N(CCN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL322567 | 109183 | 0 | None | 4 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 383 | 5 | 0 | 4 | 2.7 | O=C1C(=O)N(CCN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
44370058 | 119189 | 0 | None | 19 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 2.9 | COc1ccc(N2CCN(CCc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL347291 | 119189 | 0 | None | 19 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 2.9 | COc1ccc(N2CCN(CCc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(99)00025-6 | ||
10357628 | 13810 | 0 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 303 | 2 | 0 | 2 | 5.0 | CCN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL1196433 | 13810 | 0 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 303 | 2 | 0 | 2 | 5.0 | CCN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL556969 | 13810 | 0 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 303 | 2 | 0 | 2 | 5.0 | CCN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
10474613 | 162740 | 0 | None | 54 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 7 | 1 | 3 | 4.5 | OC(COc1cccc2ccccc12)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL418758 | 162740 | 0 | None | 54 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 7 | 1 | 3 | 4.5 | OC(COc1cccc2ccccc12)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
10176799 | 206521 | 0 | None | 17 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 218 | 0 | 0 | 3 | 2.9 | Cc1sc(C)c2c1CCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL98830 | 206521 | 0 | None | 17 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 218 | 0 | 0 | 3 | 2.9 | Cc1sc(C)c2c1CCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
127029389 | 138913 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793984 | 138913 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3cccc(F)c3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
44431488 | 87647 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccccc1CN1CCC(NC(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234647 | 87647 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccccc1CN1CCC(NC(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2006.12.106 | ||
22100933 | 202587 | 4 | None | 22 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 4.5 | Clc1ccc2[nH]c(C3=CCN(Cc4ccccc4)CC3)nc2c1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL71324 | 202587 | 4 | None | 22 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 4.5 | Clc1ccc2[nH]c(C3=CCN(Cc4ccccc4)CC3)nc2c1 | 10.1016/S0960-894X(97)00402-2 | ||
44371980 | 53652 | 0 | None | 7 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 514 | 6 | 0 | 6 | 4.9 | Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160536 | 53652 | 0 | None | 7 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 514 | 6 | 0 | 6 | 4.9 | Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c01327 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c01327 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c01327 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/acs.jmedchem.1c01327 | ||
11220975 | 102519 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm0305669 | ||
CHEMBL306711 | 102519 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm0305669 | ||
5311346 | 202453 | 22 | None | -19 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL1256778 | 202453 | 22 | None | -19 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL70565 | 202453 | 22 | None | -19 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/acs.jmedchem.9b00702 | ||
10665101 | 101055 | 0 | None | 22 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL298166 | 101055 | 0 | None | 22 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1016/j.bmcl.2005.02.012 | ||
9883554 | 164802 | 0 | None | 141 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL423659 | 164802 | 0 | None | 141 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
10498972 | 117955 | 1 | None | 63 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.2 | Cc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL341225 | 117955 | 1 | None | 63 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.2 | Cc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
44269825 | 42267 | 0 | None | -4 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 368 | 3 | 0 | 5 | 4.0 | Cc1nc(Cl)c(Sc2ccc(Cl)cc2)c(N2CCN(C)CC2)n1 | 10.1016/s0960-894x(01)00167-6 | ||
CHEMBL14998 | 42267 | 0 | None | -4 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 368 | 3 | 0 | 5 | 4.0 | Cc1nc(Cl)c(Sc2ccc(Cl)cc2)c(N2CCN(C)CC2)n1 | 10.1016/s0960-894x(01)00167-6 | ||
CHEMBL4434865 | 212175 | 1 | None | 23 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | c1ccc(Cc2cn(C3CCN(Cc4ccccc4)CC3)nn2)cc1 | 10.1016/j.bmc.2022.116851 | ||||
25141534 | 55942 | 0 | None | -1698 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL1627305 | 55942 | 0 | None | -1698 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1016/j.bmc.2015.01.017 | ||
25141534 | 55942 | 0 | None | -1698 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/ml500006v | ||
CHEMBL1627305 | 55942 | 0 | None | -1698 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/ml500006v | ||
137637428 | 155695 | 0 | None | -3 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 250 | 1 | 1 | 5 | 0.9 | CN1CCN(c2ccc(O)c3c2OCCO3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4064759 | 155695 | 0 | None | -3 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 250 | 1 | 1 | 5 | 0.9 | CN1CCN(c2ccc(O)c3c2OCCO3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL5076359 | 212661 | 0 | None | -77 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | None | None | None | COc1cccc(C(=CCNCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2cccc(OC)c2)c1 | 10.1021/acs.jmedchem.1c00611 | ||||
181743 | 177997 | 3 | None | -131 | 22 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | ||
CHEMBL467094 | 177997 | 3 | None | -131 | 22 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | ||
1605 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
1728 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
22267 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
4095 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
4586 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
5458 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
643985 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
CHEMBL159659 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
CHEMBL651 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
DB00333 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
DB13515 | 2462 | 21 | None | -8511 | 9 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.3 | CCC(=O)C(c1ccccc1)(c1ccccc1)CC(N(C)C)C | 10.1021/acs.jmedchem.1c00611 | ||
11488451 | 201460 | 0 | None | -12 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 3.3 | COc1cc2c(cc1OC)CN(CCNC(=O)c1cc(Br)cc(OC)c1OC)CC2 | 10.1016/j.bmcl.2003.09.083 | ||
CHEMBL64176 | 201460 | 0 | None | -12 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 3.3 | COc1cc2c(cc1OC)CN(CCNC(=O)c1cc(Br)cc(OC)c1OC)CC2 | 10.1016/j.bmcl.2003.09.083 | ||
10782097 | 113765 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 322 | 7 | 1 | 4 | 3.4 | CCN(CCNCc1ccc2ccc(=O)oc2c1)c1ccccc1 | 10.1021/jm990266k | ||
CHEMBL333057 | 113765 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 322 | 7 | 1 | 4 | 3.4 | CCN(CCNCc1ccc2ccc(=O)oc2c1)c1ccccc1 | 10.1021/jm990266k | ||
511484 | 4278 | 66 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 252 | 3 | 0 | 2 | 3.0 | c1ccc(CN2CCN(c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL101032 | 4278 | 66 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 252 | 3 | 0 | 2 | 3.0 | c1ccc(CN2CCN(c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
142590755 | 182844 | 0 | None | -3 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 496 | 11 | 2 | 4 | 5.4 | OC(CNC1CCN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4798638 | 182844 | 0 | None | -3 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 496 | 11 | 2 | 4 | 5.4 | OC(CNC1CCN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 | 10.1016/j.ejmech.2020.112674 | ||
10058787 | 116094 | 0 | None | -407 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 205 | 3 | 2 | 2 | 2.2 | CCCNC1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL336652 | 116094 | 0 | None | -407 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 205 | 3 | 2 | 2 | 2.2 | CCCNC1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
122180611 | 121225 | 0 | None | -39 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 442 | 8 | 0 | 7 | 4.1 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4ncccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588982 | 121225 | 0 | None | -39 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 442 | 8 | 0 | 7 | 4.1 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4ncccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
134154680 | 154025 | 0 | None | -38 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 416 | 7 | 0 | 5 | 5.3 | COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3959919 | 154025 | 0 | None | -38 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 416 | 7 | 0 | 5 | 5.3 | COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991166 | 154025 | 0 | None | -38 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 416 | 7 | 0 | 5 | 5.3 | COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
11613105 | 83654 | 0 | None | -39 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 12 | 1 | 8 | 3.4 | COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(c4ccccc4OC)CC3)c2C)cc1 | 10.1021/jm0611152 | ||
CHEMBL220754 | 83654 | 0 | None | -39 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 12 | 1 | 8 | 3.4 | COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(c4ccccc4OC)CC3)c2C)cc1 | 10.1021/jm0611152 | ||
44339992 | 108697 | 0 | None | 22 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL321492 | 108697 | 0 | None | 22 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10665101 | 101055 | 0 | None | 22 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1021/jm970021c | ||
CHEMBL298166 | 101055 | 0 | None | 22 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 3.2 | Cc1cccc(C(=O)NCN2CCN(c3ccccc3Cl)CC2)c1 | 10.1021/jm970021c | ||
9883554 | 164802 | 0 | None | 141 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
CHEMBL423659 | 164802 | 0 | None | 141 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.1 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1021/jm970021c | ||
10498972 | 117955 | 1 | None | 63 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.2 | Cc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1021/jm970422s | ||
CHEMBL341225 | 117955 | 1 | None | 63 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.2 | Cc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1021/jm970422s | ||
44336313 | 9154 | 1 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccccc2F)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL110712 | 9154 | 1 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccccc2F)CC1 | 10.1016/s0960-894x(02)00656-x | ||
9883552 | 15410 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 3 | 0 | 4 | 3.1 | O=c1ccc2ccc(CN3CCN(c4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL122140 | 15410 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 320 | 3 | 0 | 4 | 3.1 | O=c1ccc2ccc(CN3CCN(c4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
127031497 | 138961 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794469 | 138961 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
145969667 | 164413 | 0 | None | -1 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4225278 | 164413 | 0 | None | -1 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
118709751 | 113042 | 0 | None | -20 | 10 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL3321792 | 113042 | 0 | None | -20 | 10 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F | 10.1016/j.bmcl.2014.07.018 | ||
21219144 | 92908 | 0 | None | 40 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 3.2 | c1ccc(CN2CCC(n3nnc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL24539 | 92908 | 0 | None | 40 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 3.2 | c1ccc(CN2CCC(n3nnc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
10939167 | 9409 | 0 | None | -7 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 443 | 9 | 1 | 4 | 4.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm101639t | ||
CHEMBL112065 | 9409 | 0 | None | -7 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 443 | 9 | 1 | 4 | 4.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm101639t | ||
CHEMBL129483 | 9409 | 0 | None | -7 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 443 | 9 | 1 | 4 | 4.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm101639t | ||
44332566 | 107873 | 0 | None | 8 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 276 | 6 | 2 | 3 | 3.1 | Nc1cc(OCCNCc2ccccc2)ccc1Cl | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL319816 | 107873 | 0 | None | 8 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 276 | 6 | 2 | 3 | 3.1 | Nc1cc(OCCNCc2ccccc2)ccc1Cl | 10.1016/s0960-894x(98)00014-6 | ||
56681927 | 66064 | 1 | None | -5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 3.9 | COc1cc(C)ccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813593 | 66064 | 1 | None | -5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 3.9 | COc1cc(C)ccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851787 | 66064 | 1 | None | -5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 3.9 | COc1cc(C)ccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
11221906 | 79501 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(C)c(C)c1 | 10.1021/jm060279f | ||
CHEMBL212444 | 79501 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(C)c(C)c1 | 10.1021/jm060279f | ||
76328715 | 105891 | 0 | None | -2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115582 | 105891 | 0 | None | -2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139265 | 105891 | 0 | None | -2 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
9841608 | 99957 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 355 | 4 | 1 | 3 | 3.3 | O=C1NC(CCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL290351 | 99957 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 355 | 4 | 1 | 3 | 3.3 | O=C1NC(CCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00252-2 | ||
10449136 | 205698 | 0 | None | 1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
CHEMBL94067 | 205698 | 0 | None | 1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
10449136 | 205698 | 0 | None | 1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL94067 | 205698 | 0 | None | 1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 327 | 1 | 0 | 1 | 5.6 | CC(C)=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
137640836 | 156464 | 0 | None | -31 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 434 | 7 | 1 | 8 | 3.1 | O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2o1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4073330 | 156464 | 0 | None | -31 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 434 | 7 | 1 | 8 | 3.1 | O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2o1 | 10.1021/acs.jmedchem.7b00363 | ||
17987129 | 110931 | 2 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 323 | 5 | 2 | 2 | 3.2 | O=C(NCc1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL327339 | 110931 | 2 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 323 | 5 | 2 | 2 | 3.2 | O=C(NCc1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
13014681 | 203022 | 0 | None | -891 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 323 | 1 | 0 | 1 | 5.1 | CN1CCC(C2=Cc3cc(Cl)ccc3Cc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL7430 | 203022 | 0 | None | -891 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 323 | 1 | 0 | 1 | 5.1 | CN1CCC(C2=Cc3cc(Cl)ccc3Cc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
44323876 | 204856 | 0 | None | -22 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 330 | 1 | 0 | 2 | 4.6 | CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL88870 | 204856 | 0 | None | -22 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 330 | 1 | 0 | 2 | 4.6 | CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
10568740 | 15381 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 334 | 4 | 0 | 4 | 3.1 | O=c1ccc2ccc(CN3CCN(Cc4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL121967 | 15381 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 334 | 4 | 0 | 4 | 3.1 | O=c1ccc2ccc(CN3CCN(Cc4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
15508239 | 6179 | 0 | None | 2 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 336 | 3 | 0 | 2 | 4.6 | C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL108160 | 6179 | 0 | None | 2 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 336 | 3 | 0 | 2 | 4.6 | C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
44582678 | 180992 | 0 | None | -18 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 401 | 9 | 1 | 4 | 4.3 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
CHEMBL476839 | 180992 | 0 | None | -18 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 401 | 9 | 1 | 4 | 4.3 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
17756101 | 98132 | 1 | None | -79 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | ||
CHEMBL276778 | 98132 | 1 | None | -79 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | ||
134154680 | 154025 | 0 | None | -38 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 416 | 7 | 0 | 5 | 5.3 | COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3959919 | 154025 | 0 | None | -38 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 416 | 7 | 0 | 5 | 5.3 | COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991166 | 154025 | 0 | None | -38 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 416 | 7 | 0 | 5 | 5.3 | COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2 | 10.1016/j.bmc.2016.09.019 | ||
9904074 | 110139 | 1 | None | -190 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 289 | 5 | 1 | 4 | 3.5 | CCCN(CCC)C1Cc2cc3nc(N)sc3cc2C1 | 10.1021/jm000087z | ||
CHEMBL325710 | 110139 | 1 | None | -190 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 289 | 5 | 1 | 4 | 3.5 | CCCN(CCC)C1Cc2cc3nc(N)sc3cc2C1 | 10.1021/jm000087z | ||
44330692 | 111875 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 202 | 0 | 1 | 2 | 2.8 | Cc1oc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL329503 | 111875 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 202 | 0 | 1 | 2 | 2.8 | Cc1oc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
10357631 | 7907 | 0 | None | -38 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cn1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL109063 | 7907 | 0 | None | -38 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cn1 | 10.1016/j.bmcl.2005.02.012 | ||
155557792 | 174113 | 0 | None | -69 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 419 | 9 | 1 | 5 | 4.0 | COc1ccccc1OCCNCC1OCCOC1(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2019.02.056 | ||
CHEMBL4559278 | 174113 | 0 | None | -69 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 419 | 9 | 1 | 5 | 4.0 | COc1ccccc1OCCNCC1OCCOC1(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2019.02.056 | ||
44438218 | 93016 | 0 | None | -2 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 338 | 3 | 1 | 1 | 5.4 | CC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246020 | 93016 | 0 | None | -2 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 338 | 3 | 1 | 1 | 5.4 | CC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
168296363 | 191919 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1ncc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5209344 | 191919 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.0 | Cn1ncc2cc(CN3CCC(OCc4ccc(F)c(F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
17756212 | 85941 | 1 | None | -36 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | ||
CHEMBL231374 | 85941 | 1 | None | -36 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | ||
7077 | 66625 | 24 | None | -10 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/jm049720x | ||
CHEMBL186720 | 66625 | 24 | None | -10 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/jm049720x | ||
CHEMBL3925724 | 66625 | 24 | None | -10 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/jm049720x | ||
15034333 | 4185 | 1 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1ccc(OCCNCc2ccccc2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL100461 | 4185 | 1 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1ccc(OCCNCc2ccccc2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
44591042 | 176237 | 0 | None | -15 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 380 | 4 | 2 | 2 | 4.9 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCc1c[nH]c2ccccc12 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL460854 | 176237 | 0 | None | -15 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 380 | 4 | 2 | 2 | 4.9 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCc1c[nH]c2ccccc12 | 10.1016/j.bmc.2008.12.054 | ||
10357631 | 7907 | 0 | None | -38 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cn1 | 10.1021/jm950721m | ||
CHEMBL109063 | 7907 | 0 | None | -38 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cn1 | 10.1021/jm950721m | ||
CHEMBL5087543 | 213333 | 0 | None | -46 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | None | None | None | CN(C)C(=O)C(CCNCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
134153539 | 153968 | 0 | None | -6 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 6.0 | Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3971383 | 153968 | 0 | None | -6 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 6.0 | Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990611 | 153968 | 0 | None | -6 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 6.0 | Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
10017758 | 13073 | 0 | None | -3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 301 | 2 | 0 | 1 | 4.8 | CCN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL1190993 | 13073 | 0 | None | -3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 301 | 2 | 0 | 1 | 4.8 | CCN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL542029 | 13073 | 0 | None | -3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 301 | 2 | 0 | 1 | 4.8 | CCN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
45482169 | 196161 | 0 | None | 1 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 559 | 12 | 1 | 8 | 4.5 | O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmc.2009.06.041 | ||
CHEMBL572379 | 196161 | 0 | None | 1 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 559 | 12 | 1 | 8 | 4.5 | O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1016/j.bmc.2009.06.041 | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
155548336 | 173168 | 0 | None | 14 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 507 | 8 | 2 | 4 | 4.5 | O=C(NCCN1CCN(c2ccc(Br)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4536530 | 173168 | 0 | None | 14 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 507 | 8 | 2 | 4 | 4.5 | O=C(NCCN1CCN(c2ccc(Br)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
127029391 | 138818 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1cc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792907 | 138818 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1cc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)ccc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
118709750 | 113041 | 0 | None | -2 | 9 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL3321791 | 113041 | 0 | None | -2 | 9 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1 | 10.1016/j.bmcl.2014.07.018 | ||
16105548 | 82286 | 0 | None | -75 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 9 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1 | 10.1021/jm0611152 | ||
CHEMBL217964 | 82286 | 0 | None | -75 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 9 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1 | 10.1021/jm0611152 | ||
CHEMBL221652 | 82286 | 0 | None | -75 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 462 | 9 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1 | 10.1021/jm0611152 | ||
10073194 | 12854 | 0 | None | -10 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 465 | 11 | 0 | 7 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3ccc(OC)c(OC)c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1189407 | 12854 | 0 | None | -10 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 465 | 11 | 0 | 7 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3ccc(OC)c(OC)c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL538723 | 12854 | 0 | None | -10 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 465 | 11 | 0 | 7 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3ccc(OC)c(OC)c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
118714552 | 114029 | 0 | None | 97 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 3.2 | Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335555 | 114029 | 0 | None | 97 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 3.2 | Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
10430935 | 105314 | 1 | None | 2 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 397 | 10 | 1 | 2 | 6.0 | Fc1ccc(C(SCCNCCCc2ccccc2)c2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.6b01373 | ||
CHEMBL3126735 | 105314 | 1 | None | 2 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 397 | 10 | 1 | 2 | 6.0 | Fc1ccc(C(SCCNCCCc2ccccc2)c2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.6b01373 | ||
155536720 | 171621 | 0 | None | 77 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4473652 | 171621 | 0 | None | 77 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 4 | 1 | 3 | 3.9 | Cc1cccc(NC(=O)CN2CCN(c3cccc4ccccc34)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
57399432 | 70121 | 0 | None | 2 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.5 | Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946254 | 70121 | 0 | None | 2 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.5 | Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
57399432 | 70121 | 0 | None | 2 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.5 | Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL1946254 | 70121 | 0 | None | 2 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.5 | Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
137635734 | 155571 | 0 | None | 61 | 8 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 7 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4063176 | 155571 | 0 | None | 61 | 8 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 7 | 0 | 3 | 3.2 | O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
44336552 | 110852 | 0 | None | 18 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 316 | 4 | 0 | 4 | 3.8 | N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL326864 | 110852 | 0 | None | 18 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 316 | 4 | 0 | 4 | 3.8 | N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
10573099 | 206093 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 400 | 9 | 0 | 4 | 4.9 | COc1cccc(C(=O)CCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL96322 | 206093 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 400 | 9 | 0 | 4 | 4.9 | COc1cccc(C(=O)CCCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
164628883 | 185869 | 0 | None | -14 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 427 | 6 | 2 | 5 | 3.8 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4876546 | 185869 | 0 | None | -14 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 427 | 6 | 2 | 5 | 3.8 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
11652518 | 165379 | 0 | None | 16 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 311 | 3 | 0 | 5 | 2.2 | Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL425064 | 165379 | 0 | None | 16 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 311 | 3 | 0 | 5 | 2.2 | Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1 | 10.1021/jm060166w | ||
16277250 | 110003 | 5 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CC(C(=O)N1CCc2ccccc21)N1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL324867 | 110003 | 5 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CC(C(=O)N1CCc2ccccc21)N1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44426510 | 85317 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 386 | 7 | 1 | 2 | 5.1 | O=C(NC1CCN(CCCCc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229025 | 85317 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 386 | 7 | 1 | 2 | 5.1 | O=C(NC1CCN(CCCCc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
134153539 | 153968 | 0 | None | -6 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 6.0 | Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3971383 | 153968 | 0 | None | -6 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 6.0 | Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990611 | 153968 | 0 | None | -6 | 9 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 5 | 0 | 3 | 6.0 | Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
11384207 | 82939 | 0 | None | -165 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 405 | 7 | 1 | 3 | 4.3 | O=C(NCCCCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1021/jm0611152 | ||
CHEMBL219274 | 82939 | 0 | None | -165 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 405 | 7 | 1 | 3 | 4.3 | O=C(NCCCCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1021/jm0611152 | ||
11569619 | 136040 | 0 | None | -66 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 4.3 | Cc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
CHEMBL373873 | 136040 | 0 | None | -66 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 4.3 | Cc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
11670421 | 168230 | 0 | None | -10 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 492 | 11 | 1 | 8 | 3.0 | COc1ccc(Cn2nnc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2C)cc1 | 10.1021/jm0611152 | ||
CHEMBL437525 | 168230 | 0 | None | -10 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 492 | 11 | 1 | 8 | 3.0 | COc1ccc(Cn2nnc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2C)cc1 | 10.1021/jm0611152 | ||
90644072 | 111547 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 340 | 4 | 0 | 3 | 4.5 | Clc1ccc(N2CCN(CCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289652 | 111547 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 340 | 4 | 0 | 3 | 4.5 | Clc1ccc(N2CCN(CCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
44438186 | 146675 | 3 | None | -7 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | OC1(c2ccccc2Cl)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL392822 | 146675 | 3 | None | -7 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | OC1(c2ccccc2Cl)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
11016342 | 102331 | 0 | None | -281 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 481 | 8 | 1 | 3 | 6.0 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccc2)cc1 | 10.1021/jm020952a | ||
CHEMBL305362 | 102331 | 0 | None | -281 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 481 | 8 | 1 | 3 | 6.0 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccc2)cc1 | 10.1021/jm020952a | ||
76311262 | 105812 | 0 | None | -660 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 11 | 2 | 5 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(OCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3133779 | 105812 | 0 | None | -660 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 11 | 2 | 5 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(OCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3139053 | 105812 | 0 | None | -660 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 11 | 2 | 5 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(OCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
71061724 | 145019 | 0 | None | -2 | 5 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 386 | 5 | 0 | 4 | 3.0 | O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21 | nan | ||
CHEMBL3915107 | 145019 | 0 | None | -2 | 5 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 386 | 5 | 0 | 4 | 3.0 | O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21 | nan | ||
56664950 | 66292 | 1 | None | -11 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 9 | 1 | 6 | 3.6 | COc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)c(OC)c1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813592 | 66292 | 1 | None | -11 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 9 | 1 | 6 | 3.6 | COc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)c(OC)c1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1852737 | 66292 | 1 | None | -11 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 9 | 1 | 6 | 3.6 | COc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)c(OC)c1 | 10.1016/j.bmc.2011.04.021 | ||
155195311 | 173775 | 0 | None | -208 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4551160 | 173775 | 0 | None | -208 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
44330554 | 206481 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 218 | 0 | 0 | 3 | 2.9 | Cc1sc(C)c2c1CCc1cn(C)nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL98578 | 206481 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 218 | 0 | 0 | 3 | 2.9 | Cc1sc(C)c2c1CCc1cn(C)nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
17756102 | 85717 | 0 | None | -123 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 309 | 1 | 0 | 2 | 4.1 | COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | ||
CHEMBL231171 | 85717 | 0 | None | -123 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 309 | 1 | 0 | 2 | 4.1 | COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | ||
11512263 | 83949 | 0 | None | -89 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 544 | 11 | 1 | 7 | 4.7 | COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2C)cc1 | 10.1021/jm0611152 | ||
CHEMBL221866 | 83949 | 0 | None | -89 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 544 | 11 | 1 | 7 | 4.7 | COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2C)cc1 | 10.1021/jm0611152 | ||
154726529 | 175871 | 1 | None | -26 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 459 | 12 | 1 | 3 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4467486 | 175871 | 1 | None | -26 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 459 | 12 | 1 | 3 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596338 | 175871 | 1 | None | -26 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 459 | 12 | 1 | 3 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
10469437 | 56247 | 1 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 289 | 1 | 0 | 2 | 4.6 | CN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL163863 | 56247 | 1 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 289 | 1 | 0 | 2 | 4.6 | CN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
135398737 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
38 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
722 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
CHEMBL42 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
DB00363 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
30740059 | 107182 | 1 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 6 | 0 | 5 | 2.8 | COc1ccc(OC)c(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)c1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL319043 | 107182 | 1 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 6 | 0 | 5 | 2.8 | COc1ccc(OC)c(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)c1 | 10.1016/s0960-894x(02)00656-x | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm960268u | ||
44335813 | 5287 | 0 | None | 28 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.9 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106914 | 5287 | 0 | None | 28 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.9 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
127030612 | 138800 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.7 | Clc1ccc(CN2CCO[C@H](COc3cccc(Cl)n3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792725 | 138800 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 3.7 | Clc1ccc(CN2CCO[C@H](COc3cccc(Cl)n3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
10115074 | 120162 | 0 | None | 7 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 453 | 4 | 0 | 4 | 4.1 | COc1ccc(Cl)cc1CN1CCN(C2CCc3cccc4c3N(C2=O)C(C)(C)C4)CC1 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL354699 | 120162 | 0 | None | 7 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 453 | 4 | 0 | 4 | 4.1 | COc1ccc(Cl)cc1CN1CCN(C2CCc3cccc4c3N(C2=O)C(C)(C)C4)CC1 | 10.1016/s0960-894x(02)01056-9 | ||
25070416 | 111293 | 0 | None | -4 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nn2ccccc12 | 10.1021/jm5004039 | ||
CHEMBL3287401 | 111293 | 0 | None | -4 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nn2ccccc12 | 10.1021/jm5004039 | ||
44426508 | 85315 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.8 | CC(c1ccccc1)N1CCC(NC(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229023 | 85315 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.8 | CC(c1ccccc1)N1CCC(NC(=O)c2ccc3ccccc3c2)CC1 | 10.1016/j.bmcl.2006.12.096 | ||
118709174 | 112923 | 0 | None | -10 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 946 | 23 | 0 | 10 | 9.6 | CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318847 | 112923 | 0 | None | -10 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 946 | 23 | 0 | 10 | 9.6 | CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
10641637 | 118275 | 0 | None | 19 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1 | 10.1021/jm0009989 | ||
CHEMBL342001 | 118275 | 0 | None | 19 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1 | 10.1021/jm0009989 | ||
11290928 | 5234 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 345 | 6 | 0 | 3 | 4.2 | COc1ccccc1CCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL106665 | 5234 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 345 | 6 | 0 | 3 | 4.2 | COc1ccccc1CCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
44372198 | 48875 | 0 | None | 199 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 420 | 4 | 0 | 4 | 5.1 | Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL156198 | 48875 | 0 | None | 199 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 420 | 4 | 0 | 4 | 5.1 | Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
162671033 | 183173 | 0 | None | 3 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4793296 | 183173 | 0 | None | 3 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4803797 | 183173 | 0 | None | 3 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
44264622 | 96695 | 5 | None | 22 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 327 | 3 | 0 | 5 | 2.7 | Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL267853 | 96695 | 5 | None | 22 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 327 | 3 | 0 | 5 | 2.7 | Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
122177644 | 120699 | 0 | None | -239 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | ||
CHEMBL3577345 | 120699 | 0 | None | -239 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | ||
44335569 | 5090 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 4.7 | CCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2Cl)CCO1 | 10.1021/jm031111m | ||
CHEMBL105894 | 5090 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 4.7 | CCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2Cl)CCO1 | 10.1021/jm031111m | ||
44319370 | 106564 | 0 | None | 1 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 3.8 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL315564 | 106564 | 0 | None | 1 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 3.8 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1 | 10.1016/s0960-894x(01)00484-x | ||
13014680 | 97993 | 1 | None | -407 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 324 | 1 | 0 | 2 | 4.0 | CN1CCN(C2=Cc3cc(Cl)ccc3Cc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL275696 | 97993 | 1 | None | -407 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 324 | 1 | 0 | 2 | 4.0 | CN1CCN(C2=Cc3cc(Cl)ccc3Cc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
1499 | 2060 | 43 | None | -18 | 17 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | 10.1016/j.bmc.2016.04.028 | ||
3779 | 2060 | 43 | None | -18 | 17 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | 10.1016/j.bmc.2016.04.028 | ||
536 | 2060 | 43 | None | -18 | 17 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL434 | 2060 | 43 | None | -18 | 17 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | 10.1016/j.bmc.2016.04.028 | ||
DB01064 | 2060 | 43 | None | -18 | 17 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | 10.1016/j.bmc.2016.04.028 | ||
71462266 | 81419 | 0 | None | -34 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 6 | 0 | 3 | 5.7 | O=C(c1ccc2ccccc2c1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164355 | 81419 | 0 | None | -34 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 6 | 0 | 3 | 5.7 | O=C(c1ccc2ccccc2c1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
154706513 | 176012 | 1 | None | -4 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 480 | 12 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4440698 | 176012 | 1 | None | -4 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 480 | 12 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597532 | 176012 | 1 | None | -4 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 480 | 12 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | ||
10803829 | 11500 | 1 | None | -288 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)O[C@H](CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
CHEMBL1180636 | 11500 | 1 | None | -288 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)O[C@H](CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
CHEMBL135725 | 11500 | 1 | None | -288 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)O[C@H](CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
57587922 | 170946 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 235 | 3 | 1 | 4 | 1.8 | CCCN1CC(c2ccc(N)nc2)OC[C@@H]1C | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4464060 | 170946 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 235 | 3 | 1 | 4 | 1.8 | CCCN1CC(c2ccc(N)nc2)OC[C@@H]1C | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL5077114 | 212711 | 0 | None | -2137 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.1c00611 | ||||
155195486 | 169120 | 0 | None | -14 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@@H]1C[C@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4437740 | 169120 | 0 | None | -14 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@@H]1C[C@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
16094677 | 82923 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 325 | 4 | 1 | 3 | 2.4 | Cc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
CHEMBL219185 | 82923 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 325 | 4 | 1 | 3 | 2.4 | Cc1cccc(NC(=O)CN2CCC(c3cccc[n+]3[O-])CC2)c1 | 10.1021/jm060662k | ||
9929629 | 101646 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 377 | 4 | 0 | 3 | 3.5 | CCN1C(=O)C(N2CCN(Cc3ccc(C)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL302340 | 101646 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 377 | 4 | 0 | 3 | 3.5 | CCN1C(=O)C(N2CCN(Cc3ccc(C)cc3)CC2)CCc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
44332581 | 4315 | 0 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1ccccc1OCCNCc1ccccc1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL101285 | 4315 | 0 | None | -6 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1ccccc1OCCNCc1ccccc1 | 10.1016/s0960-894x(98)00014-6 | ||
71658075 | 89970 | 0 | None | -194 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 4.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386614 | 89970 | 0 | None | -194 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 4.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
109030343 | 170293 | 1 | None | 15 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4454068 | 170293 | 1 | None | 15 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
122180568 | 121206 | 0 | None | -102 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 441 | 8 | 0 | 6 | 4.6 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc4ccccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588913 | 121206 | 0 | None | -102 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 441 | 8 | 0 | 6 | 4.6 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc4ccccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
44431492 | 87848 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 345 | 4 | 1 | 3 | 3.6 | O=C(NC1CCN(Cc2ccccn2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234827 | 87848 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 345 | 4 | 1 | 3 | 3.6 | O=C(NC1CCN(Cc2ccccn2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
11637457 | 72740 | 1 | None | -8 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1021/jm050846j | ||
CHEMBL201093 | 72740 | 1 | None | -8 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1021/jm050846j | ||
163322331 | 191617 | 3 | None | 8 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 4.5 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(F)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5204764 | 191617 | 3 | None | 8 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 4.5 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(F)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
44438230 | 93124 | 3 | None | -194 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 354 | 3 | 2 | 2 | 4.6 | Cc1[nH]c2ccccc2c1CN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246439 | 93124 | 3 | None | -194 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 354 | 3 | 2 | 2 | 4.6 | Cc1[nH]c2ccccc2c1CN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
10021193 | 66031 | 0 | None | 199 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 356 | 5 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL185156 | 66031 | 0 | None | 199 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 356 | 5 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44214766 | 66730 | 0 | None | 275 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL187236 | 66730 | 0 | None | 275 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
11559589 | 122192 | 0 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL360424 | 122192 | 0 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
72901200 | 119272 | 21 | None | 154 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
CHEMBL3480577 | 119272 | 21 | None | 154 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
9995379 | 106467 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 2.5 | O=C1Cc2c(cccc2N2CCN(Cc3ccccc3)CC2)N1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL314952 | 106467 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 2.5 | O=C1Cc2c(cccc2N2CCN(Cc3ccccc3)CC2)N1 | 10.1016/s0960-894x(98)00474-0 | ||
135887940 | 11230 | 0 | None | 93 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.9 | COc1ccccc1N1CCN(CCCNC2=Nc3ccccc3OC2)CC1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1179506 | 11230 | 0 | None | 93 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.9 | COc1ccccc1N1CCN(CCCNC2=Nc3ccccc3OC2)CC1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL80711 | 11230 | 0 | None | 93 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.9 | COc1ccccc1N1CCN(CCCNC2=Nc3ccccc3OC2)CC1 | 10.1016/S0960-894X(97)00442-3 | ||
44264642 | 203095 | 0 | None | 75 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7506 | 203095 | 0 | None | 75 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1 | 10.1016/s0960-894x(98)00692-1 | ||
10454684 | 203097 | 0 | None | 467 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 418 | 3 | 0 | 4 | 3.3 | Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7508 | 203097 | 0 | None | 467 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 418 | 3 | 0 | 4 | 3.3 | Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(98)00692-1 | ||
9909648 | 203861 | 1 | None | -1 | 12 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 340 | 4 | 0 | 3 | 3.7 | Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
CHEMBL81330 | 203861 | 1 | None | -1 | 12 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 340 | 4 | 0 | 3 | 3.7 | Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/jm960084f | ||
9995379 | 106467 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 2.5 | O=C1Cc2c(cccc2N2CCN(Cc3ccccc3)CC2)N1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL314952 | 106467 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 2.5 | O=C1Cc2c(cccc2N2CCN(Cc3ccccc3)CC2)N1 | 10.1007/s00044-012-0055-5 | ||
10836365 | 205532 | 0 | None | 5 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 7 | 2 | 4 | 3.9 | COc1cc(NC(=O)C(C)C)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL93021 | 205532 | 0 | None | 5 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 7 | 2 | 4 | 3.9 | COc1cc(NC(=O)C(C)C)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
231915 | 91726 | 7 | None | 14 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 296 | 5 | 0 | 3 | 3.4 | CCOc1ccccc1N1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420892 | 91726 | 7 | None | 14 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 296 | 5 | 0 | 3 | 3.4 | CCOc1ccccc1N1CCN(Cc2ccccc2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
10220333 | 4143 | 0 | None | 36 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 236 | 0 | 0 | 4 | 3.4 | Cc1sc(C)c2c1SCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL100203 | 4143 | 0 | None | 36 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 236 | 0 | 0 | 4 | 3.4 | Cc1sc(C)c2c1SCc1cnn(C)c1-2 | 10.1016/s0960-894x(03)00587-0 | ||
44336030 | 5140 | 0 | None | 251 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 3 | 3.3 | CCc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL106169 | 5140 | 0 | None | 251 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 3 | 3.3 | CCc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
10001810 | 5269 | 0 | None | 91 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 413 | 5 | 0 | 4 | 3.4 | COc1cc(Cl)ccc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL106862 | 5269 | 0 | None | 91 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 413 | 5 | 0 | 4 | 3.4 | COc1cc(Cl)ccc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335919 | 108441 | 0 | None | 31 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 3 | 3.5 | CC[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL321121 | 108441 | 0 | None | 31 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 3 | 3.5 | CC[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
1946142 | 109133 | 2 | None | 478 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 393 | 4 | 0 | 5 | 2.5 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc3c(c2)OCO3)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL322222 | 109133 | 2 | None | 478 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 393 | 4 | 0 | 5 | 2.5 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc3c(c2)OCO3)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335739 | 4778 | 0 | None | 7 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 4 | 0 | 2 | 4.7 | Cc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1F | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104273 | 4778 | 0 | None | 7 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 4 | 0 | 2 | 4.7 | Cc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1F | 10.1016/s0960-894x(02)00655-8 | ||
9799123 | 5543 | 0 | None | 35 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107742 | 5543 | 0 | None | 35 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
44336006 | 6174 | 0 | None | 398 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 387 | 5 | 0 | 5 | 3.5 | O=c1sc2ccccc2n1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL108157 | 6174 | 0 | None | 398 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 387 | 5 | 0 | 5 | 3.5 | O=c1sc2ccccc2n1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
54581963 | 61272 | 0 | None | -11 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 437 | 8 | 0 | 5 | 3.7 | COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771105 | 61272 | 0 | None | -11 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 437 | 8 | 0 | 5 | 3.7 | COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O | 10.1016/j.bmcl.2010.12.083 | ||
11559589 | 122192 | 0 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL360424 | 122192 | 0 | None | -1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@H]1CCN(Cc2ccccc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
135921193 | 39954 | 0 | None | 93 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1ccccc1N1CCN(CCNC2=Nc3ccccc3OC2)CC1 | 10.1021/jm981041x | ||
CHEMBL148024 | 39954 | 0 | None | 93 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1ccccc1N1CCN(CCNC2=Nc3ccccc3OC2)CC1 | 10.1021/jm981041x | ||
9909648 | 203861 | 1 | None | 1 | 12 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 340 | 4 | 0 | 3 | 3.7 | Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL81330 | 203861 | 1 | None | 1 | 12 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 340 | 4 | 0 | 3 | 3.7 | Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
10684706 | 85295 | 0 | None | 75 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 287 | 9 | 2 | 4 | 2.8 | Oc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL22892 | 85295 | 0 | None | 75 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 287 | 9 | 2 | 4 | 2.8 | Oc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
10617366 | 203731 | 0 | None | 28 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 343 | 5 | 1 | 2 | 4.7 | Cc1c(-c2ccccc2)n[nH]c1C1=CCN(CCc2ccccc2)CC1 | 10.1021/jm970111h | ||
CHEMBL80318 | 203731 | 0 | None | 28 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 343 | 5 | 1 | 2 | 4.7 | Cc1c(-c2ccccc2)n[nH]c1C1=CCN(CCc2ccccc2)CC1 | 10.1021/jm970111h | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(02)00316-5 | ||
10980338 | 167445 | 0 | None | 1584 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1 | 10.1021/jm015522j | ||
CHEMBL432059 | 167445 | 0 | None | 1584 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1 | 10.1021/jm015522j | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1016/j.bmcl.2013.07.033 | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1016/j.bmcl.2013.07.033 | ||
10684706 | 85295 | 0 | None | 75 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 287 | 9 | 2 | 4 | 2.8 | Oc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL22892 | 85295 | 0 | None | 75 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 287 | 9 | 2 | 4 | 2.8 | Oc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
11003833 | 44510 | 0 | None | -1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 397 | 9 | 1 | 5 | 3.0 | COc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL152159 | 44510 | 0 | None | -1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 397 | 9 | 1 | 5 | 3.0 | COc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
10404144 | 203591 | 19 | None | -1 | 10 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL7927 | 203591 | 19 | None | -1 | 10 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
21219164 | 91119 | 0 | None | 120 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 5.3 | Cc1c(-c2ccccc2)cnn1C1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL24051 | 91119 | 0 | None | 120 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 5.3 | Cc1c(-c2ccccc2)cnn1C1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
12052258 | 99632 | 0 | None | 4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 5.3 | Cc1nn(C2CCN(Cc3cccc(Cl)c3)CC2)cc1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL287412 | 99632 | 0 | None | 4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 365 | 4 | 0 | 3 | 5.3 | Cc1nn(C2CCN(Cc3cccc(Cl)c3)CC2)cc1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
9840672 | 204594 | 0 | None | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 6 | 2 | 3 | 3.8 | FC(F)(F)c1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL87192 | 204594 | 0 | None | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 335 | 6 | 2 | 3 | 3.8 | FC(F)(F)c1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
2780 | 110040 | 32 | None | -4 | 11 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL325109 | 110040 | 32 | None | -4 | 11 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(03)00678-4 | ||
44412458 | 138764 | 3 | None | 28 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 316 | 4 | 0 | 4 | 3.6 | C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL379177 | 138764 | 3 | None | 28 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 316 | 4 | 0 | 4 | 3.6 | C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1 | 10.1016/j.bmcl.2006.02.075 | ||
9821010 | 55167 | 0 | None | 575 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 4 | 0 | 4 | 3.9 | Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ccc(Cl)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL161982 | 55167 | 0 | None | 575 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 4 | 0 | 4 | 3.9 | Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ccc(Cl)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
44419066 | 83944 | 0 | None | 28 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.6 | c1ccc(C2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL221814 | 83944 | 0 | None | 28 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.6 | c1ccc(C2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1 | 10.1021/jm0611152 | ||
44340227 | 110152 | 0 | None | 16 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 486 | 5 | 1 | 3 | 4.5 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL325772 | 110152 | 0 | None | 16 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 486 | 5 | 1 | 3 | 4.5 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10574818 | 206164 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 433 | 7 | 2 | 4 | 4.1 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCCCC2)C1 | 10.1021/jm9601720 | ||
CHEMBL96703 | 206164 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 433 | 7 | 2 | 4 | 4.1 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCCCC2)C1 | 10.1021/jm9601720 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
9948461 | 19301 | 1 | None | 5 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 269 | 9 | 1 | 2 | 3.7 | c1ccc(CCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL129931 | 19301 | 1 | None | 5 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 269 | 9 | 1 | 2 | 3.7 | c1ccc(CCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
155532505 | 171192 | 0 | None | 9 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 5 | 5.0 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2F)c2ccc(Br)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4467437 | 171192 | 0 | None | 9 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 5 | 5.0 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2F)c2ccc(Br)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
127028185 | 138806 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 5 | 1 | 4 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(Cl)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792751 | 138806 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 5 | 1 | 4 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4cccc(Cl)n4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
54580906 | 61276 | 0 | None | -15 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 459 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771109 | 61276 | 0 | None | -15 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 459 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
53363109 | 63517 | 0 | None | 19 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 465 | 11 | 0 | 8 | 4.0 | CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803030 | 63517 | 0 | None | 19 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 465 | 11 | 0 | 8 | 4.0 | CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(98)00108-5 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(98)00108-5 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(98)00108-5 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(98)00108-5 | ||
22065997 | 98896 | 0 | None | 64 | 4 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL282424 | 98896 | 0 | None | 64 | 4 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/s0960-894x(01)00241-4 | ||
44400500 | 165507 | 0 | None | -1 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
CHEMBL425731 | 165507 | 0 | None | -1 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050170s | ||||
10593191 | 188519 | 0 | None | 33 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL51023 | 188519 | 0 | None | 33 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
44394667 | 66704 | 0 | None | 27 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2ccsc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL187113 | 66704 | 0 | None | 27 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.4 | O=C(N[C@@H]1CCN(Cc2ccccc2)C1)c1cccc(-c2ccsc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
10741841 | 205351 | 0 | None | 9 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(CCc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL91859 | 205351 | 0 | None | 9 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(CCc2ccccc2)C1 | 10.1021/jm9601720 | ||
155513773 | 169257 | 0 | None | 12 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 551 | 10 | 2 | 5 | 4.9 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(Br)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4439644 | 169257 | 0 | None | 12 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 551 | 10 | 2 | 5 | 4.9 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccc(Br)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
54580905 | 61274 | 0 | None | -13 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 469 | 8 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771107 | 61274 | 0 | None | -13 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 469 | 8 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
53327908 | 61280 | 0 | None | -28 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 470 | 8 | 0 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771112 | 61280 | 0 | None | -28 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 470 | 8 | 0 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
10594054 | 31198 | 1 | None | 97 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1 | 10.1021/jm0009989 | ||
CHEMBL140258 | 31198 | 1 | None | 97 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 350 | 3 | 1 | 3 | 4.0 | N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1 | 10.1021/jm0009989 | ||
45268292 | 195012 | 0 | None | 138 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 460 | 4 | 1 | 6 | 3.5 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL564688 | 195012 | 0 | None | 138 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 460 | 4 | 1 | 6 | 3.5 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
977 | 1155 | 3 | None | -10 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(cc1)OC[C@@H]1CC[C@@H]2N(C1)CCN(C2)c1ncc(cn1)F | 10.1016/s0960-894x(98)00108-5 | ||
9820261 | 1155 | 3 | None | -10 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(cc1)OC[C@@H]1CC[C@@H]2N(C1)CCN(C2)c1ncc(cn1)F | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL66227 | 1155 | 3 | None | -10 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(cc1)OC[C@@H]1CC[C@@H]2N(C1)CCN(C2)c1ncc(cn1)F | 10.1016/s0960-894x(98)00108-5 | ||
10473658 | 186610 | 3 | None | 38 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL49231 | 186610 | 3 | None | 38 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
133008 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm970111h | ||
3302 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm970111h | ||
CHEMBL444309 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm970111h | ||
133008 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm991029k | ||
3302 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm991029k | ||
CHEMBL444309 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm991029k | ||
1524 | 2150 | 89 | None | -3 | 51 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm0002432 | ||
197 | 2150 | 89 | None | -3 | 51 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm0002432 | ||
3822 | 2150 | 89 | None | -3 | 51 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm0002432 | ||
88 | 2150 | 89 | None | -3 | 51 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm0002432 | ||
CHEMBL51 | 2150 | 89 | None | -3 | 51 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm0002432 | ||
DB12465 | 2150 | 89 | None | -3 | 51 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm0002432 | ||
133008 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm0002432 | ||
3302 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm0002432 | ||
CHEMBL444309 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm0002432 | ||
44209480 | 69827 | 0 | None | -3 | 11 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL1940418 | 69827 | 0 | None | -3 | 11 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
44209480 | 69827 | 0 | None | -3 | 11 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL1940418 | 69827 | 0 | None | -3 | 11 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
44209480 | 69827 | 0 | None | -3 | 11 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940418 | 69827 | 0 | None | -3 | 11 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
44209480 | 69827 | 0 | None | -3 | 11 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940418 | 69827 | 0 | None | -3 | 11 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
133008 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm960072u | ||
3302 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm960072u | ||
CHEMBL444309 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm960072u | ||
15817410 | 57231 | 0 | None | 331 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL166269 | 57231 | 0 | None | 331 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
168275783 | 192225 | 0 | None | 354 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc([N+](=O)[O-])c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5176100 | 192225 | 0 | None | 354 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc([N+](=O)[O-])c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221583 | 192225 | 0 | None | 354 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2cccc([N+](=O)[O-])c2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
9995264 | 205454 | 0 | None | 93 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 305 | 2 | 0 | 3 | 3.7 | Cc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
CHEMBL92489 | 205454 | 0 | None | 93 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 305 | 2 | 0 | 3 | 3.7 | Cc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 | 10.1021/jm970170v | ||
10691599 | 200902 | 0 | None | 22 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)no3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL61195 | 200902 | 0 | None | 22 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)no3)CC2)cc1 | 10.1021/jm970111h | ||
44278788 | 109849 | 1 | None | 147 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 327 | 7 | 1 | 4 | 3.0 | OC(COc1ccccc1)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL32402 | 109849 | 1 | None | 147 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 327 | 7 | 1 | 4 | 3.0 | OC(COc1ccccc1)CN1CCC(Oc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm015522j | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm015522j | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm049612a | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm049612a | ||
9906978 | 42466 | 1 | None | 1 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL150161 | 42466 | 1 | None | 1 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
9906978 | 42466 | 1 | None | 1 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
CHEMBL150161 | 42466 | 1 | None | 1 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
973 | 1154 | 33 | None | -9 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
9796720 | 1154 | 33 | None | -9 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
CHEMBL77395 | 1154 | 33 | None | -9 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 10.1021/jm030505a | ||
188942 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm0002432 | ||
3297 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm0002432 | ||
979 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm0002432 | ||
CHEMBL103772 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm0002432 | ||
155515931 | 169444 | 0 | None | 17 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 509 | 10 | 2 | 5 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2F)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4442470 | 169444 | 0 | None | 17 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 509 | 10 | 2 | 5 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2F)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00218-7 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00218-7 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00218-7 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00218-7 | ||
10691599 | 200902 | 0 | None | 22 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)no3)CC2)cc1 | 10.1021/jm960072u | ||
CHEMBL61195 | 200902 | 0 | None | 22 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)no3)CC2)cc1 | 10.1021/jm960072u | ||
10567430 | 118788 | 1 | None | 851 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1 | 10.1021/jm0009989 | ||
CHEMBL343880 | 118788 | 1 | None | 851 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1 | 10.1021/jm0009989 | ||
10404144 | 203591 | 19 | None | 1 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL7927 | 203591 | 19 | None | 1 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1 | 10.1021/jm060166w | ||
9905249 | 99440 | 0 | None | -2 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL28607 | 99440 | 0 | None | -2 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
133079 | 3581 | 33 | None | 1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
980 | 3581 | 33 | None | 1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL69759 | 3581 | 33 | None | 1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/acs.jmedchem.7b00151 | ||
44454734 | 97278 | 0 | None | 20 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 344 | 7 | 0 | 4 | 3.4 | COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1 | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL271513 | 97278 | 0 | None | 20 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 344 | 7 | 0 | 4 | 3.4 | COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1 | 10.1016/j.bmcl.2007.12.026 | ||
3303 | 2213 | 41 | None | -1 | 15 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00241-4 | ||
5311200 | 2213 | 41 | None | -1 | 15 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL267014 | 2213 | 41 | None | -1 | 15 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10.1016/s0960-894x(01)00241-4 | ||
10545941 | 38689 | 0 | None | 181 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 4 | 1 | 4 | 3.4 | COc1ccc(C2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL146757 | 38689 | 0 | None | 181 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 4 | 1 | 4 | 3.4 | COc1ccc(C2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
188942 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm960637m | ||
3297 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm960637m | ||
979 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm960637m | ||
CHEMBL103772 | 2778 | 38 | None | -12 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 10.1021/jm960637m | ||
44326212 | 205695 | 0 | None | -1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 459 | 6 | 2 | 4 | 4.5 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2C3CCCC2CCC3)C1 | 10.1021/jm9601720 | ||
CHEMBL94050 | 205695 | 0 | None | -1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 459 | 6 | 2 | 4 | 4.5 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2C3CCCC2CCC3)C1 | 10.1021/jm9601720 | ||
155512259 | 169081 | 0 | None | 15 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 509 | 10 | 2 | 5 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2cccc(F)c2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4437233 | 169081 | 0 | None | 15 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 509 | 10 | 2 | 5 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2cccc(F)c2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
132060812 | 161487 | 0 | None | 16 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 329 | 4 | 0 | 2 | 4.9 | COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1 | 10.1016/j.ejmech.2018.02.024 | ||
CHEMBL4160064 | 161487 | 0 | None | 16 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 329 | 4 | 0 | 2 | 4.9 | COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1 | 10.1016/j.ejmech.2018.02.024 | ||
71450707 | 83664 | 0 | None | 15 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 3.9 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207640 | 83664 | 0 | None | 15 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 3.9 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
45273443 | 193958 | 0 | None | 66 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 392 | 4 | 1 | 6 | 2.2 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL556288 | 193958 | 0 | None | 66 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 392 | 4 | 1 | 6 | 2.2 | Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O | 10.1016/j.bmc.2009.05.015 | ||
21997225 | 55494 | 0 | None | 48 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OCC2CCC3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL162265 | 55494 | 0 | None | 48 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OCC2CCC3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
11738728 | 18313 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(C)c(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm030505a | ||
CHEMBL127290 | 18313 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(C)c(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm030505a | ||
9817774 | 111009 | 0 | None | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 299 | 6 | 3 | 4 | 3.0 | Sc1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL327782 | 111009 | 0 | None | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 299 | 6 | 3 | 4 | 3.0 | Sc1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00194-7 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00194-7 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00194-7 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/S0960-894X(97)00194-7 | ||
10760638 | 187593 | 0 | None | 131 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL49876 | 187593 | 0 | None | 131 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
56852956 | 111551 | 1 | None | 10 | 9 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289656 | 111551 | 1 | None | 10 | 9 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
10425969 | 100539 | 3 | None | 346 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 317 | 4 | 1 | 4 | 2.8 | N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL294459 | 100539 | 3 | None | 346 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 317 | 4 | 1 | 4 | 2.8 | N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
792460 | 91714 | 7 | None | 28 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 302 | 5 | 0 | 4 | 3.5 | CCOc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420773 | 91714 | 7 | None | 28 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 302 | 5 | 0 | 4 | 3.5 | CCOc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
56852956 | 111551 | 1 | None | 10 | 9 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289656 | 111551 | 1 | None | 10 | 9 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
137634397 | 155564 | 0 | None | -8 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 8 | 3 | 10 | 2.2 | O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4063145 | 155564 | 0 | None | -8 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 8 | 3 | 10 | 2.2 | O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1 | 10.1016/j.bmc.2017.08.037 | ||
10069973 | 52120 | 0 | None | -4 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 407 | 9 | 0 | 6 | 4.4 | COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 | 10.1021/jm020994z | ||
CHEMBL159022 | 52120 | 0 | None | -4 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 407 | 9 | 0 | 6 | 4.4 | COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1 | 10.1021/jm020994z | ||
44369020 | 118954 | 0 | None | 2 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 374 | 6 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL345111 | 118954 | 0 | None | 2 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 374 | 6 | 1 | 5 | 2.3 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/jm020952a | ||
10425450 | 199 | 23 | None | -1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
3301 | 199 | 23 | None | -1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL375596 | 199 | 23 | None | -1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
17461770 | 200155 | 1 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 3.9 | COc1cc2ccccc2cc1C(=O)NC1CCN(Cc2ccccc2)C1 | 10.1021/jm960017l | ||
CHEMBL60708 | 200155 | 1 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 3.9 | COc1cc2ccccc2cc1C(=O)NC1CCN(Cc2ccccc2)C1 | 10.1021/jm960017l | ||
44370032 | 47125 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 5 | 1 | 2 | 4.4 | C1=C(/C=C/c2ccccc2)CCN(CCc2cc3ccc[nH]c-3n2)C1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL154482 | 47125 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 5 | 1 | 2 | 4.4 | C1=C(/C=C/c2ccccc2)CCN(CCc2cc3ccc[nH]c-3n2)C1 | 10.1016/s0960-894x(99)00025-6 | ||
10092819 | 16594 | 0 | None | -28 | 12 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm049612a | ||
CHEMBL124444 | 16594 | 0 | None | -28 | 12 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm049612a | ||
10092819 | 16594 | 0 | None | -28 | 12 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm025558r | ||
CHEMBL124444 | 16594 | 0 | None | -28 | 12 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm025558r | ||
11068912 | 30648 | 0 | None | 8 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
CHEMBL139722 | 30648 | 0 | None | 8 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
10542345 | 18692 | 0 | None | 7 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 9 | 1 | 3 | 4.1 | Cc1ccc(SCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL128281 | 18692 | 0 | None | 7 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 9 | 1 | 3 | 4.1 | Cc1ccc(SCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020952a | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020952a | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020952a | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020952a | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020952a | ||
10781960 | 15384 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 320 | 3 | 0 | 4 | 3.1 | O=c1ccc2cc(CN3CCN(c4ccccc4)CC3)ccc2o1 | 10.1021/jm990266k | ||
CHEMBL121993 | 15384 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 320 | 3 | 0 | 4 | 3.1 | O=c1ccc2cc(CN3CCN(c4ccccc4)CC3)ccc2o1 | 10.1021/jm990266k | ||
162671033 | 183173 | 0 | None | 3 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4793296 | 183173 | 0 | None | 3 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4803797 | 183173 | 0 | None | 3 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
154726793 | 175659 | 1 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4590966 | 175659 | 1 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4594692 | 175659 | 1 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020938y | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020938y | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020938y | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020938y | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm020938y | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
621 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
83 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
49782602 | 16987 | 0 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 583 | 6 | 1 | 3 | 7.4 | O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
CHEMBL1256169 | 16987 | 0 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 583 | 6 | 1 | 3 | 7.4 | O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
49782604 | 17341 | 0 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1257927 | 17341 | 0 | None | 1 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1 | 10.1021/jm100899z | ||
137636351 | 155332 | 0 | None | -87 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.0 | O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4060403 | 155332 | 0 | None | -87 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.0 | O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/acs.jmedchem.6b01857 | ||
73347474 | 90628 | 0 | None | -30 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 18 | 1 | 7 | 5.4 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397478 | 90628 | 0 | None | -30 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 18 | 1 | 7 | 5.4 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1 | 10.1021/jm400520c | ||
71733935 | 90552 | 0 | None | -43 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm501889t | ||
CHEMBL2396663 | 90552 | 0 | None | -43 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm501889t | ||
122177641 | 120696 | 0 | None | -47 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | ||
CHEMBL3577342 | 120696 | 0 | None | -47 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | ||
11474021 | 4726 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1ccc(F)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104089 | 4726 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 365 | 6 | 0 | 4 | 3.8 | COc1ccc(F)cc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991138z | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991138z | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991138z | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991138z | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991138z | ||
53248675 | 66037 | 0 | None | -213 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813594 | 66037 | 0 | None | -213 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851639 | 66037 | 0 | None | -213 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
168293632 | 192398 | 0 | None | 27 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 320 | 5 | 1 | 3 | 3.3 | c1ccc(N2CCN(CCCc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5203856 | 192398 | 0 | None | 27 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 320 | 5 | 1 | 3 | 3.3 | c1ccc(N2CCN(CCCc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222695 | 192398 | 0 | None | 27 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 320 | 5 | 1 | 3 | 3.3 | c1ccc(N2CCN(CCCc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
10092819 | 16594 | 0 | None | -28 | 12 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm0611152 | ||
CHEMBL124444 | 16594 | 0 | None | -28 | 12 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 407 | 8 | 1 | 5 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1021/jm0611152 | ||
11068912 | 30648 | 0 | None | 8 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
CHEMBL139722 | 30648 | 0 | None | 8 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 1 | 6 | 1.9 | COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2004.07.068 | ||
90644068 | 111545 | 0 | None | 1 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 369 | 6 | 0 | 4 | 4.6 | Clc1ccc(N2CCN(CCCCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289650 | 111545 | 0 | None | 1 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 369 | 6 | 0 | 4 | 4.6 | Clc1ccc(N2CCN(CCCCc3nc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
10616050 | 186064 | 3 | None | 81 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL48807 | 186064 | 3 | None | 81 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 325 | 5 | 1 | 4 | 2.2 | COc1ccccc1N1CCN(CNC(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
164621627 | 184901 | 0 | None | -13 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 369 | 5 | 0 | 4 | 3.7 | O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4862180 | 184901 | 0 | None | -13 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 369 | 5 | 0 | 4 | 3.7 | O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
44419053 | 83871 | 0 | None | -79 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.2 | C#Cc1ccc2sc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1021/jm0611152 | ||
CHEMBL221397 | 83871 | 0 | None | -79 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.2 | C#Cc1ccc2sc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2c1 | 10.1021/jm0611152 | ||
44323890 | 205190 | 0 | None | -4 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 316 | 1 | 0 | 2 | 4.2 | C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL90977 | 205190 | 0 | None | -4 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 316 | 1 | 0 | 2 | 4.2 | C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
49783039 | 17471 | 0 | None | -120 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 421 | 7 | 1 | 4 | 4.9 | Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1258383 | 17471 | 0 | None | -120 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 421 | 7 | 1 | 4 | 4.9 | Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1 | 10.1021/jm100899z | ||
127045855 | 139134 | 0 | None | -3 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 319 | 8 | 4 | 6 | 1.8 | COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3797876 | 139134 | 0 | None | -3 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 319 | 8 | 4 | 6 | 1.8 | COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1 | 10.1016/j.bmc.2016.04.028 | ||
118709163 | 112910 | 0 | None | -112 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 888 | 21 | 0 | 8 | 11.3 | O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318835 | 112910 | 0 | None | -112 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 888 | 21 | 0 | 8 | 11.3 | O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
137655795 | 158036 | 0 | None | -120 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 453 | 7 | 2 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4091933 | 158036 | 0 | None | -120 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 453 | 7 | 2 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
3038495 | 700 | 30 | None | -91 | 19 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm040190e | ||
7625 | 700 | 30 | None | -91 | 19 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm040190e | ||
CHEMBL25236 | 700 | 30 | None | -91 | 19 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm040190e | ||
10917920 | 110958 | 0 | None | -3801 | 10 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL327527 | 110958 | 0 | None | -3801 | 10 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
10404663 | 166308 | 8 | None | -100 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 9 | 1 | 3 | 3.0 | C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL428561 | 166308 | 8 | None | -100 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 9 | 1 | 3 | 3.0 | C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC | 10.1016/j.bmc.2007.07.017 | ||
122189390 | 122729 | 0 | None | -323 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 469 | 6 | 0 | 8 | 3.4 | O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613876 | 122729 | 0 | None | -323 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 469 | 6 | 0 | 8 | 3.4 | O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12 | 10.1016/j.bmc.2015.07.050 | ||
25129807 | 102819 | 0 | None | -154 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 366 | 3 | 2 | 2 | 4.8 | O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL3084502 | 102819 | 0 | None | -154 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 366 | 3 | 2 | 2 | 4.8 | O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12 | 10.1016/j.bmc.2008.12.054 | ||
44330640 | 206560 | 1 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 218 | 0 | 0 | 3 | 3.0 | Cc1sc(C)c2c1CCCc1nccn1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL99054 | 206560 | 1 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 218 | 0 | 0 | 3 | 3.0 | Cc1sc(C)c2c1CCCc1nccn1-2 | 10.1016/s0960-894x(03)00587-0 | ||
164619170 | 185019 | 0 | None | -45 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 396 | 9 | 2 | 4 | 3.8 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4863832 | 185019 | 0 | None | -45 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 396 | 9 | 2 | 4 | 3.8 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
11720119 | 82813 | 0 | None | -27 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 12 | 1 | 7 | 3.6 | CCCc1c(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
CHEMBL218607 | 82813 | 0 | None | -27 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 12 | 1 | 7 | 3.6 | CCCc1c(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccccc1 | 10.1021/jm0611152 | ||
164619170 | 185019 | 0 | None | -45 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 396 | 9 | 2 | 4 | 3.8 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4863832 | 185019 | 0 | None | -45 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 396 | 9 | 2 | 4 | 3.8 | COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
9888555 | 165052 | 11 | None | -208 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm900095y | ||
CHEMBL424294 | 165052 | 11 | None | -208 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm900095y | ||
130431334 | 173854 | 0 | None | -1513 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 454 | 8 | 3 | 4 | 3.7 | CCc1cccc(N2CCN(CCC(O)CNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4552939 | 173854 | 0 | None | -1513 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 454 | 8 | 3 | 4 | 3.7 | CCc1cccc(N2CCN(CCC(O)CNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
168271259 | 189921 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cc1nc(CN2CCC(OCc3cccc(C(F)(F)F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179459 | 189921 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cc1nc(CN2CCC(OCc3cccc(C(F)(F)F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
53248159 | 61660 | 0 | None | -501 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 500 | 8 | 1 | 4 | 5.3 | O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1 | 10.1021/jm200288r | ||
CHEMBL1774384 | 61660 | 0 | None | -501 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 500 | 8 | 1 | 4 | 5.3 | O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1 | 10.1021/jm200288r | ||
