Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 10689833 | 12657 | 0 | None | -4 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 359 | 8 | 1 | 2 | 4.8 | c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL11879 | 12657 | 0 | None | -4 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 359 | 8 | 1 | 2 | 4.8 | c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 11791817 | 97851 | 0 | None | -1 | 2 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL274831 | 97851 | 0 | None | -1 | 2 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 10403687 | 2475 | 2 | None | -1 | 2 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | -1 | 2 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | -1 | 2 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1269 | 121 | 33 | None | -354 | 6 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 125 | 2 | 2 | 2 | 0.2 | Cc1c(CCN)nc[nH]1 | 10.1021/jm900526h | ||
| 37463 | 121 | 33 | None | -354 | 6 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 125 | 2 | 2 | 2 | 0.2 | Cc1c(CCN)nc[nH]1 | 10.1021/jm900526h | ||
| CHEMBL275443 | 121 | 33 | None | -354 | 6 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 125 | 2 | 2 | 2 | 0.2 | Cc1c(CCN)nc[nH]1 | 10.1021/jm900526h | ||
| 126688 | 400 | 28 | None | -57 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 157 | 2 | 2 | 4 | 0.5 | NCCc1sc(nc1C)N | 10.1016/j.bmcl.2010.10.041 | ||
| 4025 | 400 | 28 | None | -57 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 157 | 2 | 2 | 4 | 0.5 | NCCc1sc(nc1C)N | 10.1016/j.bmcl.2010.10.041 | ||
| CHEMBL293762 | 400 | 28 | None | -57 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 157 | 2 | 2 | 4 | 0.5 | NCCc1sc(nc1C)N | 10.1016/j.bmcl.2010.10.041 | ||
| 11617365 | 73927 | 0 | None | - | 1 | Guinea pig | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 319 | 7 | 2 | 3 | 3.3 | NCCc1c[nH]c(C(=O)CC(c2ccccc2)c2ccccc2)n1 | 10.1016/j.bmcl.2005.10.030 | ||
| CHEMBL202371 | 73927 | 0 | None | - | 1 | Guinea pig | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 319 | 7 | 2 | 3 | 3.3 | NCCc1c[nH]c(C(=O)CC(c2ccccc2)c2ccccc2)n1 | 10.1016/j.bmcl.2005.10.030 | ||
| 10042467 | 1398 | 1 | None | 1 | 2 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | 1 | 2 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | 1 | 2 | Rat | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 10447834 | 1902 | 4 | None | 2 | 3 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | 2 | 3 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | 2 | 3 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm900526h | ||
| 1247 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm900526h | ||
| 1375 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm900526h | ||
| 774 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm900526h | ||
| CHEMBL90 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm900526h | ||
| DB05381 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm900526h | ||
| 10447834 | 1902 | 4 | None | 2 | 3 | Guinea pig | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | 2 | 3 | Guinea pig | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | 2 | 3 | Guinea pig | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2005.10.030 | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2005.10.030 | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2005.10.030 | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2005.10.030 | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2005.10.030 | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2005.10.030 | ||
| 1194 | 46 | 3 | None | 50 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/j.bmcl.2010.10.041 | ||
| 23786499 | 46 | 3 | None | 50 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/j.bmcl.2010.10.041 | ||
| CHEMBL26116 | 46 | 3 | None | 50 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/j.bmcl.2010.10.041 | ||
| 1204 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| 1247 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| 1375 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| 774 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| CHEMBL90 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| DB05381 | 1901 | 114 | None | -4 | 10 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| 11791817 | 97851 | 0 | None | -1 | 2 | Guinea pig | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL274831 | 97851 | 0 | None | -1 | 2 | Guinea pig | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 5310982 | 93179 | 4 | None | 3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2010.10.041 | ||
| CHEMBL24665 | 93179 | 4 | None | 3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2010.10.041 | ||
| 44267376 | 10125 | 1 | None | - | 1 | Guinea pig | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 277 | 5 | 2 | 2 | 3.1 | NCCc1c[nH]c(C(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL11603 | 10125 | 1 | None | - | 1 | Guinea pig | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 277 | 5 | 2 | 2 | 3.1 | NCCc1c[nH]c(C(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 10689833 | 12657 | 0 | None | 4 | 2 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 359 | 8 | 1 | 2 | 4.8 | c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL11879 | 12657 | 0 | None | 4 | 2 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 359 | 8 | 1 | 2 | 4.8 | c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 10688111 | 9945 | 0 | None | 2 | 2 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.3 | CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL11515 | 9945 | 0 | None | 2 | 2 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.3 | CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 10447834 | 1902 | 4 | None | 2 | 3 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | 2 | 3 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | 2 | 3 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 11791817 | 97851 | 0 | None | 1 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL274831 | 97851 | 0 | None | 1 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 10685002 | 10065 | 0 | None | - | 1 | Guinea pig | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 291 | 6 | 2 | 2 | 3.3 | NCCc1c[nH]c(CC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL11584 | 10065 | 0 | None | - | 1 | Guinea pig | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 291 | 6 | 2 | 2 | 3.3 | NCCc1c[nH]c(CC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -4 | 10 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0603318 | ||
| 1247 | 1901 | 114 | None | -4 | 10 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0603318 | ||
| 1375 | 1901 | 114 | None | -4 | 10 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0603318 | ||
| 774 | 1901 | 114 | None | -4 | 10 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0603318 | ||
| CHEMBL90 | 1901 | 114 | None | -4 | 10 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0603318 | ||
| DB05381 | 1901 | 114 | None | -4 | 10 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0603318 | ||
| 10403687 | 2475 | 2 | None | 1 | 2 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | 1 | 2 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | 1 | 2 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 10403687 | 2475 | 2 | None | 1 | 2 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | 1 | 2 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | 1 | 2 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 11846300 | 79856 | 3 | None | 2 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1021/jm051008s | ||
| CHEMBL213912 | 79856 | 3 | None | 2 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1021/jm051008s | ||
| 10688111 | 9945 | 0 | None | -2 | 2 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.3 | CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL11515 | 9945 | 0 | None | -2 | 2 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.3 | CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 10403687 | 2475 | 2 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 91613 | 17804 | 31 | None | 5 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 125 | 2 | 2 | 2 | 0.2 | Cc1ncc(CCN)[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| CHEMBL12620 | 17804 | 31 | None | 5 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 125 | 2 | 2 | 2 | 0.2 | Cc1ncc(CCN)[nH]1 | 10.1016/j.bmcl.2010.10.041 | ||
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 10447834 | 1902 | 4 | None | -2 | 3 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | -2 | 3 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | -2 | 3 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 11976 | 907 | 54 | None | -9 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| 667467 | 907 | 54 | None | -9 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| CHEMBL908 | 907 | 54 | None | -9 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| DB01239 | 907 | 54 | None | -9 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| 13623342 | 64016 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 286 | 5 | 0 | 5 | 1.9 | C=COCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18123 | 64016 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 286 | 5 | 0 | 5 | 1.9 | C=COCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 3071006 | 64684 | 1 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 314 | 6 | 0 | 5 | 2.4 | C=CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18233 | 64684 | 1 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 314 | 6 | 0 | 5 | 2.4 | C=CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623366 | 66381 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 330 | 7 | 0 | 5 | 3.0 | CCCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18561 | 66381 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 330 | 7 | 0 | 5 | 3.0 | CCCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 3071004 | 167198 | 5 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 288 | 5 | 0 | 5 | 1.8 | CCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL430338 | 167198 | 5 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 288 | 5 | 0 | 5 | 1.8 | CCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 1227 | 2454 | 35 | None | 2 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 2331 | 2454 | 35 | None | 2 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 3957 | 2454 | 35 | None | 2 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 4992 | 2454 | 35 | None | 2 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| DB06691 | 2454 | 35 | None | 2 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 44458944 | 98603 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 337 | 3 | 0 | 1 | 5.5 | c1ccc(CN2CCC3C(=C(c4ccccc4)c4ccccc43)C2)cc1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL280432 | 98603 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 337 | 3 | 0 | 1 | 5.5 | c1ccc(CN2CCC3C(=C(c4ccccc4)c4ccccc43)C2)cc1 | 10.1016/s0960-894x(00)00199-2 | ||
| 44224259 | 62394 | 4 | None | 30 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783959 | 62394 | 4 | None | 30 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 3529324 | 206613 | 1 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 306 | 6 | 0 | 3 | 3.3 | CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202934 | 206613 | 1 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 306 | 6 | 0 | 3 | 3.3 | CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL99417 | 206613 | 1 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 306 | 6 | 0 | 3 | 3.3 | CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| 44126329 | 62389 | 6 | None | -2 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783954 | 62389 | 6 | None | -2 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 153996 | 112171 | 2 | None | -57 | 6 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330366 | 112171 | 2 | None | -57 | 6 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL539021 | 112171 | 2 | None | -57 | 6 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 44126270 | 197472 | 6 | None | 10 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 320 | 4 | 0 | 3 | 3.9 | COc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589389 | 197472 | 6 | None | 10 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 320 | 4 | 0 | 3 | 3.9 | COc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 3071008 | 98295 | 2 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 274 | 5 | 1 | 5 | 1.5 | CCOCCn1c(N2CCNCC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL278053 | 98295 | 2 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 274 | 5 | 1 | 5 | 1.5 | CCOCCn1c(N2CCNCC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 54585846 | 62398 | 4 | None | 38 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 3.7 | Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783963 | 62398 | 4 | None | 38 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 3.7 | Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1 | 10.1016/j.bmcl.2009.04.128 | ||
| 44126269 | 199799 | 4 | None | 2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 318 | 3 | 0 | 2 | 4.5 | Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL605081 | 199799 | 4 | None | 2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 318 | 3 | 0 | 2 | 4.5 | Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| 1210 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 1213 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 2725 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 33036 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 4411 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 616 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 6976 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 716121 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 90475904 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| CHEMBL1201353 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| CHEMBL1554789 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| CHEMBL505 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| DB01114 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| DB13679 | 905 | 45 | None | 2 | 17 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00157a010 | ||
| 3071000 | 98203 | 1 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 298 | 5 | 0 | 5 | 1.4 | C#CCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL277311 | 98203 | 1 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 298 | 5 | 0 | 5 | 1.4 | C#CCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 54582939 | 62392 | 6 | None | 8 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 369 | 3 | 0 | 3 | 4.0 | CN1CCc2c(c3cc(Br)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783957 | 62392 | 6 | None | 8 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 369 | 3 | 0 | 3 | 4.0 | CN1CCc2c(c3cc(Br)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54579957 | 62399 | 4 | None | 36 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783964 | 62399 | 4 | None | 36 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54580942 | 62402 | 9 | None | 13 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783967 | 62402 | 9 | None | 13 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 4440380 | 4190 | 3 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL100487 | 4190 | 3 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202938 | 4190 | 3 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| 10234086 | 111144 | 0 | None | -6 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL328511 | 111144 | 0 | None | -6 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| 10190770 | 206275 | 0 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330430 | 206275 | 0 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL97357 | 206275 | 0 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 54585848 | 62405 | 6 | None | 5 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 316 | 3 | 0 | 4 | 3.1 | CN1CCc2c(c3cc(C#N)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783971 | 62405 | 6 | None | 5 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 316 | 3 | 0 | 4 | 3.1 | CN1CCc2c(c3cc(C#N)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623354 | 98523 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 4 | 0 | 5 | 1.4 | COCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL279872 | 98523 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 274 | 4 | 0 | 5 | 1.4 | COCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 46225000 | 197436 | 4 | None | 9 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 308 | 3 | 0 | 2 | 4.0 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589148 | 197436 | 4 | None | 9 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 308 | 3 | 0 | 2 | 4.0 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 13623347 | 60729 | 0 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 286 | 4 | 0 | 4 | 3.1 | CCCC(C)n1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17635 | 60729 | 0 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 286 | 4 | 0 | 4 | 3.1 | CCCC(C)n1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623346 | 98488 | 0 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 286 | 4 | 0 | 4 | 2.8 | CC(C)CCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL279621 | 98488 | 0 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 286 | 4 | 0 | 4 | 2.8 | CC(C)CCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 42631003 | 197937 | 10 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL592752 | 197937 | 10 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 13623371 | 64874 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 378 | 7 | 0 | 5 | 3.8 | CCOCCn1c(N2CCCN(Cc3ccccc3)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18255 | 64874 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 378 | 7 | 0 | 5 | 3.8 | CCOCCn1c(N2CCCN(Cc3ccccc3)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623360 | 98352 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 330 | 8 | 0 | 5 | 3.0 | CCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL278504 | 98352 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 330 | 8 | 0 | 5 | 3.0 | CCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 13623338 | 63018 | 0 | None | - | 1 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 314 | 7 | 0 | 4 | 3.8 | CCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17946 | 63018 | 0 | None | - | 1 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 314 | 7 | 0 | 4 | 3.8 | CCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 46224879 | 199862 | 3 | None | -1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 302 | 2 | 0 | 2 | 4.6 | Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL605405 | 199862 | 3 | None | -1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 302 | 2 | 0 | 2 | 4.6 | Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 9832306 | 112227 | 0 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330367 | 112227 | 0 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330462 | 112227 | 0 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10097-X | ||
| 197033 | 197473 | 58 | None | 1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589390 | 197473 | 58 | None | 1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 1227 | 2454 | 35 | None | 2 | 10 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 2331 | 2454 | 35 | None | 2 | 10 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 3957 | 2454 | 35 | None | 2 | 10 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 4992 | 2454 | 35 | None | 2 | 10 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 10 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| DB06691 | 2454 | 35 | None | 2 | 10 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1038/nchembio714 | ||
| 197033 | 197473 | 58 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589390 | 197473 | 58 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 197033 | 197473 | 58 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL589390 | 197473 | 58 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54582940 | 62393 | 4 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 359 | 3 | 0 | 3 | 4.3 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783958 | 62393 | 4 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 359 | 3 | 0 | 3 | 4.3 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623367 | 60060 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 316 | 6 | 0 | 5 | 2.6 | CCOCCn1c(N2CCCN(CC)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17474 | 60060 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 316 | 6 | 0 | 5 | 2.6 | CCOCCn1c(N2CCCN(CC)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623359 | 64231 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 316 | 7 | 0 | 5 | 2.6 | CCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL18151 | 64231 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 316 | 7 | 0 | 5 | 2.6 | CCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 3071032 | 64708 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 316 | 6 | 0 | 5 | 2.6 | CCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18234 | 64708 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 316 | 6 | 0 | 5 | 2.6 | CCCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 621659 | 62400 | 10 | None | -2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783965 | 62400 | 10 | None | -2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 197033 | 197473 | 58 | None | 1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL589390 | 197473 | 58 | None | 1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 3 | 3.9 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 44458903 | 90215 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 275 | 2 | 0 | 1 | 4.3 | CCN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL23897 | 90215 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 275 | 2 | 0 | 1 | 4.3 | CCN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1016/s0960-894x(00)00199-2 | ||
| 2773189 | 59427 | 3 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 306 | 3 | 0 | 4 | 2.8 | CN1CCN(c2nc3ccccc3n2Cc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL17246 | 59427 | 3 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 306 | 3 | 0 | 4 | 2.8 | CN1CCN(c2nc3ccccc3n2Cc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| 3071002 | 62688 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 300 | 6 | 0 | 5 | 2.0 | C=CCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17876 | 62688 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 300 | 6 | 0 | 5 | 2.0 | C=CCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 145990794 | 166247 | 0 | None | -28 | 6 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 437 | 6 | 0 | 5 | 3.8 | O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2017.12.099 | ||
| CHEMBL4284346 | 166247 | 0 | None | -28 | 6 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 437 | 6 | 0 | 5 | 3.8 | O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2017.12.099 | ||
| 4919 | 204511 | 21 | None | -95 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 287 | 5 | 1 | 2 | 3.9 | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 | 10.1021/jm300671m | ||
| CHEMBL86715 | 204511 | 21 | None | -95 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 287 | 5 | 1 | 2 | 3.9 | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 | 10.1021/jm300671m | ||
| 13623352 | 59691 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 288 | 5 | 0 | 5 | 2.2 | CCCOCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17349 | 59691 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 288 | 5 | 0 | 5 | 2.2 | CCCOCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 3071010 | 63588 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 302 | 6 | 0 | 5 | 2.2 | CCOCCn1c(N2CCN(CC)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18060 | 63588 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 302 | 6 | 0 | 5 | 2.2 | CCOCCn1c(N2CCN(CC)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 46224877 | 199017 | 5 | None | 74 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 288 | 2 | 0 | 2 | 4.3 | CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL599913 | 199017 | 5 | None | 74 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 288 | 2 | 0 | 2 | 4.3 | CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 54586812 | 62388 | 4 | None | 12 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783953 | 62388 | 4 | None | 12 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623336 | 60173 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 286 | 5 | 0 | 4 | 3.0 | CCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17555 | 60173 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 286 | 5 | 0 | 4 | 3.0 | CCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623350 | 62782 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 304 | 5 | 0 | 5 | 2.5 | CCSCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17893 | 62782 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 304 | 5 | 0 | 5 | 2.5 | CCSCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 145983928 | 165859 | 0 | None | -53 | 6 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 435 | 6 | 0 | 5 | 3.6 | O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2017.12.099 | ||
| CHEMBL4277101 | 165859 | 0 | None | -53 | 6 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 435 | 6 | 0 | 5 | 3.6 | O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2017.12.099 | ||
| 3071014 | 97634 | 1 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 302 | 6 | 0 | 5 | 2.2 | CCCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL273320 | 97634 | 1 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 302 | 6 | 0 | 5 | 2.2 | CCCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 126624 | 206549 | 9 | None | - | 1 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 264 | 5 | 0 | 3 | 2.2 | CN(C)CCCN1C(=O)CSC1c1ccccc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202936 | 206549 | 9 | None | - | 1 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 264 | 5 | 0 | 3 | 2.2 | CN(C)CCCN1C(=O)CSC1c1ccccc1 | 10.1021/jm00093a025 | ||
| CHEMBL98989 | 206549 | 9 | None | - | 1 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 264 | 5 | 0 | 3 | 2.2 | CN(C)CCCN1C(=O)CSC1c1ccccc1 | 10.1021/jm00093a025 | ||
| 10123138 | 108039 | 0 | None | -1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL317524 | 108039 | 0 | None | -1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL320002 | 108039 | 0 | None | -1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 2861271 | 4189 | 8 | None | - | 1 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL100486 | 4189 | 8 | None | - | 1 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1 | 10.1021/jm00093a025 | ||
| 46224878 | 197788 | 0 | None | 2 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 290 | 2 | 0 | 2 | 4.0 | CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL591568 | 197788 | 0 | None | 2 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 290 | 2 | 0 | 2 | 4.0 | CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1 | 10.1016/j.bmcl.2009.11.037 | ||
| 54585847 | 62403 | 6 | None | 29 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 359 | 3 | 0 | 3 | 4.3 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783968 | 62403 | 6 | None | 29 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 359 | 3 | 0 | 3 | 4.3 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 198539 | 98774 | 3 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 259 | 1 | 0 | 1 | 3.8 | CN1CC=C2C(=C(c3ccccc3)c3ccccc32)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL281638 | 98774 | 3 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 259 | 1 | 0 | 1 | 3.8 | CN1CC=C2C(=C(c3ccccc3)c3ccccc32)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| 2860026 | 107890 | 6 | None | - | 1 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1 | 10.1021/jm00093a025 | ||
| CHEMBL319829 | 107890 | 6 | None | - | 1 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1 | 10.1021/jm00093a025 | ||
| 7430452 | 99019 | 2 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.1 | CCN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL283169 | 99019 | 2 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.1 | CCN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| 2861590 | 106776 | 7 | None | - | 1 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202937 | 106776 | 7 | None | - | 1 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL316951 | 106776 | 7 | None | - | 1 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1 | 10.1021/jm00093a025 | ||
| 10212223 | 206399 | 0 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL431458 | 206399 | 0 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL98079 | 206399 | 0 | None | -2 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 10190056 | 110950 | 0 | None | 1 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL327497 | 110950 | 0 | None | 1 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
| 13623341 | 61791 | 0 | None | - | 1 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 320 | 4 | 0 | 4 | 3.0 | CN1CCN(c2nc3ccccc3n2CCc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL17763 | 61791 | 0 | None | - | 1 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 320 | 4 | 0 | 4 | 3.0 | CN1CCN(c2nc3ccccc3n2CCc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| 2872050 | 206485 | 3 | None | - | 1 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202939 | 206485 | 3 | None | - | 1 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL98605 | 206485 | 3 | None | - | 1 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1 | 10.1021/jm00093a025 | ||
| 2284 | 3133 | 27 | None | -11 | 25 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| 4926 | 3133 | 27 | None | -11 | 25 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| 7281 | 3133 | 27 | None | -11 | 25 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| CHEMBL564 | 3133 | 27 | None | -11 | 25 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| DB00420 | 3133 | 27 | None | -11 | 25 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| 9984168 | 97837 | 5 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 288 | 5 | 1 | 5 | 1.9 | CCOCCn1c(N2CCCNCC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL274747 | 97837 | 5 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 288 | 5 | 1 | 5 | 1.9 | CCOCCn1c(N2CCCNCC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 14984033 | 206437 | 1 | None | - | 1 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202941 | 206437 | 1 | None | - | 1 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL98334 | 206437 | 1 | None | - | 1 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| 145993117 | 166368 | 0 | None | -204 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 7 | 0 | 5 | 4.4 | CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1 | 10.1016/j.ejmech.2017.12.099 | ||
| CHEMBL4286717 | 166368 | 0 | None | -204 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 7 | 0 | 5 | 4.4 | CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1 | 10.1016/j.ejmech.2017.12.099 | ||
| 708981 | 88364 | 2 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 2.7 | CN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL23638 | 88364 | 2 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 2.7 | CN1CC[C@@](O)(c2ccccc2)[C@H](C(=O)c2ccccc2)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| 13623337 | 98346 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 300 | 6 | 0 | 4 | 3.4 | CCCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL278457 | 98346 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 300 | 6 | 0 | 4 | 3.4 | CCCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 15585276 | 61637 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 364 | 7 | 0 | 5 | 3.4 | CCOCCn1c(N2CCN(Cc3ccccc3)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17742 | 61637 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 364 | 7 | 0 | 5 | 3.4 | CCOCCn1c(N2CCN(Cc3ccccc3)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 54582000 | 62407 | 4 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 388 | 4 | 0 | 4 | 4.0 | Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C2CCN(C)CC2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783974 | 62407 | 4 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 388 | 4 | 0 | 4 | 4.0 | Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C2CCN(C)CC2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 162910 | 84198 | 6 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2C(=C(c3ccccc3)c3ccccc32)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL22215 | 84198 | 6 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2C(=C(c3ccccc3)c3ccccc32)C1 | 10.1016/s0960-894x(00)00199-2 | ||
| 15542879 | 112326 | 0 | None | -2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330719 | 112326 | 0 | None | -2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 13623357 | 63049 | 0 | None | - | 1 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 287 | 5 | 1 | 5 | 1.4 | CCNCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17959 | 63049 | 0 | None | - | 1 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 287 | 5 | 1 | 5 | 1.4 | CCNCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 10168749 | 205887 | 0 | None | -3 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL95127 | 205887 | 0 | None | -3 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 1227 | 2454 | 35 | None | 2 | 10 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 2331 | 2454 | 35 | None | 2 | 10 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 3957 | 2454 | 35 | None | 2 | 10 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 4992 | 2454 | 35 | None | 2 | 10 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 10 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| DB06691 | 2454 | 35 | None | 2 | 10 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 44126326 | 197938 | 6 | None | 32 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 322 | 3 | 0 | 2 | 4.3 | Cc1ccc2c(c1)c1c(n2CCc2ccc(F)cc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL592753 | 197938 | 6 | None | 32 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 322 | 3 | 0 | 2 | 4.3 | Cc1ccc2c(c1)c1c(n2CCc2ccc(F)cc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 13623361 | 64314 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 344 | 9 | 0 | 5 | 3.4 | CCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL18181 | 64314 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 344 | 9 | 0 | 5 | 3.4 | CCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 145993493 | 166803 | 0 | None | -38 | 6 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 439 | 6 | 0 | 5 | 4.5 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2017.12.099 | ||
| CHEMBL4294617 | 166803 | 0 | None | -38 | 6 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 439 | 6 | 0 | 5 | 4.5 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1 | 10.1016/j.ejmech.2017.12.099 | ||
| 9918576 | 205606 | 0 | None | -2 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL93556 | 205606 | 0 | None | -2 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
| 44126328 | 199420 | 4 | None | 74 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 322 | 3 | 0 | 2 | 4.3 | Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL603049 | 199420 | 4 | None | 74 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 322 | 3 | 0 | 2 | 4.3 | Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| 13623363 | 98579 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 378 | 8 | 0 | 5 | 3.4 | CCOCCn1c(N2CCN(CCc3ccccc3)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL280255 | 98579 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 378 | 8 | 0 | 5 | 3.4 | CCOCCn1c(N2CCN(CCc3ccccc3)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 14984031 | 206632 | 1 | None | - | 1 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1cccc(F)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202933 | 206632 | 1 | None | - | 1 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1cccc(F)c1 | 10.1021/jm00093a025 | ||
| CHEMBL99529 | 206632 | 1 | None | - | 1 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1cccc(F)c1 | 10.1021/jm00093a025 | ||
| 44126330 | 62395 | 4 | None | -2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783960 | 62395 | 4 | None | -2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 46225027 | 197438 | 4 | None | 74 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 338 | 4 | 0 | 3 | 4.0 | COc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589150 | 197438 | 4 | None | 74 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 338 | 4 | 0 | 3 | 4.0 | COc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| 54583938 | 62404 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 306 | 3 | 0 | 4 | 3.0 | Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783970 | 62404 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 306 | 3 | 0 | 4 | 3.0 | Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 2773179 | 98264 | 5 | None | - | 1 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 230 | 1 | 0 | 4 | 1.3 | CN1CCN(c2nc3ccccc3n2C)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL277749 | 98264 | 5 | None | - | 1 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 230 | 1 | 0 | 4 | 1.3 | CN1CCN(c2nc3ccccc3n2C)CC1 | 10.1021/jm00157a010 | ||
| 46224877 | 199017 | 5 | None | 74 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 288 | 2 | 0 | 2 | 4.3 | CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL599913 | 199017 | 5 | None | 74 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 288 | 2 | 0 | 2 | 4.3 | CN1CCc2c(c3ccccc3n2/C=C\c2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(00)00199-2 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(00)00199-2 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(00)00199-2 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(00)00199-2 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(00)00199-2 | ||
| 10123040 | 160548 | 0 | None | -7 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL411691 | 160548 | 0 | None | -7 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL537027 | 160548 | 0 | None | -7 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 46224878 | 197788 | 0 | None | 2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 290 | 2 | 0 | 2 | 4.0 | CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL591568 | 197788 | 0 | None | 2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 290 | 2 | 0 | 2 | 4.0 | CN1CCC2C(C1)c1ccccc1N2/C=C/c1ccccc1 | 10.1016/j.bmcl.2009.11.037 | ||
| 46225002 | 197813 | 4 | None | 602 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 376 | 3 | 0 | 2 | 5.0 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccc(C(F)(F)F)cc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL591803 | 197813 | 4 | None | 602 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 376 | 3 | 0 | 2 | 5.0 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccc(C(F)(F)F)cc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 11291 | 98340 | 21 | None | - | 1 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL278398 | 98340 | 21 | None | - | 1 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1016/s0960-894x(00)00199-2 | ||
| 10233656 | 206115 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL96442 | 206115 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 13623343 | 98049 | 0 | None | - | 1 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 316 | 7 | 0 | 5 | 2.6 | CCCCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL276070 | 98049 | 0 | None | - | 1 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 316 | 7 | 0 | 5 | 2.6 | CCCCOCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623334 | 63592 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 258 | 3 | 0 | 4 | 2.2 | CCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL18062 | 63592 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 258 | 3 | 0 | 4 | 2.2 | CCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 10122529 | 109068 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL322194 | 109068 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
| 54581997 | 62401 | 6 | None | 11 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 321 | 4 | 0 | 4 | 3.3 | COc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783966 | 62401 | 6 | None | 11 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 321 | 4 | 0 | 4 | 3.3 | COc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 621659 | 62400 | 10 | None | -2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783965 | 62400 | 10 | None | -2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 10123040 | 160548 | 0 | None | -7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL411691 | 160548 | 0 | None | -7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL537027 | 160548 | 0 | None | -7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10212725 | 97717 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 790 | 15 | 1 | 11 | 6.6 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL273915 | 97717 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 790 | 15 | 1 | 11 | 6.6 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 46225000 | 197436 | 4 | None | 9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 308 | 3 | 0 | 2 | 4.0 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589148 | 197436 | 4 | None | 9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 308 | 3 | 0 | 2 | 4.0 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 42631003 | 197937 | 10 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL592752 | 197937 | 10 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 14984030 | 106846 | 1 | None | - | 1 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 279 | 5 | 1 | 4 | 1.8 | CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202935 | 106846 | 1 | None | - | 1 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 279 | 5 | 1 | 4 | 1.8 | CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL317518 | 106846 | 1 | None | - | 1 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 279 | 5 | 1 | 4 | 1.8 | CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1 | 10.1021/jm00093a025 | ||
| 44224259 | 62394 | 4 | None | 30 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783959 | 62394 | 4 | None | 30 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623358 | 98284 | 1 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 260 | 3 | 1 | 5 | 0.8 | CN1CCN(c2nc3ccccc3n2CCO)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL277956 | 98284 | 1 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 260 | 3 | 1 | 5 | 0.8 | CN1CCN(c2nc3ccccc3n2CCO)CC1 | 10.1021/jm00157a010 | ||
| 15542881 | 112095 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330172 | 112095 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 145966333 | 163508 | 0 | None | -346 | 6 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 3.6 | CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1 | 10.1016/j.bmcl.2018.01.038 | ||
| CHEMBL4209188 | 163508 | 0 | None | -346 | 6 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 3.6 | CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1 | 10.1016/j.bmcl.2018.01.038 | ||
| 13623355 | 64013 | 0 | None | - | 1 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 304 | 6 | 1 | 6 | 0.8 | CN1CCN(c2nc3ccccc3n2CCOCCO)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL18122 | 64013 | 0 | None | - | 1 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 304 | 6 | 1 | 6 | 0.8 | CN1CCN(c2nc3ccccc3n2CCOCCO)CC1 | 10.1021/jm00157a010 | ||
| 242 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2017.12.099 | ||
| 34 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2017.12.099 | ||
| 60795 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2017.12.099 | ||
| CHEMBL1112 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2017.12.099 | ||
| DB01238 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2017.12.099 | ||
| 242 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2018.01.038 | ||
| 34 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2018.01.038 | ||
| 60795 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2018.01.038 | ||
| CHEMBL1112 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2018.01.038 | ||
| DB01238 | 467 | 117 | None | -123 | 11 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2018.01.038 | ||
| 13623339 | 62965 | 0 | None | - | 1 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 356 | 10 | 0 | 4 | 4.9 | CCCCCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17931 | 62965 | 0 | None | - | 1 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 356 | 10 | 0 | 4 | 4.9 | CCCCCCCCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 13623356 | 62163 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 350 | 6 | 0 | 5 | 3.0 | CN1CCN(c2nc3ccccc3n2CCOCc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL17808 | 62163 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 350 | 6 | 0 | 5 | 3.0 | CN1CCN(c2nc3ccccc3n2CCOCc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| 10283825 | 96245 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL264007 | 96245 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 10147107 | 205886 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL431850 | 205886 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL95125 | 205886 | 0 | None | -3 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 145964299 | 163580 | 0 | None | -489 | 6 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 426 | 8 | 1 | 6 | 3.8 | CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1 | 10.1016/j.bmcl.2018.01.038 | ||
| CHEMBL4210030 | 163580 | 0 | None | -489 | 6 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 426 | 8 | 1 | 6 | 3.8 | CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1 | 10.1016/j.bmcl.2018.01.038 | ||
| 44327909 | 111866 | 0 | None | -37 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 706 | 14 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL329450 | 111866 | 0 | None | -37 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 706 | 14 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 736282 | 77786 | 11 | None | -3 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 337 | 6 | 1 | 3 | 4.2 | CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL2103769 | 77786 | 11 | None | -3 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 337 | 6 | 1 | 3 | 4.2 | CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1 | 10.1021/jm300671m | ||
| 2389 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2017.12.099 | ||
| 5073 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2017.12.099 | ||
| 96 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2017.12.099 | ||
| CHEMBL85 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2017.12.099 | ||
| DB00734 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2017.12.099 | ||
| 2389 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2018.01.038 | ||
| 5073 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2018.01.038 | ||
| 96 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2018.01.038 | ||
| CHEMBL85 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2018.01.038 | ||
| DB00734 | 3279 | 114 | None | -223 | 22 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2018.01.038 | ||
| 1227 | 2454 | 35 | None | 2 | 10 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 2331 | 2454 | 35 | None | 2 | 10 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 3957 | 2454 | 35 | None | 2 | 10 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 4992 | 2454 | 35 | None | 2 | 10 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 10 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| DB06691 | 2454 | 35 | None | 2 | 10 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 75201901 | 165872 | 14 | None | -208 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.8b01622 | ||
| CHEMBL4277264 | 165872 | 14 | None | -208 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.8b01622 | ||
| 54582938 | 62390 | 6 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 321 | 4 | 0 | 4 | 3.3 | COc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783955 | 62390 | 6 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 321 | 4 | 0 | 4 | 3.3 | COc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54580942 | 62402 | 9 | None | 13 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783967 | 62402 | 9 | None | 13 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 10315027 | 98472 | 0 | None | - | 1 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 337 | 3 | 0 | 1 | 5.5 | c1ccc(CN2CCC3=C(C2)C(c2ccccc2)c2ccccc23)cc1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL279454 | 98472 | 0 | None | - | 1 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 337 | 3 | 0 | 1 | 5.5 | c1ccc(CN2CCC3=C(C2)C(c2ccccc2)c2ccccc23)cc1 | 10.1016/s0960-894x(00)00199-2 | ||
| 15542673 | 205830 | 0 | None | -1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL94834 | 205830 | 0 | None | -1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 10305888 | 205821 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 750 | 14 | 1 | 9 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL94788 | 205821 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 750 | 14 | 1 | 9 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 44328321 | 167225 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 788 | 17 | 1 | 10 | 7.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL430471 | 167225 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 788 | 17 | 1 | 10 | 7.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10305069 | 206114 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 656 | 12 | 1 | 9 | 5.4 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL96441 | 206114 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 656 | 12 | 1 | 9 | 5.4 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10234086 | 111144 | 0 | None | -6 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL328511 | 111144 | 0 | None | -6 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| 13623335 | 98345 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 272 | 4 | 0 | 4 | 2.6 | CCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL278456 | 98345 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 272 | 4 | 0 | 4 | 2.6 | CCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 10121390 | 112242 | 0 | None | -3 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL330499 | 112242 | 0 | None | -3 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 10190413 | 205598 | 0 | None | -3 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL410270 | 205598 | 0 | None | -3 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL93519 | 205598 | 0 | None | -3 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| 54579957 | 62399 | 4 | None | 36 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783964 | 62399 | 4 | None | 36 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccncc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 44126329 | 62389 | 6 | None | -2 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783954 | 62389 | 6 | None | -2 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2ccccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 44126330 | 62395 | 4 | None | -2 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783960 | 62395 | 4 | None | -2 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 305 | 3 | 0 | 3 | 3.6 | Cc1ccc2c(c1)c1c(n2CCc2cccnc2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623348 | 58733 | 0 | None | - | 1 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 300 | 5 | 0 | 4 | 3.2 | CCCC(C)Cn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL16939 | 58733 | 0 | None | - | 1 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 300 | 5 | 0 | 4 | 3.2 | CCCC(C)Cn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 10423703 | 106811 | 0 | None | - | 1 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202942 | 106811 | 0 | None | - | 1 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL317171 | 106811 | 0 | None | - | 1 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| 10300214 | 83784 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 492 | 9 | 2 | 5 | 5.0 | O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208416 | 83784 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 492 | 9 | 2 | 5 | 5.0 | O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 15830914 | 98449 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 245 | 1 | 1 | 1 | 3.5 | C1=C2C(=C(c3ccccc3)c3ccccc32)CNC1 | 10.1016/s0960-894x(00)00199-2 | ||
| CHEMBL279297 | 98449 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 245 | 1 | 1 | 1 | 3.5 | C1=C2C(=C(c3ccccc3)c3ccccc32)CNC1 | 10.1016/s0960-894x(00)00199-2 | ||
| 13623351 | 60828 | 0 | None | - | 1 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 318 | 6 | 0 | 5 | 2.9 | CCSCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17655 | 60828 | 0 | None | - | 1 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 318 | 6 | 0 | 5 | 2.9 | CCSCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 54582940 | 62393 | 4 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 359 | 3 | 0 | 3 | 4.3 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783958 | 62393 | 4 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 359 | 3 | 0 | 3 | 4.3 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 2600 | 3720 | 73 | None | 2 | 16 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(97)10097-X | ||
| 2608 | 3720 | 73 | None | 2 | 16 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(97)10097-X | ||
| 5405 | 3720 | 73 | None | 2 | 16 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL17157 | 3720 | 73 | None | 2 | 16 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(97)10097-X | ||
| DB00342 | 3720 | 73 | None | 2 | 16 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(97)10097-X | ||
| 10917690 | 205871 | 0 | None | -3 | 4 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL95051 | 205871 | 0 | None | -3 | 4 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
| 44328320 | 205867 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 802 | 17 | 0 | 11 | 7.5 | COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL95029 | 205867 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 802 | 17 | 0 | 11 | 7.5 | COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| 10147218 | 106980 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 778 | 15 | 0 | 10 | 7.5 | CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL318369 | 106980 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 778 | 15 | 0 | 10 | 7.5 | CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| 10169609 | 205911 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 804 | 15 | 0 | 12 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL95243 | 205911 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 804 | 15 | 0 | 12 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| 3219 | 198113 | 56 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 302 | 5 | 0 | 5 | 2.2 | CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL594 | 198113 | 56 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 302 | 5 | 0 | 5 | 2.2 | CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 44328188 | 111038 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 728 | 16 | 0 | 11 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL327888 | 111038 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 728 | 16 | 0 | 11 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| 15542880 | 205773 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 705 | 12 | 0 | 9 | 6.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL94480 | 205773 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 705 | 12 | 0 | 9 | 6.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10284042 | 206247 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 777 | 13 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL97240 | 206247 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 777 | 13 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10121390 | 112242 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL330499 | 112242 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10190413 | 205598 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL410270 | 205598 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL93519 | 205598 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| 15542673 | 205830 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL94834 | 205830 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 15542869 | 205875 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 720 | 15 | 0 | 10 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL95076 | 205875 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 720 | 15 | 0 | 10 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10283825 | 96245 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL264007 | 96245 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10147107 | 205886 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL431850 | 205886 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL95125 | 205886 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 15542881 | 112095 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL330172 | 112095 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 15542679 | 108040 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 664 | 10 | 1 | 7 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL320003 | 108040 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 664 | 10 | 1 | 7 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10122529 | 109068 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL322194 | 109068 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| 10233656 | 206115 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL96442 | 206115 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 18333241 | 206058 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 736 | 14 | 0 | 9 | 7.2 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL96141 | 206058 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 736 | 14 | 0 | 9 | 7.2 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| 9918576 | 205606 | 0 | None | -2 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL93556 | 205606 | 0 | None | -2 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10168749 | 205887 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL95127 | 205887 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 15542879 | 112326 | 0 | None | -2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL330719 | 112326 | 0 | None | -2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10190770 | 206275 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL330430 | 206275 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL97357 | 206275 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10190638 | 205808 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL94726 | 205808 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10283765 | 107601 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 730 | 12 | 0 | 8 | 7.4 | CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL319535 | 107601 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 730 | 12 | 0 | 8 | 7.4 | CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 | 10.1016/S0960-894X(97)10098-1 | ||
| 18333379 | 205841 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 686 | 15 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL94906 | 205841 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 686 | 15 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
| 10190056 | 110950 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL327497 | 110950 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10212223 | 206399 | 0 | None | -2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL431458 | 206399 | 0 | None | -2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL98079 | 206399 | 0 | None | -2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 15542874 | 111677 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 786 | 12 | 0 | 8 | 8.7 | COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL329055 | 111677 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 786 | 12 | 0 | 8 | 8.7 | COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 10123138 | 108039 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL317524 | 108039 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL320002 | 108039 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
| 9832306 | 112227 | 0 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL330367 | 112227 | 0 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL330462 | 112227 | 0 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10098-1 | ||
| 15542871 | 206119 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 726 | 9 | 0 | 7 | 8.0 | O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL96466 | 206119 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 726 | 9 | 0 | 7 | 8.0 | O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 | 10.1016/S0960-894X(97)10098-1 | ||
| 3071016 | 98126 | 1 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 336 | 5 | 0 | 5 | 2.9 | CN1CCN(c2nc3ccccc3n2CCOc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL276735 | 98126 | 1 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 336 | 5 | 0 | 5 | 2.9 | CN1CCN(c2nc3ccccc3n2CCOc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| 14984032 | 206600 | 1 | None | - | 1 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202932 | 206600 | 1 | None | - | 1 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1 | 10.1021/jm00093a025 | ||
| CHEMBL99350 | 206600 | 1 | None | - | 1 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1 | 10.1021/jm00093a025 | ||
| 54579956 | 62391 | 4 | None | 3 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783956 | 62391 | 4 | None | 3 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54586813 | 62396 | 4 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783961 | 62396 | 4 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 44126325 | 197435 | 4 | None | 10 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 334 | 4 | 0 | 3 | 4.2 | COc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589147 | 197435 | 4 | None | 10 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 334 | 4 | 0 | 3 | 4.2 | COc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1 | 10.1016/j.bmcl.2009.11.037 | ||
| 44126272 | 197471 | 4 | None | 14 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 358 | 3 | 0 | 2 | 4.9 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL589388 | 197471 | 4 | None | 14 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 358 | 3 | 0 | 2 | 4.9 | CN1CCc2c(c3cc(C(F)(F)F)ccc3n2CCc2ccccc2)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 13623349 | 98131 | 0 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 304 | 5 | 0 | 5 | 2.9 | CCCSCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL276774 | 98131 | 0 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 304 | 5 | 0 | 5 | 2.9 | CCCSCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 16082828 | 79850 | 0 | None | -398 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 275 | 6 | 2 | 2 | 3.3 | Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1 | 10.1021/jm0603318 | ||
| CHEMBL213886 | 79850 | 0 | None | -398 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 275 | 6 | 2 | 2 | 3.3 | Clc1ccc(CNCC[C@@H]2C[C@H]2c2c[nH]cn2)cc1 | 10.1021/jm0603318 | ||
| 10917690 | 205871 | 0 | None | -3 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL95051 | 205871 | 0 | None | -3 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| 44328187 | 206398 | 0 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 456 | 7 | 0 | 5 | 5.6 | COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| CHEMBL98076 | 206398 | 0 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 456 | 7 | 0 | 5 | 5.6 | COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
| 13623370 | 97939 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 358 | 9 | 0 | 5 | 3.8 | CCCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL275383 | 97939 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 358 | 9 | 0 | 5 | 3.8 | CCCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 46224879 | 199862 | 3 | None | -1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 302 | 2 | 0 | 2 | 4.6 | Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL605405 | 199862 | 3 | None | -1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 302 | 2 | 0 | 2 | 4.6 | Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 54581998 | 62406 | 4 | None | 5 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 368 | 4 | 0 | 4 | 4.3 | CN1CCc2c(c3cc(-c4cccnc4)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783972 | 62406 | 4 | None | 5 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 368 | 4 | 0 | 4 | 4.3 | CN1CCc2c(c3cc(-c4cccnc4)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54585846 | 62398 | 4 | None | 38 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 3.7 | Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783963 | 62398 | 4 | None | 38 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 3.7 | Cc1ccc(CCn2c3c(c4cc(F)ccc42)CN(C)CC3)cn1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54583939 | 62408 | 4 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 388 | 4 | 0 | 4 | 4.0 | Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C2CCN(C)CC2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783975 | 62408 | 4 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 388 | 4 | 0 | 4 | 4.0 | Cc1ccc2c(c1)c1c(n2CCc2ccncc2)CCN(C2CCN(C)CC2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623340 | 58732 | 0 | None | - | 1 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 292 | 2 | 0 | 4 | 2.8 | CN1CCN(c2nc3ccccc3n2-c2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL16938 | 58732 | 0 | None | - | 1 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 292 | 2 | 0 | 4 | 2.8 | CN1CCN(c2nc3ccccc3n2-c2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| 54583938 | 62404 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 306 | 3 | 0 | 4 | 3.0 | Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783970 | 62404 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 306 | 3 | 0 | 4 | 3.0 | Cc1ccc2c(c1)c1c(n2CCc2cnccn2)CCN(C)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 13623369 | 62064 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 344 | 8 | 0 | 5 | 3.4 | CCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL17795 | 62064 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 344 | 8 | 0 | 5 | 3.4 | CCCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 13623368 | 161696 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 330 | 7 | 0 | 5 | 3.0 | CCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL416357 | 161696 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 330 | 7 | 0 | 5 | 3.0 | CCCN1CCCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 13623362 | 97632 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 358 | 10 | 0 | 5 | 3.8 | CCCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL273315 | 97632 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 358 | 10 | 0 | 5 | 3.8 | CCCCCCN1CCN(c2nc3ccccc3n2CCOCC)CC1 | 10.1021/jm00157a010 | ||
| 16082831 | 79936 | 0 | None | -1000 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 275 | 6 | 2 | 2 | 3.3 | Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1 | 10.1021/jm0603318 | ||
| CHEMBL214311 | 79936 | 0 | None | -1000 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 275 | 6 | 2 | 2 | 3.3 | Clc1ccc(CNCC[C@H]2C[C@@H]2c2c[nH]cn2)cc1 | 10.1021/jm0603318 | ||
| 13623353 | 60175 | 0 | None | - | 1 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 288 | 5 | 0 | 5 | 1.8 | COCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL17556 | 60175 | 0 | None | - | 1 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 288 | 5 | 0 | 5 | 1.8 | COCCCn1c(N2CCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 11976 | 907 | 54 | None | -9 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| 667467 | 907 | 54 | None | -9 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| CHEMBL908 | 907 | 54 | None | -9 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| DB01239 | 907 | 54 | None | -9 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| 3071012 | 162739 | 1 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 350 | 5 | 0 | 5 | 3.3 | CN1CCCN(c2nc3ccccc3n2CCOc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| CHEMBL418731 | 162739 | 1 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 350 | 5 | 0 | 5 | 3.3 | CN1CCCN(c2nc3ccccc3n2CCOc2ccccc2)CC1 | 10.1021/jm00157a010 | ||
| 3070998 | 98524 | 1 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 312 | 5 | 0 | 5 | 1.8 | C#CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| CHEMBL279875 | 98524 | 1 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 312 | 5 | 0 | 5 | 1.8 | C#CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | 10.1021/jm00157a010 | ||
| 145963961 | 163851 | 0 | None | -416 | 6 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 425 | 8 | 1 | 7 | 3.0 | CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1 | 10.1016/j.bmcl.2018.01.038 | ||
| CHEMBL4213342 | 163851 | 0 | None | -416 | 6 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 425 | 8 | 1 | 7 | 3.0 | CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1 | 10.1016/j.bmcl.2018.01.038 | ||
| 54586812 | 62388 | 4 | None | 12 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783953 | 62388 | 4 | None | 12 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 291 | 3 | 0 | 3 | 3.3 | CN1CCc2c(c3ccccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54586813 | 62396 | 4 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783961 | 62396 | 4 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2cccnc2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 54579956 | 62391 | 4 | None | 3 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| CHEMBL1783956 | 62391 | 4 | None | 3 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 309 | 3 | 0 | 3 | 3.4 | CN1CCc2c(c3cc(F)ccc3n2CCc2ccccn2)C1 | 10.1016/j.bmcl.2009.04.128 | ||
| 10212645 | 13178 | 0 | None | -346 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 774 | 16 | 1 | 10 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL1191766 | 13178 | 0 | None | -346 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 774 | 16 | 1 | 10 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL542908 | 13178 | 0 | None | -346 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 774 | 16 | 1 | 10 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
| 4601 | 205020 | 29 | None | -549 | 15 | Human | 4.0 | pIC50 | = | 4.0 | Functional | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL1201023 | 205020 | 29 | None | -549 | 15 | Human | 4.0 | pIC50 | = | 4.0 | Functional | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL900 | 205020 | 29 | None | -549 | 15 | Human | 4.0 | pIC50 | = | 4.0 | Functional | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | 10.1021/jm300671m | ||
| 44126327 | 199968 | 4 | None | 41 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 372 | 3 | 0 | 2 | 5.2 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)cc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| CHEMBL606036 | 199968 | 4 | None | 41 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 372 | 3 | 0 | 2 | 5.2 | Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)cc2)CCN(C)C1 | 10.1016/j.bmcl.2009.11.037 | ||
| 10190842 | 106740 | 0 | None | -63 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 788 | 16 | 0 | 11 | 7.1 | COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
| CHEMBL316705 | 106740 | 0 | None | -63 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 788 | 16 | 0 | 11 | 7.1 | COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
| 71461781 | 80059 | 0 | None | - | 0 | Human | 10.4 | pKd | = | 10.4 | Functional | ChEMBL | 409 | 7 | 0 | 4 | 4.9 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146802 | 80059 | 0 | None | - | 0 | Human | 10.4 | pKd | = | 10.4 | Functional | ChEMBL | 409 | 7 | 0 | 4 | 4.9 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 15254720 | 60972 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL1767136 | 60972 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71461782 | 80063 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146806 | 80063 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2017.09.020 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2017.09.020 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2017.09.020 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2017.09.020 | ||
| 24824726 | 160562 | 1 | None | - | 0 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 496 | 11 | 1 | 6 | 3.6 | COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4060529 | 160562 | 1 | None | - | 0 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 496 | 11 | 1 | 6 | 3.6 | COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117079 | 160562 | 1 | None | - | 0 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 496 | 11 | 1 | 6 | 3.6 | COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmcl.2017.09.020 | ||
| 25189511 | 160571 | 0 | None | - | 0 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 461 | 13 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4059750 | 160571 | 0 | None | - | 0 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 461 | 13 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117137 | 160571 | 0 | None | - | 0 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 461 | 13 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| 71452871 | 80058 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146801 | 80058 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 25190195 | 157370 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 446 | 9 | 0 | 5 | 5.0 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4084325 | 157370 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 446 | 9 | 0 | 5 | 5.0 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 71458203 | 80062 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146805 | 80062 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71451044 | 80064 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146807 | 80064 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71458204 | 80066 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146809 | 80066 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 1530 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00161a022 | ||
| 3827 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00161a022 | ||
| 7206 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00161a022 | ||
| CHEMBL534 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00161a022 | ||
| DB00920 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00161a022 | ||
| 1530 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00377a013 | ||
| 3827 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00377a013 | ||
| 7206 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00377a013 | ||
| CHEMBL534 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00377a013 | ||
| DB00920 | 2151 | 44 | None | - | 21 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00377a013 | ||
| 25190192 | 160448 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 418 | 10 | 0 | 5 | 4.2 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4098917 | 160448 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 418 | 10 | 0 | 5 | 4.2 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4116155 | 160448 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 418 | 10 | 0 | 5 | 4.2 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(03)00113-6 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(03)00113-6 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(03)00113-6 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(03)00113-6 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/s0960-894x(03)00113-6 | ||
| 25190372 | 160428 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 433 | 11 | 1 | 5 | 3.8 | CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4098192 | 160428 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 433 | 11 | 1 | 5 | 3.8 | CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4115992 | 160428 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 433 | 11 | 1 | 5 | 3.8 | CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 25190194 | 160615 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4102287 | 160615 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117432 | 160615 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 71452872 | 80024 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146484 | 80024 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 25164129 | 160613 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 447 | 12 | 1 | 5 | 4.1 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4088036 | 160613 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 447 | 12 | 1 | 5 | 4.1 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117406 | 160613 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 447 | 12 | 1 | 5 | 4.1 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 25189509 | 160525 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 461 | 10 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4069073 | 160525 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 461 | 10 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4116734 | 160525 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 461 | 10 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 44320707 | 105550 | 0 | None | - | 0 | Guinea pig | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 293 | 4 | 1 | 2 | 2.9 | CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL313301 | 105550 | 0 | None | - | 0 | Guinea pig | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 293 | 4 | 1 | 2 | 2.9 | CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 10403687 | 2475 | 2 | None | 1 | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | 1 | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | 1 | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 25190193 | 160652 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 432 | 11 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4080880 | 160652 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 432 | 11 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117740 | 160652 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 432 | 11 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 1194 | 46 | 3 | None | - | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/s0960-894x(98)00461-2 | ||
| 23786499 | 46 | 3 | None | - | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL26116 | 46 | 3 | None | - | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/s0960-894x(98)00461-2 | ||
| 44320708 | 204652 | 0 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 295 | 5 | 2 | 2 | 3.4 | FC(F)(F)c1cccc(-c2nc(CCNC3CC3)c[nH]2)c1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL87583 | 204652 | 0 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 295 | 5 | 2 | 2 | 3.4 | FC(F)(F)c1cccc(-c2nc(CCNC3CC3)c[nH]2)c1 | 10.1016/s0960-894x(98)00461-2 | ||
| 44320686 | 204727 | 1 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 279 | 4 | 2 | 2 | 2.6 | CNCCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL88075 | 204727 | 1 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 279 | 4 | 2 | 2 | 2.6 | CNCCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 10447834 | 1902 | 4 | None | 2 | 3 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | 2 | 3 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | 2 | 3 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 17747460 | 61000 | 8 | None | - | 2 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL1767164 | 61000 | 8 | None | - | 2 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| 71456360 | 80065 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146808 | 80065 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 17747460 | 61000 | 8 | None | - | 2 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL1767164 | 61000 | 8 | None | - | 2 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmcl.2016.11.022 | ||
| 17747460 | 61000 | 8 | None | - | 2 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767164 | 61000 | 8 | None | - | 2 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00161a022 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00161a022 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00161a022 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00161a022 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00161a022 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00161a022 | ||
| 13676700 | 203076 | 0 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 453 | 7 | 1 | 8 | 3.7 | Oc1c2nnnc-2oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc12 | 10.1021/jm00161a022 | ||
| CHEMBL74870 | 203076 | 0 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 453 | 7 | 1 | 8 | 3.7 | Oc1c2nnnc-2oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc12 | 10.1021/jm00161a022 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00377a013 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00377a013 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00377a013 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00377a013 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00377a013 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00377a013 | ||
| 25190374 | 160631 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 475 | 13 | 1 | 5 | 4.8 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4082646 | 160631 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 475 | 13 | 1 | 5 | 4.8 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117608 | 160631 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 475 | 13 | 1 | 5 | 4.8 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 9993212 | 204485 | 1 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 269 | 4 | 2 | 2 | 2.9 | CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL86522 | 204485 | 1 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 269 | 4 | 2 | 2 | 2.9 | CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/0960-894X(95)00092-8 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/0960-894X(95)00092-8 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/0960-894X(95)00092-8 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/0960-894X(95)00092-8 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/0960-894X(95)00092-8 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/0960-894X(95)00092-8 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/s0960-894x(98)00461-2 | ||