10098342 | 137463 | 0 | None | -891 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 5.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(Br)ccc2o1 | 10.1021/jm0611152 | ||
CHEMBL376445 | 137463 | 0 | None | -891 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 5.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(Br)ccc2o1 | 10.1021/jm0611152 | ||
72164300 | 91723 | 0 | None | 2 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 370 | 3 | 0 | 2 | 5.5 | Clc1cccc(N2CCN(Cc3cccc4ccccc34)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420782 | 91723 | 0 | None | 2 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 370 | 3 | 0 | 2 | 5.5 | Clc1cccc(N2CCN(Cc3cccc4ccccc34)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
44393415 | 64899 | 0 | None | -12 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 499 | 8 | 1 | 5 | 3.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL182652 | 64899 | 0 | None | -12 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 499 | 8 | 1 | 5 | 3.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1 | 10.1016/j.bmcl.2004.05.052 | ||
44336352 | 110511 | 0 | None | 4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 425 | 6 | 0 | 3 | 4.6 | CCC1(CC)Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL326250 | 110511 | 0 | None | 4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 425 | 6 | 0 | 3 | 4.6 | CCC1(CC)Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
9818076 | 16048 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 308 | 7 | 2 | 4 | 3.4 | O=c1ccc2ccc(CNCCCNc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL122427 | 16048 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 308 | 7 | 2 | 4 | 3.4 | O=c1ccc2ccc(CNCCCNc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
164621627 | 184901 | 0 | None | -13 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 369 | 5 | 0 | 4 | 3.7 | O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4862180 | 184901 | 0 | None | -13 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 369 | 5 | 0 | 4 | 3.7 | O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
60167166 | 74945 | 0 | None | 1 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.7 | Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL2037430 | 74945 | 0 | None | 1 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.7 | Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
60167166 | 74945 | 0 | None | 1 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.7 | Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037430 | 74945 | 0 | None | 1 | 8 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.7 | Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
44431487 | 87646 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1ccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234646 | 87646 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.2 | COc1ccc(CN2CCC(NC(=O)c3ccc4ccccc4c3)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
137632761 | 156033 | 0 | None | -13 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 8 | 3 | 9 | 2.7 | O=c1ccc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2[nH]1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4068561 | 156033 | 0 | None | -13 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 8 | 3 | 9 | 2.7 | O=c1ccc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2[nH]1 | 10.1016/j.bmc.2017.08.037 | ||
137654675 | 158088 | 0 | None | -8 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 433 | 7 | 2 | 7 | 2.9 | O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4092441 | 158088 | 0 | None | -8 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 433 | 7 | 2 | 7 | 2.9 | O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 | 10.1021/acs.jmedchem.7b00363 | ||
137633705 | 156077 | 0 | None | -57 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 474 | 7 | 2 | 7 | 4.0 | O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4069091 | 156077 | 0 | None | -57 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 474 | 7 | 2 | 7 | 4.0 | O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1 | 10.1021/acs.jmedchem.6b01857 | ||
122181331 | 121358 | 0 | None | -15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 414 | 9 | 1 | 3 | 5.4 | CCCN(CCCCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590082 | 121358 | 0 | None | -15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 414 | 9 | 1 | 3 | 5.4 | CCCN(CCCCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
10691634 | 100184 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 387 | 7 | 0 | 3 | 5.7 | COc1cc2ccccc2cc1C(=O)CCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL292186 | 100184 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 387 | 7 | 0 | 3 | 5.7 | COc1cc2ccccc2cc1C(=O)CCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
11793892 | 196374 | 0 | None | 31 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 375 | 7 | 0 | 3 | 5.3 | COc1cc2ccccc2cc1COCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL57407 | 196374 | 0 | None | 31 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 375 | 7 | 0 | 3 | 5.3 | COc1cc2ccccc2cc1COCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
44273912 | 77696 | 0 | None | 50 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.8 | CCCCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20996 | 77696 | 0 | None | 50 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.8 | CCCCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
44273897 | 98255 | 0 | None | 50 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 395 | 6 | 1 | 3 | 3.5 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Br)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL277669 | 98255 | 0 | None | 50 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 395 | 6 | 1 | 3 | 3.5 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(Br)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
621 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
83 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2013.12.024 | ||
76325152 | 105890 | 0 | None | -3 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115579 | 105890 | 0 | None | -3 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139262 | 105890 | 0 | None | -3 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | ||
53248677 | 66086 | 0 | None | -446 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 439 | 10 | 1 | 5 | 3.9 | O=c1ccc2ccc(OCCCCN3CCN(c4ccccc4OCCF)CC3)cc2[nH]1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813595 | 66086 | 0 | None | -446 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 439 | 10 | 1 | 5 | 3.9 | O=c1ccc2ccc(OCCCCN3CCN(c4ccccc4OCCF)CC3)cc2[nH]1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851893 | 66086 | 0 | None | -446 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 439 | 10 | 1 | 5 | 3.9 | O=c1ccc2ccc(OCCCCN3CCN(c4ccccc4OCCF)CC3)cc2[nH]1 | 10.1016/j.bmc.2011.04.021 | ||
127053218 | 138948 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 334 | 5 | 0 | 4 | 3.5 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794336 | 138948 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 334 | 5 | 0 | 4 | 3.5 | c1ccc(OC[C@@H]2CN(Cc3ccc4ccccc4n3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
17469721 | 77671 | 6 | None | 9 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 320 | 4 | 0 | 6 | 2.0 | c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL209832 | 77671 | 6 | None | 9 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 320 | 4 | 0 | 6 | 2.0 | c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
10359539 | 58745 | 6 | None | 41 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL169459 | 58745 | 6 | None | 41 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.6 | c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
3033769 | 3229 | 54 | None | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10.1016/j.bmc.2007.07.017 | ||
3299 | 3229 | 54 | None | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10.1016/j.bmc.2007.07.017 | ||
94 | 3229 | 54 | None | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL8809 | 3229 | 54 | None | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10.1016/j.bmc.2007.07.017 | ||
DB12518 | 3229 | 54 | None | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10.1016/j.bmc.2007.07.017 | ||
25139180 | 183759 | 0 | None | -10 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 490 | 10 | 1 | 2 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1 | 10.1021/jm800895v | ||
CHEMBL484357 | 183759 | 0 | None | -10 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 490 | 10 | 1 | 2 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1 | 10.1021/jm800895v | ||
114840 | 69240 | 55 | None | 1 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 271 | 2 | 4 | 4 | 2.2 | Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL19344 | 69240 | 55 | None | 1 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 271 | 2 | 4 | 4 | 2.2 | Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL5079053 | 212829 | 0 | None | -107 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | CCc1cc(Cl)c(OC)c(C(=O)NCC2CCCN2CC(=O)N2CCC(c3ccccc3)(c3ccccc3)C2)c1O | 10.1021/acs.jmedchem.1c00611 | ||||
9926141 | 169689 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 294 | 6 | 2 | 4 | 3.0 | O=c1ccc2cc(CNCCNc3ccccc3)ccc2o1 | 10.1021/jm990266k | ||
CHEMBL444596 | 169689 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 294 | 6 | 2 | 4 | 3.0 | O=c1ccc2cc(CNCCNc3ccccc3)ccc2o1 | 10.1021/jm990266k | ||
11442138 | 68847 | 0 | None | -75 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | ||
CHEMBL192650 | 68847 | 0 | None | -75 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | ||
10470579 | 205642 | 0 | None | -16 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 309 | 4 | 3 | 4 | 2.8 | Oc1nc2c3c(ccc2[nH]1)CC[C@@H](CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL93753 | 205642 | 0 | None | -16 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 309 | 4 | 3 | 4 | 2.8 | Oc1nc2c3c(ccc2[nH]1)CC[C@@H](CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
155195487 | 172705 | 0 | None | -14 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CC1CC1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4525362 | 172705 | 0 | None | -14 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CC1CC1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
9816808 | 204587 | 0 | None | -51 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 267 | 6 | 2 | 3 | 2.7 | c1ccc(CNCCOc2cccc3[nH]ncc23)cc1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL87137 | 204587 | 0 | None | -51 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 267 | 6 | 2 | 3 | 2.7 | c1ccc(CNCCOc2cccc3[nH]ncc23)cc1 | 10.1016/s0960-894x(99)00434-5 | ||
49783419 | 17567 | 0 | None | -954 | 13 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
CHEMBL1258671 | 17567 | 0 | None | -954 | 13 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
130431277 | 169365 | 0 | None | -58 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 224 | 2 | 1 | 2 | 2.3 | CCc1cccc(N2CCNCC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4441358 | 169365 | 0 | None | -58 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 224 | 2 | 1 | 2 | 2.3 | CCc1cccc(N2CCNCC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
44376920 | 55068 | 0 | None | 3 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 381 | 5 | 1 | 6 | 2.4 | CC(=O)Nc1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL161899 | 55068 | 0 | None | 3 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 381 | 5 | 1 | 6 | 2.4 | CC(=O)Nc1ccc(OC[C@@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
44273925 | 76941 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 347 | 7 | 1 | 4 | 2.8 | COc1ccc(N2CCN(CCCCNC(=O)C(C)(C)C)CC2)cc1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20819 | 76941 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 347 | 7 | 1 | 4 | 2.8 | COc1ccc(N2CCN(CCCCNC(=O)C(C)(C)C)CC2)cc1 | 10.1016/0960-894X(96)00198-9 | ||
44273815 | 77781 | 2 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 317 | 6 | 1 | 3 | 2.8 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccccc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21035 | 77781 | 2 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 317 | 6 | 1 | 3 | 2.8 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccccc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
137636308 | 155661 | 0 | None | 8 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 329 | 7 | 0 | 3 | 2.8 | CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4064222 | 155661 | 0 | None | 8 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 329 | 7 | 0 | 3 | 2.8 | CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
10430685 | 54014 | 0 | None | -107 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 393 | 8 | 1 | 6 | 4.1 | O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O | 10.1021/jm020994z | ||
CHEMBL160817 | 54014 | 0 | None | -107 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 393 | 8 | 1 | 6 | 4.1 | O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O | 10.1021/jm020994z | ||
6466372 | 169495 | 12 | None | 93 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443054 | 169495 | 12 | None | 93 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
53248256 | 61706 | 0 | None | -316 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 473 | 8 | 1 | 4 | 4.5 | COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1 | 10.1021/jm200288r | ||
CHEMBL1774536 | 61706 | 0 | None | -316 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 473 | 8 | 1 | 4 | 4.5 | COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1 | 10.1021/jm200288r | ||
44438239 | 154395 | 1 | None | -13 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 4 | 2 | 3 | 4.4 | CSc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL401031 | 154395 | 1 | None | -13 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 4 | 2 | 3 | 4.4 | CSc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
168268918 | 189414 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 4.7 | Cc1cccc(CO[C@H]2CCCN(Cc3cc4ccc(Cl)cc4[nH]3)C2)n1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5171398 | 189414 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 4.7 | Cc1cccc(CO[C@H]2CCCN(Cc3cc4ccc(Cl)cc4[nH]3)C2)n1 | 10.1016/j.bmcl.2022.128615 | ||
15290395 | 99437 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 393 | 7 | 1 | 3 | 4.7 | OC(COc1cccc2ccccc12)CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL28605 | 99437 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 393 | 7 | 1 | 3 | 4.7 | OC(COc1cccc2ccccc12)CN1CCC(Cc2ccc(F)cc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
44278829 | 100011 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 393 | 7 | 1 | 4 | 4.8 | OC(COc1cccc2ccccc12)CN1CCC(Sc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL29087 | 100011 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 393 | 7 | 1 | 4 | 4.8 | OC(COc1cccc2ccccc12)CN1CCC(Sc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
10065188 | 101133 | 0 | None | 3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1021/jm970021c | ||
CHEMBL298763 | 101133 | 0 | None | 3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1021/jm970021c | ||
135398737 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
38 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
722 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
CHEMBL42 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
DB00363 | 944 | 89 | None | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
2865 | 4079 | 67 | None | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
59 | 4079 | 67 | None | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
60854 | 4079 | 67 | None | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL708 | 4079 | 67 | None | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
DB00246 | 4079 | 67 | None | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
9905720 | 167370 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1cccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)c1 | 10.1021/jm990266k | ||
CHEMBL431479 | 167370 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1cccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)c1 | 10.1021/jm990266k | ||
10704110 | 115241 | 0 | None | -42 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 219 | 3 | 1 | 2 | 2.6 | CCCN(C)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL335392 | 115241 | 0 | None | -42 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 219 | 3 | 1 | 2 | 2.6 | CCCN(C)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
16094699 | 81733 | 4 | None | 109 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.0 | Cc1cccc(C(=O)NCN2CCC(c3ccccn3)CC2)c1 | 10.1021/jm060662k | ||
CHEMBL216794 | 81733 | 4 | None | 109 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.0 | Cc1cccc(C(=O)NCN2CCC(c3ccccn3)CC2)c1 | 10.1021/jm060662k | ||
72544787 | 92698 | 0 | None | 6 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 587 | 12 | 3 | 12 | 1.2 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443008 | 92698 | 0 | None | 6 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 587 | 12 | 3 | 12 | 1.2 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
137644966 | 157948 | 0 | None | -45 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.1 | N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4091064 | 157948 | 0 | None | -45 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 456 | 6 | 1 | 6 | 4.1 | N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/acs.jmedchem.6b01857 | ||
21219160 | 91575 | 0 | None | 14 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.8 | c1ccc(CN2CCC(n3cc(-c4ccccc4)nn3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL24170 | 91575 | 0 | None | 14 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 4 | 0 | 4 | 3.8 | c1ccc(CN2CCC(n3cc(-c4ccccc4)nn3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
10014924 | 106787 | 0 | None | -16 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm0503805 | ||
CHEMBL316983 | 106787 | 0 | None | -16 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm0503805 | ||
10014924 | 106787 | 0 | None | -16 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm049269+ | ||
CHEMBL316983 | 106787 | 0 | None | -16 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 6 | 0 | 3 | 2.7 | CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1 | 10.1021/jm049269+ | ||
11383473 | 4811 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1ccccc1OCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104431 | 4811 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1ccccc1OCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1 | 10.1021/jm031111m | ||
11393899 | 4822 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104485 | 4822 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
11360382 | 4975 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 7 | 0 | 3 | 4.6 | CCCc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL105234 | 4975 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 7 | 0 | 3 | 4.6 | CCCc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
11795245 | 111212 | 0 | None | 25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.1 | COc1cccc2c1CCCC2NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm991138z | ||
CHEMBL2112375 | 111212 | 0 | None | 25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.1 | COc1cccc2c1CCCC2NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm991138z | ||
CHEMBL328681 | 111212 | 0 | None | 25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.1 | COc1cccc2c1CCCC2NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm991138z | ||
57394285 | 70115 | 0 | None | 5 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 378 | 6 | 0 | 3 | 5.2 | Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946125 | 70115 | 0 | None | 5 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 378 | 6 | 0 | 3 | 5.2 | Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
11151920 | 79624 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
CHEMBL212903 | 79624 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
76325152 | 105890 | 0 | None | -3 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115579 | 105890 | 0 | None | -3 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139262 | 105890 | 0 | None | -3 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | ||
109030343 | 170293 | 1 | None | 15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4454068 | 170293 | 1 | None | 15 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.5 | Cc1cccc(NC(=O)CCN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10065188 | 101133 | 0 | None | 3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL298763 | 101133 | 0 | None | 3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 4 | 1 | 3 | 2.9 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
49788940 | 18089 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.2 | N#Cc1ccc(N2CCN(CCNC(=O)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm100925m | ||
CHEMBL1270422 | 18089 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.2 | N#Cc1ccc(N2CCN(CCNC(=O)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm100925m | ||
10424961 | 205252 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | CC1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
CHEMBL544184 | 205252 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | CC1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
CHEMBL91350 | 205252 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | CC1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00004a016 | ||
10424961 | 205252 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | CC1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL544184 | 205252 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | CC1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL91350 | 205252 | 0 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | CC1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
44538690 | 109363 | 0 | None | -354 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 380 | 5 | 0 | 4 | 3.9 | O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCO3)c1ccc(F)cc1 | 10.1021/jm401958n | ||
CHEMBL3233432 | 109363 | 0 | None | -354 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 380 | 5 | 0 | 4 | 3.9 | O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCO3)c1ccc(F)cc1 | 10.1021/jm401958n | ||
72737750 | 114025 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 299 | 5 | 0 | 2 | 3.7 | Fc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335543 | 114025 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 299 | 5 | 0 | 2 | 3.7 | Fc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
137640152 | 156212 | 0 | None | -1995 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 631 | 15 | 3 | 10 | 4.0 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4070604 | 156212 | 0 | None | -1995 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 631 | 15 | 3 | 10 | 4.0 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1 | 10.1021/acs.jmedchem.7b00363 | ||
155514430 | 169297 | 0 | None | -14 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 310 | 6 | 0 | 3 | 3.8 | CCCCN1CCN(c2cc(CC)cc(Cl)c2OC)CC1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4440301 | 169297 | 0 | None | -14 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 310 | 6 | 0 | 3 | 3.8 | CCCCN1CCN(c2cc(CC)cc(Cl)c2OC)CC1 | 10.1021/acs.jmedchem.6b00860 | ||
168270455 | 189440 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 5 | 1 | 2 | 5.8 | Fc1cc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5171772 | 189440 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 5 | 1 | 2 | 5.8 | Fc1cc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
155195501 | 169526 | 0 | None | -28 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 410 | 7 | 2 | 6 | 3.2 | C[C@H]1COC(c2ccc(N)nc2)CN1CCCCOc1ccc2c(c1)NC(=O)CC2 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4443441 | 169526 | 0 | None | -28 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 410 | 7 | 2 | 6 | 3.2 | C[C@H]1COC(c2ccc(N)nc2)CN1CCCCOc1ccc2c(c1)NC(=O)CC2 | 10.1021/acs.jmedchem.9b00702 | ||
44355433 | 21979 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 383 | 8 | 0 | 3 | 5.9 | CCCN(CCc1cccs1)C1CCc2c(cccc2OC2CCCC2)C1 | 10.1021/jm960345l | ||
CHEMBL132261 | 21979 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 383 | 8 | 0 | 3 | 5.9 | CCCN(CCc1cccs1)C1CCc2c(cccc2OC2CCCC2)C1 | 10.1021/jm960345l | ||
10642702 | 38973 | 0 | None | -2 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 366 | 4 | 1 | 3 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
CHEMBL147003 | 38973 | 0 | None | -2 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 366 | 4 | 1 | 3 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
12997413 | 7049 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 5.5 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1Cc1ccccc1-2 | 10.1021/jm010146o | ||
CHEMBL108527 | 7049 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 5.5 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1Cc1ccccc1-2 | 10.1021/jm010146o | ||
44431494 | 148218 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 345 | 4 | 1 | 3 | 3.6 | O=C(NC1CCN(Cc2cccnc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL394042 | 148218 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 345 | 4 | 1 | 3 | 3.6 | O=C(NC1CCN(Cc2cccnc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
154725389 | 176074 | 1 | None | -3 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 11 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)C(C)C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4453405 | 176074 | 1 | None | -3 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 11 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)C(C)C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598003 | 176074 | 1 | None | -3 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 11 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)C(C)C | 10.1021/acs.jmedchem.9b01835 | ||
3198 | 203802 | 73 | None | -26 | 34 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL1201049 | 203802 | 73 | None | -26 | 34 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL808 | 203802 | 73 | None | -26 | 34 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
122180569 | 121207 | 0 | None | -208 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 8 | 0 | 6 | 5.0 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc4c(c3)Cc3ccccc3-4)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588914 | 121207 | 0 | None | -208 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 8 | 0 | 6 | 5.0 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc4c(c3)Cc3ccccc3-4)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
44431459 | 86894 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2ccccc2Cl)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL233214 | 86894 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2ccccc2Cl)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
53248361 | 61753 | 0 | None | -213 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 568 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 | 10.1021/jm1009956 | ||
CHEMBL1774991 | 61753 | 0 | None | -213 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 568 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 | 10.1021/jm1009956 | ||
10782049 | 19826 | 0 | None | 10 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 321 | 9 | 1 | 3 | 4.5 | Clc1ccc(SCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL130347 | 19826 | 0 | None | 10 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 321 | 9 | 1 | 3 | 4.5 | Clc1ccc(SCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
155515759 | 169438 | 0 | None | 3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 12 | 2 | 7 | 4.1 | COc1ccc(N(Cc2cccc(OC)c2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4442419 | 169438 | 0 | None | 3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 12 | 2 | 7 | 4.1 | COc1ccc(N(Cc2cccc(OC)c2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
109030515 | 175412 | 1 | None | 12 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4588808 | 175412 | 1 | None | 12 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
25070419 | 111286 | 0 | None | -9 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3cc4ccccn4n3)CC2)c1Cl | 10.1021/jm5004039 | ||
CHEMBL3287394 | 111286 | 0 | None | -9 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3cc4ccccn4n3)CC2)c1Cl | 10.1021/jm5004039 | ||
44405414 | 71476 | 0 | None | 1148 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 380 | 5 | 1 | 3 | 4.6 | O=C(N[C@H]1CCN(Cc2ccccc2F)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL196866 | 71476 | 0 | None | 1148 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 380 | 5 | 1 | 3 | 4.6 | O=C(N[C@H]1CCN(Cc2ccccc2F)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
11678172 | 77678 | 0 | None | -72 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 531 | 8 | 1 | 4 | 5.6 | COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm060138d | ||
CHEMBL209876 | 77678 | 0 | None | -72 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 531 | 8 | 1 | 4 | 5.6 | COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm060138d | ||
118709160 | 112907 | 0 | None | -2 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 846 | 18 | 0 | 8 | 10.1 | O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318832 | 112907 | 0 | None | -2 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 846 | 18 | 0 | 8 | 10.1 | O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
118709173 | 112922 | 0 | None | -19 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 944 | 20 | 0 | 10 | 9.4 | O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318846 | 112922 | 0 | None | -19 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 944 | 20 | 0 | 10 | 9.4 | O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
22727324 | 13317 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCCCc2cc(-c3ccc(F)cc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1192902 | 13317 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCCCc2cc(-c3ccc(F)cc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL544220 | 13317 | 0 | None | -1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCCCc2cc(-c3ccc(F)cc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
9975465 | 187068 | 0 | None | 109 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL49502 | 187068 | 0 | None | 109 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
10086123 | 110996 | 0 | None | -9 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 299 | 1 | 0 | 1 | 4.9 | C=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL327713 | 110996 | 0 | None | -9 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 299 | 1 | 0 | 1 | 4.9 | C=C1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
72205045 | 91514 | 0 | None | -1 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.3 | Clc1ccc(-n2cc(CCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL2414356 | 91514 | 0 | None | -1 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.3 | Clc1ccc(-n2cc(CCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
44436606 | 91565 | 0 | None | -102 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 505 | 7 | 1 | 3 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241641 | 91565 | 0 | None | -102 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 505 | 7 | 1 | 3 | 5.7 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
102262219 | 139529 | 0 | None | -6918 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 488 | 12 | 4 | 6 | 4.1 | COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3800400 | 139529 | 0 | None | -6918 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 488 | 12 | 4 | 6 | 4.1 | COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
15508238 | 4727 | 0 | None | 2 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 340 | 3 | 0 | 2 | 4.7 | C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL104092 | 4727 | 0 | None | 2 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 340 | 3 | 0 | 2 | 4.7 | C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1 | 10.1016/s0960-894x(99)00540-5 | ||
44319370 | 106564 | 0 | None | 1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 3.8 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL315564 | 106564 | 0 | None | 1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 3.8 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1 | 10.1016/s0960-894x(01)00484-x | ||
134156222 | 153817 | 0 | None | -50 | 8 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.2 | O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3986927 | 153817 | 0 | None | -50 | 8 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.2 | O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 | 10.1016/j.bmc.2016.09.019 | ||
44283889 | 119616 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 365 | 5 | 0 | 4 | 3.0 | COc1ccc(N2CCN(CCC3c4ccccc4C(=O)N3C)CC2)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL35114 | 119616 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 365 | 5 | 0 | 4 | 3.0 | COc1ccc(N2CCN(CCC3c4ccccc4C(=O)N3C)CC2)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
134156222 | 153817 | 0 | None | -50 | 8 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.2 | O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3986927 | 153817 | 0 | None | -50 | 8 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.2 | O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1 | 10.1016/j.bmc.2016.09.019 | ||
130431337 | 173515 | 0 | None | -2344 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 438 | 8 | 2 | 3 | 4.7 | CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4544583 | 173515 | 0 | None | -2344 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 438 | 8 | 2 | 3 | 4.7 | CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
44336052 | 5362 | 0 | None | 19 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | C[C@H]1CN(Cc2ccc(Cl)cc2)[C@H](C)CN1CC(=O)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107351 | 5362 | 0 | None | 19 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | C[C@H]1CN(Cc2ccc(Cl)cc2)[C@H](C)CN1CC(=O)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
10801405 | 26202 | 1 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)[C@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
CHEMBL135944 | 26202 | 1 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)[C@H]1CCc2ccc(OC)cc2C1 | 10.1021/jm960345l | ||
44393403 | 64747 | 0 | None | -125 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 533 | 8 | 1 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1 | 10.1021/jm900095y | ||
CHEMBL182379 | 64747 | 0 | None | -125 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 533 | 8 | 1 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1 | 10.1021/jm900095y | ||
53248213 | 61705 | 0 | None | -851 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.8 | O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm200288r | ||
CHEMBL1774535 | 61705 | 0 | None | -851 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.8 | O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm200288r | ||
164627741 | 185923 | 0 | None | -128 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 427 | 6 | 2 | 5 | 3.8 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4877460 | 185923 | 0 | None | -128 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 427 | 6 | 2 | 5 | 3.8 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
71062708 | 153772 | 0 | None | -19 | 12 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 368 | 7 | 0 | 5 | 2.8 | COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL3986651 | 153772 | 0 | None | -19 | 12 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 368 | 7 | 0 | 5 | 2.8 | COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
168294968 | 191821 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3cn4ccccc4n3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5208124 | 191821 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(COC2CCN(Cc3cn4ccccc4n3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm0611152 | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm0611152 | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm0611152 | ||
25895957 | 4775 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 414 | 5 | 0 | 5 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2cc([N+](=O)[O-])ccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104251 | 4775 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 414 | 5 | 0 | 5 | 3.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2cc([N+](=O)[O-])ccc21 | 10.1016/s0960-894x(02)00655-8 | ||
10641954 | 205204 | 0 | None | 77 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 355 | 3 | 0 | 4 | 4.0 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1Cl)CC3 | 10.1021/jm970170v | ||
CHEMBL91067 | 205204 | 0 | None | 77 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 355 | 3 | 0 | 4 | 4.0 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1Cl)CC3 | 10.1021/jm970170v | ||
10335148 | 78476 | 0 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 303 | 4 | 1 | 2 | 3.9 | C1=C(c2ccccc2)CCN(CCc2c[nH]c3ncccc23)C1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL2112912 | 78476 | 0 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 303 | 4 | 1 | 2 | 3.9 | C1=C(c2ccccc2)CCN(CCc2c[nH]c3ncccc23)C1 | 10.1016/s0960-894x(99)00025-6 | ||
21465540 | 110927 | 1 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 337 | 4 | 2 | 3 | 2.8 | O=C(NC(=O)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL327310 | 110927 | 1 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 337 | 4 | 2 | 3 | 2.8 | O=C(NC(=O)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
2946349 | 99272 | 6 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 325 | 7 | 1 | 3 | 3.4 | OC(COc1ccccc1)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL284892 | 99272 | 6 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 325 | 7 | 1 | 3 | 3.4 | OC(COc1ccccc1)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
9975465 | 187068 | 0 | None | 109 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
CHEMBL49502 | 187068 | 0 | None | 109 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1021/jm970021c | ||
44403210 | 70199 | 0 | None | -7 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 8 | 1 | 4 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL194727 | 70199 | 0 | None | -7 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 8 | 1 | 4 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
10137748 | 52781 | 0 | None | 28 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 433 | 4 | 0 | 4 | 3.8 | COc1cc(C)ccc1CN1CCN(C2CCc3cccc4c3N(C2=O)C(C)(C)C4)CC1 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL159742 | 52781 | 0 | None | 28 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 433 | 4 | 0 | 4 | 3.8 | COc1cc(C)ccc1CN1CCN(C2CCc3cccc4c3N(C2=O)C(C)(C)C4)CC1 | 10.1016/s0960-894x(02)01056-9 | ||
71652196 | 87026 | 0 | None | 15 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 368 | 4 | 1 | 5 | 3.6 | Oc1ccc(N2CCN(Cc3cnn(-c4ccc(Cl)cc4)c3)CC2)cc1 | 10.1016/j.ejmech.2012.08.011 | ||
CHEMBL2333732 | 87026 | 0 | None | 15 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 368 | 4 | 1 | 5 | 3.6 | Oc1ccc(N2CCN(Cc3cnn(-c4ccc(Cl)cc4)c3)CC2)cc1 | 10.1016/j.ejmech.2012.08.011 | ||
191 | 399 | 92 | None | -8 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1021/jm2013419 | ||
201 | 399 | 92 | None | -8 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1021/jm2013419 | ||
2170 | 399 | 92 | None | -8 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1021/jm2013419 | ||
CHEMBL1113 | 399 | 92 | None | -8 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1021/jm2013419 | ||
DB00543 | 399 | 92 | None | -8 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1021/jm2013419 | ||
44431481 | 87607 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2ccc(Br)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234472 | 87607 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2ccc(Br)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
137643951 | 157714 | 0 | None | -23 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 421 | 8 | 1 | 7 | 2.7 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4088639 | 157714 | 0 | None | -23 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 421 | 8 | 1 | 7 | 2.7 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
16105549 | 67443 | 0 | None | -75 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 462 | 9 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1 | 10.1021/jm0611152 | ||
CHEMBL1908879 | 67443 | 0 | None | -75 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 462 | 9 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1 | 10.1021/jm0611152 | ||
CHEMBL221640 | 67443 | 0 | None | -75 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 462 | 9 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1 | 10.1021/jm0611152 | ||
122181330 | 121357 | 0 | None | -39 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 396 | 9 | 1 | 3 | 5.3 | CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590081 | 121357 | 0 | None | -39 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 396 | 9 | 1 | 3 | 5.3 | CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
56833378 | 67991 | 0 | None | -18 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1121 | 39 | 2 | 14 | 10.7 | CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1 | 10.1021/jm2009919 | ||
CHEMBL1916549 | 67991 | 0 | None | -18 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1121 | 39 | 2 | 14 | 10.7 | CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1 | 10.1021/jm2009919 | ||
44276050 | 13169 | 0 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 405 | 9 | 0 | 5 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191675 | 13169 | 0 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 405 | 9 | 0 | 5 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL542809 | 13169 | 0 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 405 | 9 | 0 | 5 | 4.9 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
22727331 | 13216 | 0 | None | -5 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4OC)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1192096 | 13216 | 0 | None | -5 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4OC)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL543278 | 13216 | 0 | None | -5 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 451 | 10 | 0 | 7 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4OC)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
44438228 | 93123 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 1 | 2 | 5.0 | COC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246438 | 93123 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 1 | 2 | 5.0 | COC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
19958494 | 98994 | 0 | None | 9 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 360 | 3 | 1 | 3 | 3.9 | FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL283036 | 98994 | 0 | None | 9 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 360 | 3 | 1 | 3 | 3.9 | FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
127052467 | 140320 | 0 | None | 1 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819494 | 140320 | 0 | None | 1 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm049612a | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm049612a | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm049612a | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm025558r | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm025558r | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm025558r | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1016/j.bmcl.2005.07.037 | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1016/j.bmcl.2004.05.052 | ||
44381117 | 57526 | 0 | None | 25 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 415 | 7 | 2 | 4 | 3.6 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL167032 | 57526 | 0 | None | 25 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 415 | 7 | 2 | 4 | 3.6 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
72545010 | 92693 | 0 | None | 7 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 437 | 6 | 3 | 10 | -0.4 | COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443003 | 92693 | 0 | None | 7 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 437 | 6 | 3 | 10 | -0.4 | COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
44319102 | 204421 | 0 | None | 2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 321 | 4 | 0 | 4 | 2.7 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL86060 | 204421 | 0 | None | 2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 321 | 4 | 0 | 4 | 2.7 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
45483654 | 196441 | 0 | None | -14 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1047 | 23 | 2 | 14 | 8.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1 | 10.1021/jm901120h | ||
CHEMBL574569 | 196441 | 0 | None | -14 | 5 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1047 | 23 | 2 | 14 | 8.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1 | 10.1021/jm901120h | ||
135545150 | 38236 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 341 | 3 | 2 | 5 | 3.6 | Clc1ccc2c(c1)C(NCCN1CCCC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL146410 | 38236 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 341 | 3 | 2 | 5 | 3.6 | Clc1ccc2c(c1)C(NCCN1CCCC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
71658076 | 89971 | 0 | None | -38 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 463 | 9 | 1 | 5 | 5.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(-c3ccccc3)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386615 | 89971 | 0 | None | -38 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 463 | 9 | 1 | 5 | 5.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(-c3ccccc3)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
60165539 | 75002 | 0 | None | 5 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 399 | 6 | 0 | 5 | 4.7 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037524 | 75002 | 0 | None | 5 | 3 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 399 | 6 | 0 | 5 | 4.7 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL5075990 | 212636 | 0 | None | -31 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CCc1cc(Cl)c(OC)c(C(=O)NCC2CCCN2CCCCNCCC(C(=O)N(C)C)(c2ccccc2)c2ccccc2)c1O | 10.1021/acs.jmedchem.1c00611 | ||||
168291477 | 191284 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccccc3C)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5199649 | 191284 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 343 | 6 | 0 | 3 | 4.3 | COc1ccc(CN2CCC[C@H](OCc3ccccc3C)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
42626318 | 55943 | 0 | None | -3090 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
CHEMBL1627306 | 55943 | 0 | None | -3090 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
49799693 | 14280 | 0 | None | -25 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 446 | 6 | 2 | 3 | 4.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ccc(OCCF)cc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173366 | 14280 | 0 | None | -25 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 446 | 6 | 2 | 3 | 4.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ccc(OCCF)cc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200278 | 14280 | 0 | None | -25 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 446 | 6 | 2 | 3 | 4.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ccc(OCCF)cc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
11144835 | 119188 | 0 | None | -114 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 449 | 9 | 1 | 4 | 4.7 | COc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL347290 | 119188 | 0 | None | -114 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 449 | 9 | 1 | 4 | 4.7 | COc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
127051843 | 140220 | 0 | None | -15 | 9 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818200 | 140220 | 0 | None | -15 | 9 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
44395714 | 12756 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 385 | 6 | 0 | 2 | 5.9 | O=C(CCCN1C2CCC1CC(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL1188714 | 12756 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 385 | 6 | 0 | 2 | 5.9 | O=C(CCCN1C2CCC1CC(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL537182 | 12756 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 385 | 6 | 0 | 2 | 5.9 | O=C(CCCN1C2CCC1CC(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
11849181 | 79650 | 0 | None | -2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | CO/N=C(/c1ccc(Cl)cc1)C(C)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
CHEMBL213004 | 79650 | 0 | None | -2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | CO/N=C(/c1ccc(Cl)cc1)C(C)CN1CCN(c2ccccn2)CC1 | 10.1021/jm060279f | ||
60165411 | 75007 | 0 | None | -95 | 5 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 381 | 7 | 0 | 7 | 3.3 | O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037529 | 75007 | 0 | None | -95 | 5 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 381 | 7 | 0 | 7 | 3.3 | O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
22727356 | 13215 | 0 | None | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 387 | 8 | 0 | 4 | 5.0 | C(=C/c1cc(CCCCN2CCN(c3ccccc3)CC2)on1)\c1ccccc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1192095 | 13215 | 0 | None | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 387 | 8 | 0 | 4 | 5.0 | C(=C/c1cc(CCCCN2CCN(c3ccccc3)CC2)on1)\c1ccccc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL543277 | 13215 | 0 | None | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 387 | 8 | 0 | 4 | 5.0 | C(=C/c1cc(CCCCN2CCN(c3ccccc3)CC2)on1)\c1ccccc1 | 10.1016/s0960-894x(02)00179-8 | ||
127051843 | 140220 | 0 | None | -15 | 9 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818200 | 140220 | 0 | None | -15 | 9 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
44438220 | 93017 | 0 | None | -4 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 381 | 4 | 2 | 2 | 4.4 | CC(=O)NC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246021 | 93017 | 0 | None | -4 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 381 | 4 | 2 | 2 | 4.4 | CC(=O)NC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
12066265 | 96664 | 0 | None | -1 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 487 | 6 | 0 | 2 | 7.6 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2ccc(Cl)c(Cl)c2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
CHEMBL267562 | 96664 | 0 | None | -1 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 487 | 6 | 0 | 2 | 7.6 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2ccc(Cl)c(Cl)c2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
44339953 | 109212 | 0 | None | 3 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 387 | 5 | 2 | 4 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL322802 | 109212 | 0 | None | 3 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 387 | 5 | 2 | 4 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C | 10.1016/s0960-894x(03)00678-4 | ||
10436653 | 32573 | 0 | None | -51 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 521 | 8 | 1 | 4 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1 | 10.1021/jm025558r | ||
CHEMBL141419 | 32573 | 0 | None | -51 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 521 | 8 | 1 | 4 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1 | 10.1021/jm025558r | ||
127031500 | 138820 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3ncn4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792931 | 138820 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 323 | 5 | 0 | 5 | 2.6 | c1ccc(OC[C@@H]2CN(Cc3ncn4ccccc34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
71460561 | 81410 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 4.5 | O=C(c1cnc2ccccc2n1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164346 | 81410 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 4.5 | O=C(c1cnc2ccccc2n1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
127052467 | 140320 | 0 | None | 1 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819494 | 140320 | 0 | None | 1 | 7 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
57391306 | 69816 | 0 | None | 6 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 0 | 2 | 4.9 | [O-][S+](CCCN1CCC(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940407 | 69816 | 0 | None | 6 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 6 | 0 | 2 | 4.9 | [O-][S+](CCCN1CCC(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.12.019 | ||
90644227 | 111288 | 0 | None | -26 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 448 | 8 | 1 | 6 | 4.1 | OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
CHEMBL3287396 | 111288 | 0 | None | -26 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 448 | 8 | 1 | 6 | 4.1 | OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
44436617 | 91129 | 0 | None | -1 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 9 | 1 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL240584 | 91129 | 0 | None | -1 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 9 | 1 | 4 | 4.8 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1 | 10.1016/j.bmc.2007.08.038 | ||
11176211 | 4723 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 372 | 8 | 0 | 6 | 3.3 | CCOc1ccccc1OCC1CN(Cc2ccc([N+](=O)[O-])cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104079 | 4723 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 372 | 8 | 0 | 6 | 3.3 | CCOc1ccccc1OCC1CN(Cc2ccc([N+](=O)[O-])cc2)CCO1 | 10.1021/jm031111m | ||
44283891 | 119685 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.6 | Cc1ccc(N2CCN(CCC3c4ccccc4C(=O)N3C)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL35182 | 119685 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.6 | Cc1ccc(N2CCN(CCC3c4ccccc4C(=O)N3C)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
90644059 | 111538 | 0 | None | 22 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 0 | 3 | 3.9 | O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289643 | 111538 | 0 | None | 22 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 354 | 4 | 0 | 3 | 3.9 | O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
10714184 | 78192 | 0 | None | 1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.1 | CC1(C(=O)/C=C(\O)c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 | 10.1021/jm970111h | ||
CHEMBL2112284 | 78192 | 0 | None | 1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.1 | CC1(C(=O)/C=C(\O)c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 | 10.1021/jm970111h | ||
10972865 | 202033 | 0 | None | -3 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 5.5 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm010146o | ||
CHEMBL67750 | 202033 | 0 | None | -3 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 5.5 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm010146o | ||
71657947 | 89966 | 0 | None | -93 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 415 | 8 | 1 | 4 | 4.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386610 | 89966 | 0 | None | -93 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 415 | 8 | 1 | 4 | 4.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
145986441 | 166619 | 0 | None | -102 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 432 | 7 | 2 | 4 | 3.7 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4291172 | 166619 | 0 | None | -102 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 432 | 7 | 2 | 4 | 3.7 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
12050198 | 198570 | 0 | None | 17 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 347 | 6 | 1 | 4 | 4.1 | c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL59702 | 198570 | 0 | None | 17 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 347 | 6 | 1 | 4 | 4.1 | c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
92716 | 71988 | 20 | None | 5 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 2 | 4 | 5 | 2.3 | CN1CCc2cc(O)c(O)cc2C1Cc1ccc(O)c(O)c1 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL19844 | 71988 | 20 | None | 5 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 301 | 2 | 4 | 5 | 2.3 | CN1CCc2cc(O)c(O)cc2C1Cc1ccc(O)c(O)c1 | 10.1016/S0960-894X(97)00194-7 | ||
44381286 | 119861 | 0 | None | -1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 442 | 5 | 1 | 5 | 3.4 | COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL353220 | 119861 | 0 | None | -1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 442 | 5 | 1 | 5 | 3.4 | COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
380039 | 14193 | 4 | None | -5 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 3 | 0 | 4 | 4.2 | CN1CN(c2ccccc2)C2(CCN(Cc3csc4ccccc34)CC2)C1=O | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1169728 | 14193 | 4 | None | -5 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 3 | 0 | 4 | 4.2 | CN1CN(c2ccccc2)C2(CCN(Cc3csc4ccccc34)CC2)C1=O | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1199909 | 14193 | 4 | None | -5 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 3 | 0 | 4 | 4.2 | CN1CN(c2ccccc2)C2(CCN(Cc3csc4ccccc34)CC2)C1=O | 10.1016/j.bmc.2010.05.052 | ||
44438224 | 154099 | 0 | None | -60 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 396 | 5 | 1 | 3 | 4.9 | CCOC(=O)C1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL399396 | 154099 | 0 | None | -60 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 396 | 5 | 1 | 3 | 4.9 | CCOC(=O)C1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
122180570 | 121208 | 0 | None | -114 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 430 | 8 | 1 | 6 | 3.9 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc4[nH]ccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588915 | 121208 | 0 | None | -114 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 430 | 8 | 1 | 6 | 3.9 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc4[nH]ccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
44438199 | 150787 | 3 | None | -27 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | OC1(c2cccc(Cl)c2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL396092 | 150787 | 3 | None | -27 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | OC1(c2cccc(Cl)c2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL5091479 | 213536 | 1 | None | -4 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | None | None | None | CN1CCC(c2ccccc2)(c2ccccc2)C1 | 10.1021/acs.jmedchem.1c00611 | ||||
44330585 | 206567 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 300 | 2 | 0 | 3 | 4.8 | CCCn1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL99085 | 206567 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 300 | 2 | 0 | 3 | 4.8 | CCCn1ncc2c1-c1c(Cl)sc(Cl)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
130431325 | 171846 | 0 | None | -2290 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 8 | 1 | 4 | 5.0 | CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4476699 | 171846 | 0 | None | -2290 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 8 | 1 | 4 | 5.0 | CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
11809415 | 120450 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 321 | 0 | 1 | 5 | 3.2 | Cc1ccc2c(c1)C(N1CCCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL356171 | 120450 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 321 | 0 | 1 | 5 | 3.2 | Cc1ccc2c(c1)C(N1CCCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
11784937 | 121361 | 12 | None | -11220 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 4.7 | Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)n1C | 10.1021/jm501512b | ||
CHEMBL3590085 | 121361 | 12 | None | -11220 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 4.7 | Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)n1C | 10.1021/jm501512b | ||
155195496 | 170149 | 0 | None | -72 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 407 | 7 | 3 | 5 | 3.1 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CCCCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4452064 | 170149 | 0 | None | -72 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 407 | 7 | 3 | 5 | 3.1 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CCCCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
10063875 | 101851 | 0 | None | -389 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 308 | 4 | 2 | 3 | 2.7 | O=C1Cc2c(ccc3c2O[C@@H](CNCc2ccccc2)CC3)N1 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL303556 | 101851 | 0 | None | -389 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 308 | 4 | 2 | 3 | 2.7 | O=C1Cc2c(ccc3c2O[C@@H](CNCc2ccccc2)CC3)N1 | 10.1016/s0960-894x(01)00778-8 | ||
56675269 | 66077 | 1 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 409 | 8 | 1 | 5 | 3.6 | COc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)cc1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813585 | 66077 | 1 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 409 | 8 | 1 | 5 | 3.6 | COc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)cc1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851858 | 66077 | 1 | None | -3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 409 | 8 | 1 | 5 | 3.6 | COc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)cc1 | 10.1016/j.bmc.2011.04.021 | ||
44394599 | 65902 | 0 | None | 85 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 384 | 6 | 1 | 3 | 4.2 | O=Cc1ccccc1-c1ccc(C(=O)NC2CCN(Cc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL184551 | 65902 | 0 | None | 85 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 384 | 6 | 1 | 3 | 4.2 | O=Cc1ccccc1-c1ccc(C(=O)NC2CCN(Cc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9810396 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9810396 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9810396 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9810396 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9810396 | ||
44436301 | 90201 | 0 | None | 4 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 433 | 6 | 0 | 5 | 3.1 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2021.128028 | ||
CHEMBL238915 | 90201 | 0 | None | 4 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 433 | 6 | 0 | 5 | 3.1 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2021.128028 | ||
10472143 | 118772 | 0 | None | -81 | 16 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
CHEMBL343755 | 118772 | 0 | None | -81 | 16 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
9867004 | 168702 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 4 | 0 | 3 | 4.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2CC12CCCC2 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL441274 | 168702 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 4 | 0 | 3 | 4.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2CC12CCCC2 | 10.1016/s0960-894x(02)00655-8 | ||
155529568 | 170887 | 0 | None | 3 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 6 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4463276 | 170887 | 0 | None | 3 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 6 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
155554837 | 174064 | 0 | None | -2 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 4 | 0 | 4 | 3.8 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4558031 | 174064 | 0 | None | -2 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 4 | 0 | 4 | 3.8 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
127031201 | 138845 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1ccc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793131 | 138845 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.5 | COc1ccc(CN2CCO[C@H](COc3cccc(C#N)c3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
127031513 | 138944 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794287 | 138944 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)c1 | 10.1016/j.bmcl.2016.03.102 | ||
90644059 | 111538 | 0 | None | 22 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 354 | 4 | 0 | 3 | 3.9 | O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289643 | 111538 | 0 | None | 22 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 354 | 4 | 0 | 3 | 3.9 | O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
16725931 | 150508 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2cccc(Br)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL395867 | 150508 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2cccc(Br)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
122181327 | 121354 | 0 | None | -50 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 431 | 8 | 1 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)c(F)c2)CC1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590078 | 121354 | 0 | None | -50 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 431 | 8 | 1 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)c(F)c2)CC1 | 10.1016/j.bmc.2014.12.012 | ||
3802 | 201334 | 16 | None | -1 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 307 | 0 | 1 | 5 | 2.8 | Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL63329 | 201334 | 16 | None | -1 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 307 | 0 | 1 | 5 | 2.8 | Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
72737723 | 2541 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 10.1021/ml500267c | ||
8440 | 2541 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 10.1021/ml500267c | ||
CHEMBL3335556 | 2541 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 10.1021/ml500267c | ||
155554837 | 174064 | 0 | None | -2 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 4 | 0 | 4 | 3.8 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4558031 | 174064 | 0 | None | -2 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 4 | 0 | 4 | 3.8 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1 | 10.1016/j.bmc.2020.115943 | ||
76318473 | 105813 | 0 | None | -95 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 510 | 13 | 2 | 6 | 3.7 | COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3cc(OCCOCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3133868 | 105813 | 0 | None | -95 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 510 | 13 | 2 | 6 | 3.7 | COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3cc(OCCOCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3139054 | 105813 | 0 | None | -95 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 510 | 13 | 2 | 6 | 3.7 | COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3cc(OCCOCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
57393627 | 68965 | 0 | None | -40 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1101 | 42 | 2 | 17 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928131 | 68965 | 0 | None | -40 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1101 | 42 | 2 | 17 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
118709162 | 112909 | 0 | None | -125 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 874 | 20 | 0 | 8 | 10.9 | O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318834 | 112909 | 0 | None | -125 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 874 | 20 | 0 | 8 | 10.9 | O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
45270861 | 193410 | 0 | None | 11 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 353 | 3 | 0 | 5 | 3.1 | Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL549638 | 193410 | 0 | None | 11 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 353 | 3 | 0 | 5 | 3.1 | Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
11078813 | 111526 | 0 | None | 6 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1021/jm015522j | ||
CHEMBL328925 | 111526 | 0 | None | 6 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.8 | OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1021/jm015522j | ||
10973768 | 107074 | 0 | None | -9332 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 563 | 6 | 1 | 8 | 4.4 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL318901 | 107074 | 0 | None | -9332 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 563 | 6 | 1 | 8 | 4.4 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
10276451 | 198601 | 33 | None | -2754 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
CHEMBL2112910 | 198601 | 33 | None | -2754 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
CHEMBL59725 | 198601 | 33 | None | -2754 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1 | 10.1021/jm040190e | ||
71086303 | 160263 | 0 | None | -1 | 2 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 373 | 6 | 0 | 5 | 2.9 | Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL4114493 | 160263 | 0 | None | -1 | 2 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 373 | 6 | 0 | 5 | 2.9 | Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
168293874 | 191581 | 0 | None | -83 | 11 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 2 | 3 | 3 | 3.3 | COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | ||
CHEMBL5204071 | 191581 | 0 | None | -83 | 11 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 2 | 3 | 3 | 3.3 | COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | ||
44426502 | 141534 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 386 | 7 | 1 | 2 | 5.1 | O=C(NC1CCN(CCCCc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL387952 | 141534 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 386 | 7 | 1 | 2 | 5.1 | O=C(NC1CCN(CCCCc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
44309688 | 202294 | 0 | None | -19 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2 | 10.1021/jm040190e | ||
CHEMBL69571 | 202294 | 0 | None | -19 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.7 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2 | 10.1021/jm040190e | ||
25132869 | 102820 | 0 | None | -57 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 400 | 3 | 2 | 2 | 5.5 | O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12 | 10.1021/jm800532x | ||
CHEMBL3084503 | 102820 | 0 | None | -57 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 400 | 3 | 2 | 2 | 5.5 | O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12 | 10.1021/jm800532x | ||
44438221 | 148247 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 342 | 3 | 1 | 1 | 5.3 | FC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL394065 | 148247 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 342 | 3 | 1 | 1 | 5.3 | FC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
122181007 | 121282 | 0 | None | -15848 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 509 | 7 | 2 | 4 | 4.9 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)-c1ccccc1C2 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3589652 | 121282 | 0 | None | -15848 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 509 | 7 | 2 | 4 | 4.9 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)-c1ccccc1C2 | 10.1016/j.bmc.2015.01.017 | ||
6674 | 2777 | 14 | None | -3019 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 493 | 7 | 1 | 3 | 5.9 | O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
9891901 | 2777 | 14 | None | -3019 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 493 | 7 | 1 | 3 | 5.9 | O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
CHEMBL300780 | 2777 | 14 | None | -3019 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 493 | 7 | 1 | 3 | 5.9 | O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
11812065 | 202322 | 5 | None | -91 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 431 | 6 | 0 | 4 | 4.2 | O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/jm010146o | ||
CHEMBL69717 | 202322 | 5 | None | -91 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 431 | 6 | 0 | 4 | 4.2 | O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1 | 10.1021/jm010146o | ||
CHEMBL5077645 | 212738 | 0 | None | -97723 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | None | None | None | Oc1cccc([C@@]23CCC[C@@H]([C@H]2O)N(C/C=C/c2ccccc2)CC3)c1 | 10.1021/acs.jmedchem.1c00611 | ||||
10403435 | 13339 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | C=CCN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL1193072 | 13339 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | C=CCN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL544418 | 13339 | 0 | None | 1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | C=CCN1CC=C(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
9820313 | 105713 | 0 | None | -1 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 4 | 2 | 3 | 4.1 | FC(F)(F)c1nc2c3c(ccc2[nH]1)CCC(CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL313851 | 105713 | 0 | None | -1 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 4 | 2 | 3 | 4.1 | FC(F)(F)c1nc2c3c(ccc2[nH]1)CCC(CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
44335896 | 5304 | 0 | None | 45 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1ccc2c(c1)CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106998 | 5304 | 0 | None | 45 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1ccc2c(c1)CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44336005 | 5370 | 0 | None | 60 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 415 | 4 | 0 | 3 | 4.0 | CC1CCc2cc(F)ccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107391 | 5370 | 0 | None | 60 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 415 | 4 | 0 | 3 | 4.0 | CC1CCc2cc(F)ccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
57399494 | 70114 | 0 | None | 1 | 8 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 4.4 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL1946124 | 70114 | 0 | None | 1 | 8 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 4.4 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2020.115943 | ||
155564110 | 174797 | 0 | None | -4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 0 | 4 | 4.0 | O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4574793 | 174797 | 0 | None | -4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 0 | 4 | 4.0 | O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
57399494 | 70114 | 0 | None | -1 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 4.4 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946124 | 70114 | 0 | None | -1 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 4.4 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2012.01.022 | ||
134146195 | 154054 | 0 | None | -3 | 9 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 362 | 5 | 0 | 3 | 5.8 | Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3941795 | 154054 | 0 | None | -3 | 9 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 362 | 5 | 0 | 3 | 5.8 | Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991399 | 154054 | 0 | None | -3 | 9 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 362 | 5 | 0 | 3 | 5.8 | Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
127032084 | 138811 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3cccc4cc[nH]c34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792813 | 138811 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OC[C@@H]2CN(Cc3cccc4cc[nH]c34)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127031830 | 138902 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793906 | 138902 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.1 | Clc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
10385977 | 96882 | 0 | None | -5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | COc1ccccc1N1CCN(CCCC2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL26929 | 96882 | 0 | None | -5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | COc1ccccc1N1CCN(CCCC2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
44431479 | 87152 | 2 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL233581 | 87152 | 2 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
122189387 | 122726 | 0 | None | 2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 7 | 0 | 8 | 2.7 | COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613873 | 122726 | 0 | None | 2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 7 | 0 | 8 | 2.7 | COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1 | 10.1016/j.bmc.2015.07.050 | ||
71734028 | 90622 | 0 | None | -11 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397390 | 90622 | 0 | None | -11 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 9 | 1 | 4 | 3.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm400520c | ||
11079832 | 164361 | 0 | None | 16 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 397 | 3 | 1 | 5 | 4.4 | Cc1ccc2c(c1)C(N1CCN(CCc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL422310 | 164361 | 0 | None | 16 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 397 | 3 | 1 | 5 | 4.4 | Cc1ccc2c(c1)C(N1CCN(CCc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
44372153 | 119659 | 0 | None | 83 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 416 | 4 | 0 | 4 | 5.3 | Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL351550 | 119659 | 0 | None | 83 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 416 | 4 | 0 | 4 | 5.3 | Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
57399494 | 70114 | 0 | None | 1 | 8 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 4.4 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL1946124 | 70114 | 0 | None | 1 | 8 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 4.4 | O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2020.115943 | ||
155564110 | 174797 | 0 | None | -4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 0 | 4 | 4.0 | O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4574793 | 174797 | 0 | None | -4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 0 | 4 | 4.0 | O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
134146195 | 154054 | 0 | None | -3 | 9 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 362 | 5 | 0 | 3 | 5.8 | Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3941795 | 154054 | 0 | None | -3 | 9 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 362 | 5 | 0 | 3 | 5.8 | Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991399 | 154054 | 0 | None | -3 | 9 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 362 | 5 | 0 | 3 | 5.8 | Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
139877715 | 192220 | 0 | None | 21 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 321 | 5 | 0 | 4 | 3.6 | c1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5179879 | 192220 | 0 | None | 21 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 321 | 5 | 0 | 4 | 3.6 | c1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221531 | 192220 | 0 | None | 21 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 321 | 5 | 0 | 4 | 3.6 | c1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
9906454 | 137743 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 351 | 5 | 1 | 4 | 2.7 | COc1ccc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL37706 | 137743 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 351 | 5 | 1 | 4 | 2.7 | COc1ccc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
10939408 | 47159 | 0 | None | -645 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1 | 10.1021/jm020952a | ||
CHEMBL154508 | 47159 | 0 | None | -645 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 5.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1 | 10.1021/jm020952a | ||
12050197 | 100407 | 0 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 457 | 6 | 0 | 5 | 4.9 | COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL293645 | 100407 | 0 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 457 | 6 | 0 | 5 | 4.9 | COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
12049521 | 201501 | 0 | None | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 427 | 5 | 0 | 5 | 4.4 | COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64288 | 201501 | 0 | None | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 427 | 5 | 0 | 5 | 4.4 | COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
44381276 | 58420 | 0 | None | 2 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 2.1 | O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL168541 | 58420 | 0 | None | 2 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 2.1 | O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
3228 | 3097 | 17 | None | -4168 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1016/j.ejmech.2020.113073 | ||
9909448 | 3097 | 17 | None | -4168 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1016/j.ejmech.2020.113073 | ||
CHEMBL71838 | 3097 | 17 | None | -4168 | 7 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 2.9 | CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC | 10.1016/j.ejmech.2020.113073 | ||
10086348 | 7969 | 0 | None | -144 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)nc1 | 10.1021/jm950721m | ||
CHEMBL109101 | 7969 | 0 | None | -144 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)nc1 | 10.1021/jm950721m | ||
10086348 | 7969 | 0 | None | -144 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)nc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL109101 | 7969 | 0 | None | -144 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 3.2 | Nc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)nc1 | 10.1016/j.bmcl.2005.02.012 | ||
164619127 | 184943 | 0 | None | -32 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 428 | 10 | 2 | 4 | 4.8 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4862770 | 184943 | 0 | None | -32 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 428 | 10 | 2 | 4 | 4.8 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2 | 10.1021/acs.jmedchem.1c01327 | ||
71657943 | 89962 | 0 | None | -128 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 427 | 9 | 1 | 5 | 4.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(SC)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386606 | 89962 | 0 | None | -128 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 427 | 9 | 1 | 5 | 4.1 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(SC)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
10254390 | 71344 | 0 | None | -2884 | 8 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 475 | 8 | 1 | 5 | 5.1 | COc1cccc2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)oc12 | 10.1021/jm050171k | ||
CHEMBL196476 | 71344 | 0 | None | -2884 | 8 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 475 | 8 | 1 | 5 | 5.1 | COc1cccc2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)oc12 | 10.1021/jm050171k | ||
164619127 | 184943 | 0 | None | -32 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 428 | 10 | 2 | 4 | 4.8 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4862770 | 184943 | 0 | None | -32 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 428 | 10 | 2 | 4 | 4.8 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2 | 10.1021/acs.jmedchem.1c01327 | ||
168277394 | 189807 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5177641 | 189807 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
6917970 | 3635 | 54 | None | -851 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | 10.1016/j.bmc.2009.08.028 | ||
8370 | 3635 | 54 | None | -851 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL487387 | 3635 | 54 | None | -851 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | 10.1016/j.bmc.2009.08.028 | ||
11477180 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm049465g | ||
6675 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm049465g | ||
CHEMBL180010 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm049465g | ||
11778580 | 65796 | 1 | None | -645 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 283 | 0 | 1 | 3 | 2.9 | CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm049720x | ||
CHEMBL184050 | 65796 | 1 | None | -645 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 283 | 0 | 1 | 3 | 2.9 | CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm049720x | ||
11477180 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm200288r | ||
6675 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm200288r | ||
CHEMBL180010 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm200288r | ||
11477180 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0704200 | ||
6675 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0704200 | ||
CHEMBL180010 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0704200 | ||
11477180 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm040190e | ||
6675 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm040190e | ||
CHEMBL180010 | 3025 | 3 | None | -616 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm040190e | ||
44438203 | 93222 | 2 | None | -34 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 374 | 3 | 2 | 2 | 4.7 | OC1(c2cccc(C(F)(F)F)c2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246848 | 93222 | 2 | None | -34 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 374 | 3 | 2 | 2 | 4.7 | OC1(c2cccc(C(F)(F)F)c2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
17756213 | 149172 | 1 | None | -58 | 5 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm070388+ | ||
CHEMBL394779 | 149172 | 1 | None | -58 | 5 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm070388+ | ||
11300847 | 203282 | 1 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1cncc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm0305669 | ||
CHEMBL76653 | 203282 | 1 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 293 | 3 | 1 | 4 | 2.3 | c1cncc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm0305669 | ||
154706431 | 176011 | 1 | None | -33 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 451 | 12 | 2 | 3 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4531363 | 176011 | 1 | None | -33 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 451 | 12 | 2 | 3 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597531 | 176011 | 1 | None | -33 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 451 | 12 | 2 | 3 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
49798833 | 14245 | 0 | None | -8 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 323 | 3 | 1 | 3 | 4.4 | OC1(c2ccccc2)CCN(Cc2cc3ccccc3s2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1172212 | 14245 | 0 | None | -8 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 323 | 3 | 1 | 3 | 4.4 | OC1(c2ccccc2)CCN(Cc2cc3ccccc3s2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200152 | 14245 | 0 | None | -8 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 323 | 3 | 1 | 3 | 4.4 | OC1(c2ccccc2)CCN(Cc2cc3ccccc3s2)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL5073754 | 212534 | 0 | None | -15 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | CN(C)C(=O)C(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
11716449 | 140684 | 0 | None | -20 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 304 | 1 | 1 | 1 | 4.2 | CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm050846j | ||
CHEMBL382850 | 140684 | 0 | None | -20 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 304 | 1 | 1 | 1 | 4.2 | CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm050846j | ||
4420454 | 55966 | 6 | None | 1 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
CHEMBL162762 | 55966 | 6 | None | 1 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
10548105 | 18682 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 9 | 1 | 3 | 4.5 | Clc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1021/jm970422s | ||
CHEMBL128222 | 18682 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 9 | 1 | 3 | 4.5 | Clc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1021/jm970422s | ||
11256262 | 79591 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 338 | 7 | 0 | 5 | 3.0 | CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL212782 | 79591 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 338 | 7 | 0 | 5 | 3.0 | CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
56837636 | 68955 | 0 | None | -26 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 897 | 28 | 2 | 13 | 5.1 | COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928121 | 68955 | 0 | None | -26 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 897 | 28 | 2 | 13 | 5.1 | COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
127046952 | 139571 | 0 | None | -3 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 421 | 12 | 3 | 5 | 4.5 | COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3800636 | 139571 | 0 | None | -3 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 421 | 12 | 3 | 5 | 4.5 | COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
10548105 | 18682 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 9 | 1 | 3 | 4.5 | Clc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL128222 | 18682 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 9 | 1 | 3 | 4.5 | Clc1ccc(OCCNCCCOc2ccc(Br)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
11199162 | 79449 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL212235 | 79449 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.3 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
12899499 | 66290 | 0 | None | -7 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 7 | 1 | 5 | 3.2 | COc1ccccc1N1CCN(CCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813596 | 66290 | 0 | None | -7 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 7 | 1 | 5 | 3.2 | COc1ccccc1N1CCN(CCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1852734 | 66290 | 0 | None | -7 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 7 | 1 | 5 | 3.2 | COc1ccccc1N1CCN(CCCOc2ccc3c(c2)NC(=O)CC3)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL5083473 | 213093 | 0 | None | 5 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | None | None | None | CCc1cccc(N2CCN(CCC(c3cccc(O)c3)c3cccc(OC)c3)CC2)c1Cl | 10.1021/acs.jmedchem.1c00611 | ||||
3038495 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm0611152 | ||
7625 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm0611152 | ||
CHEMBL25236 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm0611152 | ||
4420454 | 55966 | 6 | None | 1 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
CHEMBL162762 | 55966 | 6 | None | 1 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 205 | 5 | 0 | 1 | 3.2 | C#CC1=CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
11615489 | 69100 | 1 | None | -3 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@H]1CCn2nccc2C1 | 10.1021/jm101639t | ||
CHEMBL193337 | 69100 | 1 | None | -3 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@H]1CCn2nccc2C1 | 10.1021/jm101639t | ||
10039198 | 56055 | 0 | None | -4 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
CHEMBL163087 | 56055 | 0 | None | -4 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
CHEMBL5072449 | 212510 | 0 | None | -8 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | None | None | None | O=C(NCCCCN1CC[C@]2(c3cccc(O)c3)CCC[C@H]1[C@H]2O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.1c00611 | ||||
90389592 | 147141 | 0 | None | -12 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 422 | 8 | 1 | 4 | 2.8 | CC(O)CN1CCN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL3931765 | 147141 | 0 | None | -12 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 422 | 8 | 1 | 4 | 2.8 | CC(O)CN1CCN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