| 5310982 | 93179 | 4 | None | - | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL24665 | 93179 | 4 | None | - | 2 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 9993212 | 204485 | 1 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 269 | 4 | 2 | 2 | 2.9 | CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL86522 | 204485 | 1 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 269 | 4 | 2 | 2 | 2.9 | CNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 10689833 | 12657 | 0 | None | 4 | 2 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 359 | 8 | 1 | 2 | 4.8 | c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL11879 | 12657 | 0 | None | 4 | 2 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 359 | 8 | 1 | 2 | 4.8 | c1ccc(C(CCc2nc(CCN3CCCC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 10447834 | 1902 | 4 | None | 2 | 3 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | 2 | 3 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | 2 | 3 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 5310982 | 93179 | 4 | None | - | 2 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL24665 | 93179 | 4 | None | - | 2 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 44320686 | 204727 | 1 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 279 | 4 | 2 | 2 | 2.6 | CNCCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL88075 | 204727 | 1 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 279 | 4 | 2 | 2 | 2.6 | CNCCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 24804150 | 80070 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 641 | 14 | 0 | 7 | 7.2 | O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146813 | 80070 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 641 | 14 | 0 | 7 | 7.2 | O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| 25189510 | 155568 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 461 | 13 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCS(=O)(=O)NCCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4063163 | 155568 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 461 | 13 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCS(=O)(=O)NCCC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 25190375 | 160537 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 501 | 12 | 1 | 5 | 5.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4088039 | 160537 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 501 | 12 | 1 | 5 | 5.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4116791 | 160537 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 501 | 12 | 1 | 5 | 5.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 25190431 | 160666 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 461 | 12 | 0 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4065123 | 160666 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 461 | 12 | 0 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117871 | 160666 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 461 | 12 | 0 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 54710796 | 119917 | 0 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 473 | 8 | 1 | 8 | 3.6 | O=c1oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| CHEMBL35376 | 119917 | 0 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 473 | 8 | 1 | 8 | 3.6 | O=c1oc2cc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00093a025 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00093a025 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00093a025 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00093a025 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00093a025 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm00093a025 | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 9.0 | pKd | = | 9 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 44320685 | 204726 | 0 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 283 | 5 | 2 | 2 | 3.2 | CCNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL88074 | 204726 | 0 | None | - | 0 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 283 | 5 | 2 | 2 | 3.2 | CCNCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 1227 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2008.09.019 | ||
| 2331 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2008.09.019 | ||
| 3957 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2008.09.019 | ||
| 4992 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2008.09.019 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2008.09.019 | ||
| DB06691 | 2454 | 35 | None | -2 | 10 | Guinea pig | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2008.09.019 | ||
| 44320707 | 105550 | 0 | None | - | 0 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 293 | 4 | 1 | 2 | 2.9 | CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL313301 | 105550 | 0 | None | - | 0 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 293 | 4 | 1 | 2 | 2.9 | CN(C)CCc1c[nH]c(-c2cccc(Br)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 10407870 | 106278 | 0 | None | - | 0 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 283 | 4 | 1 | 2 | 3.2 | CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL314438 | 106278 | 0 | None | - | 0 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 283 | 4 | 1 | 2 | 3.2 | CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 25190317 | 160511 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 433 | 11 | 1 | 5 | 3.8 | CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4080166 | 160511 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 433 | 11 | 1 | 5 | 3.8 | CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4116610 | 160511 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 433 | 11 | 1 | 5 | 3.8 | CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 24803638 | 61001 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 636 | 15 | 0 | 7 | 7.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767165 | 61001 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 636 | 15 | 0 | 7 | 7.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| 24803483 | 61003 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 654 | 15 | 0 | 6 | 8.2 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767167 | 61003 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 654 | 15 | 0 | 6 | 8.2 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 1194 | 46 | 3 | None | - | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/s0960-894x(98)00461-2 | ||
| 23786499 | 46 | 3 | None | - | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL26116 | 46 | 3 | None | - | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 10.1016/s0960-894x(98)00461-2 | ||
| 10403687 | 2475 | 2 | None | 1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | 1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | 1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1524 | 2150 | 89 | None | - | 10 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1016/0960-894X(95)00092-8 | ||
| 197 | 2150 | 89 | None | - | 10 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1016/0960-894X(95)00092-8 | ||
| 3822 | 2150 | 89 | None | - | 10 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1016/0960-894X(95)00092-8 | ||
| 88 | 2150 | 89 | None | - | 10 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1016/0960-894X(95)00092-8 | ||
| CHEMBL51 | 2150 | 89 | None | - | 10 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1016/0960-894X(95)00092-8 | ||
| DB12465 | 2150 | 89 | None | - | 10 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1016/0960-894X(95)00092-8 | ||
| 11791817 | 97851 | 0 | None | -1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL274831 | 97851 | 0 | None | -1 | 2 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 25190253 | 160570 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 460 | 10 | 0 | 5 | 5.4 | CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4095759 | 160570 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 460 | 10 | 0 | 5 | 5.4 | CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117136 | 160570 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 460 | 10 | 0 | 5 | 5.4 | CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 10407870 | 106278 | 0 | None | - | 0 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 283 | 4 | 1 | 2 | 3.2 | CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| CHEMBL314438 | 106278 | 0 | None | - | 0 | Guinea pig | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 283 | 4 | 1 | 2 | 3.2 | CN(C)CCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1016/s0960-894x(98)00461-2 | ||
| 10688111 | 9945 | 0 | None | 2 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.3 | CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL11515 | 9945 | 0 | None | 2 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.3 | CCNCCc1c[nH]c(CCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 57780020 | 142918 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 600 | 15 | 1 | 6 | 6.6 | CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3898341 | 142918 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 600 | 15 | 1 | 6 | 6.6 | CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 10447834 | 1902 | 4 | None | 2 | 3 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | 2 | 3 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | 2 | 3 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 13676694 | 103237 | 0 | None | - | 0 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 467 | 7 | 1 | 8 | 4.0 | Cc1c(OCCCN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| CHEMBL308791 | 103237 | 0 | None | - | 0 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 467 | 7 | 1 | 8 | 4.0 | Cc1c(OCCCN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| 10410901 | 119242 | 0 | None | 23 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL347796 | 119242 | 0 | None | 23 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10403687 | 2475 | 2 | None | 1 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | 1 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | 1 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 10484346 | 98273 | 0 | None | - | 0 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 646 | 22 | 2 | 11 | 5.8 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCCCCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL277848 | 98273 | 0 | None | - | 0 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 646 | 22 | 2 | 11 | 5.8 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCCCCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 25190435 | 157858 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 447 | 9 | 1 | 5 | 4.1 | CCCCc1cc(OC2CCN(CCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4090136 | 157858 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 447 | 9 | 1 | 5 | 4.1 | CCCCc1cc(OC2CCN(CCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 25190373 | 160541 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 461 | 12 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4060765 | 160541 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 461 | 12 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4116847 | 160541 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 461 | 12 | 1 | 5 | 4.5 | CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 25190254 | 160556 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4068414 | 160556 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117012 | 160556 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 3529324 | 206613 | 1 | None | - | 1 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 306 | 6 | 0 | 3 | 3.3 | CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202934 | 206613 | 1 | None | - | 1 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 306 | 6 | 0 | 3 | 3.3 | CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL99417 | 206613 | 1 | None | - | 1 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 306 | 6 | 0 | 3 | 3.3 | CC(C)c1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| 57780008 | 149194 | 0 | None | - | 0 | Human | 8.0 | pKd | = | 8 | Functional | ChEMBL | 472 | 9 | 0 | 5 | 5.2 | c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3947980 | 149194 | 0 | None | - | 0 | Human | 8.0 | pKd | = | 8 | Functional | ChEMBL | 472 | 9 | 0 | 5 | 5.2 | c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm991056a | ||
| 1204 | 1901 | 114 | None | -8 | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1247 | 1901 | 114 | None | -8 | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1375 | 1901 | 114 | None | -8 | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 774 | 1901 | 114 | None | -8 | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| CHEMBL90 | 1901 | 114 | None | -8 | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| DB05381 | 1901 | 114 | None | -8 | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 10364258 | 45512 | 0 | None | -12 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153067 | 45512 | 0 | None | -12 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 57402471 | 67534 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 469 | 8 | 1 | 5 | 4.0 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910378 | 67534 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 469 | 8 | 1 | 5 | 4.0 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 14113352 | 169641 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 394 | 10 | 4 | 4 | 3.4 | N=C(NCCCc1c[nH]cn1)NCCSC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL444531 | 169641 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 394 | 10 | 4 | 4 | 3.4 | N=C(NCCCc1c[nH]cn1)NCCSC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 14984030 | 106846 | 1 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 279 | 5 | 1 | 4 | 1.8 | CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202935 | 106846 | 1 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 279 | 5 | 1 | 4 | 1.8 | CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL317518 | 106846 | 1 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 279 | 5 | 1 | 4 | 1.8 | CN(C)CCCN1C(=O)CSC1c1ccc(N)cc1 | 10.1021/jm00093a025 | ||
| 10246247 | 97841 | 0 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.5 | NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL274767 | 97841 | 0 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.5 | NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 10684712 | 11287 | 0 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 287 | 8 | 2 | 4 | 3.4 | CCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL112301 | 11287 | 0 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 287 | 8 | 2 | 4 | 3.4 | CCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1180048 | 11287 | 0 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 287 | 8 | 2 | 4 | 3.4 | CCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 6422121 | 203738 | 1 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 285 | 7 | 2 | 4 | 3.0 | O/N=C(/c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1 | 10.1021/jm000971p | ||
| CHEMBL116270 | 203738 | 1 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 285 | 7 | 2 | 4 | 3.0 | O/N=C(/c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1 | 10.1021/jm000971p | ||
| CHEMBL80348 | 203738 | 1 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 285 | 7 | 2 | 4 | 3.0 | O/N=C(/c1ccc(OCCCc2c[nH]cn2)cc1)C1CC1 | 10.1021/jm000971p | ||
| 2860933 | 206431 | 3 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202929 | 206431 | 3 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL98319 | 206431 | 3 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| 54726349 | 111877 | 0 | None | - | 0 | Guinea pig | 4.0 | pKd | = | 4 | Functional | ChEMBL | 363 | 6 | 1 | 8 | 1.4 | CN1CCN(CCCOc2ccc3c(O)c([N+](=O)[O-])c(=O)oc3c2)CC1 | 10.1021/jm00377a013 | ||
| CHEMBL32953 | 111877 | 0 | None | - | 0 | Guinea pig | 4.0 | pKd | = | 4 | Functional | ChEMBL | 363 | 6 | 1 | 8 | 1.4 | CN1CCN(CCCOc2ccc3c(O)c([N+](=O)[O-])c(=O)oc3c2)CC1 | 10.1021/jm00377a013 | ||
| 10246247 | 97841 | 0 | None | - | 0 | Rat | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.5 | NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL274767 | 97841 | 0 | None | - | 0 | Rat | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.5 | NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 11779175 | 62836 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 293 | 8 | 2 | 3 | 3.4 | O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1774600 | 62836 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 293 | 8 | 2 | 3 | 3.4 | O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1789801 | 62836 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 293 | 8 | 2 | 3 | 3.4 | O=C(NCCCC1CCCCC1)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| 14660374 | 100223 | 0 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 394 | 9 | 3 | 3 | 3.6 | CN(CCC(c1ccc(F)cc1)c1ccccn1)C(=N)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| CHEMBL292395 | 100223 | 0 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 394 | 9 | 3 | 3 | 3.6 | CN(CCC(c1ccc(F)cc1)c1ccccn1)C(=N)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| 1224 | 1404 | 79 | None | 54 | 13 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 3100 | 1404 | 79 | None | 54 | 13 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 8980 | 1404 | 79 | None | 54 | 13 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 916 | 1404 | 79 | None | 54 | 13 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL657 | 1404 | 79 | None | 54 | 13 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| DB01075 | 1404 | 79 | None | 54 | 13 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 25149611 | 178596 | 0 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 376 | 8 | 4 | 4 | 2.6 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccn1 | 10.1021/jm800841w | ||
| CHEMBL472272 | 178596 | 0 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 376 | 8 | 4 | 4 | 2.6 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccn1 | 10.1021/jm800841w | ||
| 14660410 | 197376 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 396 | 9 | 4 | 4 | 2.1 | N/C(=N\CCC(O)(c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| CHEMBL58621 | 197376 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 396 | 9 | 4 | 4 | 2.1 | N/C(=N\CCC(O)(c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| 57398985 | 67541 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 569 | 12 | 2 | 7 | 4.4 | COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910385 | 67541 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 569 | 12 | 2 | 7 | 4.4 | COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 54710799 | 96333 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 439 | 8 | 1 | 8 | 3.0 | O=c1oc2cc(OCCCN3CCN(Cc4ccccc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| CHEMBL264756 | 96333 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 439 | 8 | 1 | 8 | 3.0 | O=c1oc2cc(OCCCN3CCN(Cc4ccccc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| 19762600 | 79589 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 370 | 13 | 1 | 5 | 3.5 | COc1ccc(CN(CCN(C)CCCCCCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21278 | 79589 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 370 | 13 | 1 | 5 | 3.5 | COc1ccc(CN(CCN(C)CCCCCCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 10003410 | 198958 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 440 | 9 | 4 | 3 | 3.8 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Br)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL59951 | 198958 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 440 | 9 | 4 | 3 | 3.8 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Br)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 10852834 | 11288 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 315 | 10 | 2 | 4 | 4.2 | CCCCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL112629 | 11288 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 315 | 10 | 2 | 4 | 4.2 | CCCCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1180064 | 11288 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 315 | 10 | 2 | 4 | 4.2 | CCCCC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 10659856 | 11292 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 273 | 7 | 1 | 4 | 2.8 | CO/N=C(\C)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL112753 | 11292 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 273 | 7 | 1 | 4 | 2.8 | CO/N=C(\C)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1180075 | 11292 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 273 | 7 | 1 | 4 | 2.8 | CO/N=C(\C)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 10828008 | 11305 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 299 | 6 | 1 | 3 | 2.7 | O=C(c1ccc(OCCCc2c[nH]cn2)cc1)N1CCCC1 | 10.1021/jm000971p | ||
| CHEMBL115169 | 11305 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 299 | 6 | 1 | 3 | 2.7 | O=C(c1ccc(OCCCc2c[nH]cn2)cc1)N1CCCC1 | 10.1021/jm000971p | ||
| CHEMBL1180148 | 11305 | 0 | None | - | 0 | Guinea pig | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 299 | 6 | 1 | 3 | 2.7 | O=C(c1ccc(OCCCc2c[nH]cn2)cc1)N1CCCC1 | 10.1021/jm000971p | ||
| 19762590 | 161713 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 314 | 9 | 1 | 5 | 2.0 | COc1ccc(CN(CCN(C)CCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL416378 | 161713 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 314 | 9 | 1 | 5 | 2.0 | COc1ccc(CN(CCN(C)CCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 25149335 | 183643 | 0 | None | - | 3 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/jm9000693 | ||
| CHEMBL483406 | 183643 | 0 | None | - | 3 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/jm9000693 | ||
| 25149335 | 183643 | 0 | None | - | 3 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/jm800841w | ||
| CHEMBL483406 | 183643 | 0 | None | - | 3 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/jm800841w | ||
| 52949049 | 10455 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 673 | 17 | 1 | 7 | 7.2 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCC2=C3C(C)=CC(C)N3[B-](F)(F)n3c(C)cc(C)c32)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL1169587 | 10455 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 673 | 17 | 1 | 7 | 7.2 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)CCC2=C3C(C)=CC(C)N3[B-](F)(F)n3c(C)cc(C)c32)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 14660389 | 200606 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 393 | 10 | 4 | 2 | 4.0 | N=C(NCCCc1c[nH]cn1)NCCC(Cc1ccccc1)c1ccc(F)cc1 | 10.1021/jm00128a045 | ||
| CHEMBL61022 | 200606 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 393 | 10 | 4 | 2 | 4.0 | N=C(NCCCc1c[nH]cn1)NCCC(Cc1ccccc1)c1ccc(F)cc1 | 10.1021/jm00128a045 | ||
| 44457703 | 99085 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 672 | 13 | 3 | 9 | 5.7 | COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL283527 | 99085 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 672 | 13 | 3 | 9 | 5.7 | COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 14660348 | 197973 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 376 | 9 | 3 | 3 | 3.2 | Cc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1021/jm00128a045 | ||
| CHEMBL59294 | 197973 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 376 | 9 | 3 | 3 | 3.2 | Cc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1021/jm00128a045 | ||
| 13676692 | 105005 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 447 | 7 | 1 | 8 | 3.6 | Cc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1 | 10.1021/jm00161a022 | ||
| CHEMBL312083 | 105005 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 447 | 7 | 1 | 8 | 3.6 | Cc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1 | 10.1021/jm00161a022 | ||
| 13676699 | 163216 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 434 | 7 | 1 | 9 | 2.7 | Cc1c(OCCCN2CCN(Cc3ccccn3)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| CHEMBL420567 | 163216 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 434 | 7 | 1 | 9 | 2.7 | Cc1c(OCCCN2CCN(Cc3ccccn3)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| 14660357 | 201014 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL61675 | 201014 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 54710801 | 99445 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 459 | 7 | 1 | 8 | 3.3 | O=c1oc2cc(OCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| CHEMBL286094 | 99445 | 0 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 459 | 7 | 1 | 8 | 3.3 | O=c1oc2cc(OCCN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| 10825231 | 9539 | 1 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 260 | 6 | 1 | 4 | 2.2 | COC(=O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL112670 | 9539 | 1 | None | - | 0 | Guinea pig | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 260 | 6 | 1 | 4 | 2.2 | COC(=O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 1278 | 2119 | 79 | None | - | 4 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| 1279 | 2119 | 79 | None | - | 4 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| 4908365 | 2119 | 79 | None | - | 4 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL129198 | 2119 | 79 | None | - | 4 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| 15179507 | 202478 | 0 | None | - | 0 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 729 | 11 | 4 | 6 | 3.7 | N#CN/C(=N\CCNC(=O)c1cc(I)c(N)c(I)c1)NCCCOc1cccc(CN2CCCCC2)c1 | 10.1021/jm00090a013 | ||
| CHEMBL70746 | 202478 | 0 | None | - | 0 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 729 | 11 | 4 | 6 | 3.7 | N#CN/C(=N\CCNC(=O)c1cc(I)c(N)c(I)c1)NCCCOc1cccc(CN2CCCCC2)c1 | 10.1021/jm00090a013 | ||
| 11459067 | 11243 | 0 | None | - | 0 | Guinea pig | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 238 | 11 | 1 | 2 | 3.7 | CCCCCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| CHEMBL1179647 | 11243 | 0 | None | - | 0 | Guinea pig | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 238 | 11 | 1 | 2 | 3.7 | CCCCCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| CHEMBL91523 | 11243 | 0 | None | - | 0 | Guinea pig | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 238 | 11 | 1 | 2 | 3.7 | CCCCCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| 10730975 | 11999 | 0 | None | - | 0 | Guinea pig | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 273 | 6 | 2 | 4 | 2.9 | C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)c(C)c1 | 10.1021/jm000971p | ||
| CHEMBL1183977 | 11999 | 0 | None | - | 0 | Guinea pig | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 273 | 6 | 2 | 4 | 2.9 | C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)c(C)c1 | 10.1021/jm000971p | ||
| CHEMBL326624 | 11999 | 0 | None | - | 0 | Guinea pig | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 273 | 6 | 2 | 4 | 2.9 | C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)c(C)c1 | 10.1021/jm000971p | ||
| 14660414 | 197394 | 0 | None | - | 0 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 407 | 10 | 3 | 5 | 2.8 | N/C(=N\CCC(c1cccc([N+](=O)[O-])c1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| CHEMBL58750 | 197394 | 0 | None | - | 0 | Guinea pig | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 407 | 10 | 3 | 5 | 2.8 | N/C(=N\CCC(c1cccc([N+](=O)[O-])c1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| 44457690 | 85101 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 603 | 17 | 1 | 7 | 5.8 | COc1ccc(CN(CCN(C)CCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL22749 | 85101 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 603 | 17 | 1 | 7 | 5.8 | COc1ccc(CN(CCN(C)CCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 25149427 | 185379 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 313 | 8 | 4 | 3 | 2.0 | N=C(NCCCc1c[nH]cn1)NC(=O)CCCc1ccccc1 | 10.1021/jm800841w | ||
| CHEMBL486962 | 185379 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 313 | 8 | 4 | 3 | 2.0 | N=C(NCCCc1c[nH]cn1)NC(=O)CCCc1ccccc1 | 10.1021/jm800841w | ||
| 10423703 | 106811 | 0 | None | - | 1 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202942 | 106811 | 0 | None | - | 1 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL317171 | 106811 | 0 | None | - | 1 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| 14660380 | 197030 | 0 | None | - | 0 | Guinea pig | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)cc1)c1cccnc1 | 10.1021/jm00128a045 | ||
| CHEMBL58170 | 197030 | 0 | None | - | 0 | Guinea pig | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)cc1)c1cccnc1 | 10.1021/jm00128a045 | ||
| 10342634 | 198336 | 0 | None | - | 0 | Guinea pig | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 429 | 9 | 4 | 2 | 5.0 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00128a045 | ||
| CHEMBL59544 | 198336 | 0 | None | - | 0 | Guinea pig | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 429 | 9 | 4 | 2 | 5.0 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00128a045 | ||
| 11436304 | 11232 | 0 | None | - | 0 | Guinea pig | 4.7 | pKd | = | 4.7 | Functional | ChEMBL | 236 | 8 | 1 | 2 | 3.3 | c1nc(CCCOCCCC2CCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL1179594 | 11232 | 0 | None | - | 0 | Guinea pig | 4.7 | pKd | = | 4.7 | Functional | ChEMBL | 236 | 8 | 1 | 2 | 3.3 | c1nc(CCCOCCCC2CCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL88306 | 11232 | 0 | None | - | 0 | Guinea pig | 4.7 | pKd | = | 4.7 | Functional | ChEMBL | 236 | 8 | 1 | 2 | 3.3 | c1nc(CCCOCCCC2CCCC2)c[nH]1 | 10.1021/jm031065q | ||
| 10375442 | 11235 | 0 | None | - | 1 | Guinea pig | 4.7 | pKd | = | 4.7 | Functional | ChEMBL | 196 | 8 | 1 | 2 | 2.5 | CCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| CHEMBL1179604 | 11235 | 0 | None | - | 1 | Guinea pig | 4.7 | pKd | = | 4.7 | Functional | ChEMBL | 196 | 8 | 1 | 2 | 2.5 | CCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| CHEMBL88746 | 11235 | 0 | None | - | 1 | Guinea pig | 4.7 | pKd | = | 4.7 | Functional | ChEMBL | 196 | 8 | 1 | 2 | 2.5 | CCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| 25190258 | 160605 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 419 | 10 | 1 | 5 | 3.4 | CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4079248 | 160605 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 419 | 10 | 1 | 5 | 3.4 | CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117327 | 160605 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 419 | 10 | 1 | 5 | 3.4 | CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 11791817 | 97851 | 0 | None | -1 | 2 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL274831 | 97851 | 0 | None | -1 | 2 | Guinea pig | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 71449250 | 80061 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146804 | 80061 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 57780007 | 146458 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 572 | 13 | 1 | 6 | 5.8 | CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3926412 | 146458 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 572 | 13 | 1 | 6 | 5.8 | CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 25190254 | 160556 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4068414 | 160556 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117012 | 160556 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 432 | 10 | 0 | 5 | 4.6 | CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 10042467 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 1203 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| CHEMBL11553 | 1398 | 1 | None | -1 | 2 | Guinea pig | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 10.1021/jm991056a | ||
| 57390224 | 67535 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 503 | 8 | 1 | 5 | 4.7 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910379 | 67535 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 503 | 8 | 1 | 5 | 4.7 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 44457702 | 82756 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 728 | 17 | 3 | 9 | 7.3 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21833 | 82756 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 728 | 17 | 3 | 9 | 7.3 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 25149712 | 178408 | 0 | None | - | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 299 | 7 | 4 | 3 | 1.6 | N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1 | 10.1021/jm800841w | ||
| CHEMBL470790 | 178408 | 0 | None | - | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 299 | 7 | 4 | 3 | 1.6 | N=C(NCCCc1c[nH]cn1)NC(=O)CCc1ccccc1 | 10.1021/jm800841w | ||
| 11956130 | 185383 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 319 | 7 | 4 | 3 | 2.6 | CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1021/jm800841w | ||
| CHEMBL486965 | 185383 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 319 | 7 | 4 | 3 | 2.6 | CC(CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1021/jm800841w | ||
| 1221 | 472 | 9 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm00128a045 | ||
| 65895 | 472 | 9 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm00128a045 | ||
| CHEMBL293802 | 472 | 9 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm00128a045 | ||
| 1221 | 472 | 9 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm800841w | ||
| 65895 | 472 | 9 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm800841w | ||
| CHEMBL293802 | 472 | 9 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm800841w | ||
| 19762580 | 80381 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 342 | 11 | 1 | 5 | 2.8 | COc1ccc(CN(CCN(C)CCCCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21520 | 80381 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 342 | 11 | 1 | 5 | 2.8 | COc1ccc(CN(CCN(C)CCCCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 15179508 | 202989 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 588 | 11 | 3 | 5 | 3.5 | N#CN/C(=N\CCNC(=O)c1cccc(I)c1)NCCCOc1cccc(CN2CCCCC2)c1 | 10.1021/jm00090a013 | ||
| CHEMBL73994 | 202989 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 588 | 11 | 3 | 5 | 3.5 | N#CN/C(=N\CCNC(=O)c1cccc(I)c1)NCCCOc1cccc(CN2CCCCC2)c1 | 10.1021/jm00090a013 | ||
| 14660391 | 197375 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 272 | 5 | 3 | 2 | 2.2 | N=C(N)NCCC(c1ccc(F)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL58620 | 197375 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 272 | 5 | 3 | 2 | 2.2 | N=C(N)NCCC(c1ccc(F)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 25149429 | 185382 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 305 | 6 | 4 | 3 | 2.2 | CC(C(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1021/jm800841w | ||
| CHEMBL486964 | 185382 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 305 | 6 | 4 | 3 | 2.2 | CC(C(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1021/jm800841w | ||
| 25149814 | 184742 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 291 | 6 | 4 | 3 | 2.0 | N=C(NCCCc1c[nH]cn1)NC(=O)CC1CCCCC1 | 10.1021/jm800841w | ||
| CHEMBL485958 | 184742 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 291 | 6 | 4 | 3 | 2.0 | N=C(NCCCc1c[nH]cn1)NC(=O)CC1CCCCC1 | 10.1021/jm800841w | ||
| 10022429 | 162239 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 376 | 10 | 4 | 3 | 3.5 | N=C(NCCCc1c[nH]cn1)NCCCC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL417221 | 162239 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 376 | 10 | 4 | 3 | 3.5 | N=C(NCCCc1c[nH]cn1)NCCCC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 11276413 | 11966 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 236 | 7 | 1 | 2 | 3.3 | c1nc(CCCOCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL1183700 | 11966 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 236 | 7 | 1 | 2 | 3.3 | c1nc(CCCOCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL313803 | 11966 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 236 | 7 | 1 | 2 | 3.3 | c1nc(CCCOCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| 54710792 | 125896 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 429 | 5 | 1 | 7 | 3.4 | O=c1oc2cc(CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| CHEMBL36517 | 125896 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 429 | 5 | 1 | 7 | 3.4 | O=c1oc2cc(CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| 2861271 | 4189 | 8 | None | - | 1 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL100486 | 4189 | 8 | None | - | 1 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1ccc(Cl)cc1 | 10.1021/jm00093a025 | ||
| 10729993 | 11303 | 1 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 259 | 6 | 2 | 4 | 2.6 | C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL114085 | 11303 | 1 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 259 | 6 | 2 | 4 | 2.6 | C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1180120 | 11303 | 1 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 259 | 6 | 2 | 4 | 2.6 | C/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 10492497 | 12268 | 0 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 273 | 7 | 2 | 4 | 3.0 | CC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1185539 | 12268 | 0 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 273 | 7 | 2 | 4 | 3.0 | CC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL420124 | 12268 | 0 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 273 | 7 | 2 | 4 | 3.0 | CC/C(=N\O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 44274554 | 82880 | 0 | None | - | 0 | Guinea pig | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 726 | 17 | 4 | 9 | 7.3 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=N)cc-4oc4cc(N)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21898 | 82880 | 0 | None | - | 0 | Guinea pig | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 726 | 17 | 4 | 9 | 7.3 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=N)cc-4oc4cc(N)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 44457689 | 93715 | 0 | None | - | 0 | Guinea pig | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 728 | 17 | 3 | 9 | 7.3 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL24940 | 93715 | 0 | None | - | 0 | Guinea pig | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 728 | 17 | 3 | 9 | 7.3 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 14660350 | 197762 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 392 | 10 | 3 | 4 | 2.9 | COc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1021/jm00128a045 | ||
| CHEMBL59138 | 197762 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 392 | 10 | 3 | 4 | 2.9 | COc1ccc(C(CC/N=C(\N)NCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1021/jm00128a045 | ||
| 164435 | 202837 | 29 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 477 | 11 | 4 | 6 | 2.5 | N#CN/C(=N\CCNC(=O)c1ccc(N)cc1)NCCCOc1cccc(CN2CCCCC2)c1 | 10.1021/jm00090a013 | ||
| CHEMBL72844 | 202837 | 29 | None | - | 0 | Guinea pig | 4.6 | pKd | = | 4.6 | Functional | ChEMBL | 477 | 11 | 4 | 6 | 2.5 | N#CN/C(=N\CCNC(=O)c1ccc(N)cc1)NCCCOc1cccc(CN2CCCCC2)c1 | 10.1021/jm00090a013 | ||
| 3081064 | 198751 | 11 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 398 | 9 | 4 | 3 | 3.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1cc(F)cc(F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL59832 | 198751 | 11 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 398 | 9 | 4 | 3 | 3.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1cc(F)cc(F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 14660355 | 100079 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(C(F)(F)F)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL291396 | 100079 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(C(F)(F)F)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 14660372 | 197552 | 0 | None | - | 0 | Guinea pig | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccc(Cl)cc1Cl | 10.1021/jm00128a045 | ||
| CHEMBL58999 | 197552 | 0 | None | - | 0 | Guinea pig | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccc(Cl)cc1Cl | 10.1021/jm00128a045 | ||
| 11741669 | 96305 | 0 | None | 39 | 2 | Guinea pig | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL264491 | 96305 | 0 | None | 39 | 2 | Guinea pig | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11269875 | 120491 | 0 | None | - | 1 | Guinea pig | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL356449 | 120491 | 0 | None | - | 1 | Guinea pig | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 44274585 | 81890 | 0 | None | - | 0 | Guinea pig | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 756 | 19 | 3 | 9 | 8.1 | COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21721 | 81890 | 0 | None | - | 0 | Guinea pig | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 756 | 19 | 3 | 9 | 8.1 | COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 25190134 | 160597 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 404 | 9 | 0 | 5 | 3.9 | CCCCc1cc(OC2CCN(CCS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4085417 | 160597 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 404 | 9 | 0 | 5 | 3.9 | CCCCc1cc(OC2CCN(CCS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| CHEMBL4117296 | 160597 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 404 | 9 | 0 | 5 | 3.9 | CCCCc1cc(OC2CCN(CCS(=O)(=O)CC)CC2)c2ncccc2c1 | 10.1016/j.bmcl.2017.09.020 | ||
| 2247 | 502 | 77 | None | - | 34 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| 249 | 502 | 77 | None | - | 34 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| 2603 | 502 | 77 | None | - | 34 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL296419 | 502 | 77 | None | - | 34 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| DB00637 | 502 | 77 | None | - | 34 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| 57393730 | 67542 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 579 | 8 | 2 | 6 | 5.0 | O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910386 | 67542 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 579 | 8 | 2 | 6 | 5.0 | O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2011.09.001 | ||
| 71456361 | 80069 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 369 | 4 | 0 | 6 | 2.5 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146812 | 80069 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 369 | 4 | 0 | 6 | 2.5 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 24803639 | 61002 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 622 | 14 | 1 | 7 | 6.8 | O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767166 | 61002 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 622 | 14 | 1 | 7 | 6.8 | O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 13676696 | 163521 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 467 | 7 | 1 | 8 | 4.0 | Cc1c(OCCCN2CCN(Cc3cccc(Cl)c3)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| CHEMBL420934 | 163521 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 467 | 7 | 1 | 8 | 4.0 | Cc1c(OCCCN2CCN(Cc3cccc(Cl)c3)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| 13676697 | 203086 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 467 | 7 | 1 | 8 | 4.0 | Cc1c(OCCCN2CCN(Cc3ccccc3Cl)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| CHEMBL74989 | 203086 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 467 | 7 | 1 | 8 | 4.0 | Cc1c(OCCCN2CCN(Cc3ccccc3Cl)CC2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| 54710795 | 99435 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 531 | 10 | 2 | 9 | 3.6 | CCCc1c(OCC(O)CN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c([N+](=O)[O-])c(=O)oc12 | 10.1021/jm00377a013 | ||
| CHEMBL286017 | 99435 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 531 | 10 | 2 | 9 | 3.6 | CCCc1c(OCC(O)CN2CCN(Cc3ccc(Cl)cc3)CC2)ccc2c(O)c([N+](=O)[O-])c(=O)oc12 | 10.1021/jm00377a013 | ||
| 42625223 | 179345 | 0 | None | - | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 395 | 8 | 4 | 3 | 1.4 | CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1 | 10.1021/jm9000693 | ||
| CHEMBL474617 | 179345 | 0 | None | - | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 395 | 8 | 4 | 3 | 1.4 | CN(CCC(=O)/N=C(\N)NCCCc1c[nH]cn1)C(=O)c1cc2ccccc2[nH]1 | 10.1021/jm9000693 | ||
| 44274584 | 80272 | 0 | None | - | 0 | Guinea pig | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 700 | 15 | 3 | 9 | 6.5 | COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21514 | 80272 | 0 | None | - | 0 | Guinea pig | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 700 | 15 | 3 | 9 | 6.5 | COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 44274555 | 76655 | 0 | None | - | 0 | Guinea pig | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 782 | 18 | 1 | 9 | 6.0 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=[N+](C)C)cc-4oc4cc(N(C)C)ccc34)c(C(=O)[O-])c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL20713 | 76655 | 0 | None | - | 0 | Guinea pig | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 782 | 18 | 1 | 9 | 6.0 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc(=[N+](C)C)cc-4oc4cc(N(C)C)ccc34)c(C(=O)[O-])c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 14660378 | 100180 | 0 | None | - | 0 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 348 | 8 | 4 | 3 | 2.7 | N=C(NCCCc1c[nH]cn1)NCC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL292170 | 100180 | 0 | None | - | 0 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 348 | 8 | 4 | 3 | 2.7 | N=C(NCCCc1c[nH]cn1)NCC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 1226 | 1988 | 16 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 321 | 9 | 4 | 4 | 1.2 | NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C | 10.1021/jm800841w | ||
| 41376 | 1988 | 16 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 321 | 9 | 4 | 4 | 1.2 | NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C | 10.1021/jm800841w | ||
| CHEMBL12608 | 1988 | 16 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 321 | 9 | 4 | 4 | 1.2 | NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C | 10.1021/jm800841w | ||
| 14660384 | 201045 | 0 | None | - | 0 | Guinea pig | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 379 | 9 | 4 | 2 | 3.8 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(F)cc1 | 10.1021/jm00128a045 | ||
| CHEMBL61852 | 201045 | 0 | None | - | 0 | Guinea pig | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 379 | 9 | 4 | 2 | 3.8 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(F)cc1 | 10.1021/jm00128a045 | ||
| 14660395 | 201093 | 0 | None | - | 0 | Guinea pig | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 378 | 8 | 4 | 3 | 3.1 | N=C(NC/C=C(\c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| CHEMBL62147 | 201093 | 0 | None | - | 0 | Guinea pig | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 378 | 8 | 4 | 3 | 3.1 | N=C(NC/C=C(\c1ccc(F)cc1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| 42625386 | 177778 | 0 | None | - | 4 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 237 | 6 | 3 | 2 | 0.6 | CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL465170 | 177778 | 0 | None | - | 4 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 237 | 6 | 3 | 2 | 0.6 | CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 44274553 | 81987 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 828 | 17 | 3 | 9 | 9.7 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc5cc(O)ccc5c4oc4c3ccc3cc(=O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21727 | 81987 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 828 | 17 | 3 | 9 | 9.7 | COc1ccc(CN(CCN(C)CCCCCCNC(=O)c2ccc(-c3c4ccc5cc(O)ccc5c4oc4c3ccc3cc(=O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 14660382 | 196983 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccncc1)c1ccc(F)cc1 | 10.1021/jm00128a045 | ||
| CHEMBL57933 | 196983 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccncc1)c1ccc(F)cc1 | 10.1021/jm00128a045 | ||
| 1199 | 2928 | 0 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 394 | 8 | 3 | 4 | 2.5 | NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm800841w | ||
| 25149244 | 2928 | 0 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 394 | 8 | 3 | 4 | 2.5 | NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm800841w | ||
| CHEMBL472273 | 2928 | 0 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 394 | 8 | 3 | 4 | 2.5 | NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F | 10.1021/jm800841w | ||
| 42626109 | 179188 | 0 | None | - | 2 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 324 | 6 | 4 | 2 | 1.5 | N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL474447 | 179188 | 0 | None | - | 2 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 324 | 6 | 4 | 2 | 1.5 | N/C(=N\C(=O)Cc1c[nH]c2ccccc12)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 14660376 | 200881 | 0 | None | - | 0 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 363 | 9 | 4 | 4 | 2.5 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL61185 | 200881 | 0 | None | - | 0 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 363 | 9 | 4 | 4 | 2.5 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 2861590 | 106776 | 7 | None | - | 1 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202937 | 106776 | 7 | None | - | 1 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL316951 | 106776 | 7 | None | - | 1 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1ccc(Br)cc1 | 10.1021/jm00093a025 | ||
| 126624 | 206549 | 9 | None | - | 1 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 264 | 5 | 0 | 3 | 2.2 | CN(C)CCCN1C(=O)CSC1c1ccccc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202936 | 206549 | 9 | None | - | 1 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 264 | 5 | 0 | 3 | 2.2 | CN(C)CCCN1C(=O)CSC1c1ccccc1 | 10.1021/jm00093a025 | ||
| CHEMBL98989 | 206549 | 9 | None | - | 1 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 264 | 5 | 0 | 3 | 2.2 | CN(C)CCCN1C(=O)CSC1c1ccccc1 | 10.1021/jm00093a025 | ||
| 42625221 | 188997 | 0 | None | - | 2 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 338 | 7 | 4 | 2 | 1.9 | N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL514641 | 188997 | 0 | None | - | 2 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 338 | 7 | 4 | 2 | 1.9 | N/C(=N\C(=O)CCc1c[nH]c2ccccc12)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 14984033 | 206437 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202941 | 206437 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| CHEMBL98334 | 206437 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 294 | 6 | 0 | 4 | 2.2 | COc1cccc(C2SCC(=O)N2CCCN(C)C)c1 | 10.1021/jm00093a025 | ||
| 14984032 | 206600 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202932 | 206600 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1 | 10.1021/jm00093a025 | ||
| CHEMBL99350 | 206600 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 342 | 5 | 0 | 3 | 3.0 | CN(C)CCCN1C(=O)CSC1c1cccc(Br)c1 | 10.1021/jm00093a025 | ||
| 14984031 | 206632 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1cccc(F)c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202933 | 206632 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1cccc(F)c1 | 10.1021/jm00093a025 | ||
| CHEMBL99529 | 206632 | 1 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1cccc(F)c1 | 10.1021/jm00093a025 | ||
| 2861786 | 206436 | 8 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 309 | 6 | 0 | 5 | 2.1 | CN(C)CCCN1C(=O)CSC1c1cccc([N+](=O)[O-])c1 | 10.1021/jm00093a025 | ||
| CHEMBL1202940 | 206436 | 8 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 309 | 6 | 0 | 5 | 2.1 | CN(C)CCCN1C(=O)CSC1c1cccc([N+](=O)[O-])c1 | 10.1021/jm00093a025 | ||
| CHEMBL98333 | 206436 | 8 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 309 | 6 | 0 | 5 | 2.1 | CN(C)CCCN1C(=O)CSC1c1cccc([N+](=O)[O-])c1 | 10.1021/jm00093a025 | ||
| 10364258 | 45512 | 0 | None | 12 | 2 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153067 | 45512 | 0 | None | 12 | 2 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 44274569 | 80429 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 700 | 15 | 3 | 9 | 6.5 | COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21525 | 80429 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 700 | 15 | 3 | 9 | 6.5 | COc1ccc(CN(CCN(C)CCCCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 44274548 | 98729 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 477 | 12 | 1 | 10 | 3.6 | COc1ccc(CN(CCN(C)CCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL281365 | 98729 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 477 | 12 | 1 | 10 | 3.6 | COc1ccc(CN(CCN(C)CCNc2ccc([N+](=O)[O-])c3nonc23)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 57402472 | 67537 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 526 | 11 | 1 | 6 | 4.0 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910381 | 67537 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 526 | 11 | 1 | 6 | 4.0 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 1200 | 3900 | 1 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 335 | 8 | 4 | 5 | 0.7 | O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C | 10.1021/jm800841w | ||
| 25149519 | 3900 | 1 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 335 | 8 | 4 | 5 | 0.7 | O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C | 10.1021/jm800841w | ||
| CHEMBL513056 | 3900 | 1 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 335 | 8 | 4 | 5 | 0.7 | O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C | 10.1021/jm800841w | ||
| 14660370 | 162694 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1cc(Cl)cc(Cl)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL418508 | 162694 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1cc(Cl)cc(Cl)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 14660363 | 200991 | 0 | None | - | 0 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1F | 10.1021/jm00128a045 | ||
| CHEMBL61523 | 200991 | 0 | None | - | 0 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 380 | 9 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1F | 10.1021/jm00128a045 | ||
| 14660411 | 198032 | 0 | None | - | 0 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 368 | 9 | 4 | 4 | 3.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1cccs1 | 10.1021/jm00128a045 | ||
| CHEMBL59339 | 198032 | 0 | None | - | 0 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 368 | 9 | 4 | 4 | 3.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1cccs1 | 10.1021/jm00128a045 | ||
| 14660345 | 197415 | 0 | None | - | 0 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 394 | 10 | 4 | 3 | 3.6 | N=C(NCCCc1c[nH]cn1)NCCCC(c1ccc(F)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL58869 | 197415 | 0 | None | - | 0 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 394 | 10 | 4 | 3 | 3.6 | N=C(NCCCc1c[nH]cn1)NCCCC(c1ccc(F)cc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 25149613 | 178621 | 0 | None | - | 2 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 382 | 8 | 4 | 5 | 2.7 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1 | 10.1021/jm800841w | ||
| CHEMBL472441 | 178621 | 0 | None | - | 2 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 382 | 8 | 4 | 5 | 2.7 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1nccs1 | 10.1021/jm800841w | ||
| 25149246 | 188886 | 0 | None | - | 0 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 418 | 8 | 4 | 5 | 2.9 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccc(F)c(F)c1)c1nccs1 | 10.1021/jm800841w | ||
| CHEMBL513755 | 188886 | 0 | None | - | 0 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 418 | 8 | 4 | 5 | 2.9 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccc(F)c(F)c1)c1nccs1 | 10.1021/jm800841w | ||
| 54587323 | 62786 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Functional | ChEMBL | 277 | 7 | 2 | 3 | 3.0 | O=C(NCCC1=CCCCC1)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1774596 | 62786 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Functional | ChEMBL | 277 | 7 | 2 | 3 | 3.0 | O=C(NCCC1=CCCCC1)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1789341 | 62786 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Functional | ChEMBL | 277 | 7 | 2 | 3 | 3.0 | O=C(NCCC1=CCCCC1)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| 134136763 | 142316 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 500 | 11 | 0 | 5 | 6.0 | c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3893197 | 142316 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 500 | 11 | 0 | 5 | 6.0 | c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 54710793 | 108334 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 489 | 8 | 2 | 9 | 2.6 | O=c1oc2cc(OCC(O)CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| CHEMBL32097 | 108334 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 489 | 8 | 2 | 9 | 2.6 | O=c1oc2cc(OCC(O)CN3CCN(Cc4ccc(Cl)cc4)CC3)ccc2c(O)c1[N+](=O)[O-] | 10.1021/jm00377a013 | ||
| 44274583 | 98274 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 756 | 19 | 3 | 9 | 8.1 | COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL277850 | 98274 | 0 | None | - | 0 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 756 | 19 | 3 | 9 | 8.1 | COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 4440380 | 4190 | 3 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL100487 | 4190 | 3 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202938 | 4190 | 3 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 278 | 5 | 0 | 3 | 2.5 | Cc1ccc(C2SCC(=O)N2CCCN(C)C)cc1 | 10.1021/jm00093a025 | ||
| 11791817 | 97851 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| CHEMBL274831 | 97851 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 345 | 9 | 2 | 2 | 4.5 | c1ccc(C(CCc2nc(CCNC3CC3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm991056a | ||
| 10083274 | 11289 | 0 | None | - | 0 | Guinea pig | 4.3 | pKd | = | 4.3 | Functional | ChEMBL | 246 | 6 | 2 | 3 | 2.5 | CC(O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL112676 | 11289 | 0 | None | - | 0 | Guinea pig | 4.3 | pKd | = | 4.3 | Functional | ChEMBL | 246 | 6 | 2 | 3 | 2.5 | CC(O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1180069 | 11289 | 0 | None | - | 0 | Guinea pig | 4.3 | pKd | = | 4.3 | Functional | ChEMBL | 246 | 6 | 2 | 3 | 2.5 | CC(O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 14660365 | 198304 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 396 | 9 | 4 | 3 | 3.7 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1Cl | 10.1021/jm00128a045 | ||
| CHEMBL59521 | 198304 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 396 | 9 | 4 | 3 | 3.7 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccn1)c1ccccc1Cl | 10.1021/jm00128a045 | ||
| 42625303 | 180184 | 0 | None | - | 6 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 223 | 5 | 3 | 2 | 0.2 | CCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL475621 | 180184 | 0 | None | - | 6 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 223 | 5 | 3 | 2 | 0.2 | CCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 25149431 | 184855 | 0 | None | - | 0 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 277 | 5 | 4 | 3 | 1.6 | N=C(NCCCc1c[nH]cn1)NC(=O)C1CCCCC1 | 10.1021/jm800841w | ||
| CHEMBL486153 | 184855 | 0 | None | - | 0 | Guinea pig | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 277 | 5 | 4 | 3 | 1.6 | N=C(NCCCc1c[nH]cn1)NC(=O)C1CCCCC1 | 10.1021/jm800841w | ||
| 14660361 | 199817 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(C(F)(F)F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL60515 | 199817 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(C(F)(F)F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 25149811 | 185380 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 327 | 9 | 4 | 3 | 2.4 | N=C(NCCCc1c[nH]cn1)NC(=O)CCCCc1ccccc1 | 10.1021/jm800841w | ||
| CHEMBL486963 | 185380 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 327 | 9 | 4 | 3 | 2.4 | N=C(NCCCc1c[nH]cn1)NC(=O)CCCCc1ccccc1 | 10.1021/jm800841w | ||
| 25149425 | 187623 | 0 | None | - | 0 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 285 | 6 | 4 | 3 | 1.2 | N=C(NCCCc1c[nH]cn1)NC(=O)Cc1ccccc1 | 10.1021/jm800841w | ||
| CHEMBL499092 | 187623 | 0 | None | - | 0 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 285 | 6 | 4 | 3 | 1.2 | N=C(NCCCc1c[nH]cn1)NC(=O)Cc1ccccc1 | 10.1021/jm800841w | ||
| 10410901 | 119242 | 0 | None | -23 | 2 | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL347796 | 119242 | 0 | None | -23 | 2 | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 23582308 | 145331 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 634 | 14 | 1 | 6 | 6.9 | O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3917428 | 145331 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 634 | 14 | 1 | 6 | 6.9 | O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| 153224 | 201139 | 24 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 271 | 7 | 1 | 4 | 2.3 | CNCCN(Cc1ccc(OC)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL624 | 201139 | 24 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 271 | 7 | 1 | 4 | 2.3 | CNCCN(Cc1ccc(OC)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00113-6 | ||
| 25149433 | 185394 | 2 | None | - | 0 | Guinea pig | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 305 | 7 | 4 | 3 | 2.3 | N=C(NCCCc1c[nH]cn1)NC(=O)CCC1CCCCC1 | 10.1021/jm800841w | ||
| CHEMBL486974 | 185394 | 2 | None | - | 0 | Guinea pig | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 305 | 7 | 4 | 3 | 2.3 | N=C(NCCCc1c[nH]cn1)NC(=O)CCC1CCCCC1 | 10.1021/jm800841w | ||
| 13676693 | 102527 | 0 | None | - | 0 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 463 | 8 | 1 | 9 | 3.3 | COc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1 | 10.1021/jm00161a022 | ||
| CHEMBL306807 | 102527 | 0 | None | - | 0 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 463 | 8 | 1 | 9 | 3.3 | COc1ccc(CN2CCN(CCCOc3ccc4c(O)c5nnnc-5oc4c3C)CC2)cc1 | 10.1021/jm00161a022 | ||
| 2860026 | 107890 | 6 | None | - | 1 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1 | 10.1021/jm00093a025 | ||
| CHEMBL319829 | 107890 | 6 | None | - | 1 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 298 | 5 | 0 | 3 | 2.9 | CN(C)CCCN1C(=O)CSC1c1cccc(Cl)c1 | 10.1021/jm00093a025 | ||
| 2861042 | 111094 | 8 | None | - | 0 | Guinea pig | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 309 | 6 | 0 | 5 | 2.1 | CN(C)CCCN1C(=O)CSC1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202943 | 111094 | 8 | None | - | 0 | Guinea pig | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 309 | 6 | 0 | 5 | 2.1 | CN(C)CCCN1C(=O)CSC1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00093a025 | ||
| CHEMBL328201 | 111094 | 8 | None | - | 0 | Guinea pig | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | 309 | 6 | 0 | 5 | 2.1 | CN(C)CCCN1C(=O)CSC1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm00093a025 | ||
| 11356502 | 11233 | 0 | None | - | 0 | Guinea pig | 4.2 | pKd | = | 4.2 | Functional | ChEMBL | 222 | 6 | 1 | 2 | 3.3 | c1nc(COCCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL1179596 | 11233 | 0 | None | - | 0 | Guinea pig | 4.2 | pKd | = | 4.2 | Functional | ChEMBL | 222 | 6 | 1 | 2 | 3.3 | c1nc(COCCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL88362 | 11233 | 0 | None | - | 0 | Guinea pig | 4.2 | pKd | = | 4.2 | Functional | ChEMBL | 222 | 6 | 1 | 2 | 3.3 | c1nc(COCCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| 14660412 | 200520 | 0 | None | - | 0 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 378 | 9 | 4 | 4 | 2.6 | N/C(=N\CCC(c1ccc(O)cc1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| CHEMBL60972 | 200520 | 0 | None | - | 0 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 378 | 9 | 4 | 4 | 2.6 | N/C(=N\CCC(c1ccc(O)cc1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| 44457674 | 83894 | 0 | None | - | 0 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 672 | 13 | 3 | 9 | 5.7 | COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL22152 | 83894 | 0 | None | - | 0 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 672 | 13 | 3 | 9 | 5.7 | COc1ccc(CN(CCN(C)CCNC(=O)c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 57391869 | 62790 | 0 | None | - | 1 | Guinea pig | 4.2 | pKd | = | 4.2 | Functional | ChEMBL | 223 | 6 | 2 | 3 | 1.6 | CC=CCNC(=O)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1774589 | 62790 | 0 | None | - | 1 | Guinea pig | 4.2 | pKd | = | 4.2 | Functional | ChEMBL | 223 | 6 | 2 | 3 | 1.6 | CC=CCNC(=O)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1789349 | 62790 | 0 | None | - | 1 | Guinea pig | 4.2 | pKd | = | 4.2 | Functional | ChEMBL | 223 | 6 | 2 | 3 | 1.6 | CC=CCNC(=O)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| 57400700 | 67536 | 0 | None | - | 0 | Guinea pig | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 470 | 8 | 1 | 6 | 3.4 | COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910380 | 67536 | 0 | None | - | 0 | Guinea pig | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 470 | 8 | 1 | 6 | 3.4 | COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 57397301 | 67538 | 0 | None | - | 0 | Guinea pig | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 560 | 11 | 1 | 6 | 4.6 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910382 | 67538 | 0 | None | - | 0 | Guinea pig | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 560 | 11 | 1 | 6 | 4.6 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 145961372 | 161059 | 0 | None | - | 1 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 311 | 7 | 0 | 2 | 5.3 | c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1 | 10.1016/j.bmc.2018.04.023 | ||
| CHEMBL4129589 | 161059 | 0 | None | - | 1 | Guinea pig | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 311 | 7 | 0 | 2 | 5.3 | c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1 | 10.1016/j.bmc.2018.04.023 | ||
| 2200 | 20003 | 57 | None | - | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2018.04.023 | ||
| CHEMBL1256819 | 20003 | 57 | None | - | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2018.04.023 | ||
| CHEMBL1305 | 20003 | 57 | None | - | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2018.04.023 | ||
| 42625224 | 180182 | 0 | None | - | 1 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 395 | 9 | 5 | 3 | 1.5 | N/C(=N\C(=O)CCCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL475620 | 180182 | 0 | None | - | 1 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 395 | 9 | 5 | 3 | 1.5 | N/C(=N\C(=O)CCCNC(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 25149521 | 178474 | 0 | None | - | 2 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 375 | 8 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1 | 10.1021/jm800841w | ||
| CHEMBL471413 | 178474 | 0 | None | - | 2 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 375 | 8 | 4 | 3 | 3.2 | N=C(NCCCc1c[nH]cn1)NC(=O)CC(c1ccccc1)c1ccccc1 | 10.1021/jm800841w | ||
| 25149515 | 185248 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 319 | 8 | 4 | 3 | 2.7 | N=C(NCCCc1c[nH]cn1)NC(=O)CCCC1CCCCC1 | 10.1021/jm800841w | ||
| CHEMBL486746 | 185248 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 319 | 8 | 4 | 3 | 2.7 | N=C(NCCCc1c[nH]cn1)NC(=O)CCCC1CCCCC1 | 10.1021/jm800841w | ||
| 1219 | 727 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 396 | 9 | 3 | 3 | 3.5 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl | 10.1021/jm00128a045 | ||
| 14660352 | 727 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 396 | 9 | 3 | 3 | 3.5 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl | 10.1021/jm00128a045 | ||
| CHEMBL304239 | 727 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 396 | 9 | 3 | 3 | 3.5 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl | 10.1021/jm00128a045 | ||
| 42625304 | 178522 | 0 | None | - | 4 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 237 | 5 | 3 | 2 | 0.4 | CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL471724 | 178522 | 0 | None | - | 4 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 237 | 5 | 3 | 2 | 0.4 | CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 10094258 | 197392 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Cl)c(Cl)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL58740 | 197392 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 430 | 9 | 4 | 3 | 4.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(Cl)c(Cl)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 13676703 | 202899 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 1 | 8 | 4.2 | Cc1c(OCCCN(C)CCN(C)Cc2ccc(Cl)cc2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| CHEMBL73265 | 202899 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 1 | 8 | 4.2 | Cc1c(OCCCN(C)CCN(C)Cc2ccc(Cl)cc2)ccc2c(O)c3nnnc-3oc12 | 10.1021/jm00161a022 | ||
| 2872050 | 206485 | 3 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL1202939 | 206485 | 3 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1 | 10.1021/jm00093a025 | ||
| CHEMBL98605 | 206485 | 3 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 282 | 5 | 0 | 3 | 2.4 | CN(C)CCCN1C(=O)CSC1c1ccc(F)cc1 | 10.1021/jm00093a025 | ||
| 11345716 | 11239 | 0 | None | - | 0 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 250 | 8 | 1 | 2 | 3.7 | c1nc(CCCOCCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL1179627 | 11239 | 0 | None | - | 0 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 250 | 8 | 1 | 2 | 3.7 | c1nc(CCCOCCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| CHEMBL89999 | 11239 | 0 | None | - | 0 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 250 | 8 | 1 | 2 | 3.7 | c1nc(CCCOCCCC2CCCCC2)c[nH]1 | 10.1021/jm031065q | ||
| 11413171 | 12004 | 0 | None | - | 1 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 210 | 9 | 1 | 2 | 2.9 | CCCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| CHEMBL1184057 | 12004 | 0 | None | - | 1 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 210 | 9 | 1 | 2 | 2.9 | CCCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| CHEMBL330688 | 12004 | 0 | None | - | 1 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 210 | 9 | 1 | 2 | 2.9 | CCCCCCOCCCc1c[nH]cn1 | 10.1021/jm031065q | ||
| 54584376 | 62838 | 0 | None | - | 1 | Guinea pig | 4.1 | pKd | = | 4.1 | Functional | ChEMBL | 237 | 7 | 2 | 3 | 2.0 | CC/C=C\CNC(=O)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1774592 | 62838 | 0 | None | - | 1 | Guinea pig | 4.1 | pKd | = | 4.1 | Functional | ChEMBL | 237 | 7 | 2 | 3 | 2.0 | CC/C=C\CNC(=O)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| CHEMBL1789809 | 62838 | 0 | None | - | 1 | Guinea pig | 4.1 | pKd | = | 4.1 | Functional | ChEMBL | 237 | 7 | 2 | 3 | 2.0 | CC/C=C\CNC(=O)OCCCc1c[nH]cn1 | 10.1016/j.bmc.2011.03.046 | ||
| 10635074 | 11299 | 0 | None | - | 0 | Guinea pig | 4.1 | pKd | = | 4.1 | Functional | ChEMBL | 260 | 6 | 3 | 4 | 1.0 | NNC(=O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL113404 | 11299 | 0 | None | - | 0 | Guinea pig | 4.1 | pKd | = | 4.1 | Functional | ChEMBL | 260 | 6 | 3 | 4 | 1.0 | NNC(=O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| CHEMBL1180094 | 11299 | 0 | None | - | 0 | Guinea pig | 4.1 | pKd | = | 4.1 | Functional | ChEMBL | 260 | 6 | 3 | 4 | 1.0 | NNC(=O)c1ccc(OCCCc2c[nH]cn2)cc1 | 10.1021/jm000971p | ||
| 57390225 | 67540 | 0 | None | - | 0 | Guinea pig | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 469 | 9 | 2 | 5 | 4.1 | COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910384 | 67540 | 0 | None | - | 0 | Guinea pig | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 469 | 9 | 2 | 5 | 4.1 | COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 10246247 | 97841 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.5 | NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| CHEMBL274767 | 97841 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 333 | 9 | 2 | 2 | 4.5 | NCCc1c[nH]c(CCCCC(c2ccccc2)c2ccccc2)n1 | 10.1021/jm991056a | ||
| 3081063 | 199824 | 16 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 398 | 9 | 4 | 3 | 3.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)c(F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL60519 | 199824 | 16 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 398 | 9 | 4 | 3 | 3.4 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccc(F)c(F)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 14660416 | 199045 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 377 | 9 | 4 | 4 | 2.4 | N/C(=N\CCC(c1cccc(N)c1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| CHEMBL60006 | 199045 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 377 | 9 | 4 | 4 | 2.4 | N/C(=N\CCC(c1cccc(N)c1)c1ccccn1)NCCCc1c[nH]cn1 | 10.1021/jm00128a045 | ||
| 42625384 | 169206 | 0 | None | - | 4 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 209 | 4 | 3 | 2 | -0.2 | CC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL443896 | 169206 | 0 | None | - | 4 | Guinea pig | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | 209 | 4 | 3 | 2 | -0.2 | CC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 14660359 | 197450 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 396 | 9 | 4 | 3 | 3.7 | N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(Cl)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL58922 | 197450 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 396 | 9 | 4 | 3 | 3.7 | N=C(NCCCc1c[nH]cn1)NCCC(c1cccc(Cl)c1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 10447834 | 1902 | 4 | None | -2 | 3 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 4026 | 1902 | 4 | None | -2 | 3 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275507 | 1902 | 4 | None | -2 | 3 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 10447834 | 1902 | 4 | None | -2 | 3 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 4026 | 1902 | 4 | None | -2 | 3 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275507 | 1902 | 4 | None | -2 | 3 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 11741669 | 96305 | 0 | None | -39 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL264491 | 96305 | 0 | None | -39 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10403687 | 2475 | 2 | None | -1 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 1205 | 2475 | 2 | None | -1 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| CHEMBL275035 | 2475 | 2 | None | -1 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm991056a | ||
| 10403687 | 2475 | 2 | None | -1 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1205 | 2475 | 2 | None | -1 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275035 | 2475 | 2 | None | -1 | 2 | Rat | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 44274460 | 81999 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 398 | 15 | 1 | 5 | 4.3 | COc1ccc(CN(CCN(C)CCCCCCCCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| CHEMBL21735 | 81999 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 398 | 15 | 1 | 5 | 4.3 | COc1ccc(CN(CCN(C)CCCCCCCCN)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00113-6 | ||
| 11726167 | 197976 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 362 | 9 | 4 | 3 | 3.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| CHEMBL59295 | 197976 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 362 | 9 | 4 | 3 | 3.1 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccccn1 | 10.1021/jm00128a045 | ||
| 14660386 | 201092 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 395 | 9 | 4 | 2 | 4.3 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)cc1 | 10.1021/jm00128a045 | ||
| CHEMBL62142 | 201092 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 395 | 9 | 4 | 2 | 4.3 | N=C(NCCCc1c[nH]cn1)NCCC(c1ccccc1)c1ccc(Cl)cc1 | 10.1021/jm00128a045 | ||
| 1201 | 3901 | 1 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 361 | 7 | 3 | 3 | 2.6 | O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N | 10.1021/jm800841w | ||
| 25150700 | 3901 | 1 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 361 | 7 | 3 | 3 | 2.6 | O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N | 10.1021/jm800841w | ||
| CHEMBL499301 | 3901 | 1 | None | - | 0 | Guinea pig | 5.0 | pKd | = | 5.0 | Functional | ChEMBL | 361 | 7 | 3 | 3 | 2.6 | O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N | 10.1021/jm800841w | ||
| 52937526 | 60973 | 0 | None | - | 0 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 363 | 5 | 0 | 5 | 3.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767137 | 60973 | 0 | None | - | 0 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 363 | 5 | 0 | 5 | 3.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| 1530 | 2151 | 44 | None | 2 | 21 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm100856p | ||
| 3827 | 2151 | 44 | None | 2 | 21 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm100856p | ||
| 7206 | 2151 | 44 | None | 2 | 21 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm100856p | ||
| CHEMBL534 | 2151 | 44 | None | 2 | 21 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm100856p | ||
| DB00920 | 2151 | 44 | None | 2 | 21 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm100856p | ||
| 15254720 | 60972 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767136 | 60972 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 52937527 | 60974 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 2.8 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(O)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767138 | 60974 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 2.8 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(O)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 15254720 | 60972 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL1767136 | 60972 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 52937631 | 60978 | 0 | None | - | 0 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 347 | 4 | 0 | 4 | 3.4 | Cc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767141 | 60978 | 0 | None | - | 0 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 347 | 4 | 0 | 4 | 3.4 | Cc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| 71452871 | 80058 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146801 | 80058 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 203096 | 60970 | 2 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 341 | 5 | 0 | 4 | 3.2 | CN(C)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767134 | 60970 | 2 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 341 | 5 | 0 | 4 | 3.2 | CN(C)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 52937732 | 60985 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 369 | 4 | 0 | 4 | 3.4 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)c(F)c2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767149 | 60985 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 369 | 4 | 0 | 4 | 3.4 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)c(F)c2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 71458204 | 80066 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146809 | 80066 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 52937630 | 60977 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 351 | 4 | 0 | 4 | 3.2 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767140 | 60977 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 351 | 4 | 0 | 4 | 3.2 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 52937830 | 60990 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767154 | 60990 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 71458203 | 80062 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146805 | 80062 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71452872 | 80024 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146484 | 80024 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71461782 | 80063 | 0 | None | - | 0 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146806 | 80063 | 0 | None | - | 0 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 46861860 | 7410 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 4.0 | CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1087089 | 7410 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 4.0 | CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 52937728 | 60981 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 351 | 4 | 0 | 4 | 3.2 | CN1CCC[C@@H]1Cn1nc(Cc2cccc(F)c2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767145 | 60981 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 351 | 4 | 0 | 4 | 3.2 | CN1CCC[C@@H]1Cn1nc(Cc2cccc(F)c2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 71456359 | 80060 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 411 | 7 | 0 | 5 | 3.8 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146803 | 80060 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 411 | 7 | 0 | 5 | 3.8 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71458205 | 80068 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146811 | 80068 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71451044 | 80064 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146807 | 80064 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 71454639 | 80067 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146810 | 80067 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 410 | 7 | 0 | 5 | 4.3 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 49864841 | 15555 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 266 | 1 | 1 | 4 | 1.6 | C1=C(N2CCNCC2)c2nccn2Cc2ccccc21 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222552 | 15555 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 266 | 1 | 1 | 4 | 1.6 | C1=C(N2CCNCC2)c2nccn2Cc2ccccc21 | 10.1016/j.bmcl.2010.07.029 | ||
| 71449250 | 80061 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146804 | 80061 | 0 | None | - | 0 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 368 | 4 | 0 | 5 | 3.1 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccncc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 52937731 | 60984 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 347 | 4 | 0 | 4 | 3.4 | Cc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1 | 10.1021/jm1013874 | ||
| CHEMBL1767148 | 60984 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 347 | 4 | 0 | 4 | 3.4 | Cc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1 | 10.1021/jm1013874 | ||
| 46861858 | 8477 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 335 | 5 | 0 | 4 | 3.9 | CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1094510 | 8477 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 335 | 5 | 0 | 4 | 3.9 | CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57402315 | 69369 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 311 | 3 | 1 | 4 | 2.9 | Fc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935442 | 69369 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 311 | 3 | 1 | 4 | 2.9 | Fc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 46888857 | 8624 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 4.0 | CN1CCC[C@@H](c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1095819 | 8624 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 323 | 3 | 0 | 3 | 4.0 | CN1CCC[C@@H](c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 71461781 | 80059 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 409 | 7 | 0 | 4 | 4.9 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146802 | 80059 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 409 | 7 | 0 | 4 | 4.9 | CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 57398830 | 69363 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 353 | 5 | 1 | 4 | 3.4 | OCCN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935436 | 69363 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 353 | 5 | 1 | 4 | 3.4 | OCCN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57400501 | 69365 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 3.6 | c1ccc(OCCn2c(C3CCCNC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935438 | 69365 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 3.6 | c1ccc(OCCn2c(C3CCCNC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57395287 | 69368 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 307 | 3 | 1 | 4 | 3.1 | Cc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935441 | 69368 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 307 | 3 | 1 | 4 | 3.1 | Cc1ccc(Cn2c([C@H]3CNCCO3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 71456360 | 80065 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146808 | 80065 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 412 | 7 | 0 | 6 | 3.1 | COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 52937222 | 60992 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 367 | 3 | 0 | 4 | 3.9 | CN1CCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1 | 10.1021/jm1013874 | ||