90389592 | 147141 | 0 | None | -12 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 422 | 8 | 1 | 4 | 2.8 | CC(O)CN1CCN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.6b01373 | ||
CHEMBL3931765 | 147141 | 0 | None | -12 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 422 | 8 | 1 | 4 | 2.8 | CC(O)CN1CCN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.6b01373 | ||
154705520 | 175686 | 1 | None | -25 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 448 | 11 | 1 | 3 | 5.6 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4452683 | 175686 | 1 | None | -25 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 448 | 11 | 1 | 3 | 5.6 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4594959 | 175686 | 1 | None | -25 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 448 | 11 | 1 | 3 | 5.6 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
71455083 | 81418 | 0 | None | -239 | 7 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 389 | 6 | 0 | 3 | 4.8 | O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164354 | 81418 | 0 | None | -239 | 7 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 389 | 6 | 0 | 3 | 4.8 | O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
53325242 | 56775 | 0 | None | -1 | 17 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 537 | 8 | 1 | 2 | 7.9 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL1644978 | 56775 | 0 | None | -1 | 17 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 537 | 8 | 1 | 2 | 7.9 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
9907381 | 4828 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCc2ccccc21)N1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104514 | 4828 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.0 | O=C(CN1CCc2ccccc21)N1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
72191064 | 91927 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 469 | 8 | 0 | 6 | 4.3 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(Br)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
CHEMBL2430442 | 91927 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 469 | 8 | 0 | 6 | 4.3 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(Br)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
44438211 | 146929 | 2 | None | -19 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 354 | 3 | 2 | 2 | 4.7 | OC1(c2ccc(Cl)cc2)CCCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL393027 | 146929 | 2 | None | -19 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 354 | 3 | 2 | 2 | 4.7 | OC1(c2ccc(Cl)cc2)CCCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
54477 | 84230 | 34 | None | -14 | 22 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | 10.1021/jm00025a013 | ||
CHEMBL22242 | 84230 | 34 | None | -14 | 22 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | 10.1021/jm00025a013 | ||
3038495 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm025558r | ||
7625 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm025558r | ||
CHEMBL25236 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm025558r | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
2865 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
59 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
60854 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
CHEMBL708 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
DB00246 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
103 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
2875 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
5736 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
CHEMBL285802 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
DB09225 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
2865 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
59 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
60854 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
CHEMBL708 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
DB00246 | 4079 | 67 | None | -66 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
103 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
2875 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
5736 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
CHEMBL285802 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
DB09225 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | ||
57394810 | 69814 | 0 | None | 2 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 6 | 0 | 2 | 5.8 | Fc1ccc(SCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940405 | 69814 | 0 | None | 2 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 6 | 0 | 2 | 5.8 | Fc1ccc(SCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
49782601 | 17306 | 0 | None | -2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 6.2 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
CHEMBL1257810 | 17306 | 0 | None | -2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 6.2 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2 | 10.1021/jm100899z | ||
45267409 | 194487 | 0 | None | 676 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL561262 | 194487 | 0 | None | 676 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
9906895 | 119451 | 1 | None | 25 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(OC[C@@H]2CC[C@@H]3CN(c4ncc(F)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL349699 | 119451 | 1 | None | 25 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(OC[C@@H]2CC[C@@H]3CN(c4ncc(F)cn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
12050202 | 201607 | 0 | None | 43 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.5 | COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64752 | 201607 | 0 | None | 43 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.5 | COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
45379369 | 7441 | 0 | None | -15 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 | 10.1021/jm901291r | ||
CHEMBL1087300 | 7441 | 0 | None | -15 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 | 10.1021/jm901291r | ||
8592415 | 64838 | 7 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1cccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL182432 | 64838 | 7 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1cccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
10477871 | 82817 | 0 | None | -158 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 431 | 8 | 2 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc(C#N)cc3[nH]2)CC1 | 10.1021/jm0611152 | ||
CHEMBL218638 | 82817 | 0 | None | -158 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 431 | 8 | 2 | 5 | 3.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc(C#N)cc3[nH]2)CC1 | 10.1021/jm0611152 | ||
11570589 | 83833 | 0 | None | -18 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 582 | 13 | 1 | 7 | 4.8 | CCCc1c(C(=O)NCCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccccc1Br | 10.1021/jm0611152 | ||
CHEMBL221129 | 83833 | 0 | None | -18 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 582 | 13 | 1 | 7 | 4.8 | CCCc1c(C(=O)NCCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccccc1Br | 10.1021/jm0611152 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
4064342 | 205312 | 29 | None | -4 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 4 | 2 | 2 | 3.5 | O=C(Nc1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL91621 | 205312 | 29 | None | -4 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 4 | 2 | 2 | 3.5 | O=C(Nc1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
12050199 | 100345 | 0 | None | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 4.9 | COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL293225 | 100345 | 0 | None | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 4.9 | COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
44304652 | 198638 | 0 | None | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 363 | 7 | 1 | 4 | 4.4 | c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL59749 | 198638 | 0 | None | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 363 | 7 | 1 | 4 | 4.4 | c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
44319368 | 105584 | 0 | None | -1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 429 | 5 | 0 | 5 | 3.4 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL313320 | 105584 | 0 | None | -1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 429 | 5 | 0 | 5 | 3.4 | COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1 | 10.1016/s0960-894x(01)00484-x | ||
10824155 | 56944 | 1 | None | 1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 243 | 5 | 0 | 1 | 3.6 | C#CC(C#C)=C1CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
CHEMBL165022 | 56944 | 1 | None | 1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 243 | 5 | 0 | 1 | 3.6 | C#CC(C#C)=C1CCC(N(CCC)CCC)CC1 | 10.1021/jm991098z | ||
164622629 | 185014 | 0 | None | -20 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 436 | 6 | 2 | 4 | 4.5 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccccc1Cl)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4863748 | 185014 | 0 | None | -20 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 436 | 6 | 2 | 4 | 4.5 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccccc1Cl)CC2 | 10.1016/j.bmcl.2021.128047 | ||
10885524 | 102651 | 0 | None | -38 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 493 | 7 | 1 | 3 | 5.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)C1c2ccccc2-c2ccccc21 | 10.1021/jm010146o | ||
CHEMBL307800 | 102651 | 0 | None | -38 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 493 | 7 | 1 | 3 | 5.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)C1c2ccccc2-c2ccccc21 | 10.1021/jm010146o | ||
10572985 | 162930 | 0 | None | 1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 398 | 6 | 0 | 3 | 5.4 | COc1ccc2c(c1)C(CCCN1CCN(c3ccc(Cl)cc3)CC1)CCC2 | 10.1021/jm991138z | ||
CHEMBL420067 | 162930 | 0 | None | 1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 398 | 6 | 0 | 3 | 5.4 | COc1ccc2c(c1)C(CCCN1CCN(c3ccc(Cl)cc3)CC1)CCC2 | 10.1021/jm991138z | ||
1016 | 3690 | 75 | None | -28 | 35 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2561 | 3690 | 75 | None | -28 | 35 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2733526 | 3690 | 75 | None | -28 | 35 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
5384 | 3690 | 75 | None | -28 | 35 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
CHEMBL83 | 3690 | 75 | None | -28 | 35 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
DB00675 | 3690 | 75 | None | -28 | 35 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
71061611 | 148528 | 0 | None | -10 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 3.0 | Fc1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 | nan | ||
CHEMBL3942898 | 148528 | 0 | None | -10 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 3.0 | Fc1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 | nan | ||
155522719 | 170223 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 298 | 4 | 1 | 6 | 0.6 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cncnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4453069 | 170223 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 298 | 4 | 1 | 6 | 0.6 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cncnc1 | 10.1021/acs.jmedchem.9b00231 | ||
135404757 | 120445 | 0 | None | 2 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 341 | 1 | 2 | 5 | 3.6 | CN1CCC(NC2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm0104825 | ||
CHEMBL356149 | 120445 | 0 | None | 2 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 341 | 1 | 2 | 5 | 3.6 | CN1CCC(NC2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1 | 10.1021/jm0104825 | ||
44438213 | 92976 | 5 | None | -1 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 354 | 4 | 2 | 2 | 4.4 | OC1(Cc2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL245815 | 92976 | 5 | None | -1 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 354 | 4 | 2 | 2 | 4.4 | OC1(Cc2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
44438223 | 93059 | 0 | None | -64 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 382 | 4 | 1 | 3 | 4.5 | COC(=O)C1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246231 | 93059 | 0 | None | -64 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 382 | 4 | 1 | 3 | 4.5 | COC(=O)C1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL5077104 | 212710 | 0 | None | -64 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | None | None | None | N#CC(CCNCCCCC(=O)N1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
70788951 | 26948 | 1 | None | -1 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | nan | ||||
CHEMBL1366 | 26948 | 1 | None | -1 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | nan | ||||
72191065 | 91926 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 421 | 9 | 0 | 7 | 3.6 | COc1ccc(-c2cn(CCCCN3CCN(c4ccccc4OC)CC3)nn2)cc1 | 10.1016/j.bmcl.2013.08.047 | ||
CHEMBL2430441 | 91926 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 421 | 9 | 0 | 7 | 3.6 | COc1ccc(-c2cn(CCCCN3CCN(c4ccccc4OC)CC3)nn2)cc1 | 10.1016/j.bmcl.2013.08.047 | ||
118719798 | 115225 | 0 | None | -309 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 473 | 9 | 0 | 7 | 5.1 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc(-c4ccsc4)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353901 | 115225 | 0 | None | -309 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 473 | 9 | 0 | 7 | 5.1 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc(-c4ccsc4)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
44356253 | 11473 | 0 | None | -794 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)OC(CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
CHEMBL1180604 | 11473 | 0 | None | -794 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)OC(CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
CHEMBL134808 | 11473 | 0 | None | -794 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)OC(CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
46231784 | 199653 | 0 | None | -6606 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 329 | 0 | 2 | 3 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL604314 | 199653 | 0 | None | -6606 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 329 | 0 | 2 | 3 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
11762743 | 103337 | 0 | None | -109 | 5 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 493 | 6 | 1 | 4 | 5.1 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
CHEMBL309118 | 103337 | 0 | None | -109 | 5 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 493 | 6 | 1 | 4 | 5.1 | O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
44394884 | 122144 | 0 | None | 38 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 356 | 5 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1cccc(-c2ccccc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL360394 | 122144 | 0 | None | 38 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 356 | 5 | 1 | 2 | 4.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1cccc(-c2ccccc2)c1 | 10.1016/j.bmcl.2004.07.045 | ||
9951233 | 102317 | 0 | None | 33 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 3.0 | CN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL305276 | 102317 | 0 | None | 33 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 3.0 | CN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
10045525 | 202085 | 0 | None | 5 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL68191 | 202085 | 0 | None | 5 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
44264682 | 96869 | 0 | None | 141 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL269202 | 96869 | 0 | None | 141 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1 | 10.1016/s0960-894x(98)00692-1 | ||
10430183 | 203916 | 0 | None | -39 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 2.1 | O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.2c00633 | ||
CHEMBL81728 | 203916 | 0 | None | -39 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 2.1 | O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.2c00633 | ||
44335995 | 107978 | 0 | None | 54 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 3.8 | CC[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL319923 | 107978 | 0 | None | 54 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 3.8 | CC[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44336000 | 108501 | 0 | None | 288 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccccc2Cl)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL321201 | 108501 | 0 | None | 288 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccccc2Cl)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44336050 | 5242 | 0 | None | 77 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 376 | 4 | 0 | 2 | 4.9 | Cc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1C | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106742 | 5242 | 0 | None | 77 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 376 | 4 | 0 | 2 | 4.9 | Cc1ccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)cc1C | 10.1016/s0960-894x(02)00655-8 | ||
9800164 | 4883 | 0 | None | 22 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.9 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104788 | 4883 | 0 | None | 22 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.9 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335796 | 4896 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.9 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104832 | 4896 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.9 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
9799781 | 119699 | 0 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 3 | 0 | 3 | 3.0 | Cc1ccc(CN2CCN(C3CCc4cccc5c4N(CC5)C3=O)CC2)cc1 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL351963 | 119699 | 0 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 3 | 0 | 3 | 3.0 | Cc1ccc(CN2CCN(C3CCc4cccc5c4N(CC5)C3=O)CC2)cc1 | 10.1016/s0960-894x(02)01056-9 | ||
10045525 | 202085 | 0 | None | 5 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL68191 | 202085 | 0 | None | 5 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1016/s0960-894x(02)01056-9 | ||
10543298 | 39615 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.8 | C1=C(c2ccccc2)CCN(Cc2ccn(-c3ccccc3)c2)C1 | 10.1021/jm00025a013 | ||
CHEMBL147731 | 39615 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.8 | C1=C(c2ccccc2)CCN(Cc2ccn(-c3ccccc3)c2)C1 | 10.1021/jm00025a013 | ||
10567507 | 118755 | 0 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 3.8 | c1ccc(N2CCN(Cc3ccn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm00025a013 | ||
CHEMBL343657 | 118755 | 0 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 3.8 | c1ccc(N2CCN(Cc3ccn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm00025a013 | ||
60165416 | 74946 | 0 | None | 7 | 8 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 6 | 0 | 4 | 5.1 | Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL2037431 | 74946 | 0 | None | 7 | 8 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 6 | 0 | 4 | 5.1 | Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
60165416 | 74946 | 0 | None | 7 | 8 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 6 | 0 | 4 | 5.1 | Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037431 | 74946 | 0 | None | 7 | 8 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 6 | 0 | 4 | 5.1 | Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
44405492 | 139992 | 0 | None | 15 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 376 | 5 | 1 | 3 | 4.7 | Cc1ccc(CN2CC[C@H](NC(=O)c3cccc(-c4cccs4)c3)C2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL381019 | 139992 | 0 | None | 15 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 376 | 5 | 1 | 3 | 4.7 | Cc1ccc(CN2CC[C@H](NC(=O)c3cccc(-c4cccs4)c3)C2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
11638780 | 76742 | 0 | None | 1412 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 345 | 3 | 0 | 5 | 2.8 | Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL207488 | 76742 | 0 | None | 1412 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 345 | 3 | 0 | 5 | 2.8 | Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
10044835 | 110918 | 0 | None | 45 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 372 | 7 | 0 | 4 | 4.1 | COc1cccc(C(=O)CCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL327245 | 110918 | 0 | None | 45 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 372 | 7 | 0 | 4 | 4.1 | COc1cccc(C(=O)CCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
9951233 | 102317 | 0 | None | 33 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 3.0 | CN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL305276 | 102317 | 0 | None | 33 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 3.0 | CN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21 | 10.1021/acs.jmedchem.7b00151 | ||
54583898 | 61282 | 0 | None | -8 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 417 | 7 | 0 | 4 | 3.3 | C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771114 | 61282 | 0 | None | -8 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 417 | 7 | 0 | 4 | 3.3 | C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O | 10.1016/j.bmcl.2010.12.083 | ||
44376569 | 57140 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OC[C@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL165504 | 57140 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 324 | 4 | 0 | 5 | 2.5 | c1ccc(OC[C@H]2CC[C@H]3CN(c4ncccn4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
168286048 | 192320 | 0 | None | 371 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1cccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5191408 | 192320 | 0 | None | 371 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1cccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222229 | 192320 | 0 | None | 371 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1cccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)c1 | 10.1021/acs.jmedchem.2c00840 | ||
57396484 | 69826 | 2 | None | 5 | 6 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 6 | 0 | 5 | 2.2 | Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940417 | 69826 | 2 | None | 5 | 6 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 6 | 0 | 5 | 2.2 | Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57396484 | 69826 | 2 | None | 5 | 6 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 6 | 0 | 5 | 2.2 | Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940417 | 69826 | 2 | None | 5 | 6 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 6 | 0 | 5 | 2.2 | Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
56926585 | 68663 | 0 | None | 1000 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 358 | 4 | 0 | 5 | 2.9 | COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F | 10.1021/jm200762g | ||
CHEMBL1923293 | 68663 | 0 | None | 1000 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 358 | 4 | 0 | 5 | 2.9 | COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F | 10.1021/jm200762g | ||
10090130 | 192391 | 0 | None | 19 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 363 | 6 | 0 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5199358 | 192391 | 0 | None | 19 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 363 | 6 | 0 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5222630 | 192391 | 0 | None | 19 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 363 | 6 | 0 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
44340097 | 9349 | 0 | None | 8 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL111749 | 9349 | 0 | None | 8 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.6 | CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
10759511 | 205236 | 0 | None | 128 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 339 | 3 | 0 | 4 | 3.5 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(F)cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL91273 | 205236 | 0 | None | 128 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 339 | 3 | 0 | 4 | 3.5 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(F)cc1)CC3 | 10.1021/jm970170v | ||
4826074 | 103627 | 6 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
CHEMBL309372 | 103627 | 6 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 322 | 4 | 1 | 4 | 2.9 | COc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
9902381 | 119006 | 0 | None | 114 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 337 | 3 | 1 | 4 | 2.6 | Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL345552 | 119006 | 0 | None | 114 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 337 | 3 | 1 | 4 | 2.6 | Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1 | 10.1021/jm990277d | ||
9885114 | 119099 | 3 | None | 47 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.0 | O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 | 10.1021/jm990277d | ||
CHEMBL346389 | 119099 | 3 | None | 47 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.0 | O=C1COc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)ccc2N1 | 10.1021/jm990277d | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9810396 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9810396 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9810396 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9810396 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9810396 | ||
9887091 | 106905 | 0 | None | 27 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CC1(C)Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL317879 | 106905 | 0 | None | 27 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CC1(C)Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
10023466 | 164362 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 392 | 4 | 1 | 3 | 4.2 | Clc1ccccc1CCN1CCN(c2[nH]nc3c2CCc2ccccc2-3)CC1 | 10.1021/jm0002432 | ||
CHEMBL422314 | 164362 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 392 | 4 | 1 | 3 | 4.2 | Clc1ccccc1CCN1CCN(c2[nH]nc3c2CCc2ccccc2-3)CC1 | 10.1021/jm0002432 | ||
21527771 | 69813 | 0 | None | -1 | 10 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL1940404 | 69813 | 0 | None | -1 | 10 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
25139181 | 183760 | 0 | None | -2 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm800895v | ||
CHEMBL484358 | 183760 | 0 | None | -2 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm800895v | ||
25072941 | 155933 | 0 | None | 1 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 408 | 9 | 0 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4067439 | 155933 | 0 | None | 1 | 5 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 408 | 9 | 0 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
10780942 | 21131 | 1 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccccc1OCCNCCCOc1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL131396 | 21131 | 1 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccccc1OCCNCCCOc1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
10805355 | 22200 | 0 | None | 79 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 10 | 1 | 5 | 3.0 | O=[N+]([O-])c1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL132455 | 22200 | 0 | None | 79 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 10 | 1 | 5 | 3.0 | O=[N+]([O-])c1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
118719926 | 115280 | 0 | None | 102 | 8 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 358 | 9 | 1 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354073 | 115280 | 0 | None | 102 | 8 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 358 | 9 | 1 | 3 | 3.6 | O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
10719212 | 205523 | 0 | None | -2 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 471 | 6 | 2 | 4 | 4.3 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2C3CC4CC(C3)CC2C4)C1 | 10.1021/jm9601720 | ||
CHEMBL92924 | 205523 | 0 | None | -2 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 471 | 6 | 2 | 4 | 4.3 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C2C3CC4CC(C3)CC2C4)C1 | 10.1021/jm9601720 | ||
72164299 | 91721 | 4 | None | 9 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 321 | 3 | 0 | 3 | 3.7 | Clc1cccc(N2CCN(Cc3cccnc3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420780 | 91721 | 4 | None | 9 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 321 | 3 | 0 | 3 | 3.7 | Clc1cccc(N2CCN(Cc3cccnc3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
10780942 | 21131 | 1 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccccc1OCCNCCCOc1ccccc1 | 10.1021/jm970422s | ||
CHEMBL131396 | 21131 | 1 | None | 3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 305 | 9 | 1 | 3 | 3.8 | Clc1ccccc1OCCNCCCOc1ccccc1 | 10.1021/jm970422s | ||
10805355 | 22200 | 0 | None | 79 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 10 | 1 | 5 | 3.0 | O=[N+]([O-])c1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL132455 | 22200 | 0 | None | 79 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 316 | 10 | 1 | 5 | 3.0 | O=[N+]([O-])c1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
10519543 | 112998 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 317 | 3 | 0 | 3 | 4.1 | O=c1ccc2ccc(CN3CC=C(c4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL332001 | 112998 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 317 | 3 | 0 | 3 | 4.1 | O=c1ccc2ccc(CN3CC=C(c4ccccc4)CC3)cc2o1 | 10.1021/jm990266k | ||
155519378 | 169843 | 0 | None | 17 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 505 | 11 | 2 | 5 | 4.7 | COc1ccccc1N1CCN(CCCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4448166 | 169843 | 0 | None | 17 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 505 | 11 | 2 | 5 | 4.7 | COc1ccccc1N1CCN(CCCCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
25072632 | 111284 | 0 | None | -1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3ccc4ccnn4c3)CC2)c1Cl | 10.1021/jm5004039 | ||
CHEMBL3287392 | 111284 | 0 | None | -1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 4.6 | Clc1cccc(N2CCN(CCCCOc3ccc4ccnn4c3)CC2)c1Cl | 10.1021/jm5004039 | ||
18403576 | 6114 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1cc(Cl)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL108122 | 6114 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.3 | COc1cc(Cl)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
71294321 | 192184 | 0 | None | 512 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 351 | 5 | 0 | 5 | 2.0 | O=C1CCc2ccccc2N1CCCN1CCN(c2ncccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5172871 | 192184 | 0 | None | 512 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 351 | 5 | 0 | 5 | 2.0 | O=C1CCc2ccccc2N1CCCN1CCN(c2ncccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221357 | 192184 | 0 | None | 512 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 351 | 5 | 0 | 5 | 2.0 | O=C1CCc2ccccc2N1CCCN1CCN(c2ncccn2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
10593869 | 205300 | 0 | None | 60 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 3.8 | Cc1c(-c2ccccn2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL91553 | 205300 | 0 | None | 60 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 3.8 | Cc1c(-c2ccccn2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
10574303 | 205589 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 423 | 5 | 0 | 4 | 5.5 | Cc1c(-c2ccccc2)n(-c2ccccc2)c(=O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL93432 | 205589 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 423 | 5 | 0 | 4 | 5.5 | Cc1c(-c2ccccc2)n(-c2ccccc2)c(=O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
11451022 | 91724 | 0 | None | 10 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 4.6 | CCOc1ccccc1N1CCN(Cc2csc3ccccc23)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420890 | 91724 | 0 | None | 10 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 4.6 | CCOc1ccccc1N1CCN(Cc2csc3ccccc23)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
6603950 | 201633 | 9 | None | -13 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm020938y | ||
CHEMBL64875 | 201633 | 9 | None | -13 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm020938y | ||
3050372 | 69823 | 7 | None | 5 | 6 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 296 | 6 | 0 | 3 | 3.3 | c1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940414 | 69823 | 7 | None | 5 | 6 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 296 | 6 | 0 | 3 | 3.3 | c1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
127047996 | 139116 | 0 | None | 5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 303 | 8 | 3 | 5 | 2.3 | COc1ccccc1OCCNCCc1ccc(O)c(O)c1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3797758 | 139116 | 0 | None | 5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 303 | 8 | 3 | 5 | 2.3 | COc1ccccc1OCCNCCc1ccc(O)c(O)c1 | 10.1016/j.bmc.2016.04.028 | ||
71583848 | 87303 | 0 | None | 6 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 5.1 | c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
CHEMBL2336892 | 87303 | 0 | None | 6 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 5.1 | c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
11315028 | 110155 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 380 | 6 | 1 | 4 | 4.3 | COc1ccc(Cl)cc1NCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL325789 | 110155 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 380 | 6 | 1 | 4 | 4.3 | COc1ccc(Cl)cc1NCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
155529592 | 170881 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 509 | 10 | 2 | 5 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4463200 | 170881 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 509 | 10 | 2 | 5 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
71454294 | 83663 | 0 | None | 23 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 431 | 6 | 0 | 5 | 4.0 | COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207639 | 83663 | 0 | None | 23 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 431 | 6 | 0 | 5 | 4.0 | COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
44340084 | 9000 | 0 | None | 6 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 2 | 4 | 4.0 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL109912 | 9000 | 0 | None | 6 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 2 | 4 | 4.0 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
10549355 | 203792 | 0 | None | 234 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 406 | 5 | 1 | 4 | 5.1 | Cc1c(-c2ccc(Cl)cc2)nc(N)nc1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm970111h | ||
CHEMBL80722 | 203792 | 0 | None | 234 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 406 | 5 | 1 | 4 | 5.1 | Cc1c(-c2ccc(Cl)cc2)nc(N)nc1C1CCN(CCc2ccccc2)CC1 | 10.1021/jm970111h | ||
9948965 | 114870 | 0 | None | 74 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 283 | 9 | 1 | 2 | 4.0 | Cc1ccc(CCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL334989 | 114870 | 0 | None | 74 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 283 | 9 | 1 | 2 | 4.0 | Cc1ccc(CCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
137633863 | 156084 | 0 | None | -2 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4069145 | 156084 | 0 | None | -2 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
44459463 | 98702 | 0 | None | 19 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 331 | 4 | 1 | 2 | 4.8 | Cc1c(C2CCN(Cc3ccccc3)CC2)n[nH]c1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL281195 | 98702 | 0 | None | 19 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 331 | 4 | 1 | 2 | 4.8 | Cc1c(C2CCN(Cc3ccccc3)CC2)n[nH]c1-c1ccccc1 | 10.1016/s0960-894x(99)00169-9 | ||
10020040 | 99506 | 0 | None | 9 | 3 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 3.6 | CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL28651 | 99506 | 0 | None | 9 | 3 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 3.6 | CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
155528865 | 170823 | 0 | None | 1 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.0 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4462108 | 170823 | 0 | None | 1 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.0 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
155528865 | 170823 | 0 | None | 1 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.0 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4462108 | 170823 | 0 | None | 1 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 4.0 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
137660046 | 158796 | 0 | None | -6 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 7 | 2 | 8 | 2.4 | O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4100183 | 158796 | 0 | None | -6 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 7 | 2 | 8 | 2.4 | O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 | 10.1021/acs.jmedchem.7b00363 | ||
71734129 | 90630 | 0 | None | -11 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 9 | 1 | 3 | 5.2 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397480 | 90630 | 0 | None | -11 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 9 | 1 | 3 | 5.2 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm400520c | ||
1613 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00004a016 | ||
205 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00004a016 | ||
3964 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00004a016 | ||
CHEMBL831 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00004a016 | ||
DB00408 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00004a016 | ||
1613 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00043a008 | ||
205 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00043a008 | ||
3964 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00043a008 | ||
CHEMBL831 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00043a008 | ||
DB00408 | 2316 | 44 | None | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm00043a008 | ||
9839426 | 12044 | 0 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CCC(CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
CHEMBL1184179 | 12044 | 0 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CCC(CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
CHEMBL337228 | 12044 | 0 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CCC(CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
11153076 | 4888 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.4 | CCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL104801 | 4888 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.4 | CCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
137631542 | 155870 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 359 | 6 | 0 | 3 | 4.6 | CCOc1ccccc1CC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL4066603 | 155870 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 359 | 6 | 0 | 3 | 4.6 | CCOc1ccccc1CC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/acs.jmedchem.7b00151 | ||
72901200 | 119272 | 21 | None | 154 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
CHEMBL3480577 | 119272 | 21 | None | 154 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | nan | ||
3626837 | 205584 | 8 | None | -125 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm100925m | ||
CHEMBL93403 | 205584 | 8 | None | -125 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 2.9 | COc1cccc(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm100925m | ||
10862425 | 116133 | 0 | None | -9 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1 | 10.1021/jm025558r | ||
CHEMBL336930 | 116133 | 0 | None | -9 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1 | 10.1021/jm025558r | ||
44335678 | 4742 | 0 | None | 35 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 366 | 4 | 0 | 2 | 4.4 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccccc2F)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104155 | 4742 | 0 | None | 35 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 366 | 4 | 0 | 2 | 4.4 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccccc2F)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
21219166 | 99610 | 0 | None | 11 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 4.4 | c1ccc(CN2CCC(n3cnc(-c4ccccc4)c3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL287217 | 99610 | 0 | None | 11 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 317 | 4 | 0 | 3 | 4.4 | c1ccc(CN2CCC(n3cnc(-c4ccccc4)c3)CC2)cc1 | 10.1016/s0960-894x(99)00169-9 | ||
44436608 | 146223 | 0 | None | -47 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 7 | 1 | 3 | 4.3 | C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL392437 | 146223 | 0 | None | -47 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 7 | 1 | 3 | 4.3 | C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.bmc.2007.08.038 | ||
122181332 | 121359 | 0 | None | -8 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 432 | 9 | 1 | 3 | 5.6 | CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590083 | 121359 | 0 | None | -8 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 432 | 9 | 1 | 3 | 5.6 | CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | ||
56833464 | 68054 | 0 | None | -19 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1138 | 38 | 2 | 16 | 9.7 | CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1 | 10.1021/jm2009919 | ||
CHEMBL1916720 | 68054 | 0 | None | -19 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1138 | 38 | 2 | 16 | 9.7 | CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1 | 10.1021/jm2009919 | ||
11230330 | 134664 | 0 | None | -19 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 245 | 5 | 0 | 3 | 2.8 | CCCN(CCC)[C@H]1CCn2c(C#N)ccc2C1 | 10.1021/jm049269+ | ||
CHEMBL372020 | 134664 | 0 | None | -19 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 245 | 5 | 0 | 3 | 2.8 | CCCN(CCC)[C@H]1CCn2c(C#N)ccc2C1 | 10.1021/jm049269+ | ||
11417804 | 4765 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 7 | 0 | 5 | 3.9 | CCOc1cc(C#N)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104216 | 4765 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 7 | 0 | 5 | 3.9 | CCOc1cc(C#N)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
11750030 | 4785 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 402 | 5 | 0 | 4 | 4.8 | Clc1ccc(CN2CCOC(COc3ccc(Cl)c4cccnc34)C2)cc1 | 10.1021/jm031111m | ||
CHEMBL104307 | 4785 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 402 | 5 | 0 | 4 | 4.8 | Clc1ccc(CN2CCOC(COc3ccc(Cl)c4cccnc34)C2)cc1 | 10.1021/jm031111m | ||
11058829 | 168080 | 0 | None | 22 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 3 | 1 | 5 | 4.7 | Clc1ccc2c(c1)C(N1CCN(CCc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL436274 | 168080 | 0 | None | 22 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 3 | 1 | 5 | 4.7 | Clc1ccc2c(c1)C(N1CCN(CCc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
49798837 | 14229 | 0 | None | -16 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 433 | 3 | 1 | 3 | 4.5 | OC1(c2ccc(I)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1171249 | 14229 | 0 | None | -16 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 433 | 3 | 1 | 3 | 4.5 | OC1(c2ccc(I)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200077 | 14229 | 0 | None | -16 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 433 | 3 | 1 | 3 | 4.5 | OC1(c2ccc(I)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
10761258 | 100638 | 1 | None | 8 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL295094 | 100638 | 1 | None | 8 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2005.02.012 | ||
134130247 | 154038 | 0 | None | -2 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3890153 | 154038 | 0 | None | -2 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991291 | 154038 | 0 | None | -2 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 | 10.1016/j.bmc.2016.09.019 | ||
11036640 | 120634 | 0 | None | 12 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
CHEMBL357684 | 120634 | 0 | None | 12 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
10040546 | 204978 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | C[C@H]1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL89719 | 204978 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.0 | C[C@H]1c2ccccc2C=C(C2=CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
155552695 | 173472 | 0 | None | -22 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 268 | 3 | 0 | 3 | 2.7 | CCc1cc(Cl)c(OC)c(N2CCN(C)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4543685 | 173472 | 0 | None | -22 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 268 | 3 | 0 | 3 | 2.7 | CCc1cc(Cl)c(OC)c(N2CCN(C)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
11407122 | 167250 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 406 | 7 | 0 | 6 | 3.9 | COc1ccc([N+](=O)[O-])cc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL430658 | 167250 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 406 | 7 | 0 | 6 | 3.9 | COc1ccc([N+](=O)[O-])cc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
12050201 | 201185 | 0 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 5.3 | COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL62624 | 201185 | 0 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 5.3 | COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
42626318 | 55943 | 0 | None | -3090 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/ml500006v | ||
CHEMBL1627306 | 55943 | 0 | None | -3090 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/ml500006v | ||
71658205 | 89975 | 0 | None | -51 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 481 | 9 | 1 | 5 | 5.3 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(-c3ccc(F)cc3)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386619 | 89975 | 0 | None | -51 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 481 | 9 | 1 | 5 | 5.3 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(-c3ccc(F)cc3)s2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
44438234 | 93178 | 2 | None | -19 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246644 | 93178 | 2 | None | -19 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
16094681 | 82934 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(F)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
CHEMBL219261 | 82934 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 343 | 4 | 1 | 3 | 2.6 | Cc1cc(F)ccc1NC(=O)CN1CCC(c2cccc[n+]2[O-])CC1 | 10.1021/jm060662k | ||
164609172 | 183825 | 0 | None | -91 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 2.8 | O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4845947 | 183825 | 0 | None | -91 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 2.8 | O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
127051592 | 140347 | 0 | None | -18 | 7 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.4 | [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818710 | 140347 | 0 | None | -18 | 7 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.4 | [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819742 | 140347 | 0 | None | -18 | 7 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.4 | [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
56594534 | 70256 | 0 | None | -39 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO | 10.1021/jm200676f | ||
CHEMBL1949728 | 70256 | 0 | None | -39 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO | 10.1021/jm200676f | ||
11036640 | 120634 | 0 | None | 12 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
CHEMBL357684 | 120634 | 0 | None | 12 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
10761258 | 100638 | 1 | None | 8 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1cccc(Cl)c1 | 10.1021/jm970021c | ||
CHEMBL295094 | 100638 | 1 | None | 8 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1cccc(Cl)c1 | 10.1021/jm970021c | ||
134130247 | 154038 | 0 | None | -2 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3890153 | 154038 | 0 | None | -2 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991291 | 154038 | 0 | None | -2 | 8 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 4.3 | c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2 | 10.1016/j.bmc.2016.09.019 | ||
25070742 | 111290 | 0 | None | -2 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2cccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c12 | 10.1021/jm5004039 | ||
CHEMBL3287398 | 111290 | 0 | None | -2 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2cccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c12 | 10.1021/jm5004039 | ||
118709178 | 112849 | 0 | None | -23 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1154 | 32 | 0 | 17 | 9.5 | O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3317465 | 112849 | 0 | None | -23 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1154 | 32 | 0 | 17 | 9.5 | O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
118709161 | 112908 | 0 | None | -15 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 860 | 19 | 0 | 8 | 10.5 | O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318833 | 112908 | 0 | None | -15 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 860 | 19 | 0 | 8 | 10.5 | O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
137657322 | 159096 | 0 | None | -53 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 461 | 8 | 2 | 8 | 2.7 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4103639 | 159096 | 0 | None | -53 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 461 | 8 | 2 | 8 | 2.7 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
164622487 | 185540 | 0 | None | -3 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 339 | 4 | 0 | 4 | 2.8 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4871850 | 185540 | 0 | None | -3 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 339 | 4 | 0 | 4 | 2.8 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
11584858 | 82360 | 0 | None | -25 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 554 | 11 | 1 | 7 | 4.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1 | 10.1021/jm0611152 | ||
CHEMBL217981 | 82360 | 0 | None | -25 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 554 | 11 | 1 | 7 | 4.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1 | 10.1021/jm0611152 | ||
155562395 | 175375 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4587925 | 175375 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
11545813 | 180612 | 0 | None | 4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL476109 | 180612 | 0 | None | 4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
10617946 | 203807 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 351 | 4 | 1 | 2 | 5.1 | Clc1ccc(-c2cc(C3CCCN(Cc4ccccc4)C3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL80833 | 203807 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 351 | 4 | 1 | 2 | 5.1 | Clc1ccc(-c2cc(C3CCCN(Cc4ccccc4)C3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10805797 | 112407 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 322 | 7 | 1 | 4 | 3.7 | CCN(CCNc1ccccc1)Cc1ccc2ccc(=O)oc2c1 | 10.1021/jm990266k | ||
CHEMBL331045 | 112407 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 322 | 7 | 1 | 4 | 3.7 | CCN(CCNc1ccccc1)Cc1ccc2ccc(=O)oc2c1 | 10.1021/jm990266k | ||
145979855 | 165975 | 0 | None | -18 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 7 | 2 | 5 | 3.5 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4279136 | 165975 | 0 | None | -18 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 7 | 2 | 5 | 3.5 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
44319102 | 204421 | 0 | None | 2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 321 | 4 | 0 | 4 | 2.7 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL86060 | 204421 | 0 | None | 2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 321 | 4 | 0 | 4 | 2.7 | c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
20354789 | 114026 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 281 | 5 | 0 | 2 | 3.5 | c1ccc(CCC2CN(Cc3ccccc3)CCO2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335544 | 114026 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 281 | 5 | 0 | 2 | 3.5 | c1ccc(CCC2CN(Cc3ccccc3)CCO2)cc1 | 10.1021/ml500267c | ||
142590702 | 179216 | 0 | None | -1 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 8 | 1 | 3 | 5.7 | O=C(c1ccccc1)N1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4744824 | 179216 | 0 | None | -1 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 466 | 8 | 1 | 3 | 5.7 | O=C(c1ccccc1)N1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
22727346 | 13054 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 435 | 9 | 0 | 6 | 4.8 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4C)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1190866 | 13054 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 435 | 9 | 0 | 6 | 4.8 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4C)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL541791 | 13054 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 435 | 9 | 0 | 6 | 4.8 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4C)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
10597050 | 108709 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 398 | 6 | 0 | 3 | 5.4 | COc1cccc2c1CCCC2CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm991138z | ||
CHEMBL321557 | 108709 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 398 | 6 | 0 | 3 | 5.4 | COc1cccc2c1CCCC2CCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm991138z | ||
44393372 | 65994 | 0 | None | -48 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 549 | 8 | 1 | 5 | 4.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL184993 | 65994 | 0 | None | -48 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 549 | 8 | 1 | 5 | 4.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1 | 10.1016/j.bmcl.2004.05.052 | ||
127053198 | 138842 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 317 | 5 | 0 | 3 | 3.6 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793112 | 138842 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 317 | 5 | 0 | 3 | 3.6 | Clc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
127029390 | 138953 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794421 | 138953 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(OC[C@@H]2CN(Cc3ccc(Cl)cc3)CCO2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
56964794 | 73716 | 0 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 418 | 3 | 0 | 5 | 4.8 | Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2 | 10.1021/jm2013419 | ||
CHEMBL2022272 | 73716 | 0 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 418 | 3 | 0 | 5 | 4.8 | Clc1ccc2c(c1)N=C(N1CCN(CCc3ccccc3)CC1)c1cccnc1O2 | 10.1021/jm2013419 | ||
122189393 | 122732 | 0 | None | -7 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 455 | 6 | 0 | 7 | 4.0 | Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613879 | 122732 | 0 | None | -7 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 455 | 6 | 0 | 7 | 4.0 | Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.07.050 | ||
46917563 | 67993 | 0 | None | -58 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 561 | 18 | 1 | 7 | 5.5 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1 | 10.1021/jm2009919 | ||
CHEMBL1916551 | 67993 | 0 | None | -58 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 561 | 18 | 1 | 7 | 5.5 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1 | 10.1021/jm2009919 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00179-8 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00179-8 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00179-8 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00179-8 | ||
10761912 | 111825 | 0 | None | 6 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 3.5 | COc1cccc(NC(=O)CCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL329228 | 111825 | 0 | None | 6 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 6 | 1 | 4 | 3.5 | COc1cccc(NC(=O)CCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
10810976 | 206186 | 0 | None | 10 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 399 | 5 | 0 | 4 | 3.2 | COc1cccc2c1CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2=O | 10.1021/jm991138z | ||
CHEMBL96799 | 206186 | 0 | None | 10 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 399 | 5 | 0 | 4 | 3.2 | COc1cccc2c1CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2=O | 10.1021/jm991138z | ||
9928335 | 119592 | 1 | None | -1 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL35093 | 119592 | 1 | None | -1 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
10520781 | 205257 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 2 | 0 | 4 | 3.0 | COc1ccc2c3c(c(=O)oc2c1)CN(C(=O)c1ccccc1)CC3 | 10.1021/jm970170v | ||
CHEMBL91367 | 205257 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 2 | 0 | 4 | 3.0 | COc1ccc2c3c(c(=O)oc2c1)CN(C(=O)c1ccccc1)CC3 | 10.1021/jm970170v | ||
16103 | 202932 | 37 | None | -5 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 292 | 0 | 1 | 4 | 3.1 | CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
CHEMBL73538 | 202932 | 37 | None | -5 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 292 | 0 | 1 | 4 | 3.1 | CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1 | 10.1021/jm00043a008 | ||
1438298 | 38383 | 4 | None | 26 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 328 | 5 | 1 | 3 | 2.9 | Cc1ccc(C(=O)C2CCN(CC(=O)NC3CCCC3)CC2)cc1 | 10.1021/acs.jmedchem.9b01560 | ||
CHEMBL1465169 | 38383 | 4 | None | 26 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 328 | 5 | 1 | 3 | 2.9 | Cc1ccc(C(=O)C2CCN(CC(=O)NC3CCCC3)CC2)cc1 | 10.1021/acs.jmedchem.9b01560 | ||
44381146 | 58199 | 0 | None | 1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 429 | 7 | 1 | 4 | 3.6 | COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL168372 | 58199 | 0 | None | 1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 429 | 7 | 1 | 4 | 3.6 | COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL5087504 | 213330 | 0 | None | -1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | Oc1cccc(C(CCNCCCCN2CCN(c3ccccc3)CC2)c2cccc(O)c2)c1 | 10.1021/acs.jmedchem.1c00611 | ||||
17755868 | 142586 | 1 | None | -5 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 0 | 1 | 2 | 3.8 | CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1 | 10.1021/jm070388+ | ||
CHEMBL389559 | 142586 | 1 | None | -5 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 0 | 1 | 2 | 3.8 | CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1 | 10.1021/jm070388+ | ||
44330650 | 106918 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 212 | 0 | 1 | 1 | 3.2 | Cc1ccc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL317988 | 106918 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 212 | 0 | 1 | 1 | 3.2 | Cc1ccc(C)c2c1CCCc1c[nH]nc1-2 | 10.1016/s0960-894x(03)00587-0 | ||
11676873 | 9105 | 0 | None | -1071 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 455 | 8 | 1 | 4 | 4.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1 | 10.1021/jm0704200 | ||
CHEMBL110365 | 9105 | 0 | None | -1071 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 455 | 8 | 1 | 4 | 4.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1 | 10.1021/jm0704200 | ||
122180612 | 121226 | 0 | None | -72 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 467 | 9 | 0 | 6 | 5.2 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588983 | 121226 | 0 | None | -72 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 467 | 9 | 0 | 6 | 5.2 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
17755991 | 151766 | 0 | None | -14 | 5 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 267 | 0 | 2 | 2 | 3.1 | Oc1ccc2c(c1)CCCNCCc1ccccc1C2 | 10.1021/jm070388+ | ||
CHEMBL396950 | 151766 | 0 | None | -14 | 5 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 267 | 0 | 2 | 2 | 3.1 | Oc1ccc2c(c1)CCCNCCc1ccccc1C2 | 10.1021/jm070388+ | ||
CHEMBL5073904 | 212536 | 0 | None | -6 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | N#CC(CCNCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
16744004 | 91896 | 0 | None | -204 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 10 | 0 | 6 | 5.7 | COc1ccc(C2=NO[C@H](CCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)C2)cc1OC | 10.1016/j.ejmech.2006.12.030 | ||
CHEMBL243012 | 91896 | 0 | None | -204 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 10 | 0 | 6 | 5.7 | COc1ccc(C2=NO[C@H](CCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)C2)cc1OC | 10.1016/j.ejmech.2006.12.030 | ||
72191068 | 91923 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 458 | 9 | 0 | 8 | 4.2 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(-c4cnco4)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
CHEMBL2430438 | 91923 | 0 | None | -3 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 458 | 9 | 0 | 8 | 4.2 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(-c4cnco4)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
168270563 | 189357 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5170381 | 189357 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 4.0 | Fc1ccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
9843137 | 4759 | 0 | None | 6 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 4 | 0 | 4 | 2.9 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCOc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104196 | 4759 | 0 | None | 6 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 4 | 0 | 4 | 2.9 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCOc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
71657944 | 89963 | 0 | None | -77 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386607 | 89963 | 0 | None | -77 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
49783209 | 17427 | 0 | None | -74 | 27 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
CHEMBL1258223 | 17427 | 0 | None | -74 | 27 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
44335996 | 4856 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL104678 | 4856 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
9796180 | 112372 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 1 | 4 | 3.0 | O=c1ccc2ccc(CNCCOc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL330966 | 112372 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 6 | 1 | 4 | 3.0 | O=c1ccc2ccc(CNCCOc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
93601125 | 138821 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1OC | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792941 | 138821 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 343 | 7 | 0 | 5 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1OC | 10.1016/j.bmcl.2016.03.102 | ||
44276170 | 95870 | 0 | None | -12 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 9 | 0 | 5 | 3.9 | COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL26135 | 95870 | 0 | None | -12 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 9 | 0 | 5 | 3.9 | COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1016/S0960-894X(97)00218-7 | ||
10001519 | 98852 | 0 | None | -8 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 408 | 8 | 0 | 4 | 5.1 | COc1ccccc1N1CCN(CCCCC2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL28209 | 98852 | 0 | None | -8 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 408 | 8 | 0 | 4 | 5.1 | COc1ccccc1N1CCN(CCCCC2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
44431463 | 87642 | 2 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2ccc(Cl)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234641 | 87642 | 2 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2ccc(Cl)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
11761412 | 116451 | 0 | None | -89 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 411 | 9 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.09.142 | ||
CHEMBL338606 | 116451 | 0 | None | -89 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 411 | 9 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.09.142 | ||
72737744 | 114020 | 0 | None | 64 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335538 | 114020 | 0 | None | 64 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
44408818 | 139635 | 1 | None | -21 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL380330 | 139635 | 1 | None | -21 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1016/j.bmc.2009.08.028 | ||
164621388 | 185154 | 0 | None | -7 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 0 | 3 | 3.7 | Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4866058 | 185154 | 0 | None | -7 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 0 | 3 | 3.7 | Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 | 10.1016/j.ejmech.2021.113243 | ||
11328099 | 4781 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 6 | 0 | 4 | 3.6 | COc1cc(I)ccc1OCC1CN(Cc2ccccc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104291 | 4781 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 439 | 6 | 0 | 4 | 3.6 | COc1cc(I)ccc1OCC1CN(Cc2ccccc2)CCO1 | 10.1021/jm031111m | ||
9826801 | 107451 | 0 | None | -18620 | 12 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL319352 | 107451 | 0 | None | -18620 | 12 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
57390694 | 70122 | 0 | None | -1 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 5.1 | Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946255 | 70122 | 0 | None | -1 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 5.1 | Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
57390694 | 70122 | 0 | None | -1 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 5.1 | Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL1946255 | 70122 | 0 | None | -1 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 5.1 | Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.ejmech.2012.03.042 | ||
57403981 | 70151 | 0 | None | -33 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946745 | 70151 | 0 | None | -33 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
76524414 | 140338 | 0 | None | -33 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819434 | 140338 | 0 | None | -33 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819713 | 140338 | 0 | None | -33 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
44330639 | 206434 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 219 | 0 | 0 | 4 | 2.4 | Cc1sc(C)c2c1CCCc1nncn1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL98331 | 206434 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 219 | 0 | 0 | 4 | 2.4 | Cc1sc(C)c2c1CCCc1nncn1-2 | 10.1016/s0960-894x(03)00587-0 | ||
11488247 | 198955 | 0 | None | -7244 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 4.5 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | ||
CHEMBL599487 | 198955 | 0 | None | -7244 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 4.5 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | ||
71062664 | 146328 | 0 | None | - | 1 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 353 | 6 | 0 | 5 | 2.5 | Cc1ncccc1OC[C@@H]1CN(CCN2CCc3ccccc32)CCO1 | nan | ||
CHEMBL3925231 | 146328 | 0 | None | - | 1 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 353 | 6 | 0 | 5 | 2.5 | Cc1ncccc1OC[C@@H]1CN(CCN2CCc3ccccc32)CCO1 | nan | ||
76524414 | 140338 | 0 | None | -33 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819434 | 140338 | 0 | None | -33 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819713 | 140338 | 0 | None | -33 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
46231849 | 199733 | 0 | None | -2754 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 1 | 2 | 4 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL604732 | 199733 | 0 | None | -2754 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 1 | 2 | 4 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
9950913 | 102279 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 363 | 3 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(C3CCc4ccccc4N(C)C3=O)CC2)cc1 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL305061 | 102279 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 363 | 3 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(C3CCc4ccccc4N(C)C3=O)CC2)cc1 | 10.1016/s0960-894x(00)00421-2 | ||
11794570 | 197068 | 0 | None | 3 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)on3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL58296 | 197068 | 0 | None | 3 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)on3)CC2)cc1 | 10.1021/jm970111h | ||
10884046 | 164817 | 0 | None | -3 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
CHEMBL423735 | 164817 | 0 | None | -3 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
44403213 | 71443 | 4 | None | -83 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 7 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL196744 | 71443 | 4 | None | -83 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 7 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2005.07.037 | ||
155531809 | 171091 | 0 | None | 11 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 555 | 8 | 2 | 4 | 4.3 | O=C(NCCN1CCN(c2ccc(I)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4466114 | 171091 | 0 | None | 11 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 555 | 8 | 2 | 4 | 4.3 | O=C(NCCN1CCN(c2ccc(I)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
162648426 | 179380 | 0 | None | 2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 6 | 0 | 3 | 4.6 | Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4746695 | 179380 | 0 | None | 2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 6 | 0 | 3 | 4.6 | Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1 | 10.1016/j.bmc.2020.115943 | ||
127053215 | 138894 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 313 | 6 | 0 | 4 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793858 | 138894 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 313 | 6 | 0 | 4 | 3.0 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
164621388 | 185154 | 0 | None | -7 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 0 | 3 | 3.7 | Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4866058 | 185154 | 0 | None | -7 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 0 | 3 | 3.7 | Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2 | 10.1016/j.ejmech.2021.113243 | ||
44431466 | 87643 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2ccc(Br)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234643 | 87643 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2ccc(Br)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
3038495 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm060138d | ||
7625 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm060138d | ||
CHEMBL25236 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm060138d | ||
11794570 | 197068 | 0 | None | 3 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)on3)CC2)cc1 | 10.1021/jm960072u | ||
CHEMBL58296 | 197068 | 0 | None | 3 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 4 | 0 | 3 | 6.0 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)on3)CC2)cc1 | 10.1021/jm960072u | ||
1248739 | 139556 | 16 | None | 19 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 310 | 3 | 0 | 4 | 2.8 | Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL380054 | 139556 | 16 | None | 19 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 310 | 3 | 0 | 4 | 2.8 | Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
22100962 | 202564 | 0 | None | 40 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1ccc2sc(C3=CCN(Cc4ccccc4)CC3)nc2c1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL71209 | 202564 | 0 | None | 40 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1ccc2sc(C3=CCN(Cc4ccccc4)CC3)nc2c1 | 10.1016/S0960-894X(97)00402-2 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm8007618 | ||
3038495 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm050170s | ||
7625 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm050170s | ||
CHEMBL25236 | 700 | 30 | None | -91 | 19 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm050170s | ||
60165541 | 74996 | 0 | None | 1 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.1 | O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037518 | 74996 | 0 | None | 1 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.1 | O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
44329749 | 112107 | 0 | None | -28 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 265 | 2 | 1 | 4 | 2.7 | CCCN1CCOC2c3cc(O)ccc3SCC21 | 10.1021/jm0000113 | ||
CHEMBL330216 | 112107 | 0 | None | -28 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 265 | 2 | 1 | 4 | 2.7 | CCCN1CCOC2c3cc(O)ccc3SCC21 | 10.1021/jm0000113 | ||
164609650 | 184414 | 0 | None | -1 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 389 | 4 | 0 | 4 | 4.0 | O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4854456 | 184414 | 0 | None | -1 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 389 | 4 | 0 | 4 | 4.0 | O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
10003809 | 82752 | 0 | None | -97 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 448 | 8 | 1 | 6 | 4.1 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3s2)CC1 | 10.1021/jm0611152 | ||
CHEMBL218318 | 82752 | 0 | None | -97 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 448 | 8 | 1 | 6 | 4.1 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3s2)CC1 | 10.1021/jm0611152 | ||
137653986 | 158184 | 0 | None | -2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 249 | 1 | 3 | 5 | 0.1 | O=C1COc2c(N3CCNCC3)ccc(O)c2N1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4093493 | 158184 | 0 | None | -2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 249 | 1 | 3 | 5 | 0.1 | O=C1COc2c(N3CCNCC3)ccc(O)c2N1 | 10.1016/j.bmc.2017.08.037 | ||
44319369 | 204105 | 0 | None | 2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 3.0 | C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL83306 | 204105 | 0 | None | 2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 3.0 | C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1 | 10.1016/s0960-894x(01)00484-x | ||
168292271 | 191292 | 0 | None | 5 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 424 | 6 | 1 | 3 | 5.1 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(Cl)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5199815 | 191292 | 0 | None | 5 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 424 | 6 | 1 | 3 | 5.1 | Cc1c(Cl)cccc1NC(=O)CN1CCC(OCc2ccc(Cl)c(F)c2)CC1 | 10.1016/j.bmcl.2022.128615 | ||
44381432 | 120206 | 0 | None | -1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.6 | c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL354748 | 120206 | 0 | None | -1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 334 | 3 | 1 | 4 | 2.6 | c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1 | 10.1016/s0960-894x(03)00004-0 | ||
71658208 | 89978 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 441 | 10 | 1 | 6 | 3.4 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cccc(OC)c2OC)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386622 | 89978 | 0 | None | -10 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 441 | 10 | 1 | 6 | 3.4 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cccc(OC)c2OC)CC1 | 10.1016/j.bmc.2013.03.074 | ||
134141355 | 154048 | 0 | None | -3 | 9 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.8 | O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3924565 | 154048 | 0 | None | -3 | 9 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.8 | O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991357 | 154048 | 0 | None | -3 | 9 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.8 | O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
44582675 | 189109 | 0 | None | -7 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
CHEMBL515472 | 189109 | 0 | None | -7 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
76318477 | 105808 | 0 | None | -2454 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(O)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3133875 | 105808 | 0 | None | -2454 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(O)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3139049 | 105808 | 0 | None | -2454 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 3.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(O)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
44438226 | 154125 | 0 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 395 | 5 | 2 | 2 | 4.5 | CC(=O)NCC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL399601 | 154125 | 0 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 395 | 5 | 2 | 2 | 4.5 | CC(=O)NCC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
122180573 | 121211 | 0 | None | -891 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 517 | 7 | 0 | 5 | 6.3 | Clc1cccc(N2CCN(CCCCc3cn(-c4ccc5c(c4)Cc4ccccc4-5)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588918 | 121211 | 0 | None | -891 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 517 | 7 | 0 | 5 | 6.3 | Clc1cccc(N2CCN(CCCCc3cn(-c4ccc5c(c4)Cc4ccccc4-5)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.01.017 | ||
134141355 | 154048 | 0 | None | -3 | 9 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.8 | O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3924565 | 154048 | 0 | None | -3 | 9 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.8 | O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991357 | 154048 | 0 | None | -3 | 9 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.8 | O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
168295019 | 191901 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5209079 | 191901 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 357 | 5 | 0 | 4 | 3.8 | Fc1ccc(CO[C@H]2CCCN(Cc3ncn4ccccc34)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
44396220 | 124903 | 1 | None | -177 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 295 | 6 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 | 10.1021/jm049720x | ||
CHEMBL364565 | 124903 | 1 | None | -177 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 295 | 6 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 | 10.1021/jm049720x | ||
133633 | 2210 | 46 | None | -104 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2010.05.052 | ||
177 | 2210 | 46 | None | -104 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL445102 | 2210 | 46 | None | -104 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2010.05.052 | ||
44278496 | 99088 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 389 | 8 | 0 | 3 | 5.2 | COC(COc1cccc2ccccc12)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL28355 | 99088 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 389 | 8 | 0 | 3 | 5.2 | COC(COc1cccc2ccccc12)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
44278624 | 99880 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 3 | 5.2 | OC(COc1cccc2ccccc12)CN1CCC(Cc2ccc(Cl)cc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL28953 | 99880 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 3 | 5.2 | OC(COc1cccc2ccccc12)CN1CCC(Cc2ccc(Cl)cc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
52943802 | 17436 | 0 | None | 7 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 6 | 0 | 2 | 5.8 | Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1258270 | 17436 | 0 | None | 7 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 6 | 0 | 2 | 5.8 | Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1 | 10.1021/jm100899z | ||
57395341 | 68969 | 0 | None | -2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 495 | 13 | 1 | 8 | 2.8 | CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928135 | 68969 | 0 | None | -2 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 495 | 13 | 1 | 8 | 2.8 | CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
71583849 | 87304 | 0 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 5.1 | c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
CHEMBL2336893 | 87304 | 0 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 5.1 | c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1 | 10.1016/j.bmc.2013.01.065 | ||
164609650 | 184414 | 0 | None | -1 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 4 | 0 | 4 | 4.0 | O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4854456 | 184414 | 0 | None | -1 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 4 | 0 | 4 | 4.0 | O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
6937303 | 201517 | 6 | None | 3 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 4.1 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64376 | 201517 | 6 | None | 3 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 4.1 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
44264742 | 96726 | 0 | None | 1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 298 | 3 | 0 | 4 | 2.8 | c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL268190 | 96726 | 0 | None | 1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 298 | 3 | 0 | 4 | 2.8 | c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1 | 10.1016/s0960-894x(98)00692-1 | ||
75201901 | 165872 | 14 | None | -331 | 24 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
CHEMBL4277264 | 165872 | 14 | None | -331 | 24 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
42626380 | 55950 | 0 | None | -125 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 548 | 8 | 3 | 5 | 3.1 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3[nH]2)CC1 | 10.1021/jm900095y | ||
CHEMBL1627313 | 55950 | 0 | None | -125 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 548 | 8 | 3 | 5 | 3.1 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3[nH]2)CC1 | 10.1021/jm900095y | ||
3191 | 102385 | 93 | None | -10 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
CHEMBL305660 | 102385 | 93 | None | -10 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
145986752 | 166723 | 0 | None | -1 | 17 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 562 | 10 | 1 | 5 | 7.3 | COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL4293307 | 166723 | 0 | None | -1 | 17 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 562 | 10 | 1 | 5 | 7.3 | COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 | 10.1016/j.bmcl.2018.10.036 | ||
44393403 | 64747 | 0 | None | -125 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 533 | 8 | 1 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL182379 | 64747 | 0 | None | -125 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 533 | 8 | 1 | 5 | 4.4 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1 | 10.1016/j.bmcl.2004.05.052 | ||
10432808 | 58441 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL168611 | 58441 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
10001207 | 164769 | 0 | None | 38 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 3.7 | COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL423440 | 164769 | 0 | None | 38 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 3.7 | COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
155514137 | 169261 | 0 | None | 15 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 539 | 9 | 2 | 4 | 5.0 | O=C(NCCCN1CCN(c2ccc(Br)cc2)CC1)NN(Cc1ccc(F)cc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4439728 | 169261 | 0 | None | 15 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 539 | 9 | 2 | 4 | 5.0 | O=C(NCCCN1CCN(c2ccc(Br)cc2)CC1)NN(Cc1ccc(F)cc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
118709179 | 112927 | 0 | None | -18 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1198 | 35 | 0 | 18 | 9.5 | O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318851 | 112927 | 0 | None | -18 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1198 | 35 | 0 | 18 | 9.5 | O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
44222488 | 194552 | 0 | None | 4 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 382 | 7 | 0 | 4 | 4.5 | Clc1ccc(N2CCN(CCCCCc3cc4ccccn4n3)CC2)cc1 | 10.1021/jm900690y | ||
CHEMBL561622 | 194552 | 0 | None | 4 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 382 | 7 | 0 | 4 | 4.5 | Clc1ccc(N2CCN(CCCCCc3cc4ccccn4n3)CC2)cc1 | 10.1021/jm900690y | ||
11303390 | 4818 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104476 | 4818 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.4 | CC(C)Oc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
8592415 | 64838 | 7 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1cccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL182432 | 64838 | 7 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1cccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
10763496 | 111107 | 0 | None | 5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.1 | COc1ccc2c(c1)C(NCCN1CCN(c3ccc(Cl)cc3)CC1)CCC2 | 10.1021/jm991138z | ||
CHEMBL328283 | 111107 | 0 | None | 5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.1 | COc1ccc2c(c1)C(NCCN1CCN(c3ccc(Cl)cc3)CC1)CCC2 | 10.1021/jm991138z | ||
135471592 | 121168 | 0 | None | 3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 397 | 3 | 2 | 5 | 4.8 | Cc1ccc2c(c1)C(NC1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL358657 | 121168 | 0 | None | 3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 397 | 3 | 2 | 5 | 4.8 | Cc1ccc2c(c1)C(NC1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
72737728 | 114021 | 0 | None | 60 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 311 | 6 | 0 | 3 | 3.5 | COc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335539 | 114021 | 0 | None | 60 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 311 | 6 | 0 | 3 | 3.5 | COc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
127051592 | 140347 | 0 | None | -18 | 7 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.4 | [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818710 | 140347 | 0 | None | -18 | 7 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.4 | [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819742 | 140347 | 0 | None | -18 | 7 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 317 | 5 | 0 | 2 | 3.4 | [O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
42606339 | 17749 | 0 | None | 19 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 397 | 5 | 1 | 4 | 4.3 | Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1 | 10.1021/jm100835q | ||
CHEMBL1259241 | 17749 | 0 | None | 19 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 397 | 5 | 1 | 4 | 4.3 | Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1 | 10.1021/jm100835q | ||
44381279 | 58431 | 0 | None | 10 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 2.1 | O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
CHEMBL168571 | 58431 | 0 | None | 10 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 2.1 | O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1 | 10.1016/s0960-894x(03)00004-0 | ||
44330638 | 106793 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 233 | 0 | 0 | 4 | 2.7 | Cc1sc(C)c2c1CCCc1nnc(C)n1-2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL317051 | 106793 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 233 | 0 | 0 | 4 | 2.7 | Cc1sc(C)c2c1CCCc1nnc(C)n1-2 | 10.1016/s0960-894x(03)00587-0 | ||
44335722 | 108389 | 0 | None | 7 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1cccc2c1CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL321058 | 108389 | 0 | None | 7 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1cccc2c1CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44427827 | 92843 | 0 | None | -1548 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 498 | 8 | 2 | 5 | 4.4 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1 | 10.1021/jm0704200 | ||
CHEMBL244990 | 92843 | 0 | None | -1548 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 498 | 8 | 2 | 5 | 4.4 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1 | 10.1021/jm0704200 | ||
44276105 | 13343 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 381 | 7 | 0 | 5 | 4.9 | Cc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1193100 | 13343 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 381 | 7 | 0 | 5 | 4.9 | Cc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL544451 | 13343 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 381 | 7 | 0 | 5 | 4.9 | Cc1ccccc1N1CCN(CCCCc2cc(-c3cccs3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL5093200 | 213641 | 0 | None | -39 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | CN(C)CCC(C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
10546828 | 203715 | 0 | None | 5 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 365 | 4 | 1 | 2 | 5.3 | CC1(c2cc(-c3ccc(Cl)cc3)[nH]n2)CCN(Cc2ccccc2)CC1 | 10.1021/jm970111h | ||
CHEMBL80207 | 203715 | 0 | None | 5 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 365 | 4 | 1 | 2 | 5.3 | CC1(c2cc(-c3ccc(Cl)cc3)[nH]n2)CCN(Cc2ccccc2)CC1 | 10.1021/jm970111h | ||
44323762 | 204851 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(CN2CCN(c3cccc4[nH]cnc34)CC2)cc1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL88837 | 204851 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(CN2CCN(c3cccc4[nH]cnc34)CC2)cc1 | 10.1016/s0960-894x(98)00474-0 | ||
44323851 | 205246 | 0 | None | -10 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 302 | 1 | 0 | 2 | 3.8 | C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL91310 | 205246 | 0 | None | -10 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 302 | 1 | 0 | 2 | 3.8 | C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
76309672 | 85461 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 3 | 1 | 1 | 2.2 | c1ccc(C[n+]2cc[n+](-c3cccc4[nH]cnc34)cc2)cc1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL2298811 | 85461 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 3 | 1 | 1 | 2.2 | c1ccc(C[n+]2cc[n+](-c3cccc4[nH]cnc34)cc2)cc1 | 10.1007/s00044-012-0055-5 | ||
45482151 | 196332 | 0 | None | -9 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 451 | 8 | 1 | 9 | 1.7 | COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1 | 10.1016/j.bmc.2009.06.041 | ||
CHEMBL573791 | 196332 | 0 | None | -9 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 451 | 8 | 1 | 9 | 1.7 | COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1 | 10.1016/j.bmc.2009.06.041 | ||
9843031 | 109576 | 0 | None | 56 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL323537 | 109576 | 0 | None | 56 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
44380815 | 58701 | 0 | None | 2 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL169193 | 58701 | 0 | None | 2 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.9 | CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl | 10.1016/s0960-894x(99)00086-4 | ||
11299620 | 96835 | 2 | None | -87 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@H]1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
CHEMBL269004 | 96835 | 2 | None | -87 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 247 | 5 | 1 | 2 | 3.4 | CCCN(CCC)[C@H]1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
127032086 | 138792 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 337 | 5 | 0 | 5 | 2.9 | Cn1ncc2cc(CN3CCO[C@H](COc4ccccc4)C3)ccc21 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792637 | 138792 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 337 | 5 | 0 | 5 | 2.9 | Cn1ncc2cc(CN3CCO[C@H](COc4ccccc4)C3)ccc21 | 10.1016/j.bmcl.2016.03.102 | ||
127030606 | 138832 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793033 | 138832 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
90644226 | 111287 | 0 | None | -22 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 490 | 9 | 0 | 7 | 4.8 | CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
CHEMBL3287395 | 111287 | 0 | None | -22 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 490 | 9 | 0 | 7 | 4.8 | CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
122181328 | 121355 | 0 | None | -33 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590079 | 121355 | 0 | None | -33 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 4.5 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmc.2014.12.012 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00108-5 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00108-5 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00108-5 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(98)00108-5 | ||
11033734 | 9629 | 1 | None | -120 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 3.1 | COc1cccc2c1N1CCN(C)C[C@H]1c1ccccc1C2 | 10.1021/jm010566d | ||
CHEMBL113238 | 9629 | 1 | None | -120 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 3.1 | COc1cccc2c1N1CCN(C)C[C@H]1c1ccccc1C2 | 10.1021/jm010566d | ||
164609529 | 183882 | 0 | None | -64 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 5 | 0 | 4 | 4.1 | CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4846823 | 183882 | 0 | None | -64 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 5 | 0 | 4 | 4.1 | CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
76336022 | 105898 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115581 | 105898 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139316 | 105898 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | ||
11304676 | 102333 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 418 | 6 | 1 | 4 | 3.3 | COc1cc(Br)cc(C(=O)NCCN2CCc3ccccc3C2)c1OC | 10.1016/j.bmcl.2003.09.083 | ||
CHEMBL305366 | 102333 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 418 | 6 | 1 | 4 | 3.3 | COc1cc(Br)cc(C(=O)NCCN2CCc3ccccc3C2)c1OC | 10.1016/j.bmcl.2003.09.083 | ||
10587140 | 203325 | 1 | None | 1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 3.1 | Cc1cc(C2CCN(Cc3ccccc3)CC2)[nH]n1 | 10.1021/jm970111h | ||
CHEMBL77015 | 203325 | 1 | None | 1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 3.1 | Cc1cc(C2CCN(Cc3ccccc3)CC2)[nH]n1 | 10.1021/jm970111h | ||
137643132 | 157506 | 0 | None | -3890 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 503 | 7 | 1 | 7 | 3.8 | CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1 | 10.1016/j.bmc.2017.04.036 | ||
CHEMBL4085920 | 157506 | 0 | None | -3890 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 503 | 7 | 1 | 7 | 3.8 | CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1 | 10.1016/j.bmc.2017.04.036 | ||
164609172 | 183825 | 0 | None | -91 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 2.8 | O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4845947 | 183825 | 0 | None | -91 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 2.8 | O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
10454026 | 17725 | 0 | None | -1479 | 9 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 3.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm900095y | ||
CHEMBL125916 | 17725 | 0 | None | -1479 | 9 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 3.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1 | 10.1021/jm900095y | ||
168275515 | 189911 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.1 | Cc1nc(CN2CCC(OCc3ccc(F)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5179340 | 189911 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 371 | 5 | 0 | 4 | 4.1 | Cc1nc(CN2CCC(OCc3ccc(F)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
621 | 906 | 64 | None | -8 | 72 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
83 | 906 | 64 | None | -8 | 72 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
9886340 | 5342 | 0 | None | 97 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1cccc2c1N(C(=O)CN1CCN(Cc3ccc(Cl)cc3)CC1)CC2 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107229 | 5342 | 0 | None | 97 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1cccc2c1N(C(=O)CN1CCN(Cc3ccc(Cl)cc3)CC1)CC2 | 10.1016/s0960-894x(02)00655-8 | ||
44380816 | 119845 | 0 | None | 22 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 3.7 | COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL353090 | 119845 | 0 | None | 22 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 3.7 | COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
6604756 | 98375 | 12 | None | -8 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.2 | CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
CHEMBL278751 | 98375 | 12 | None | -8 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.2 | CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
6604756 | 98375 | 12 | None | -8 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.2 | CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C | 10.1021/jm00073a021 | ||
CHEMBL278751 | 98375 | 12 | None | -8 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.2 | CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C | 10.1021/jm00073a021 | ||
164609529 | 183882 | 0 | None | -64 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 5 | 0 | 4 | 4.1 | CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4846823 | 183882 | 0 | None | -64 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 383 | 5 | 0 | 4 | 4.1 | CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O | 10.1016/j.ejmech.2021.113243 | ||
57390116 | 68956 | 0 | None | -77 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 925 | 30 | 2 | 13 | 5.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928122 | 68956 | 0 | None | -77 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 925 | 30 | 2 | 13 | 5.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
11732013 | 40568 | 0 | None | 12 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 395 | 1 | 1 | 5 | 4.8 | Clc1ccc2c(c1)C(N1CCN(C3CCCCC3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL148559 | 40568 | 0 | None | 12 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 395 | 1 | 1 | 5 | 4.8 | Clc1ccc2c(c1)C(N1CCN(C3CCCCC3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
6604756 | 98375 | 12 | None | -8 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.2 | CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C | 10.1016/S0960-894X(97)10068-3 | ||
CHEMBL278751 | 98375 | 12 | None | -8 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 275 | 6 | 0 | 2 | 4.2 | CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C | 10.1016/S0960-894X(97)10068-3 | ||
72190766 | 91928 | 0 | None | -12 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 391 | 8 | 0 | 6 | 3.6 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccccc3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL2430443 | 91928 | 0 | None | -12 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 391 | 8 | 0 | 6 | 3.6 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccccc3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
10831786 | 203812 | 0 | None | -2 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 351 | 4 | 1 | 2 | 5.5 | Clc1ccc(-c2cc(C3CCCCN3Cc3ccccc3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL80863 | 203812 | 0 | None | -2 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 351 | 4 | 1 | 2 | 5.5 | Clc1ccc(-c2cc(C3CCCCN3Cc3ccccc3)[nH]n2)cc1 | 10.1021/jm970111h | ||
156016177 | 177080 | 0 | None | -47 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 307 | 0 | 1 | 4 | 3.6 | CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3 | 10.1016/j.bmc.2020.115578 | ||
CHEMBL4641502 | 177080 | 0 | None | -47 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 307 | 0 | 1 | 4 | 3.6 | CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3 | 10.1016/j.bmc.2020.115578 | ||
16744005 | 143346 | 0 | None | -23 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 535 | 10 | 0 | 6 | 5.7 | COc1ccc(C2=NO[C@@H](CCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)C2)cc1OC | 10.1016/j.ejmech.2006.12.030 | ||
CHEMBL390181 | 143346 | 0 | None | -23 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 535 | 10 | 0 | 6 | 5.7 | COc1ccc(C2=NO[C@@H](CCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)C2)cc1OC | 10.1016/j.ejmech.2006.12.030 | ||
46231782 | 198819 | 0 | None | -2089 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 371 | 1 | 1 | 4 | 3.8 | COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL598730 | 198819 | 0 | None | -2089 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 371 | 1 | 1 | 4 | 3.8 | COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | ||
44415704 | 79749 | 0 | None | -1659 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 474 | 2 | 2 | 6 | 4.4 | Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL213424 | 79749 | 0 | None | -1659 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 474 | 2 | 2 | 6 | 4.4 | Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | ||
10242548 | 25400 | 34 | None | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CCCNC1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
CHEMBL135152 | 25400 | 34 | None | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 219 | 4 | 1 | 2 | 2.6 | CCCNC1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
118719792 | 115219 | 0 | None | -97 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 391 | 8 | 0 | 6 | 3.4 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccccc3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3353895 | 115219 | 0 | None | -97 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 391 | 8 | 0 | 6 | 3.4 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccccc3)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
21171 | 186393 | 27 | None | -8 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.1 | COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | ||
CHEMBL490533 | 186393 | 27 | None | -8 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 339 | 2 | 0 | 5 | 3.1 | COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | ||
56589561 | 70257 | 0 | None | -53 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO | 10.1021/jm200676f | ||
CHEMBL1949729 | 70257 | 0 | None | -53 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO | 10.1021/jm200676f | ||
13091358 | 70112 | 0 | None | -12 | 6 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946122 | 70112 | 0 | None | -12 | 6 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
9845181 | 206420 | 1 | None | -34 | 14 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 423 | 4 | 0 | 4 | 3.3 | C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O | 10.1021/jm020938y | ||
CHEMBL98241 | 206420 | 1 | None | -34 | 14 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 423 | 4 | 0 | 4 | 3.3 | C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O | 10.1021/jm020938y | ||
13091356 | 113039 | 0 | None | -12 | 8 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL3321789 | 113039 | 0 | None | -12 | 8 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
44276155 | 99032 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCCNC(=O)C2CCCc3cccc(OC)c32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL283211 | 99032 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCN(CCCNC(=O)C2CCCc3cccc(OC)c32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
72164180 | 91713 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420772 | 91713 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
118709165 | 112912 | 0 | None | -22 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 916 | 23 | 0 | 8 | 12.1 | O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318837 | 112912 | 0 | None | -22 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 916 | 23 | 0 | 8 | 12.1 | O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
118709167 | 112914 | 0 | None | -5 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 972 | 27 | 0 | 8 | 13.6 | O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318839 | 112914 | 0 | None | -5 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 972 | 27 | 0 | 8 | 13.6 | O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
25141534 | 55942 | 0 | None | -1698 | 7 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
CHEMBL1627305 | 55942 | 0 | None | -1698 | 7 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 460 | 7 | 3 | 4 | 3.8 | O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
146025727 | 171119 | 0 | None | -181 | 27 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
CHEMBL4466483 | 171119 | 0 | None | -181 | 27 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
11016418 | 105642 | 0 | None | -7943 | 9 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 488 | 6 | 0 | 7 | 4.2 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL313424 | 105642 | 0 | None | -7943 | 9 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 488 | 6 | 0 | 7 | 4.2 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
137645196 | 157415 | 0 | None | -117 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 277 | 1 | 2 | 5 | 0.9 | CN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4084712 | 157415 | 0 | None | -117 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 277 | 1 | 2 | 5 | 0.9 | CN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
49798855 | 14195 | 0 | None | -234 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 3 | 0 | 4 | 3.7 | CN1CN(c2ccccc2)C2(CCN(Cc3coc4ccccc34)CC2)C1=O | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1169896 | 14195 | 0 | None | -234 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 3 | 0 | 4 | 3.7 | CN1CN(c2ccccc2)C2(CCN(Cc3coc4ccccc34)CC2)C1=O | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1199933 | 14195 | 0 | None | -234 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 3 | 0 | 4 | 3.7 | CN1CN(c2ccccc2)C2(CCN(Cc3coc4ccccc34)CC2)C1=O | 10.1016/j.bmc.2010.05.052 | ||
10597114 | 171283 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 400 | 4 | 1 | 3 | 5.0 | OC1(c2cccc(C(F)(F)F)c2)CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
CHEMBL446892 | 171283 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 400 | 4 | 1 | 3 | 5.0 | OC1(c2cccc(C(F)(F)F)c2)CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
71061585 | 159950 | 0 | None | -3 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 367 | 6 | 0 | 5 | 2.8 | Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1 | nan | ||
CHEMBL4112090 | 159950 | 0 | None | -3 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 367 | 6 | 0 | 5 | 2.8 | Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1 | nan | ||
CHEMBL4752561 | 212279 | 0 | None | -3 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | None | None | None | COc1cc(-c2cn([C@H]3CCc4ccccc4N(CC(F)(F)F)C3=O)nn2)ccc1-n1ccc(C)n1 | nan | ||||
164619236 | 185127 | 0 | None | -25 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 2.6 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4865591 | 185127 | 0 | None | -25 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 2.6 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
10551026 | 101146 | 0 | None | -6 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 4.6 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL298875 | 101146 | 0 | None | -6 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 4.6 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
9821803 | 126944 | 0 | None | 524 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL366043 | 126944 | 0 | None | 524 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
131396 | 205008 | 6 | None | 1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 4.6 | CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
CHEMBL89934 | 205008 | 6 | None | 1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 4.6 | CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1 | 10.1021/jm960268u | ||
10641783 | 42434 | 0 | None | 354 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 353 | 4 | 1 | 5 | 2.3 | COc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL150129 | 42434 | 0 | None | 354 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 353 | 4 | 1 | 5 | 2.3 | COc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
9820304 | 101599 | 0 | None | 12 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL1204116 | 101599 | 0 | None | 12 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL302075 | 101599 | 0 | None | 12 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1 | 10.1016/s0960-894x(00)00421-2 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00656-x | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00656-x | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00656-x | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/s0960-894x(02)00656-x | ||
44336047 | 4717 | 0 | None | 57 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL104058 | 4717 | 0 | None | 57 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335925 | 4876 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 413 | 5 | 0 | 4 | 3.4 | COc1ccc(Cl)cc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL104751 | 4876 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 413 | 5 | 0 | 4 | 3.4 | COc1ccc(Cl)cc1CN1CCN(CC(=O)N2c3ccccc3C[C@H]2C)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335835 | 5006 | 0 | None | 1174 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 3.8 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C(F)(F)F)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL105454 | 5006 | 0 | None | 1174 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 3.8 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C(F)(F)F)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
9867233 | 5427 | 0 | None | 234 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 427 | 5 | 0 | 5 | 2.6 | COC(=O)[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL107631 | 5427 | 0 | None | 234 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 427 | 5 | 0 | 5 | 2.6 | COC(=O)[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
9865490 | 167386 | 0 | None | 53 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 395 | 5 | 0 | 3 | 3.6 | C=C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL431640 | 167386 | 0 | None | 53 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 395 | 5 | 0 | 3 | 3.6 | C=C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335795 | 4932 | 0 | None | 33 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 362 | 4 | 0 | 2 | 4.6 | Cc1cccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)c1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL105011 | 4932 | 0 | None | 33 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 362 | 4 | 0 | 2 | 4.6 | Cc1cccc(CN2CCC(CC(=O)N3c4ccccc4CC3C)CC2)c1 | 10.1016/s0960-894x(02)00655-8 | ||
44335816 | 5146 | 0 | None | 758 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 5 | 0 | 4 | 3.7 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106208 | 5146 | 0 | None | 758 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 5 | 0 | 4 | 3.7 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
10157556 | 119730 | 0 | None | 21 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 395 | 3 | 0 | 3 | 3.4 | O=C1C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2cccc3c2N1CC3 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL352207 | 119730 | 0 | None | 21 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 395 | 3 | 0 | 3 | 3.4 | O=C1C(N2CCN(Cc3ccc(Cl)cc3)CC2)CCc2cccc3c2N1CC3 | 10.1016/s0960-894x(02)01056-9 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | ||
11668034 | 133004 | 0 | None | 2 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 380 | 5 | 1 | 3 | 4.6 | O=C(N[C@H]1CCN(Cc2ccc(F)cc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL370823 | 133004 | 0 | None | 2 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 380 | 5 | 1 | 3 | 4.6 | O=C(N[C@H]1CCN(Cc2ccc(F)cc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
22100940 | 202256 | 4 | None | 112 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 306 | 3 | 0 | 3 | 4.6 | C1=C(c2nc3ccccc3s2)CCN(Cc2ccccc2)C1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL69355 | 202256 | 4 | None | 112 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 306 | 3 | 0 | 3 | 4.6 | C1=C(c2nc3ccccc3s2)CCN(Cc2ccccc2)C1 | 10.1016/S0960-894X(97)00402-2 | ||
19958507 | 98962 | 0 | None | 81 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.4 | CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL282829 | 98962 | 0 | None | 81 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.4 | CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
10715375 | 198019 | 0 | None | 630 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 4.9 | COc1cc2ccccc2cc1C(=O)OCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL59326 | 198019 | 0 | None | 630 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 4.9 | COc1cc2ccccc2cc1C(=O)OCC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
10525119 | 79329 | 6 | None | 79 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 3.8 | O=C(NCCN1CCN(c2ccc(Cl)cc2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21168 | 79329 | 6 | None | 79 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 3.8 | O=C(NCCN1CCN(c2ccc(Cl)cc2)CC1)C12CC3CC(CC(C3)C1)C2 | 10.1016/0960-894X(96)00198-9 | ||
76325156 | 105909 | 1 | None | -7 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | ||
CHEMBL3115585 | 105909 | 1 | None | -7 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | ||
CHEMBL3139393 | 105909 | 1 | None | -7 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | ||
10049549 | 82853 | 0 | None | 537 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 452 | 3 | 0 | 4 | 3.9 | Clc1ccc(N2CCN(Cc3cnn4c(I)cccc34)CC2)cc1 | 10.1021/jm0611152 | ||
CHEMBL218787 | 82853 | 0 | None | 537 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 452 | 3 | 0 | 4 | 3.9 | Clc1ccc(N2CCN(Cc3cnn4c(I)cccc34)CC2)cc1 | 10.1021/jm0611152 | ||
9968343 | 42494 | 0 | None | 169 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 351 | 3 | 1 | 4 | 3.0 | Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1C | 10.1021/jm990277d | ||
CHEMBL150181 | 42494 | 0 | None | 169 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 351 | 3 | 1 | 4 | 3.0 | Cc1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1C | 10.1021/jm990277d | ||
155563452 | 174737 | 0 | None | 6 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 361 | 6 | 0 | 4 | 3.7 | O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4573441 | 174737 | 0 | None | 6 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 361 | 6 | 0 | 4 | 3.7 | O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
145967572 | 164381 | 0 | None | 1 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 275 | 8 | 1 | 2 | 4.5 | CCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4224763 | 164381 | 0 | None | 1 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 275 | 8 | 1 | 2 | 4.5 | CCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
72545238 | 92695 | 0 | None | 25 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 425 | 9 | 0 | 7 | 3.3 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443005 | 92695 | 0 | None | 25 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 425 | 9 | 0 | 7 | 3.3 | COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
155563452 | 174737 | 0 | None | 6 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 361 | 6 | 0 | 4 | 3.7 | O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4573441 | 174737 | 0 | None | 6 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 361 | 6 | 0 | 4 | 3.7 | O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
10643589 | 205735 | 0 | None | 13 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2cccc(Cl)c2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL94283 | 205735 | 0 | None | 13 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 5.1 | Cc1c(-c2cccc(Cl)c2)nc(O)n1C1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
3691783 | 4696 | 1 | None | 47 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 318 | 4 | 1 | 3 | 3.4 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
CHEMBL103871 | 4696 | 1 | None | 47 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 318 | 4 | 1 | 3 | 3.4 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
11797442 | 106543 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 4.1 | COc1cc(NC(=O)C2CCC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL315446 | 106543 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 4.1 | COc1cc(NC(=O)C2CCC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
127031832 | 138885 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793782 | 138885 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.6 | Fc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
137651073 | 156926 | 0 | None | 2 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 405 | 8 | 0 | 7 | 3.2 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4079301 | 156926 | 0 | None | 2 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 405 | 8 | 0 | 7 | 3.2 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
10360923 | 91120 | 2 | None | 831 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 356 | 4 | 0 | 4 | 4.6 | Cc1c(-c2ccccc2)cnn1C1CCN(Cc2cccc(C#N)c2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
CHEMBL24052 | 91120 | 2 | None | 831 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 356 | 4 | 0 | 4 | 4.6 | Cc1c(-c2ccccc2)cnn1C1CCN(Cc2cccc(C#N)c2)CC1 | 10.1016/s0960-894x(99)00169-9 | ||
10737474 | 100883 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL296953 | 100883 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
9975465 | 187068 | 0 | None | 109 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL49502 | 187068 | 0 | None | 109 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
137661377 | 158663 | 0 | None | 173 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 314 | 6 | 0 | 2 | 3.9 | CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4098720 | 158663 | 0 | None | 173 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 314 | 6 | 0 | 2 | 3.9 | CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
44412191 | 137847 | 0 | None | 60 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1 | 10.1021/jm0611152 | ||
CHEMBL377200 | 137847 | 0 | None | 60 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1 | 10.1021/jm0611152 | ||
10737474 | 100883 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1021/jm970021c | ||
CHEMBL296953 | 100883 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1021/jm970021c | ||
13091268 | 77845 | 0 | None | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL210578 | 77845 | 0 | None | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
13091268 | 77845 | 0 | None | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
CHEMBL210578 | 77845 | 0 | None | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
13091268 | 77845 | 0 | None | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL210578 | 77845 | 0 | None | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
25071691 | 111295 | 0 | None | -9 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
CHEMBL3287403 | 111295 | 0 | None | -9 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
44412191 | 137847 | 0 | None | 60 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL377200 | 137847 | 0 | None | 60 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 332 | 4 | 0 | 4 | 3.5 | Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1 | 10.1016/j.bmcl.2006.02.075 | ||
71734031 | 90629 | 0 | None | -21 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 9 | 1 | 3 | 5.2 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397479 | 90629 | 0 | None | -21 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 9 | 1 | 3 | 5.2 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1 | 10.1021/jm400520c | ||
10133031 | 57234 | 0 | None | 38 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 358 | 4 | 0 | 3 | 3.9 | Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ccc(F)cc4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
CHEMBL166321 | 57234 | 0 | None | 38 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 358 | 4 | 0 | 3 | 3.9 | Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ccc(F)cc4)CCN3C2)cc1 | 10.1016/s0960-894x(98)00108-5 | ||
10518406 | 18690 | 0 | None | 69 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 301 | 10 | 1 | 4 | 3.1 | COc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL128276 | 18690 | 0 | None | 69 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 301 | 10 | 1 | 4 | 3.1 | COc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
10518406 | 18690 | 0 | None | 69 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 301 | 10 | 1 | 4 | 3.1 | COc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
CHEMBL128276 | 18690 | 0 | None | 69 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 301 | 10 | 1 | 4 | 3.1 | COc1ccc(OCCNCCCOc2ccccc2)cc1 | 10.1021/jm970422s | ||
9952003 | 5288 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106916 | 5288 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
10000302 | 205491 | 0 | None | 109 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 3.3 | COc1cccc(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL92713 | 205491 | 0 | None | 109 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 3.3 | COc1cccc(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm020952a | ||
127031831 | 138810 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792805 | 138810 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.5 | COc1ccc2c(CN3CCO[C@H](COc4ccccc4)C3)c[nH]c2c1 | 10.1016/j.bmcl.2016.03.102 | ||
11504230 | 77840 | 0 | None | -12 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 497 | 8 | 1 | 4 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm060138d | ||
CHEMBL210567 | 77840 | 0 | None | -12 | 7 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 497 | 8 | 1 | 4 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm060138d | ||
53364153 | 63510 | 0 | None | 3 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 929 | 25 | 0 | 16 | 7.7 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803023 | 63510 | 0 | None | 3 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 929 | 25 | 0 | 16 | 7.7 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
11233944 | 4715 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 366 | 5 | 2 | 4 | 4.0 | Oc1cc(Cl)ccc1NCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104041 | 4715 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 366 | 5 | 2 | 4 | 4.0 | Oc1cc(Cl)ccc1NCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
10000302 | 205491 | 0 | None | 109 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 3.3 | COc1cccc(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
CHEMBL92713 | 205491 | 0 | None | 109 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 387 | 7 | 1 | 4 | 3.3 | COc1cccc(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm991138z | ||
10760638 | 187593 | 0 | None | 131 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL49876 | 187593 | 0 | None | 131 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
57396571 | 69822 | 0 | None | 3 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 3.9 | Clc1ccc(N2CCN(CCCOc3ccccc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940413 | 69822 | 0 | None | 3 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 3.9 | Clc1ccc(N2CCN(CCCOc3ccccc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
10618874 | 201456 | 0 | None | 95 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 1 | 2 | 5.2 | Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL6416 | 201456 | 0 | None | 95 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 1 | 2 | 5.2 | Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10667201 | 110904 | 0 | None | 60 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 4 | 4.8 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(CCCc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL327176 | 110904 | 0 | None | 60 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 6 | 1 | 4 | 4.8 | Cc1c(-c2ccccc2)nc(O)n1C1CCN(CCCc2ccccc2)CC1 | 10.1021/jm991029k | ||
10546453 | 111211 | 0 | None | 27 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 4 | 2 | 3 | 4.0 | O=C(Nc1nccc2ccccc12)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
CHEMBL328667 | 111211 | 0 | None | 27 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 4 | 2 | 3 | 4.0 | O=C(Nc1nccc2ccccc12)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm991029k | ||
10760638 | 187593 | 0 | None | 131 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1021/jm970021c | ||
CHEMBL49876 | 187593 | 0 | None | 131 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 354 | 4 | 1 | 4 | 2.7 | N#Cc1ccccc1N1CCN(CNC(=O)c2ccc(Cl)cc2)CC1 | 10.1021/jm970021c | ||
10618874 | 201456 | 0 | None | 95 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 1 | 2 | 5.2 | Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm0002432 | ||
CHEMBL6416 | 201456 | 0 | None | 95 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 1 | 2 | 5.2 | Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm0002432 | ||
168280742 | 190490 | 0 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 230 | 4 | 0 | 2 | 3.5 | O=Cc1ccc(-c2ccccc2OCF)cc1 | 10.1021/acs.jmedchem.2c00949 | ||
CHEMBL5187578 | 190490 | 0 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 230 | 4 | 0 | 2 | 3.5 | O=Cc1ccc(-c2ccccc2OCF)cc1 | 10.1021/acs.jmedchem.2c00949 | ||
145969667 | 164413 | 0 | None | -1 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4225278 | 164413 | 0 | None | -1 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
10618874 | 201456 | 0 | None | 95 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 1 | 2 | 5.2 | Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm960072u | ||
CHEMBL6416 | 201456 | 0 | None | 95 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 1 | 2 | 5.2 | Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm960072u | ||
11774177 | 5311 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 407 | 6 | 0 | 4 | 4.9 | CC(=O)c1ccc(Cl)cc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL107068 | 5311 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 407 | 6 | 0 | 4 | 4.9 | CC(=O)c1ccc(Cl)cc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL4513786 | 212217 | 5 | None | 34 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | None | None | None | CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC | nan | ||||
CHEMBL4796803 | 212217 | 5 | None | 34 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | None | None | None | CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC | nan | ||||
10693793 | 107215 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 427 | 7 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL319079 | 107215 | 0 | None | 10 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 427 | 7 | 2 | 4 | 3.7 | COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
10758004 | 21211 | 0 | None | 31 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1021/jm970422s | ||
CHEMBL131484 | 21211 | 0 | None | 31 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1021/jm970422s | ||
57396571 | 69822 | 0 | None | 3 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 3.9 | Clc1ccc(N2CCN(CCCOc3ccccc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940413 | 69822 | 0 | None | 3 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 3.9 | Clc1ccc(N2CCN(CCCOc3ccccc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57396571 | 69822 | 0 | None | 3 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 3.9 | Clc1ccc(N2CCN(CCCOc3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940413 | 69822 | 0 | None | 3 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 330 | 6 | 0 | 3 | 3.9 | Clc1ccc(N2CCN(CCCOc3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
19964410 | 159151 | 1 | None | 70 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OCC2CN(Cc3c[nH]c4ccccc34)CCO2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL4104272 | 159151 | 1 | None | 70 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.4 | c1ccc(OCC2CN(Cc3c[nH]c4ccccc34)CCO2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
10758004 | 21211 | 0 | None | 31 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL131484 | 21211 | 0 | None | 31 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.1 | Cc1ccc(OCCCNCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
6466372 | 169495 | 12 | None | 93 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4443054 | 169495 | 12 | None | 93 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 311 | 4 | 1 | 5 | 1.5 | Cc1cccc(NC(=O)CN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
15467371 | 100538 | 0 | None | 912 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 3.4 | N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL294458 | 100538 | 0 | None | 912 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 3.4 | N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
45482152 | 196333 | 0 | None | 20 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 517 | 9 | 1 | 8 | 3.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1 | 10.1016/j.bmc.2009.06.041 | ||
CHEMBL573792 | 196333 | 0 | None | 20 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 517 | 9 | 1 | 8 | 3.8 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1 | 10.1016/j.bmc.2009.06.041 | ||
57401706 | 69828 | 0 | None | 1 | 11 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940419 | 69828 | 0 | None | 1 | 11 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57401706 | 69828 | 0 | None | 1 | 11 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940419 | 69828 | 0 | None | 1 | 11 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
25071692 | 111297 | 0 | None | -13 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 443 | 7 | 0 | 6 | 4.5 | N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
CHEMBL3287405 | 111297 | 0 | None | -13 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 443 | 7 | 0 | 6 | 4.5 | N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
76325156 | 105909 | 1 | None | -7 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | ||
CHEMBL3115585 | 105909 | 1 | None | -7 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | ||
CHEMBL3139393 | 105909 | 1 | None | -7 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | ||
44364166 | 40572 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 280 | 5 | 2 | 4 | 3.3 | O=c1ccc2ccc(NCCNc3ccccc3)cc2o1 | 10.1021/jm0002432 | ||
CHEMBL148561 | 40572 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 280 | 5 | 2 | 4 | 3.3 | O=c1ccc2ccc(NCCNc3ccccc3)cc2o1 | 10.1021/jm0002432 | ||
9926143 | 113027 | 1 | None | 74 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 294 | 6 | 2 | 4 | 3.0 | O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL332154 | 113027 | 1 | None | 74 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 294 | 6 | 2 | 4 | 3.0 | O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1 | 10.1021/jm990266k | ||
127031515 | 138904 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL3793910 | 138904 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.1 | COc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1F | 10.1016/j.bmcl.2022.128615 | ||
145969667 | 164413 | 0 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4225278 | 164413 | 0 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | ||
52919 | 14317 | 43 | None | -3 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 529 | 15 | 0 | 4 | 8.1 | CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL1200986 | 14317 | 43 | None | -3 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 529 | 15 | 0 | 4 | 8.1 | CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
71733932 | 90621 | 0 | None | -25 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397389 | 90621 | 0 | None | -25 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm400520c | ||
10378194 | 196088 | 0 | None | 45 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 265 | 3 | 1 | 2 | 2.3 | C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL57176 | 196088 | 0 | None | 45 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 265 | 3 | 1 | 2 | 2.3 | C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1 | 10.1016/s0960-894x(02)00316-5 | ||
155523515 | 170298 | 0 | None | 12 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 567 | 11 | 2 | 5 | 5.9 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(-c3ccccc3)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4454096 | 170298 | 0 | None | 12 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 567 | 11 | 2 | 5 | 5.9 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(-c3ccccc3)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
155555060 | 173753 | 0 | None | 14 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1cccc(CN(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c2ccc(F)cc2)c1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4550633 | 173753 | 0 | None | 14 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1cccc(CN(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c2ccc(F)cc2)c1 | 10.1021/acs.jmedchem.9b01085 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.06.079 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.06.079 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.06.079 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.06.079 | ||
44278479 | 162592 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 359 | 7 | 0 | 2 | 5.6 | c1ccc(CC2CCN(CCCOc3cccc4ccccc34)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL417858 | 162592 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 359 | 7 | 0 | 2 | 5.6 | c1ccc(CC2CCN(CCCOc3cccc4ccccc34)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
135887934 | 11227 | 0 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 379 | 7 | 1 | 6 | 3.1 | c1ccc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1179502 | 11227 | 0 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 379 | 7 | 1 | 6 | 3.1 | c1ccc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL80627 | 11227 | 0 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 379 | 7 | 1 | 6 | 3.1 | c1ccc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)nc1 | 10.1016/S0960-894X(97)00442-3 | ||
10084583 | 104299 | 3 | None | -93 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 271 | 5 | 0 | 3 | 3.3 | CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL310867 | 104299 | 3 | None | -93 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 271 | 5 | 0 | 3 | 3.3 | CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1 | 10.1016/s0960-894x(02)00390-6 | ||
10639430 | 168603 | 1 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(-c2nc(CN3CCN(c4cnccn4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
CHEMBL440511 | 168603 | 1 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 4 | 1 | 5 | 2.2 | c1ccc(-c2nc(CN3CCN(c4cnccn4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
44454707 | 97382 | 0 | None | 21 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.0 | FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL272073 | 97382 | 0 | None | 21 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.0 | FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.12.026 | ||
44335987 | 4745 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 425 | 4 | 0 | 3 | 4.8 | CC1CC(C)(C)N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104160 | 4745 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 425 | 4 | 0 | 3 | 4.8 | CC1CC(C)(C)N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
132578545 | 154021 | 0 | None | -104 | 9 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3898250 | 154021 | 0 | None | -104 | 9 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991133 | 154021 | 0 | None | -104 | 9 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
135398745 | 2869 | 108 | None | -7 | 65 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2014.07.018 | ||
47 | 2869 | 108 | None | -7 | 65 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL715 | 2869 | 108 | None | -7 | 65 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2014.07.018 | ||
DB00334 | 2869 | 108 | None | -7 | 65 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2014.07.018 | ||
10663221 | 33491 | 1 | None | 60 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1 | 10.1021/jm0009989 | ||
CHEMBL142217 | 33491 | 1 | None | 60 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 316 | 3 | 1 | 3 | 3.4 | N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1 | 10.1021/jm0009989 | ||
22727323 | 13030 | 0 | None | -8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 436 | 9 | 0 | 7 | 4.4 | COc1ccccc1N1CCN(CCCCc2cc(-c3cccc([N+](=O)[O-])c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1190607 | 13030 | 0 | None | -8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 436 | 9 | 0 | 7 | 4.4 | COc1ccccc1N1CCN(CCCCc2cc(-c3cccc([N+](=O)[O-])c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL541270 | 13030 | 0 | None | -8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 436 | 9 | 0 | 7 | 4.4 | COc1ccccc1N1CCN(CCCCc2cc(-c3cccc([N+](=O)[O-])c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
44270444 | 49059 | 0 | None | 138 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 3.6 | Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL156369 | 49059 | 0 | None | 138 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 3.6 | Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1016/s0960-894x(01)00814-9 | ||
44273882 | 77849 | 0 | None | 79 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 385 | 6 | 1 | 3 | 3.8 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL21059 | 77849 | 0 | None | 79 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 385 | 6 | 1 | 3 | 3.8 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
10939222 | 202697 | 1 | None | -100 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1 | 10.1016/0960-894X(95)00011-H | ||
CHEMBL71960 | 202697 | 1 | None | -100 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 3.8 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1 | 10.1016/0960-894X(95)00011-H | ||
132578545 | 154021 | 0 | None | -104 | 9 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3898250 | 154021 | 0 | None | -104 | 9 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3991133 | 154021 | 0 | None | -104 | 9 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 325 | 3 | 0 | 2 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1 | 10.1016/j.bmc.2016.09.019 | ||
2865 | 4079 | 67 | None | -66 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
59 | 4079 | 67 | None | -66 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
60854 | 4079 | 67 | None | -66 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
CHEMBL708 | 4079 | 67 | None | -66 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
DB00246 | 4079 | 67 | None | -66 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
44340415 | 8492 | 0 | None | 1 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 5 | 1 | 3 | 5.3 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL109472 | 8492 | 0 | None | 1 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 5 | 1 | 3 | 5.3 | COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
44340302 | 9660 | 0 | None | 1 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 466 | 7 | 1 | 3 | 5.3 | COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL113471 | 9660 | 0 | None | 1 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 466 | 7 | 1 | 3 | 5.3 | COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
44332686 | 206682 | 0 | None | -44 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 320 | 8 | 2 | 4 | 2.2 | CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL99849 | 206682 | 0 | None | -44 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 320 | 8 | 2 | 4 | 2.2 | CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1 | 10.1016/s0960-894x(98)00014-6 | ||
130431290 | 173463 | 0 | None | -436 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 417 | 9 | 2 | 4 | 3.5 | CCc1c[nH]c(C(=O)NCCCCN2CCN(c3cccc(CC)c3Cl)CC2)n1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4543524 | 173463 | 0 | None | -436 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 417 | 9 | 2 | 4 | 3.5 | CCc1c[nH]c(C(=O)NCCCCN2CCN(c3cccc(CC)c3Cl)CC2)n1 | 10.1021/acs.jmedchem.6b00860 | ||
72545009 | 92692 | 0 | None | -1 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 6 | 3 | 10 | -0.4 | COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443002 | 92692 | 0 | None | -1 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 6 | 3 | 10 | -0.4 | COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
11659604 | 138045 | 0 | None | 30 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 311 | 3 | 0 | 5 | 2.2 | Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL377542 | 138045 | 0 | None | 30 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 311 | 3 | 0 | 5 | 2.2 | Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1 | 10.1021/jm060166w | ||
10034684 | 69064 | 63 | None | 18 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 135 | 0 | 2 | 2 | 1.4 | Oc1ccc2c(c1)CCN2 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL19331 | 69064 | 63 | None | 18 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 135 | 0 | 2 | 2 | 1.4 | Oc1ccc2c(c1)CCN2 | 10.1016/S0960-894X(97)00194-7 | ||
155568411 | 175506 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 331 | 4 | 1 | 5 | 1.9 | O=C(CN1CCN(c2ccc(Cl)cn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4591118 | 175506 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 331 | 4 | 1 | 5 | 1.9 | O=C(CN1CCN(c2ccc(Cl)cn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
137647533 | 157410 | 0 | None | -81 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 477 | 7 | 2 | 7 | 3.8 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5oc(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4084690 | 157410 | 0 | None | -81 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 477 | 7 | 2 | 7 | 3.8 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5oc(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
11154555 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
5037 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
7671 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL2028019 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL3085826 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
DB06016 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
164619236 | 185127 | 0 | None | -25 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 2.6 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4865591 | 185127 | 0 | None | -25 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 2.6 | O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1 | 10.1016/j.ejmech.2021.113243 | ||
154704705 | 175751 | 1 | None | -2 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 440 | 11 | 1 | 6 | 4.9 | CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4590356 | 175751 | 1 | None | -2 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 440 | 11 | 1 | 6 | 4.9 | CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595409 | 175751 | 1 | None | -2 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 440 | 11 | 1 | 6 | 4.9 | CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL5074399 | 212545 | 0 | None | -19 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | CCc1cccc(N2CCN(CCCCNCCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1Cl | 10.1021/acs.jmedchem.1c00611 | ||||
130431336 | 174336 | 0 | None | -389 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.0 | CCc1cccc(N2CCN(C/C=C/CNC(=O)c3nc(C)c[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4564507 | 174336 | 0 | None | -389 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 401 | 7 | 2 | 4 | 3.0 | CCc1cccc(N2CCN(C/C=C/CNC(=O)c3nc(C)c[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
71062579 | 147698 | 0 | None | - | 1 | Mouse | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 353 | 6 | 0 | 5 | 2.5 | Cc1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cn1 | nan | ||
CHEMBL3936182 | 147698 | 0 | None | - | 1 | Mouse | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 353 | 6 | 0 | 5 | 2.5 | Cc1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cn1 | nan | ||
44427970 | 152078 | 0 | None | -9 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 325 | 2 | 0 | 3 | 3.7 | COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | ||
CHEMBL397207 | 152078 | 0 | None | -9 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 325 | 2 | 0 | 3 | 3.7 | COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | ||
11269330 | 199808 | 0 | None | -16595 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 390 | 1 | 1 | 3 | 5.0 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL605127 | 199808 | 0 | None | -16595 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 390 | 1 | 1 | 3 | 5.0 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
44330637 | 206433 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 198 | 0 | 0 | 2 | 2.6 | Cn1cc2c(n1)-c1ccccc1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL98330 | 206433 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 198 | 0 | 0 | 2 | 2.6 | Cn1cc2c(n1)-c1ccccc1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
11154555 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
5037 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
7671 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL2028019 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL3085826 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
DB06016 | 788 | 57 | None | -501 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.1c01327 | ||
16744171 | 92125 | 0 | None | -245 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 453 | 10 | 0 | 7 | 4.2 | CCOc1ccccc1N1CCN(CCC[C@@H]2CC(c3ccc(OC)c(OC)c3)=NO2)CC1 | 10.1016/j.ejmech.2006.12.030 | ||
CHEMBL243224 | 92125 | 0 | None | -245 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 453 | 10 | 0 | 7 | 4.2 | CCOc1ccccc1N1CCN(CCC[C@@H]2CC(c3ccc(OC)c(OC)c3)=NO2)CC1 | 10.1016/j.ejmech.2006.12.030 | ||
57345620 | 70150 | 0 | None | -32 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1[C@H]2CC[C@@H]1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946744 | 70150 | 0 | None | -32 | 3 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1[C@H]2CC[C@@H]1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
76518515 | 140339 | 0 | None | -31 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818881 | 140339 | 0 | None | -31 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819714 | 140339 | 0 | None | -31 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
13373172 | 198101 | 0 | None | -125 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 251 | 0 | 1 | 2 | 3.0 | Oc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL593897 | 198101 | 0 | None | -125 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 251 | 0 | 1 | 2 | 3.0 | Oc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | ||
44335721 | 106819 | 0 | None | 50 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 387 | 4 | 0 | 3 | 3.2 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccc(F)cc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL317266 | 106819 | 0 | None | 50 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 387 | 4 | 0 | 3 | 3.2 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccc(F)cc21 | 10.1016/s0960-894x(02)00655-8 | ||
127030909 | 138951 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 367 | 6 | 0 | 4 | 3.9 | FC(F)(F)Oc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794375 | 138951 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 367 | 6 | 0 | 4 | 3.9 | FC(F)(F)Oc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
57402787 | 68853 | 0 | None | -14 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 977 | 28 | 2 | 17 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1926700 | 68853 | 0 | None | -14 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 977 | 28 | 2 | 17 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
44276111 | 12801 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 450 | 10 | 0 | 7 | 4.8 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3cccc([N+](=O)[O-])c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1189040 | 12801 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 450 | 10 | 0 | 7 | 4.8 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3cccc([N+](=O)[O-])c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL537975 | 12801 | 0 | None | -2 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 450 | 10 | 0 | 7 | 4.8 | CCOc1ccccc1N1CCN(CCCCc2cc(-c3cccc([N+](=O)[O-])c3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
10247720 | 12943 | 0 | None | 2 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL1190042 | 12943 | 0 | None | 2 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL540039 | 12943 | 0 | None | 2 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
60165543 | 74997 | 0 | None | 1 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 367 | 6 | 0 | 7 | 2.9 | O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037519 | 74997 | 0 | None | 1 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 367 | 6 | 0 | 7 | 2.9 | O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
9881815 | 204941 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 267 | 6 | 2 | 3 | 2.7 | c1ccc(CNCCOc2cccc3[nH]cnc23)cc1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL89420 | 204941 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 267 | 6 | 2 | 3 | 2.7 | c1ccc(CNCCOc2cccc3[nH]cnc23)cc1 | 10.1016/s0960-894x(99)00434-5 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2020.115943 | ||
122180574 | 121212 | 0 | None | -512 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.2 | Clc1cccc(N2CCN(CCCCc3cn(-c4ccc5[nH]ccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588919 | 121212 | 0 | None | -512 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.2 | Clc1cccc(N2CCN(CCCCc3cn(-c4ccc5[nH]ccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.01.017 | ||
154725277 | 175858 | 1 | None | -19 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4472900 | 175858 | 1 | None | -19 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596220 | 175858 | 1 | None | -19 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113243 | ||
242 | 467 | 117 | None | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
34 | 467 | 117 | None | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
60795 | 467 | 117 | None | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL1112 | 467 | 117 | None | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
DB01238 | 467 | 117 | None | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
135501649 | 119261 | 0 | None | 5 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 321 | 1 | 2 | 5 | 3.2 | Cc1ccc2c(c1)C(NC1CCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL347959 | 119261 | 0 | None | 5 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 321 | 1 | 2 | 5 | 3.2 | Cc1ccc2c(c1)C(NC1CCN(C)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
71449034 | 78014 | 0 | None | 3 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.5 | COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL2111526 | 78014 | 0 | None | 3 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.5 | COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
60165545 | 75005 | 0 | None | -2 | 4 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 4 | 4.7 | O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037527 | 75005 | 0 | None | -2 | 4 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 4 | 4.7 | O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
76518515 | 140339 | 0 | None | -31 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818881 | 140339 | 0 | None | -31 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819714 | 140339 | 0 | None | -31 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 7 | 1 | 5 | 5.8 | O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 | 10.1016/j.bmc.2016.06.011 | ||
44456400 | 12725 | 0 | None | -21 | 10 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
CHEMBL1188501 | 12725 | 0 | None | -21 | 10 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
CHEMBL2436555 | 12725 | 0 | None | -21 | 10 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
CHEMBL536539 | 12725 | 0 | None | -21 | 10 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
44591088 | 188991 | 0 | None | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 372 | 6 | 0 | 3 | 4.6 | O=C(CCCN1CC2CC1N(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL514591 | 188991 | 0 | None | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 372 | 6 | 0 | 3 | 4.6 | O=C(CCCN1CC2CC1N(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
44438236 | 154361 | 2 | None | -173 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 354 | 3 | 1 | 3 | 4.3 | Cn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL400827 | 154361 | 2 | None | -173 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 354 | 3 | 1 | 3 | 4.3 | Cn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.10.076 | ||
100 | 3745 | 52 | None | -8 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
2637 | 3745 | 52 | None | -8 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
5452 | 3745 | 52 | None | -8 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
CHEMBL479 | 3745 | 52 | None | -8 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
DB00679 | 3745 | 52 | None | -8 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
10806501 | 203572 | 0 | None | 24 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.9 | c1ccc(CCN2CCC(c3cc(-c4ccncc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL79098 | 203572 | 0 | None | 24 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.9 | c1ccc(CCN2CCC(c3cc(-c4ccncc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
9857248 | 203394 | 6 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
CHEMBL77708 | 203394 | 6 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 3 | 1 | 3 | 2.9 | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
44278458 | 99229 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 7 | 1 | 3 | 4.8 | Cc1ccc(CC2CCN(CC(O)COc3cccc4ccccc34)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL28458 | 99229 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 7 | 1 | 3 | 4.8 | Cc1ccc(CC2CCN(CC(O)COc3cccc4ccccc34)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
136072267 | 13062 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.7 | c1ccc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL1190896 | 13062 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.7 | c1ccc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL541826 | 13062 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 7 | 1 | 5 | 3.7 | c1ccc(N2CCN(CCCCCNC3=Nc4ccccc4OC3)CC2)cc1 | 10.1016/S0960-894X(97)00442-3 | ||
23992579 | 91712 | 5 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 3 | 0 | 3 | 3.7 | Clc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420771 | 91712 | 5 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 3 | 0 | 3 | 3.7 | Clc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
3251 | 4009 | 50 | None | -43 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
5684 | 4009 | 50 | None | -43 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
80 | 4009 | 50 | None | -43 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL31354 | 4009 | 50 | None | -43 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
44405445 | 135254 | 0 | None | 9 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 446 | 6 | 1 | 4 | 5.3 | O=C(N[C@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL373032 | 135254 | 0 | None | 9 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 446 | 6 | 1 | 4 | 5.3 | O=C(N[C@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C1)c1cccc(-c2cccs2)c1 | 10.1016/j.bmcl.2005.08.051 | ||
11280787 | 108729 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 391 | 9 | 0 | 5 | 3.6 | COCCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL321701 | 108729 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 391 | 9 | 0 | 5 | 3.6 | COCCOc1ccccc1OCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
12899569 | 66291 | 0 | None | -20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 7 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813597 | 66291 | 0 | None | -20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 7 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1852735 | 66291 | 0 | None | -20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 7 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCOc2ccc3ccc(=O)[nH]c3c2)CC1 | 10.1016/j.bmc.2011.04.021 | ||
11375068 | 161309 | 0 | None | -588 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2cccnc2)cc1 | 10.1021/jm049465g | ||
CHEMBL414838 | 161309 | 0 | None | -588 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2cccnc2)cc1 | 10.1021/jm049465g | ||
44578446 | 180998 | 0 | None | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 372 | 6 | 0 | 3 | 4.4 | O=C(CCCN1CC2CC1CN2c1ccc(Cl)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL476934 | 180998 | 0 | None | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 372 | 6 | 0 | 3 | 4.4 | O=C(CCCN1CC2CC1CN2c1ccc(Cl)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
118709164 | 112911 | 0 | None | -87 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 902 | 22 | 0 | 8 | 11.7 | O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318836 | 112911 | 0 | None | -87 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 902 | 22 | 0 | 8 | 11.7 | O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
44335998 | 6387 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 2.9 | O=C1COc2ccccc2N1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL108261 | 6387 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 2.9 | O=C1COc2ccccc2N1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
71657945 | 89964 | 0 | None | -58 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 427 | 10 | 1 | 4 | 3.9 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386608 | 89964 | 0 | None | -58 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 427 | 10 | 1 | 4 | 3.9 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
109030515 | 175412 | 1 | None | 12 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4588808 | 175412 | 1 | None | 12 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 325 | 5 | 1 | 5 | 1.9 | Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
10803828 | 11478 | 1 | None | -2630 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)O[C@@H](CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
CHEMBL1180609 | 11478 | 1 | None | -2630 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)O[C@@H](CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
CHEMBL135044 | 11478 | 1 | None | -2630 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 295 | 2 | 1 | 3 | 3.1 | Oc1ccc2c(c1)O[C@@H](CN1CCc3ccccc3C1)CC2 | 10.1021/jm9703653 | ||
130431340 | 170779 | 0 | None | -851 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 8 | 2 | 4 | 3.3 | CCc1cccc(N2CCN(CCCCNC(=O)c3nc(C)c[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4461461 | 170779 | 0 | None | -851 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 8 | 2 | 4 | 3.3 | CCc1cccc(N2CCN(CCCCNC(=O)c3nc(C)c[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
130431342 | 169017 | 0 | None | -144 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 485 | 9 | 2 | 6 | 4.0 | CCc1cc(Cl)c(OC)c(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4436025 | 169017 | 0 | None | -144 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 485 | 9 | 2 | 6 | 4.0 | CCc1cc(Cl)c(OC)c(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
12050200 | 101620 | 0 | None | 43 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 363 | 6 | 1 | 4 | 4.6 | c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL302186 | 101620 | 0 | None | 43 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 363 | 6 | 1 | 4 | 4.6 | c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/s0960-894x(01)00484-x | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0503805 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0503805 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm0503805 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm049269+ | ||
11772242 | 165734 | 0 | None | 4 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
CHEMBL427048 | 165734 | 0 | None | 4 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1021/jm060279f | ||
49799687 | 14276 | 0 | None | -14 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 3 | 2 | 2 | 4.3 | OC1(c2ccc(I)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173285 | 14276 | 0 | None | -14 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 3 | 2 | 2 | 4.3 | OC1(c2ccc(I)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200269 | 14276 | 0 | None | -14 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 3 | 2 | 2 | 4.3 | OC1(c2ccc(I)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
44340186 | 9569 | 0 | None | 8 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL112831 | 9569 | 0 | None | 8 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(03)00678-4 | ||
11005852 | 202170 | 0 | None | -263 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 521 | 8 | 1 | 4 | 5.9 | O=C(NCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
CHEMBL68720 | 202170 | 0 | None | -263 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 521 | 8 | 1 | 4 | 5.9 | O=C(NCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2=O | 10.1021/jm010146o | ||
72191066 | 91925 | 0 | None | -199 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 406 | 8 | 1 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(N)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
CHEMBL2430440 | 91925 | 0 | None | -199 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 406 | 8 | 1 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc(N)cc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
53248209 | 61662 | 1 | None | -3548 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 463 | 7 | 1 | 4 | 5.0 | O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm200288r | ||
CHEMBL1774386 | 61662 | 1 | None | -3548 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 463 | 7 | 1 | 4 | 5.0 | O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm200288r | ||
4189 | 205195 | 91 | None | -33 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL1559 | 205195 | 91 | None | -33 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL91 | 205195 | 91 | None | -33 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
71061785 | 159949 | 0 | None | -1 | 4 | Mouse | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 386 | 5 | 0 | 4 | 3.0 | O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21 | nan | ||
CHEMBL4112056 | 159949 | 0 | None | -1 | 4 | Mouse | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 386 | 5 | 0 | 4 | 3.0 | O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21 | nan | ||
10039198 | 56055 | 0 | None | -4 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
CHEMBL163087 | 56055 | 0 | None | -4 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
1240 | 8735 | 15 | None | -57 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 6 | 1 | 2 | 4.2 | CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
CHEMBL109684 | 8735 | 15 | None | -57 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 6 | 1 | 2 | 4.2 | CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
CHEMBL1256754 | 8735 | 15 | None | -57 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 6 | 1 | 2 | 4.2 | CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
10403092 | 24928 | 4 | None | -26 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 6 | 1 | 2 | 4.2 | CCCN(CCc1ccccc1)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL134747 | 24928 | 4 | None | -26 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 6 | 1 | 2 | 4.2 | CCCN(CCc1ccccc1)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
145968810 | 164486 | 0 | None | -5 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | ||
CHEMBL4226226 | 164486 | 0 | None | -5 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | ||
44431478 | 87151 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2cccc(Cl)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL233580 | 87151 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 2 | 4.9 | O=C(NC1CCN(Cc2cccc(Cl)c2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
137657153 | 159010 | 0 | None | -4 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4102616 | 159010 | 0 | None | -4 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2003.07.015 | ||
10425450 | 199 | 23 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
3301 | 199 | 23 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL375596 | 199 | 23 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/acs.jmedchem.9b00231 | ||
44393775 | 65972 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 490 | 4 | 1 | 4 | 4.2 | Cc1cc(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)ccc1Br | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184853 | 65972 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 490 | 4 | 1 | 4 | 4.2 | Cc1cc(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)ccc1Br | 10.1016/j.bmcl.2004.07.068 | ||
57393634 | 68977 | 0 | None | -48 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 953 | 32 | 2 | 13 | 6.2 | COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928248 | 68977 | 0 | None | -48 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 953 | 32 | 2 | 13 | 6.2 | COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
127045854 | 139034 | 0 | None | -416 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 492 | 12 | 4 | 7 | 3.6 | COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3797205 | 139034 | 0 | None | -416 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 492 | 12 | 4 | 7 | 3.6 | COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
44337725 | 108051 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 319 | 2 | 0 | 2 | 4.3 | CN1C2CCC1CC(OC1c3ccccc3Cc3ccccc31)C2 | 10.1021/jm010146o | ||
CHEMBL320114 | 108051 | 0 | None | -2 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 319 | 2 | 0 | 2 | 4.3 | CN1C2CCC1CC(OC1c3ccccc3Cc3ccccc31)C2 | 10.1021/jm010146o | ||
22727334 | 12837 | 4 | None | -30 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 4.5 | c1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1189290 | 12837 | 4 | None | -30 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 4.5 | c1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL538474 | 12837 | 4 | None | -30 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 4.5 | c1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
44455426 | 154610 | 0 | None | -7 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
CHEMBL402143 | 154610 | 0 | None | -7 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
10402378 | 65794 | 0 | None | -301 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 297 | 1 | 0 | 3 | 3.2 | COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 | 10.1021/jm049720x | ||
CHEMBL184049 | 65794 | 0 | None | -301 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 297 | 1 | 0 | 3 | 3.2 | COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 | 10.1021/jm049720x | ||
CHEMBL5080654 | 212926 | 0 | None | -8709 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | None | None | None | CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2CCc1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
44336127 | 108793 | 0 | None | 4 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 411 | 5 | 0 | 3 | 4.1 | CC(C)C1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL321871 | 108793 | 0 | None | 4 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 411 | 5 | 0 | 3 | 4.1 | CC(C)C1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
71455083 | 81418 | 0 | None | -239 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 0 | 3 | 4.8 | O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164354 | 81418 | 0 | None | -239 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 0 | 3 | 4.8 | O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
10873318 | 45291 | 0 | None | -12 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 411 | 10 | 1 | 5 | 3.4 | COc1cccc(C(=O)NCCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL152869 | 45291 | 0 | None | -12 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 411 | 10 | 1 | 5 | 3.4 | COc1cccc(C(=O)NCCCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/jm020952a | ||
2407 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 10.1021/jm960345l | ||
59227 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 10.1021/jm960345l | ||
941 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 10.1021/jm960345l | ||
CHEMBL1303 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 10.1021/jm960345l | ||
DB05271 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 10.1021/jm960345l | ||
127047859 | 139521 | 0 | None | -19 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 12 | 3 | 6 | 4.1 | COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3800341 | 139521 | 0 | None | -19 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 12 | 3 | 6 | 4.1 | COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
137635685 | 155464 | 0 | None | -1 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 417 | 7 | 1 | 7 | 3.6 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4061986 | 155464 | 0 | None | -1 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 417 | 7 | 1 | 7 | 3.6 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12 | 10.1021/acs.jmedchem.7b00363 | ||
44326256 | 167573 | 0 | None | -2 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1CCc2c(ccc3ccoc23)[C@@H]1C | 10.1016/S0960-894X(97)10068-3 | ||
CHEMBL433002 | 167573 | 0 | None | -2 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1CCc2c(ccc3ccoc23)[C@@H]1C | 10.1016/S0960-894X(97)10068-3 | ||
44393411 | 65762 | 0 | None | -123 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 587 | 7 | 1 | 4 | 6.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1 | 10.1016/j.bmcl.2004.05.052 | ||
CHEMBL183871 | 65762 | 0 | None | -123 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 587 | 7 | 1 | 4 | 6.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1 | 10.1016/j.bmcl.2004.05.052 | ||
71455082 | 81416 | 0 | None | -15 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 4.7 | O=C(c1cccc2ccccc12)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164352 | 81416 | 0 | None | -15 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 4.7 | O=C(c1cccc2ccccc12)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
11477180 | 3025 | 3 | None | -616 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
6675 | 3025 | 3 | None | -616 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
CHEMBL180010 | 3025 | 3 | None | -616 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 480 | 7 | 1 | 4 | 5.2 | O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
857428 | 31606 | 29 | None | 2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 296 | 4 | 1 | 2 | 4.5 | Cc1cccc2cc(CNCc3ccccc3)c(Cl)nc12 | 10.1021/acs.jmedchem.9b01560 | ||
CHEMBL1406529 | 31606 | 29 | None | 2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 296 | 4 | 1 | 2 | 4.5 | Cc1cccc2cc(CNCc3ccccc3)c(Cl)nc12 | 10.1021/acs.jmedchem.9b01560 | ||
107930 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | ||
3304 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | ||
CHEMBL298406 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | ||
DB12273 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | ||
130431316 | 170114 | 0 | None | -13803 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 454 | 8 | 3 | 4 | 3.7 | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4451683 | 170114 | 0 | None | -13803 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 454 | 8 | 3 | 4 | 3.7 | CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
107930 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | ||
3304 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL298406 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | ||
DB12273 | 1500 | 20 | None | -3090 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | ||
71062560 | 152894 | 0 | None | 1 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 2.4 | O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21 | nan | ||
CHEMBL3979116 | 152894 | 0 | None | 1 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 352 | 5 | 0 | 4 | 2.4 | O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21 | nan | ||
154703541 | 175725 | 1 | None | -23 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 464 | 11 | 1 | 3 | 6.1 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4541924 | 175725 | 1 | None | -23 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 464 | 11 | 1 | 3 | 6.1 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595195 | 175725 | 1 | None | -23 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 464 | 11 | 1 | 3 | 6.1 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
1164 | 1600 | 25 | None | -346 | 11 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
1626 | 1600 | 25 | None | -346 | 11 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
3345 | 1600 | 25 | None | -346 | 11 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
CHEMBL596 | 1600 | 25 | None | -346 | 11 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
DB00813 | 1600 | 25 | None | -346 | 11 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||
9842859 | 203744 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 380 | 6 | 0 | 7 | 2.4 | CN(CCCCN1CCN(c2ncccn2)CC1)C1=Nc2ccccc2OC1 | 10.1016/S0960-894X(97)00442-3 | ||
CHEMBL80411 | 203744 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 380 | 6 | 0 | 7 | 2.4 | CN(CCCCN1CCN(c2ncccn2)CC1)C1=Nc2ccccc2OC1 | 10.1016/S0960-894X(97)00442-3 | ||
1621 | 2396 | 16 | None | -64 | 44 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
17 | 2396 | 16 | None | -64 | 44 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
5761 | 2396 | 16 | None | -64 | 44 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
CHEMBL263881 | 2396 | 16 | None | -64 | 44 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
DB04829 | 2396 | 16 | None | -64 | 44 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
22065962 | 176222 | 0 | None | 20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 294 | 3 | 1 | 5 | 1.7 | c1cnc(N2CCN(Cc3c[nH]c4ncccc34)CC2)nc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL460644 | 176222 | 0 | None | 20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 294 | 3 | 1 | 5 | 1.7 | c1cnc(N2CCN(Cc3c[nH]c4ncccc34)CC2)nc1 | 10.1016/j.bmc.2008.12.054 | ||
132075278 | 162094 | 0 | None | 5 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 3.1 | c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1 | 10.1016/j.ejmech.2018.02.024 | ||
CHEMBL4169752 | 162094 | 0 | None | 5 | 5 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 3.1 | c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1 | 10.1016/j.ejmech.2018.02.024 | ||
11036641 | 31562 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
CHEMBL140612 | 31562 | 0 | None | -1 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 2.3 | COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
71462265 | 81417 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 438 | 6 | 0 | 6 | 3.5 | O=C(c1cnc2ccccc2n1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164353 | 81417 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 438 | 6 | 0 | 6 | 3.5 | O=C(c1cnc2ccccc2n1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
145989012 | 166752 | 0 | None | -95 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 384 | 8 | 2 | 5 | 3.0 | COc1ccc(C(=O)NCCCCN2CCc3cc(OC)c(O)cc3C2)cc1 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4293886 | 166752 | 0 | None | -95 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 384 | 8 | 2 | 5 | 3.0 | COc1ccc(C(=O)NCCCCN2CCc3cc(OC)c(O)cc3C2)cc1 | 10.1021/acsmedchemlett.8b00229 | ||
137654511 | 158257 | 0 | None | -1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 259 | 1 | 2 | 4 | 1.0 | CN1CCN(c2ccc(O)c3[nH]c(=O)ccc23)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4094407 | 158257 | 0 | None | -1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 259 | 1 | 2 | 4 | 1.0 | CN1CCN(c2ccc(O)c3[nH]c(=O)ccc23)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL5075014 | 212583 | 0 | None | -5 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | None | None | None | O=C(NCCCCN1CC[C@]2(c3cccc(O)c3)CCC[C@H]1[C@@H]2O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.1c00611 | ||||
76311271 | 105807 | 0 | None | -371 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 556 | 17 | 2 | 7 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(OCCOCCOCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3133862 | 105807 | 0 | None | -371 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 556 | 17 | 2 | 7 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(OCCOCCOCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
CHEMBL3139046 | 105807 | 0 | None | -371 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 556 | 17 | 2 | 7 | 3.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(OCCOCCOCCF)ccc3[nH]2)CC1 | 10.1039/c3md00098b | ||
11646648 | 93267 | 5 | None | -102 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 382 | 5 | 2 | 4 | 4.4 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(SC)cc4)CC3)c2c1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL247058 | 93267 | 5 | None | -102 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 382 | 5 | 2 | 4 | 4.4 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(SC)cc4)CC3)c2c1 | 10.1016/j.bmcl.2006.10.076 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
763194 | 91711 | 6 | None | 33 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 276 | 3 | 0 | 3 | 3.2 | Fc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420770 | 91711 | 6 | None | 33 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 276 | 3 | 0 | 3 | 3.2 | Fc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
164609519 | 183869 | 0 | None | -47 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4846574 | 183869 | 0 | None | -47 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
25071384 | 111289 | 0 | None | -14 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
CHEMBL3287397 | 111289 | 0 | None | -14 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm501512b | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0611152 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0611152 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0611152 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0611152 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm0611152 | ||
44419060 | 137332 | 0 | None | -13 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 432 | 8 | 1 | 6 | 3.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3o2)CC1 | 10.1021/jm0611152 | ||
CHEMBL376020 | 137332 | 0 | None | -13 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 432 | 8 | 1 | 6 | 3.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3o2)CC1 | 10.1021/jm0611152 | ||
10684789 | 9122 | 1 | None | -89 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1ccncc1)CCN1CC=C(c2ccccc2)CC1 | 10.1021/jm950721m | ||
CHEMBL110489 | 9122 | 1 | None | -89 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1ccncc1)CCN1CC=C(c2ccccc2)CC1 | 10.1021/jm950721m | ||
30438 | 196475 | 30 | None | 9 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 228 | 2 | 1 | 1 | 3.4 | CC1CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1021/jm9600712 | ||
CHEMBL57478 | 196475 | 30 | None | 9 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 228 | 2 | 1 | 1 | 3.4 | CC1CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1021/jm9600712 | ||
30438 | 196475 | 30 | None | 9 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 228 | 2 | 1 | 1 | 3.4 | CC1CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1021/jm0002432 | ||
CHEMBL57478 | 196475 | 30 | None | 9 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 228 | 2 | 1 | 1 | 3.4 | CC1CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1021/jm0002432 | ||
107995 | 96678 | 17 | None | -1380 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 404 | 5 | 2 | 4 | 2.2 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O | 10.1016/j.bmc.2007.07.017 | ||
29982233 | 96678 | 17 | None | -1380 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 404 | 5 | 2 | 4 | 2.2 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL267723 | 96678 | 17 | None | -1380 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 404 | 5 | 2 | 4 | 2.2 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O | 10.1016/j.bmc.2007.07.017 | ||
118709169 | 112917 | 0 | None | -3 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1029 | 31 | 0 | 8 | 15.2 | O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318841 | 112917 | 0 | None | -3 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1029 | 31 | 0 | 8 | 15.2 | O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
10917953 | 206249 | 0 | None | -16595 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 489 | 6 | 0 | 8 | 3.6 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL97242 | 206249 | 0 | None | -16595 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 489 | 6 | 0 | 8 | 3.6 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
134154069 | 153910 | 0 | None | -38 | 9 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3970299 | 153910 | 0 | None | -38 | 9 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990113 | 153910 | 0 | None | -38 | 9 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
44335948 | 167362 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL431437 | 167362 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 3.4 | CC1Cc2ccccc2N1C(=O)CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
154726353 | 175749 | 1 | None | -50 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 467 | 12 | 2 | 3 | 5.9 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4577162 | 175749 | 1 | None | -50 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 467 | 12 | 2 | 3 | 5.9 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595382 | 175749 | 1 | None | -50 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 467 | 12 | 2 | 3 | 5.9 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
154726792 | 176010 | 1 | None | -141 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4475406 | 176010 | 1 | None | -141 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597530 | 176010 | 1 | None | -141 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
10684789 | 9122 | 1 | None | -89 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1ccncc1)CCN1CC=C(c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL110489 | 9122 | 1 | None | -89 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1ccncc1)CCN1CC=C(c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
134154069 | 153910 | 0 | None | -38 | 9 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3970299 | 153910 | 0 | None | -38 | 9 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990113 | 153910 | 0 | None | -38 | 9 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 356 | 5 | 0 | 3 | 5.3 | Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1 | 10.1016/j.bmc.2016.09.019 | ||
164617626 | 184878 | 0 | None | -21 | 7 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 324 | 6 | 1 | 5 | 2.4 | Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4861794 | 184878 | 0 | None | -21 | 7 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 324 | 6 | 1 | 5 | 2.4 | Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