| CHEMBL1767156 | 60992 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 367 | 3 | 0 | 4 | 3.9 | CN1CCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1 | 10.1021/jm1013874 | ||
| 57404030 | 69364 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 309 | 3 | 1 | 3 | 3.7 | Fc1ccc(Cn2c([C@@H]3CCCNC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935437 | 69364 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 309 | 3 | 1 | 3 | 3.7 | Fc1ccc(Cn2c([C@@H]3CCCNC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmc.2012.08.032 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1016/j.bmcl.2016.11.022 | ||
| 2267 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| 271 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| 7121 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| CHEMBL639 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| DB00972 | 553 | 64 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 10.1021/jm1013874 | ||
| 71456361 | 80069 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 369 | 4 | 0 | 6 | 2.5 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146812 | 80069 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 369 | 4 | 0 | 6 | 2.5 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2nccnc2c1=O | 10.1016/j.bmc.2012.08.032 | ||
| 57400503 | 69371 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 323 | 3 | 1 | 4 | 3.8 | Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935444 | 69371 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 323 | 3 | 1 | 4 | 3.8 | Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57397056 | 69373 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 327 | 3 | 1 | 4 | 3.6 | Fc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935446 | 69373 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 327 | 3 | 1 | 4 | 3.6 | Fc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57400505 | 69374 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 339 | 4 | 1 | 5 | 3.5 | COc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935447 | 69374 | 0 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 339 | 4 | 1 | 5 | 3.5 | COc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57400503 | 69371 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 323 | 3 | 1 | 4 | 3.8 | Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935444 | 69371 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 323 | 3 | 1 | 4 | 3.8 | Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 52937729 | 60982 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2cccc(Cl)c2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767146 | 60982 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.7 | CN1CCC[C@@H]1Cn1nc(Cc2cccc(Cl)c2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 52937829 | 60989 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 313 | 6 | 0 | 4 | 3.2 | CCCCCc1nn(C[C@H]2CCCN2C)c(=O)c2ccccc12 | 10.1021/jm1013874 | ||
| CHEMBL1767153 | 60989 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 313 | 6 | 0 | 4 | 3.2 | CCCCCc1nn(C[C@H]2CCCN2C)c(=O)c2ccccc12 | 10.1021/jm1013874 | ||
| 57400502 | 69370 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 321 | 3 | 1 | 4 | 3.4 | Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935443 | 69370 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 321 | 3 | 1 | 4 | 3.4 | Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C | 10.1016/j.bmcl.2011.10.115 | ||
| 52937730 | 60983 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 363 | 5 | 0 | 5 | 3.1 | COc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1 | 10.1021/jm1013874 | ||
| CHEMBL1767147 | 60983 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 363 | 5 | 0 | 5 | 3.1 | COc1cccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)c1 | 10.1021/jm1013874 | ||
| 52945978 | 18608 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 335 | 4 | 2 | 2 | 3.7 | O=C(O)CCNC1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1 | 10.1021/jm100856p | ||
| CHEMBL1278114 | 18608 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 335 | 4 | 2 | 2 | 3.7 | O=C(O)CCNC1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1 | 10.1021/jm100856p | ||
| 17747460 | 61000 | 8 | None | - | 2 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL1767164 | 61000 | 8 | None | - | 2 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| 17747460 | 61000 | 8 | None | - | 2 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL1767164 | 61000 | 8 | None | - | 2 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmcl.2016.11.022 | ||
| 52937018 | 60971 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 355 | 6 | 0 | 4 | 3.6 | CN(C)CCCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767135 | 60971 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 355 | 6 | 0 | 4 | 3.6 | CN(C)CCCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 17747460 | 61000 | 8 | None | - | 2 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767164 | 61000 | 8 | None | - | 2 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 49836636 | 18490 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 375 | 2 | 1 | 3 | 4.5 | O=C(O)C1=CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277125 | 18490 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 375 | 2 | 1 | 3 | 4.5 | O=C(O)C1=CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836522 | 18607 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 376 | 2 | 2 | 3 | 3.0 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1 | 10.1021/jm100856p | ||
| CHEMBL1278113 | 18607 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 376 | 2 | 2 | 3 | 3.0 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1 | 10.1021/jm100856p | ||
| 11648990 | 95202 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 498 | 6 | 0 | 8 | 5.4 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL257946 | 95202 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 498 | 6 | 0 | 8 | 5.4 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 185 | 3943 | 54 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | 10.1021/jm100856p | ||
| 5311271 | 3943 | 54 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | 10.1021/jm100856p | ||
| CHEMBL74355 | 3943 | 54 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | 10.1021/jm100856p | ||
| DB16351 | 3943 | 54 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | 10.1021/jm100856p | ||
| 49836740 | 18517 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 425 | 2 | 1 | 4 | 4.9 | O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277401 | 18517 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 425 | 2 | 1 | 4 | 4.9 | O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)CC1 | 10.1021/jm100856p | ||
| 44454458 | 94682 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 618 | 6 | 0 | 8 | 7.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL255566 | 94682 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 618 | 6 | 0 | 8 | 7.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 44454382 | 95138 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 517 | 6 | 0 | 8 | 5.2 | Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccc(Cl)cn6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL257716 | 95138 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 517 | 6 | 0 | 8 | 5.2 | Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccc(Cl)cn6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 11642163 | 97056 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 522 | 6 | 0 | 9 | 5.3 | Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL270376 | 97056 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 522 | 6 | 0 | 9 | 5.3 | Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1 | 10.1016/j.bmcl.2007.12.042 | ||
| 11663526 | 97303 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 514 | 6 | 0 | 8 | 5.8 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL271632 | 97303 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 514 | 6 | 0 | 8 | 5.8 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 44454223 | 97525 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 542 | 6 | 0 | 8 | 4.7 | CC(=O)N1CCOc2cc3c(cc21)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL272702 | 97525 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 542 | 6 | 0 | 8 | 4.7 | CC(=O)N1CCOc2cc3c(cc21)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 11527195 | 97608 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 590 | 6 | 0 | 8 | 6.5 | Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL273165 | 97608 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 590 | 6 | 0 | 8 | 6.5 | Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 11721190 | 154735 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 578 | 7 | 0 | 10 | 5.8 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL402853 | 154735 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 578 | 7 | 0 | 10 | 5.8 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 134143913 | 149797 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 497 | 9 | 0 | 6 | 5.1 | N#Cc1ccc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2ncccc12 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3953018 | 149797 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 497 | 9 | 0 | 6 | 5.1 | N#Cc1ccc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2ncccc12 | 10.1016/j.bmcl.2016.11.022 | ||
| 57393573 | 69366 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 406 | 7 | 0 | 5 | 3.4 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935439 | 69366 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 406 | 7 | 0 | 5 | 3.4 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 49836525 | 18619 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1278202 | 18619 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 57780020 | 142918 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 600 | 15 | 1 | 6 | 6.6 | CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3898341 | 142918 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 600 | 15 | 1 | 6 | 6.6 | CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 57780017 | 147586 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 544 | 12 | 1 | 6 | 5.3 | O=C(O)CCc1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3935303 | 147586 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 544 | 12 | 1 | 6 | 5.3 | O=C(O)CCc1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| 49834051 | 15571 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 364 | 3 | 1 | 5 | 2.2 | O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222626 | 15571 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 364 | 3 | 1 | 5 | 2.2 | O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1 | 10.1016/j.bmcl.2010.07.029 | ||
| 24803639 | 61002 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 622 | 14 | 1 | 7 | 6.8 | O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767166 | 61002 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 622 | 14 | 1 | 7 | 6.8 | O=c1c2ccccc2c(Cc2ccc(O)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 24803483 | 61003 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 654 | 15 | 0 | 6 | 8.2 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767167 | 61003 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 654 | 15 | 0 | 6 | 8.2 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 49836738 | 18507 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 377 | 2 | 1 | 3 | 4.6 | O=C(O)[C@@H]1CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277311 | 18507 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 377 | 2 | 1 | 3 | 4.6 | O=C(O)[C@@H]1CCCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 11591601 | 154794 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 512 | 7 | 0 | 8 | 5.6 | CCc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL403181 | 154794 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 512 | 7 | 0 | 8 | 5.6 | CCc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 49833882 | 15584 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 392 | 3 | 1 | 5 | 3.0 | O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222692 | 15584 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 392 | 3 | 1 | 5 | 3.0 | O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| 49833886 | 15602 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 2.5 | COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222764 | 15602 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 2.5 | COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| 11657494 | 95065 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 644 | 7 | 0 | 8 | 7.2 | Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL257369 | 95065 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 644 | 7 | 0 | 8 | 7.2 | Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 11641641 | 97058 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 487 | 6 | 0 | 7 | 5.2 | Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL270387 | 97058 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 487 | 6 | 0 | 7 | 5.2 | Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1 | 10.1016/j.bmcl.2007.12.042 | ||
| 24749507 | 13894 | 4 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 421 | 7 | 0 | 4 | 3.4 | O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL1197067 | 13894 | 4 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 421 | 7 | 0 | 4 | 3.4 | O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL559206 | 13894 | 4 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 421 | 7 | 0 | 4 | 3.4 | O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| 57397055 | 69362 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 390 | 5 | 0 | 5 | 4.6 | Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935435 | 69362 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 390 | 5 | 0 | 5 | 4.6 | Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 49836294 | 18592 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 387 | 2 | 0 | 3 | 4.4 | COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1278020 | 18592 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 387 | 2 | 0 | 3 | 4.4 | COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836524 | 18618 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 361 | 2 | 1 | 2 | 4.0 | O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1278201 | 18618 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 361 | 2 | 1 | 2 | 4.0 | O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 134136763 | 142316 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 500 | 11 | 0 | 5 | 6.0 | c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3893197 | 142316 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 500 | 11 | 0 | 5 | 6.0 | c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 57780007 | 146458 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 572 | 13 | 1 | 6 | 5.8 | CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3926412 | 146458 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 572 | 13 | 1 | 6 | 5.8 | CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 24803797 | 60754 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 626 | 11 | 0 | 6 | 7.6 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| CHEMBL1765111 | 60754 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 626 | 11 | 0 | 6 | 7.6 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| 24803798 | 60996 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 640 | 12 | 0 | 6 | 7.9 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| CHEMBL1767160 | 60996 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 640 | 12 | 0 | 6 | 7.9 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| 49836737 | 18498 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 395 | 2 | 1 | 3 | 4.7 | O=C(O)C1(F)CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277217 | 18498 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 395 | 2 | 1 | 3 | 4.7 | O=C(O)C1(F)CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836189 | 18593 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1278021 | 18593 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 44454309 | 97190 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 514 | 6 | 1 | 8 | 4.3 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL271066 | 97190 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 514 | 6 | 1 | 8 | 4.3 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 11568714 | 94863 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 454 | 6 | 0 | 9 | 4.3 | Cc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL256471 | 94863 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 454 | 6 | 0 | 9 | 4.3 | Cc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 11606378 | 94871 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 548 | 7 | 0 | 8 | 6.2 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(C)(F)F)oc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL256488 | 94871 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 548 | 7 | 0 | 8 | 6.2 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(C)(F)F)oc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 11533473 | 97102 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 503 | 6 | 0 | 9 | 4.3 | Cc1cnc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL270602 | 97102 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 503 | 6 | 0 | 9 | 4.3 | Cc1cnc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1 | 10.1016/j.bmcl.2007.12.042 | ||
| 44454401 | 154601 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 554 | 6 | 0 | 8 | 6.7 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL402087 | 154601 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 554 | 6 | 0 | 8 | 6.7 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 11504077 | 168263 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 488 | 7 | 0 | 9 | 4.6 | Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(C)(F)F)nc4c3CC2)n1C | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL437792 | 168263 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 488 | 7 | 0 | 9 | 4.6 | Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(C)(F)F)nc4c3CC2)n1C | 10.1016/j.bmcl.2007.12.042 | ||
| 52937733 | 60986 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 393 | 6 | 0 | 6 | 3.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1OC | 10.1021/jm1013874 | ||
| CHEMBL1767150 | 60986 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 393 | 6 | 0 | 6 | 3.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1OC | 10.1021/jm1013874 | ||
| 57391843 | 69361 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 436 | 5 | 0 | 5 | 3.3 | O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCOCC1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935434 | 69361 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 436 | 5 | 0 | 5 | 3.3 | O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCOCC1 | 10.1016/j.bmcl.2011.10.115 | ||
| 24804150 | 80070 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 641 | 14 | 0 | 7 | 7.2 | O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| CHEMBL2146813 | 80070 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 641 | 14 | 0 | 7 | 7.2 | O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1016/j.bmc.2012.08.032 | ||
| 49836412 | 18537 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277584 | 18537 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836295 | 18579 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277935 | 18579 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 57780008 | 149194 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 472 | 9 | 0 | 5 | 5.2 | c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3947980 | 149194 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 472 | 9 | 0 | 5 | 5.2 | c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 49864886 | 15569 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 2.6 | CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222624 | 15569 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 2.6 | CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 24803799 | 60997 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 654 | 13 | 0 | 6 | 8.3 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCCc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| CHEMBL1767161 | 60997 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 654 | 13 | 0 | 6 | 8.3 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCCc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| 49836635 | 18480 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 359 | 2 | 1 | 2 | 4.0 | O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277035 | 18480 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 359 | 2 | 1 | 2 | 4.0 | O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836741 | 18526 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 425 | 2 | 1 | 4 | 4.8 | O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(F)ccc2Sc2ccccc23)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277491 | 18526 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 425 | 2 | 1 | 4 | 4.8 | O=C(O)C1CCN(C2CCC3(C2)C(=O)c2cc(F)ccc2Sc2ccccc23)CC1 | 10.1021/jm100856p | ||
| 49836842 | 18527 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 425 | 2 | 1 | 4 | 4.9 | O=C(O)[C@@H]1CCCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)C1 | 10.1021/jm100856p | ||
| CHEMBL1277492 | 18527 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 425 | 2 | 1 | 4 | 4.9 | O=C(O)[C@@H]1CCCN(C2CCC3(C2)C(=O)c2cc(Cl)ccc2Oc2ccccc23)C1 | 10.1021/jm100856p | ||
| 57780016 | 149764 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 542 | 11 | 1 | 6 | 5.3 | O=C(O)/C=C/c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3952802 | 149764 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 542 | 11 | 1 | 6 | 5.3 | O=C(O)/C=C/c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| 11585248 | 94870 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 604 | 8 | 0 | 8 | 6.8 | CCc1nc2cc3c(c(Br)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL256482 | 94870 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 604 | 8 | 0 | 8 | 6.8 | CCc1nc2cc3c(c(Br)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 11669953 | 95096 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 468 | 6 | 0 | 9 | 2.7 | Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)N(C)C(=O)CO4)n1C | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL257534 | 95096 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 468 | 6 | 0 | 9 | 2.7 | Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)N(C)C(=O)CO4)n1C | 10.1016/j.bmcl.2007.12.066 | ||
| 44454278 | 95097 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 454 | 6 | 1 | 9 | 2.7 | Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL257536 | 95097 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 454 | 6 | 1 | 9 | 2.7 | Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C | 10.1016/j.bmcl.2007.12.066 | ||
| 11621352 | 97184 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 602 | 7 | 0 | 8 | 6.7 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL271034 | 97184 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 602 | 7 | 0 | 8 | 6.7 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 11677768 | 155034 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 502 | 6 | 0 | 8 | 4.9 | Cc1ccc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL404404 | 155034 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 502 | 6 | 0 | 8 | 4.9 | Cc1ccc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1 | 10.1016/j.bmcl.2007.12.042 | ||
| 44454353 | 155880 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 483 | 6 | 0 | 8 | 4.6 | Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccccn6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL406678 | 155880 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 483 | 6 | 0 | 8 | 4.6 | Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccccn6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 15986135 | 12223 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 457 | 7 | 0 | 4 | 3.7 | O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL1185220 | 12223 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 457 | 7 | 0 | 4 | 3.7 | O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL398812 | 12223 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 457 | 7 | 0 | 4 | 3.7 | O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| 15986915 | 12665 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 455 | 7 | 0 | 4 | 4.1 | O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL1187963 | 12665 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 455 | 7 | 0 | 4 | 4.1 | O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL534512 | 12665 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 455 | 7 | 0 | 4 | 4.1 | O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| 24749508 | 12680 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 446 | 7 | 0 | 5 | 3.3 | N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1 | 10.1021/jm0708228 | ||
| CHEMBL1188060 | 12680 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 446 | 7 | 0 | 5 | 3.3 | N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1 | 10.1021/jm0708228 | ||
| CHEMBL534958 | 12680 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 446 | 7 | 0 | 5 | 3.3 | N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1 | 10.1021/jm0708228 | ||
| 15986914 | 12749 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 435 | 7 | 0 | 4 | 3.7 | Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1 | 10.1021/jm0708228 | ||
| CHEMBL1188657 | 12749 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 435 | 7 | 0 | 4 | 3.7 | Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1 | 10.1021/jm0708228 | ||
| CHEMBL536991 | 12749 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 435 | 7 | 0 | 4 | 3.7 | Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1 | 10.1021/jm0708228 | ||
| 15987452 | 91002 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 443 | 7 | 0 | 4 | 3.3 | O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL240352 | 91002 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 443 | 7 | 0 | 4 | 3.3 | O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| 1524 | 2150 | 89 | None | - | 10 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm300338m | ||
| 197 | 2150 | 89 | None | - | 10 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm300338m | ||
| 3822 | 2150 | 89 | None | - | 10 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm300338m | ||
| 88 | 2150 | 89 | None | - | 10 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm300338m | ||
| CHEMBL51 | 2150 | 89 | None | - | 10 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm300338m | ||
| DB12465 | 2150 | 89 | None | - | 10 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/jm300338m | ||
| 45358442 | 60994 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1 | 10.1021/jm1013874 | ||
| CHEMBL1767158 | 60994 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 381 | 3 | 0 | 4 | 4.3 | CN1CCCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1 | 10.1021/jm1013874 | ||
| 53359025 | 62024 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 339 | 5 | 1 | 3 | 2.5 | O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1 | 10.1016/j.bmcl.2011.04.098 | ||
| CHEMBL1779058 | 62024 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 339 | 5 | 1 | 3 | 2.5 | O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1 | 10.1016/j.bmcl.2011.04.098 | ||
| 57404031 | 69367 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 402 | 7 | 0 | 6 | 4.5 | c1ccc(OCCn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935440 | 69367 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 402 | 7 | 0 | 6 | 4.5 | c1ccc(OCCn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 49836411 | 18538 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 389 | 3 | 1 | 2 | 4.8 | O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277585 | 18538 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 389 | 3 | 1 | 2 | 4.8 | O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836295 | 18579 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277935 | 18579 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836187 | 18609 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 335 | 4 | 2 | 2 | 3.7 | O=C(O)CCNC1CC[C@@]2(Cc3ccccc3Cc3ccccc32)C1 | 10.1021/jm100856p | ||
| CHEMBL1278115 | 18609 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 335 | 4 | 2 | 2 | 3.7 | O=C(O)CCNC1CC[C@@]2(Cc3ccccc3Cc3ccccc32)C1 | 10.1021/jm100856p | ||
| 23582308 | 145331 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 634 | 14 | 1 | 6 | 6.9 | O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3917428 | 145331 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 634 | 14 | 1 | 6 | 6.9 | O=C(O)CCc1ccc2cc(Cc3ccccc3)cc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| 46933089 | 15557 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 2.5 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222554 | 15557 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 2.5 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 49834051 | 15571 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 364 | 3 | 1 | 5 | 2.2 | O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222626 | 15571 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 364 | 3 | 1 | 5 | 2.2 | O=C(O)C1CC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)C1 | 10.1016/j.bmcl.2010.07.029 | ||
| 24803482 | 61004 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767168 | 61004 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 11627879 | 94903 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 528 | 6 | 0 | 8 | 4.3 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(C)C(=O)CO6)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL256652 | 94903 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 528 | 6 | 0 | 8 | 4.3 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(C)C(=O)CO6)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 11577158 | 97358 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 514 | 6 | 0 | 8 | 5.8 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL271909 | 97358 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 514 | 6 | 0 | 8 | 5.8 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 134143679 | 145369 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 516 | 10 | 1 | 6 | 4.9 | O=C(O)c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3917794 | 145369 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 516 | 10 | 1 | 6 | 4.9 | O=C(O)c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 | 10.1016/j.bmcl.2016.11.022 | ||
| 44454120 | 94729 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 438 | 6 | 0 | 9 | 3.8 | Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL255827 | 94729 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 438 | 6 | 0 | 9 | 3.8 | Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 11548755 | 97206 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 580 | 7 | 0 | 8 | 6.8 | Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL271097 | 97206 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 580 | 7 | 0 | 8 | 6.8 | Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 44454443 | 97314 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 449 | 6 | 0 | 9 | 3.6 | Cc1cnc(-c2nnc(SCCCN3CCc4ccc5c(C)noc5c4CC3)n2C)cn1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL271702 | 97314 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 449 | 6 | 0 | 9 | 3.6 | Cc1cnc(-c2nnc(SCCCN3CCc4ccc5c(C)noc5c4CC3)n2C)cn1 | 10.1016/j.bmcl.2007.12.042 | ||
| 11641596 | 97349 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 484 | 6 | 0 | 8 | 5.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6ncoc6cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL271844 | 97349 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 484 | 6 | 0 | 8 | 5.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6ncoc6cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 15986645 | 12761 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 451 | 5 | 0 | 4 | 3.7 | O=C(c1ccc(F)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL1188742 | 12761 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 451 | 5 | 0 | 4 | 3.7 | O=C(c1ccc(F)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| CHEMBL537219 | 12761 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 451 | 5 | 0 | 4 | 3.7 | O=C(c1ccc(F)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1 | 10.1021/jm0708228 | ||
| 44250284 | 193552 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 436 | 6 | 0 | 5 | 4.6 | CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL550818 | 193552 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 436 | 6 | 0 | 5 | 4.6 | CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2011.10.115 | ||
| 52944115 | 18610 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 291 | 1 | 0 | 1 | 4.2 | CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1 | 10.1021/jm100856p | ||
| CHEMBL1278116 | 18610 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 291 | 1 | 0 | 1 | 4.2 | CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1 | 10.1021/jm100856p | ||
| 49836526 | 18461 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 375 | 3 | 1 | 2 | 4.4 | O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1276859 | 18461 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 375 | 3 | 1 | 2 | 4.4 | O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836528 | 18471 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.0 | O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2 | 10.1021/jm100856p | ||
| CHEMBL1276947 | 18471 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.0 | O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2 | 10.1021/jm100856p | ||
| 49834052 | 15570 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 350 | 4 | 1 | 5 | 2.0 | C=C(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222625 | 15570 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 350 | 4 | 1 | 5 | 2.0 | C=C(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 52937828 | 60988 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 347 | 5 | 0 | 4 | 3.3 | CN1CCC[C@@H]1Cn1nc(CCc2ccccc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767152 | 60988 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 347 | 5 | 0 | 4 | 3.3 | CN1CCC[C@@H]1Cn1nc(CCc2ccccc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 49836634 | 18479 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 361 | 3 | 1 | 2 | 4.0 | O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277034 | 18479 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 361 | 3 | 1 | 2 | 4.0 | O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 44454434 | 97458 | 0 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 512 | 6 | 0 | 7 | 4.5 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL272480 | 97458 | 0 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 512 | 6 | 0 | 7 | 4.5 | Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.066 | ||
| 57400502 | 69370 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 321 | 3 | 1 | 4 | 3.4 | Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935443 | 69370 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 321 | 3 | 1 | 4 | 3.4 | Cc1ccc(Cn2c(C3CNCCO3)nc3ccccc32)cc1C | 10.1016/j.bmcl.2011.10.115 | ||
| 49836527 | 18462 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 3.9 | O=C(O)[C@@H]1[C@H]2CN(C3CCC4(Cc5ccccc5Cc5ccccc54)C3)C[C@H]21 | 10.1021/jm100856p | ||
| CHEMBL1276860 | 18462 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 3.9 | O=C(O)[C@@H]1[C@H]2CN(C3CCC4(Cc5ccccc5Cc5ccccc54)C3)C[C@H]21 | 10.1021/jm100856p | ||
| 49836410 | 18548 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 393 | 2 | 1 | 2 | 4.5 | O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277678 | 18548 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 393 | 2 | 1 | 2 | 4.5 | O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836298 | 18566 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277854 | 18566 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836296 | 18567 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 391 | 2 | 1 | 2 | 4.5 | O=C(O)C1=CCCN(C2CCC3(Cc4cc(F)ccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277855 | 18567 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 391 | 2 | 1 | 2 | 4.5 | O=C(O)C1=CCCN(C2CCC3(Cc4cc(F)ccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 57780018 | 144020 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 544 | 12 | 1 | 6 | 5.3 | O=C(O)CCc1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3907368 | 144020 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 544 | 12 | 1 | 6 | 5.3 | O=C(O)CCc1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 49833883 | 15585 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 3.1 | Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222693 | 15585 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 3.1 | Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| 46933090 | 15600 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 3.1 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222762 | 15600 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 3.1 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 49834053 | 15601 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 384 | 4 | 1 | 5 | 2.6 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222763 | 15601 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 384 | 4 | 1 | 5 | 2.6 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 24803316 | 60998 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 600 | 15 | 1 | 6 | 6.9 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1CCNCCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767162 | 60998 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 600 | 15 | 1 | 6 | 6.9 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1CCNCCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm1013874 | ||
| 24803480 | 60999 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 614 | 15 | 0 | 6 | 7.2 | CN(CCCCc1ccc(OCCCN2CCCCCC2)cc1)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767163 | 60999 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 614 | 15 | 0 | 6 | 7.2 | CN(CCCCc1ccc(OCCCN2CCCCCC2)cc1)CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 11548239 | 94855 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 528 | 7 | 0 | 8 | 6.1 | CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL256442 | 94855 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 528 | 7 | 0 | 8 | 6.1 | CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.042 | ||
| 134150412 | 151570 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 516 | 10 | 1 | 6 | 4.9 | O=C(O)c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3967709 | 151570 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 516 | 10 | 1 | 6 | 4.9 | O=C(O)c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 52937632 | 60979 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 389 | 4 | 0 | 4 | 4.4 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(C(C)(C)C)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767142 | 60979 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 389 | 4 | 0 | 4 | 4.4 | CN1CCC[C@@H]1Cn1nc(Cc2ccc(C(C)(C)C)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 11497679 | 155024 | 0 | None | - | 0 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 552 | 6 | 0 | 8 | 6.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(F)(F)F)oc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL404363 | 155024 | 0 | None | - | 0 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 552 | 6 | 0 | 8 | 6.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(F)(F)F)oc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 57400504 | 69372 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 327 | 3 | 1 | 4 | 3.6 | Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935445 | 69372 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 327 | 3 | 1 | 4 | 3.6 | Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57402314 | 69360 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 434 | 5 | 0 | 4 | 4.4 | O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCCCC1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935433 | 69360 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 434 | 5 | 0 | 4 | 4.4 | O=C(CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1)N1CCCCC1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57393573 | 69366 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 406 | 7 | 0 | 5 | 3.4 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935439 | 69366 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 406 | 7 | 0 | 5 | 3.4 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 16681693 | 82160 | 1 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 487 | 5 | 1 | 5 | 3.6 | Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 | 10.1021/jm300682j | ||
| CHEMBL2178580 | 82160 | 1 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 487 | 5 | 1 | 5 | 3.6 | Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 | 10.1021/jm300682j | ||
| 52937629 | 60975 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 377 | 6 | 0 | 5 | 3.5 | CCOc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767139 | 60975 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 377 | 6 | 0 | 5 | 3.5 | CCOc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| 57395286 | 69358 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 394 | 5 | 0 | 4 | 3.5 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935431 | 69358 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 394 | 5 | 0 | 4 | 3.5 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 49836637 | 18491 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 375 | 2 | 1 | 3 | 4.5 | O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277126 | 18491 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 375 | 2 | 1 | 3 | 4.5 | O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 25184832 | 18508 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 349 | 2 | 1 | 3 | 3.8 | O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277312 | 18508 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 349 | 2 | 1 | 3 | 3.8 | O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 49836409 | 18549 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 391 | 2 | 2 | 3 | 3.5 | O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277679 | 18549 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 391 | 2 | 2 | 3 | 3.5 | O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836300 | 18556 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 389 | 2 | 1 | 2 | 4.8 | CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277769 | 18556 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 389 | 2 | 1 | 2 | 4.8 | CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836299 | 18557 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277770 | 18557 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49834050 | 15556 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 338 | 4 | 1 | 5 | 1.8 | O=C(O)CCN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222553 | 15556 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 338 | 4 | 1 | 5 | 1.8 | O=C(O)CCN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| 49864885 | 15568 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 380 | 4 | 1 | 5 | 2.9 | CC(C)(CN1CCCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222623 | 15568 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 380 | 4 | 1 | 5 | 2.9 | CC(C)(CN1CCCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 49833884 | 15586 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 380 | 4 | 1 | 5 | 2.8 | Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222694 | 15586 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 380 | 4 | 1 | 5 | 2.8 | Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2 | 10.1016/j.bmcl.2010.07.029 | ||
| 24803641 | 60995 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 612 | 10 | 0 | 6 | 7.5 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(Cc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| CHEMBL1767159 | 60995 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 612 | 10 | 0 | 6 | 7.5 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(Cc2ccc(OCCCN3CCCCCC3)cc2)CC1 | 10.1021/jm1013874 | ||
| 11497680 | 97403 | 6 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 552 | 6 | 0 | 8 | 6.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL272150 | 97403 | 6 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 552 | 6 | 0 | 8 | 6.1 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 11519133 | 168856 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 512 | 7 | 0 | 8 | 5.6 | CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL442456 | 168856 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 512 | 7 | 0 | 8 | 5.6 | CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.042 | ||
| 57398829 | 69359 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 422 | 7 | 0 | 4 | 4.3 | CCN(CC)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935432 | 69359 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 422 | 7 | 0 | 4 | 4.3 | CCN(CC)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 49836633 | 18472 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 347 | 2 | 1 | 2 | 3.6 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1276948 | 18472 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 347 | 2 | 1 | 2 | 3.6 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 52937119 | 60991 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.6 | CN1CCC(Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1 | 10.1021/jm1013874 | ||
| CHEMBL1767155 | 60991 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 367 | 4 | 0 | 4 | 3.6 | CN1CCC(Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1 | 10.1021/jm1013874 | ||
| 45272895 | 193984 | 9 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 389 | 4 | 0 | 5 | 4.6 | Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL556450 | 193984 | 9 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 389 | 4 | 0 | 5 | 4.6 | Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57400503 | 69371 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 323 | 3 | 1 | 4 | 3.8 | Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935444 | 69371 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 323 | 3 | 1 | 4 | 3.8 | Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 49836414 | 18606 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 377 | 2 | 1 | 3 | 3.4 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCO1 | 10.1021/jm100856p | ||
| CHEMBL1278112 | 18606 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 377 | 2 | 1 | 3 | 3.4 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCO1 | 10.1021/jm100856p | ||
| 49833882 | 15584 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 392 | 3 | 1 | 5 | 3.0 | O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222692 | 15584 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 392 | 3 | 1 | 5 | 3.0 | O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1 | 10.1016/j.bmcl.2010.07.029 | ||
| 52937223 | 60993 | 19 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 381 | 5 | 0 | 4 | 4.1 | CN1CCCC1CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767157 | 60993 | 19 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 381 | 5 | 0 | 4 | 4.1 | CN1CCCC1CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 143 | 3459 | 45 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 438 | 5 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2 | 10.1016/j.bmcl.2007.12.042 | ||
| 143 | 3459 | 45 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 438 | 5 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2 | 10.1016/j.bmcl.2007.12.066 | ||
| 5311096 | 3459 | 45 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 438 | 5 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2 | 10.1016/j.bmcl.2007.12.042 | ||
| 5311096 | 3459 | 45 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 438 | 5 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL85606 | 3459 | 45 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 438 | 5 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL85606 | 3459 | 45 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 438 | 5 | 1 | 4 | 4.8 | N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2 | 10.1016/j.bmcl.2007.12.066 | ||
| 11569996 | 94868 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 525 | 7 | 0 | 8 | 5.4 | CCc1nn(C)c2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL256477 | 94868 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 525 | 7 | 0 | 8 | 5.4 | CCc1nn(C)c2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 11518972 | 154493 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 501 | 6 | 0 | 7 | 5.5 | Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL401576 | 154493 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 501 | 6 | 0 | 7 | 5.5 | Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3 | 10.1016/j.bmcl.2007.12.066 | ||
| 52937633 | 60980 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 391 | 5 | 0 | 6 | 2.9 | COC(=O)c1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767143 | 60980 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 391 | 5 | 0 | 6 | 2.9 | COC(=O)c1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| 24803638 | 61001 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 636 | 15 | 0 | 7 | 7.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| CHEMBL1767165 | 61001 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 636 | 15 | 0 | 7 | 7.1 | COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1 | 10.1021/jm1013874 | ||
| 49836639 | 18497 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 377 | 2 | 1 | 3 | 4.6 | O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277216 | 18497 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 377 | 2 | 1 | 3 | 4.6 | O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 49836739 | 18516 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 387 | 2 | 1 | 3 | 4.0 | O=C(O)C1=CCCN(C2CCC3(C2)C(=O)c2ccccc2Cc2ccccc23)C1 | 10.1021/jm100856p | ||
| CHEMBL1277400 | 18516 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 387 | 2 | 1 | 3 | 4.0 | O=C(O)C1=CCCN(C2CCC3(C2)C(=O)c2ccccc2Cc2ccccc23)C1 | 10.1021/jm100856p | ||
| 134139893 | 145880 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 486 | 10 | 0 | 5 | 5.6 | c1cnc2c(N3CCN(CCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| CHEMBL3921827 | 145880 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 486 | 10 | 0 | 5 | 5.6 | c1cnc2c(N3CCN(CCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 | 10.1016/j.bmcl.2016.11.022 | ||
| 46933091 | 15587 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 3.1 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| CHEMBL1222695 | 15587 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 3.1 | CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O | 10.1016/j.bmcl.2010.07.029 | ||
| 52937734 | 60987 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 339 | 4 | 0 | 4 | 3.6 | CN1CCC[C@@H]1Cn1nc(CC2CCCCC2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| CHEMBL1767151 | 60987 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 339 | 4 | 0 | 4 | 3.6 | CN1CCC[C@@H]1Cn1nc(CC2CCCCC2)c2ccccc2c1=O | 10.1021/jm1013874 | ||
| 49836413 | 18590 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 393 | 2 | 1 | 2 | 4.5 | O=C(O)C1(F)CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1278019 | 18590 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 393 | 2 | 1 | 2 | 4.5 | O=C(O)C1(F)CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 11584660 | 92836 | 7 | None | - | 5 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 537 | 7 | 0 | 8 | 5.6 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL244946 | 92836 | 7 | None | - | 5 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 537 | 7 | 0 | 8 | 5.6 | Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 44454190 | 97615 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 537 | 7 | 0 | 8 | 5.6 | Cc1cc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2cn1 | 10.1016/j.bmcl.2007.12.066 | ||
| CHEMBL273199 | 97615 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 537 | 7 | 0 | 8 | 5.6 | Cc1cc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2cn1 | 10.1016/j.bmcl.2007.12.066 | ||
| 44454351 | 160060 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 551 | 6 | 0 | 8 | 5.6 | Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| CHEMBL411293 | 160060 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 551 | 6 | 0 | 8 | 5.6 | Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1 | 10.1016/j.bmcl.2007.12.042 | ||
| 57397055 | 69362 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 390 | 5 | 0 | 5 | 4.6 | Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935435 | 69362 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 390 | 5 | 0 | 5 | 4.6 | Fc1ccc(Cn2c(C3CCCN(Cc4ncco4)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57395286 | 69358 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 394 | 5 | 0 | 4 | 3.5 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935431 | 69358 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 394 | 5 | 0 | 4 | 3.5 | CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57402230 | 69375 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 339 | 4 | 1 | 5 | 3.5 | COc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935448 | 69375 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 339 | 4 | 1 | 5 | 3.5 | COc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 57400504 | 69372 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 327 | 3 | 1 | 4 | 3.6 | Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| CHEMBL1935445 | 69372 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 327 | 3 | 1 | 4 | 3.6 | Fc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.10.115 | ||
| 2247 | 502 | 77 | None | 1 | 34 | Human | 8.1 | pA2 | = | 8.1 | Functional | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 249 | 502 | 77 | None | 1 | 34 | Human | 8.1 | pA2 | = | 8.1 | Functional | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 2603 | 502 | 77 | None | 1 | 34 | Human | 8.1 | pA2 | = | 8.1 | Functional | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| CHEMBL296419 | 502 | 77 | None | 1 | 34 | Human | 8.1 | pA2 | = | 8.1 | Functional | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| DB00637 | 502 | 77 | None | 1 | 34 | Human | 8.1 | pA2 | = | 8.1 | Functional | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 1204 | 1901 | 114 | None | -8 | 10 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | None | -8 | 10 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | None | -8 | 10 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | None | -8 | 10 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | None | -8 | 10 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | None | -8 | 10 | Rat | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | None | -3 | 10 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1427 | 1982 | 50 | None | 5 | 10 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | None | 5 | 10 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | None | 5 | 10 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | None | 5 | 10 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | None | 5 | 10 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 4543 | 169982 | 36 | None | 6 | 25 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | None | 6 | 25 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | None | 6 | 25 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 180 | 397 | 50 | None | 3 | 26 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | None | 3 | 26 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | None | 3 | 26 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | None | 3 | 26 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | None | 3 | 26 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 40466858 | 15979 | 62 | None | -25 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | None | ||
| 5284514 | 15979 | 62 | None | -25 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | None | ||
| CHEMBL1224 | 15979 | 62 | None | -25 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | None | ||
| 1599 | 2309 | 47 | None | -3 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| 3955 | 2309 | 47 | None | -3 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| 7215 | 2309 | 47 | None | -3 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL841 | 2309 | 47 | None | -3 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| DB00836 | 2309 | 47 | None | -3 | 13 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| 4223 | 3929 | 88 | None | -199 | 15 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 6918314 | 3929 | 88 | None | -199 | 15 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 7427 | 3929 | 88 | None | -199 | 15 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| CHEMBL439849 | 3929 | 88 | None | -199 | 15 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| DB06684 | 3929 | 88 | None | -199 | 15 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 40466858 | 15979 | 62 | None | 25 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | None | ||
| 5284514 | 15979 | 62 | None | 25 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | None | ||
| CHEMBL1224 | 15979 | 62 | None | 25 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | None | ||
| 2762 | 3802 | 28 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 5587 | 3802 | 28 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 7318 | 3802 | 28 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| CHEMBL1241 | 3802 | 28 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| DB00792 | 3802 | 28 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 1427 | 1982 | 50 | None | -18 | 10 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | None | -18 | 10 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | None | -18 | 10 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | None | -18 | 10 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | None | -18 | 10 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 2337 | 3205 | 72 | None | -2 | 22 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | None | -2 | 22 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | None | -2 | 22 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | None | -2 | 22 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | None | -2 | 22 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 10103 | 3363 | 66 | None | 28 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 133017 | 3363 | 66 | None | 28 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 2413 | 3363 | 66 | None | 28 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| CHEMBL91397 | 3363 | 66 | None | 28 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| DB11614 | 3363 | 66 | None | 28 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 1027 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| 3241 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| 7176 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL1106 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| DB00751 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| 1224 | 1404 | 79 | None | 54 | 13 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | None | 54 | 13 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | None | 54 | 13 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | None | 54 | 13 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | None | 54 | 13 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | None | 54 | 13 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 2995 | 202700 | 49 | None | 2 | 6 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | None | 2 | 6 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | None | 2 | 6 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 2801 | 161325 | 56 | None | 2 | 24 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | None | ||
| CHEMBL1200710 | 161325 | 56 | None | 2 | 24 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | None | ||
| CHEMBL415 | 161325 | 56 | None | 2 | 24 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | None | ||
| 4223 | 3929 | 88 | None | -199 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 6918314 | 3929 | 88 | None | -199 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 7427 | 3929 | 88 | None | -199 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| CHEMBL439849 | 3929 | 88 | None | -199 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| DB06684 | 3929 | 88 | None | -199 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 2762 | 3802 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| 5587 | 3802 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| 7318 | 3802 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| CHEMBL1241 | 3802 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| DB00792 | 3802 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| 10103 | 3363 | 66 | None | 28 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 16220969 | ||
| 133017 | 3363 | 66 | None | 28 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 16220969 | ||
| 2413 | 3363 | 66 | None | 28 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 16220969 | ||
| CHEMBL91397 | 3363 | 66 | None | 28 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 16220969 | ||
| DB11614 | 3363 | 66 | None | 28 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 16220969 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 11327353 | 165069 | 0 | None | - | 0 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL424336 | 165069 | 0 | None | - | 0 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11201079 | 45957 | 0 | None | - | 0 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 424 | 12 | 2 | 3 | 5.3 | c1ccc(C(CCc2nc(CCNCCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153474 | 45957 | 0 | None | - | 0 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 424 | 12 | 2 | 3 | 5.3 | c1ccc(C(CCc2nc(CCNCCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11235688 | 119347 | 0 | None | - | 1 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 427 | 13 | 3 | 3 | 5.1 | c1ccc(C(CCc2nc(CCNCCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL348656 | 119347 | 0 | None | - | 1 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 427 | 13 | 3 | 3 | 5.1 | c1ccc(C(CCc2nc(CCNCCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 42625384 | 169206 | 0 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 209 | 4 | 3 | 2 | -0.2 | CC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL443896 | 169206 | 0 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 209 | 4 | 3 | 2 | -0.2 | CC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm020415q | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm020415q | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm020415q | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm020415q | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm020415q | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm020415q | ||
| 11407994 | 46215 | 0 | None | - | 0 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153736 | 46215 | 0 | None | - | 0 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11269940 | 46268 | 0 | None | - | 1 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 413 | 12 | 3 | 3 | 4.7 | c1ccc(C(CCc2nc(CCNCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153776 | 46268 | 0 | None | - | 1 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 413 | 12 | 3 | 3 | 4.7 | c1ccc(C(CCc2nc(CCNCCCc3c[nH]cn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10410901 | 119242 | 0 | None | 3 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL347796 | 119242 | 0 | None | 3 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11166893 | 45953 | 0 | None | - | 0 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 452 | 14 | 2 | 3 | 6.1 | c1ccc(C(CCc2nc(CCNCCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153468 | 45953 | 0 | None | - | 0 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 452 | 14 | 2 | 3 | 6.1 | c1ccc(C(CCc2nc(CCNCCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10447834 | 1902 | 4 | None | 8 | 6 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 4026 | 1902 | 4 | None | 8 | 6 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275507 | 1902 | 4 | None | 8 | 6 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 10403687 | 2475 | 2 | None | -7 | 6 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1205 | 2475 | 2 | None | -7 | 6 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275035 | 2475 | 2 | None | -7 | 6 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1204 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1247 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1375 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 774 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| CHEMBL90 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| DB05381 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 42626110 | 179189 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 310 | 5 | 4 | 2 | 1.6 | N/C(=N\C(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL474448 | 179189 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 310 | 5 | 4 | 2 | 1.6 | N/C(=N\C(=O)c1cc2ccccc2[nH]1)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 10447834 | 1902 | 4 | None | 8 | 6 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 4026 | 1902 | 4 | None | 8 | 6 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275507 | 1902 | 4 | None | 8 | 6 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm800841w | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm800841w | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm800841w | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm800841w | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm800841w | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm800841w | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.6b00120 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.6b00120 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.6b00120 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.6b00120 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.6b00120 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.03.082 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.03.082 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.03.082 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.03.082 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.03.082 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.bmcl.2010.03.082 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm9000693 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm9000693 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm9000693 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm9000693 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm9000693 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm9000693 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1039/C3MD00245D | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1039/C3MD00245D | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1039/C3MD00245D | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1039/C3MD00245D | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1039/C3MD00245D | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1039/C3MD00245D | ||
| 1204 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1247 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1375 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 774 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| CHEMBL90 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| DB05381 | 1901 | 114 | None | -46 | 23 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/np058114h | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/np058114h | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/np058114h | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/np058114h | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/np058114h | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/np058114h | ||
| 10364258 | 45512 | 0 | None | 2 | 2 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153067 | 45512 | 0 | None | 2 | 2 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11475781 | 45797 | 0 | None | - | 0 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 424 | 12 | 2 | 3 | 5.3 | c1ccc(C(CCc2nc(CCNCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153321 | 45797 | 0 | None | - | 0 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 424 | 12 | 2 | 3 | 5.3 | c1ccc(C(CCc2nc(CCNCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 42625386 | 177778 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 237 | 6 | 3 | 2 | 0.6 | CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL465170 | 177778 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 237 | 6 | 3 | 2 | 0.6 | CCCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 11453438 | 45445 | 0 | None | - | 0 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153010 | 45445 | 0 | None | - | 0 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10410901 | 119242 | 0 | None | -3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL347796 | 119242 | 0 | None | -3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 42625304 | 178522 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 237 | 5 | 3 | 2 | 0.4 | CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL471724 | 178522 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 237 | 5 | 3 | 2 | 0.4 | CC(C)C(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 11775345 | 41931 | 0 | None | - | 0 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 452 | 14 | 2 | 3 | 6.1 | c1ccc(C(CCc2nc(CCNCCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL149684 | 41931 | 0 | None | - | 0 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 452 | 14 | 2 | 3 | 6.1 | c1ccc(C(CCc2nc(CCNCCCCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11339274 | 119119 | 0 | None | - | 0 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 424 | 12 | 2 | 3 | 5.3 | c1ccc(C(CCc2nc(CCNCCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL346620 | 119119 | 0 | None | - | 0 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 424 | 12 | 2 | 3 | 5.3 | c1ccc(C(CCc2nc(CCNCCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11741669 | 96305 | 0 | None | -2 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL264491 | 96305 | 0 | None | -2 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 42625303 | 180184 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 223 | 5 | 3 | 2 | 0.2 | CCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| CHEMBL475621 | 180184 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 223 | 5 | 3 | 2 | 0.2 | CCC(=O)/N=C(\N)NCCCc1c[nH]cn1 | 10.1021/jm9000693 | ||
| 10403687 | 2475 | 2 | None | 7 | 6 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1205 | 2475 | 2 | None | 7 | 6 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275035 | 2475 | 2 | None | 7 | 6 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1204 | 1901 | 114 | None | -309 | 23 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1247 | 1901 | 114 | None | -309 | 23 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 1375 | 1901 | 114 | None | -309 | 23 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 774 | 1901 | 114 | None | -309 | 23 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| CHEMBL90 | 1901 | 114 | None | -309 | 23 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| DB05381 | 1901 | 114 | None | -309 | 23 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm0309147 | ||
| 11741669 | 96305 | 0 | None | 2 | 2 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL264491 | 96305 | 0 | None | 2 | 2 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10364258 | 45512 | 0 | None | -2 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153067 | 45512 | 0 | None | -2 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10403687 | 2475 | 2 | None | 7 | 6 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 1205 | 2475 | 2 | None | 7 | 6 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275035 | 2475 | 2 | None | 7 | 6 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 10410901 | 119242 | 0 | None | 3 | 2 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL347796 | 119242 | 0 | None | 3 | 2 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 438 | 13 | 2 | 3 | 5.7 | c1ccc(C(CCc2nc(CCNCCCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 46887041 | 8672 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 313 | 7 | 4 | 3 | 2.2 | C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1016/j.bmcl.2010.03.082 | ||
| CHEMBL1096428 | 8672 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 313 | 7 | 4 | 3 | 2.2 | C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1016/j.bmcl.2010.03.082 | ||
| 46887043 | 8675 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 319 | 7 | 4 | 3 | 2.6 | C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1016/j.bmcl.2010.03.082 | ||
| CHEMBL1096431 | 8675 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 319 | 7 | 4 | 3 | 2.6 | C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1016/j.bmcl.2010.03.082 | ||
| 11269875 | 120491 | 0 | None | - | 1 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL356449 | 120491 | 0 | None | - | 1 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 10364258 | 45512 | 0 | None | 2 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL153067 | 45512 | 0 | None | 2 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3ccccn3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11269875 | 120491 | 0 | None | - | 1 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL356449 | 120491 | 0 | None | - | 1 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 410 | 11 | 2 | 3 | 4.9 | c1ccc(C(CCc2nc(CCNCCc3cccnc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 46830167 | 8673 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 313 | 7 | 4 | 3 | 2.2 | C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1016/j.bmcl.2010.03.082 | ||
| CHEMBL1096429 | 8673 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 313 | 7 | 4 | 3 | 2.2 | C[C@@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1016/j.bmcl.2010.03.082 | ||
| 10447834 | 1902 | 4 | None | -8 | 6 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 4026 | 1902 | 4 | None | -8 | 6 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| CHEMBL275507 | 1902 | 4 | None | -8 | 6 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm0309147 | ||
| 10374457 | 28682 | 2 | None | - | 2 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 123 | 1 | 2 | 2 | 0.2 | N[C@H]1C[C@@H]1c1c[nH]cn1 | 10.1021/jm020415q | ||
| CHEMBL13795 | 28682 | 2 | None | - | 2 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 123 | 1 | 2 | 2 | 0.2 | N[C@H]1C[C@@H]1c1c[nH]cn1 | 10.1021/jm020415q | ||
| 46887042 | 8674 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 319 | 7 | 4 | 3 | 2.6 | C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1016/j.bmcl.2010.03.082 | ||
| CHEMBL1096430 | 8674 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 319 | 7 | 4 | 3 | 2.6 | C[C@H](CC(=O)NC(=N)NCCCc1c[nH]cn1)C1CCCCC1 | 10.1016/j.bmcl.2010.03.082 | ||
| 11741669 | 96305 | 0 | None | 2 | 2 | Guinea pig | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL264491 | 96305 | 0 | None | 2 | 2 | Guinea pig | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 399 | 11 | 3 | 3 | 4.3 | c1ccc(C(CCc2nc(CCNCCc3cnc[nH]3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 11178495 | 168103 | 0 | None | - | 0 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 452 | 14 | 2 | 3 | 6.1 | c1ccc(C(CCc2nc(CCNCCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| CHEMBL436415 | 168103 | 0 | None | - | 0 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 452 | 14 | 2 | 3 | 6.1 | c1ccc(C(CCc2nc(CCNCCCCCc3ccncc3)c[nH]2)c2ccccc2)cc1 | 10.1021/jm0309147 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.03.006 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.03.006 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.03.006 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.03.006 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.03.006 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.03.006 | ||
| 180 | 397 | 50 | None | -11 | 38 | Rat | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| 200 | 397 | 50 | None | -11 | 38 | Rat | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| 2160 | 397 | 50 | None | -11 | 38 | Rat | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| CHEMBL629 | 397 | 50 | None | -11 | 38 | Rat | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| DB00321 | 397 | 50 | None | -11 | 38 | Rat | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| 4543 | 169982 | 36 | None | -6 | 29 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | 10.1021/jm9910369 | ||
| CHEMBL1201156 | 169982 | 36 | None | -6 | 29 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | 10.1021/jm9910369 | ||
| CHEMBL445 | 169982 | 36 | None | -6 | 29 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | 10.1021/jm9910369 | ||
| 1427 | 1982 | 50 | None | -1 | 26 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| 357 | 1982 | 50 | None | -1 | 26 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| 3696 | 1982 | 50 | None | -1 | 26 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| CHEMBL11 | 1982 | 50 | None | -1 | 26 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| DB00458 | 1982 | 50 | None | -1 | 26 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm9910369 | ||
| 76316323 | 85202 | 0 | None | - | 0 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 314 | 2 | 1 | 6 | 1.6 | NC(=O)c1c(N2CCCC2)nc2sc3ccccc3n2c1=O | 10.1007/s00044-012-0100-4 | ||
| CHEMBL2283398 | 85202 | 0 | None | - | 0 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 314 | 2 | 1 | 6 | 1.6 | NC(=O)c1c(N2CCCC2)nc2sc3ccccc3n2c1=O | 10.1007/s00044-012-0100-4 | ||
| 2801 | 161325 | 56 | None | - | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | 10.1021/jm9910369 | ||
| CHEMBL1200710 | 161325 | 56 | None | - | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | 10.1021/jm9910369 | ||
| CHEMBL415 | 161325 | 56 | None | - | 28 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | 10.1021/jm9910369 | ||
| 13726621 | 94821 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 311 | 3 | 0 | 4 | 2.2 | CN1C[C@@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S | 10.1021/jm00108a012 | ||
| CHEMBL25626 | 94821 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 311 | 3 | 0 | 4 | 2.2 | CN1C[C@@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S | 10.1021/jm00108a012 | ||
| 26987 | 936 | 29 | None | 16 | 21 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| 6063 | 936 | 29 | None | 16 | 21 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| 671 | 936 | 29 | None | 16 | 21 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| CHEMBL1626 | 936 | 29 | None | 16 | 21 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| DB00283 | 936 | 29 | None | 16 | 21 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| 3158 | 55974 | 21 | None | 40 | 20 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | nan | ||
| CHEMBL1628227 | 55974 | 21 | None | 40 | 20 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | nan | ||
| 2995 | 202700 | 49 | None | -42 | 22 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | 10.1021/jm9910369 | ||
| CHEMBL1696 | 202700 | 49 | None | -42 | 22 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | 10.1021/jm9910369 | ||
| CHEMBL72 | 202700 | 49 | None | -42 | 22 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | 10.1021/jm9910369 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2013.03.016 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2013.03.016 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2013.03.016 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2013.03.016 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2013.03.016 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2013.03.016 | ||
| 1224 | 1404 | 79 | None | 1 | 13 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1021/jm00173a011 | ||
| 3100 | 1404 | 79 | None | 1 | 13 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1021/jm00173a011 | ||
| 8980 | 1404 | 79 | None | 1 | 13 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1021/jm00173a011 | ||
| 916 | 1404 | 79 | None | 1 | 13 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1021/jm00173a011 | ||
| CHEMBL657 | 1404 | 79 | None | 1 | 13 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1021/jm00173a011 | ||
| DB01075 | 1404 | 79 | None | 1 | 13 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1021/jm00173a011 | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmc.2011.03.003 | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmc.2011.03.003 | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmc.2011.03.003 | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmc.2011.03.003 | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmcl.2009.03.124 | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmcl.2009.03.124 | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmcl.2009.03.124 | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1016/j.bmcl.2009.03.124 | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm501535r | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm501535r | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm501535r | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm501535r | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm501535r | ||
| 137125256 | 122535 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 328 | 0 | 1 | 4 | 3.3 | CN1CCN(C2=Nc3cc(F)ccc3Nc3ccc(F)cc32)CC1 | 10.1021/acsmedchemlett.5b00102 | ||
| CHEMBL3609328 | 122535 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 328 | 0 | 1 | 4 | 3.3 | CN1CCN(C2=Nc3cc(F)ccc3Nc3ccc(F)cc32)CC1 | 10.1021/acsmedchemlett.5b00102 | ||
| 11976 | 907 | 54 | None | - | 23 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| 667467 | 907 | 54 | None | - | 23 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| CHEMBL908 | 907 | 54 | None | - | 23 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| DB01239 | 907 | 54 | None | - | 23 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1021/jm300671m | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 44318581 | 204200 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3cc(F)ccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL84081 | 204200 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3cc(F)ccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm058018d | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm058018d | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm058018d | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm058018d | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm058018d | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm058018d | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.11.014 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.11.014 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.11.014 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.11.014 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.11.014 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2016.11.014 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 1227 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2010.07.034 | ||