164617626 | 184878 | 0 | None | -21 | 7 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 324 | 6 | 1 | 5 | 2.4 | Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4861794 | 184878 | 0 | None | -21 | 7 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 324 | 6 | 1 | 5 | 2.4 | Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.ejmech.2021.113243 | ||
53324045 | 56776 | 0 | None | -1 | 16 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 7 | 1 | 2 | 7.3 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
CHEMBL1644980 | 56776 | 0 | None | -1 | 16 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 7 | 1 | 2 | 7.3 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
22727332 | 13631 | 0 | None | -5 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 405 | 8 | 0 | 4 | 5.1 | Fc1ccccc1N1CCN(CCCCc2cc(/C=C/c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1195194 | 13631 | 0 | None | -5 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 405 | 8 | 0 | 4 | 5.1 | Fc1ccccc1N1CCN(CCCCc2cc(/C=C/c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL554016 | 13631 | 0 | None | -5 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 405 | 8 | 0 | 4 | 5.1 | Fc1ccccc1N1CCN(CCCCc2cc(/C=C/c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
11615489 | 69100 | 1 | None | -3 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@H]1CCn2nccc2C1 | 10.1021/jm0503805 | ||
CHEMBL193337 | 69100 | 1 | None | -3 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)[C@H]1CCn2nccc2C1 | 10.1021/jm0503805 | ||
11356479 | 71493 | 0 | None | -8 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)C1CCn2nccc2C1 | 10.1021/jm0503805 | ||
CHEMBL196928 | 71493 | 0 | None | -8 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 221 | 5 | 0 | 3 | 2.3 | CCCN(CCC)C1CCn2nccc2C1 | 10.1021/jm0503805 | ||
168287735 | 191208 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5198353 | 191208 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 373 | 5 | 1 | 3 | 4.5 | Fc1cc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)ccc1Cl | 10.1016/j.bmcl.2022.128615 | ||
135995891 | 201271 | 0 | None | 9 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 413 | 4 | 1 | 5 | 4.1 | Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL62996 | 201271 | 0 | None | 9 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 413 | 4 | 1 | 5 | 4.1 | Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
44456400 | 12725 | 0 | None | -21 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
CHEMBL1188501 | 12725 | 0 | None | -21 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
CHEMBL2436555 | 12725 | 0 | None | -21 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
CHEMBL536539 | 12725 | 0 | None | -21 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 181 | 0 | 2 | 3 | 1.4 | NC1=Nc2ccc(Cl)cc2CN1 | 10.1016/j.bmcl.2013.08.072 | ||
16759249 | 9912 | 1 | None | -16 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 7 | 0 | 2 | 5.9 | CCCCN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 | 10.1021/acs.jmedchem.6b01373 | ||
CHEMBL11493 | 9912 | 1 | None | -16 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 7 | 0 | 2 | 5.9 | CCCCN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 | 10.1021/acs.jmedchem.6b01373 | ||
44591087 | 175177 | 0 | None | -1 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 366 | 3 | 1 | 3 | 4.5 | Clc1ccc(N2CCC3CCC(C2)N3Cc2c[nH]c3ncccc23)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL458342 | 175177 | 0 | None | -1 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 366 | 3 | 1 | 3 | 4.5 | Clc1ccc(N2CCC3CCC(C2)N3Cc2c[nH]c3ncccc23)cc1 | 10.1016/j.bmc.2008.12.054 | ||
11464115 | 68292 | 0 | None | -30 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | ||
CHEMBL191815 | 68292 | 0 | None | -30 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | ||
122180576 | 121214 | 0 | None | -107 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 479 | 8 | 0 | 6 | 5.1 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4c(c3)Cc3ccccc3-4)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
CHEMBL3588921 | 121214 | 0 | None | -107 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 479 | 8 | 0 | 6 | 5.1 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccc4c(c3)Cc3ccccc3-4)nn2)CC1 | 10.1016/j.bmc.2015.01.017 | ||
46231925 | 199693 | 0 | None | -3235 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 4.4 | CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL604525 | 199693 | 0 | None | -3235 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 384 | 3 | 1 | 4 | 4.4 | CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | ||
121304441 | 151852 | 0 | None | -11481 | 5 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 515 | 8 | 1 | 6 | 5.0 | Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(C(N)=O)c1 | 10.1021/acs.jmedchem.6b00972 | ||
CHEMBL3970323 | 151852 | 0 | None | -11481 | 5 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 515 | 8 | 1 | 6 | 5.0 | Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(C(N)=O)c1 | 10.1021/acs.jmedchem.6b00972 | ||
CHEMBL5090215 | 213475 | 0 | None | -389 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | None | None | None | CN(C)C(=O)C(CCNCCCCN1CCc2ccc(C#N)cc2C1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
44339984 | 167234 | 0 | None | 10 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL430522 | 167234 | 0 | None | 10 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.9 | COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
44370009 | 49707 | 0 | None | 10 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 263 | 2 | 1 | 2 | 3.1 | c1c[nH]c2nc(CN3CCc4ccccc4C3)cc-2c1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL156896 | 49707 | 0 | None | 10 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 263 | 2 | 1 | 2 | 3.1 | c1c[nH]c2nc(CN3CCc4ccccc4C3)cc-2c1 | 10.1016/s0960-894x(99)00025-6 | ||
3428803 | 100024 | 3 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 3.3 | O=[N+]([O-])c1ccc(OCC(O)CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL29098 | 100024 | 3 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 3.3 | O=[N+]([O-])c1ccc(OCC(O)CN2CCC(Cc3ccccc3)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
44307552 | 101871 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 357 | 5 | 0 | 3 | 3.1 | CN(C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL303692 | 101871 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 357 | 5 | 0 | 3 | 3.1 | CN(C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/s0960-894x(00)00421-2 | ||
44336085 | 5108 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 415 | 4 | 0 | 4 | 4.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCCSc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106007 | 5108 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 415 | 4 | 0 | 4 | 4.0 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCCSc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
9840797 | 15365 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 338 | 3 | 0 | 4 | 3.3 | O=c1ccc2ccc(CN3CCN(c4ccc(F)cc4)CC3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL121884 | 15365 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 338 | 3 | 0 | 4 | 3.3 | O=c1ccc2ccc(CN3CCN(c4ccc(F)cc4)CC3)cc2o1 | 10.1021/jm990266k | ||
127027237 | 138856 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 314 | 6 | 0 | 5 | 2.4 | COc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793264 | 138856 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 314 | 6 | 0 | 5 | 2.4 | COc1ccc(CN2CCO[C@H](COc3cccnc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
137657951 | 159017 | 0 | None | -1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 263 | 1 | 2 | 5 | 0.5 | CN1CCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4102646 | 159017 | 0 | None | -1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 263 | 1 | 2 | 5 | 0.5 | CN1CCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
73353534 | 90627 | 0 | None | -13 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 549 | 18 | 1 | 7 | 5.4 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1 | 10.1021/jm400520c | ||
CHEMBL2397477 | 90627 | 0 | None | -13 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 549 | 18 | 1 | 7 | 5.4 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1 | 10.1021/jm400520c | ||
52937776 | 60842 | 0 | None | -83 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 430 | 10 | 1 | 4 | 4.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1 | 10.1021/jm101639t | ||
CHEMBL1765629 | 60842 | 0 | None | -83 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 430 | 10 | 1 | 4 | 4.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1 | 10.1021/jm101639t | ||
44307552 | 101871 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 357 | 5 | 0 | 3 | 3.1 | CN(C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL303692 | 101871 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 357 | 5 | 0 | 3 | 3.1 | CN(C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/acs.jmedchem.7b00151 | ||
42606573 | 17664 | 0 | None | 20 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 381 | 5 | 1 | 4 | 3.9 | Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1 | 10.1021/jm100835q | ||
CHEMBL1258999 | 17664 | 0 | None | 20 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 381 | 5 | 1 | 4 | 3.9 | Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1 | 10.1021/jm100835q | ||
12050196 | 201428 | 5 | None | 8 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 349 | 5 | 0 | 4 | 4.1 | c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64043 | 201428 | 5 | None | 8 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 349 | 5 | 0 | 4 | 4.1 | c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1 | 10.1016/s0960-894x(00)00405-4 | ||
12050193 | 201506 | 0 | None | -1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 4.9 | COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64325 | 201506 | 0 | None | -1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 443 | 5 | 0 | 5 | 4.9 | COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1 | 10.1016/s0960-894x(00)00405-4 | ||
46231846 | 199654 | 0 | None | -2344 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 341 | 1 | 1 | 3 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL604316 | 199654 | 0 | None | -2344 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 341 | 1 | 1 | 3 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
10735463 | 161328 | 0 | None | 239 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 5 | 2.5 | Cc1[nH]c(-c2ccccc2)nc1CN1CCN(c2ncccn2)CC1 | 10.1021/jm960637m | ||
CHEMBL415014 | 161328 | 0 | None | 239 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 5 | 2.5 | Cc1[nH]c(-c2ccccc2)nc1CN1CCN(c2ncccn2)CC1 | 10.1021/jm960637m | ||
44335877 | 4791 | 0 | None | 426 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 419 | 4 | 0 | 3 | 3.7 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(F)c(Cl)cc2F)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL104323 | 4791 | 0 | None | 426 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 419 | 4 | 0 | 3 | 3.7 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(F)c(Cl)cc2F)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44336027 | 5037 | 0 | None | 165 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL105601 | 5037 | 0 | None | 165 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44335960 | 6450 | 0 | None | 31 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL108282 | 6450 | 0 | None | 31 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44336108 | 5608 | 0 | None | 85 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 3.8 | CCC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107793 | 5608 | 0 | None | 85 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 3.8 | CCC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335923 | 108706 | 0 | None | 125 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 377 | 5 | 0 | 3 | 3.3 | CCc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL321538 | 108706 | 0 | None | 125 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 377 | 5 | 0 | 3 | 3.3 | CCc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)cc1 | 10.1016/s0960-894x(02)00655-8 | ||
44335884 | 162825 | 0 | None | 11 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 366 | 4 | 0 | 2 | 4.4 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL419356 | 162825 | 0 | None | 11 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 366 | 4 | 0 | 2 | 4.4 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335799 | 162902 | 0 | None | 102 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 5 | 0 | 4 | 3.7 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2cccc(OC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL419908 | 162902 | 0 | None | 102 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 5 | 0 | 4 | 3.7 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2cccc(OC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm100899z | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm100899z | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm100899z | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm100899z | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm100899z | ||
25071691 | 111295 | 0 | None | -9 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
CHEMBL3287403 | 111295 | 0 | None | -9 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12 | 10.1021/jm5004039 | ||
CHEMBL4547253 | 212243 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | None | None | None | Fc1ccc(CN2CCC(n3cc(Cc4ccc(Br)cc4)nn3)CC2)cc1 | 10.1016/j.bmc.2022.116851 | ||||
CHEMBL4567314 | 212262 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | None | None | None | Brc1ccc(Cc2cn(C3CCN(Cc4ccccc4)CC3)nn2)cc1 | 10.1016/j.bmc.2022.116851 | ||||
71459761 | 83666 | 0 | None | 14 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 7 | 0 | 5 | 6.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207642 | 83666 | 0 | None | 14 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 7 | 0 | 5 | 6.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
10570563 | 17846 | 0 | None | 15 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL1202212 | 17846 | 0 | None | 15 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL126429 | 17846 | 0 | None | 15 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 360 | 4 | 0 | 2 | 4.9 | Clc1ccc(N2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)cc1Cl | 10.1021/acs.jmedchem.7b00151 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0611152 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0611152 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0611152 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0611152 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0611152 | ||
9836900 | 41458 | 1 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 323 | 3 | 1 | 4 | 2.3 | O=C1COc2cc(CN3CCN(c4ccccc4)CC3)ccc2N1 | 10.1021/jm990277d | ||
CHEMBL149233 | 41458 | 1 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 323 | 3 | 1 | 4 | 2.3 | O=C1COc2cc(CN3CCN(c4ccccc4)CC3)ccc2N1 | 10.1021/jm990277d | ||
44336012 | 108727 | 0 | None | 120 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL321698 | 108727 | 0 | None | 120 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
90644058 | 111537 | 0 | None | 104 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 372 | 4 | 0 | 3 | 4.0 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289642 | 111537 | 0 | None | 104 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 372 | 4 | 0 | 3 | 4.0 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
54585811 | 61281 | 0 | None | -4 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771113 | 61281 | 0 | None | -4 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 0 | 5 | 3.2 | COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
90644058 | 111537 | 0 | None | 104 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 372 | 4 | 0 | 3 | 4.0 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289642 | 111537 | 0 | None | 104 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 372 | 4 | 0 | 3 | 4.0 | O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2014.04.026 | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm9810396 | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm9810396 | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm9810396 | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm9810396 | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm9810396 | ||
72164302 | 91729 | 0 | None | 19 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 359 | 3 | 1 | 2 | 4.8 | Clc1cccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420895 | 91729 | 0 | None | 19 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 359 | 3 | 1 | 2 | 4.8 | Clc1cccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | ||
155562328 | 175270 | 0 | None | 7 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1ccc(N(Cc2cccc(F)c2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4585384 | 175270 | 0 | None | 7 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 521 | 11 | 2 | 6 | 4.3 | COc1ccc(N(Cc2cccc(F)c2)NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
57393083 | 69824 | 0 | None | 1 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 314 | 6 | 0 | 4 | 2.8 | Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940415 | 69824 | 0 | None | 1 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 314 | 6 | 0 | 4 | 2.8 | Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57393083 | 69824 | 0 | None | 1 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 314 | 6 | 0 | 4 | 2.8 | Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940415 | 69824 | 0 | None | 1 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 314 | 6 | 0 | 4 | 2.8 | Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm800895v | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm800895v | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm800895v | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm800895v | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm800895v | ||
19964401 | 156105 | 0 | None | 208 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 320 | 5 | 1 | 2 | 4.0 | c1ccc(CCC2CN(Cc3c[nH]c4ccccc34)CCO2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL4069306 | 156105 | 0 | None | 208 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 320 | 5 | 1 | 2 | 4.0 | c1ccc(CCC2CN(Cc3c[nH]c4ccccc34)CCO2)cc1 | 10.1021/acs.jmedchem.7b00151 | ||
11849778 | 80730 | 0 | None | 35 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
CHEMBL215705 | 80730 | 0 | None | 35 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 360 | 6 | 0 | 5 | 2.9 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cc(F)cc(F)c1 | 10.1021/jm060279f | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2004859 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2004859 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2004859 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2004859 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2004859 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2009919 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2009919 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2009919 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2009919 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm2009919 | ||
9817253 | 106073 | 0 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 283 | 6 | 3 | 4 | 2.4 | Oc1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL314174 | 106073 | 0 | None | -6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 283 | 6 | 3 | 4 | 2.4 | Oc1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
10249755 | 167621 | 0 | None | 1258 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 5.1 | COc1cc2ccccc2cc1OC(=O)CC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
CHEMBL433255 | 167621 | 0 | None | 1258 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 5.1 | COc1cc2ccccc2cc1OC(=O)CC1CCN(Cc2ccccc2)CC1 | 10.1021/jm960017l | ||
15443 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL340211 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
15443 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL340211 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113243 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
11336814 | 79691 | 0 | None | 7 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
CHEMBL213164 | 79691 | 0 | None | 7 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 6 | 0 | 5 | 2.8 | CO/N=C(/CCN1CCN(c2ccccn2)CC1)c1cccc(F)c1 | 10.1021/jm060279f | ||
11200205 | 138382 | 0 | None | 9 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL378324 | 138382 | 0 | None | 9 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 4.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm060279f | ||
53363200 | 63522 | 0 | None | 2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 14 | 0 | 9 | 3.7 | CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803052 | 63522 | 0 | None | 2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 14 | 0 | 9 | 3.7 | CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
16121920 | 194202 | 0 | None | 426 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 380 | 5 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL558838 | 194202 | 0 | None | 426 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 380 | 5 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
45267435 | 194317 | 0 | None | 426 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL559868 | 194317 | 0 | None | 426 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12 | 10.1016/j.bmc.2009.05.015 | ||
10088259 | 101443 | 3 | None | 134 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL300956 | 101443 | 3 | None | 134 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
71458040 | 78477 | 0 | None | 27 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 329 | 5 | 1 | 2 | 4.5 | C1=C(/C=C/c2ccccc2)CCN(CCc2c[nH]c3ncccc23)C1 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL2112913 | 78477 | 0 | None | 27 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 329 | 5 | 1 | 2 | 4.5 | C1=C(/C=C/c2ccccc2)CCN(CCc2c[nH]c3ncccc23)C1 | 10.1016/s0960-894x(99)00025-6 | ||
10088259 | 101443 | 3 | None | 134 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1021/jm970021c | ||
CHEMBL300956 | 101443 | 3 | None | 134 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | Cc1ccc(C(=O)NCN2CCN(c3ccccc3C#N)CC2)cc1 | 10.1021/jm970021c | ||
155561496 | 175099 | 0 | None | -5 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 438 | 8 | 0 | 6 | 3.1 | COc1cc2c(cc1OC)C(=O)N(CCCCN1CCN(c3ccccn3)CC1)CCC2 | 10.1021/acs.jmedchem.8b00760 | ||
CHEMBL4581645 | 175099 | 0 | None | -5 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 438 | 8 | 0 | 6 | 3.1 | COc1cc2c(cc1OC)C(=O)N(CCCCN1CCN(c3ccccn3)CC1)CCC2 | 10.1021/acs.jmedchem.8b00760 | ||
10065083 | 31887 | 1 | None | -1 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL140872 | 31887 | 1 | None | -1 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.12.019 | ||
137638973 | 156332 | 0 | None | -15 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 436 | 10 | 2 | 7 | 4.3 | CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4071868 | 156332 | 0 | None | -15 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 436 | 10 | 2 | 7 | 4.3 | CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
10065083 | 31887 | 1 | None | 1 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL140872 | 31887 | 1 | None | 1 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
11653679 | 180609 | 1 | None | 3 | 11 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL476108 | 180609 | 1 | None | 3 | 11 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
168273039 | 192194 | 0 | None | 1659 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5175009 | 192194 | 0 | None | 1659 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221414 | 192194 | 0 | None | 1659 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 3.1 | O=C1CCc2ccccc2N1CCCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
10498196 | 41738 | 0 | None | 63 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 4 | 1 | 4 | 3.4 | COc1ccc(C2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
CHEMBL149497 | 41738 | 0 | None | 63 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 4 | 1 | 4 | 3.4 | COc1ccc(C2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1 | 10.1021/jm990277d | ||
10382581 | 100828 | 0 | None | 151 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm970021c | ||
CHEMBL296506 | 100828 | 0 | None | 151 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1021/jm970021c | ||
15443 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL340211 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2020.115943 | ||
15443 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL340211 | 117307 | 91 | None | 1 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.0 | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113243 | ||
44278114 | 99742 | 0 | None | 104 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.8 | CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
CHEMBL28833 | 99742 | 0 | None | 104 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.8 | CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/s0960-894x(01)00241-4 | ||
10382581 | 100828 | 0 | None | 151 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL296506 | 100828 | 0 | None | 151 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2cccc(C)c2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
133079 | 3581 | 33 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/jm0002432 | ||
980 | 3581 | 33 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/jm0002432 | ||
CHEMBL69759 | 3581 | 33 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/jm0002432 | ||
11465618 | 101926 | 18 | None | -25 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | ||
CHEMBL3039528 | 101926 | 18 | None | -25 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | ||
CHEMBL5191141 | 101926 | 18 | None | -25 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | ||
53364225 | 63514 | 0 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 932 | 25 | 0 | 18 | 5.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803027 | 63514 | 0 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 932 | 25 | 0 | 18 | 5.4 | COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2004859 | ||
10336538 | 1595 | 44 | None | -3 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm900690y | ||
974 | 1595 | 44 | None | -3 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm900690y | ||
CHEMBL310843 | 1595 | 44 | None | -3 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 10.1021/jm900690y | ||
155562395 | 175375 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4587925 | 175375 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.5 | Cc1ccc(C2CCN(CC(=O)Nc3cccc(C)c3)CC2)nc1 | 10.1021/acs.jmedchem.9b00231 | ||
9946469 | 43872 | 0 | None | 11 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 351 | 3 | 1 | 4 | 3.0 | Cc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1C | 10.1021/jm990277d | ||
CHEMBL151533 | 43872 | 0 | None | 11 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 351 | 3 | 1 | 4 | 3.0 | Cc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1C | 10.1021/jm990277d | ||
9907332 | 16219 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 368 | 3 | 0 | 4 | 4.1 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1Cl | 10.1021/jm990266k | ||
CHEMBL123031 | 16219 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 368 | 3 | 0 | 4 | 4.1 | Cc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1Cl | 10.1021/jm990266k | ||
57391307 | 69820 | 0 | None | 8 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.1 | Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940411 | 69820 | 0 | None | 8 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.1 | Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57391307 | 69820 | 0 | None | 8 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.1 | Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940411 | 69820 | 0 | None | 8 | 7 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.1 | Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
168277064 | 192236 | 0 | None | 1202 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5178868 | 192236 | 0 | None | 1202 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221670 | 192236 | 0 | None | 1202 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 3.2 | COc1ccc(N2CCN(CCCN3C(=O)CCc4ccccc43)CC2)cc1 | 10.1021/acs.jmedchem.2c00840 | ||
10786367 | 203465 | 0 | None | 9 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(-c2cc(C3CCN(Cc4cccc(Cl)c4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL78287 | 203465 | 0 | None | 9 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(-c2cc(C3CCN(Cc4cccc(Cl)c4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
10018480 | 13718 | 0 | None | -1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 0 | 1 | 5.0 | C=CCN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL1195797 | 13718 | 0 | None | -1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 0 | 1 | 5.0 | C=CCN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL555362 | 13718 | 0 | None | -1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 0 | 1 | 5.0 | C=CCN1CC=C(C2=Cc3ccccc3Cc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2012.08.011 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2012.08.011 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2012.08.011 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2012.08.011 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2012.08.011 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.05.027 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.05.027 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.05.027 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2013.05.027 | ||
137636066 | 155692 | 0 | None | -38 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 480 | 7 | 3 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4064742 | 155692 | 0 | None | -38 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 480 | 7 | 3 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
71733932 | 90621 | 0 | None | -25 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm501889t | ||
CHEMBL2397389 | 90621 | 0 | None | -25 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm501889t | ||
13457126 | 99362 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 392 | 6 | 1 | 4 | 3.9 | O=C(CCN1CCN(c2ccc(CO)c(Cl)c2)CC1)c1ccc(Cl)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL285543 | 99362 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 392 | 6 | 1 | 4 | 3.9 | O=C(CCN1CCN(c2ccc(CO)c(Cl)c2)CC1)c1ccc(Cl)cc1 | 10.1016/s0960-894x(98)00252-2 | ||
69432471 | 109358 | 0 | None | -60 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 378 | 5 | 0 | 3 | 4.4 | O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCC3)c1ccc(F)cc1 | 10.1021/jm401958n | ||
CHEMBL3233427 | 109358 | 0 | None | -60 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 378 | 5 | 0 | 3 | 4.4 | O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCC3)c1ccc(F)cc1 | 10.1021/jm401958n | ||
17755867 | 85682 | 1 | None | -28 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | ||
CHEMBL231070 | 85682 | 1 | None | -28 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | ||
46912547 | 14277 | 0 | None | -67 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 4 | 2 | 3 | 4.3 | COc1cccc2[nH]cc(CN3CCC(O)(c4ccc(I)cc4)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173287 | 14277 | 0 | None | -67 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 4 | 2 | 3 | 4.3 | COc1cccc2[nH]cc(CN3CCC(O)(c4ccc(I)cc4)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200270 | 14277 | 0 | None | -67 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 4 | 2 | 3 | 4.3 | COc1cccc2[nH]cc(CN3CCC(O)(c4ccc(I)cc4)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
164628178 | 185765 | 0 | None | -46 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 4.4 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4875081 | 185765 | 0 | None | -46 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 4.4 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
10007017 | 82615 | 0 | None | -812 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 7 | 2 | 3 | 5.6 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(Br)ccc2[nH]1 | 10.1021/jm0611152 | ||
CHEMBL218150 | 82615 | 0 | None | -812 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 7 | 2 | 3 | 5.6 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(Br)ccc2[nH]1 | 10.1021/jm0611152 | ||
12581154 | 25275 | 10 | None | -4 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 191 | 2 | 1 | 2 | 1.8 | CNC1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
CHEMBL135048 | 25275 | 10 | None | -4 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 191 | 2 | 1 | 2 | 1.8 | CNC1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
10184153 | 13193 | 0 | None | -15 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 10 | 0 | 4 | 6.6 | C(=C/c1cc(CCCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)on1)\c1ccccc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191883 | 13193 | 0 | None | -15 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 10 | 0 | 4 | 6.6 | C(=C/c1cc(CCCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)on1)\c1ccccc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL543041 | 13193 | 0 | None | -15 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 10 | 0 | 4 | 6.6 | C(=C/c1cc(CCCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)on1)\c1ccccc1 | 10.1016/s0960-894x(02)00179-8 | ||
10994141 | 44670 | 0 | None | -831 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 456 | 7 | 1 | 4 | 4.9 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccnc2ccccc12 | 10.1021/jm020952a | ||
CHEMBL152304 | 44670 | 0 | None | -831 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 456 | 7 | 1 | 4 | 4.9 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccnc2ccccc12 | 10.1021/jm020952a | ||
164628178 | 185765 | 0 | None | -46 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 4.4 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
CHEMBL4875081 | 185765 | 0 | None | -46 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 4.4 | COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1 | 10.1021/acs.jmedchem.1c01327 | ||
71657942 | 89961 | 0 | None | -154 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 424 | 9 | 1 | 5 | 3.5 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386605 | 89961 | 0 | None | -154 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 424 | 9 | 1 | 5 | 3.5 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
168268877 | 189377 | 0 | None | -134 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | ||
CHEMBL5170784 | 189377 | 0 | None | -134 | 12 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | ||
44438204 | 93223 | 2 | None | -48 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 324 | 3 | 2 | 2 | 3.8 | OC1(c2ccc(F)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246849 | 93223 | 2 | None | -48 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 324 | 3 | 2 | 2 | 3.8 | OC1(c2ccc(F)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
10786591 | 205002 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 389 | 3 | 0 | 4 | 4.7 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(Cl)c(Cl)c1)CC3 | 10.1021/jm970170v | ||
CHEMBL89913 | 205002 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 389 | 3 | 0 | 4 | 4.7 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(Cl)c(Cl)c1)CC3 | 10.1021/jm970170v | ||
3746693 | 200715 | 12 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL61080 | 200715 | 12 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)[nH]n3)CC2)cc1 | 10.1021/jm970111h | ||
3746693 | 200715 | 12 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)[nH]n3)CC2)cc1 | 10.1021/jm0002432 | ||
CHEMBL61080 | 200715 | 12 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)[nH]n3)CC2)cc1 | 10.1021/jm0002432 | ||
155538028 | 171793 | 0 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 453 | 11 | 2 | 6 | 3.1 | C=CCN(NC(=O)NCCCN1CCN(c2ccccc2OC)CC1)c1ccc(OC)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4475978 | 171793 | 0 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 453 | 11 | 2 | 6 | 3.1 | C=CCN(NC(=O)NCCCN1CCN(c2ccccc2OC)CC1)c1ccc(OC)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
49782603 | 17307 | 0 | None | -2 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 6 | 1 | 3 | 4.9 | Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm100899z | ||
CHEMBL1257811 | 17307 | 0 | None | -2 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 6 | 1 | 3 | 4.9 | Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1 | 10.1021/jm100899z | ||
3746693 | 200715 | 12 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)[nH]n3)CC2)cc1 | 10.1021/jm960072u | ||
CHEMBL61080 | 200715 | 12 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 5.8 | Clc1ccc(CN2CCC(c3cc(-c4ccc(Cl)cc4)[nH]n3)CC2)cc1 | 10.1021/jm960072u | ||
11187628 | 4803 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 6 | 0 | 4 | 4.3 | COc1ccccc1SCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL104378 | 4803 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 6 | 0 | 4 | 4.3 | COc1ccccc1SCC1CN(Cc2ccc(Cl)cc2)CCO1 | 10.1021/jm031111m | ||
11164922 | 5306 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.0 | COc1ccccc1OCC1CN(Cc2ccc(C(F)(F)F)cc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL107019 | 5306 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 381 | 6 | 0 | 4 | 4.0 | COc1ccccc1OCC1CN(Cc2ccc(C(F)(F)F)cc2)CCO1 | 10.1021/jm031111m | ||
9925730 | 204575 | 0 | None | -5 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 281 | 6 | 2 | 3 | 3.0 | Cc1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL87067 | 204575 | 0 | None | -5 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 281 | 6 | 2 | 3 | 3.0 | Cc1nc2c(OCCNCc3ccccc3)cccc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
178078 | 120604 | 3 | None | -117 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 345 | 4 | 1 | 2 | 5.4 | Oc1ccc(C2=CCC[C@@H](CN3CC=C(c4ccccc4)CC3)C2)cc1 | 10.1021/jm00026a007 | ||
CHEMBL357416 | 120604 | 3 | None | -117 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 345 | 4 | 1 | 2 | 5.4 | Oc1ccc(C2=CCC[C@@H](CN3CC=C(c4ccccc4)CC3)C2)cc1 | 10.1021/jm00026a007 | ||
8704110 | 66268 | 9 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 2.9 | Cc1cccc(NC(=O)CN2CCN(c3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL185263 | 66268 | 9 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 2.9 | Cc1cccc(NC(=O)CN2CCN(c3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
44340302 | 9660 | 0 | None | 1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 466 | 7 | 1 | 3 | 5.3 | COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL113471 | 9660 | 0 | None | 1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 466 | 7 | 1 | 3 | 5.3 | COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
25139331 | 169361 | 0 | None | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 310 | 9 | 2 | 2 | 3.9 | CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800895v | ||
CHEMBL444128 | 169361 | 0 | None | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 310 | 9 | 2 | 2 | 3.9 | CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1 | 10.1021/jm800895v | ||
137636298 | 155657 | 0 | None | -3 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 245 | 1 | 3 | 4 | 0.6 | O=c1ccc2c(N3CCNCC3)ccc(O)c2[nH]1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4064191 | 155657 | 0 | None | -3 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 245 | 1 | 3 | 4 | 0.6 | O=c1ccc2c(N3CCNCC3)ccc(O)c2[nH]1 | 10.1016/j.bmc.2017.08.037 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
137643122 | 157491 | 0 | None | -17 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 8 | 2 | 10 | 2.6 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4085752 | 157491 | 0 | None | -17 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 8 | 2 | 10 | 2.6 | O/N=C/c1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | ||
10642106 | 38986 | 2 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.0 | O=C1COc2ccc(CN3CCN(c4ccc(Cl)cc4)CC3)cc2N1 | 10.1021/jm990277d | ||
CHEMBL147011 | 38986 | 2 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.0 | O=C1COc2ccc(CN3CCN(c4ccc(Cl)cc4)CC3)cc2N1 | 10.1021/jm990277d | ||
49799715 | 14218 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 3 | 2 | 3 | 3.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1170879 | 14218 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 3 | 2 | 3 | 3.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200020 | 14218 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 3 | 2 | 3 | 3.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
44374648 | 119467 | 0 | None | -3 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 5 | 1 | 4 | 3.3 | CCCN[C@@H]1CCc2c(OS(=O)(=O)C(F)(F)F)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
CHEMBL349843 | 119467 | 0 | None | -3 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 5 | 1 | 4 | 3.3 | CCCN[C@@H]1CCc2c(OS(=O)(=O)C(F)(F)F)cccc2[C@@H]1C | 10.1016/S0960-894X(01)80181-5 | ||
176 | 394 | 63 | None | -4 | 31 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
2157 | 394 | 63 | None | -4 | 31 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
2566 | 394 | 63 | None | -4 | 31 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
CHEMBL633 | 394 | 63 | None | -4 | 31 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
DB01118 | 394 | 63 | None | -4 | 31 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
44336105 | 4867 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 425 | 6 | 0 | 3 | 4.5 | CC(C)CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104713 | 4867 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 425 | 6 | 0 | 3 | 4.5 | CC(C)CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
155195486 | 169120 | 0 | None | -14 | 3 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@@H]1C[C@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4437740 | 169120 | 0 | None | -14 | 3 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@@H]1C[C@H]1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
46231847 | 198890 | 0 | None | -3162 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 343 | 1 | 2 | 3 | 3.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL599116 | 198890 | 0 | None | -3162 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 343 | 1 | 2 | 3 | 3.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
10544707 | 16125 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccccc1N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1 | 10.1021/jm990266k | ||
CHEMBL122531 | 16125 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1ccccc1N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1 | 10.1021/jm990266k | ||
44426509 | 85316 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 372 | 6 | 1 | 2 | 4.7 | O=C(NC1CCN(CCCc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL229024 | 85316 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 372 | 6 | 1 | 2 | 4.7 | O=C(NC1CCN(CCCc2ccccc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.096 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
10357869 | 4815 | 0 | None | 6 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 307 | 4 | 0 | 4 | 4.0 | c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL104453 | 4815 | 0 | None | 6 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 307 | 4 | 0 | 4 | 4.0 | c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1 | 10.1016/s0960-894x(99)00540-5 | ||
44273920 | 73576 | 0 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 377 | 5 | 1 | 3 | 3.7 | CC(C)(C)C(=O)NCCCCN1CCN2c3ccc(Cl)cc3CCC2C1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20204 | 73576 | 0 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 377 | 5 | 1 | 3 | 3.7 | CC(C)(C)C(=O)NCCCCN1CCN2c3ccc(Cl)cc3CCC2C1 | 10.1016/0960-894X(96)00198-9 | ||
44273921 | 77009 | 0 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 365 | 6 | 1 | 3 | 3.8 | CC1CN(CCCCNC(=O)C(C)(C)C)CCN1c1ccc(Cl)cc1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20854 | 77009 | 0 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 365 | 6 | 1 | 3 | 3.8 | CC1CN(CCCCNC(=O)C(C)(C)C)CCN1c1ccc(Cl)cc1 | 10.1016/0960-894X(96)00198-9 | ||
4302960 | 100592 | 57 | None | -199 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1 | 10.1016/0960-894X(95)00011-H | ||
CHEMBL294747 | 100592 | 57 | None | -199 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1 | 10.1016/0960-894X(95)00011-H | ||
168268735 | 192167 | 0 | None | 16 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 4 | 0 | 3 | 2.8 | O=C1CCc2ccccc2N1CCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5171721 | 192167 | 0 | None | 16 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 4 | 0 | 3 | 2.8 | O=C1CCc2ccccc2N1CCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5221227 | 192167 | 0 | None | 16 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 4 | 0 | 3 | 2.8 | O=C1CCc2ccccc2N1CCN1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.2c00840 | ||
CHEMBL5092243 | 213580 | 0 | None | 1 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | None | None | None | CCc1cccc(N2CCN(CCC(c3cccc(OC)c3)c3cccc(OC)c3)CC2)c1Cl | 10.1021/acs.jmedchem.1c00611 | ||||
10430816 | 167684 | 1 | None | -371 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 3.6 | COc1cccc(C(=O)NCCCCN2CCN(c3cccc(C)c3C)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL433741 | 167684 | 1 | None | -371 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 3.6 | COc1cccc(C(=O)NCCCCN2CCN(c3cccc(C)c3C)CC2)c1 | 10.1021/jm020952a | ||
49788868 | 18039 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 2.1 | COc1cccc(C(=O)NCCN2CCN(c3ccc(C#N)cc3)CC2)c1 | 10.1021/jm100925m | ||
CHEMBL1270120 | 18039 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 2.1 | COc1cccc(C(=O)NCCN2CCN(c3ccc(C#N)cc3)CC2)c1 | 10.1021/jm100925m | ||
44437896 | 151936 | 0 | None | -57 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 400 | 6 | 1 | 3 | 2.7 | C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC | 10.1016/j.bmc.2007.07.017 | ||
CHEMBL397103 | 151936 | 0 | None | -57 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 400 | 6 | 1 | 3 | 2.7 | C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC | 10.1016/j.bmc.2007.07.017 | ||
10479822 | 82616 | 0 | None | -1778 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 7 | 2 | 4 | 4.7 | N#Cc1ccc2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)[nH]c2c1 | 10.1021/jm0611152 | ||
CHEMBL218151 | 82616 | 0 | None | -1778 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 7 | 2 | 4 | 4.7 | N#Cc1ccc2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)[nH]c2c1 | 10.1021/jm0611152 | ||
90389439 | 145166 | 0 | None | -14 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 3.8 | CC(O)CN1CCN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL3916231 | 145166 | 0 | None | -14 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 3.8 | CC(O)CN1CCN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
90389439 | 145166 | 0 | None | -14 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 3.8 | CC(O)CN1CCN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.6b01373 | ||
CHEMBL3916231 | 145166 | 0 | None | -14 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 3.8 | CC(O)CN1CCN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.6b01373 | ||
52937871 | 60844 | 0 | None | -162 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 458 | 11 | 1 | 5 | 4.6 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1 | 10.1021/jm101639t | ||
CHEMBL1765631 | 60844 | 0 | None | -162 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 458 | 11 | 1 | 5 | 4.6 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1 | 10.1021/jm101639t | ||
12280575 | 10190 | 2 | None | -6 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)C1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
CHEMBL11615 | 10190 | 2 | None | -6 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 261 | 6 | 0 | 2 | 3.7 | CCCN(CCC)C1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
49798797 | 14241 | 0 | None | -10 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 433 | 3 | 2 | 3 | 3.7 | OC1(c2ccc(I)cc2)CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1172208 | 14241 | 0 | None | -10 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 433 | 3 | 2 | 3 | 3.7 | OC1(c2ccc(I)cc2)CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200149 | 14241 | 0 | None | -10 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 433 | 3 | 2 | 3 | 3.7 | OC1(c2ccc(I)cc2)CCN(Cc2c[nH]c3ncccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
3038495 | 700 | 30 | None | -91 | 19 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/acs.jmedchem.9b01835 | ||
7625 | 700 | 30 | None | -91 | 19 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL25236 | 700 | 30 | None | -91 | 19 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/acs.jmedchem.9b01835 | ||
72190766 | 91928 | 0 | None | -12 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 391 | 8 | 0 | 6 | 3.6 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccccc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
CHEMBL2430443 | 91928 | 0 | None | -12 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 391 | 8 | 0 | 6 | 3.6 | COc1ccccc1N1CCN(CCCCn2cc(-c3ccccc3)nn2)CC1 | 10.1016/j.bmcl.2013.08.047 | ||
44336175 | 107711 | 0 | None | -13 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 399 | 5 | 0 | 4 | 3.1 | COc1cccc2c1CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL319650 | 107711 | 0 | None | -13 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 399 | 5 | 0 | 4 | 3.1 | COc1cccc2c1CCN2C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44339879 | 171716 | 0 | None | 4 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL447476 | 171716 | 0 | None | 4 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
10871118 | 205080 | 0 | None | 186 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1 | 10.1021/jm015522j | ||
CHEMBL90374 | 205080 | 0 | None | 186 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1 | 10.1021/jm015522j | ||
44335847 | 4992 | 0 | None | 36 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL105354 | 4992 | 0 | None | 36 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
155536022 | 171537 | 0 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 11 | 2 | 6 | 3.5 | C=C(C)CN(NC(=O)NCCCN1CCN(c2ccccc2OC)CC1)c1ccc(OC)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4472580 | 171537 | 0 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 11 | 2 | 6 | 3.5 | C=C(C)CN(NC(=O)NCCCN1CCN(c2ccccc2OC)CC1)c1ccc(OC)cc1 | 10.1021/acs.jmedchem.9b01085 | ||
164614709 | 184626 | 0 | None | -15 | 7 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 383 | 6 | 0 | 4 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4857665 | 184626 | 0 | None | -15 | 7 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 383 | 6 | 0 | 4 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
57400556 | 68968 | 0 | None | -97 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 495 | 13 | 1 | 8 | 3.1 | CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928134 | 68968 | 0 | None | -97 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 495 | 13 | 1 | 8 | 3.1 | CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
56589560 | 70253 | 0 | None | -14 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C | 10.1021/jm200676f | ||
CHEMBL1949725 | 70253 | 0 | None | -14 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C | 10.1021/jm200676f | ||
164614709 | 184626 | 0 | None | -15 | 7 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 383 | 6 | 0 | 4 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4857665 | 184626 | 0 | None | -15 | 7 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 383 | 6 | 0 | 4 | 4.1 | O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
164621610 | 185609 | 0 | None | -4 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4872800 | 185609 | 0 | None | -4 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL5088070 | 213362 | 0 | None | -75 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | None | None | None | CCc1cccc(N2CCN(CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1Cl | 10.1021/acs.jmedchem.1c00611 | ||||
24810004 | 16373 | 0 | None | -10 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 419 | 6 | 0 | 2 | 6.3 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2ccccc2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
CHEMBL12375 | 16373 | 0 | None | -10 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 419 | 6 | 0 | 2 | 6.3 | Fc1ccc(C(OC2CC3CCC(C2)N3Cc2ccccc2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
42626103 | 55960 | 0 | None | -1479 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 4.6 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
CHEMBL1627323 | 55960 | 0 | None | -1479 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 4.6 | O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1 | 10.1021/jm900095y | ||
168274755 | 190048 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1cnc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5181334 | 190048 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 403 | 5 | 0 | 4 | 4.8 | Cn1cnc2cc(CN3CCC(OCc4cccc(C(F)(F)F)c4)CC3)ccc21 | 10.1016/j.bmcl.2022.128615 | ||
10039198 | 56055 | 0 | None | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
CHEMBL163087 | 56055 | 0 | None | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 277 | 5 | 0 | 1 | 4.5 | CCCN(CCC)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm991098z | ||
11049209 | 205672 | 0 | None | -13182 | 9 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL93923 | 205672 | 0 | None | -13182 | 9 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 486 | 6 | 1 | 5 | 4.4 | Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
11658914 | 69897 | 0 | None | -30 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 255 | 5 | 0 | 3 | 3.0 | CCCN(CCC)C1CCn2ncc(Cl)c2C1 | 10.1021/jm0503805 | ||
CHEMBL194099 | 69897 | 0 | None | -30 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 255 | 5 | 0 | 3 | 3.0 | CCCN(CCC)C1CCn2ncc(Cl)c2C1 | 10.1021/jm0503805 | ||
54456 | 161940 | 27 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 179 | 0 | 3 | 3 | 1.3 | CC1NCCc2cc(O)c(O)cc21 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL416732 | 161940 | 27 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 179 | 0 | 3 | 3 | 1.3 | CC1NCCc2cc(O)c(O)cc21 | 10.1016/S0960-894X(97)00194-7 | ||
155568867 | 175580 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4592753 | 175580 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 297 | 4 | 1 | 5 | 1.2 | O=C(CN1CCN(c2ccccn2)CC1)Nc1cccnc1 | 10.1021/acs.jmedchem.9b00231 | ||
71658206 | 89976 | 0 | None | -42 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Cl)nc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386620 | 89976 | 0 | None | -42 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 8 | 1 | 5 | 3.5 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Cl)nc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
11316709 | 167806 | 0 | None | -77 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | ||
CHEMBL434532 | 167806 | 0 | None | -77 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | ||
10761828 | 38439 | 0 | None | -3 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 4 | 1 | 5 | 4.4 | Oc1nc2ccccc2n1C1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
CHEMBL146557 | 38439 | 0 | None | -3 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 4 | 1 | 5 | 4.4 | Oc1nc2ccccc2n1C1CCN(Cc2ccn(-c3ccccc3)c2)CC1 | 10.1021/jm00025a013 | ||
168274850 | 189562 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 405 | 6 | 0 | 5 | 4.4 | FC(F)(F)Oc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5173767 | 189562 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 405 | 6 | 0 | 5 | 4.4 | FC(F)(F)Oc1cccc(CO[C@H]2CCCN(Cc3cn4ccccc4n3)C2)c1 | 10.1016/j.bmcl.2022.128615 | ||
2993172 | 126646 | 3 | None | -32 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 297 | 6 | 0 | 3 | 3.0 | c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1 | 10.1021/jm049720x | ||
CHEMBL365697 | 126646 | 3 | None | -32 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 297 | 6 | 0 | 3 | 3.0 | c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1 | 10.1021/jm049720x | ||
9828632 | 99608 | 0 | None | -8 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 535 | 6 | 1 | 4 | 5.5 | COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(98)00469-7 | ||
CHEMBL287198 | 99608 | 0 | None | -8 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 535 | 6 | 1 | 4 | 5.5 | COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(98)00469-7 | ||
763343 | 91709 | 8 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 258 | 3 | 0 | 3 | 3.1 | c1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420769 | 91709 | 8 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 258 | 3 | 0 | 3 | 3.1 | c1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | ||
10137747 | 119668 | 0 | None | 4 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 433 | 4 | 0 | 4 | 3.8 | COc1ccc(C)cc1CN1CCN(C2CCc3cccc4c3N(C2=O)C(C)(C)C4)CC1 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL351612 | 119668 | 0 | None | 4 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 433 | 4 | 0 | 4 | 3.8 | COc1ccc(C)cc1CN1CCN(C2CCc3cccc4c3N(C2=O)C(C)(C)C4)CC1 | 10.1016/s0960-894x(02)01056-9 | ||
164621610 | 185609 | 0 | None | -4 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4872800 | 185609 | 0 | None | -4 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 355 | 4 | 0 | 4 | 3.3 | O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
11676195 | 193478 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 3.4 | CSc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
CHEMBL550222 | 193478 | 0 | None | 1 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 3.4 | CSc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm900690y | ||
72737730 | 114028 | 0 | None | 42 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335554 | 114028 | 0 | None | 42 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 365 | 6 | 0 | 3 | 4.4 | FC(F)(F)Oc1ccc(CN2CCO[C@H](CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
155535272 | 171465 | 0 | None | -177 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 280 | 5 | 0 | 2 | 3.8 | CCCCN1CCN(c2cccc(CC)c2Cl)CC1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4471669 | 171465 | 0 | None | -177 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 280 | 5 | 0 | 2 | 3.8 | CCCCN1CCN(c2cccc(CC)c2Cl)CC1 | 10.1021/acs.jmedchem.6b00860 | ||
60165535 | 75000 | 0 | None | -12 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 4.7 | c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2 | 10.1016/j.ejmech.2012.03.042 | ||
CHEMBL2037522 | 75000 | 0 | None | -12 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 4.7 | c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2 | 10.1016/j.ejmech.2012.03.042 | ||
11428005 | 4988 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccccc1OCC1CN(Cc2cccc(Cl)c2)CCO1 | 10.1021/jm031111m | ||
CHEMBL105312 | 4988 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccccc1OCC1CN(Cc2cccc(Cl)c2)CCO1 | 10.1021/jm031111m | ||
44304643 | 201584 | 0 | None | 1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 8 | 0 | 5 | 5.1 | COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64668 | 201584 | 0 | None | 1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 8 | 0 | 5 | 5.1 | COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
11028157 | 201033 | 0 | None | -128 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 563 | 8 | 1 | 4 | 6.3 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12 | 10.1021/jm020952a | ||
CHEMBL61789 | 201033 | 0 | None | -128 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 563 | 8 | 1 | 4 | 6.3 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12 | 10.1021/jm020952a | ||
30982708 | 10582 | 5 | None | -134 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 384 | 3 | 2 | 2 | 4.4 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1170683 | 10582 | 5 | None | -134 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 384 | 3 | 2 | 2 | 4.4 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
71658203 | 89973 | 0 | None | -57 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 4.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cccc3c2-c2ccccc2C3=O)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386617 | 89973 | 0 | None | -57 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 4.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2cccc3c2-c2ccccc2C3=O)CC1 | 10.1016/j.bmc.2013.03.074 | ||
11247757 | 133056 | 0 | None | -70 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | ||
CHEMBL371200 | 133056 | 0 | None | -70 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | ||
44431465 | 150204 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2cccc(Br)c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL395631 | 150204 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 4 | 1 | 2 | 5.0 | O=C(NC1CCN(Cc2cccc(Br)c2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
137645574 | 157261 | 0 | None | -70 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 7 | 3 | 6 | 3.1 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4083239 | 157261 | 0 | None | -70 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 7 | 3 | 6 | 3.1 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
45271691 | 193880 | 0 | None | 46 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 369 | 3 | 0 | 5 | 3.6 | Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL554692 | 193880 | 0 | None | 46 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 369 | 3 | 0 | 5 | 3.6 | Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
45272580 | 194782 | 0 | None | 13 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL563109 | 194782 | 0 | None | 13 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 351 | 4 | 0 | 6 | 2.7 | COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1 | 10.1016/j.bmc.2009.05.015 | ||
145993700 | 166776 | 0 | None | -75 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 370 | 7 | 3 | 5 | 2.7 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(O)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4294279 | 166776 | 0 | None | -75 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 370 | 7 | 3 | 5 | 2.7 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(O)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
56833379 | 67992 | 0 | None | -54 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1155 | 37 | 2 | 18 | 8.6 | COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2009919 | ||
CHEMBL1916550 | 67992 | 0 | None | -54 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1155 | 37 | 2 | 18 | 8.6 | COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1 | 10.1021/jm2009919 | ||
CHEMBL5089932 | 213459 | 0 | None | -25 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | CCc1cc(Cl)c(OC)c(C(=O)NC[C@@H]2CCCN2CCCCNCCC(C(=O)N(C)C)(c2ccccc2)c2ccccc2)c1O | 10.1021/acs.jmedchem.1c00611 | ||||
46227273 | 198129 | 0 | None | -2 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 281 | 3 | 0 | 2 | 3.8 | COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C | 10.1016/j.bmc.2009.08.028 | ||
CHEMBL594127 | 198129 | 0 | None | -2 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 281 | 3 | 0 | 2 | 3.8 | COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C | 10.1016/j.bmc.2009.08.028 | ||
155195487 | 172705 | 0 | None | -14 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CC1CC1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
CHEMBL4525362 | 172705 | 0 | None | -14 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 433 | 7 | 3 | 5 | 3.4 | C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1CC1CC1CCNC(=O)c1cc2ccccc2[nH]1 | 10.1021/acs.jmedchem.9b00702 | ||
49799709 | 14291 | 0 | None | -24 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 446 | 6 | 2 | 3 | 4.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3cccc(OCCF)c23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1173711 | 14291 | 0 | None | -24 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 446 | 6 | 2 | 3 | 4.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3cccc(OCCF)c23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200302 | 14291 | 0 | None | -24 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 446 | 6 | 2 | 3 | 4.8 | OC1(c2ccc(Br)cc2)CCN(Cc2c[nH]c3cccc(OCCF)c23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
44361021 | 118281 | 0 | None | -23 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1 | 10.1021/jm025558r | ||
CHEMBL342060 | 118281 | 0 | None | -23 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1 | 10.1021/jm025558r | ||
44335971 | 5245 | 0 | None | 18 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 4.0 | CC(c1ccc(Cl)cc1)N1CCN(CC(=O)N2c3ccccc3CC2C)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106751 | 5245 | 0 | None | 18 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 4.0 | CC(c1ccc(Cl)cc1)N1CCN(CC(=O)N2c3ccccc3CC2C)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
10740969 | 98629 | 0 | None | 3 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 3.4 | COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL28063 | 98629 | 0 | None | 3 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 7 | 1 | 5 | 3.4 | COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
11849267 | 79462 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.7 | CO/N=C(\CCN1CCN(c2ccccn2)CC1C)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL212292 | 79462 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 372 | 6 | 0 | 5 | 3.7 | CO/N=C(\CCN1CCN(c2ccccn2)CC1C)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
127052488 | 140268 | 0 | None | -2 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 8 | 0 | 4 | 6.3 | Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818799 | 140268 | 0 | None | -2 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 8 | 0 | 4 | 6.3 | Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2016.06.011 | ||
11133602 | 30559 | 0 | None | -3 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm0611152 | ||
CHEMBL139600 | 30559 | 0 | None | -3 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm0611152 | ||
44361021 | 118281 | 0 | None | -23 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1 | 10.1021/jm0611152 | ||
CHEMBL342060 | 118281 | 0 | None | -23 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1 | 10.1021/jm0611152 | ||
45361874 | 169454 | 2 | None | 48 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4442548 | 169454 | 2 | None | 48 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 5 | 1 | 4 | 2.4 | CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
25139481 | 184257 | 0 | None | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 392 | 10 | 1 | 2 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1 | 10.1021/jm800895v | ||
CHEMBL485227 | 184257 | 0 | None | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 392 | 10 | 1 | 2 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1 | 10.1021/jm800895v | ||
154706590 | 175735 | 1 | None | -36 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4590839 | 175735 | 1 | None | -36 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595264 | 175735 | 1 | None | -36 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1 | 10.1021/acs.jmedchem.9b01835 | ||
127049061 | 140236 | 0 | None | -4 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 5.3 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818398 | 140236 | 0 | None | -4 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 5.3 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL5081136 | 212953 | 0 | None | -309 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | CCc1cc(Cl)c(OC)c(C(=O)NC[C@@H]2C[C@@H](OCCCCNCCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CN2)c1O | 10.1021/acs.jmedchem.1c00611 | ||||
155516042 | 175719 | 0 | None | -446 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4443039 | 175719 | 0 | None | -446 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595150 | 175719 | 0 | None | -446 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
154703875 | 175874 | 1 | None | -52 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4586582 | 175874 | 1 | None | -52 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596341 | 175874 | 1 | None | -52 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
10827222 | 6907 | 1 | None | -61 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL108463 | 6907 | 1 | None | -61 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
127049061 | 140236 | 0 | None | -4 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 5.3 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818398 | 140236 | 0 | None | -4 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 6 | 1 | 5 | 5.3 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
44438231 | 93176 | 3 | None | -4 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 3 | 2 | 3 | 4.4 | OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2n[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246642 | 93176 | 3 | None | -4 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 3 | 2 | 3 | 4.4 | OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2n[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2006.10.076 | ||
10927750 | 7297 | 0 | None | 1 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 411 | 6 | 1 | 3 | 4.2 | O=C(NCCCN1CCN(c2ccccc2)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm010146o | ||
CHEMBL108637 | 7297 | 0 | None | 1 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 411 | 6 | 1 | 3 | 4.2 | O=C(NCCCN1CCN(c2ccccc2)CC1)c1ccc2c(c1)Cc1ccccc1-2 | 10.1021/jm010146o | ||
44438208 | 92938 | 2 | None | -3 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 4 | 2 | 3 | 3.7 | COc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL245614 | 92938 | 2 | None | -3 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 4 | 2 | 3 | 3.7 | COc1ccc(C2(O)CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.10.076 | ||
11133602 | 30559 | 0 | None | -3 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
CHEMBL139600 | 30559 | 0 | None | -3 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm025558r | ||
10713620 | 39156 | 0 | None | -19 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 4 | 2 | 3 | 5.1 | Oc1ccc(C2=CCN(C[C@@H]3CCC=C(c4ccc(O)cc4)C3)CC2)cc1 | 10.1021/jm00026a007 | ||
CHEMBL147159 | 39156 | 0 | None | -19 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 4 | 2 | 3 | 5.1 | Oc1ccc(C2=CCN(C[C@@H]3CCC=C(c4ccc(O)cc4)C3)CC2)cc1 | 10.1021/jm00026a007 | ||
127052488 | 140268 | 0 | None | -2 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 8 | 0 | 4 | 6.3 | Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3818799 | 140268 | 0 | None | -2 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 8 | 0 | 4 | 6.3 | Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2016.06.011 | ||
57390118 | 68960 | 0 | None | -77 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 953 | 32 | 2 | 13 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928126 | 68960 | 0 | None | -77 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 953 | 32 | 2 | 13 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
22100970 | 102352 | 4 | None | 10 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 4.5 | Clc1ccc(CN2CC=C(c3nc4ccccc4[nH]3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL305481 | 102352 | 4 | None | 10 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 4.5 | Clc1ccc(CN2CC=C(c3nc4ccccc4[nH]3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
10073022 | 85631 | 0 | None | -4 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 461 | 9 | 0 | 2 | 7.1 | Fc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCc2ccccc2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
CHEMBL2308105 | 85631 | 0 | None | -4 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 461 | 9 | 0 | 2 | 7.1 | Fc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCc2ccccc2)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
72545008 | 92691 | 0 | None | 1 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 451 | 15 | 0 | 9 | 1.6 | COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
CHEMBL2443001 | 92691 | 0 | None | 1 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 451 | 15 | 0 | 9 | 1.6 | COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1 | 10.1016/j.bmcl.2013.09.026 | ||
10960333 | 205256 | 0 | None | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 398 | 5 | 0 | 6 | 3.5 | CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1021/jm015522j | ||
CHEMBL91362 | 205256 | 0 | None | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 398 | 5 | 0 | 6 | 3.5 | CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12 | 10.1021/jm015522j | ||
10827222 | 6907 | 1 | None | -61 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1 | 10.1021/jm950721m | ||
CHEMBL108463 | 6907 | 1 | None | -61 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 288 | 3 | 0 | 2 | 3.6 | C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1 | 10.1021/jm950721m | ||
44275820 | 13854 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.8 | Cc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1196753 | 13854 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.8 | Cc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL558036 | 13854 | 0 | None | -2 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 4.8 | Cc1ccccc1N1CCN(CCCCc2cc(-c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
44123782 | 189009 | 0 | None | -6 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 338 | 3 | 1 | 3 | 3.7 | Clc1ccc(N2CC3CC2CN3Cc2c[nH]c3ncccc23)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL514747 | 189009 | 0 | None | -6 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 338 | 3 | 1 | 3 | 3.7 | Clc1ccc(N2CC3CC2CN3Cc2c[nH]c3ncccc23)cc1 | 10.1016/j.bmc.2008.12.054 | ||
71456889 | 81412 | 0 | None | -36 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 466 | 7 | 0 | 5 | 4.7 | COc1ccccc1N1CCN(CCN(C(=O)c2cccc3ccccc23)c2ccccn2)CC1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164348 | 81412 | 0 | None | -36 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 466 | 7 | 0 | 5 | 4.7 | COc1ccccc1N1CCN(CCN(C(=O)c2cccc3ccccc23)c2ccccn2)CC1 | 10.1016/j.bmcl.2012.05.119 | ||
44431476 | 87149 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL233578 | 87149 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1ccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2006.12.106 | ||
25139477 | 183663 | 0 | None | -15 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 486 | 10 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm800895v | ||
CHEMBL483593 | 183663 | 0 | None | -15 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 486 | 10 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1 | 10.1021/jm800895v | ||
44436618 | 147390 | 0 | None | -45 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 443 | 8 | 1 | 3 | 4.7 | C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL393365 | 147390 | 0 | None | -45 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 443 | 8 | 1 | 3 | 4.7 | C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
130442572 | 171342 | 0 | None | -147 | 24 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
CHEMBL4469848 | 171342 | 0 | None | -147 | 24 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
130442480 | 174698 | 0 | None | -85 | 24 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | ||
CHEMBL4572614 | 174698 | 0 | None | -85 | 24 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | ||
2812 | 4711 | 96 | None | -39 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
CHEMBL104 | 4711 | 96 | None | -39 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
44340333 | 9571 | 0 | None | 19 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 3.8 | C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL112833 | 9571 | 0 | None | 19 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 3.8 | C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
21462980 | 46871 | 0 | None | 23 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 2 | 1 | 2 | 3.1 | c1ccc2c(c1)CCN(Cc1c[nH]c3ncccc13)C2 | 10.1016/s0960-894x(99)00025-6 | ||
CHEMBL154286 | 46871 | 0 | None | 23 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 2 | 1 | 2 | 3.1 | c1ccc2c(c1)CCN(Cc1c[nH]c3ncccc13)C2 | 10.1016/s0960-894x(99)00025-6 | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm00004a016 | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm00004a016 | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm00004a016 | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm00004a016 | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm00004a016 | ||
9861459 | 163566 | 0 | None | -17 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 309 | 4 | 3 | 4 | 2.8 | Oc1nc2c3c(ccc2[nH]1)CC[C@H](CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
CHEMBL420986 | 163566 | 0 | None | -17 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 309 | 4 | 3 | 4 | 2.8 | Oc1nc2c3c(ccc2[nH]1)CC[C@H](CNCc1ccccc1)O3 | 10.1016/s0960-894x(01)00778-8 | ||
6469918 | 79481 | 13 | None | 169 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1016/j.ejmech.2019.111569 | ||
CHEMBL212370 | 79481 | 13 | None | 169 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1016/j.ejmech.2019.111569 | ||
10646834 | 106680 | 0 | None | 14 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 4.1 | COc1cc(NC(=O)C2CCC2)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL316317 | 106680 | 0 | None | 14 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 4.1 | COc1cc(NC(=O)C2CCC2)c(Cl)cc1C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
44336099 | 110199 | 0 | None | 38 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(Cl)cc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL326010 | 110199 | 0 | None | 38 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 417 | 4 | 0 | 3 | 4.1 | C[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2cc(Cl)cc(Cl)c2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
44336051 | 110818 | 0 | None | 16 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 4.0 | C[C@@H]1c2ccccc2N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)[C@@H]1C | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL326670 | 110818 | 0 | None | 16 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 4.0 | C[C@@H]1c2ccccc2N(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)[C@@H]1C | 10.1016/s0960-894x(02)00655-8 | ||
44335798 | 4776 | 0 | None | 213 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccccc1CN1CCN(CC(=O)N2c3ccccc3CC2C)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104256 | 4776 | 0 | None | 213 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 363 | 4 | 0 | 3 | 3.1 | Cc1ccccc1CN1CCN(CC(=O)N2c3ccccc3CC2C)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335924 | 4846 | 0 | None | 125 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104614 | 4846 | 0 | None | 125 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 4 | 0 | 3 | 2.9 | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335886 | 4871 | 0 | None | 7 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 366 | 4 | 0 | 2 | 4.4 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104719 | 4871 | 0 | None | 7 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 366 | 4 | 0 | 2 | 4.4 | CC1Cc2ccccc2N1C(=O)CC1CCN(Cc2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
44335991 | 4887 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 405 | 5 | 0 | 4 | 2.8 | O=S1(=O)Cc2ccccc2N1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104800 | 4887 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 405 | 5 | 0 | 4 | 2.8 | O=S1(=O)Cc2ccccc2N1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00025a013 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00025a013 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00025a013 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00025a013 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm00025a013 | ||
44405522 | 71585 | 0 | None | 251 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 4.1 | O=C(N[C@H]1CCN(Cc2ccc3c(c2)OCO3)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL197225 | 71585 | 0 | None | 251 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 4.1 | O=C(N[C@H]1CCN(Cc2ccc3c(c2)OCO3)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
6469918 | 79481 | 13 | None | 169 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
CHEMBL212370 | 79481 | 13 | None | 169 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1 | 10.1021/jm060166w | ||
11338828 | 4966 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 409 | 7 | 0 | 4 | 5.1 | CCOc1cc(Cl)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL105181 | 4966 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 409 | 7 | 0 | 4 | 5.1 | CCOc1cc(Cl)ccc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
9820680 | 204482 | 0 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 369 | 6 | 2 | 3 | 4.4 | FC(F)(F)c1nc2c(OCCNCc3ccccc3)cc(Cl)cc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL86504 | 204482 | 0 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 369 | 6 | 2 | 3 | 4.4 | FC(F)(F)c1nc2c(OCCNCc3ccccc3)cc(Cl)cc2[nH]1 | 10.1016/s0960-894x(99)00434-5 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | ||
71151588 | 117755 | 0 | None | -70 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 518 | 9 | 1 | 7 | 3.6 | NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.045 | ||
CHEMBL3409256 | 117755 | 0 | None | -70 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 518 | 9 | 1 | 7 | 3.6 | NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.045 | ||
25071385 | 158611 | 0 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 408 | 9 | 0 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4098236 | 158611 | 0 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 408 | 9 | 0 | 7 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
133079 | 3581 | 33 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/jm960084f | ||
980 | 3581 | 33 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/jm960084f | ||
CHEMBL69759 | 3581 | 33 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 10.1021/jm960084f | ||
2563 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/s0960-894x(01)00167-6 | ||
55 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/s0960-894x(01)00167-6 | ||
91273 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/s0960-894x(01)00167-6 | ||
CHEMBL274047 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/s0960-894x(01)00167-6 | ||
DB12833 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | 10.1016/s0960-894x(01)00167-6 | ||
53361302 | 63519 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 493 | 13 | 0 | 8 | 4.4 | CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803049 | 63519 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 493 | 13 | 0 | 8 | 4.4 | CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
53361302 | 63519 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 493 | 13 | 0 | 8 | 4.4 | CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2009919 | ||
CHEMBL1803049 | 63519 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 493 | 13 | 0 | 8 | 4.4 | CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2009919 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049612a | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049612a | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049612a | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049612a | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049612a | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960637m | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960637m | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960637m | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960637m | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm960637m | ||
10905940 | 44947 | 0 | None | -3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 421 | 7 | 1 | 4 | 3.9 | COc1cccc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL152576 | 44947 | 0 | None | -3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 421 | 7 | 1 | 4 | 3.9 | COc1cccc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
56926586 | 68667 | 0 | None | 316 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 3 | 1 | 5 | 2.6 | Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F | 10.1021/jm200762g | ||
CHEMBL1923415 | 68667 | 0 | None | 316 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 3 | 1 | 5 | 2.6 | Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F | 10.1021/jm200762g | ||
44339953 | 109212 | 0 | None | 3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 387 | 5 | 2 | 4 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL322802 | 109212 | 0 | None | 3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 387 | 5 | 2 | 4 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C | 10.1016/s0960-894x(03)00678-4 | ||
72164181 | 91715 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 274 | 3 | 1 | 4 | 2.8 | Oc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420774 | 91715 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 274 | 3 | 1 | 4 | 2.8 | Oc1ccccc1N1CCN(Cc2cccs2)CC1 | 10.1016/j.bmcl.2013.07.033 | ||
127027905 | 138926 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 5 | 0 | 3 | 4.3 | Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3794079 | 138926 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 5 | 0 | 3 | 4.3 | Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C | 10.1016/j.bmcl.2016.03.102 | ||
3069135 | 69821 | 2 | None | 3 | 6 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 314 | 6 | 0 | 3 | 3.4 | Fc1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940412 | 69821 | 2 | None | 3 | 6 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 314 | 6 | 0 | 3 | 3.4 | Fc1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
10687362 | 106125 | 0 | None | 288 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 323 | 2 | 0 | 3 | 3.8 | Cc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(F)cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL314285 | 106125 | 0 | None | 288 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 323 | 2 | 0 | 3 | 3.8 | Cc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(F)cc1)CC3 | 10.1021/jm970170v | ||
10570898 | 204769 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 3.3 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc([N+](=O)[O-])cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL88296 | 204769 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 3.3 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc([N+](=O)[O-])cc1)CC3 | 10.1021/jm970170v | ||
10833953 | 30909 | 0 | None | 1445 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 384 | 3 | 1 | 3 | 4.7 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1 | 10.1021/jm0009989 | ||
CHEMBL140006 | 30909 | 0 | None | 1445 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 384 | 3 | 1 | 3 | 4.7 | N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1 | 10.1021/jm0009989 | ||
11811640 | 164714 | 0 | None | 6 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 408 | 8 | 1 | 6 | 3.2 | COc1cccc(C(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL423040 | 164714 | 0 | None | 6 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 408 | 8 | 1 | 6 | 3.2 | COc1cccc(C(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1 | 10.1021/jm020952a | ||
44395741 | 180999 | 0 | None | 1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
CHEMBL476935 | 180999 | 0 | None | 1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
CHEMBL558392 | 180999 | 0 | None | 1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm100899z | ||
44372009 | 48575 | 0 | None | 109 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 402 | 4 | 0 | 4 | 5.0 | Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL155913 | 48575 | 0 | None | 109 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 402 | 4 | 0 | 4 | 5.0 | Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1 | 10.1016/s0960-894x(01)00814-9 | ||
10593191 | 188519 | 0 | None | 33 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1021/jm970021c | ||
CHEMBL51023 | 188519 | 0 | None | 33 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1021/jm970021c | ||
10593191 | 188519 | 0 | None | 33 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL51023 | 188519 | 0 | None | 33 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.5 | COc1ccccc1N1CCN(CNC(=O)c2ccc(C)cc2)CC1 | 10.1016/j.bmcl.2005.02.012 | ||
2402 | 3318 | 58 | None | -2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | ||
5095 | 3318 | 58 | None | -2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | ||
7295 | 3318 | 58 | None | -2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | ||
CHEMBL589 | 3318 | 58 | None | -2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | ||
DB00268 | 3318 | 58 | None | -2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | ||
9798466 | 133755 | 1 | None | 1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C | 10.1021/jm0002432 | ||
CHEMBL37170 | 133755 | 1 | None | 1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C | 10.1021/jm0002432 | ||
57401819 | 69817 | 0 | None | 10 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 346 | 6 | 0 | 2 | 4.6 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940408 | 69817 | 0 | None | 10 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 346 | 6 | 0 | 2 | 4.6 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57401819 | 69817 | 0 | None | 10 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 346 | 6 | 0 | 2 | 4.6 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940408 | 69817 | 0 | None | 10 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 346 | 6 | 0 | 2 | 4.6 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
137657115 | 159208 | 0 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4105030 | 159208 | 0 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 9 | 1 | 8 | 3.1 | COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
9798466 | 133755 | 1 | None | 1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL37170 | 133755 | 1 | None | 1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
10568805 | 168601 | 0 | None | 74 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 3.4 | COc1ccc2c3c(c(=O)oc2c1)CN(CCc1ccccc1)CC3 | 10.1021/jm970170v | ||
CHEMBL440506 | 168601 | 0 | None | 74 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 3.4 | COc1ccc2c3c(c(=O)oc2c1)CN(CCc1ccccc1)CC3 | 10.1021/jm970170v | ||
164620912 | 185153 | 0 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 2.6 | OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
CHEMBL4866053 | 185153 | 0 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 2.6 | OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1 | 10.1016/j.ejmech.2021.113243 | ||
137640371 | 156273 | 0 | None | -5 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 421 | 10 | 1 | 6 | 4.3 | CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4071185 | 156273 | 0 | None | -5 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 421 | 10 | 1 | 6 | 4.3 | CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | ||
44273908 | 76363 | 0 | None | 100 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.5 | CC1(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)CCCCC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20655 | 76363 | 0 | None | 100 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.5 | CC1(C(=O)NCCN2CCN(c3ccc(Cl)cc3)CC2)CCCCC1 | 10.1016/0960-894X(96)00198-9 | ||
44273887 | 76698 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.4 | CCCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL20725 | 76698 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.4 | CCCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
10359736 | 99053 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 3.0 | CCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL283353 | 99053 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 3.0 | CCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/0960-894X(96)00198-9 | ||
44394675 | 165819 | 0 | None | 53 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 384 | 6 | 1 | 3 | 4.2 | O=Cc1ccc(-c2ccc(C(=O)NC3CCN(Cc4ccccc4)C3)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL427522 | 165819 | 0 | None | 53 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 384 | 6 | 1 | 3 | 4.2 | O=Cc1ccc(-c2ccc(C(=O)NC3CCN(Cc4ccccc4)C3)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960637m | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960637m | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960637m | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960637m | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960637m | ||
57391897 | 68967 | 0 | None | -7 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 481 | 12 | 1 | 8 | 2.7 | CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928133 | 68967 | 0 | None | -7 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 481 | 12 | 1 | 8 | 2.7 | CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1 | 10.1016/j.bmc.2011.10.063 | ||
45270021 | 193494 | 0 | None | 60 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 3 | 0 | 5 | 3.0 | Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL550392 | 193494 | 0 | None | 60 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 3 | 0 | 5 | 3.0 | Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1 | 10.1016/j.bmc.2009.05.015 | ||
11382447 | 109178 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(Cl)cc1OCC1CN(Cc2ccccc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL322519 | 109178 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1ccc(Cl)cc1OCC1CN(Cc2ccccc2)CCO1 | 10.1021/jm031111m | ||
60149678 | 114019 | 0 | None | 229 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CC[C@@H]2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335537 | 114019 | 0 | None | 229 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 3.4 | c1ccc(CC[C@@H]2CN(Cc3nc4ccccc4[nH]3)CCO2)cc1 | 10.1021/ml500267c | ||
57267 | 1563 | 11 | None | -416 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 10.1021/acs.jmedchem.6b01373 | ||
966 | 1563 | 11 | None | -416 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 10.1021/acs.jmedchem.6b01373 | ||
CHEMBL8946 | 1563 | 11 | None | -416 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 10.1021/acs.jmedchem.6b01373 | ||
DB15492 | 1563 | 11 | None | -416 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 10.1021/acs.jmedchem.6b01373 | ||
9865858 | 162754 | 0 | None | -44 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 6 | 1 | 5 | 4.0 | COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1 | 10.1021/jm9910122 | ||
CHEMBL418854 | 162754 | 0 | None | -44 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 6 | 1 | 5 | 4.0 | COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1 | 10.1021/jm9910122 | ||
49798879 | 10511 | 4 | None | -275 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 414 | 4 | 2 | 3 | 4.4 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(Br)cc4)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1170096 | 10511 | 4 | None | -275 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 414 | 4 | 2 | 3 | 4.4 | COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(Br)cc4)CC3)c2c1 | 10.1016/j.bmc.2010.05.052 | ||
44319369 | 204105 | 0 | None | 2 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 3.0 | C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL83306 | 204105 | 0 | None | 2 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 3.0 | C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1 | 10.1016/s0960-894x(01)00484-x | ||
44380716 | 58778 | 0 | None | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 429 | 7 | 1 | 4 | 3.6 | COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL169631 | 58778 | 0 | None | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 429 | 7 | 1 | 4 | 3.6 | COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(99)00086-4 | ||
44324980 | 205688 | 0 | None | -1318 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1COC[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/jm960345l | ||
CHEMBL94015 | 205688 | 0 | None | -1318 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 249 | 2 | 1 | 4 | 1.9 | CCCN1COC[C@@H]2c3cc(O)ccc3OC[C@H]21 | 10.1021/jm960345l | ||
10310103 | 106828 | 0 | None | -1778 | 9 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 425 | 5 | 0 | 5 | 5.3 | N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | ||
CHEMBL317333 | 106828 | 0 | None | -1778 | 9 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 425 | 5 | 0 | 5 | 5.3 | N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | ||
9865920 | 107047 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 403 | 4 | 0 | 3 | 3.7 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccc(Cl)cc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL318739 | 107047 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 403 | 4 | 0 | 3 | 3.7 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccc(Cl)cc21 | 10.1016/s0960-894x(02)00655-8 | ||
9887092 | 102201 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 4.1 | CCN1C(=O)C(CC)(N2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
CHEMBL304584 | 102201 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 397 | 5 | 0 | 3 | 4.1 | CCN1C(=O)C(CC)(N2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(00)00421-2 | ||
71658338 | 89979 | 0 | None | -97 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 410 | 9 | 2 | 5 | 3.5 | CNc1ccc(C(=O)NCCCCN2CCCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386623 | 89979 | 0 | None | -97 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 410 | 9 | 2 | 5 | 3.5 | CNc1ccc(C(=O)NCCCCN2CCCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2013.03.074 | ||
10569690 | 205344 | 10 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 347 | 4 | 1 | 4 | 4.4 | Cc1nc(O)n(C2CCN(Cc3ccccc3)CC2)c1-c1ccccc1 | 10.1021/jm991029k | ||
CHEMBL91821 | 205344 | 10 | None | 3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 347 | 4 | 1 | 4 | 4.4 | Cc1nc(O)n(C2CCN(Cc3ccccc3)CC2)c1-c1ccccc1 | 10.1021/jm991029k | ||
73346042 | 91402 | 3 | None | -707 | 17 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 405 | 9 | 0 | 8 | 0.9 | Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O | 10.1016/j.bmc.2013.05.050 | ||
CHEMBL2413153 | 91402 | 3 | None | -707 | 17 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 405 | 9 | 0 | 8 | 0.9 | Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O | 10.1016/j.bmc.2013.05.050 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00025a013 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00025a013 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00025a013 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00025a013 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm00025a013 | ||
56649648 | 67513 | 0 | None | -213 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 474 | 8 | 0 | 5 | 3.0 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 | 10.1016/j.ejmech.2011.06.023 | ||
CHEMBL1910139 | 67513 | 0 | None | -213 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 474 | 8 | 0 | 5 | 3.0 | COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 | 10.1016/j.ejmech.2011.06.023 | ||
44426499 | 141533 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 372 | 6 | 1 | 2 | 4.7 | O=C(NC1CCN(CCCc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
CHEMBL387951 | 141533 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 372 | 6 | 1 | 2 | 4.7 | O=C(NC1CCN(CCCc2ccccc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.096 | ||
11451703 | 138489 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 376 | 6 | 0 | 5 | 3.4 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060279f | ||
CHEMBL378576 | 138489 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 376 | 6 | 0 | 5 | 3.4 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccc(F)c(Cl)c1 | 10.1021/jm060279f | ||
12050195 | 201593 | 0 | None | 1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 441 | 6 | 0 | 5 | 4.4 | COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
CHEMBL64696 | 201593 | 0 | None | 1 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 441 | 6 | 0 | 5 | 4.4 | COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1 | 10.1016/s0960-894x(00)00405-4 | ||
130431287 | 170651 | 0 | None | -223 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.0 | CCc1cc(Cl)c(OC)c(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4459533 | 170651 | 0 | None | -223 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.0 | CCc1cc(Cl)c(OC)c(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1 | 10.1021/acs.jmedchem.6b00860 | ||
44315403 | 203760 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 3 | 1 | 4 | 2.9 | Clc1ccccc1N1CCN(Cc2nc3ccc[nH]c-3n2)CC1 | 10.1021/jm0305669 | ||
CHEMBL80469 | 203760 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 3 | 1 | 4 | 2.9 | Clc1ccccc1N1CCN(Cc2nc3ccc[nH]c-3n2)CC1 | 10.1021/jm0305669 | ||
44278456 | 99424 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 7 | 0 | 2 | 5.8 | CC(COc1cccc2ccccc12)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL28596 | 99424 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 7 | 0 | 2 | 5.8 | CC(COc1cccc2ccccc12)CN1CCC(Cc2ccccc2)CC1 | 10.1016/S0960-894X(97)00233-3 | ||
122205438 | 136875 | 0 | None | -47 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 307 | 0 | 0 | 2 | 4.5 | CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 | 10.1039/C5MD00258C | ||
CHEMBL3753266 | 136875 | 0 | None | -47 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 307 | 0 | 0 | 2 | 4.5 | CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 | 10.1039/C5MD00258C | ||
11121216 | 29925 | 0 | None | -36 | 14 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
CHEMBL138989 | 29925 | 0 | None | -36 | 14 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
128054 | 203431 | 5 | None | -39 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN(CCc1ccsc1)C1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
CHEMBL7806 | 203431 | 5 | None | -39 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 315 | 6 | 1 | 3 | 4.3 | CCCN(CCc1ccsc1)C1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
127032085 | 138858 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 363 | 5 | 0 | 5 | 3.3 | FC1(F)Oc2ccc(CN3CCO[C@H](COc4ccccc4)C3)cc2O1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793266 | 138858 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 363 | 5 | 0 | 5 | 3.3 | FC1(F)Oc2ccc(CN3CCO[C@H](COc4ccccc4)C3)cc2O1 | 10.1016/j.bmcl.2016.03.102 | ||
10247720 | 12943 | 0 | None | 2 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL1190042 | 12943 | 0 | None | 2 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
CHEMBL540039 | 12943 | 0 | None | 2 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 2.2 | c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1 | 10.1016/s0960-894x(01)00484-x | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00194-7 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00194-7 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00194-7 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00194-7 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/S0960-894X(97)00194-7 | ||
49798853 | 14194 | 0 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 363 | 3 | 1 | 4 | 4.4 | O=c1[nH]c2ccccc2n1C1CCN(Cc2csc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1169895 | 14194 | 0 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 363 | 3 | 1 | 4 | 4.4 | O=c1[nH]c2ccccc2n1C1CCN(Cc2csc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1199932 | 14194 | 0 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 363 | 3 | 1 | 4 | 4.4 | O=c1[nH]c2ccccc2n1C1CCN(Cc2csc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
10254390 | 71344 | 0 | None | -5623 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 475 | 8 | 1 | 5 | 5.1 | COc1cccc2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)oc12 | 10.1021/jm020952a | ||
CHEMBL196476 | 71344 | 0 | None | -5623 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 475 | 8 | 1 | 5 | 5.1 | COc1cccc2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)oc12 | 10.1021/jm020952a | ||
10961938 | 119034 | 0 | None | -1202 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 5.5 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2ccccc12 | 10.1021/jm020952a | ||
CHEMBL345820 | 119034 | 0 | None | -1202 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 5.5 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2ccccc12 | 10.1021/jm020952a | ||
145993377 | 166415 | 0 | None | -269 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 430 | 8 | 2 | 4 | 4.6 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4287471 | 166415 | 0 | None | -269 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 430 | 8 | 2 | 4 | 4.6 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
11071135 | 206268 | 0 | None | -3311 | 8 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O | 10.1021/jm020938y | ||
CHEMBL97333 | 206268 | 0 | None | -3311 | 8 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 500 | 6 | 0 | 6 | 4.6 | CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O | 10.1021/jm020938y | ||
137646281 | 157264 | 0 | None | -1659 | 17 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
CHEMBL4083252 | 157264 | 0 | None | -1659 | 17 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
44336003 | 5547 | 0 | None | 8 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 389 | 4 | 0 | 3 | 3.6 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCCC2CCCCC21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107755 | 5547 | 0 | None | 8 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 389 | 4 | 0 | 3 | 3.6 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCCC2CCCCC21 | 10.1016/s0960-894x(02)00655-8 | ||
44336100 | 109288 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 4 | 0 | 3 | 4.5 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2[C@H]2CCCC[C@H]21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL323213 | 109288 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 4 | 0 | 3 | 4.5 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1c2ccccc2[C@H]2CCCC[C@H]21 | 10.1016/s0960-894x(02)00655-8 | ||
30743524 | 4826 | 0 | None | 8 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.4 | O=C(CCN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104498 | 4826 | 0 | None | 8 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 383 | 5 | 0 | 3 | 3.4 | O=C(CCN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
44336031 | 5141 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.6 | CC1Cc2ccccc2N1C(=O)CN1CCC(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106170 | 5141 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 4.6 | CC1Cc2ccccc2N1C(=O)CN1CCC(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
71657946 | 89965 | 0 | None | -398 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 407 | 9 | 1 | 4 | 4.1 | C=Cc1ccc(C(=O)NCCCCN2CCCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386609 | 89965 | 0 | None | -398 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 407 | 9 | 1 | 4 | 4.1 | C=Cc1ccc(C(=O)NCCCCN2CCCN(c3ccccc3OC)CC2)cc1 | 10.1016/j.bmc.2013.03.074 | ||
10559624 | 26184 | 2 | None | -512 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 191 | 1 | 1 | 2 | 1.8 | CN(C)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
CHEMBL135932 | 26184 | 2 | None | -512 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 191 | 1 | 1 | 2 | 1.8 | CN(C)C1CCc2ccc(O)cc2C1 | 10.1021/jm960345l | ||
10494689 | 11462 | 1 | None | -3 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CC[C@@H](CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
CHEMBL1180589 | 11462 | 1 | None | -3 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CC[C@@H](CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
CHEMBL134343 | 11462 | 1 | None | -3 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CC[C@@H](CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
10495881 | 108701 | 0 | None | 3 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.8 | c1ccc(-c2nc(CN3CCN(c4cccnc4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
CHEMBL321513 | 108701 | 0 | None | 3 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.8 | c1ccc(-c2nc(CN3CCN(c4cccnc4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
30616772 | 4720 | 0 | None | 112 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 371 | 5 | 0 | 5 | 3.1 | O=c1oc2ccccc2n1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL104063 | 4720 | 0 | None | 112 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 371 | 5 | 0 | 5 | 3.1 | O=c1oc2ccccc2n1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
127028183 | 138786 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 6 | 0 | 5 | 3.2 | COc1ccc(CN2CCO[C@H](COc3cccc(F)n3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792532 | 138786 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 6 | 0 | 5 | 3.2 | COc1ccc(CN2CCO[C@H](COc3cccc(F)n3)C2)cc1Cl | 10.1016/j.bmcl.2016.03.102 | ||
9886609 | 164777 | 0 | None | -6 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 5 | 1 | 3 | 5.0 | c1ccc(N2CCN(CC[C@H]3CC[C@H](c4c[nH]c5ccccc54)CC3)CC2)nc1 | 10.1021/jm960597m | ||
CHEMBL423499 | 164777 | 0 | None | -6 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 5 | 1 | 3 | 5.0 | c1ccc(N2CCN(CC[C@H]3CC[C@H](c4c[nH]c5ccccc54)CC3)CC2)nc1 | 10.1021/jm960597m | ||
127027238 | 138881 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3ccccn3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793709 | 138881 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.0 | Clc1ccc(CN2CCO[C@H](COc3ccccn3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
44264641 | 203094 | 1 | None | 4 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 230 | 2 | 0 | 4 | 1.1 | CN1CCN(Cc2cnn3ccccc23)CC1 | 10.1016/s0960-894x(98)00692-1 | ||
CHEMBL7505 | 203094 | 1 | None | 4 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 230 | 2 | 0 | 4 | 1.1 | CN1CCN(Cc2cnn3ccccc23)CC1 | 10.1016/s0960-894x(98)00692-1 | ||
12581219 | 25058 | 2 | None | -4 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 205 | 2 | 0 | 2 | 2.1 | COc1cccc2c1CCC(N(C)C)C2 | 10.1021/jm960345l | ||
CHEMBL134866 | 25058 | 2 | None | -4 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 205 | 2 | 0 | 2 | 2.1 | COc1cccc2c1CCC(N(C)C)C2 | 10.1021/jm960345l | ||
CHEMBL4560038 | 212258 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | None | None | None | CCNC(=O)c1cc2c(N3CCOC[C@H]3C)ccnc2n1C | nan | ||||
10567839 | 205305 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 322 | 3 | 0 | 5 | 2.8 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccncc1)CC3 | 10.1021/jm970170v | ||
CHEMBL91585 | 205305 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 322 | 3 | 0 | 5 | 2.8 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccncc1)CC3 | 10.1021/jm970170v | ||
44278853 | 105317 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 405 | 8 | 1 | 4 | 4.5 | COc1ccc(CC2CCN(CC(O)COc3cccc4ccccc34)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
CHEMBL31269 | 105317 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 405 | 8 | 1 | 4 | 4.5 | COc1ccc(CC2CCN(CC(O)COc3cccc4ccccc34)CC2)cc1 | 10.1016/S0960-894X(97)00233-3 | ||
10636896 | 18696 | 1 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccccc1OCCNCCCOc1ccccc1 | 10.1021/jm970422s | ||
CHEMBL128313 | 18696 | 1 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccccc1OCCNCCCOc1ccccc1 | 10.1021/jm970422s | ||
10688157 | 15405 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1cccc(N2CCN(Cc3ccc4oc(=O)ccc4c3)CC2)c1 | 10.1021/jm990266k | ||
CHEMBL122116 | 15405 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.4 | Cc1cccc(N2CCN(Cc3ccc4oc(=O)ccc4c3)CC2)c1 | 10.1021/jm990266k | ||
10636896 | 18696 | 1 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccccc1OCCNCCCOc1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL128313 | 18696 | 1 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 9 | 1 | 3 | 3.4 | Cc1ccccc1OCCNCCCOc1ccccc1 | 10.1016/j.bmcl.2005.02.012 | ||
118719925 | 115279 | 0 | None | 7 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 330 | 7 | 1 | 3 | 2.8 | O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL3354072 | 115279 | 0 | None | 7 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 330 | 7 | 1 | 3 | 2.8 | O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1 | 10.1021/acs.jmedchem.8b00265 | ||
71658077 | 89972 | 0 | None | -56 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 425 | 10 | 2 | 5 | 3.0 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(CCO)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386616 | 89972 | 0 | None | -56 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 425 | 10 | 2 | 5 | 3.0 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(CCO)cc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
9884771 | 16421 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 350 | 4 | 0 | 5 | 3.1 | COc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1 | 10.1021/jm990266k | ||
CHEMBL124050 | 16421 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 350 | 4 | 0 | 5 | 3.1 | COc1ccc(N2CCN(Cc3ccc4ccc(=O)oc4c3)CC2)cc1 | 10.1021/jm990266k | ||
137657427 | 159012 | 0 | None | -67 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 476 | 7 | 3 | 6 | 3.5 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4102628 | 159012 | 0 | None | -67 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 476 | 7 | 3 | 6 | 3.5 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
11570471 | 141385 | 0 | None | -21 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 568 | 12 | 1 | 7 | 4.4 | CCCc1c(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccccc1Br | 10.1021/jm0611152 | ||
CHEMBL386986 | 141385 | 0 | None | -21 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 568 | 12 | 1 | 7 | 4.4 | CCCc1c(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)nnn1Cc1ccccc1Br | 10.1021/jm0611152 | ||
CHEMBL4579981 | 212265 | 8 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | None | None | None | Cc1ccc2[nH]c(CNCCCc3ccncc3)cc(=O)c2c1 | nan | ||||
11092112 | 205894 | 0 | None | -13489 | 9 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 485 | 6 | 0 | 6 | 4.9 | O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | ||
CHEMBL95175 | 205894 | 0 | None | -13489 | 9 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 485 | 6 | 0 | 6 | 4.9 | O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 | 10.1021/jm020938y | ||
46231924 | 198894 | 0 | None | -1737 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL599134 | 198894 | 0 | None | -1737 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | ||
118719807 | 115234 | 0 | None | -81 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 434 | 9 | 0 | 7 | 3.5 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc(N(C)C)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353910 | 115234 | 0 | None | -81 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 434 | 9 | 0 | 7 | 3.5 | COc1ccccc1N1CCN(CCCCc2cn(-c3ccc(N(C)C)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
44403220 | 71582 | 0 | None | -3 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 386 | 8 | 1 | 5 | 2.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL197214 | 71582 | 0 | None | -3 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 386 | 8 | 1 | 5 | 2.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
10375676 | 114705 | 30 | None | -99 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 205 | 3 | 2 | 2 | 2.2 | CCCNC1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
CHEMBL334472 | 114705 | 30 | None | -99 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 205 | 3 | 2 | 2 | 2.2 | CCCNC1CCc2c(O)cccc2C1 | 10.1021/jm960345l | ||
56597938 | 3877 | 1 | None | -204 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
7651 | 3877 | 1 | None | -204 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL2165126 | 3877 | 1 | None | -204 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | ||
122189394 | 122733 | 0 | None | -245 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 469 | 7 | 0 | 7 | 4.4 | Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613880 | 122733 | 0 | None | -245 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 469 | 7 | 0 | 7 | 4.4 | Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl | 10.1016/j.bmc.2015.07.050 | ||
22727361 | 13146 | 0 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 0 | 6 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1191469 | 13146 | 0 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 0 | 6 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL542573 | 13146 | 0 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 0 | 6 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)c(OC)c1 | 10.1016/s0960-894x(02)00179-8 | ||
155530763 | 171003 | 0 | None | 9 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4464861 | 171003 | 0 | None | 9 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.6 | Cc1cccc(NC(=O)CCN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
137655594 | 158094 | 0 | None | -18 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 287 | 3 | 2 | 4 | 1.8 | CCCN1CCN(c2ccc(O)c3[nH]c(=O)ccc23)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4092462 | 158094 | 0 | None | -18 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 287 | 3 | 2 | 4 | 1.8 | CCCN1CCN(c2ccc(O)c3[nH]c(=O)ccc23)CC1 | 10.1016/j.bmc.2017.08.037 | ||
142590721 | 179694 | 0 | None | -6 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 486 | 9 | 1 | 3 | 5.2 | [O-][S+](CCNC1CCN(Cc2ccc(F)cc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4750660 | 179694 | 0 | None | -6 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 486 | 9 | 1 | 3 | 5.2 | [O-][S+](CCNC1CCN(Cc2ccc(F)cc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.ejmech.2020.112674 | ||
44431474 | 87055 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1cccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL233404 | 87055 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.5 | Cc1cccc(CN2CCC(NC(=O)c3cccc4ccccc34)CC2)c1 | 10.1016/j.bmcl.2006.12.106 | ||
57393628 | 68971 | 0 | None | -229 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1005 | 30 | 2 | 17 | 5.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928137 | 68971 | 0 | None | -229 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1005 | 30 | 2 | 17 | 5.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1 | 10.1016/j.bmc.2011.10.063 | ||
440229 | 87083 | 48 | None | -14 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | ||
CHEMBL2334891 | 87083 | 48 | None | -14 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | ||
10895106 | 32011 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
CHEMBL140968 | 32011 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm0611152 | ||
44335979 | 5035 | 0 | None | 8 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1ccc2c(c1)N(C(=O)CN1CCN(Cc3ccc(Cl)cc3)CC1)CC2 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL105595 | 5035 | 0 | None | 8 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.4 | Cc1ccc2c(c1)N(C(=O)CN1CCN(Cc3ccc(Cl)cc3)CC1)CC2 | 10.1016/s0960-894x(02)00655-8 | ||
127052458 | 140209 | 0 | None | -77 | 7 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818056 | 140209 | 0 | None | -77 | 7 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | ||
22727322 | 13825 | 0 | None | -32 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 421 | 9 | 0 | 6 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1196566 | 13825 | 0 | None | -32 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 421 | 9 | 0 | 6 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL557409 | 13825 | 0 | None | -32 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 421 | 9 | 0 | 6 | 4.5 | COc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1OC | 10.1016/s0960-894x(02)00179-8 | ||
154706030 | 175971 | 1 | None | -37 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4580817 | 175971 | 1 | None | -37 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597188 | 175971 | 1 | None | -37 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
127052458 | 140209 | 0 | None | -77 | 7 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818056 | 140209 | 0 | None | -77 | 7 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 295 | 5 | 1 | 3 | 3.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1 | 10.1016/j.bmc.2016.05.053 | ||
44340376 | 110157 | 0 | None | 6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.9 | COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL325818 | 110157 | 0 | None | 6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.9 | COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12 | 10.1016/s0960-894x(03)00678-4 | ||
10895106 | 32011 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
CHEMBL140968 | 32011 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 9 | 1 | 6 | 3.1 | COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1021/jm025558r | ||
72164182 | 91718 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl | 10.1016/j.bmcl.2013.07.033 | ||
CHEMBL2420777 | 91718 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl | 10.1016/j.bmcl.2013.07.033 | ||
25072946 | 111292 | 0 | None | -12 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2c(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cccc12 | 10.1021/jm5004039 | ||
CHEMBL3287400 | 111292 | 0 | None | -12 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cnn2c(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cccc12 | 10.1021/jm5004039 | ||
44405530 | 140781 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 446 | 6 | 1 | 4 | 5.3 | O=C(N[C@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
CHEMBL383383 | 140781 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 446 | 6 | 1 | 4 | 5.3 | O=C(N[C@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C1)c1ccc(-c2cccs2)cc1 | 10.1016/j.bmcl.2005.08.051 | ||
56837419 | 68962 | 0 | None | -338 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 997 | 35 | 2 | 14 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928128 | 68962 | 0 | None | -338 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 997 | 35 | 2 | 14 | 6.2 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
15888352 | 123594 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.7 | CN1C(=O)c2ccccc2C1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL36337 | 123594 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 369 | 4 | 0 | 3 | 3.7 | CN1C(=O)c2ccccc2C1CCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(98)00252-2 | ||
90644066 | 111548 | 0 | None | 17 | 4 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 354 | 5 | 0 | 3 | 4.8 | Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL3289653 | 111548 | 0 | None | 17 | 4 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 354 | 5 | 0 | 3 | 4.8 | Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
5280343 | 187691 | 119 | None | 1 | 32 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/np1000329 | ||
CHEMBL1520590 | 187691 | 119 | None | 1 | 32 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/np1000329 | ||
CHEMBL50 | 187691 | 119 | None | 1 | 32 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/np1000329 | ||
44591086 | 188990 | 0 | None | -61 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 3 | 2 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1c[nH]c2ncccc12 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL514590 | 188990 | 0 | None | -61 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 3 | 2 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1c[nH]c2ncccc12 | 10.1016/j.bmc.2008.12.054 | ||
44395709 | 174326 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL456429 | 174326 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
CHEMBL556361 | 174326 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2004.09.046 | ||
44395709 | 174326 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL456429 | 174326 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL556361 | 174326 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.12.054 | ||
44436302 | 90203 | 0 | None | -1 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 429 | 7 | 0 | 6 | 2.4 | COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmcl.2021.128028 | ||
CHEMBL238917 | 90203 | 0 | None | -1 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 429 | 7 | 0 | 6 | 2.4 | COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmcl.2021.128028 | ||
44273896 | 99015 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 3.4 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccccc2Cl)CC1 | 10.1016/0960-894X(96)00198-9 | ||
CHEMBL283142 | 99015 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 3.4 | CC(C)(C)C(=O)NCCCCN1CCN(c2ccccc2Cl)CC1 | 10.1016/0960-894X(96)00198-9 | ||
9888211 | 21216 | 9 | None | -100 | 10 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 4.5 | O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 | 10.1021/jm070516u | ||
CHEMBL131495 | 21216 | 9 | None | -100 | 10 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 4.5 | O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 | 10.1021/jm070516u | ||
11347425 | 203409 | 3 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
CHEMBL77850 | 203409 | 3 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1 | 10.1021/jm0305669 | ||
12997412 | 9102 | 0 | None | -1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 411 | 6 | 1 | 3 | 4.2 | O=C(NCCCN1CCN(c2ccccc2)CC1)c1cccc2c1Cc1ccccc1-2 | 10.1021/jm010146o | ||
CHEMBL110349 | 9102 | 0 | None | -1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 411 | 6 | 1 | 3 | 4.2 | O=C(NCCCN1CCN(c2ccccc2)CC1)c1cccc2c1Cc1ccccc1-2 | 10.1021/jm010146o | ||
11168182 | 3478 | 18 | None | -125 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 511 | 14 | 1 | 3 | 6.5 | CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C | 10.1016/j.bmcl.2005.06.024 | ||
264 | 3478 | 18 | None | -125 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 511 | 14 | 1 | 3 | 6.5 | CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C | 10.1016/j.bmcl.2005.06.024 | ||
CHEMBL1181770 | 3478 | 18 | None | -125 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 511 | 14 | 1 | 3 | 6.5 | CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C | 10.1016/j.bmcl.2005.06.024 | ||
57326584 | 73717 | 0 | None | -8 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 396 | 1 | 0 | 5 | 4.9 | Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2 | 10.1021/jm2013419 | ||
CHEMBL2022273 | 73717 | 0 | None | -8 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 396 | 1 | 0 | 5 | 4.9 | Clc1ccc2c(c1)N=C(N1CCN(C3CCCCC3)CC1)c1cccnc1O2 | 10.1021/jm2013419 | ||
44394618 | 65860 | 0 | None | 15 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 374 | 5 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
CHEMBL184388 | 65860 | 0 | None | 15 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 374 | 5 | 1 | 2 | 4.5 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2004.07.045 | ||
44335918 | 5068 | 0 | None | 61 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 5 | 0 | 5 | 2.2 | COC(=O)[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL105745 | 5068 | 0 | None | 61 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 5 | 0 | 5 | 2.2 | COC(=O)[C@@H]1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(C)cc2)CC1 | 10.1016/s0960-894x(02)00656-x | ||
233952 | 198017 | 14 | None | 15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 291 | 3 | 1 | 2 | 3.5 | c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm9600712 | ||
CHEMBL59324 | 198017 | 14 | None | 15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 291 | 3 | 1 | 2 | 3.5 | c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm9600712 | ||
44335876 | 4987 | 0 | None | 15 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 377 | 4 | 0 | 3 | 3.4 | Cc1ccc(C)c(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)c1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL105304 | 4987 | 0 | None | 15 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 377 | 4 | 0 | 3 | 3.4 | Cc1ccc(C)c(CN2CCN(CC(=O)N3c4ccccc4CC3C)CC2)c1 | 10.1016/s0960-894x(02)00655-8 | ||
44336314 | 109153 | 0 | None | 204 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 3.0 | O=C1Cc2ccccc2N1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL322326 | 109153 | 0 | None | 204 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 3.0 | O=C1Cc2ccccc2N1CCN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
233952 | 198017 | 14 | None | 15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 291 | 3 | 1 | 2 | 3.5 | c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm0002432 | ||
CHEMBL59324 | 198017 | 14 | None | 15 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 291 | 3 | 1 | 2 | 3.5 | c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/jm0002432 | ||
11739255 | 79608 | 0 | None | 8 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
CHEMBL212861 | 79608 | 0 | None | 8 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 338 | 6 | 0 | 5 | 3.0 | CO/N=C(\CCN1CCN(c2ccccn2)CC1)c1cccc(C)c1 | 10.1021/jm060279f | ||
10425450 | 199 | 23 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/jm060662k | ||
3301 | 199 | 23 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/jm060662k | ||
CHEMBL375596 | 199 | 23 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 10.1021/jm060662k | ||
15840856 | 99368 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 358 | 5 | 0 | 3 | 4.7 | COc1ccccc1N1CCN(Cc2cccc(-c3ccccc3)c2)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
CHEMBL285577 | 99368 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 358 | 5 | 0 | 3 | 4.7 | COc1ccccc1N1CCN(Cc2cccc(-c3ccccc3)c2)CC1 | 10.1016/S0960-894X(97)00218-7 | ||
44436596 | 91564 | 0 | None | 3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 3.5 | C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
CHEMBL241631 | 91564 | 0 | None | 3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 3.5 | C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1 | 10.1016/j.bmc.2007.08.038 | ||
10359736 | 99053 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 3.0 | CCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm981041x | ||
CHEMBL283353 | 99053 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 3.0 | CCC(C)(C)C(=O)NCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm981041x | ||
137655735 | 158446 | 0 | None | -11 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 436 | 8 | 2 | 8 | 2.7 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4096353 | 158446 | 0 | None | -11 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 436 | 8 | 2 | 8 | 2.7 | COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1 | 10.1021/acs.jmedchem.6b01857 | ||
22100943 | 102660 | 0 | None | 41 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1cccc(CN2CC=C(c3nc4ccccc4s3)CC2)c1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL307869 | 102660 | 0 | None | 41 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1cccc(CN2CC=C(c3nc4ccccc4s3)CC2)c1 | 10.1016/S0960-894X(97)00402-2 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm0503805 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/jm049269+ | ||
91864602 | 140207 | 0 | None | -7 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818047 | 140207 | 0 | None | -7 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
10318141 | 205361 | 0 | None | 120 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 389 | 3 | 0 | 4 | 4.4 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(C(F)(F)F)cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL91938 | 205361 | 0 | None | 120 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 389 | 3 | 0 | 4 | 4.4 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(C(F)(F)F)cc1)CC3 | 10.1021/jm970170v | ||
12888943 | 9478 | 0 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
CHEMBL112395 | 9478 | 0 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl | 10.1016/s0960-894x(03)00678-4 | ||
137640189 | 156411 | 0 | None | -10 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 466 | 7 | 3 | 7 | 2.6 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4072780 | 156411 | 0 | None | -10 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 466 | 7 | 3 | 7 | 2.6 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
10737474 | 100883 | 0 | None | 10 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL296953 | 100883 | 0 | None | 10 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 363 | 4 | 1 | 3 | 3.5 | O=C(NCN1CCN(c2ccccc2Cl)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2005.02.012 | ||
53363199 | 63521 | 0 | None | 10 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 481 | 12 | 0 | 9 | 3.2 | CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
CHEMBL1803051 | 63521 | 0 | None | 10 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 481 | 12 | 0 | 9 | 3.2 | CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2004859 | ||
22100957 | 202563 | 4 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 358 | 3 | 0 | 3 | 5.4 | Clc1ccc(CN2CC=C(c3nc4cc(Cl)ccc4o3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL71208 | 202563 | 4 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 358 | 3 | 0 | 3 | 5.4 | Clc1ccc(CN2CC=C(c3nc4cc(Cl)ccc4o3)CC2)cc1 | 10.1016/S0960-894X(97)00402-2 | ||
10620139 | 205047 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 385 | 4 | 0 | 5 | 4.0 | COc1cc2oc(=O)c3c(c2cc1OC)CCN(Cc1ccc(Cl)cc1)C3 | 10.1021/jm970170v | ||
CHEMBL90173 | 205047 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 385 | 4 | 0 | 5 | 4.0 | COc1cc2oc(=O)c3c(c2cc1OC)CCN(Cc1ccc(Cl)cc1)C3 | 10.1021/jm970170v | ||
9945233 | 203383 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
CHEMBL77563 | 203383 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 | 10.1021/jm0305669 | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1016/s0960-894x(02)00390-6 | ||
2812861 | 206699 | 5 | None | 177 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.8 | c1ccc(-c2nc(CN3CCN(c4ccccn4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
CHEMBL99967 | 206699 | 5 | None | 177 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.8 | c1ccc(-c2nc(CN3CCN(c4ccccn4)CC3)c[nH]2)cc1 | 10.1021/jm960637m | ||
10324985 | 76428 | 7 | None | -6 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 1.7 | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 | 10.1021/jm050725j | ||
CHEMBL199824 | 76428 | 7 | None | -6 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 1.7 | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 | 10.1021/jm050725j | ||
CHEMBL2068762 | 76428 | 7 | None | -6 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 1.7 | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 | 10.1021/jm050725j | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm5004039 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm5004039 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm5004039 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmc.2016.04.028 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1016/j.bmc.2016.04.028 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm400520c | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm400520c | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm400520c | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm501889t | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm501889t | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 10.1021/jm501889t | ||
44284013 | 138700 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | OCc1ccc(N2CCN(CC[C@H](O)c3ccc(Cl)cc3)CC2)cc1Cl | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL37885 | 138700 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | OCc1ccc(N2CCN(CC[C@H](O)c3ccc(Cl)cc3)CC2)cc1Cl | 10.1016/s0960-894x(98)00252-2 | ||
10450880 | 205435 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 355 | 3 | 0 | 4 | 4.0 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(Cl)cc1)CC3 | 10.1021/jm970170v | ||
CHEMBL92373 | 205435 | 0 | None | 316 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 355 | 3 | 0 | 4 | 4.0 | COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(Cl)cc1)CC3 | 10.1021/jm970170v | ||
10685891 | 11492 | 1 | None | -7 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CC[C@H](CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
CHEMBL1180627 | 11492 | 1 | None | -7 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CC[C@H](CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
CHEMBL135357 | 11492 | 1 | None | -7 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 303 | 4 | 2 | 3 | 3.5 | Oc1cc2c(cc1Cl)CC[C@H](CNCc1ccccc1)O2 | 10.1021/jm9703653 | ||
3645619 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm970021c | ||
975 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm970021c | ||
CHEMBL45244 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1021/jm970021c | ||
57401820 | 69818 | 0 | None | 6 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 364 | 6 | 0 | 3 | 4.8 | Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940409 | 69818 | 0 | None | 6 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 364 | 6 | 0 | 3 | 4.8 | Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57401820 | 69818 | 0 | None | 6 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 364 | 6 | 0 | 3 | 4.8 | Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940409 | 69818 | 0 | None | 6 | 7 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 364 | 6 | 0 | 3 | 4.8 | Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
118709175 | 112924 | 0 | None | -4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 474 | 10 | 0 | 5 | 4.9 | CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318848 | 112924 | 0 | None | -4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 474 | 10 | 0 | 5 | 4.9 | CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
3645619 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/j.bmcl.2005.02.012 | ||
975 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/j.bmcl.2005.02.012 | ||
CHEMBL45244 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/j.bmcl.2005.02.012 | ||
44323780 | 112083 | 0 | None | 20 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 3.2 | O=C1Cc2c(ccc(Cl)c2N2CCN(Cc3ccccc3)CC2)N1 | 10.1016/s0960-894x(98)00474-0 | ||
CHEMBL330108 | 112083 | 0 | None | 20 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 3.2 | O=C1Cc2c(ccc(Cl)c2N2CCN(Cc3ccccc3)CC2)N1 | 10.1016/s0960-894x(98)00474-0 | ||
44323780 | 112083 | 0 | None | 20 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 3.2 | O=C1Cc2c(ccc(Cl)c2N2CCN(Cc3ccccc3)CC2)N1 | 10.1007/s00044-012-0055-5 | ||
CHEMBL330108 | 112083 | 0 | None | 20 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 3.2 | O=C1Cc2c(ccc(Cl)c2N2CCN(Cc3ccccc3)CC2)N1 | 10.1007/s00044-012-0055-5 | ||
44222483 | 194577 | 0 | None | -2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 3.0 | CSc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
CHEMBL561763 | 194577 | 0 | None | -2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 3.0 | CSc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1 | 10.1021/jm900690y | ||
9819770 | 140554 | 6 | None | 208 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL38262 | 140554 | 6 | None | 208 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.3 | Cc1ccc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
137653577 | 158327 | 0 | None | 208 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.6 | Cc1ccc(N2CCN(CCC3C(=O)Nc4ccccc43)CC2)cc1C | 10.1021/acs.jmedchem.7b00151 | ||
CHEMBL4095082 | 158327 | 0 | None | 208 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 3.6 | Cc1ccc(N2CCN(CCC3C(=O)Nc4ccccc43)CC2)cc1C | 10.1021/acs.jmedchem.7b00151 | ||
44360992 | 118899 | 0 | None | 2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1 | 10.1021/jm025558r | ||
CHEMBL344677 | 118899 | 0 | None | 2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1 | 10.1021/jm025558r | ||
228 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
33 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
6005 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
CHEMBL53 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
DB00714 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1021/jm060662k | ||
13091359 | 113040 | 0 | None | -12 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL3321790 | 113040 | 0 | None | -12 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/j.bmc.2013.01.065 | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/j.bmc.2013.01.065 | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/j.bmc.2013.01.065 | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/j.bmc.2013.01.065 | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/j.bmc.2013.01.065 | ||
44360992 | 118899 | 0 | None | 2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1 | 10.1021/jm0611152 | ||
CHEMBL344677 | 118899 | 0 | None | 2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1 | 10.1021/jm0611152 | ||
11776546 | 201545 | 1 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1cccc(OCCNCc2ccccc2)c1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL64508 | 201545 | 1 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1cccc(OCCNCc2ccccc2)c1 | 10.1016/s0960-894x(98)00014-6 | ||
11776546 | 201545 | 1 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1cccc(OCCNCc2ccccc2)c1 | 10.1016/s0960-894x(99)00434-5 | ||
CHEMBL64508 | 201545 | 1 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 243 | 6 | 2 | 3 | 2.6 | Oc1cccc(OCCNCc2ccccc2)c1 | 10.1016/s0960-894x(99)00434-5 | ||
10392655 | 198581 | 0 | None | -389 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.1 | COc1cc(Br)cc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1OC | 10.1016/j.bmcl.2003.09.083 | ||
CHEMBL59713 | 198581 | 0 | None | -389 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.1 | COc1cc(Br)cc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1OC | 10.1016/j.bmcl.2003.09.083 | ||
10392655 | 198581 | 0 | None | -389 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.1 | COc1cc(Br)cc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1OC | 10.1021/jm301545c | ||
CHEMBL59713 | 198581 | 0 | None | -389 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.1 | COc1cc(Br)cc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1OC | 10.1021/jm301545c | ||
72205046 | 91515 | 0 | None | -8 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | Clc1ccc(-n2cc(CCCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
CHEMBL2414357 | 91515 | 0 | None | -8 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.7 | Clc1ccc(-n2cc(CCCCN3CCN(c4ccccc4)CC3)cn2)cc1 | 10.1016/j.ejmech.2013.05.027 | ||
122177643 | 120698 | 0 | None | -501 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 632 | 20 | 3 | 9 | 5.1 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 | 10.1021/jm501889t | ||
CHEMBL3577344 | 120698 | 0 | None | -501 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 632 | 20 | 3 | 9 | 5.1 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 | 10.1021/jm501889t | ||
11452692 | 58604 | 0 | None | -338 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 413 | 10 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1 | 10.1021/jm101323b | ||
CHEMBL1688991 | 58604 | 0 | None | -338 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 413 | 10 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1 | 10.1021/jm101323b | ||
11452692 | 58604 | 0 | None | -338 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 413 | 10 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL1688991 | 58604 | 0 | None | -338 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 413 | 10 | 1 | 4 | 3.5 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
155512662 | 169088 | 2 | None | -1621 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 4.6 | N#Cc1cccc(N2CCN(CCCCNC(=O)c3ccc(-c4ccsc4)cc3)CC2)c1 | 10.1016/j.bmcl.2019.07.020 | ||
CHEMBL4437341 | 169088 | 2 | None | -1621 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 4.6 | N#Cc1cccc(N2CCN(CCCCNC(=O)c3ccc(-c4ccsc4)cc3)CC2)c1 | 10.1016/j.bmcl.2019.07.020 | ||
71456890 | 81415 | 0 | None | -50 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 4.7 | O=C(c1ccc2ccccc2c1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164351 | 81415 | 0 | None | -50 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 4.7 | O=C(c1ccc2ccccc2c1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
44415689 | 138579 | 0 | None | -912 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 494 | 2 | 2 | 6 | 4.7 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL378669 | 138579 | 0 | None | -912 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 494 | 2 | 2 | 6 | 4.7 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
44336004 | 5361 | 0 | None | 23 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 439 | 4 | 0 | 3 | 5.1 | Cc1ccc2c(c1)N(C(=O)CN1CCN(Cc3ccc(Cl)cc3)CC1)C(C)(C)CC2C | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL107338 | 5361 | 0 | None | 23 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 439 | 4 | 0 | 3 | 5.1 | Cc1ccc2c(c1)N(C(=O)CN1CCN(Cc3ccc(Cl)cc3)CC1)C(C)(C)CC2C | 10.1016/s0960-894x(02)00655-8 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm5004039 | ||
242 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.6b01857 | ||
34 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.6b01857 | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.6b01857 | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.6b01857 | ||
72737767 | 114022 | 4 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
CHEMBL3335540 | 114022 | 4 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(CN2CCOC(CCc3ccccc3)C2)cc1 | 10.1021/ml500267c | ||
134144304 | 153956 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3952251 | 153956 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990525 | 153956 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
44283963 | 139657 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | OCc1ccc(N2CCN(CC[C@@H](O)c3ccc(Cl)cc3)CC2)cc1Cl | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL38046 | 139657 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | OCc1ccc(N2CCN(CC[C@@H](O)c3ccc(Cl)cc3)CC2)cc1Cl | 10.1016/s0960-894x(98)00252-2 | ||
2274 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
4917 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
7279 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
CHEMBL728 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
DB00433 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
154705015 | 175940 | 1 | None | -186 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4454380 | 175940 | 1 | None | -186 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596929 | 175940 | 1 | None | -186 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
71062829 | 159587 | 0 | None | -1 | 3 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 6 | 0 | 5 | 2.2 | c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1 | nan | ||
CHEMBL4108986 | 159587 | 0 | None | -1 | 3 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 6 | 0 | 5 | 2.2 | c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1 | nan | ||
44591043 | 176238 | 0 | None | 3 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 326 | 3 | 2 | 2 | 3.9 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmc.2008.12.054 | ||
CHEMBL460855 | 176238 | 0 | None | 3 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 326 | 3 | 2 | 2 | 3.9 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmc.2008.12.054 | ||
130431343 | 173944 | 0 | None | -2454 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 439 | 8 | 1 | 5 | 3.9 | CCc1cccc(N2CCN(CCCCNC(=O)c3cn4ccccc4n3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4555307 | 173944 | 0 | None | -2454 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 439 | 8 | 1 | 5 | 3.9 | CCc1cccc(N2CCN(CCCCNC(=O)c3cn4ccccc4n3)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
44454685 | 94610 | 0 | None | 7 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.0 | FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1016/j.bmcl.2007.12.026 | ||
CHEMBL255163 | 94610 | 0 | None | 7 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 4.0 | FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1 | 10.1016/j.bmcl.2007.12.026 | ||
134144304 | 153956 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3952251 | 153956 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
CHEMBL3990525 | 153956 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 327 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.09.019 | ||
57391895 | 68959 | 0 | None | -42 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 925 | 30 | 2 | 13 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
CHEMBL1928125 | 68959 | 0 | None | -42 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 925 | 30 | 2 | 13 | 5.4 | COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1 | 10.1016/j.bmc.2011.10.063 | ||
155513053 | 169131 | 0 | None | 6 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4437912 | 169131 | 0 | None | 6 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CCc1cccc(NC(=O)CN2CCC(c3ccccn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
11405107 | 197385 | 0 | None | 7 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 3 | 1 | 2 | 3.7 | C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1 | 10.1016/s0960-894x(02)00316-5 | ||
CHEMBL58662 | 197385 | 0 | None | 7 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 3 | 1 | 2 | 3.7 | C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1 | 10.1016/s0960-894x(02)00316-5 | ||
11808247 | 17891 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL126667 | 17891 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819366 | 17891 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
11314005 | 109045 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 346 | 5 | 0 | 4 | 3.7 | Cc1ncccc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL322175 | 109045 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 346 | 5 | 0 | 4 | 3.7 | Cc1ncccc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
162645252 | 183043 | 0 | None | -1 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4743284 | 183043 | 0 | None | -1 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4802393 | 183043 | 0 | None | -1 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
11808247 | 17891 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL126667 | 17891 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3819366 | 17891 | 0 | None | 1 | 9 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
10961938 | 119034 | 0 | None | -1380 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 5.5 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2ccccc12 | 10.1021/jm050171k | ||
CHEMBL345820 | 119034 | 0 | None | -1380 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 5.5 | COc1c(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2ccccc12 | 10.1021/jm050171k | ||
71658207 | 89977 | 0 | None | -46 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 3.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Br)nc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
CHEMBL2386621 | 89977 | 0 | None | -46 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 3.6 | COc1ccccc1N1CCCN(CCCCNC(=O)c2ccc(Br)nc2)CC1 | 10.1016/j.bmc.2013.03.074 | ||
4209 | 3114 | 71 | None | -1318 | 33 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1021/jm020938y | ||
4893 | 3114 | 71 | None | -1318 | 33 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1021/jm020938y | ||
503 | 3114 | 71 | None | -1318 | 33 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1021/jm020938y | ||
5385 | 3114 | 71 | None | -1318 | 33 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1021/jm020938y | ||
CHEMBL2 | 3114 | 71 | None | -1318 | 33 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1021/jm020938y | ||
DB00457 | 3114 | 71 | None | -1318 | 33 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1021/jm020938y | ||
127052486 | 140292 | 0 | None | -8 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 424 | 6 | 1 | 5 | 4.8 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819153 | 140292 | 0 | None | -8 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 424 | 6 | 1 | 5 | 4.8 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
46231926 | 198895 | 0 | None | -41686 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 446 | 4 | 1 | 4 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
CHEMBL599135 | 198895 | 0 | None | -41686 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 446 | 4 | 1 | 4 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | ||
10689266 | 205315 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 4 | 0 | 5 | 3.4 | COc1ccc(CN2CCc3c(c(=O)oc4cc(OC)ccc34)C2)cc1 | 10.1021/jm970170v | ||
CHEMBL91658 | 205315 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 351 | 4 | 0 | 5 | 3.4 | COc1ccc(CN2CCc3c(c(=O)oc4cc(OC)ccc34)C2)cc1 | 10.1021/jm970170v | ||
162645252 | 183043 | 0 | None | -1 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4743284 | 183043 | 0 | None | -1 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
CHEMBL4802393 | 183043 | 0 | None | -1 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 389 | 7 | 0 | 3 | 5.0 | Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1 | 10.1016/j.bmc.2020.115943 | ||
56649649 | 67515 | 0 | None | -97 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 480 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 | 10.1016/j.ejmech.2011.06.023 | ||
CHEMBL1910140 | 67515 | 0 | None | -97 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 480 | 8 | 0 | 5 | 4.6 | COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 | 10.1016/j.ejmech.2011.06.023 | ||
44431483 | 167084 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL430167 | 167084 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.12.106 | ||
137655451 | 158307 | 0 | None | -6 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
CHEMBL4094869 | 158307 | 0 | None | -6 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 393 | 9 | 1 | 5 | 4.5 | CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1 | 10.1021/acs.jmedchem.6b01857 | ||
56833463 | 67994 | 0 | None | -41 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 578 | 17 | 1 | 9 | 4.4 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2009919 | ||
CHEMBL1916552 | 67994 | 0 | None | -41 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 578 | 17 | 1 | 9 | 4.4 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1 | 10.1021/jm2009919 | ||
11783703 | 40793 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 1 | 1 | 5 | 4.5 | Cc1ccc2c(c1)C(N1CCN(C3CCCCC3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL148752 | 40793 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 1 | 1 | 5 | 4.5 | Cc1ccc2c(c1)C(N1CCN(C3CCCCC3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
11560697 | 10510 | 0 | None | -363 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 414 | 4 | 2 | 3 | 4.4 | COc1cccc2[nH]cc(CN3CCC(O)(c4ccc(Br)cc4)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1170095 | 10510 | 0 | None | -363 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 414 | 4 | 2 | 3 | 4.4 | COc1cccc2[nH]cc(CN3CCC(O)(c4ccc(Br)cc4)CC3)c12 | 10.1016/j.bmc.2010.05.052 | ||
127052486 | 140292 | 0 | None | -8 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 424 | 6 | 1 | 5 | 4.8 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
CHEMBL3819153 | 140292 | 0 | None | -8 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 424 | 6 | 1 | 5 | 4.8 | O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1 | 10.1016/j.bmc.2016.06.011 | ||
154705128 | 175717 | 1 | None | -58 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 12 | 1 | 3 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4454872 | 175717 | 1 | None | -58 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 12 | 1 | 3 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595148 | 175717 | 1 | None | -58 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 12 | 1 | 3 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL5079903 | 212879 | 0 | None | -32 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | None | None | None | N#CC(CCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.1c00611 | ||||
154724609 | 176025 | 1 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 10 | 0 | 6 | 4.8 | COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4514800 | 176025 | 1 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 10 | 0 | 6 | 4.8 | COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597637 | 176025 | 1 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 10 | 0 | 6 | 4.8 | COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
154726922 | 175967 | 1 | None | 1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4442936 | 175967 | 1 | None | 1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597157 | 175967 | 1 | None | 1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
118709171 | 112919 | 0 | None | -2 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1085 | 35 | 0 | 8 | 16.8 | O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318843 | 112919 | 0 | None | -2 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1085 | 35 | 0 | 8 | 16.8 | O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
45483655 | 196438 | 0 | None | -12 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1047 | 23 | 2 | 14 | 8.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1 | 10.1021/jm901120h | ||
CHEMBL574534 | 196438 | 0 | None | -12 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1047 | 23 | 2 | 14 | 8.6 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1 | 10.1021/jm901120h | ||
11151135 | 108929 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 313 | 6 | 0 | 4 | 3.0 | COc1ccccc1OCC1CN(Cc2ccccc2)CCO1 | 10.1021/jm031111m | ||
CHEMBL322002 | 108929 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 313 | 6 | 0 | 4 | 3.0 | COc1ccccc1OCC1CN(Cc2ccccc2)CCO1 | 10.1021/jm031111m | ||
154706123 | 175714 | 1 | None | -107 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4593394 | 175714 | 1 | None | -107 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595145 | 175714 | 1 | None | -107 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 489 | 13 | 1 | 4 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
127035062 | 135928 | 0 | None | -29 | 19 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 447 | 12 | 0 | 5 | 5.2 | COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC | 10.1039/C4MD00418C | ||
CHEMBL3735756 | 135928 | 0 | None | -29 | 19 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 447 | 12 | 0 | 5 | 5.2 | COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC | 10.1039/C4MD00418C | ||
91864602 | 140207 | 0 | None | -7 | 8 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
CHEMBL3818047 | 140207 | 0 | None | -7 | 8 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
168286314 | 191063 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5196213 | 191063 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 389 | 5 | 1 | 3 | 4.8 | FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]ncc4c3)CC2)c1 | 10.1016/j.bmcl.2022.128615 | ||
56681925 | 66034 | 0 | None | -2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 3.5 | CN1CN(c2ccccc2)C2(CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)C1=O | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1813589 | 66034 | 0 | None | -2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 3.5 | CN1CN(c2ccccc2)C2(CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)C1=O | 10.1016/j.bmc.2011.04.021 | ||
CHEMBL1851628 | 66034 | 0 | None | -2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 3.5 | CN1CN(c2ccccc2)C2(CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)C1=O | 10.1016/j.bmc.2011.04.021 | ||
44338149 | 109848 | 0 | None | -4 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 575 | 10 | 0 | 3 | 8.2 | Fc1ccc(C(OCCN2C3CCC2CC(OC(c2ccc(F)cc2)c2ccc(F)cc2)C3)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
CHEMBL323997 | 109848 | 0 | None | -4 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 575 | 10 | 0 | 3 | 8.2 | Fc1ccc(C(OCCN2C3CCC2CC(OC(c2ccc(F)cc2)c2ccc(F)cc2)C3)c2ccc(F)cc2)cc1 | 10.1021/jm010146o | ||
44360984 | 34855 | 0 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1 | 10.1021/jm025558r | ||
CHEMBL143352 | 34855 | 0 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1 | 10.1021/jm025558r | ||
44316315 | 203808 | 0 | None | -5 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 215 | 2 | 0 | 3 | 2.1 | CCCN1CCc2nn3ccccc3c2C1 | 10.1016/s0960-894x(02)00390-6 | ||
CHEMBL80845 | 203808 | 0 | None | -5 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 215 | 2 | 0 | 3 | 2.1 | CCCN1CCc2nn3ccccc3c2C1 | 10.1016/s0960-894x(02)00390-6 | ||
10623982 | 205323 | 0 | None | 2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 463 | 7 | 2 | 4 | 4.6 | COc1cc(NC(=O)c2ccccc2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
CHEMBL91693 | 205323 | 0 | None | 2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 463 | 7 | 2 | 4 | 4.6 | COc1cc(NC(=O)c2ccccc2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1 | 10.1021/jm9601720 | ||
22100965 | 202065 | 4 | None | 16 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1ccccc1CN1CC=C(c2nc3ccccc3s2)CC1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL67982 | 202065 | 4 | None | 16 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Clc1ccccc1CN1CC=C(c2nc3ccccc3s2)CC1 | 10.1016/S0960-894X(97)00402-2 | ||
44372154 | 53940 | 0 | None | 11 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 5.4 | Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
CHEMBL160749 | 53940 | 0 | None | 11 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 5.4 | Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00814-9 | ||
44360984 | 34855 | 0 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1 | 10.1021/jm0611152 | ||
CHEMBL143352 | 34855 | 0 | None | -7 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1 | 10.1021/jm0611152 | ||
16007117 | 79626 | 0 | None | -870 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 479 | 2 | 1 | 5 | 5.1 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL212912 | 79626 | 0 | None | -870 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 479 | 2 | 1 | 5 | 5.1 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
137660707 | 158752 | 0 | None | -281 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 3.4 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5oc(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4099666 | 158752 | 0 | None | -281 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 463 | 7 | 2 | 7 | 3.4 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5oc(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
118719795 | 115222 | 0 | None | -234 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 442 | 8 | 0 | 7 | 4.0 | COc1ccccc1N1CCN(CCCCc2cn(-c3cccc4cnccc34)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353898 | 115222 | 0 | None | -234 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 442 | 8 | 0 | 7 | 4.0 | COc1ccccc1N1CCN(CCCCc2cn(-c3cccc4cnccc34)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
154725749 | 176114 | 1 | None | -79 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4453478 | 176114 | 1 | None | -79 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4598388 | 176114 | 1 | None | -79 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | ||
11849229 | 137646 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 349 | 7 | 0 | 6 | 2.5 | N#CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
CHEMBL376955 | 137646 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 349 | 7 | 0 | 6 | 2.5 | N#CCO/N=C(\CCN1CCN(c2ccccn2)CC1)c1ccccc1 | 10.1021/jm060279f | ||
22727347 | 12920 | 0 | None | -5 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 9 | 0 | 5 | 5.0 | COc1ccccc1N1CCN(CCCCc2cc(/C=C/c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1189897 | 12920 | 0 | None | -5 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 9 | 0 | 5 | 5.0 | COc1ccccc1N1CCN(CCCCc2cc(/C=C/c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL539744 | 12920 | 0 | None | -5 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 9 | 0 | 5 | 5.0 | COc1ccccc1N1CCN(CCCCc2cc(/C=C/c3ccccc3)no2)CC1 | 10.1016/s0960-894x(02)00179-8 | ||
11775107 | 165663 | 0 | None | -26 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | ||
CHEMBL426629 | 165663 | 0 | None | -26 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | ||
863787 | 65959 | 13 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL184772 | 65959 | 13 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.8 | COc1ccc(N2CCN(CC(=O)Nc3cccc(C)c3)CC2)cc1 | 10.1016/j.bmcl.2004.07.068 | ||
164610259 | 184524 | 0 | None | -2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccccc1Br)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4856161 | 184524 | 0 | None | -2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccccc1Br)CC2 | 10.1016/j.bmcl.2021.128047 | ||
49782841 | 17470 | 0 | None | -549 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.1 | O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1 | 10.1021/jm100899z | ||
CHEMBL1258382 | 17470 | 0 | None | -549 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.1 | O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1 | 10.1021/jm100899z | ||
137642033 | 157599 | 0 | None | -147 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 291 | 3 | 2 | 5 | 1.3 | CCCN1CCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
CHEMBL4087217 | 157599 | 0 | None | -147 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 291 | 3 | 2 | 5 | 1.3 | CCCN1CCN(c2ccc(O)c3c2OCC(=O)N3)CC1 | 10.1016/j.bmc.2017.08.037 | ||
44438237 | 93226 | 2 | None | -47 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 424 | 8 | 1 | 3 | 6.4 | CCCCCCn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.10.076 | ||
CHEMBL246855 | 93226 | 2 | None | -47 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 424 | 8 | 1 | 3 | 6.4 | CCCCCCn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.10.076 | ||
127053222 | 138839 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3793072 | 138839 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 369 | 5 | 0 | 3 | 4.1 | Fc1ccc(CN2CCO[C@H](COc3ccccc3)C2)cc1C(F)(F)F | 10.1016/j.bmcl.2016.03.102 | ||
57398352 | 69819 | 0 | None | 6 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 398 | 6 | 0 | 3 | 5.1 | Fc1ccc(SCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940410 | 69819 | 0 | None | 6 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 398 | 6 | 0 | 3 | 5.1 | Fc1ccc(SCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
90644228 | 111294 | 0 | None | -14 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
CHEMBL3287402 | 111294 | 0 | None | -14 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 446 | 8 | 0 | 6 | 4.4 | O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
118709177 | 112926 | 0 | None | -17 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1135 | 31 | 0 | 14 | 12.5 | O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318850 | 112926 | 0 | None | -17 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1135 | 31 | 0 | 14 | 12.5 | O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
135442113 | 118487 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 3 | 2 | 5 | 5.1 | Clc1ccc2c(c1)C(NC1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
CHEMBL342536 | 118487 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 417 | 3 | 2 | 5 | 5.1 | Clc1ccc2c(c1)C(NC1CCN(Cc3ccccc3)CC1)=Nc1cccnc1N2 | 10.1021/jm0104825 | ||
155533824 | 171332 | 0 | None | -27 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 238 | 2 | 0 | 2 | 2.7 | CCc1cccc(N2CCN(C)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
CHEMBL4469777 | 171332 | 0 | None | -27 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 238 | 2 | 0 | 2 | 2.7 | CCc1cccc(N2CCN(C)CC2)c1Cl | 10.1021/acs.jmedchem.6b00860 | ||
51353676 | 59865 | 0 | None | -1380 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 442 | 11 | 1 | 5 | 3.4 | CN(C)c1ccc(C(=O)NCCCCN2CCN(c3ccccc3OCCF)CC2)cc1 | 10.1021/jm101323b | ||
CHEMBL1689002 | 59865 | 0 | None | -1380 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 442 | 11 | 1 | 5 | 3.4 | CN(C)c1ccc(C(=O)NCCCCN2CCN(c3ccccc3OCCF)CC2)cc1 | 10.1021/jm101323b | ||
CHEMBL1739784 | 59865 | 0 | None | -1380 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 442 | 11 | 1 | 5 | 3.4 | CN(C)c1ccc(C(=O)NCCCCN2CCN(c3ccccc3OCCF)CC2)cc1 | 10.1021/jm101323b | ||
51353992 | 59895 | 0 | None | -812 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 11 | 1 | 4 | 3.7 | O=C(NC/C=C/CN1CCN(c2ccccc2OCCF)CC1)c1ccc(CCF)cc1 | 10.1021/jm101323b | ||
CHEMBL1689009 | 59895 | 0 | None | -812 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 11 | 1 | 4 | 3.7 | O=C(NC/C=C/CN1CCN(c2ccccc2OCCF)CC1)c1ccc(CCF)cc1 | 10.1021/jm101323b | ||
CHEMBL1739965 | 59895 | 0 | None | -812 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 11 | 1 | 4 | 3.7 | O=C(NC/C=C/CN1CCN(c2ccccc2OCCF)CC1)c1ccc(CCF)cc1 | 10.1021/jm101323b | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm020952a | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm020952a | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm020952a | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
53248365 | 61757 | 0 | None | -933 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 554 | 6 | 1 | 5 | 2.9 | O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I | 10.1021/jm1009956 | ||
CHEMBL1774995 | 61757 | 0 | None | -933 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 554 | 6 | 1 | 5 | 2.9 | O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I | 10.1021/jm1009956 | ||
53326601 | 58603 | 0 | None | -1122 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 9 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1 | 10.1021/jm101323b | ||
CHEMBL1688990 | 58603 | 0 | None | -1122 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 9 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1 | 10.1021/jm101323b | ||
53326601 | 58603 | 0 | None | -1122 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 9 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL1688990 | 58603 | 0 | None | -1122 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 410 | 9 | 1 | 5 | 3.1 | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
135398737 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
38 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
722 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
CHEMBL42 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
DB00363 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm960084f | ||
3645619 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/s0960-894x(00)00633-8 | ||
975 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/s0960-894x(00)00633-8 | ||
CHEMBL45244 | 2985 | 13 | None | -4 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 10.1016/s0960-894x(00)00633-8 | ||
10950176 | 44758 | 1 | None | -33 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 435 | 8 | 1 | 4 | 4.3 | COc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
CHEMBL152391 | 44758 | 1 | None | -33 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 435 | 8 | 1 | 4 | 4.3 | COc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1 | 10.1021/jm020952a | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00655-8 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00655-8 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00655-8 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00655-8 | ||
155530733 | 171013 | 0 | None | 9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 477 | 9 | 2 | 5 | 3.9 | COc1ccccc1N1CCN(CCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4465002 | 171013 | 0 | None | 9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 477 | 9 | 2 | 5 | 3.9 | COc1ccccc1N1CCN(CCNC(=O)NN(Cc2ccccc2)c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
10158455 | 119465 | 0 | None | 15 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 409 | 3 | 0 | 3 | 3.8 | CC1Cc2cccc3c2N1C(=O)C(N1CCN(Cc2ccc(Cl)cc2)CC1)CC3 | 10.1016/s0960-894x(02)01056-9 | ||
CHEMBL349833 | 119465 | 0 | None | 15 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 409 | 3 | 0 | 3 | 3.8 | CC1Cc2cccc3c2N1C(=O)C(N1CCN(Cc2ccc(Cl)cc2)CC1)CC3 | 10.1016/s0960-894x(02)01056-9 | ||
10495652 | 36345 | 0 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 316 | 4 | 0 | 2 | 4.9 | c1ccc(C2CCN(Cc3ccn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm00025a013 | ||
CHEMBL144835 | 36345 | 0 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 316 | 4 | 0 | 2 | 4.9 | c1ccc(C2CCN(Cc3ccn(-c4ccccc4)c3)CC2)cc1 | 10.1021/jm00025a013 | ||
1613 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm2013419 | ||
205 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm2013419 | ||
3964 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm2013419 | ||
CHEMBL831 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm2013419 | ||
DB00408 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm2013419 | ||
163091 | 491 | 30 | None | -147 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 10.1039/C5MD00258C | ||
22 | 491 | 30 | None | -147 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 10.1039/C5MD00258C | ||
CHEMBL504548 | 491 | 30 | None | -147 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 10.1039/C5MD00258C | ||
10643780 | 118890 | 0 | None | 97 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 384 | 3 | 1 | 3 | 4.7 | N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1 | 10.1021/jm0009989 | ||
CHEMBL344602 | 118890 | 0 | None | 97 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 384 | 3 | 1 | 3 | 4.7 | N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1 | 10.1021/jm0009989 | ||
10594113 | 203202 | 1 | None | 13 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 351 | 4 | 1 | 2 | 5.1 | Clc1ccc(-c2cc(C3CCN(Cc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
CHEMBL76090 | 203202 | 1 | None | 13 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 351 | 4 | 1 | 2 | 5.1 | Clc1ccc(-c2cc(C3CCN(Cc4ccccc4)CC3)[nH]n2)cc1 | 10.1021/jm970111h | ||
11131951 | 49651 | 1 | None | -363 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 2.6 | COc1cccc(C(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1 | 10.1021/jm100925m | ||
CHEMBL156845 | 49651 | 1 | None | -363 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 2.6 | COc1cccc(C(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1 | 10.1021/jm100925m | ||
15467369 | 100461 | 0 | None | 562 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 4 | 2.8 | N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
CHEMBL293956 | 100461 | 0 | None | 562 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 317 | 4 | 1 | 4 | 2.8 | N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1 | 10.1016/s0960-894x(99)00302-9 | ||
90644230 | 111298 | 0 | None | -4 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 443 | 7 | 0 | 6 | 4.5 | N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
CHEMBL3287406 | 111298 | 0 | None | -4 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 443 | 7 | 0 | 6 | 4.5 | N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1 | 10.1021/jm5004039 | ||
23364995 | 112921 | 0 | None | -2 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 417 | 7 | 0 | 4 | 5.0 | CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
CHEMBL3318845 | 112921 | 0 | None | -2 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 417 | 7 | 0 | 4 | 5.0 | CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.06.079 | ||
11292776 | 5510 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 409 | 7 | 0 | 4 | 5.1 | CCOc1ccc(Cl)cc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
CHEMBL107691 | 5510 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 409 | 7 | 0 | 4 | 5.1 | CCOc1ccc(Cl)cc1OCC1CN(Cc2ccc(Cl)cc2)CCCO1 | 10.1021/jm031111m | ||
44283757 | 137337 | 0 | None | 128 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 348 | 4 | 1 | 2 | 4.4 | Cc1ccc(C2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
CHEMBL37604 | 137337 | 0 | None | 128 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 348 | 4 | 1 | 2 | 4.4 | Cc1ccc(C2CCN(CCC3NC(=O)c4ccccc43)CC2)cc1C | 10.1016/s0960-894x(98)00252-2 | ||
57345617 | 70113 | 0 | None | 1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
CHEMBL1946123 | 70113 | 0 | None | 1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
127028505 | 138803 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
CHEMBL3792731 | 138803 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 333 | 5 | 0 | 3 | 4.3 | Clc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1 | 10.1016/j.bmcl.2016.03.102 | ||
76518514 | 113038 | 0 | None | 1 | 9 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
CHEMBL3321788 | 113038 | 0 | None | 1 | 9 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
122177645 | 120700 | 0 | None | -44 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | ||
CHEMBL3577346 | 120700 | 0 | None | -44 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | ||
10356955 | 12879 | 0 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 291 | 1 | 0 | 2 | 4.7 | CN1CCC(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL1189601 | 12879 | 0 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 291 | 1 | 0 | 2 | 4.7 | CN1CCC(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
CHEMBL539057 | 12879 | 0 | None | -1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 291 | 1 | 0 | 2 | 4.7 | CN1CCC(C2=Cc3ccccc3Oc3ccccc32)CC1 | 10.1021/jm00004a016 | ||
57398351 | 69815 | 0 | None | 4 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 347 | 6 | 0 | 2 | 5.1 | Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
CHEMBL1940406 | 69815 | 0 | None | 4 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 347 | 6 | 0 | 2 | 5.1 | Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | ||
57398351 | 69815 | 0 | None | 4 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 347 | 6 | 0 | 2 | 5.1 | Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
CHEMBL1940406 | 69815 | 0 | None | 4 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 347 | 6 | 0 | 2 | 5.1 | Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
11504230 | 77840 | 0 | None | -12 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 497 | 8 | 1 | 4 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm060138d | ||
CHEMBL210567 | 77840 | 0 | None | -12 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 497 | 8 | 1 | 4 | 4.9 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1 | 10.1021/jm060138d | ||
71461481 | 83656 | 0 | None | 8 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 356 | 4 | 0 | 3 | 4.1 | C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2 | 10.1016/j.bmcl.2012.09.064 | ||
CHEMBL2207632 | 83656 | 0 | None | 8 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 356 | 4 | 0 | 3 | 4.1 | C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2 | 10.1016/j.bmcl.2012.09.064 | ||
76321556 | 105896 | 0 | None | 2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115578 | 105896 | 0 | None | 2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139302 | 105896 | 0 | None | 2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
2099556 | 203344 | 6 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm0305669 | ||
CHEMBL77151 | 203344 | 6 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 326 | 3 | 1 | 3 | 3.5 | Clc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 | 10.1021/jm0305669 | ||
155566403 | 175363 | 0 | None | 52 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 477 | 9 | 2 | 4 | 4.8 | O=C(NCCCN1CCN(c2ccc(Cl)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL4587645 | 175363 | 0 | None | 52 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 477 | 9 | 2 | 4 | 4.8 | O=C(NCCCN1CCN(c2ccc(Cl)cc2)CC1)NN(Cc1ccccc1)c1ccccc1 | 10.1021/acs.jmedchem.9b01085 | ||
76321556 | 105896 | 0 | None | 2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3115578 | 105896 | 0 | None | 2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
CHEMBL3139302 | 105896 | 0 | None | 2 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | ||
54585810 | 61275 | 0 | None | 1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 469 | 8 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
CHEMBL1771108 | 61275 | 0 | None | 1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 469 | 8 | 0 | 4 | 5.0 | COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1 | 10.1016/j.bmcl.2010.12.083 | ||
44403225 | 70204 | 0 | None | 5 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 2.7 | COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL194755 | 70204 | 0 | None | 5 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 2.7 | COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.07.037 | ||
9129986 | 4989 | 1 | None | 67 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 379 | 5 | 0 | 4 | 2.8 | COc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL105317 | 4989 | 1 | None | 67 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 379 | 5 | 0 | 4 | 2.8 | COc1ccc(CN2CCN(CC(=O)N3c4ccccc4C[C@H]3C)CC2)cc1 | 10.1016/s0960-894x(02)00656-x | ||
44412268 | 77964 | 8 | None | 47 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 2.6 | c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
CHEMBL211026 | 77964 | 8 | None | 47 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 319 | 4 | 0 | 5 | 2.6 | c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1 | 10.1016/j.bmcl.2006.02.075 | ||
25142456 | 81994 | 2 | None | -44 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 | 10.1021/jm0604979 | ||
CHEMBL217299 | 81994 | 2 | None | -44 | 9 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 | 10.1021/jm0604979 | ||
11849268 | 168232 | 0 | None | -4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(/CCN1CCC(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
CHEMBL437532 | 168232 | 0 | None | -4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 357 | 6 | 0 | 4 | 4.4 | CO/N=C(/CCN1CCC(c2ccccn2)CC1)c1ccc(Cl)cc1 | 10.1021/jm060279f | ||
118719797 | 115224 | 0 | None | -12 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 459 | 8 | 0 | 7 | 4.8 | COc1ccccc1N1CCN(CCCc2cn(-c3ccc(-c4ccsc4)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
CHEMBL3353900 | 115224 | 0 | None | -12 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 459 | 8 | 0 | 7 | 4.8 | COc1ccccc1N1CCN(CCCc2cn(-c3ccc(-c4ccsc4)cc3)nn2)CC1 | 10.1016/j.bmcl.2014.12.023 | ||