| 2331 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2010.07.034 | ||
| 3957 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2010.07.034 | ||
| 4992 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2010.07.034 | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2010.07.034 | ||
| DB06691 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmc.2010.07.034 | ||
| 135 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| 1027 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 3241 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 7176 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| CHEMBL1106 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| DB00751 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 44461456 | 204035 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.8 | CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL82714 | 204035 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.8 | CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 72548703 | 161019 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | ||
| CHEMBL4128926 | 161019 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | ||
| 44318554 | 106596 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3c(F)cccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL315834 | 106596 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3c(F)cccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm701575k | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm701575k | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm701575k | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm701575k | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm701575k | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm701575k | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2019.126712 | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2019.126712 | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2019.126712 | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2019.126712 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 13726596 | 93514 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 299 | 3 | 0 | 4 | 2.1 | CN(C)CC[C@@H]1CN(C)C(=S)c2cc(Cl)cnc2O1 | 10.1021/jm00108a012 | ||
| CHEMBL24835 | 93514 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 299 | 3 | 0 | 4 | 2.1 | CN(C)CC[C@@H]1CN(C)C(=S)c2cc(Cl)cnc2O1 | 10.1021/jm00108a012 | ||
| 19426635 | 203881 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 280 | 2 | 1 | 3 | 3.1 | CNCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL81485 | 203881 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 280 | 2 | 1 | 3 | 3.1 | CNCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 9869791 | 63595 | 12 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 0.9 | CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180632 | 63595 | 12 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 0.9 | CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 11453538 | 84320 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 442 | 10 | 1 | 6 | 4.7 | CCOCCn1cc(C2CCN(CCOc3ccsc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL222927 | 84320 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 442 | 10 | 1 | 6 | 4.7 | CCOCCn1cc(C2CCN(CCOc3ccsc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 11396873 | 136461 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 10 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(F)ccc21 | 10.1021/jm0498203 | ||
| CHEMBL374585 | 136461 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 10 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(F)ccc21 | 10.1021/jm0498203 | ||
| 1853 | 3495 | 27 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1021/jm058225d | ||
| 60680 | 3495 | 27 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1021/jm058225d | ||
| CHEMBL10971 | 3495 | 27 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1021/jm058225d | ||
| 1613 | 2316 | 44 | None | - | 44 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
| 205 | 2316 | 44 | None | - | 44 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
| 3964 | 2316 | 44 | None | - | 44 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
| CHEMBL831 | 2316 | 44 | None | - | 44 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
| DB00408 | 2316 | 44 | None | - | 44 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1021/jm991005d | ||
| 3689 | 102298 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 325 | 5 | 2 | 3 | 3.8 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | 10.1021/jm00114a018 | ||
| CHEMBL1372983 | 102298 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 325 | 5 | 2 | 3 | 3.8 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | 10.1021/jm00114a018 | ||
| CHEMBL305187 | 102298 | 47 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 325 | 5 | 2 | 3 | 3.8 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | 10.1021/jm00114a018 | ||
| 11430418 | 18599 | 11 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 2.5 | Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 | 10.1021/jm1002292 | ||
| CHEMBL1278088 | 18599 | 11 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 2.5 | Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2 | 10.1021/jm1002292 | ||
| 11459394 | 47902 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 251 | 12 | 2 | 2 | 3.8 | NCCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL155188 | 47902 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 251 | 12 | 2 | 2 | 3.8 | NCCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 5310982 | 93179 | 4 | None | - | 3 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1021/jm030936t | ||
| CHEMBL24665 | 93179 | 4 | None | - | 3 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 255 | 3 | 2 | 2 | 2.6 | NCCc1c[nH]c(-c2cccc(C(F)(F)F)c2)n1 | 10.1021/jm030936t | ||
| 107782 | 14330 | 16 | None | 1 | 5 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | nan | ||
| 67151996 | 14330 | 16 | None | 1 | 5 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | nan | ||
| CHEMBL1201207 | 14330 | 16 | None | 1 | 5 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | nan | ||
| 44461357 | 103895 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 330 | 2 | 0 | 4 | 4.3 | CN(C)CC1CC2c3ccccc3Oc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL310183 | 103895 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 330 | 2 | 0 | 4 | 4.3 | CN(C)CC1CC2c3ccccc3Oc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 10205121 | 66359 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 464 | 6 | 1 | 4 | 6.5 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1 | 10.1021/jm0498203 | ||
| CHEMBL185489 | 66359 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 464 | 6 | 1 | 4 | 6.5 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1 | 10.1021/jm0498203 | ||
| 45268185 | 194433 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 535 | 8 | 1 | 9 | 2.9 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL560917 | 194433 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 535 | 8 | 1 | 9 | 2.9 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 14762577 | 4402 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 336 | 6 | 1 | 2 | 3.7 | Cc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| CHEMBL101790 | 4402 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 336 | 6 | 1 | 2 | 3.7 | Cc1ccccc1C(=O)NCCN1CCC(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| 44318841 | 106444 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1cccc2c1C1CC(CN(C)C)ON1c1ccccc1C2 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL314795 | 106444 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1cccc2c1C1CC(CN(C)C)ON1c1ccccc1C2 | 10.1016/s0960-894x(01)00721-1 | ||
| 155554175 | 175120 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4581995 | 175120 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2019.126712 | ||
| 9904236 | 13962 | 16 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 295 | 0 | 1 | 3 | 3.7 | O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| CHEMBL1197564 | 13962 | 16 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 295 | 0 | 1 | 3 | 3.7 | O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| 9904236 | 13962 | 16 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 295 | 0 | 1 | 3 | 3.7 | O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| CHEMBL1197564 | 13962 | 16 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 295 | 0 | 1 | 3 | 3.7 | O=C1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| 118162109 | 185664 | 6 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 447 | 8 | 3 | 9 | 3.1 | CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1 | 10.1021/acs.jmedchem.1c00388 | ||
| CHEMBL4873647 | 185664 | 6 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 447 | 8 | 3 | 9 | 3.1 | CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1 | 10.1021/acs.jmedchem.1c00388 | ||
| 736282 | 77786 | 11 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 4.2 | CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL2103769 | 77786 | 11 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 4.2 | CN1[C@H](CC(=O)c2ccccc2)CCC[C@@H]1C[C@H](O)c1ccccc1 | 10.1021/jm300671m | ||
| 13726595 | 99112 | 0 | None | - | 0 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 299 | 3 | 0 | 4 | 2.1 | CN(C)CC[C@H]1CN(C)C(=S)c2cc(Cl)cnc2O1 | 10.1021/jm00108a012 | ||
| CHEMBL283760 | 99112 | 0 | None | - | 0 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 299 | 3 | 0 | 4 | 2.1 | CN(C)CC[C@H]1CN(C)C(=S)c2cc(Cl)cnc2O1 | 10.1021/jm00108a012 | ||
| 2726 | 906 | 64 | None | -2 | 72 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm400856t | ||
| 621 | 906 | 64 | None | -2 | 72 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm400856t | ||
| 83 | 906 | 64 | None | -2 | 72 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm400856t | ||
| CHEMBL71 | 906 | 64 | None | -2 | 72 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm400856t | ||
| DB00477 | 906 | 64 | None | -2 | 72 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm400856t | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm030936t | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm030936t | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm030936t | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm030936t | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm030936t | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm030936t | ||
| 10026300 | 167271 | 15 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 2 | 0 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
| CHEMBL430798 | 167271 | 15 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 2 | 0 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
| 10141470 | 123040 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 6.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL361805 | 123040 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 6.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 44392633 | 65245 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 9 | 1 | 4 | 6.1 | CCCCn1cc(C2CCN(CCOc3cc(Cl)ccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL183168 | 65245 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 9 | 1 | 4 | 6.1 | CCCCn1cc(C2CCN(CCOc3cc(Cl)ccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 9932752 | 141451 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 436 | 8 | 1 | 4 | 5.1 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL387391 | 141451 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 436 | 8 | 1 | 4 | 5.1 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| 45485061 | 197076 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 489 | 5 | 2 | 5 | 5.0 | Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1 | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL583014 | 197076 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 489 | 5 | 2 | 5 | 5.0 | Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)n1 | 10.1016/j.bmcl.2009.09.003 | ||
| 45269073 | 194714 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 563 | 7 | 1 | 9 | 3.7 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL562676 | 194714 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 563 | 7 | 1 | 9 | 3.7 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 45269070 | 194941 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 493 | 5 | 1 | 9 | 2.2 | Cn1c(N2CCN(CCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL564168 | 194941 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 493 | 5 | 1 | 9 | 2.2 | Cn1c(N2CCN(CCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 4601 | 205020 | 29 | None | -1 | 17 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | nan | ||
| CHEMBL1201023 | 205020 | 29 | None | -1 | 17 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | nan | ||
| CHEMBL900 | 205020 | 29 | None | -1 | 17 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | nan | ||
| 10226501 | 137348 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 7 | 1 | 5 | 5.8 | COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| CHEMBL376202 | 137348 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 460 | 7 | 1 | 5 | 5.8 | COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| 2284 | 3133 | 27 | None | -10 | 28 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| 4926 | 3133 | 27 | None | -10 | 28 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| 7281 | 3133 | 27 | None | -10 | 28 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| CHEMBL564 | 3133 | 27 | None | -10 | 28 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| DB00420 | 3133 | 27 | None | -10 | 28 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1021/jm300671m | ||
| 1197 | 88 | 113 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 122 | 2 | 1 | 2 | 0.6 | NCCc1ccccn1 | 10.1021/jm030936t | ||
| 75919 | 88 | 113 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 122 | 2 | 1 | 2 | 0.6 | NCCc1ccccn1 | 10.1021/jm030936t | ||
| CHEMBL32813 | 88 | 113 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 122 | 2 | 1 | 2 | 0.6 | NCCc1ccccn1 | 10.1021/jm030936t | ||
| 10890691 | 44464 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 262 | 12 | 1 | 2 | 4.5 | NCCCCCCCCCCCCc1cccnc1 | 10.1021/jm030936t | ||
| CHEMBL152122 | 44464 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 262 | 12 | 1 | 2 | 4.5 | NCCCCCCCCCCCCc1cccnc1 | 10.1021/jm030936t | ||
| 11288570 | 48735 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 265 | 13 | 2 | 2 | 4.2 | NCCCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL156071 | 48735 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 265 | 13 | 2 | 2 | 4.2 | NCCCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 2142 | 3047 | 54 | None | -7585 | 36 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | 10.1021/jm300671m | ||
| 4920903 | 3047 | 54 | None | -7585 | 36 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | 10.1021/jm300671m | ||
| 502 | 3047 | 54 | None | -7585 | 36 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | 10.1021/jm300671m | ||
| 5775 | 3047 | 54 | None | -7585 | 36 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | 10.1021/jm300671m | ||
| CHEMBL597 | 3047 | 54 | None | -7585 | 36 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | 10.1021/jm300671m | ||
| DB00692 | 3047 | 54 | None | -7585 | 36 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | 10.1021/jm300671m | ||
| 9802248 | 165690 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 420 | 9 | 1 | 4 | 5.4 | CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL426786 | 165690 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 420 | 9 | 1 | 4 | 5.4 | CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 14762597 | 4277 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 392 | 4 | 2 | 3 | 3.4 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1F | 10.1021/jm00173a011 | ||
| CHEMBL101029 | 4277 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 392 | 4 | 2 | 3 | 3.4 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1F | 10.1021/jm00173a011 | ||
| 54582401 | 61669 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 533 | 7 | 1 | 9 | 2.3 | Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774493 | 61669 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 533 | 7 | 1 | 9 | 2.3 | Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 54583384 | 61670 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 547 | 7 | 1 | 9 | 2.9 | CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1CO2 | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774494 | 61670 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 547 | 7 | 1 | 9 | 2.9 | CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1CO2 | 10.1016/j.bmc.2011.03.003 | ||
| 11071079 | 110104 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
| CHEMBL325516 | 110104 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| 135398745 | 2869 | 108 | None | -1 | 65 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1073/pnas.0611417104 | ||
| 47 | 2869 | 108 | None | -1 | 65 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1073/pnas.0611417104 | ||
| CHEMBL715 | 2869 | 108 | None | -1 | 65 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1073/pnas.0611417104 | ||
| DB00334 | 2869 | 108 | None | -1 | 65 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1073/pnas.0611417104 | ||
| 44461622 | 204227 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 4.2 | CCN(CC)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL84293 | 204227 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 4.2 | CCN(CC)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 11476077 | 135884 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.5 | CCOCCn1cc(C2CCN(Cc3cccc(OCC(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL373534 | 135884 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.5 | CCOCCn1cc(C2CCN(Cc3cccc(OCC(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 14762603 | 4132 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 380 | 5 | 1 | 5 | 2.7 | O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| CHEMBL100169 | 4132 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 380 | 5 | 1 | 5 | 2.7 | O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| 14762570 | 4223 | 3 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 368 | 7 | 1 | 5 | 2.1 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| CHEMBL100695 | 4223 | 3 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 368 | 7 | 1 | 5 | 2.1 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| 771426 | 4318 | 16 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 341 | 6 | 1 | 3 | 3.0 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1F | 10.1021/jm00173a011 | ||
| CHEMBL101312 | 4318 | 16 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 341 | 6 | 1 | 3 | 3.0 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1F | 10.1021/jm00173a011 | ||
| 14762602 | 4107 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 335 | 4 | 1 | 3 | 2.8 | O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| CHEMBL100064 | 4107 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 335 | 4 | 1 | 3 | 2.8 | O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| 3151 | 1434 | 93 | None | -41 | 26 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| 945 | 1434 | 93 | None | -41 | 26 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| 965 | 1434 | 93 | None | -41 | 26 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| CHEMBL219916 | 1434 | 93 | None | -41 | 26 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| DB01184 | 1434 | 93 | None | -41 | 26 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| 54581387 | 61682 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 528 | 6 | 1 | 7 | 2.8 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774506 | 61682 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 528 | 6 | 1 | 7 | 2.8 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 44392585 | 122097 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 528 | 8 | 1 | 5 | 7.0 | O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL360270 | 122097 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 528 | 8 | 1 | 5 | 7.0 | O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| 2247 | 502 | 77 | None | -4 | 41 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| 249 | 502 | 77 | None | -4 | 41 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| 2603 | 502 | 77 | None | -4 | 41 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| CHEMBL296419 | 502 | 77 | None | -4 | 41 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| DB00637 | 502 | 77 | None | -4 | 41 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| 44319119 | 106484 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 324 | 3 | 0 | 4 | 3.4 | COc1ccc2c(c1)C1CC(CN(C)C)ON1c1ccccc1C2 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL315044 | 106484 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 324 | 3 | 0 | 4 | 3.4 | COc1ccc2c(c1)C1CC(CN(C)C)ON1c1ccccc1C2 | 10.1016/s0960-894x(01)00721-1 | ||
| 9823337 | 136740 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 418 | 8 | 1 | 4 | 5.0 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL375208 | 136740 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 418 | 8 | 1 | 4 | 5.0 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CC3CC3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 11362693 | 141080 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 440 | 9 | 1 | 5 | 4.4 | COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| CHEMBL385133 | 141080 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 440 | 9 | 1 | 5 | 4.4 | COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| 54581386 | 61666 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 505 | 6 | 1 | 9 | 2.0 | Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774490 | 61666 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 505 | 6 | 1 | 9 | 2.0 | Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 9889247 | 84337 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL223024 | 84337 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 10478188 | 122427 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 436 | 9 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL360712 | 122427 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 436 | 9 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 5624 | 32474 | 12 | None | -5 | 10 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 520 | 5 | 1 | 8 | 4.2 | Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 | nan | ||
| CHEMBL1203324 | 32474 | 12 | None | -5 | 10 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 520 | 5 | 1 | 8 | 4.2 | Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 | nan | ||
| CHEMBL141343 | 32474 | 12 | None | -5 | 10 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 520 | 5 | 1 | 8 | 4.2 | Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 | nan | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1021/jm501535r | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1021/jm501535r | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1021/jm501535r | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1021/jm501535r | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1021/jm501535r | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1021/jm501535r | ||
| 44318834 | 105671 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3cccc(Cl)c3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL313604 | 105671 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3cccc(Cl)c3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 44318820 | 204319 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1ccc2c(c1)Cc1ccccc1N1OC(CN(C)C)CC21 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL85155 | 204319 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1ccc2c(c1)Cc1ccccc1N1OC(CN(C)C)CC21 | 10.1016/s0960-894x(01)00721-1 | ||
| 2865 | 4079 | 67 | None | -1047 | 53 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 59 | 4079 | 67 | None | -1047 | 53 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 60854 | 4079 | 67 | None | -1047 | 53 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| CHEMBL708 | 4079 | 67 | None | -1047 | 53 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| DB00246 | 4079 | 67 | None | -1047 | 53 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 10279311 | 83933 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 512 | 7 | 1 | 5 | 6.6 | COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4cc(F)ccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| CHEMBL221730 | 83933 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 512 | 7 | 1 | 5 | 6.6 | COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4cc(F)ccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| 11212029 | 84196 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 4.5 | COCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| CHEMBL222142 | 84196 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 4.5 | COCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| 9889248 | 84306 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL222853 | 84306 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 11329754 | 141450 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 10 | 1 | 5 | 5.4 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(Br)ccc21 | 10.1021/jm0498203 | ||
| CHEMBL387390 | 141450 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 10 | 1 | 5 | 5.4 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(Br)ccc21 | 10.1021/jm0498203 | ||
| 1305 | 508 | 10 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 4.1 | O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| 9934033 | 508 | 10 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 4.1 | O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL182150 | 508 | 10 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 4.1 | O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| 54586253 | 61671 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 7 | 1 | 9 | 3.1 | Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774495 | 61671 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 7 | 1 | 9 | 3.1 | Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 2.8 | pIC50 | = | 2.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 2.8 | pIC50 | = | 2.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 2.8 | pIC50 | = | 2.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 2.8 | pIC50 | = | 2.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 2.8 | pIC50 | = | 2.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 44461613 | 103746 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 350 | 4 | 0 | 3 | 5.0 | CC(C)N(CC1CC2c3ccccc3Cc3ccccc3N2O1)C(C)C | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL309904 | 103746 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 350 | 4 | 0 | 3 | 5.0 | CC(C)N(CC1CC2c3ccccc3Cc3ccccc3N2O1)C(C)C | 10.1016/s0960-894x(01)00721-1 | ||
| 14762593 | 4611 | 8 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 6 | 1 | 2 | 4.0 | O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| CHEMBL103303 | 4611 | 8 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 6 | 1 | 2 | 4.0 | O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| 54587282 | 61683 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 5 | 1 | 7 | 2.9 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774507 | 61683 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 5 | 1 | 7 | 2.9 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 14762579 | 4332 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 6 | 1 | 2 | 3.4 | O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 | 10.1021/jm00173a011 | ||
| CHEMBL101388 | 4332 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 6 | 1 | 2 | 3.4 | O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 | 10.1021/jm00173a011 | ||
| 11351801 | 83931 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 466 | 11 | 1 | 6 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(OC)ccc21 | 10.1021/jm0498203 | ||
| CHEMBL221716 | 83931 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 466 | 11 | 1 | 6 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(OC)ccc21 | 10.1021/jm0498203 | ||
| 12488 | 1627 | 51 | None | -2 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| 941361 | 1627 | 51 | None | -2 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| CHEMBL30008 | 1627 | 51 | None | -2 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| DB04841 | 1627 | 51 | None | -2 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm030936t | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm030936t | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm030936t | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm030936t | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm030936t | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm030936t | ||
| 4098 | 32289 | 24 | None | 1 | 11 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | nan | ||
| CHEMBL1255739 | 32289 | 24 | None | 1 | 11 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | nan | ||
| CHEMBL1411979 | 32289 | 24 | None | 1 | 11 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | nan | ||
| 44345317 | 112568 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 2 | 0 | 4 | 2.8 | CN(C)CC1CC2c3cccnc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
| CHEMBL331188 | 112568 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 295 | 2 | 0 | 4 | 2.8 | CN(C)CC1CC2c3cccnc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
| 10246054 | 106062 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 330 | 2 | 0 | 3 | 3.7 | CN(C)CC1CC2c3cc(F)ccc3Cc3ccc(F)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL314107 | 106062 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 330 | 2 | 0 | 3 | 3.7 | CN(C)CC1CC2c3cc(F)ccc3Cc3ccc(F)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 1588 | 2294 | 24 | None | -51 | 43 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| 28864 | 2294 | 24 | None | -51 | 43 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| 43 | 2294 | 24 | None | -51 | 43 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| CHEMBL157138 | 2294 | 24 | None | -51 | 43 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| DB00589 | 2294 | 24 | None | -51 | 43 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| 45485062 | 195492 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 367 | 5 | 2 | 5 | 3.3 | Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1 | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL567993 | 195492 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 367 | 5 | 2 | 5 | 3.3 | Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1 | 10.1016/j.bmcl.2009.09.003 | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 14762598 | 4249 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 374 | 4 | 2 | 3 | 3.2 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| CHEMBL100865 | 4249 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 374 | 4 | 2 | 3 | 3.2 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| 4601 | 205020 | 29 | None | - | 17 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL1201023 | 205020 | 29 | None | - | 17 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL900 | 205020 | 29 | None | - | 17 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | 10.1021/jm300671m | ||
| 11113605 | 10407 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
| CHEMBL116735 | 10407 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
| 2031 | 119927 | 30 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 311 | 8 | 0 | 3 | 3.7 | CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL353846 | 119927 | 30 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 311 | 8 | 0 | 3 | 3.7 | CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm300671m | ||
| 2726 | 906 | 64 | None | -2 | 72 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| 621 | 906 | 64 | None | -2 | 72 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| 83 | 906 | 64 | None | -2 | 72 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| CHEMBL71 | 906 | 64 | None | -2 | 72 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| DB00477 | 906 | 64 | None | -2 | 72 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| 155536195 | 171598 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 504 | 7 | 1 | 5 | 5.6 | CCOc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4473399 | 171598 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 504 | 7 | 1 | 5 | 5.6 | CCOc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 23027035 | 196870 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 367 | 5 | 2 | 5 | 3.3 | Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1 | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL578170 | 196870 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 367 | 5 | 2 | 5 | 3.3 | Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1 | 10.1016/j.bmcl.2009.09.003 | ||
| 44392612 | 66352 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 474 | 9 | 1 | 6 | 5.2 | COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL185454 | 66352 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 474 | 9 | 1 | 6 | 5.2 | COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| 126963284 | 144241 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 311 | 1 | 1 | 3 | 4.2 | CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| CHEMBL3909134 | 144241 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 311 | 1 | 1 | 3 | 4.2 | CO[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| 121237834 | 146826 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 297 | 0 | 2 | 3 | 3.5 | O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| CHEMBL3929465 | 146826 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 297 | 0 | 2 | 3 | 3.5 | O[C@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| 14762588 | 4294 | 2 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 368 | 7 | 1 | 5 | 2.7 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| CHEMBL101122 | 4294 | 2 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 368 | 7 | 1 | 5 | 2.7 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 14762599 | 4133 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 419 | 5 | 2 | 5 | 3.1 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| CHEMBL100170 | 4133 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 419 | 5 | 2 | 5 | 3.1 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm00173a011 | ||
| 2712 | 903 | 33 | None | -5 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| 3370 | 903 | 33 | None | -5 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| 594 | 903 | 33 | None | -5 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| CHEMBL451 | 903 | 33 | None | -5 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| DB00475 | 903 | 33 | None | -5 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| 10907460 | 9735 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
| CHEMBL113956 | 9735 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
| 11340290 | 64033 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 466 | 11 | 1 | 6 | 4.6 | CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL181278 | 64033 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 466 | 11 | 1 | 6 | 4.6 | CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 11282005 | 65735 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL183706 | 65735 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 11730467 | 10925 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
| CHEMBL117537 | 10925 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | ||
| 54586257 | 61681 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 514 | 6 | 1 | 7 | 2.5 | Cn1c(N2CCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774505 | 61681 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 514 | 6 | 1 | 7 | 2.5 | Cn1c(N2CCN(CC/C=C3/c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 11430513 | 84208 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.5 | CCOCCn1cc(C2CCN(Cc3ccccc3OCC(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL222217 | 84208 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.5 | CCOCCn1cc(C2CCN(Cc3ccccc3OCC(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 19426632 | 204143 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 266 | 1 | 1 | 3 | 2.8 | NCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL83731 | 204143 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 266 | 1 | 1 | 3 | 2.8 | NCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 1195 | 47 | 5 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 221 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)Cl | 10.1021/jm030936t | ||
| 14827778 | 47 | 5 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 221 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)Cl | 10.1021/jm030936t | ||
| CHEMBL287052 | 47 | 5 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 221 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)Cl | 10.1021/jm030936t | ||
| 11346501 | 48000 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 279 | 14 | 2 | 2 | 4.6 | NCCCCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL155314 | 48000 | 1 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 279 | 14 | 2 | 2 | 4.6 | NCCCCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 11264275 | 118963 | 2 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 209 | 9 | 2 | 2 | 2.6 | NCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL345185 | 118963 | 2 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 209 | 9 | 2 | 2 | 2.6 | NCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 1164 | 1600 | 25 | None | - | 11 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm300671m | ||
| 1626 | 1600 | 25 | None | - | 11 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm300671m | ||
| 3345 | 1600 | 25 | None | - | 11 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm300671m | ||
| CHEMBL596 | 1600 | 25 | None | - | 11 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm300671m | ||
| DB00813 | 1600 | 25 | None | - | 11 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | 10.1021/jm300671m | ||
| 44290349 | 177962 | 0 | None | 131 | 2 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 2.1 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1 | 10.1021/jm00159a017 | ||
| CHEMBL46683 | 177962 | 0 | None | 131 | 2 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 2.1 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1 | 10.1021/jm00159a017 | ||
| 44319120 | 204064 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3cccc(F)c3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL82966 | 204064 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3cccc(F)c3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 10381889 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
| CHEMBL315772 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
| 10381889 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL315772 | 106586 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 328 | 2 | 0 | 3 | 4.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 44318454 | 204290 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL84931 | 204290 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 2286 | 3134 | 48 | None | -2 | 29 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| 4927 | 3134 | 48 | None | -2 | 29 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| 7282 | 3134 | 48 | None | -2 | 29 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| CHEMBL643 | 3134 | 48 | None | -2 | 29 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| DB01069 | 3134 | 48 | None | -2 | 29 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| 155518920 | 169756 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4446961 | 169756 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 155541322 | 172439 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 6 | 1 | 5 | 5.4 | CC(=O)c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4518271 | 172439 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 6 | 1 | 5 | 5.4 | CC(=O)c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 10114407 | 122810 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 5.4 | COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)cc1C(=O)O | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL361625 | 122810 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 5.4 | COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)cc1C(=O)O | 10.1016/j.bmcl.2004.12.008 | ||
| 44332016 | 4179 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 261 | 0 | 1 | 2 | 2.4 | ClN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL100442 | 4179 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 261 | 0 | 1 | 2 | 2.4 | ClN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| 13726483 | 94811 | 1 | None | - | 0 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 265 | 3 | 0 | 4 | 1.4 | CN(C)CC[C@H]1CN(C)C(=S)c2cccnc2O1 | 10.1021/jm00108a012 | ||
| CHEMBL25622 | 94811 | 1 | None | - | 0 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 265 | 3 | 0 | 4 | 1.4 | CN(C)CC[C@H]1CN(C)C(=S)c2cccnc2O1 | 10.1021/jm00108a012 | ||
| 44392549 | 65025 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 450 | 10 | 1 | 5 | 5.4 | CCCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL182922 | 65025 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 450 | 10 | 1 | 5 | 5.4 | CCCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 739984 | 106720 | 15 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 2.8 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| CHEMBL316616 | 106720 | 15 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 2.8 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1 | 10.1021/jm00173a011 | ||