71086428 | 151021 | 0 | None | 66 | 2 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 6 | 0 | 5 | 2.9 | Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
CHEMBL3963122 | 151021 | 0 | None | 66 | 2 | Mouse | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 6 | 0 | 5 | 2.9 | Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | ||
8704110 | 66268 | 9 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 2.9 | Cc1cccc(NC(=O)CN2CCN(c3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL185263 | 66268 | 9 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 2.9 | Cc1cccc(NC(=O)CN2CCN(c3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2004.07.068 | ||
127698 | 115500 | 6 | None | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 329 | 4 | 0 | 1 | 5.7 | C1=C(c2ccccc2)CCN(C[C@@H]2CCC=C(c3ccccc3)C2)C1 | 10.1021/jm00026a007 | ||
CHEMBL335545 | 115500 | 6 | None | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 329 | 4 | 0 | 1 | 5.7 | C1=C(c2ccccc2)CCN(C[C@@H]2CCC=C(c3ccccc3)C2)C1 | 10.1021/jm00026a007 | ||
127698 | 115500 | 6 | None | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 329 | 4 | 0 | 1 | 5.7 | C1=C(c2ccccc2)CCN(C[C@@H]2CCC=C(c3ccccc3)C2)C1 | 10.1021/jm00047a010 | ||
CHEMBL335545 | 115500 | 6 | None | -6 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 329 | 4 | 0 | 1 | 5.7 | C1=C(c2ccccc2)CCN(C[C@@H]2CCC=C(c3ccccc3)C2)C1 | 10.1021/jm00047a010 | ||
127046949 | 139379 | 0 | None | -141 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 472 | 12 | 3 | 5 | 4.6 | COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3799455 | 139379 | 0 | None | -141 | 6 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 472 | 12 | 3 | 5 | 4.6 | COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00656-x | ||
38 | 944 | 89 | None | -13 | 91 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00656-x | ||
722 | 944 | 89 | None | -13 | 91 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00656-x | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00656-x | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/s0960-894x(02)00656-x | ||
11630058 | 140843 | 0 | None | -7 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 237 | 4 | 1 | 5 | 1.0 | CCCNC1CCn2ncc(C(=O)OC)c2C1 | 10.1021/jm0503805 | ||
CHEMBL383805 | 140843 | 0 | None | -7 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 237 | 4 | 1 | 5 | 1.0 | CCCNC1CCn2ncc(C(=O)OC)c2C1 | 10.1021/jm0503805 | ||
142590701 | 178941 | 0 | None | -1 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 484 | 8 | 1 | 3 | 5.8 | O=C(c1ccc(F)cc1)N1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4741279 | 178941 | 0 | None | -1 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 484 | 8 | 1 | 3 | 5.8 | O=C(c1ccc(F)cc1)N1CCC(NCCSC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.ejmech.2020.112674 | ||
132060720 | 161939 | 0 | None | -2 | 9 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 315 | 4 | 0 | 2 | 4.9 | COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1 | 10.1016/j.ejmech.2018.02.024 | ||
CHEMBL4167315 | 161939 | 0 | None | -2 | 9 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 315 | 4 | 0 | 2 | 4.9 | COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1 | 10.1016/j.ejmech.2018.02.024 | ||
11699516 | 141102 | 0 | None | -2 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 540 | 10 | 1 | 7 | 3.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1 | 10.1021/jm0611152 | ||
CHEMBL385289 | 141102 | 0 | None | -2 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 540 | 10 | 1 | 7 | 3.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1 | 10.1021/jm0611152 | ||
8690650 | 4699 | 4 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 268 | 3 | 1 | 3 | 2.7 | Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL103900 | 4699 | 4 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 268 | 3 | 1 | 3 | 2.7 | Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
154726381 | 175953 | 1 | None | -173 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4522558 | 175953 | 1 | None | -173 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597048 | 175953 | 1 | None | -173 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 509 | 12 | 1 | 3 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | ||
44269820 | 44787 | 0 | None | -2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 369 | 3 | 0 | 4 | 4.8 | CN1CCN(c2nc3ccccc3c(Cl)c2Sc2ccccc2)CC1 | 10.1016/s0960-894x(01)00167-6 | ||
CHEMBL15242 | 44787 | 0 | None | -2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 369 | 3 | 0 | 4 | 4.8 | CN1CCN(c2nc3ccccc3c(Cl)c2Sc2ccccc2)CC1 | 10.1016/s0960-894x(01)00167-6 | ||
56649650 | 67516 | 0 | None | -104 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 4.2 | COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 | 10.1016/j.ejmech.2011.06.023 | ||
CHEMBL1910141 | 67516 | 0 | None | -104 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 4.2 | COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 | 10.1016/j.ejmech.2011.06.023 | ||
9882594 | 109894 | 0 | None | -436 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 3.1 | COc1cccc2c1N1CCN(C)CC1c1ccccc1C2 | 10.1021/jm010566d | ||
CHEMBL324270 | 109894 | 0 | None | -436 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 294 | 1 | 0 | 3 | 3.1 | COc1cccc2c1N1CCN(C)CC1c1ccccc1C2 | 10.1021/jm010566d | ||
9910451 | 163578 | 0 | None | -912 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 428 | 5 | 0 | 6 | 4.7 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCC#N)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
CHEMBL420997 | 163578 | 0 | None | -912 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 428 | 5 | 0 | 6 | 4.7 | Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCC#N)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm020938y | ||
11152225 | 5058 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cc(Cl)cc(OCC2CN(Cc3ccccc3)CCO2)c1 | 10.1021/jm031111m | ||
CHEMBL105690 | 5058 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.6 | COc1cc(Cl)cc(OCC2CN(Cc3ccccc3)CCO2)c1 | 10.1021/jm031111m | ||
127046948 | 139540 | 0 | None | -398 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 488 | 12 | 4 | 6 | 4.1 | COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
CHEMBL3800468 | 139540 | 0 | None | -398 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 488 | 12 | 4 | 6 | 4.1 | COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1 | 10.1016/j.bmc.2016.04.028 | ||
44582705 | 186413 | 0 | None | -5 | 13 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 399 | 9 | 0 | 4 | 4.5 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
CHEMBL490632 | 186413 | 0 | None | -5 | 13 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 399 | 9 | 0 | 4 | 4.5 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm025558r | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm025558r | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm025558r | ||
9928553 | 17258 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 354 | 3 | 0 | 4 | 3.8 | O=c1ccc2ccc(CN3CCN(c4ccc(Cl)cc4)CC3)cc2o1 | 10.1021/jm990266k | ||
CHEMBL125763 | 17258 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 354 | 3 | 0 | 4 | 3.8 | O=c1ccc2ccc(CN3CCN(c4ccc(Cl)cc4)CC3)cc2o1 | 10.1021/jm990266k | ||
53359025 | 62024 | 0 | None | 2 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 5 | 1 | 3 | 2.5 | O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1 | 10.1016/j.bmcl.2011.04.098 | ||
CHEMBL1779058 | 62024 | 0 | None | 2 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 5 | 1 | 3 | 2.5 | O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1 | 10.1016/j.bmcl.2011.04.098 | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm040190e | ||
9980998 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm0611152 | ||
CHEMBL139926 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm0611152 | ||
CHEMBL2112911 | 30819 | 0 | None | -1148 | 8 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 5.1 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1 | 10.1021/jm0611152 | ||
10522334 | 104933 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 357 | 4 | 1 | 2 | 4.6 | c1ccc(CCN2CCC3(CCc4c3n[nH]c4-c3ccccc3)CC2)cc1 | 10.1021/jm970111h | ||
CHEMBL311832 | 104933 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 357 | 4 | 1 | 2 | 4.6 | c1ccc(CCN2CCC3(CCc4c3n[nH]c4-c3ccccc3)CC2)cc1 | 10.1021/jm970111h | ||
44323870 | 111102 | 0 | None | -9 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 364 | 1 | 0 | 2 | 5.2 | CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
CHEMBL328246 | 111102 | 0 | None | -9 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 364 | 1 | 0 | 2 | 5.2 | CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21 | 10.1021/jm00043a008 | ||
44393737 | 65430 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 646 | 4 | 1 | 4 | 5.7 | Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)c1Br | 10.1016/j.bmcl.2004.07.068 | ||
CHEMBL183466 | 65430 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 646 | 4 | 1 | 4 | 5.7 | Cc1c(Br)cc(Br)c(NC(=O)CN2CCN(c3ccc(Br)cc3C#N)CC2)c1Br | 10.1016/j.bmcl.2004.07.068 | ||
49798799 | 14243 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 3.8 | CSc1ccc(C2(O)CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1172209 | 14243 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 3.8 | CSc1ccc(C2(O)CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200150 | 14243 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 353 | 4 | 2 | 4 | 3.8 | CSc1ccc(C2(O)CCN(Cc3c[nH]c4ncccc34)CC2)cc1 | 10.1016/j.bmc.2010.05.052 | ||
20256387 | 4704 | 1 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 227 | 6 | 1 | 2 | 2.9 | c1ccc(CNCCOc2ccccc2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
CHEMBL103951 | 4704 | 1 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 227 | 6 | 1 | 2 | 2.9 | c1ccc(CNCCOc2ccccc2)cc1 | 10.1016/s0960-894x(98)00014-6 | ||
122181326 | 121353 | 0 | None | -30 | 6 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 413 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
CHEMBL3590077 | 121353 | 0 | None | -30 | 6 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 413 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1021/acs.jmedchem.9b01085 | ||
137636498 | 155655 | 0 | None | -40 | 6 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 3.8 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
CHEMBL4064186 | 155655 | 0 | None | -40 | 6 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 3.8 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | ||
122181326 | 121353 | 0 | None | -30 | 6 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 413 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2014.12.012 | ||
CHEMBL3590077 | 121353 | 0 | None | -30 | 6 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 413 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2014.12.012 | ||
749986 | 202560 | 10 | None | 15 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 289 | 3 | 1 | 2 | 3.9 | C1=C(c2nc3ccccc3[nH]2)CCN(Cc2ccccc2)C1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL71173 | 202560 | 10 | None | 15 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 289 | 3 | 1 | 2 | 3.9 | C1=C(c2nc3ccccc3[nH]2)CCN(Cc2ccccc2)C1 | 10.1016/S0960-894X(97)00402-2 | ||
49798835 | 14246 | 0 | None | -14 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.7 | OC1(c2ccc(Br)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1172213 | 14246 | 0 | None | -14 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.7 | OC1(c2ccc(Br)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200153 | 14246 | 0 | None | -14 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.7 | OC1(c2ccc(Br)cc2)CCN(Cc2coc3ccccc23)CC1 | 10.1016/j.bmc.2010.05.052 | ||
15508240 | 110038 | 0 | None | 6 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 264 | 3 | 0 | 2 | 3.3 | C#Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL325104 | 110038 | 0 | None | 6 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 264 | 3 | 0 | 2 | 3.3 | C#Cc1cccn1C1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(99)00540-5 | ||
49798857 | 14200 | 0 | None | -117 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 4.0 | O=C1N(CCF)CN(c2ccccc2)C12CCN(Cc1coc3ccccc13)CC2 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1170085 | 14200 | 0 | None | -117 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 4.0 | O=C1N(CCF)CN(c2ccccc2)C12CCN(Cc1coc3ccccc13)CC2 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1199947 | 14200 | 0 | None | -117 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 4.0 | O=C1N(CCF)CN(c2ccccc2)C12CCN(Cc1coc3ccccc13)CC2 | 10.1016/j.bmc.2010.05.052 | ||
154725276 | 175716 | 1 | None | -34 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 478 | 12 | 1 | 3 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4456964 | 175716 | 1 | None | -34 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 478 | 12 | 1 | 3 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595147 | 175716 | 1 | None | -34 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 478 | 12 | 1 | 3 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | ||
23290944 | 81414 | 0 | None | -323 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 392 | 6 | 0 | 4 | 3.8 | O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
CHEMBL2164350 | 81414 | 0 | None | -323 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 392 | 6 | 0 | 4 | 3.8 | O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1 | 10.1016/j.bmcl.2012.05.119 | ||
44336055 | 5278 | 0 | None | 43 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CC1CCc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106897 | 5278 | 0 | None | 43 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 397 | 4 | 0 | 3 | 3.8 | CC1CCc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(02)00655-8 | ||
145993990 | 166800 | 0 | None | -21 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 372 | 7 | 2 | 4 | 3.1 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(F)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
CHEMBL4294577 | 166800 | 0 | None | -21 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 372 | 7 | 2 | 4 | 3.1 | COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(F)cc1)CC2 | 10.1021/acsmedchemlett.8b00229 | ||
155563301 | 174678 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
CHEMBL4572245 | 174678 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 344 | 4 | 1 | 4 | 2.8 | Cc1cccc(NC(=O)CN2CCN(c3ccc(Cl)cn3)CC2)c1 | 10.1021/acs.jmedchem.9b00231 | ||
168284020 | 190659 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.6 | Cc1nc(CN2CCC(OCc3ccc(Cl)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
CHEMBL5190239 | 190659 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 387 | 5 | 0 | 4 | 4.6 | Cc1nc(CN2CCC(OCc3ccc(Cl)c(F)c3)CC2)c2ccccn12 | 10.1016/j.bmcl.2022.128615 | ||
137651576 | 156946 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 308 | 7 | 0 | 3 | 3.6 | COc1cccc(CCC2=NCCN2CCc2ccccc2)c1 | 10.1021/acs.jmedchem.8b00265 | ||
CHEMBL4079495 | 156946 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 308 | 7 | 0 | 3 | 3.6 | COc1cccc(CCC2=NCCN2CCc2ccccc2)c1 | 10.1021/acs.jmedchem.8b00265 | ||
164612933 | 184417 | 0 | None | -9 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 436 | 6 | 2 | 4 | 4.5 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1cccc(Cl)c1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4854512 | 184417 | 0 | None | -9 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 436 | 6 | 2 | 4 | 4.5 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1cccc(Cl)c1)CC2 | 10.1016/j.bmcl.2021.128047 | ||
164627090 | 185976 | 0 | None | -12 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.9 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccccc1OC)CC2 | 10.1016/j.bmcl.2021.128047 | ||
CHEMBL4878121 | 185976 | 0 | None | -12 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.9 | COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccccc1OC)CC2 | 10.1016/j.bmcl.2021.128047 | ||
9843032 | 108046 | 0 | None | 45 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.6 | CC1CN(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL320067 | 108046 | 0 | None | 45 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 383 | 4 | 0 | 3 | 3.6 | CC1CN(C(=O)CN2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00655-8 | ||
44431468 | 87842 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2ccc(C(F)(F)F)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
CHEMBL234824 | 87842 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 5.3 | O=C(NC1CCN(Cc2ccc(C(F)(F)F)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2006.12.106 | ||
10110263 | 12883 | 1 | None | -7 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 7 | 0 | 4 | 4.6 | Fc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL1189648 | 12883 | 1 | None | -7 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 7 | 0 | 4 | 4.6 | Fc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
CHEMBL539235 | 12883 | 1 | None | -7 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 379 | 7 | 0 | 4 | 4.6 | Fc1ccc(-c2cc(CCCCN3CCN(c4ccccc4)CC3)on2)cc1 | 10.1016/s0960-894x(02)00179-8 | ||
15508242 | 164697 | 0 | None | 32 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 268 | 4 | 0 | 3 | 3.1 | O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(99)00540-5 | ||
CHEMBL422959 | 164697 | 0 | None | 32 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 268 | 4 | 0 | 3 | 3.1 | O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1 | 10.1016/s0960-894x(99)00540-5 | ||
45270813 | 195014 | 0 | None | -112 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 365 | 4 | 0 | 6 | 3.0 | COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1 | 10.1016/j.bmc.2009.05.015 | ||
CHEMBL564709 | 195014 | 0 | None | -112 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 365 | 4 | 0 | 6 | 3.0 | COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1 | 10.1016/j.bmc.2009.05.015 | ||
154704418 | 176013 | 1 | None | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 12 | 1 | 6 | 4.8 | Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4546749 | 176013 | 1 | None | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 12 | 1 | 6 | 4.8 | Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4597533 | 176013 | 1 | None | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 12 | 1 | 6 | 4.8 | Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 | 10.1021/acs.jmedchem.9b01835 | ||
12581203 | 24869 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 233 | 4 | 0 | 2 | 2.9 | CCN(CC)C1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
CHEMBL134701 | 24869 | 0 | None | -7 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 233 | 4 | 0 | 2 | 2.9 | CCN(CC)C1CCc2c(cccc2OC)C1 | 10.1021/jm960345l | ||
25141538 | 55948 | 0 | None | -407 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 440 | 8 | 3 | 5 | 2.6 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1 | 10.1021/jm900095y | ||
CHEMBL1627311 | 55948 | 0 | None | -407 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 440 | 8 | 3 | 5 | 2.6 | COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1 | 10.1021/jm900095y | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm991098z | ||
44330694 | 107102 | 0 | None | 9 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 260 | 2 | 0 | 3 | 4.1 | CCCn1ncc2c1-c1c(C)sc(C)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
CHEMBL318949 | 107102 | 0 | None | 9 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 260 | 2 | 0 | 3 | 4.1 | CCCn1ncc2c1-c1c(C)sc(C)c1CCC2 | 10.1016/s0960-894x(03)00587-0 | ||
44403224 | 71571 | 0 | None | -10 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 4 | 3.9 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1 | 10.1016/j.bmcl.2005.07.037 | ||
CHEMBL197195 | 71571 | 0 | None | -10 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 4 | 3.9 | O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1 | 10.1016/j.bmcl.2005.07.037 | ||
22100968 | 202405 | 4 | None | 2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 290 | 3 | 0 | 3 | 4.1 | C1=C(c2nc3ccccc3o2)CCN(Cc2ccccc2)C1 | 10.1016/S0960-894X(97)00402-2 | ||
CHEMBL70267 | 202405 | 4 | None | 2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 290 | 3 | 0 | 3 | 4.1 | C1=C(c2nc3ccccc3o2)CCN(Cc2ccccc2)C1 | 10.1016/S0960-894X(97)00402-2 | ||
11230330 | 134664 | 0 | None | -19 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 245 | 5 | 0 | 3 | 2.8 | CCCN(CCC)[C@H]1CCn2c(C#N)ccc2C1 | 10.1021/jm049269+ | ||
CHEMBL372020 | 134664 | 0 | None | -19 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 245 | 5 | 0 | 3 | 2.8 | CCCN(CCC)[C@H]1CCn2c(C#N)ccc2C1 | 10.1021/jm049269+ | ||
44415593 | 79837 | 0 | None | -977 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 495 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
CHEMBL213834 | 79837 | 0 | None | -977 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 495 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | ||
154725234 | 175718 | 1 | None | -1 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 472 | 12 | 0 | 6 | 5.2 | CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4585289 | 175718 | 1 | None | -1 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 472 | 12 | 0 | 6 | 5.2 | CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4595149 | 175718 | 1 | None | -1 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 472 | 12 | 0 | 6 | 5.2 | CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | ||
11547151 | 83947 | 0 | None | -14 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 10 | 1 | 7 | 3.0 | COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1 | 10.1021/jm0611152 | ||
CHEMBL221843 | 83947 | 0 | None | -14 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 10 | 1 | 7 | 3.0 | COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1 | 10.1021/jm0611152 | ||
44275807 | 98513 | 0 | None | -8912 | 10 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 4.5 | C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1 | 10.1016/s0960-894x(03)00118-5 | ||
CHEMBL27979 | 98513 | 0 | None | -8912 | 10 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 4.5 | C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1 | 10.1016/s0960-894x(03)00118-5 | ||
155515301 | 169400 | 0 | None | -812 | 7 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 4.2 | COc1ccccc1N1CCN(C[C@H]2OCCOC2(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.ejmech.2019.02.056 | ||
CHEMBL4441888 | 169400 | 0 | None | -812 | 7 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 4.2 | COc1ccccc1N1CCN(C[C@H]2OCCOC2(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.ejmech.2019.02.056 | ||
49798874 | 14236 | 0 | None | -1096 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 488 | 7 | 0 | 7 | 3.8 | O=C1N(Cc2cn(CCF)nn2)CN(c2ccccc2)C12CCN(Cc1coc3ccccc13)CC2 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1171630 | 14236 | 0 | None | -1096 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 488 | 7 | 0 | 7 | 3.8 | O=C1N(Cc2cn(CCF)nn2)CN(c2ccccc2)C12CCN(Cc1coc3ccccc13)CC2 | 10.1016/j.bmc.2010.05.052 | ||
CHEMBL1200106 | 14236 | 0 | None | -1096 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 488 | 7 | 0 | 7 | 3.8 | O=C1N(Cc2cn(CCF)nn2)CN(c2ccccc2)C12CCN(Cc1coc3ccccc13)CC2 | 10.1016/j.bmc.2010.05.052 | ||
122189391 | 122730 | 0 | None | -11 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 431 | 7 | 0 | 9 | 2.1 | COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1 | 10.1016/j.bmc.2015.07.050 | ||
CHEMBL3613877 | 122730 | 0 | None | -11 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 431 | 7 | 0 | 9 | 2.1 | COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1 | 10.1016/j.bmc.2015.07.050 | ||
16090814 | 81169 | 0 | None | -74 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | ||
CHEMBL216258 | 81169 | 0 | None | -74 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | ||
142590731 | 182500 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 470 | 9 | 1 | 3 | 6.2 | Fc1ccc(CN2CCC(NCCSC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.ejmech.2020.112674 | ||
CHEMBL4794406 | 182500 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 470 | 9 | 1 | 3 | 6.2 | Fc1ccc(CN2CCC(NCCSC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.ejmech.2020.112674 | ||
154704536 | 175873 | 1 | None | -1 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4467528 | 175873 | 1 | None | -1 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
CHEMBL4596340 | 175873 | 1 | None | -1 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | ||
11637457 | 72740 | 1 | None | -8 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1039/C5MD00258C | ||
CHEMBL201093 | 72740 | 1 | None | -8 | 5 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1039/C5MD00258C | ||
51353678 | 59871 | 0 | None | -1905 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 461 | 13 | 1 | 5 | 3.7 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1ccc(OCCF)cc1 | 10.1021/jm101323b | ||
CHEMBL1689004 | 59871 | 0 | None | -1905 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 461 | 13 | 1 | 5 | 3.7 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1ccc(OCCF)cc1 | 10.1021/jm101323b | ||
CHEMBL1739810 | 59871 | 0 | None | -1905 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 461 | 13 | 1 | 5 | 3.7 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1ccc(OCCF)cc1 | 10.1021/jm101323b | ||
44380921 | 58021 | 0 | None | -2 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
CHEMBL168274 | 58021 | 0 | None | -2 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 429 | 9 | 2 | 4 | 4.7 | CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC | 10.1016/s0960-894x(99)00086-4 | ||
11212939 | 68818 | 0 | None | -10 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | ||
CHEMBL192439 | 68818 | 0 | None | -10 | 3 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | ||
44336035 | 5222 | 0 | None | 2 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 403 | 4 | 0 | 3 | 3.7 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2c(Cl)cccc21 | 10.1016/s0960-894x(02)00655-8 | ||
CHEMBL106598 | 5222 | 0 | None | 2 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 403 | 4 | 0 | 3 | 3.7 | O=C(CN1CCN(Cc2ccc(Cl)cc2)CC1)N1CCc2c(Cl)cccc21 | 10.1016/s0960-894x(02)00655-8 | ||
135 | 2496 | 38 | None | - | 57 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
1796 | 2496 | 38 | None | - | 57 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
4184 | 2496 | 38 | None | - | 57 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
CHEMBL6437 | 2496 | 38 | None | - | 57 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
DB06148 | 2496 | 38 | None | - | 57 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
9952220 | 97804 | 5 | None | -8 | 4 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)[C@H]2C)cc1Cl | None | ||
CHEMBL274491 | 97804 | 5 | None | -8 | 4 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 387 | 6 | 2 | 4 | 3.8 | CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)[C@H]2C)cc1Cl | None | ||
188942 | 2778 | 38 | None | -12 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 9262371 | ||
3297 | 2778 | 38 | None | -12 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 9262371 | ||
979 | 2778 | 38 | None | -12 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 9262371 | ||
CHEMBL103772 | 2778 | 38 | None | -12 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 9262371 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1840645 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7777184 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1840645 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7777184 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1840645 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7777184 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1840645 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7777184 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1840645 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7777184 | ||
4452 | 2721 | 18 | None | -7 | 18 | Human | 10.0 | pKd | None | 10 | Binding | Guide to Pharmacology | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 8248849 | ||
983 | 2721 | 18 | None | -7 | 18 | Human | 10.0 | pKd | None | 10 | Binding | Guide to Pharmacology | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 8248849 | ||
CHEMBL20734 | 2721 | 18 | None | -7 | 18 | Human | 10.0 | pKd | None | 10 | Binding | Guide to Pharmacology | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | 8248849 | ||
4452 | 2721 | 18 | 3H-YM 09151-2 | -7 | 18 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | None | ||
983 | 2721 | 18 | 3H-YM 09151-2 | -7 | 18 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | None | ||
CHEMBL20734 | 2721 | 18 | 3H-YM 09151-2 | -7 | 18 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 387 | 6 | 2 | 4 | 3.8 | COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl | None | ||
2470 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
16363 | 589 | 48 | UNDEFINED | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
312 | 589 | 48 | UNDEFINED | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
9215 | 589 | 48 | UNDEFINED | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
CHEMBL297302 | 589 | 48 | UNDEFINED | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
DB12867 | 589 | 48 | UNDEFINED | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
2470 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
2470 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
None | 214526 | 0 | UNDEFINED | 4 | 11 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 426 | 6 | 0 | 6 | 3.4 | C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54 | None | ||
2 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
54562 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
CHEMBL240773 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
2389 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
2389 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
5567 | 42556 | 24 | UNDEFINED | -11 | 7 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 409 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL15023 | 42556 | 24 | UNDEFINED | -11 | 7 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 409 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 | None | ||
2470 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | 3H-SPIPERONE | -4 | 59 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
1238 | 201484 | 21 | R-SAT | -2 | 16 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
CHEMBL64249 | 201484 | 21 | R-SAT | -2 | 16 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
3303 | 2213 | 41 | UNDEFINED | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | None | ||
5311200 | 2213 | 41 | UNDEFINED | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | None | ||
CHEMBL267014 | 2213 | 41 | UNDEFINED | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | None | ||
11976 | 907 | 54 | UNDEFINED | -2 | 23 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
667467 | 907 | 54 | UNDEFINED | -2 | 23 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
CHEMBL908 | 907 | 54 | UNDEFINED | -2 | 23 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
DB01239 | 907 | 54 | UNDEFINED | -2 | 23 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
1353 | 1880 | 85 | 3H-SPIROPERIDOL | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIROPERIDOL | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIROPERIDOL | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIROPERIDOL | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIROPERIDOL | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
2865 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
59 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
60854 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL708 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
DB00246 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
1353 | 1880 | 85 | 3H-Haloperidol | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
1353 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-Haloperidol | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-Haloperidol | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-Haloperidol | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-Haloperidol | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3168 | 9172 | 84 | UNDEFINED | -4 | 21 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
CHEMBL1108 | 9172 | 84 | UNDEFINED | -4 | 21 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
2435 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
2435 | 3533 | 78 | UNDEFINED | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | UNDEFINED | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | UNDEFINED | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | UNDEFINED | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | UNDEFINED | -10 | 48 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
2435 | 3533 | 78 | 3H-Sertindole | -10 | 48 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | 3H-Sertindole | -10 | 48 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | 3H-Sertindole | -10 | 48 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | 3H-Sertindole | -10 | 48 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | 3H-Sertindole | -10 | 48 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
2726 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2726 | 906 | 64 | 3H-Chlorpromazine | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2726 | 906 | 64 | UNDEFINED | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-Chlorpromazine | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | UNDEFINED | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-Chlorpromazine | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | UNDEFINED | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-Chlorpromazine | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | UNDEFINED | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-Chlorpromazine | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | UNDEFINED | -8 | 72 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2470 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
100 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
100 | 3745 | 52 | UNDEFINED | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | UNDEFINED | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | UNDEFINED | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | UNDEFINED | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | UNDEFINED | -8 | 55 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
135398737 | 944 | 89 | 3H-Clozapine | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
135398737 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-Clozapine | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-Clozapine | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-Clozapine | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-Clozapine | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
5281878 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5281881 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
948 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
968 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL42055 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL54661 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00875 | 1630 | 33 | UNDEFINED | -14 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
135398745 | 2869 | 108 | 3H-Olanzapine | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
135398745 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-Olanzapine | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-Olanzapine | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-Olanzapine | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
3303 | 2213 | 41 | R-SAT | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | None | ||
5311200 | 2213 | 41 | R-SAT | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | None | ||
CHEMBL267014 | 2213 | 41 | R-SAT | 1 | 15 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | None | ||
16362 | 3076 | 67 | R-SAT | -20 | 29 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
2172 | 3076 | 67 | R-SAT | -20 | 29 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
90 | 3076 | 67 | R-SAT | -20 | 29 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
CHEMBL1423 | 3076 | 67 | R-SAT | -20 | 29 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
DB01100 | 3076 | 67 | R-SAT | -20 | 29 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
46780481 | 107045 | 18 | 3H-NMSP | -23 | 53 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
9903970 | 107045 | 18 | 3H-NMSP | -23 | 53 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
CHEMBL3187365 | 107045 | 18 | 3H-NMSP | -23 | 53 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
CHEMBL3544974 | 107045 | 18 | 3H-NMSP | -23 | 53 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
1613 | 2316 | 44 | 3H-NEMONAPRIDE | -2 | 44 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-NEMONAPRIDE | -2 | 44 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-NEMONAPRIDE | -2 | 44 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-NEMONAPRIDE | -2 | 44 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-NEMONAPRIDE | -2 | 44 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
100 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
115368 | 3007 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | None | ||
2112 | 3007 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | None | ||
7556 | 3007 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | None | ||
CHEMBL1472975 | 3007 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | None | ||
DB08922 | 3007 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | None | ||
2435 | 3533 | 78 | 3H-SPIPERONE | -19 | 48 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | 3H-SPIPERONE | -19 | 48 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | 3H-SPIPERONE | -19 | 48 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | 3H-SPIPERONE | -19 | 48 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | 3H-SPIPERONE | -19 | 48 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
100 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-SPIPERONE | -8 | 55 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
4257 | 77868 | 26 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 478 | 4 | 1 | 4 | 4.7 | O=C1NC2CCCCN2C12CCN(CCCN1c3ccccc3CCc3ccc(Cl)cc31)CC2 | None | ||
CHEMBL2106650 | 77868 | 26 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 478 | 4 | 1 | 4 | 4.7 | O=C1NC2CCCCN2C12CCN(CCCN1c3ccccc3CCc3ccc(Cl)cc31)CC2 | None | ||
25139335 | 183736 | 0 | UNDEFINED | 2 | 3 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 314 | 8 | 0 | 4 | 3.6 | CC#CC1=CCC(N(CCC)CCCCn2cc(C)nn2)CC1 | None | ||
CHEMBL484203 | 183736 | 0 | UNDEFINED | 2 | 3 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 314 | 8 | 0 | 4 | 3.6 | CC#CC1=CCC(N(CCC)CCCCn2cc(C)nn2)CC1 | None | ||
242 | 467 | 117 | R-SAT | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
34 | 467 | 117 | R-SAT | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
60795 | 467 | 117 | R-SAT | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL1112 | 467 | 117 | R-SAT | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB01238 | 467 | 117 | R-SAT | -117 | 51 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
5281878 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5281881 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
948 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
968 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL42055 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL54661 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00875 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2865 | 4079 | 67 | R-SAT | -66 | 53 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
59 | 4079 | 67 | R-SAT | -66 | 53 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
60854 | 4079 | 67 | R-SAT | -66 | 53 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL708 | 4079 | 67 | R-SAT | -66 | 53 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
DB00246 | 4079 | 67 | R-SAT | -66 | 53 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
54477 | 84230 | 34 | R-SAT | -14 | 22 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | R-SAT | -14 | 22 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
15387 | 214209 | 0 | R-SAT | -35 | 23 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
119192 | 2446 | 48 | 3H-N-Methylspiporone | -2818 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | ||
1582 | 2446 | 48 | 3H-N-Methylspiporone | -2818 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | ||
CHEMBL506981 | 2446 | 48 | 3H-N-Methylspiporone | -2818 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | ||
DB06455 | 2446 | 48 | 3H-N-Methylspiporone | -2818 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | ||
134 | 2478 | 19 | 3H-NMSP | -8511 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
1775 | 2478 | 19 | 3H-NMSP | -8511 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
9681 | 2478 | 19 | 3H-NMSP | -8511 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
CHEMBL1065 | 2478 | 19 | 3H-NMSP | -8511 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
DB00247 | 2478 | 19 | 3H-NMSP | -8511 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
15897 | 2817 | 0 | 3H-NMSP | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | ||
215 | 2817 | 0 | 3H-NMSP | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | ||
CHEMBL1979333 | 2817 | 0 | 3H-NMSP | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | ||
128563 | 3408 | 28 | 3H-NMSP | -2398 | 40 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
1666 | 3408 | 28 | 3H-NMSP | -2398 | 40 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
CHEMBL445332 | 3408 | 28 | 3H-NMSP | -2398 | 40 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
DB12327 | 3408 | 28 | 3H-NMSP | -2398 | 40 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
189 | 3436 | 31 | 3H-YM 09151-1 | -4168 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | ||
5163 | 3436 | 31 | 3H-YM 09151-1 | -4168 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | ||
CHEMBL297784 | 3436 | 31 | 3H-YM 09151-1 | -4168 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
185 | 3943 | 54 | 3H-NMSP | -7244 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
5311271 | 3943 | 54 | 3H-NMSP | -7244 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
CHEMBL74355 | 3943 | 54 | 3H-NMSP | -7244 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
DB16351 | 3943 | 54 | 3H-NMSP | -7244 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
2662 | 11279 | 124 | 3H-NMSP | -41 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | ||
CHEMBL118 | 11279 | 124 | 3H-NMSP | -41 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | ||
10297 | 26905 | 29 | 3H-NMSP | -38 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | ||
CHEMBL136560 | 26905 | 29 | 3H-NMSP | -38 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | ||
156391 | 46537 | 95 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | ||
CHEMBL1200806 | 46537 | 95 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | ||
CHEMBL154 | 46537 | 95 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | ||
10624 | 69957 | 17 | 3H-NMSP | -102 | 32 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
138543650 | 69957 | 17 | 3H-NMSP | -102 | 32 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
CHEMBL194378 | 69957 | 17 | 3H-NMSP | -102 | 32 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
2244 | 93798 | 96 | 3H-NMSP | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | ||
CHEMBL25 | 93798 | 96 | 3H-NMSP | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | ||
24840389 | 114714 | 3 | 3H-SPIPERONE | -7413 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 415 | 9 | 0 | 4 | 4.6 | CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 | None | ||
CHEMBL334529 | 114714 | 3 | 3H-SPIPERONE | -7413 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 415 | 9 | 0 | 4 | 4.6 | CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 | None | ||
446220 | 132998 | 13 | 3H-NMSP | -1778 | 45 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | ||
CHEMBL370805 | 132998 | 13 | 3H-NMSP | -1778 | 45 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | ||
1615 | 167228 | 22 | 3H-NMSP | -26 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | ||
1615 | 167228 | 22 | 3H-NMSP | -26 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | ||
CHEMBL43048 | 167228 | 22 | 3H-NMSP | -26 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | ||
CHEMBL43048 | 167228 | 22 | 3H-NMSP | -26 | 44 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | ||
54676228 | 192874 | 108 | 3H-NMSP | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | ||
CHEMBL527 | 192874 | 108 | 3H-NMSP | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | ||
4495 | 194860 | 87 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | ||
CHEMBL56367 | 194860 | 87 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | ||
54677470 | 198867 | 110 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | ||
CHEMBL1256873 | 198867 | 110 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | ||
CHEMBL599 | 198867 | 110 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | ||
162265 | 200587 | 19 | 3H-NMSP | -239 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | ||
4786 | 200587 | 19 | 3H-NMSP | -239 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | ||
CHEMBL61006 | 200587 | 19 | 3H-NMSP | -239 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | ||
5281600 | 201336 | 85 | 3H-Methylspiperone | -275 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL63354 | 201336 | 85 | 3H-Methylspiperone | -275 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | ||
4054 | 203790 | 64 | 3H-NMSP | -1 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | ||
CHEMBL1699 | 203790 | 64 | 3H-NMSP | -1 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | ||
CHEMBL807 | 203790 | 64 | 3H-NMSP | -1 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | ||
11954224 | 214174 | 0 | 3H-NMSP | -141253 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | ||
None | 214217 | 0 | 3H-N-Methylspiperone | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 2 | 0 | 4 | 3.6 | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl | None | ||
25137849 | 214425 | 0 | 3H-NMSP | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | ||
71290 | 214425 | 0 | 3H-NMSP | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | ||
3337 | 214441 | 0 | 3H-NMSP | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
65801 | 214441 | 0 | 3H-NMSP | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
66264 | 214441 | 0 | 3H-NMSP | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
91452 | 214441 | 0 | 3H-NMSP | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
None | 214486 | 0 | 3H-NMSP | -95499 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 316 | 7 | 3 | 3 | 3.0 | CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O | None | ||
3821 | 214549 | 0 | 3H-N-Methylspiperone | -1 | 18 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(CCCCC1=O)C2=CC=CC=C2Cl | None | ||
None | 214560 | 0 | 3H-NMSP | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 240 | 7 | 4 | 6 | -0.8 | C(C(C(=O)O)N)SSCC(C(=O)O)N | None | ||
None | 214561 | 0 | 3H-NMSP | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 4 | 2 | 3 | 0.2 | CSCCC(C(=O)O)N | None | ||
None | 214562 | 0 | 3H-NMSP | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 135 | 3 | 3 | 3 | -0.3 | C(CS)C(C(=O)O)N | None | ||
None | 214563 | 0 | 3H-NMSP | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 3 | 3 | -0.7 | C(C(C(=O)O)N)S | None | ||
None | 214564 | 0 | 3H-NMSP | -1 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 117 | 0 | 1 | 3 | -0.0 | C1CSC(=O)C1N | None | ||
None | 214565 | 0 | 3H-NMSP | -1 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 3 | 3 | 3 | -1.4 | C(C(C(=O)O)N)S(=O)O | None | ||
None | 214566 | 0 | 3H-NMSP | -1 | 38 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 3 | 3 | 4 | -1.7 | C(C(C(=O)O)N)S(=O)(=O)O | None | ||
None | 214567 | 0 | 3H-NMSP | -1 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 183 | 4 | 3 | 4 | -1.3 | C(CS(=O)(=O)O)C(C(=O)O)N | None | ||
None | 214574 | 0 | 3H-NMSP | -13 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.2 | CC(C(=O)C1=CC=CC=C1)N | None | ||
1576 | 214575 | 0 | 3H-NMSP | -16 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 163 | 3 | 1 | 2 | 1.5 | CC(C(=O)C1=CC=CC=C1)NC | None | ||
None | 214576 | 0 | 3H-Methylspiperone | -16 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 536 | 11 | 1 | 4 | 9.0 | CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C | None | ||
None | 214578 | 0 | 3H-Methylspiperone | -3 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 464 | 4 | 8 | 12 | -0.6 | C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O | None | ||
None | 214579 | 0 | 3H-Methylspiperone | -281 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 610 | 6 | 10 | 16 | -1.7 | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O | None | ||
None | 214580 | 0 | 3H-Methylspiperone | -1 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 448 | 3 | 7 | 11 | 0.4 | CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O | None | ||
135269 | 214639 | 0 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 222 | 5 | 1 | 3 | 2.5 | CCCCC(=O)OC1=CC=CC=C1C(=O)O | None | ||
23681059 | 214640 | 0 | 3H-NMSP | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O | None | ||
5018304 | 214641 | 0 | 3H-NMSP | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 317 | 4 | 1 | 3 | 0.0 | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] | None | ||
3672 | 214642 | 0 | 3H-NMSP | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)CC1=CC=C(C=C1)C(C)C(=O)O | None | ||
84003 | 214643 | 0 | 3H-NMSP | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 376 | 6 | 5 | 7 | -0.0 | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O | None | ||
119828 | 214645 | 0 | 3H-NMSP | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 5 | 1 | 5 | 3.5 | CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C | None | ||
None | 214703 | 0 | 3H-SPIPERONE | -660 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | ||
None | 214703 | 0 | UNDEFINED | -660 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | ||
None | 214747 | 0 | 3H-NMSP | -4570 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 347 | 6 | 0 | 3 | 5.0 | CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
135409468 | 2004 | 63 | 3H-NMSP | -18 | 40 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
333 | 2004 | 63 | 3H-NMSP | -18 | 40 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
CHEMBL845 | 2004 | 63 | 3H-NMSP | -18 | 40 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
44395711 | 174327 | 0 | UNDEFINED | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | None | ||
CHEMBL456430 | 174327 | 0 | UNDEFINED | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | None | ||
CHEMBL537183 | 174327 | 0 | UNDEFINED | -5 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 345 | 3 | 1 | 2 | 4.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1ccc(F)cc1 | None | ||
1353 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
2865 | 4079 | 67 | 3H-NMSP | -66 | 53 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
59 | 4079 | 67 | 3H-NMSP | -66 | 53 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
60854 | 4079 | 67 | 3H-NMSP | -66 | 53 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL708 | 4079 | 67 | 3H-NMSP | -66 | 53 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
DB00246 | 4079 | 67 | 3H-NMSP | -66 | 53 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
2337 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
9906978 | 42466 | 1 | UNDEFINED | 1 | 12 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
CHEMBL150161 | 42466 | 1 | UNDEFINED | 1 | 12 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
25139329 | 186520 | 0 | UNDEFINED | -7 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 514 | 10 | 0 | 4 | 7.6 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1 | None | ||
CHEMBL491466 | 186520 | 0 | UNDEFINED | -7 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 514 | 10 | 0 | 4 | 7.6 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1 | None | ||
2274 | 3124 | 53 | R-SAT | -56 | 32 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4917 | 3124 | 53 | R-SAT | -56 | 32 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
7279 | 3124 | 53 | R-SAT | -56 | 32 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL728 | 3124 | 53 | R-SAT | -56 | 32 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00433 | 3124 | 53 | R-SAT | -56 | 32 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2337 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
37459 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
62 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
CHEMBL8514 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
1613 | 2316 | 44 | 3H-NMSP | -2 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
1613 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-NMSP | -2 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-NMSP | -2 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-NMSP | -2 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-NMSP | -2 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
100 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2726 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
1353 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
None | 214476 | 0 | 3H-YM 09151-2 | 15 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 291 | 3 | 2 | 2 | 3.8 | C1=CC=C2C(=C1)C=CC=C2NC(=O)C3=CC=CC=C3C(=O)O | None | ||
2337 | 3205 | 72 | 3H-NMSP | -114 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-NMSP | -114 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-NMSP | -114 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-NMSP | -114 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-NMSP | -114 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
44591089 | 188892 | 0 | UNDEFINED | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 3 | 2 | 3 | 3.3 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ncccc23)C1 | None | ||
CHEMBL513776 | 188892 | 0 | UNDEFINED | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 3 | 2 | 3 | 3.3 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ncccc23)C1 | None | ||
2 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
54562 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
CHEMBL240773 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
4978 | 214577 | 0 | 3H-Methylspiperone | -2 | 28 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 520 | 1 | 7 | 9 | 4.3 | CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O | None | ||
119570 | 3110 | 90 | 3H-SPIPERONE | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
2233 | 3110 | 90 | 3H-SPIPERONE | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
953 | 3110 | 90 | 3H-SPIPERONE | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
CHEMBL301265 | 3110 | 90 | 3H-SPIPERONE | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
DB00413 | 3110 | 90 | 3H-SPIPERONE | -10 | 40 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
6603820 | 95330 | 13 | 3H-SCH23390 | -1 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | None | ||
CHEMBL25856 | 95330 | 13 | 3H-SCH23390 | -1 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | None | ||
None | 214476 | 0 | 3H-SPIPERONE | 15 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 291 | 3 | 2 | 2 | 3.8 | C1=CC=C2C(=C1)C=CC=C2NC(=O)C3=CC=CC=C3C(=O)O | None | ||
1712 | 2456 | 0 | 3H-SPIPERONE | -3 | 21 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
4078 | 2456 | 0 | 3H-SPIPERONE | -3 | 21 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
7227 | 2456 | 0 | 3H-SPIPERONE | -3 | 21 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
CHEMBL1088 | 2456 | 0 | 3H-SPIPERONE | -3 | 21 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
DB00933 | 2456 | 0 | 3H-SPIPERONE | -3 | 21 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
101 | 3762 | 18 | 3H-SPIPERONE | -21 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 440 | 6 | 0 | 6 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
55752 | 3762 | 18 | 3H-SPIPERONE | -21 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 440 | 6 | 0 | 6 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL35057 | 3762 | 18 | 3H-SPIPERONE | -21 | 13 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 440 | 6 | 0 | 6 | 3.9 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
279 | 1631 | 26 | 3H-SPIPERONE | -26 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 3.1 | CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 | None | ||
49381 | 1631 | 26 | 3H-SPIPERONE | -26 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 3.1 | CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 | None | ||
CHEMBL63756 | 1631 | 26 | 3H-SPIPERONE | -26 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 3.1 | CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 | None | ||
5281878 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5281881 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
948 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
968 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL42055 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL54661 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00875 | 1630 | 33 | R-SAT | -14 | 16 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
None | 214399 | 0 | 3H-YM 09151-2 | -1 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 233 | 4 | 1 | 2 | 3.1 | CCCNC1CCC2=C(C1C)C=CC=C2OC | None | ||
3033769 | 3229 | 54 | 3H-YM 09151-2 | -562 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-YM 09151-2 | -562 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-YM 09151-2 | -562 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-YM 09151-2 | -562 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-YM 09151-2 | -562 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
15387 | 214209 | 0 | 3H-YM 09151-2 | -35 | 23 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
135398745 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
5467 | 204212 | 40 | R-SAT | 6 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 328 | 8 | 1 | 5 | 1.2 | CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC | None | ||
CHEMBL84158 | 204212 | 40 | R-SAT | 6 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 328 | 8 | 1 | 5 | 1.2 | CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC | None | ||
2274 | 3124 | 53 | 3H-NEMONAPRIDE | -56 | 32 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4917 | 3124 | 53 | 3H-NEMONAPRIDE | -56 | 32 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
7279 | 3124 | 53 | 3H-NEMONAPRIDE | -56 | 32 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL728 | 3124 | 53 | 3H-NEMONAPRIDE | -56 | 32 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00433 | 3124 | 53 | 3H-NEMONAPRIDE | -56 | 32 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
25139332 | 183737 | 0 | UNDEFINED | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 352 | 11 | 1 | 2 | 5.0 | CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1 | None | ||
CHEMBL484204 | 183737 | 0 | UNDEFINED | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 352 | 11 | 1 | 2 | 5.0 | CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1 | None | ||
None | 215619 | 0 | UNDEFINED | -380 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 451 | 3 | 0 | 7 | 3.9 | CC1=NC2=C(C=C1)C3=C(C=C2)OCC(O3)CN4CCN(CC4)C5=NC6=C(C=C5)C=C(C=C6)C#N | None | ||
3663 | 99505 | 79 | 3H-Methylspiperone | -42 | 29 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | None | ||
CHEMBL286494 | 99505 | 79 | 3H-Methylspiperone | -42 | 29 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | None | ||
1353 | 1880 | 85 | 3H-NMSP | -3 | 85 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-NMSP | -3 | 85 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-NMSP | -3 | 85 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-NMSP | -3 | 85 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-NMSP | -3 | 85 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
135398745 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
2726 | 906 | 64 | 3H-YM 09151-2 | -8 | 72 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-YM 09151-2 | -8 | 72 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-YM 09151-2 | -8 | 72 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-YM 09151-2 | -8 | 72 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-YM 09151-2 | -8 | 72 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
133633 | 2210 | 46 | UNDEFINED | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | None | ||
177 | 2210 | 46 | UNDEFINED | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | None | ||
CHEMBL445102 | 2210 | 46 | UNDEFINED | -104 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 4.3 | Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2 | None | ||
2435 | 3533 | 78 | 3H-NEMONAPRIDE | -10 | 48 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | 3H-NEMONAPRIDE | -10 | 48 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | 3H-NEMONAPRIDE | -10 | 48 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | 3H-NEMONAPRIDE | -10 | 48 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | 3H-NEMONAPRIDE | -10 | 48 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
104911 | 214249 | 0 | 3H-NMSP | -67 | 36 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | ||
2389 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
2337 | 3205 | 72 | 3H-NEMONAPRIDE | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-NEMONAPRIDE | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-NEMONAPRIDE | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-NEMONAPRIDE | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-NEMONAPRIDE | -114 | 62 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
6852400 | 214160 | 0 | R-SAT | -794 | 21 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
73759726 | 214160 | 0 | R-SAT | -794 | 21 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
209 | 3008 | 94 | UNDEFINED | -30 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2113 | 3008 | 94 | UNDEFINED | -30 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4748 | 3008 | 94 | UNDEFINED | -30 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL567 | 3008 | 94 | UNDEFINED | -30 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00850 | 3008 | 94 | UNDEFINED | -30 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
100 | 3745 | 52 | 3H-NMSP | -8 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-NMSP | -8 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-NMSP | -8 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-NMSP | -8 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-NMSP | -8 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
44395741 | 180999 | 0 | UNDEFINED | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL476935 | 180999 | 0 | UNDEFINED | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL558392 | 180999 | 0 | UNDEFINED | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
44395741 | 180999 | 0 | UNDEFINED | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL476935 | 180999 | 0 | UNDEFINED | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL558392 | 180999 | 0 | UNDEFINED | 1 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
44350664 | 117646 | 0 | UNDEFINED | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL340816 | 117646 | 0 | UNDEFINED | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL553417 | 117646 | 0 | UNDEFINED | -1 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
2389 | 3279 | 114 | 3H-NEMONAPRIDE | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
2389 | 3279 | 114 | R-SAT | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-NEMONAPRIDE | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | R-SAT | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-NEMONAPRIDE | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | R-SAT | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-NEMONAPRIDE | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | R-SAT | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-NEMONAPRIDE | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | R-SAT | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
103 | 4089 | 56 | 3H-NMSP | -17 | 53 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2875 | 4089 | 56 | 3H-NMSP | -17 | 53 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
5736 | 4089 | 56 | 3H-NMSP | -17 | 53 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL285802 | 4089 | 56 | 3H-NMSP | -17 | 53 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB09225 | 4089 | 56 | 3H-NMSP | -17 | 53 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2389 | 3279 | 114 | 3H-NMSP | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-NMSP | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-NMSP | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-NMSP | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-NMSP | -21 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
44591045 | 176163 | 0 | UNDEFINED | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 340 | 3 | 1 | 3 | 3.9 | Clc1ccc(N2CCCN(Cc3c[nH]c4ncccc34)CC2)cc1 | None | ||
CHEMBL460223 | 176163 | 0 | UNDEFINED | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 340 | 3 | 1 | 3 | 3.9 | Clc1ccc(N2CCCN(Cc3c[nH]c4ncccc34)CC2)cc1 | None | ||
25139478 | 184373 | 0 | UNDEFINED | -138 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 510 | 10 | 0 | 4 | 7.5 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1 | None | ||
CHEMBL485384 | 184373 | 0 | UNDEFINED | -138 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 510 | 10 | 0 | 4 | 7.5 | CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1 | None | ||
135398745 | 2869 | 108 | 3H-NMSP | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-NMSP | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-NMSP | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-NMSP | -10 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
214 | 3799 | 52 | 3H-SPIPERONE | -22 | 29 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | 3H-SPIPERONE | -22 | 29 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | 3H-SPIPERONE | -22 | 29 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | 3H-SPIPERONE | -22 | 29 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | 3H-SPIPERONE | -22 | 29 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | 3H-SPIPERONE | -22 | 29 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
None | 214591 | 0 | 3H-SPIPERONE | -3 | 19 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 246 | 2 | 1 | 4 | 1.6 | CCCN1CCCC2C1CC3=CN=C(N=C3C2)N | None | ||
13091273 | 181856 | 0 | UNDEFINED | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL478617 | 181856 | 0 | UNDEFINED | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL553327 | 181856 | 0 | UNDEFINED | -8 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
25139479 | 183735 | 0 | UNDEFINED | -21 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 438 | 10 | 0 | 4 | 6.2 | C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1 | None | ||
CHEMBL484202 | 183735 | 0 | UNDEFINED | -21 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 438 | 10 | 0 | 4 | 6.2 | C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1 | None | ||
191 | 399 | 92 | UNDEFINED | -8 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
201 | 399 | 92 | UNDEFINED | -8 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
2170 | 399 | 92 | UNDEFINED | -8 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
CHEMBL1113 | 399 | 92 | UNDEFINED | -8 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
DB00543 | 399 | 92 | UNDEFINED | -8 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
135398745 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
4249 | 77814 | 30 | UNDEFINED | -7 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 355 | 6 | 1 | 3 | 4.1 | Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | None | ||
CHEMBL2104700 | 77814 | 30 | UNDEFINED | -7 | 5 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 355 | 6 | 1 | 3 | 4.1 | Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3294 | 1975 | 106 | UNDEFINED | -11 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
71360 | 1975 | 106 | UNDEFINED | -11 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
87 | 1975 | 106 | UNDEFINED | -11 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
CHEMBL14376 | 1975 | 106 | UNDEFINED | -11 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
DB04946 | 1975 | 106 | UNDEFINED | -11 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
1353 | 1880 | 85 | 3H-NEMONAPRIDE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
1353 | 1880 | 85 | 3H-YM 09151-2 | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-NEMONAPRIDE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-YM 09151-2 | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-NEMONAPRIDE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-YM 09151-2 | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-NEMONAPRIDE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-YM 09151-2 | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-NEMONAPRIDE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-YM 09151-2 | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
2726 | 906 | 64 | 3H-SCH23390 | -10 | 72 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-SCH23390 | -10 | 72 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-SCH23390 | -10 | 72 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-SCH23390 | -10 | 72 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-SCH23390 | -10 | 72 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
135409468 | 2004 | 63 | UNDEFINED | -18 | 40 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
333 | 2004 | 63 | UNDEFINED | -18 | 40 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
CHEMBL845 | 2004 | 63 | UNDEFINED | -18 | 40 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
None | 214240 | 0 | 3H-SPIPERONE | 3 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 310 | 3 | 0 | 2 | 4.8 | CN(C)CCC=C1C2=CC=CC=C2C=NC3=C1C=C(C=C3)Cl | None | ||
1577 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | UNDEFINED | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2337 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
2337 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-SPIPERONE | -173 | 62 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
1577 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-NEMONAPRIDE | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
11954259 | 214201 | 0 | 3H-NMSP | -676 | 43 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
135398737 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
279 | 1631 | 26 | UNDEFINED | -4 | 17 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 3.1 | CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 | None | ||
49381 | 1631 | 26 | UNDEFINED | -4 | 17 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 3.1 | CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 | None | ||
CHEMBL63756 | 1631 | 26 | UNDEFINED | -4 | 17 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 3.1 | CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2 | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
21830793 | 91403 | 5 | 3H-8-OH-DPAT | -144 | 46 | Bovine | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | ||
CHEMBL2413154 | 91403 | 5 | 3H-8-OH-DPAT | -144 | 46 | Bovine | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | ||
44578445 | 180997 | 0 | UNDEFINED | -13 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 352 | 6 | 0 | 3 | 4.1 | O=C(CCCN1CC2CCC(C1)N2c1ccccc1)c1ccc(F)cc1 | None | ||
CHEMBL476933 | 180997 | 0 | UNDEFINED | -13 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 352 | 6 | 0 | 3 | 4.1 | O=C(CCCN1CC2CCC(C1)N2c1ccccc1)c1ccc(F)cc1 | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
1353 | 1880 | 85 | R-SAT | -3 | 85 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | R-SAT | -3 | 85 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | R-SAT | -3 | 85 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | R-SAT | -3 | 85 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | R-SAT | -3 | 85 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
44134711 | 214215 | 0 | 3H-SPIPERONE | -275 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 340 | 6 | 2 | 4 | 2.8 | CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl | None | ||
100 | 3745 | 52 | 3H-YM 09151-2 | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-YM 09151-2 | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-YM 09151-2 | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-YM 09151-2 | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-YM 09151-2 | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2337 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
54477 | 84230 | 34 | 3H-NEMONAPRIDE | -14 | 22 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | 3H-NEMONAPRIDE | -14 | 22 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
2337 | 3205 | 72 | 3H-N-Methylspiperone | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-N-Methylspiperone | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-N-Methylspiperone | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-N-Methylspiperone | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-N-Methylspiperone | -114 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
None | 214880 | 0 | UNDEFINED | -102 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 453 | 10 | 0 | 7 | 4.2 | CCOC1=CC=CC=C1N2CCN(CC2)CCCC3CC(=NO3)C4=CC(=C(C=C4)OC)OC | None | ||
2726 | 906 | 64 | 3H-NEMONAPRIDE | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-NEMONAPRIDE | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-NEMONAPRIDE | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-NEMONAPRIDE | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-NEMONAPRIDE | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
1212 | 1632 | 45 | 3H-NEMONAPRIDE | -77 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | 3H-NEMONAPRIDE | -77 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | 3H-NEMONAPRIDE | -77 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | 3H-NEMONAPRIDE | -77 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | 3H-NEMONAPRIDE | -77 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
65750 | 214699 | 0 | R-SAT | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 346 | 6 | 0 | 3 | 5.7 | CCN(CC)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl | None | ||
15387 | 214209 | 0 | 3H-SPIPERONE | -33 | 23 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
243 | 3153 | 85 | 3H-SPIPERONE | -12 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
3052762 | 3153 | 85 | 3H-SPIPERONE | -12 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
3502 | 3153 | 85 | 3H-SPIPERONE | -12 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
CHEMBL117287 | 3153 | 85 | 3H-SPIPERONE | -12 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
DB06480 | 3153 | 85 | 3H-SPIPERONE | -12 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
179 | 396 | 107 | 3H-NMSP | -50 | 50 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
2159 | 396 | 107 | 3H-NMSP | -50 | 50 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
963 | 396 | 107 | 3H-NMSP | -50 | 50 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
CHEMBL243712 | 396 | 107 | 3H-NMSP | -50 | 50 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
DB06288 | 396 | 107 | 3H-NMSP | -50 | 50 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
3033769 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
2726 | 906 | 64 | 3H-NMSP | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2726 | 906 | 64 | R-SAT | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-NMSP | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | R-SAT | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-NMSP | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | R-SAT | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-NMSP | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | R-SAT | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-NMSP | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | R-SAT | -8 | 72 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
1830 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
1830 | 2552 | 39 | UNDEFINED | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
207 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
207 | 2552 | 39 | UNDEFINED | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
23897 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
23897 | 2552 | 39 | UNDEFINED | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
CHEMBL460 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
CHEMBL460 | 2552 | 39 | UNDEFINED | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
DB01618 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
DB01618 | 2552 | 39 | UNDEFINED | -120 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
3033769 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3033769 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-SPIPERONE | -288 | 18 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
54477 | 84230 | 34 | 3H-SPIPERONE | -14 | 22 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | 3H-SPIPERONE | -14 | 22 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
9906978 | 42466 | 1 | UNDEFINED | 1 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
CHEMBL150161 | 42466 | 1 | UNDEFINED | 1 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
3294 | 1975 | 106 | 3H-SPIPERONE | -11 | 44 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
71360 | 1975 | 106 | 3H-SPIPERONE | -11 | 44 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
87 | 1975 | 106 | 3H-SPIPERONE | -11 | 44 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
CHEMBL14376 | 1975 | 106 | 3H-SPIPERONE | -11 | 44 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
DB04946 | 1975 | 106 | 3H-SPIPERONE | -11 | 44 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
100 | 3745 | 52 | 3H-NEMONAPRIDE | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-NEMONAPRIDE | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-NEMONAPRIDE | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-NEMONAPRIDE | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-NEMONAPRIDE | -8 | 55 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
242 | 467 | 117 | 3H-Methylspiperone | -87 | 51 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
34 | 467 | 117 | 3H-Methylspiperone | -87 | 51 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
60795 | 467 | 117 | 3H-Methylspiperone | -87 | 51 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL1112 | 467 | 117 | 3H-Methylspiperone | -87 | 51 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB01238 | 467 | 117 | 3H-Methylspiperone | -87 | 51 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
135398745 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-SPIPERONE | -10 | 65 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
4249 | 77814 | 30 | R-SAT | -7 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 355 | 6 | 1 | 3 | 4.1 | Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | None | ||
CHEMBL2104700 | 77814 | 30 | R-SAT | -7 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 355 | 6 | 1 | 3 | 4.1 | Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | None | ||
44134711 | 214215 | 0 | 3H-SPIPERONE | -275 | 13 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 340 | 6 | 2 | 4 | 2.8 | CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl | None | ||
44591042 | 176237 | 0 | UNDEFINED | -15 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 380 | 4 | 2 | 2 | 4.9 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCc1c[nH]c2ccccc12 | None | ||
CHEMBL460854 | 176237 | 0 | UNDEFINED | -15 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 380 | 4 | 2 | 2 | 4.9 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCc1c[nH]c2ccccc12 | None | ||
2435 | 3533 | 78 | R-SAT | -10 | 48 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | R-SAT | -10 | 48 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | R-SAT | -10 | 48 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | R-SAT | -10 | 48 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | R-SAT | -10 | 48 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
135398737 | 944 | 89 | 3H-YM 09151-2 | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-YM 09151-2 | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-YM 09151-2 | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-YM 09151-2 | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-YM 09151-2 | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
163839 | 2910 | 0 | 3H-Methylspiperone | -15 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 391 | 6 | 1 | 4 | 3.7 | Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 | None | ||
268 | 2910 | 0 | 3H-Methylspiperone | -15 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 391 | 6 | 1 | 4 | 3.7 | Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 | None | ||
CHEMBL55171 | 2910 | 0 | 3H-Methylspiperone | -15 | 7 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 391 | 6 | 1 | 4 | 3.7 | Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 | None | ||
54477 | 84230 | 34 | 3H-SPIPERONE | -14 | 22 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
54477 | 84230 | 34 | UNDEFINED | -14 | 22 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
54477 | 84230 | 34 | 3H-SPIPERONE | -38 | 22 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | 3H-SPIPERONE | -14 | 22 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | UNDEFINED | -14 | 22 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | 3H-SPIPERONE | -38 | 22 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
31101 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
35 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
403 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
CHEMBL493 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
DB01200 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
135398737 | 944 | 89 | 3H-Methylspiperone | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-Methylspiperone | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-Methylspiperone | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-Methylspiperone | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-Methylspiperone | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
1613 | 2316 | 44 | 3H-YM 09151-2 | -2 | 44 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-YM 09151-2 | -2 | 44 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-YM 09151-2 | -2 | 44 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-YM 09151-2 | -2 | 44 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-YM 09151-2 | -2 | 44 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
119570 | 3110 | 90 | 3H-NMSP | -10 | 40 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
2233 | 3110 | 90 | 3H-NMSP | -10 | 40 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
953 | 3110 | 90 | 3H-NMSP | -10 | 40 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
CHEMBL301265 | 3110 | 90 | 3H-NMSP | -10 | 40 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
DB00413 | 3110 | 90 | 3H-NMSP | -10 | 40 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
135398745 | 2869 | 108 | 3H-SCH23390 | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-SCH23390 | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-SCH23390 | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-SCH23390 | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
3033769 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
1353 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | UNDEFINED | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
1353 | 1880 | 85 | 3H-N-Methylspiperone | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-N-Methylspiperone | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-N-Methylspiperone | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-N-Methylspiperone | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-N-Methylspiperone | -3 | 85 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
None | 214477 | 0 | 3H-YM 09151-2 | -3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 359 | 1 | 2 | 2 | 3.7 | CC(C)(C)C(=O)NC1CC2C(CC3=C(NC4=CC=CC2=C34)Cl)N(C1)C | None | ||
3691783 | 4696 | 1 | UNDEFINED | 47 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 1 | 3 | 3.4 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)c[nH]2)cc1 | None | ||
CHEMBL103871 | 4696 | 1 | UNDEFINED | 47 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 1 | 3 | 3.4 | c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)c[nH]2)cc1 | None | ||
9906978 | 42466 | 1 | UNDEFINED | 1 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
CHEMBL150161 | 42466 | 1 | UNDEFINED | 1 | 12 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
None | 214360 | 0 | 3H-SPIPERONE | 758 | 7 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 401 | 5 | 1 | 5 | 2.2 | C1COC(C2=CC=CC=C21)CCN3CCN(CC3)C4=CC=C(C=C4)S(=O)(=O)N | None | ||
2470 | 3596 | 46 | R-SAT | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | R-SAT | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | R-SAT | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | R-SAT | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | R-SAT | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
100 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | 3H-SPIPERONE | -3 | 55 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
135398737 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIROPERIDOL | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
1212 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
135398745 | 2869 | 108 | 3H-NEMONAPRIDE | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-NEMONAPRIDE | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-NEMONAPRIDE | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-NEMONAPRIDE | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
16362 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
2172 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
90 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
CHEMBL1423 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
DB01100 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
5074 | 3280 | 75 | UNDEFINED | -56 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | ||
97 | 3280 | 75 | UNDEFINED | -56 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | ||
CHEMBL267777 | 3280 | 75 | UNDEFINED | -56 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | ||
DB12693 | 3280 | 75 | UNDEFINED | -56 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | None | ||
16106 | 117643 | 28 | 3H-SPIPERONE | -1 | 11 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
16106 | 117643 | 28 | UNDEFINED | -1 | 11 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
CHEMBL340801 | 117643 | 28 | 3H-SPIPERONE | -1 | 11 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
CHEMBL340801 | 117643 | 28 | UNDEFINED | -1 | 11 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
None | 214668 | 0 | 3H-SPIPERONE | -100 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 453 | 8 | 1 | 4 | 4.6 | COC1=CC=CC=C1N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4C=C3.Cl | None | ||
2337 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
2337 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | 3H-SPIPERONE | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | UNDEFINED | -114 | 62 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
None | 215425 | 0 | UNDEFINED | -120 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 366 | 3 | 2 | 2 | 4.8 | C1CC2CC(CC1N2CC3=CNC4=CC=CC=C43)(C5=CC=C(C=C5)Cl)O | None | ||
2202 | 3083 | 91 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
4850 | 3083 | 91 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
49 | 3083 | 91 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
CHEMBL1371770 | 3083 | 91 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
DB12478 | 3083 | 91 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
135398745 | 2869 | 108 | R-SAT | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | R-SAT | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | R-SAT | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | R-SAT | -10 | 65 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
33630 | 178379 | 94 | 3H-SPIPERONE | -5 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
CHEMBL47050 | 178379 | 94 | 3H-SPIPERONE | -5 | 27 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
25139180 | 183759 | 0 | UNDEFINED | -10 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 490 | 10 | 1 | 2 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1 | None | ||
CHEMBL484357 | 183759 | 0 | UNDEFINED | -10 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 490 | 10 | 1 | 2 | 7.1 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1 | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
209 | 3008 | 94 | 3H-SPIPERONE | -30 | 23 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2113 | 3008 | 94 | 3H-SPIPERONE | -30 | 23 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4748 | 3008 | 94 | 3H-SPIPERONE | -30 | 23 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL567 | 3008 | 94 | 3H-SPIPERONE | -30 | 23 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00850 | 3008 | 94 | 3H-SPIPERONE | -30 | 23 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2865 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
59 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
60854 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL708 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
DB00246 | 4079 | 67 | UNDEFINED | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
214 | 3799 | 52 | 3H-YM 09151-2 | -33 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | 3H-YM 09151-2 | -33 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | 3H-YM 09151-2 | -33 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | 3H-YM 09151-2 | -33 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | 3H-YM 09151-2 | -33 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | 3H-YM 09151-2 | -33 | 29 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2865 | 4079 | 67 | 3H-N-Methylspiperone | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
59 | 4079 | 67 | 3H-N-Methylspiperone | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
60854 | 4079 | 67 | 3H-N-Methylspiperone | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL708 | 4079 | 67 | 3H-N-Methylspiperone | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
DB00246 | 4079 | 67 | 3H-N-Methylspiperone | -66 | 53 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
5567 | 42556 | 24 | R-SAT | -11 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 409 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL15023 | 42556 | 24 | R-SAT | -11 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 409 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 | None | ||
2 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
54562 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
CHEMBL240773 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
104870 | 98423 | 39 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
5374 | 98423 | 39 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
CHEMBL279085 | 98423 | 39 | 3H-SPIPERONE | -2 | 21 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
2 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
54562 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
CHEMBL240773 | 3210 | 19 | 3H-SPIPERONE | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
31101 | 720 | 39 | 3H-SPIPERONE | -489 | 35 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
35 | 720 | 39 | 3H-SPIPERONE | -489 | 35 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
403 | 720 | 39 | 3H-SPIPERONE | -489 | 35 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
CHEMBL493 | 720 | 39 | 3H-SPIPERONE | -489 | 35 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
DB01200 | 720 | 39 | 3H-SPIPERONE | -489 | 35 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
1830 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
207 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
23897 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
CHEMBL460 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
DB01618 | 2552 | 39 | 3H-SPIPERONE | -120 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
3036864 | 201066 | 16 | 3H-SPIPERONE | -14791 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
CHEMBL1256645 | 201066 | 16 | 3H-SPIPERONE | -14791 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
CHEMBL1814790 | 201066 | 16 | 3H-SPIPERONE | -14791 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
CHEMBL62 | 201066 | 16 | 3H-SPIPERONE | -14791 | 27 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
1212 | 1632 | 45 | 3H-NMSP | -77 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | 3H-NMSP | -77 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | 3H-NMSP | -77 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | 3H-NMSP | -77 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | 3H-NMSP | -77 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
54477 | 84230 | 34 | 3H-SPIPERONE | -14 | 22 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | 3H-SPIPERONE | -14 | 22 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
2726 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
31101 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
35 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
403 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
CHEMBL493 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
DB01200 | 720 | 39 | 3H-SPIPERONE | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
6917970 | 3635 | 54 | 3H-NMSP | -851 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | ||
8370 | 3635 | 54 | 3H-NMSP | -851 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | ||
CHEMBL487387 | 3635 | 54 | 3H-NMSP | -851 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | ||
37459 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
62 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
CHEMBL8514 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
135398737 | 944 | 89 | 3H-NMSP | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-NMSP | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-NMSP | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-NMSP | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-NMSP | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
214 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
None | 214668 | 0 | 3H-SPIPERONE | -100 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 453 | 8 | 1 | 4 | 4.6 | COC1=CC=CC=C1N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4C=C3.Cl | None | ||
None | 214479 | 0 | 3H-SPIPERONE | 1 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 226 | 0 | 2 | 2 | 1.4 | C1CCC(=O)NCCCCCC(=O)NCC1 | None | ||
186 | 1777 | 47 | 3H-NMSP | -512 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
71781 | 1777 | 47 | 3H-NMSP | -512 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
CHEMBL18972 | 1777 | 47 | 3H-NMSP | -512 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
30137 | 2833 | 0 | 3H-SPIPERONE | -10 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | None | ||
8594 | 2833 | 0 | 3H-SPIPERONE | -10 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | None | ||
934 | 2833 | 0 | 3H-SPIPERONE | -10 | 10 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | None | ||
2470 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | 3H-SPIPERONE | -20 | 59 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
25139181 | 183760 | 0 | UNDEFINED | -2 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | None | ||
CHEMBL484358 | 183760 | 0 | UNDEFINED | -2 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 414 | 10 | 1 | 2 | 5.7 | C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1 | None | ||
25058166 | 214181 | 0 | 3H-SPIPERONE | -8 | 26 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
6852389 | 214181 | 0 | 3H-SPIPERONE | -8 | 26 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
2389 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
37459 | 735 | 10 | UNDEFINED | -123 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
62 | 735 | 10 | UNDEFINED | -123 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
CHEMBL8514 | 735 | 10 | UNDEFINED | -123 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
71240 | 205983 | 10 | R-SAT | -9 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 408 | 4 | 1 | 3 | 4.0 | OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1 | None | ||
CHEMBL95636 | 205983 | 10 | R-SAT | -9 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 408 | 4 | 1 | 3 | 4.0 | OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1 | None | ||
1588 | 2294 | 24 | 3H-SPIPERONE | -23 | 43 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
28864 | 2294 | 24 | 3H-SPIPERONE | -23 | 43 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
43 | 2294 | 24 | 3H-SPIPERONE | -23 | 43 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL157138 | 2294 | 24 | 3H-SPIPERONE | -23 | 43 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB00589 | 2294 | 24 | 3H-SPIPERONE | -23 | 43 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
1613 | 2316 | 44 | 3H-SPIROPERIDOL | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-SPIROPERIDOL | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-SPIROPERIDOL | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-SPIROPERIDOL | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-SPIROPERIDOL | -2 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
191 | 399 | 92 | R-SAT | -8 | 28 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
201 | 399 | 92 | R-SAT | -8 | 28 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
2170 | 399 | 92 | R-SAT | -8 | 28 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
CHEMBL1113 | 399 | 92 | R-SAT | -8 | 28 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
DB00543 | 399 | 92 | R-SAT | -8 | 28 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
37459 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
62 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
CHEMBL8514 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
135398737 | 944 | 89 | 3H-NEMONAPRIDE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-NEMONAPRIDE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-NEMONAPRIDE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-NEMONAPRIDE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-NEMONAPRIDE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
214 | 3799 | 52 | 3H-NEMONAPRIDE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | 3H-NEMONAPRIDE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | 3H-NEMONAPRIDE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | 3H-NEMONAPRIDE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | 3H-NEMONAPRIDE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | 3H-NEMONAPRIDE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
11545813 | 180612 | 0 | UNDEFINED | 4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | None | ||
CHEMBL476109 | 180612 | 0 | UNDEFINED | 4 | 7 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | None | ||
15387 | 214209 | 0 | 3H-SPIPERONE | -35 | 23 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
15387 | 214209 | 0 | UNDEFINED | -35 | 23 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
3033769 | 3229 | 54 | 3H-NEMONAPRIDE | -562 | 18 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-NEMONAPRIDE | -562 | 18 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-NEMONAPRIDE | -562 | 18 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-NEMONAPRIDE | -562 | 18 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-NEMONAPRIDE | -562 | 18 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
25058166 | 214181 | 0 | 3H-SPIPERONE | -8 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
6852389 | 214181 | 0 | 3H-SPIPERONE | -8 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
None | 214879 | 0 | UNDEFINED | -69 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 535 | 10 | 0 | 6 | 5.7 | COC1=C(C=C(C=C1)C2=NOC(C2)CCCN3CCN(CC3)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)OC | None | ||
16362 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
2172 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
90 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
CHEMBL1423 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
DB01100 | 3076 | 67 | 3H-SPIPERONE | -186 | 29 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
1830 | 2552 | 39 | 3H-NEMONAPRIDE | -120 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
207 | 2552 | 39 | 3H-NEMONAPRIDE | -120 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
23897 | 2552 | 39 | 3H-NEMONAPRIDE | -120 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
CHEMBL460 | 2552 | 39 | 3H-NEMONAPRIDE | -120 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
DB01618 | 2552 | 39 | 3H-NEMONAPRIDE | -120 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
214 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
214 | 3799 | 52 | UNDEFINED | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | UNDEFINED | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | UNDEFINED | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | UNDEFINED | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | UNDEFINED | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | 3H-SPIPERONE | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | UNDEFINED | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
25058166 | 214181 | 0 | 3H-YM 09151-2 | -8 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
6852389 | 214181 | 0 | 3H-YM 09151-2 | -8 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
1257 | 214628 | 0 | 3H-SPIPERONE | 1 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCCC2C1CC3=C(C2)NN=C3 | None | ||
209 | 3008 | 94 | 3H-NEMONAPRIDE | -30 | 23 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2113 | 3008 | 94 | 3H-NEMONAPRIDE | -30 | 23 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4748 | 3008 | 94 | 3H-NEMONAPRIDE | -30 | 23 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL567 | 3008 | 94 | 3H-NEMONAPRIDE | -30 | 23 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00850 | 3008 | 94 | 3H-NEMONAPRIDE | -30 | 23 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2448 | 214184 | 0 | R-SAT | -13 | 17 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 419 | 6 | 1 | 3 | 4.5 | C1CN(CCC1(C2=CC=C(C=C2)Br)O)CCCC(=O)C3=CC=C(C=C3)F | None | ||
None | 214879 | 0 | UNDEFINED | -69 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 535 | 10 | 0 | 6 | 5.7 | COC1=C(C=C(C=C1)C2=NOC(C2)CCCN3CCN(CC3)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)OC | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
4209 | 3114 | 71 | None | -1318 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | ||
4893 | 3114 | 71 | None | -1318 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | ||
503 | 3114 | 71 | None | -1318 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | ||
5385 | 3114 | 71 | None | -1318 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | ||
CHEMBL2 | 3114 | 71 | None | -1318 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | ||
DB00457 | 3114 | 71 | None | -1318 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
1353 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
3559 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
86 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
CHEMBL54 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -3 | 85 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
DB00502 | 1880 | 85 | 3H-SPIPERONE | -4 | 85 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
5280343 | 187691 | 119 | None | 1 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL1520590 | 187691 | 119 | None | 1 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL50 | 187691 | 119 | None | 1 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
2812 | 4711 | 96 | None | -39 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
CHEMBL104 | 4711 | 96 | None | -39 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
2601 | 3721 | 30 | 3H-YM 09151-2 | -7 | 21 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
443951 | 3721 | 30 | 3H-YM 09151-2 | -7 | 21 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
56 | 3721 | 30 | 3H-YM 09151-2 | -7 | 21 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL73151 | 3721 | 30 | 3H-YM 09151-2 | -7 | 21 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB13399 | 3721 | 30 | 3H-YM 09151-2 | -7 | 21 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
176 | 394 | 63 | None | -4 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
2157 | 394 | 63 | None | -4 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
2566 | 394 | 63 | None | -4 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
CHEMBL633 | 394 | 63 | None | -4 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
DB01118 | 394 | 63 | None | -4 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
4189 | 205195 | 91 | None | -33 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
CHEMBL1559 | 205195 | 91 | None | -33 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
CHEMBL91 | 205195 | 91 | None | -33 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
13091268 | 77845 | 0 | UNDEFINED | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL210578 | 77845 | 0 | UNDEFINED | -8 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
2274 | 3124 | 53 | UNDEFINED | -56 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4917 | 3124 | 53 | UNDEFINED | -56 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
7279 | 3124 | 53 | UNDEFINED | -56 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL728 | 3124 | 53 | UNDEFINED | -56 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00433 | 3124 | 53 | UNDEFINED | -56 | 32 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
1016 | 3690 | 75 | None | -28 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
2561 | 3690 | 75 | None | -28 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
2733526 | 3690 | 75 | None | -28 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
5384 | 3690 | 75 | None | -28 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
CHEMBL83 | 3690 | 75 | None | -28 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
DB00675 | 3690 | 75 | None | -28 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
54477 | 84230 | 34 | None | -14 | 22 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
CHEMBL22242 | 84230 | 34 | None | -14 | 22 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
3198 | 203802 | 73 | None | -26 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | ||
CHEMBL1201049 | 203802 | 73 | None | -26 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | ||
CHEMBL808 | 203802 | 73 | None | -26 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | ||
1499 | 2060 | 43 | None | -18 | 17 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
3779 | 2060 | 43 | None | -18 | 17 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
536 | 2060 | 43 | None | -18 | 17 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
CHEMBL434 | 2060 | 43 | None | -18 | 17 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
DB01064 | 2060 | 43 | None | -18 | 17 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
7077 | 66625 | 24 | None | -10 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | None | ||
CHEMBL186720 | 66625 | 24 | None | -10 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | None | ||
CHEMBL3925724 | 66625 | 24 | None | -10 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | None | ||
1830 | 2552 | 39 | R-SAT | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
207 | 2552 | 39 | R-SAT | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
23897 | 2552 | 39 | R-SAT | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
CHEMBL460 | 2552 | 39 | R-SAT | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
DB01618 | 2552 | 39 | R-SAT | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
1830 | 2552 | 39 | None | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
207 | 2552 | 39 | None | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
23897 | 2552 | 39 | None | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
CHEMBL460 | 2552 | 39 | None | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
DB01618 | 2552 | 39 | None | -120 | 27 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
2247 | 502 | 77 | None | -63 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
249 | 502 | 77 | None | -63 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
2603 | 502 | 77 | None | -63 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
CHEMBL296419 | 502 | 77 | None | -63 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
DB00637 | 502 | 77 | None | -63 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2337 | 3205 | 72 | None | -114 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
50 | 3205 | 72 | None | -114 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
5002 | 3205 | 72 | None | -114 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
CHEMBL716 | 3205 | 72 | None | -114 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
DB01224 | 3205 | 72 | None | -114 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
103 | 4089 | 56 | 3H-SPIPERONE | -4 | 53 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2875 | 4089 | 56 | 3H-SPIPERONE | -4 | 53 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
5736 | 4089 | 56 | 3H-SPIPERONE | -4 | 53 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL285802 | 4089 | 56 | 3H-SPIPERONE | -4 | 53 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB09225 | 4089 | 56 | 3H-SPIPERONE | -4 | 53 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
219050 | 3321 | 21 | 3H-SPIPERONE | -58 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | ||
52 | 3321 | 21 | 3H-SPIPERONE | -58 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | ||
CHEMBL431367 | 3321 | 21 | 3H-SPIPERONE | -58 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | ||
3117 | 206106 | 100 | None | -2 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | None | ||
CHEMBL964 | 206106 | 100 | None | -2 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | None | ||
1212 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
1212 | 1632 | 45 | UNDEFINED | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | UNDEFINED | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | UNDEFINED | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | UNDEFINED | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | 3H-SPIPERONE | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | UNDEFINED | -77 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
135398745 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | UNDEFINED | -10 | 65 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
None | 214880 | 0 | UNDEFINED | -102 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 453 | 10 | 0 | 7 | 4.2 | CCOC1=CC=CC=C1N2CCN(CC2)CCCC3CC(=NO3)C4=CC(=C(C=C4)OC)OC | None | ||
37459 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
62 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
CHEMBL8514 | 735 | 10 | 3H-SPIPERONE | -123 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
242 | 467 | 117 | 3H-NMSP | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
34 | 467 | 117 | 3H-NMSP | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
60795 | 467 | 117 | 3H-NMSP | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL1112 | 467 | 117 | 3H-NMSP | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB01238 | 467 | 117 | 3H-NMSP | -87 | 51 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
44591088 | 188991 | 0 | UNDEFINED | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 372 | 6 | 0 | 3 | 4.6 | O=C(CCCN1CC2CC1N(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL514591 | 188991 | 0 | UNDEFINED | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 372 | 6 | 0 | 3 | 4.6 | O=C(CCCN1CC2CC1N(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
242 | 467 | 117 | 3H-NMSP | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
34 | 467 | 117 | 3H-NMSP | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
60795 | 467 | 117 | 3H-NMSP | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL1112 | 467 | 117 | 3H-NMSP | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB01238 | 467 | 117 | 3H-NMSP | -117 | 51 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -28 | 25 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
44578446 | 180998 | 0 | UNDEFINED | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 372 | 6 | 0 | 3 | 4.4 | O=C(CCCN1CC2CC1CN2c1ccc(Cl)cc1)c1ccc(F)cc1 | None | ||
CHEMBL476934 | 180998 | 0 | UNDEFINED | -3 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 372 | 6 | 0 | 3 | 4.4 | O=C(CCCN1CC2CC1CN2c1ccc(Cl)cc1)c1ccc(F)cc1 | None | ||
9429 | 214381 | 0 | 3H-SPIPERONE | -251 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 638 | 6 | 2 | 10 | 2.2 | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O | None | ||
135398737 | 944 | 89 | 3H-N-Methylspiperone | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-N-Methylspiperone | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-N-Methylspiperone | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-N-Methylspiperone | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-N-Methylspiperone | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
5311189 | 203133 | 4 | 3H-NMSP | -1 | 27 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | ||
CHEMBL7549 | 203133 | 4 | 3H-NMSP | -1 | 27 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | ||
135398737 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | UNDEFINED | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
1577 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | R-SAT | -8 | 25 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
115237 | 55296 | 113 | 3H-NMSP | -15 | 54 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
CHEMBL1621 | 55296 | 113 | 3H-NMSP | -15 | 54 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
185 | 3943 | 54 | 3H-SPIPERONE | -7244 | 37 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
5311271 | 3943 | 54 | 3H-SPIPERONE | -7244 | 37 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
CHEMBL74355 | 3943 | 54 | 3H-SPIPERONE | -7244 | 37 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
DB16351 | 3943 | 54 | 3H-SPIPERONE | -7244 | 37 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
202478 | 202981 | 15 | 3H-YM 09151-2 | -7 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | ||
CHEMBL7393 | 202981 | 15 | 3H-YM 09151-2 | -7 | 25 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | ||
1621 | 2396 | 16 | 3H-NMSP | -181 | 44 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
17 | 2396 | 16 | 3H-NMSP | -181 | 44 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
5761 | 2396 | 16 | 3H-NMSP | -181 | 44 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL263881 | 2396 | 16 | 3H-NMSP | -181 | 44 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB04829 | 2396 | 16 | 3H-NMSP | -181 | 44 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
22065962 | 176222 | 0 | UNDEFINED | 20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 294 | 3 | 1 | 5 | 1.7 | c1cnc(N2CCN(Cc3c[nH]c4ncccc34)CC2)nc1 | None | ||
CHEMBL460644 | 176222 | 0 | UNDEFINED | 20 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 294 | 3 | 1 | 5 | 1.7 | c1cnc(N2CCN(Cc3c[nH]c4ncccc34)CC2)nc1 | None | ||
None | 214590 | 0 | 3H-SPIPERONE | -74 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 451 | 8 | 2 | 4 | 3.2 | CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C | None | ||
10060538 | 4508 | 6 | 3H-SPIPERONE | -3890 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 247 | 2 | 1 | 3 | 2.5 | CCCN1CCOC2c3cc(O)ccc3CCC21 | None | ||
CHEMBL102582 | 4508 | 6 | 3H-SPIPERONE | -3890 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 247 | 2 | 1 | 3 | 2.5 | CCCN1CCOC2c3cc(O)ccc3CCC21 | None | ||
2105 | 3005 | 34 | 3H-SPIPERONE | -48 | 33 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
47811 | 3005 | 34 | 3H-SPIPERONE | -48 | 33 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
48 | 3005 | 34 | 3H-SPIPERONE | -48 | 33 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
CHEMBL531 | 3005 | 34 | 3H-SPIPERONE | -48 | 33 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
DB01186 | 3005 | 34 | 3H-SPIPERONE | -48 | 33 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
44591087 | 175177 | 0 | UNDEFINED | -1 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 366 | 3 | 1 | 3 | 4.5 | Clc1ccc(N2CCC3CCC(C2)N3Cc2c[nH]c3ncccc23)cc1 | None | ||
CHEMBL458342 | 175177 | 0 | UNDEFINED | -1 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 366 | 3 | 1 | 3 | 4.5 | Clc1ccc(N2CCC3CCC(C2)N3Cc2c[nH]c3ncccc23)cc1 | None | ||
33630 | 178379 | 94 | None | -13 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
CHEMBL47050 | 178379 | 94 | None | -13 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
2402 | 3318 | 58 | None | -2 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
5095 | 3318 | 58 | None | -2 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
7295 | 3318 | 58 | None | -2 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
CHEMBL589 | 3318 | 58 | None | -2 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
DB00268 | 3318 | 58 | None | -2 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
681 | 1437 | 65 | UNDEFINED | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
940 | 1437 | 65 | UNDEFINED | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
947 | 1437 | 65 | UNDEFINED | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
CHEMBL59 | 1437 | 65 | UNDEFINED | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
DB00988 | 1437 | 65 | UNDEFINED | -2 | 38 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
3191 | 102385 | 93 | None | -10 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
CHEMBL305660 | 102385 | 93 | None | -10 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
15387 | 214209 | 0 | None | -35 | 23 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
31101 | 720 | 39 | None | -186 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
35 | 720 | 39 | None | -186 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
403 | 720 | 39 | None | -186 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
CHEMBL493 | 720 | 39 | None | -186 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
DB01200 | 720 | 39 | None | -186 | 35 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
212 | 3746 | 43 | UNDEFINED | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
2639 | 3746 | 43 | UNDEFINED | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
941651 | 3746 | 43 | UNDEFINED | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
CHEMBL1201 | 3746 | 43 | UNDEFINED | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
DB01623 | 3746 | 43 | UNDEFINED | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
104870 | 98423 | 39 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
5374 | 98423 | 39 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
CHEMBL279085 | 98423 | 39 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
1153 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
12668023 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
30026874 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
30026875 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
3341 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
6603851 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
933 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
939 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
985 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
CHEMBL1160786 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
CHEMBL1161520 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
CHEMBL588 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
DB00800 | 1598 | 53 | None | -16 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | ||
2202 | 3083 | 91 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
4850 | 3083 | 91 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
49 | 3083 | 91 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
CHEMBL1371770 | 3083 | 91 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
DB12478 | 3083 | 91 | None | -2 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
10065083 | 31887 | 1 | UNDEFINED | 1 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL140872 | 31887 | 1 | UNDEFINED | 1 | 10 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | None | ||
46 | 2861 | 0 | R-SAT | -33 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | None | ||
71351 | 2861 | 0 | R-SAT | -33 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | None | ||
CHEMBL2104619 | 2861 | 0 | R-SAT | -33 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | None | ||
DB06229 | 2861 | 0 | R-SAT | -33 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 420 | 4 | 0 | 6 | 4.0 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C | None | ||
11653679 | 180609 | 1 | UNDEFINED | 3 | 11 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL476108 | 180609 | 1 | UNDEFINED | 3 | 11 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
242 | 467 | 117 | None | -117 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
34 | 467 | 117 | None | -117 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
60795 | 467 | 117 | None | -117 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL1112 | 467 | 117 | None | -117 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB01238 | 467 | 117 | None | -117 | 51 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
212 | 3746 | 43 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
2639 | 3746 | 43 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
941651 | 3746 | 43 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
CHEMBL1201 | 3746 | 43 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
DB01623 | 3746 | 43 | None | -6 | 25 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
11154555 | 788 | 57 | None | -501 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
5037 | 788 | 57 | None | -501 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
7671 | 788 | 57 | None | -501 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL2028019 | 788 | 57 | None | -501 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL3085826 | 788 | 57 | None | -501 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB06016 | 788 | 57 | None | -501 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
21302490 | 112308 | 26 | None | -12 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 393 | 5 | 0 | 4 | 3.9 | CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 | None | ||
CHEMBL3233142 | 112308 | 26 | None | -12 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 393 | 5 | 0 | 4 | 3.9 | CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 | None | ||
CHEMBL3306803 | 112308 | 26 | None | -12 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 393 | 5 | 0 | 4 | 3.9 | CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 | None | ||
135398745 | 2869 | 108 | 3H-N-Methylspiperone | -10 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-N-Methylspiperone | -10 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-N-Methylspiperone | -10 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-N-Methylspiperone | -10 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
6852400 | 214160 | 0 | 3H-SPIPERONE | -794 | 21 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
73759726 | 214160 | 0 | 3H-SPIPERONE | -794 | 21 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
25139331 | 169361 | 0 | UNDEFINED | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 310 | 9 | 2 | 2 | 3.9 | CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1 | None | ||
CHEMBL444128 | 169361 | 0 | UNDEFINED | 1 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 310 | 9 | 2 | 2 | 3.9 | CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1 | None | ||
3033769 | 3229 | 54 | 3H-RACLOPRIDE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3033769 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3033769 | 3229 | 54 | UNDEFINED | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-RACLOPRIDE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
3299 | 3229 | 54 | UNDEFINED | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-RACLOPRIDE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
94 | 3229 | 54 | UNDEFINED | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-RACLOPRIDE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
CHEMBL8809 | 3229 | 54 | UNDEFINED | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-RACLOPRIDE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | 3H-SPIPERONE | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
DB12518 | 3229 | 54 | UNDEFINED | -562 | 18 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
44134711 | 214215 | 0 | 3H-Methylspiperone | -724 | 13 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 340 | 6 | 2 | 4 | 2.8 | CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl | None | ||
None | 214361 | 0 | 3H-YM 09151-2 | -8 | 5 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 273 | 6 | 0 | 2 | 4.3 | CCCN(CCC)C1C=CC2=C(C1C)C=CC=C2OC | None | ||
25139481 | 184257 | 0 | UNDEFINED | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 392 | 10 | 1 | 2 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1 | None | ||
CHEMBL485227 | 184257 | 0 | UNDEFINED | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 392 | 10 | 1 | 2 | 5.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1 | None | ||
25139477 | 183663 | 0 | UNDEFINED | -15 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 486 | 10 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1 | None | ||
CHEMBL483593 | 183663 | 0 | UNDEFINED | -15 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 486 | 10 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1 | None | ||
44123782 | 189009 | 0 | UNDEFINED | -6 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 338 | 3 | 1 | 3 | 3.7 | Clc1ccc(N2CC3CC2CN3Cc2c[nH]c3ncccc23)cc1 | None | ||
CHEMBL514747 | 189009 | 0 | UNDEFINED | -6 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 338 | 3 | 1 | 3 | 3.7 | Clc1ccc(N2CC3CC2CN3Cc2c[nH]c3ncccc23)cc1 | None | ||
2477 | 734 | 54 | None | -1 | 28 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
36 | 734 | 54 | None | -1 | 28 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
437 | 734 | 54 | None | -1 | 28 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
CHEMBL49 | 734 | 54 | None | -1 | 28 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
DB00490 | 734 | 54 | None | -1 | 28 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
2389 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
2389 | 3279 | 114 | 3H-SPIROPERIDOL | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SPIROPERIDOL | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SPIROPERIDOL | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SPIROPERIDOL | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SPIPERONE | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SPIROPERIDOL | -21 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
1212 | 1632 | 45 | R-SAT | -77 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | R-SAT | -77 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | R-SAT | -77 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | R-SAT | -77 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | R-SAT | -77 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2274 | 3124 | 53 | None | -56 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4917 | 3124 | 53 | None | -56 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
7279 | 3124 | 53 | None | -56 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL728 | 3124 | 53 | None | -56 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00433 | 3124 | 53 | None | -56 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
1621 | 2396 | 16 | None | -64 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
17 | 2396 | 16 | None | -64 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
5761 | 2396 | 16 | None | -64 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL263881 | 2396 | 16 | None | -64 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB04829 | 2396 | 16 | None | -64 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
2105 | 3005 | 34 | None | -48 | 33 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
47811 | 3005 | 34 | None | -48 | 33 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
48 | 3005 | 34 | None | -48 | 33 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
CHEMBL531 | 3005 | 34 | None | -48 | 33 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
DB01186 | 3005 | 34 | None | -48 | 33 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
2407 | 3320 | 73 | None | -30 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | ||
59227 | 3320 | 73 | None | -30 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | ||
941 | 3320 | 73 | None | -30 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | ||
CHEMBL1303 | 3320 | 73 | None | -30 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | ||
DB05271 | 3320 | 73 | None | -30 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | ||
115237 | 55296 | 113 | None | -15 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
CHEMBL1621 | 55296 | 113 | None | -15 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
242 | 467 | 117 | None | -87 | 51 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
34 | 467 | 117 | None | -87 | 51 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
60795 | 467 | 117 | None | -87 | 51 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
CHEMBL1112 | 467 | 117 | None | -87 | 51 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
DB01238 | 467 | 117 | None | -87 | 51 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
37 | 766 | 56 | None | -7 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | ||
460 | 766 | 56 | None | -7 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | ||
54746 | 766 | 56 | None | -7 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | ||
CHEMBL1201087 | 766 | 56 | None | -7 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | ||
DB00248 | 766 | 56 | None | -7 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | ||
135398745 | 2869 | 108 | None | -7 | 65 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | None | -7 | 65 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | None | -7 | 65 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | None | -7 | 65 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
2865 | 4079 | 67 | None | -66 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
59 | 4079 | 67 | None | -66 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
60854 | 4079 | 67 | None | -66 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
CHEMBL708 | 4079 | 67 | None | -66 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
DB00246 | 4079 | 67 | None | -66 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
49831411 | 216027 | 0 | None | -1 | 14 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 659 | 19 | 0 | 6 | 8.7 | CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12 | None | ||
49831411 | 216027 | 0 | None | -1 | 14 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 659 | 19 | 0 | 6 | 8.7 | CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12 | None | ||
214 | 3799 | 52 | None | -33 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
2740 | 3799 | 52 | None | -33 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5566 | 3799 | 52 | None | -33 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
66064 | 3799 | 52 | None | -33 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL422 | 3799 | 52 | None | -33 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00831 | 3799 | 52 | None | -33 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
103 | 4089 | 56 | None | -17 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
2875 | 4089 | 56 | None | -17 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
5736 | 4089 | 56 | None | -17 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL285802 | 4089 | 56 | None | -17 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB09225 | 4089 | 56 | None | -17 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
3389 | 215982 | 0 | None | -1 | 26 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 549 | 12 | 0 | 6 | 6.8 | CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 | None | ||
191 | 399 | 92 | None | -8 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
201 | 399 | 92 | None | -8 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
2170 | 399 | 92 | None | -8 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
CHEMBL1113 | 399 | 92 | None | -8 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
DB00543 | 399 | 92 | None | -8 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
2389 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SPIPERONE | -28 | 67 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
16106 | 117643 | 28 | None | -1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
CHEMBL340801 | 117643 | 28 | None | -1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
1212 | 1632 | 45 | None | -77 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | None | -77 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | None | -77 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | None | -77 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | None | -77 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
209 | 3008 | 94 | None | -30 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
2113 | 3008 | 94 | None | -30 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4748 | 3008 | 94 | None | -30 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL567 | 3008 | 94 | None | -30 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00850 | 3008 | 94 | None | -30 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
3294 | 1975 | 106 | None | -11 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
71360 | 1975 | 106 | None | -11 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
87 | 1975 | 106 | None | -11 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
CHEMBL14376 | 1975 | 106 | None | -11 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
DB04946 | 1975 | 106 | None | -11 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
135398737 | 944 | 89 | R-SAT | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | R-SAT | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | R-SAT | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | R-SAT | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | R-SAT | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
65750 | 214699 | 0 | None | -1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 346 | 6 | 0 | 3 | 5.7 | CCN(CC)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl | None | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | None | -8 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | None | -8 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
1443 | 1997 | 30 | None | -1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 347 | 5 | 2 | 2 | 3.6 | O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 | None | ||
33625 | 1997 | 30 | None | -1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 347 | 5 | 2 | 2 | 3.6 | O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 | None | ||
501 | 1997 | 30 | None | -1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 347 | 5 | 2 | 2 | 3.6 | O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 | None | ||
CHEMBL279516 | 1997 | 30 | None | -1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 347 | 5 | 2 | 2 | 3.6 | O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 | None | ||
DB08950 | 1997 | 30 | None | -1 | 10 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 347 | 5 | 2 | 2 | 3.6 | O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 | None | ||
2448 | 214184 | 0 | None | -13 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 419 | 6 | 1 | 3 | 4.5 | C1CN(CCC1(C2=CC=C(C=C2)Br)O)CCCC(=O)C3=CC=C(C=C3)F | None | ||
1613 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
1613 | 2316 | 44 | UNDEFINED | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | UNDEFINED | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | UNDEFINED | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | UNDEFINED | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | UNDEFINED | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
5280343 | 187691 | 119 | UNDEFINED | 1 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL1520590 | 187691 | 119 | UNDEFINED | 1 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL50 | 187691 | 119 | UNDEFINED | 1 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
5467 | 204212 | 40 | None | 6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 328 | 8 | 1 | 5 | 1.2 | CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC | None | ||
CHEMBL84158 | 204212 | 40 | None | 6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 328 | 8 | 1 | 5 | 1.2 | CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC | None | ||
16106 | 117643 | 28 | 3H-SPIPERONE | 1 | 11 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
CHEMBL340801 | 117643 | 28 | 3H-SPIPERONE | 1 | 11 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 291 | 0 | 0 | 3 | 2.9 | CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1 | None | ||
2435 | 3533 | 78 | None | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | None | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | None | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | None | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | None | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
100 | 3745 | 52 | None | -8 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
2637 | 3745 | 52 | None | -8 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
5452 | 3745 | 52 | None | -8 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
CHEMBL479 | 3745 | 52 | None | -8 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
DB00679 | 3745 | 52 | None | -8 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
135409468 | 2004 | 63 | R-SAT | -18 | 40 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
333 | 2004 | 63 | R-SAT | -18 | 40 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
CHEMBL845 | 2004 | 63 | R-SAT | -18 | 40 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
2274 | 3124 | 53 | 3H-SPIPERONE | -56 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4917 | 3124 | 53 | 3H-SPIPERONE | -56 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
7279 | 3124 | 53 | 3H-SPIPERONE | -56 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL728 | 3124 | 53 | 3H-SPIPERONE | -56 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00433 | 3124 | 53 | 3H-SPIPERONE | -56 | 32 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
15387 | 214209 | 0 | 3H-SPIPERONE | -35 | 23 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
213 | 3792 | 50 | 3H-NMSP | -3 | 43 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
2717 | 3792 | 50 | 3H-NMSP | -3 | 43 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
5533 | 3792 | 50 | 3H-NMSP | -3 | 43 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
CHEMBL621 | 3792 | 50 | 3H-NMSP | -3 | 43 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
DB00656 | 3792 | 50 | 3H-NMSP | -3 | 43 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
6450478 | 214238 | 0 | 3H-SPIPERONE | -14 | 11 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 340 | 0 | 0 | 6 | 3.4 | CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42 | None | ||
11954259 | 214201 | 0 | 3H-SPIPERONE | -257 | 43 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
5280343 | 187691 | 119 | 3H-Methylspiperone | -114 | 32 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL1520590 | 187691 | 119 | 3H-Methylspiperone | -114 | 32 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
CHEMBL50 | 187691 | 119 | 3H-Methylspiperone | -114 | 32 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
44591086 | 188990 | 0 | UNDEFINED | -61 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 367 | 3 | 2 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1c[nH]c2ncccc12 | None | ||
CHEMBL514590 | 188990 | 0 | UNDEFINED | -61 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 367 | 3 | 2 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2Cc1c[nH]c2ncccc12 | None | ||
44395709 | 174326 | 0 | UNDEFINED | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL456429 | 174326 | 0 | UNDEFINED | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
CHEMBL556361 | 174326 | 0 | UNDEFINED | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 373 | 4 | 1 | 3 | 4.2 | O=C(CN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
2389 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | None | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
1712 | 2456 | 0 | None | -2 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
4078 | 2456 | 0 | None | -2 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
7227 | 2456 | 0 | None | -2 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
CHEMBL1088 | 2456 | 0 | None | -2 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
DB00933 | 2456 | 0 | None | -2 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
135398737 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | None | -7 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
228 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
33 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
6005 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
CHEMBL53 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
DB00714 | 441 | 26 | None | -1 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | ||
1222 | 1634 | 44 | None | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3396 | 1634 | 44 | None | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
85 | 1634 | 44 | None | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL46516 | 1634 | 44 | None | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
DB04842 | 1634 | 44 | None | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
2601 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
443951 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
56 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL73151 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB13399 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
4249 | 77814 | 30 | None | -7 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 355 | 6 | 1 | 3 | 4.1 | Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | None | ||
CHEMBL2104700 | 77814 | 30 | None | -7 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 355 | 6 | 1 | 3 | 4.1 | Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1 | None | ||
2601 | 3721 | 30 | 3H-SPIPERONE | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
443951 | 3721 | 30 | 3H-SPIPERONE | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
56 | 3721 | 30 | 3H-SPIPERONE | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL73151 | 3721 | 30 | 3H-SPIPERONE | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB13399 | 3721 | 30 | 3H-SPIPERONE | -7 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
2563 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | None | ||
55 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | None | ||
91273 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | None | ||
CHEMBL274047 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | None | ||
DB12833 | 3694 | 55 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 6 | 0 | 6 | 1.4 | O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 | None | ||
11978813 | 713 | 72 | None | -10 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
5014 | 713 | 72 | None | -10 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
7672 | 713 | 72 | None | -10 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
CHEMBL2105760 | 713 | 72 | None | -10 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
DB09128 | 713 | 72 | None | -10 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
52919 | 14317 | 43 | None | -3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 529 | 15 | 0 | 4 | 8.1 | CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | None | ||
CHEMBL1200986 | 14317 | 43 | None | -3 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 529 | 15 | 0 | 4 | 8.1 | CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 | None | ||
1588 | 2294 | 24 | None | -23 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
28864 | 2294 | 24 | None | -23 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
43 | 2294 | 24 | None | -23 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
CHEMBL157138 | 2294 | 24 | None | -23 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
DB00589 | 2294 | 24 | None | -23 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
1613 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
5022 | 1621 | 67 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 390 | 4 | 1 | 4 | 3.2 | O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 | None | ||
6918248 | 1621 | 67 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 390 | 4 | 1 | 4 | 3.2 | O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 | None | ||
8182 | 1621 | 67 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 390 | 4 | 1 | 4 | 3.2 | O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 | None | ||
CHEMBL231068 | 1621 | 67 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 390 | 4 | 1 | 4 | 3.2 | O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 | None | ||
DB04908 | 1621 | 67 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 390 | 4 | 1 | 4 | 3.2 | O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 | None | ||
1524 | 2150 | 89 | None | -3 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
197 | 2150 | 89 | None | -3 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
3822 | 2150 | 89 | None | -3 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
88 | 2150 | 89 | None | -3 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
CHEMBL51 | 2150 | 89 | None | -3 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
DB12465 | 2150 | 89 | None | -3 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
2780 | 110040 | 32 | None | -4 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
CHEMBL325109 | 110040 | 32 | None | -4 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
2389 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | UNDEFINED | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
25058166 | 214181 | 0 | 3H-SPIPERONE | -8 | 26 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
6852389 | 214181 | 0 | 3H-SPIPERONE | -8 | 26 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
2389 | 3279 | 114 | 3H-N-Methylspiperone | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-N-Methylspiperone | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-N-Methylspiperone | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-N-Methylspiperone | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-N-Methylspiperone | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
16363 | 589 | 48 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
312 | 589 | 48 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
9215 | 589 | 48 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
CHEMBL297302 | 589 | 48 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
DB12867 | 589 | 48 | None | -1 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
46780481 | 107045 | 18 | None | -23 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
9903970 | 107045 | 18 | None | -23 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
CHEMBL3187365 | 107045 | 18 | None | -23 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
CHEMBL3544974 | 107045 | 18 | None | -23 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
16362 | 3076 | 67 | None | -20 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
2172 | 3076 | 67 | None | -20 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
90 | 3076 | 67 | None | -20 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
CHEMBL1423 | 3076 | 67 | None | -20 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
DB01100 | 3076 | 67 | None | -20 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
135398745 | 2869 | 108 | None | -10 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | None | -10 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | None | -10 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | None | -10 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
1222 | 1634 | 44 | R-SAT | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3396 | 1634 | 44 | R-SAT | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
85 | 1634 | 44 | R-SAT | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL46516 | 1634 | 44 | R-SAT | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
DB04842 | 1634 | 44 | R-SAT | -14 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
15387 | 214209 | 0 | 3H-NEMONAPRIDE | -35 | 23 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
44591043 | 176238 | 0 | UNDEFINED | 3 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 326 | 3 | 2 | 2 | 3.9 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)C1 | None | ||
CHEMBL460855 | 176238 | 0 | UNDEFINED | 3 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 326 | 3 | 2 | 2 | 3.9 | OC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)C1 | None | ||
None | 214241 | 0 | 3H-SPIPERONE | -1 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 411 | 6 | 1 | 3 | 3.9 | C1CCC(CC1)NC(=O)N2CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F.Cl | None | ||
2402 | 3318 | 58 | 3H-SPIPERONE | -2 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
5095 | 3318 | 58 | 3H-SPIPERONE | -2 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
7295 | 3318 | 58 | 3H-SPIPERONE | -2 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
CHEMBL589 | 3318 | 58 | 3H-SPIPERONE | -2 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
DB00268 | 3318 | 58 | 3H-SPIPERONE | -2 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
10060538 | 4508 | 6 | 3H-SPIPERONE | -3890 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 247 | 2 | 1 | 3 | 2.5 | CCCN1CCOC2c3cc(O)ccc3CCC21 | None | ||
CHEMBL102582 | 4508 | 6 | 3H-SPIPERONE | -3890 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 247 | 2 | 1 | 3 | 2.5 | CCCN1CCOC2c3cc(O)ccc3CCC21 | None | ||
None | 214684 | 0 | 3H-SPIPERONE | -467 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 160 | 1 | 0 | 2 | 2.6 | CC(=O)C1=CC2=CC=CC=C2O1 | None | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -13 | 91 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
1613 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
205 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
3964 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
CHEMBL831 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
DB00408 | 2316 | 44 | 3H-SPIPERONE | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
2389 | 3279 | 114 | 3H-SCH23390 | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
5073 | 3279 | 114 | 3H-SCH23390 | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
96 | 3279 | 114 | 3H-SCH23390 | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
CHEMBL85 | 3279 | 114 | 3H-SCH23390 | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
DB00734 | 3279 | 114 | 3H-SCH23390 | -21 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
2435 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
60149 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
98 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
CHEMBL12713 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
DB06144 | 3533 | 78 | 3H-SPIPERONE | -10 | 48 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
3168 | 9172 | 84 | None | -4 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
CHEMBL1108 | 9172 | 84 | None | -4 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
1712 | 2456 | 0 | R-SAT | -2 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
4078 | 2456 | 0 | R-SAT | -2 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
7227 | 2456 | 0 | R-SAT | -2 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
CHEMBL1088 | 2456 | 0 | R-SAT | -2 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
DB00933 | 2456 | 0 | R-SAT | -2 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
1212 | 1632 | 45 | 3H-SPIPERONE | -18 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
204 | 1632 | 45 | 3H-SPIPERONE | -18 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
3372 | 1632 | 45 | 3H-SPIPERONE | -18 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL726 | 1632 | 45 | 3H-SPIPERONE | -18 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00623 | 1632 | 45 | 3H-SPIPERONE | -18 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
119570 | 3110 | 90 | None | -10 | 40 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
2233 | 3110 | 90 | None | -10 | 40 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
953 | 3110 | 90 | None | -10 | 40 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
CHEMBL301265 | 3110 | 90 | None | -10 | 40 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
DB00413 | 3110 | 90 | None | -10 | 40 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
1238 | 201484 | 21 | None | -2 | 16 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
CHEMBL64249 | 201484 | 21 | None | -2 | 16 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
2726 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-SPIPERONE | -8 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
135398737 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
38 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
722 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
CHEMBL42 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
DB00363 | 944 | 89 | 3H-SPIPERONE | -7 | 91 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
135398745 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
47 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
CHEMBL715 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
DB00334 | 2869 | 108 | 3H-SPIPERONE | -7 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
2726 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
621 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
83 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
CHEMBL71 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
DB00477 | 906 | 64 | 3H-SPIPERONE | -10 | 72 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
191 | 399 | 92 | 3H-SPIPERONE | -67 | 28 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
201 | 399 | 92 | 3H-SPIPERONE | -67 | 28 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
2170 | 399 | 92 | 3H-SPIPERONE | -67 | 28 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
CHEMBL1113 | 399 | 92 | 3H-SPIPERONE | -67 | 28 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
DB00543 | 399 | 92 | 3H-SPIPERONE | -67 | 28 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
None | 214684 | 0 | 3H-SPIPERONE | -467 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 160 | 1 | 0 | 2 | 2.6 | CC(=O)C1=CC2=CC=CC=C2O1 | None | ||
1577 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
164512405 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
2537 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5355 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
5501 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
643497 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
688272 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
958 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
960 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL196677 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL26 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
CHEMBL267044 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB00391 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
DB16021 | 3647 | 104 | 3H-SPIPERONE | -8 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
202478 | 202981 | 15 | 3H-NMSP | -7 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | ||
CHEMBL7393 | 202981 | 15 | 3H-NMSP | -7 | 25 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | ||
115368 | 3007 | 0 | None | 1 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | 9577836 | ||
2112 | 3007 | 0 | None | 1 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | 9577836 | ||
7556 | 3007 | 0 | None | 1 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | 9577836 | ||
CHEMBL1472975 | 3007 | 0 | None | 1 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | 9577836 | ||
DB08922 | 3007 | 0 | None | 1 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 426 | 6 | 0 | 6 | 3.4 | O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 | 9577836 | ||
16363 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 9577836 | ||
312 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 9577836 | ||
9215 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 9577836 | ||
CHEMBL297302 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 9577836 | ||
DB12867 | 589 | 48 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 381 | 6 | 1 | 4 | 3.8 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 9577836 | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
3033769 | 3229 | 54 | None | -288 | 18 | Rat | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10617689 | ||
3299 | 3229 | 54 | None | -288 | 18 | Rat | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10617689 | ||
94 | 3229 | 54 | None | -288 | 18 | Rat | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10617689 | ||
CHEMBL8809 | 3229 | 54 | None | -288 | 18 | Rat | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10617689 | ||
DB12518 | 3229 | 54 | None | -288 | 18 | Rat | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | 10617689 | ||
16094676 | 230 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 17149874 | ||
8439 | 230 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 17149874 | ||
CHEMBL219182 | 230 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 325 | 4 | 1 | 3 | 2.2 | Cc1cccc(c1)C(=O)NCN1CCC(CC1)c1cccc[n+]1[O-] | 17149874 | ||
2274 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
4917 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
7279 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
CHEMBL728 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
DB00433 | 3124 | 53 | None | -56 | 32 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
31101 | 720 | 39 | None | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | ||
35 | 720 | 39 | None | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | ||
403 | 720 | 39 | None | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | ||
CHEMBL493 | 720 | 39 | None | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | ||
DB01200 | 720 | 39 | None | -186 | 35 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
1577 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
164512405 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
2537 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
5355 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
5501 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
643497 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
688272 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
958 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
960 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
CHEMBL196677 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
CHEMBL26 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
CHEMBL267044 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
DB00391 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8301592 | ||
DB16021 | 3647 | 104 | None | -8 | 25 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | 8967990 | ||
2407 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 8863800 | ||
59227 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 8863800 | ||
941 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 8863800 | ||
CHEMBL1303 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 8863800 | ||
DB05271 | 3320 | 73 | None | -30 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 8863800 | ||
214 | 3799 | 52 | None | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 9015795 | ||
2740 | 3799 | 52 | None | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 9015795 | ||
5566 | 3799 | 52 | None | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 9015795 | ||
66064 | 3799 | 52 | None | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 9015795 | ||
CHEMBL422 | 3799 | 52 | None | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 9015795 | ||
DB00831 | 3799 | 52 | None | -33 | 29 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 9015795 | ||
103 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
2875 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
5736 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
CHEMBL285802 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
DB09225 | 4089 | 56 | None | -17 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
72737723 | 2541 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 25221667 | ||
8440 | 2541 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 25221667 | ||
CHEMBL3335556 | 2541 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 315 | 5 | 0 | 2 | 4.2 | Clc1ccc(cc1)CN1CCO[C@@H](C1)CCc1ccccc1 | 25221667 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 12388666 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 1840645 | ||
2 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 8967990 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 12388666 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 1840645 | ||
54562 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 8967990 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 12388666 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 1840645 | ||
CHEMBL240773 | 3210 | 19 | None | -2 | 28 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | 8967990 | ||
681 | 1437 | 65 | None | -2 | 38 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1840645 | ||
940 | 1437 | 65 | None | -2 | 38 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1840645 | ||
947 | 1437 | 65 | None | -2 | 38 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1840645 | ||
CHEMBL59 | 1437 | 65 | None | -2 | 38 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1840645 | ||
DB00988 | 1437 | 65 | None | -2 | 38 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1840645 | ||
3251 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 21520940 | ||
5684 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 21520940 | ||
80 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 21520940 | ||
CHEMBL31354 | 4009 | 50 | None | -43 | 12 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 422 | 7 | 0 | 5 | 3.8 | COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 | 21520940 | ||
10425450 | 199 | 23 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 16153699 | ||
10425450 | 199 | 23 | None | 1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 16153699 | ||
3301 | 199 | 23 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 16153699 | ||
3301 | 199 | 23 | None | 1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 16153699 | ||
CHEMBL375596 | 199 | 23 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 16153699 | ||
CHEMBL375596 | 199 | 23 | None | 1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 309 | 4 | 1 | 3 | 3.2 | O=C(Nc1cccc(c1)C)CN1CCC(CC1)c1ccccn1 | 16153699 | ||
1613 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 9015795 | ||
205 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 9015795 | ||
3964 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 9015795 | ||
CHEMBL831 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 9015795 | ||
DB00408 | 2316 | 44 | None | -2 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 9015795 | ||
228 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | ||
33 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | ||
6005 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | ||
CHEMBL53 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | ||
DB00714 | 441 | 26 | None | -1 | 24 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | ||
2435 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 16135699 | ||
2435 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9015795 | ||
2435 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9577836 | ||
60149 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 16135699 | ||
60149 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9015795 | ||
60149 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9577836 | ||
98 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 16135699 | ||
98 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9015795 | ||
98 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9577836 | ||
CHEMBL12713 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 16135699 | ||
CHEMBL12713 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9015795 | ||
CHEMBL12713 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9577836 | ||
DB06144 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 16135699 | ||
DB06144 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9015795 | ||
DB06144 | 3533 | 78 | None | -10 | 48 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 9577836 | ||
133008 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 8642551 | ||
3302 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 8642551 | ||
CHEMBL444309 | 2211 | 16 | None | 204 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 380 | 5 | 0 | 3 | 5.7 | Clc1ccc(cc1)c1onc(c1C)C1CCN(CC1)CCc1ccccc1 | 8642551 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 18308814 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 7862709 | ||
1353 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8102973 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 18308814 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 7862709 | ||
3559 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8102973 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 18308814 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 7862709 | ||
86 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8102973 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 18308814 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 7862709 | ||
CHEMBL54 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8102973 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 18308814 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 7862709 | ||
DB00502 | 1880 | 85 | None | -3 | 85 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8102973 | ||
3645619 | 2985 | 13 | None | 4 | 9 | Rat | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 15448188 | ||
975 | 2985 | 13 | None | 4 | 9 | Rat | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 15448188 | ||
CHEMBL45244 | 2985 | 13 | None | 4 | 9 | Rat | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 334 | 4 | 1 | 4 | 2.4 | N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C | 15448188 | ||
11301655 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 15992586 | ||
8441 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 15992586 | ||
CHEMBL127257 | 198 | 31 | None | 245 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 320 | 3 | 1 | 3 | 3.5 | Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2 | 15992586 | ||
133079 | 3581 | 33 | None | 1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 9098699 | ||
980 | 3581 | 33 | None | 1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 9098699 | ||
CHEMBL69759 | 3581 | 33 | None | 1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 9098699 | ||
5615 | 3836 | 4 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 9098699 | ||
5781 | 3836 | 4 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 9098699 | ||
CHEMBL1179189 | 3836 | 4 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 339 | 6 | 0 | 4 | 4.0 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccccc1)C)C | 9098699 | ||
3303 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 8642550 | ||
5311200 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 8642550 | ||
CHEMBL267014 | 2213 | 41 | None | 1 | 15 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 326 | 3 | 1 | 3 | 3.5 | Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 8642550 | ||
179 | 396 | 107 | None | -50 | 50 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
2159 | 396 | 107 | None | -50 | 50 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
963 | 396 | 107 | None | -50 | 50 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
CHEMBL243712 | 396 | 107 | None | -50 | 50 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
DB06288 | 396 | 107 | None | -50 | 50 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
243 | 3153 | 85 | None | -12 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
3052762 | 3153 | 85 | None | -12 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
3502 | 3153 | 85 | None | -12 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
CHEMBL117287 | 3153 | 85 | None | -12 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
DB06480 | 3153 | 85 | None | -12 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
213 | 3792 | 50 | None | -3 | 43 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
2717 | 3792 | 50 | None | -3 | 43 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
5533 | 3792 | 50 | None | -3 | 43 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
CHEMBL621 | 3792 | 50 | None | -3 | 43 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
DB00656 | 3792 | 50 | None | -3 | 43 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
2342 | 592 | 0 | None | -1 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 404 | 6 | 0 | 6 | 2.4 | CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC | None | ||
331 | 592 | 0 | None | -1 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 404 | 6 | 0 | 6 | 2.4 | CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC | None | ||
7124 | 592 | 0 | None | -1 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 404 | 6 | 0 | 6 | 2.4 | CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC | None | ||
CHEMBL1201250 | 592 | 0 | None | -1 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 404 | 6 | 0 | 6 | 2.4 | CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC | None | ||
DB00767 | 592 | 0 | None | -1 | 6 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 404 | 6 | 0 | 6 | 2.4 | CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC | None | ||
5281878 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
5281881 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
948 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
968 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL42055 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
CHEMBL54661 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
DB00875 | 1630 | 33 | None | -14 | 16 | Human | 8.1 | pKi | None | 8.1 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
11976 | 907 | 54 | None | -2 | 23 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
667467 | 907 | 54 | None | -2 | 23 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
CHEMBL908 | 907 | 54 | None | -2 | 23 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
DB01239 | 907 | 54 | None | -2 | 23 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
5567 | 42556 | 24 | None | -11 | 7 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 409 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 | None | ||
CHEMBL15023 | 42556 | 24 | None | -11 | 7 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 409 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 | None | ||
6603897 | 2216 | 19 | None | 5 | 2 | Rat | 10.0 | pKi | None | 10 | Binding | Guide to Pharmacology | 418 | 3 | 1 | 3 | 3.5 | Ic1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10617689 | ||
978 | 2216 | 19 | None | 5 | 2 | Rat | 10.0 | pKi | None | 10 | Binding | Guide to Pharmacology | 418 | 3 | 1 | 3 | 3.5 | Ic1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10617689 | ||
CHEMBL60518 | 2216 | 19 | None | 5 | 2 | Rat | 10.0 | pKi | None | 10 | Binding | Guide to Pharmacology | 418 | 3 | 1 | 3 | 3.5 | Ic1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2 | 10617689 | ||
37459 | 735 | 10 | None | -123 | 24 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | 8967990 | ||
62 | 735 | 10 | None | -123 | 24 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | 8967990 | ||
CHEMBL8514 | 735 | 10 | None | -123 | 24 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | 8967990 | ||
3408722 | 2674 | 41 | None | -1318 | 5 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 365 | 7 | 1 | 4 | 3.7 | CCCCN1CCCC1CNC(=O)c1cc(C#N)c2c(c1OC)cccc2 | 10617689 | ||
44 | 2674 | 41 | None | -1318 | 5 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 365 | 7 | 1 | 4 | 3.7 | CCCCN1CCCC1CNC(=O)c1cc(C#N)c2c(c1OC)cccc2 | 10617689 | ||
CHEMBL286252 | 2674 | 41 | None | -1318 | 5 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 365 | 7 | 1 | 4 | 3.7 | CCCCN1CCCC1CNC(=O)c1cc(C#N)c2c(c1OC)cccc2 | 10617689 | ||
1153 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
12668023 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
30026874 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
30026875 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
3341 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
6603851 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
933 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
939 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
985 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
CHEMBL1160786 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
CHEMBL1161520 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
CHEMBL588 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
DB00800 | 1598 | 53 | None | -16 | 10 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1840645 | ||
2202 | 3083 | 91 | None | -2 | 21 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | 12388666 | ||
4850 | 3083 | 91 | None | -2 | 21 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | 12388666 | ||
49 | 3083 | 91 | None | -2 | 21 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | 12388666 | ||
CHEMBL1371770 | 3083 | 91 | None | -2 | 21 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | 12388666 | ||
DB12478 | 3083 | 91 | None | -2 | 21 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | 12388666 | ||
57267 | 1563 | 11 | None | -416 | 4 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 7475902 | ||
966 | 1563 | 11 | None | -416 | 4 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 7475902 | ||
CHEMBL8946 | 1563 | 11 | None | -416 | 4 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 7475902 | ||
DB15492 | 1563 | 11 | None | -416 | 4 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 340 | 6 | 2 | 4 | 2.8 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl | 7475902 | ||
2105 | 3005 | 34 | None | -48 | 33 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | ||
47811 | 3005 | 34 | None | -48 | 33 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | ||
48 | 3005 | 34 | None | -48 | 33 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | ||
CHEMBL531 | 3005 | 34 | None | -48 | 33 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | ||
DB01186 | 3005 | 34 | None | -48 | 33 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | ||
242 | 467 | 117 | None | -87 | 51 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10617689 | ||
34 | 467 | 117 | None | -87 | 51 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10617689 | ||
60795 | 467 | 117 | None | -87 | 51 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10617689 | ||
CHEMBL1112 | 467 | 117 | None | -87 | 51 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10617689 | ||
DB01238 | 467 | 117 | None | -87 | 51 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10617689 | ||
37 | 766 | 56 | None | -7 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | ||
460 | 766 | 56 | None | -7 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | ||
54746 | 766 | 56 | None | -7 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | ||
CHEMBL1201087 | 766 | 56 | None | -7 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | ||
DB00248 | 766 | 56 | None | -7 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | ||
681 | 1437 | 65 | None | -7 | 38 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10617689 | ||
940 | 1437 | 65 | None | -7 | 38 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10617689 | ||
947 | 1437 | 65 | None | -7 | 38 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10617689 | ||
CHEMBL59 | 1437 | 65 | None | -7 | 38 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10617689 | ||
DB00988 | 1437 | 65 | None | -7 | 38 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10617689 | ||
135398737 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8102973 | ||
38 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8102973 | ||
722 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8102973 | ||
CHEMBL42 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8102973 | ||
DB00363 | 944 | 89 | None | -13 | 91 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8102973 | ||
2726 | 906 | 64 | None | -8 | 72 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 8102973 | ||
621 | 906 | 64 | None | -8 | 72 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 8102973 | ||
83 | 906 | 64 | None | -8 | 72 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 8102973 | ||
CHEMBL71 | 906 | 64 | None | -8 | 72 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 8102973 | ||
DB00477 | 906 | 64 | None | -8 | 72 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 8102973 | ||
11429930 | 3289 | 0 | None | - | 1 | Rat | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 415 | 8 | 3 | 7 | 1.9 | COc1cc(ccc1O)N1CCN(CC1)CC(COc1ccccc1NC(=O)C)O | 15448188 | ||
982 | 3289 | 0 | None | - | 1 | Rat | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 415 | 8 | 3 | 7 | 1.9 | COc1cc(ccc1O)N1CCN(CC1)CC(COc1ccccc1NC(=O)C)O | 15448188 | ||
2601 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
443951 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
56 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
CHEMBL73151 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
DB13399 | 3721 | 30 | None | -7 | 21 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
219050 | 3321 | 21 | None | -58 | 21 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 12388666 | ||
52 | 3321 | 21 | None | -58 | 21 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 12388666 | ||
CHEMBL431367 | 3321 | 21 | None | -58 | 21 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | 12388666 | ||
1588 | 2294 | 24 | None | -23 | 43 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
28864 | 2294 | 24 | None | -23 | 43 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
43 | 2294 | 24 | None | -23 | 43 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
CHEMBL157138 | 2294 | 24 | None | -23 | 43 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
DB00589 | 2294 | 24 | None | -23 | 43 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | ||
133079 | 3581 | 33 | None | -1 | 4 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 15448188 | ||
980 | 3581 | 33 | None | -1 | 4 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 15448188 | ||
CHEMBL69759 | 3581 | 33 | None | -1 | 4 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 401 | 5 | 1 | 5 | 2.2 | NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2 | 15448188 | ||
10336538 | 1595 | 44 | None | 3 | 8 | Rat | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 15448188 | ||
974 | 1595 | 44 | None | 3 | 8 | Rat | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 15448188 | ||
CHEMBL310843 | 1595 | 44 | None | 3 | 8 | Rat | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 326 | 3 | 0 | 4 | 3.3 | Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2 | 15448188 | ||
2470 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7475902 | ||
3300 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7475902 | ||
5265 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7475902 | ||
99 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7475902 | ||
CHEMBL267930 | 3596 | 46 | None | -20 | 59 | Human | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 7475902 | ||
973 | 1154 | 33 | None | 9 | 6 | Rat | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 15448188 | ||
9796720 | 1154 | 33 | None | 9 | 6 | Rat | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 15448188 | ||
CHEMBL77395 | 1154 | 33 | None | 9 | 6 | Rat | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 310 | 3 | 1 | 3 | 3.0 | Fc1ccc2c(c1)cc([nH]2)CN1CCN(CC1)c1ccccn1 | 15448188 | ||
977 | 1155 | 3 | None | 10 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(cc1)OC[C@@H]1CC[C@@H]2N(C1)CCN(C2)c1ncc(cn1)F | 15448188 | ||
9820261 | 1155 | 3 | None | 10 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(cc1)OC[C@@H]1CC[C@@H]2N(C1)CCN(C2)c1ncc(cn1)F | 15448188 | ||
CHEMBL66227 | 1155 | 3 | None | 10 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 360 | 4 | 0 | 5 | 2.7 | Fc1ccc(cc1)OC[C@@H]1CC[C@@H]2N(C1)CCN(C2)c1ncc(cn1)F | 15448188 | ||
188942 | 2778 | 38 | None | 12 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 15448188 | ||
3297 | 2778 | 38 | None | 12 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 15448188 | ||
979 | 2778 | 38 | None | 12 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 15448188 | ||
CHEMBL103772 | 2778 | 38 | None | 12 | 4 | Rat | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 320 | 4 | 1 | 5 | 2.2 | c1ccc(cc1)c1ncc([nH]1)CN1CCN(CC1)c1ncccn1 | 15448188 | ||
5041 | 3242 | 5 | None | 1 | 5 | Rat | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 15448188 | ||
981 | 3242 | 5 | None | 1 | 5 | Rat | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 15448188 | ||
CHEMBL4096543 | 3242 | 5 | None | 1 | 5 | Rat | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 465 | 6 | 0 | 4 | 4.6 | CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C | 15448188 |