| 9822631 | 122444 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.8 | CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL360791 | 122444 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.8 | CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 11202401 | 136583 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 478 | 11 | 1 | 6 | 4.8 | CCOCCn1cc(C2CCN(CCOc3ccc(C(C)=O)cc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL374755 | 136583 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 478 | 11 | 1 | 6 | 4.8 | CCOCCn1cc(C2CCN(CCOc3ccc(C(C)=O)cc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| 10369004 | 13576 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 7 | 0 | 8 | 2.5 | Cn1c(=O)c2c(ncn2CCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n(C)c1=O | 10.1021/jm00020a018 | ||
| CHEMBL1194812 | 13576 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 7 | 0 | 8 | 2.5 | Cn1c(=O)c2c(ncn2CCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n(C)c1=O | 10.1021/jm00020a018 | ||
| CHEMBL553331 | 13576 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 508 | 7 | 0 | 8 | 2.5 | Cn1c(=O)c2c(ncn2CCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n(C)c1=O | 10.1021/jm00020a018 | ||
| 11166846 | 83885 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 450 | 10 | 1 | 5 | 4.9 | CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL221462 | 83885 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 450 | 10 | 1 | 5 | 4.9 | CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 11238716 | 83876 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 592 | 10 | 1 | 5 | 6.2 | CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL221414 | 83876 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 592 | 10 | 1 | 5 | 6.2 | CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 10160717 | 167834 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 5.2 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL434709 | 167834 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 5.2 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm991005d | ||
| 45267326 | 194292 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 535 | 7 | 1 | 9 | 2.9 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL559665 | 194292 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 535 | 7 | 1 | 9 | 2.9 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 45268181 | 194970 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 521 | 6 | 1 | 9 | 3.0 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL564370 | 194970 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 521 | 6 | 1 | 9 | 3.0 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9704457 | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9704457 | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9704457 | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9704457 | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9704457 | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 126963283 | 160416 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 311 | 1 | 1 | 3 | 4.2 | CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| CHEMBL4115677 | 160416 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 311 | 1 | 1 | 3 | 4.2 | CO[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| 11638166 | 8063 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | CC(c1ccncc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091790 | 8063 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | CC(c1ccncc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 11335478 | 160418 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 297 | 0 | 2 | 3 | 3.5 | O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| CHEMBL4115693 | 160418 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 297 | 0 | 2 | 3 | 3.5 | O[C@@H]1Cc2ccccc2C(=C2CCNCC2)c2ccsc21 | nan | ||
| 9802248 | 165690 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 420 | 9 | 1 | 4 | 5.4 | CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL426786 | 165690 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 420 | 9 | 1 | 4 | 5.4 | CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 2274 | 3124 | 53 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 4917 | 3124 | 53 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 7279 | 3124 | 53 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| CHEMBL728 | 3124 | 53 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| DB00433 | 3124 | 53 | None | -3 | 32 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 14842833 | 92871 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 275 | 5 | 0 | 3 | 3.2 | CN(C)CCC(c1ccccn1)c1ccc(Cl)cn1 | 10.1021/jm00108a012 | ||
| CHEMBL24517 | 92871 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 275 | 5 | 0 | 3 | 3.2 | CN(C)CCC(c1ccccn1)c1ccc(Cl)cn1 | 10.1021/jm00108a012 | ||
| 44392620 | 126302 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 524 | 9 | 1 | 6 | 6.4 | COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL365450 | 126302 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 524 | 9 | 1 | 6 | 6.4 | COc1ccc(C(=O)O)c(OCCN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| 10003369 | 83919 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 8 | 1 | 5 | 4.5 | COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| CHEMBL221678 | 83919 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 8 | 1 | 5 | 4.5 | COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| 11333854 | 51329 | 1 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 237 | 11 | 2 | 2 | 3.4 | NCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL158352 | 51329 | 1 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 237 | 11 | 2 | 2 | 3.4 | NCCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 11241807 | 50737 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 234 | 10 | 1 | 2 | 3.7 | NCCCCCCCCCCc1cccnc1 | 10.1021/jm030936t | ||
| CHEMBL157842 | 50737 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 234 | 10 | 1 | 2 | 3.7 | NCCCCCCCCCCc1cccnc1 | 10.1021/jm030936t | ||
| 11253315 | 121451 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 234 | 10 | 1 | 2 | 3.7 | NCCCCCCCCCCc1ccncc1 | 10.1021/jm030936t | ||
| CHEMBL359122 | 121451 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 234 | 10 | 1 | 2 | 3.7 | NCCCCCCCCCCc1ccncc1 | 10.1021/jm030936t | ||
| 54586252 | 61668 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 519 | 7 | 1 | 9 | 2.0 | Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774492 | 61668 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 519 | 7 | 1 | 9 | 2.0 | Cn1c(N2CCN(CCCN3c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 127049862 | 139727 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 8 | 1 | 5 | 4.4 | CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1016/j.bmcl.2016.04.087 | ||
| CHEMBL3805559 | 139727 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 8 | 1 | 5 | 4.4 | CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | 10.1016/j.bmcl.2016.04.087 | ||
| 44461800 | 203586 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.2 | c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCOCC3)CC21 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL79249 | 203586 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.2 | c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCOCC3)CC21 | 10.1016/s0960-894x(01)00721-1 | ||
| 1427 | 1982 | 50 | None | -5 | 26 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm400856t | ||
| 357 | 1982 | 50 | None | -5 | 26 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm400856t | ||
| 3696 | 1982 | 50 | None | -5 | 26 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm400856t | ||
| CHEMBL11 | 1982 | 50 | None | -5 | 26 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm400856t | ||
| DB00458 | 1982 | 50 | None | -5 | 26 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1021/jm400856t | ||
| 6075 | 149575 | 36 | None | 2 | 16 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 310 | 2 | 0 | 3 | 4.6 | CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 | nan | ||
| CHEMBL395110 | 149575 | 36 | None | 2 | 16 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 310 | 2 | 0 | 3 | 4.6 | CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 | nan | ||
| 155545724 | 172899 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 526 | 6 | 1 | 5 | 5.5 | COc1c(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)ccc(F)c1F | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4529928 | 172899 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 526 | 6 | 1 | 5 | 5.5 | COc1c(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)ccc(F)c1F | 10.1016/j.bmcl.2019.126712 | ||
| 44392599 | 64844 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 5.5 | CCCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL182474 | 64844 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 5.5 | CCCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| 11785584 | 136441 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.5 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL374459 | 136441 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.5 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| 22322323 | 194343 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 1 | 7 | 2.7 | Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL560120 | 194343 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 1 | 7 | 2.7 | Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 3191 | 102385 | 93 | None | 2 | 25 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
| CHEMBL305660 | 102385 | 93 | None | 2 | 25 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
| 155549722 | 173277 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 494 | 5 | 1 | 4 | 5.8 | OC(COc1ccccc1Cl)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4539056 | 173277 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 494 | 5 | 1 | 4 | 5.8 | OC(COc1ccccc1Cl)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 10894144 | 110070 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 3.5 | N#Cc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 | 10.1021/jm010878g | ||
| CHEMBL325258 | 110070 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 3.5 | N#Cc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1 | 10.1021/jm010878g | ||
| 3038952 | 108424 | 1 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 241 | 0 | 1 | 2 | 1.8 | CN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL321104 | 108424 | 1 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 241 | 0 | 1 | 2 | 1.8 | CN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| 76319448 | 84964 | 2 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 221 | 4 | 4 | 4 | 0.7 | CC(CO)(CO)Nc1nc2ccccc2[nH]1 | 10.1007/s00044-008-9119-y | ||
| CHEMBL2262478 | 84964 | 2 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 221 | 4 | 4 | 4 | 0.7 | CC(CO)(CO)Nc1nc2ccccc2[nH]1 | 10.1007/s00044-008-9119-y | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| 2812 | 4711 | 96 | None | -28 | 34 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| CHEMBL104 | 4711 | 96 | None | -28 | 34 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| 2600 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00121a022 | ||
| 2608 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00121a022 | ||
| 5405 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00121a022 | ||
| CHEMBL17157 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00121a022 | ||
| DB00342 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00121a022 | ||
| 10141470 | 123040 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 6.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL361805 | 123040 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 6.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccc(Cl)s3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| 153996 | 112171 | 2 | None | - | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1021/jm058225d | ||
| CHEMBL330366 | 112171 | 2 | None | - | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1021/jm058225d | ||
| CHEMBL539021 | 112171 | 2 | None | - | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1021/jm058225d | ||
| 19426644 | 106690 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 320 | 2 | 0 | 3 | 3.9 | c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCCC3)CC21 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL316438 | 106690 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 320 | 2 | 0 | 3 | 3.9 | c1ccc2c(c1)Cc1ccccc1N1OC(CN3CCCC3)CC21 | 10.1016/s0960-894x(01)00721-1 | ||
| 1201549 | 590 | 22 | None | -1 | 20 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| 333 | 590 | 22 | None | -1 | 20 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| 7601 | 590 | 22 | None | -1 | 20 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL1201203 | 590 | 22 | None | -1 | 20 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL438151 | 590 | 22 | None | -1 | 20 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| DB00245 | 590 | 22 | None | -1 | 20 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 45269436 | 194981 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 5 | 0 | 5 | 4.3 | CN(C1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL564446 | 194981 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 5 | 0 | 5 | 4.3 | CN(C1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 135 | 2496 | 38 | None | -1 | 57 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1016/s0960-894x(01)00721-1 | ||
| 2284 | 3133 | 27 | None | 1 | 28 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| 4926 | 3133 | 27 | None | 1 | 28 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| 7281 | 3133 | 27 | None | 1 | 28 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| CHEMBL564 | 3133 | 27 | None | 1 | 28 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| DB00420 | 3133 | 27 | None | 1 | 28 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| 11539632 | 70217 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | ||
| CHEMBL194837 | 70217 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 8 | 1 | 5 | 4.8 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | 10.1021/jm050103y | ||
| 155568607 | 175538 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccccc1OC[C@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4591702 | 175538 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccccc1OC[C@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 277 | 1274 | 55 | None | -2 | 45 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| 2913 | 1274 | 55 | None | -2 | 45 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| 765 | 1274 | 55 | None | -2 | 45 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| CHEMBL516 | 1274 | 55 | None | -2 | 45 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| DB00434 | 1274 | 55 | None | -2 | 45 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 44319133 | 106458 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3cc(F)ccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL314885 | 106458 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 312 | 2 | 0 | 3 | 3.5 | CN(C)CC1CC2c3cc(F)ccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 10103 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| 133017 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| 2413 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| CHEMBL91397 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| DB11614 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm058225d | ||
| 13726485 | 90993 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 265 | 3 | 0 | 4 | 1.4 | CN(C)CC[C@@H]1CN(C)C(=S)c2cccnc2O1 | 10.1021/jm00108a012 | ||
| CHEMBL24031 | 90993 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 265 | 3 | 0 | 4 | 1.4 | CN(C)CC[C@@H]1CN(C)C(=S)c2cccnc2O1 | 10.1021/jm00108a012 | ||
| 11247290 | 136180 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 424 | 8 | 1 | 4 | 4.9 | CCOCCn1cc(C2CCN(Cc3ccc(F)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL374059 | 136180 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 424 | 8 | 1 | 4 | 4.9 | CCOCCn1cc(C2CCN(Cc3ccc(F)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 9918576 | 205606 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1021/jm058225d | ||
| CHEMBL93556 | 205606 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1021/jm058225d | ||
| 10420190 | 205033 | 0 | None | - | 3 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 195 | 8 | 2 | 2 | 2.3 | NCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL90063 | 205033 | 0 | None | - | 3 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 195 | 8 | 2 | 2 | 2.3 | NCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 10660 | 14298 | 55 | None | 2 | 12 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 7 | 3.0 | CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O | nan | ||
| CHEMBL1200406 | 14298 | 55 | None | 2 | 12 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 7 | 3.0 | CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O | nan | ||
| 2771 | 193347 | 67 | None | -2 | 26 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | nan | ||
| CHEMBL1200781 | 193347 | 67 | None | -2 | 26 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | nan | ||
| CHEMBL549 | 193347 | 67 | None | -2 | 26 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | nan | ||
| 11259138 | 84588 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.5 | CCOCCn1cc(C2CCN(Cc3ccc(OCC(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL223882 | 84588 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.5 | CCOCCn1cc(C2CCN(Cc3ccc(OCC(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 45272487 | 194728 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 7 | 1 | 9 | 3.4 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(/C=C\C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL562792 | 194728 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 7 | 1 | 9 | 3.4 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(/C=C\C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 54582402 | 61679 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 5 | 1 | 8 | 2.3 | Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774503 | 61679 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 5 | 1 | 8 | 2.3 | Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 11211919 | 84329 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.8 | CCOCCn1cc(C2CCN(Cc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL222984 | 84329 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.8 | CCOCCn1cc(C2CCN(Cc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 10205121 | 66359 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 6 | 1 | 4 | 6.5 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL185489 | 66359 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 6 | 1 | 4 | 6.5 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| 11340290 | 64033 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 466 | 11 | 1 | 6 | 4.6 | CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL181278 | 64033 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 466 | 11 | 1 | 6 | 4.6 | CCOCCn1cc(C2CCN(CCOc3cc(OC)ccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 14762564 | 4246 | 2 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 449 | 6 | 1 | 3 | 2.8 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1I | 10.1021/jm00173a011 | ||
| CHEMBL100858 | 4246 | 2 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 449 | 6 | 1 | 3 | 2.8 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1I | 10.1021/jm00173a011 | ||
| 11363750 | 84207 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 484 | 8 | 1 | 4 | 5.5 | CCOCCn1cc(C2CCN(Cc3cc(C(=O)O)ccc3Br)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL222214 | 84207 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 484 | 8 | 1 | 4 | 5.5 | CCOCCn1cc(C2CCN(Cc3cc(C(=O)O)ccc3Br)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 45270753 | 193729 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 521 | 7 | 1 | 9 | 3.0 | Cn1c(N2CCN(CCCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL552057 | 193729 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 521 | 7 | 1 | 9 | 3.0 | Cn1c(N2CCN(CCCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 11659592 | 8059 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091777 | 8059 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 10161929 | 136663 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 9 | 1 | 6 | 4.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3OCCO3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL374869 | 136663 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 9 | 1 | 6 | 4.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3OCCO3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 149227688 | 174057 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 544 | 6 | 1 | 5 | 6.1 | OC(COc1ccccc1OC(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4557928 | 174057 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 544 | 6 | 1 | 5 | 6.1 | OC(COc1ccccc1OC(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 44566054 | 186558 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 350 | 9 | 0 | 3 | 5.1 | CCN(CC)CCCCCCn1c2ccccc2c(=O)c2ccccc21 | 10.1128/aac.00669-07 | ||
| CHEMBL491889 | 186558 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 350 | 9 | 0 | 3 | 5.1 | CCN(CC)CCCCCCn1c2ccccc2c(=O)c2ccccc21 | 10.1128/aac.00669-07 | ||
| 213 | 3792 | 50 | None | -4 | 43 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| 2717 | 3792 | 50 | None | -4 | 43 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| 5533 | 3792 | 50 | None | -4 | 43 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| CHEMBL621 | 3792 | 50 | None | -4 | 43 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| DB00656 | 3792 | 50 | None | -4 | 43 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| 44332061 | 4349 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 257 | 1 | 1 | 3 | 1.8 | CON1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL101490 | 4349 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 257 | 1 | 1 | 3 | 1.8 | CON1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| 44392588 | 66320 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 7 | 1 | 5 | 6.5 | COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)cc1C(=O)O | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL185289 | 66320 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 7 | 1 | 5 | 6.5 | COc1ccc(CN2CCC(c3cn(Cc4ccc(Cl)s4)c4ccccc34)CC2)cc1C(=O)O | 10.1016/j.bmcl.2004.12.008 | ||
| 10139592 | 84580 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL223837 | 84580 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| 45270750 | 193635 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 6 | 1 | 9 | 2.6 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL551457 | 193635 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 6 | 1 | 9 | 2.6 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 44319098 | 204071 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 362 | 2 | 0 | 3 | 4.4 | CN(C)CC1CC2c3cccc(C(F)(F)F)c3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL83073 | 204071 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 362 | 2 | 0 | 3 | 4.4 | CN(C)CC1CC2c3cccc(C(F)(F)F)c3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 44332031 | 206373 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 272 | 1 | 1 | 3 | 1.4 | O=[N+]([O-])N1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL97938 | 206373 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 272 | 1 | 1 | 3 | 1.4 | O=[N+]([O-])N1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| 6726 | 1254 | 46 | None | 3 | 13 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 7151 | 1254 | 46 | None | 3 | 13 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 749 | 1254 | 46 | None | 3 | 13 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL648 | 1254 | 46 | None | 3 | 13 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| DB01176 | 1254 | 46 | None | 3 | 13 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| 2762 | 3802 | 28 | None | -9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 10.1021/jm030936t | ||
| 5587 | 3802 | 28 | None | -9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 10.1021/jm030936t | ||
| 7318 | 3802 | 28 | None | -9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 10.1021/jm030936t | ||
| CHEMBL1241 | 3802 | 28 | None | -9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 10.1021/jm030936t | ||
| DB00792 | 3802 | 28 | None | -9 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 10.1021/jm030936t | ||
| 10140544 | 141107 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 9 | 1 | 6 | 4.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3COCCO3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL385311 | 141107 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 9 | 1 | 6 | 4.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CCC3COCCO3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 23027211 | 195574 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 421 | 5 | 2 | 5 | 4.3 | Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1 | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL568400 | 195574 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 421 | 5 | 2 | 5 | 4.3 | Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1 | 10.1016/j.bmcl.2009.09.003 | ||
| 11231249 | 50067 | 1 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 277 | 11 | 1 | 2 | 4.2 | c1nc(CCCCCCCCCCN2CCCC2)c[nH]1 | 10.1021/jm030936t | ||
| CHEMBL157217 | 50067 | 1 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 277 | 11 | 1 | 2 | 4.2 | c1nc(CCCCCCCCCCN2CCCC2)c[nH]1 | 10.1021/jm030936t | ||
| 10264715 | 50127 | 1 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 262 | 12 | 1 | 2 | 4.5 | NCCCCCCCCCCCCc1ccncc1 | 10.1021/jm030936t | ||
| CHEMBL157273 | 50127 | 1 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 262 | 12 | 1 | 2 | 4.5 | NCCCCCCCCCCCCc1ccncc1 | 10.1021/jm030936t | ||
| 11358657 | 44581 | 1 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 305 | 13 | 1 | 2 | 4.9 | c1nc(CCCCCCCCCCCCN2CCCC2)c[nH]1 | 10.1021/jm030936t | ||
| CHEMBL152221 | 44581 | 1 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 305 | 13 | 1 | 2 | 4.9 | c1nc(CCCCCCCCCCCCN2CCCC2)c[nH]1 | 10.1021/jm030936t | ||
| 45270350 | 193404 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 434 | 6 | 0 | 4 | 5.7 | CN(CC1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL549598 | 193404 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 434 | 6 | 0 | 4 | 5.7 | CN(CC1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 155532375 | 171214 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccccc1OC[C@@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4467816 | 171214 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1ccccc1OC[C@@H](O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 155557098 | 173997 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | OC(COc1ccccc1F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4556553 | 173997 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | OC(COc1ccccc1F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 180 | 397 | 50 | None | -1 | 38 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| 200 | 397 | 50 | None | -1 | 38 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| 2160 | 397 | 50 | None | -1 | 38 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| CHEMBL629 | 397 | 50 | None | -1 | 38 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| DB00321 | 397 | 50 | None | -1 | 38 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 11753159 | 542 | 3 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| 7679 | 542 | 3 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| CHEMBL2158814 | 542 | 3 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1021/jm300682j | ||
| 1212 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| 204 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| 3372 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| CHEMBL726 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| DB00623 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| 2337 | 3205 | 72 | None | -1 | 62 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 50 | 3205 | 72 | None | -1 | 62 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 5002 | 3205 | 72 | None | -1 | 62 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| CHEMBL716 | 3205 | 72 | None | -1 | 62 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| DB01224 | 3205 | 72 | None | -1 | 62 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 44189144 | 194291 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 7 | 1 | 9 | 2.5 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL559664 | 194291 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 7 | 1 | 9 | 2.5 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 44189144 | 194291 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 7 | 1 | 9 | 2.5 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL559664 | 194291 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 7 | 1 | 9 | 2.5 | Cn1c(N2CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 155526952 | 170610 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 538 | 5 | 1 | 4 | 5.9 | OC(COc1ccccc1Br)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4458953 | 170610 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 538 | 5 | 1 | 4 | 5.9 | OC(COc1ccccc1Br)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 9822631 | 122444 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.8 | CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL360791 | 122444 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.8 | CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 16722760 | 61667 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 9 | 2.4 | Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774491 | 61667 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 9 | 2.4 | Cn1c(N2CCCN(CCCN3c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 45269933 | 193625 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 518 | 7 | 1 | 8 | 3.5 | Cn1c(C2=CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL551394 | 193625 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 518 | 7 | 1 | 8 | 3.5 | Cn1c(C2=CCN(CCCN3c4ccccc4Sc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 45268186 | 194855 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 563 | 8 | 1 | 9 | 3.9 | CCC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2 | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL563647 | 194855 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 563 | 8 | 1 | 9 | 3.9 | CCC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2 | 10.1016/j.bmcl.2009.03.124 | ||
| 133 | 2460 | 48 | None | -102 | 42 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 1723 | 2460 | 48 | None | -102 | 42 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 28693 | 2460 | 48 | None | -102 | 42 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| CHEMBL19215 | 2460 | 48 | None | -102 | 42 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| DB13520 | 2460 | 48 | None | -102 | 42 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 155544367 | 172802 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 508 | 3 | 0 | 4 | 6.0 | CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC | 10.1021/acs.jmedchem.9b01924 | ||
| CHEMBL4527708 | 172802 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 508 | 3 | 0 | 4 | 6.0 | CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC | 10.1021/acs.jmedchem.9b01924 | ||
| 11385692 | 136525 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL374675 | 136525 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 462 | 8 | 1 | 5 | 5.4 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccoc3)c3cc(F)ccc23)CC1 | 10.1021/jm0498203 | ||
| 14407121 | 59769 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 10 | 1 | 5 | 5.3 | COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm00121a022 | ||
| CHEMBL17390 | 59769 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 10 | 1 | 5 | 5.3 | COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm00121a022 | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2016.04.087 | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2016.04.087 | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2016.04.087 | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2016.04.087 | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2016.04.087 | ||
| 14762566 | 107249 | 7 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 3.0 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Br | 10.1021/jm00173a011 | ||
| CHEMBL319123 | 107249 | 7 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 3.0 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Br | 10.1021/jm00173a011 | ||
| 14842830 | 98529 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 308 | 5 | 0 | 2 | 4.5 | CN(C)CCC(c1ccc(Cl)cc1)c1ccc(Cl)cn1 | 10.1021/jm00108a012 | ||
| CHEMBL279907 | 98529 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 308 | 5 | 0 | 2 | 4.5 | CN(C)CCC(c1ccc(Cl)cc1)c1ccc(Cl)cn1 | 10.1021/jm00108a012 | ||
| 15181802 | 12059 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 7 | 0 | 7 | 3.4 | Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O | 10.1021/jm00020a018 | ||
| CHEMBL1184199 | 12059 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 7 | 0 | 7 | 3.4 | Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O | 10.1021/jm00020a018 | ||
| CHEMBL338611 | 12059 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 7 | 0 | 7 | 3.4 | Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O | 10.1021/jm00020a018 | ||
| 3191 | 102385 | 93 | None | - | 25 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm00020a018 | ||
| CHEMBL305660 | 102385 | 93 | None | - | 25 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm00020a018 | ||
| 3168 | 9172 | 84 | None | -87 | 21 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| CHEMBL1108 | 9172 | 84 | None | -87 | 21 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| 11005810 | 10367 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
| CHEMBL116463 | 10367 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
| 45269062 | 194837 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 8 | 2 | 9 | 3.6 | Cn1c(NCCCN2CCC(CN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL563520 | 194837 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 8 | 2 | 9 | 3.6 | Cn1c(NCCCN2CCC(CN3c4ccccc4Sc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 9954899 | 202758 | 15 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
| CHEMBL72292 | 202758 | 15 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm991005d | ||
| 11189839 | 83917 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 438 | 9 | 1 | 4 | 5.5 | CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| CHEMBL221664 | 83917 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 438 | 9 | 1 | 4 | 5.5 | CCCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| 9954899 | 202758 | 15 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm9704457 | ||
| CHEMBL72292 | 202758 | 15 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1 | 10.1021/jm9704457 | ||
| 44319134 | 204275 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 362 | 2 | 0 | 3 | 4.4 | CN(C)CC1CC2c3c(cccc3C(F)(F)F)Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL84810 | 204275 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 362 | 2 | 0 | 3 | 4.4 | CN(C)CC1CC2c3c(cccc3C(F)(F)F)Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 9979651 | 84338 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 422 | 8 | 1 | 5 | 4.4 | COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL223025 | 84338 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 422 | 8 | 1 | 5 | 4.4 | COCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 10409896 | 65246 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 420 | 8 | 1 | 4 | 5.5 | CCCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL183169 | 65246 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 420 | 8 | 1 | 4 | 5.5 | CCCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 14762590 | 4422 | 1 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 7 | 1 | 2 | 4.5 | CCc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| CHEMBL101973 | 4422 | 1 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 7 | 1 | 2 | 4.5 | CCc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| 11811722 | 9970 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 413 | 5 | 1 | 4 | 4.4 | O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2 | 10.1021/jm010878g | ||
| CHEMBL115280 | 9970 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 413 | 5 | 1 | 4 | 4.4 | O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2 | 10.1021/jm010878g | ||
| 2286 | 3134 | 48 | None | -2 | 29 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 10.1021/jm400856t | ||
| 4927 | 3134 | 48 | None | -2 | 29 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 10.1021/jm400856t | ||
| 7282 | 3134 | 48 | None | -2 | 29 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 10.1021/jm400856t | ||
| CHEMBL643 | 3134 | 48 | None | -2 | 29 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 10.1021/jm400856t | ||
| DB01069 | 3134 | 48 | None | -2 | 29 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 10.1021/jm400856t | ||
| 1227 | 2454 | 35 | None | -5 | 11 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 2331 | 2454 | 35 | None | -5 | 11 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 3957 | 2454 | 35 | None | -5 | 11 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 4992 | 2454 | 35 | None | -5 | 11 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| CHEMBL511 | 2454 | 35 | None | -5 | 11 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| DB06691 | 2454 | 35 | None | -5 | 11 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm300671m | ||
| 44318842 | 204388 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1ccc2c(c1)N1OC(CN(C)C)CC1c1ccccc1C2 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL85735 | 204388 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1ccc2c(c1)N1OC(CN(C)C)CC1c1ccccc1C2 | 10.1016/s0960-894x(01)00721-1 | ||
| 4543 | 169982 | 36 | None | -1 | 29 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | nan | ||
| CHEMBL1201156 | 169982 | 36 | None | -1 | 29 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | nan | ||
| CHEMBL445 | 169982 | 36 | None | -1 | 29 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | nan | ||
| 11247939 | 136581 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 450 | 10 | 1 | 5 | 4.9 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(C)c21 | 10.1021/jm0498203 | ||
| CHEMBL374754 | 136581 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 450 | 10 | 1 | 5 | 4.9 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(C)c21 | 10.1021/jm0498203 | ||
| 11328514 | 137333 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 10 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(CCOc3cccc(F)c3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL376025 | 137333 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 10 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(CCOc3cccc(F)c3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 11373970 | 141441 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 436 | 9 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2cc(OC)ccc21 | 10.1021/jm0498203 | ||
| CHEMBL387325 | 141441 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 436 | 9 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(Cc3cccc(C(=O)O)c3)CC2)c2cc(OC)ccc21 | 10.1021/jm0498203 | ||
| 10263017 | 205729 | 2 | None | - | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 223 | 10 | 2 | 2 | 3.0 | NCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| CHEMBL94249 | 205729 | 2 | None | - | 3 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 223 | 10 | 2 | 2 | 3.0 | NCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm030936t | ||
| 44369359 | 46618 | 1 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 255 | 3 | 2 | 2 | 2.9 | NCCc1c[nH]c(-c2ccc(Cl)c(Cl)c2)n1 | 10.1021/jm030936t | ||
| CHEMBL154068 | 46618 | 1 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 255 | 3 | 2 | 2 | 2.9 | NCCc1c[nH]c(-c2ccc(Cl)c(Cl)c2)n1 | 10.1021/jm030936t | ||
| 657255 | 197406 | 29 | None | -18 | 15 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 337 | 12 | 2 | 3 | 5.6 | CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 | nan | ||
| CHEMBL588119 | 197406 | 29 | None | -18 | 15 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 337 | 12 | 2 | 3 | 5.6 | CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 | nan | ||
| 148123909 | 169666 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 505 | 6 | 1 | 6 | 5.1 | O=[N+]([O-])c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4445636 | 169666 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 505 | 6 | 1 | 6 | 5.1 | O=[N+]([O-])c1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 14762600 | 163899 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.3 | CCc1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL421393 | 163899 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.3 | CCc1ccccc1NC(=O)CCN1CCN2Cc3ccccc3CC2C1 | 10.1021/jm00173a011 | ||
| 45269063 | 194512 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 8 | 1 | 9 | 3.6 | CN(CCCN1CCC(CN2c3ccccc3Sc3ccc(C(=O)O)cc32)CC1)c1cc(=O)n(C)c(=O)n1C | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL561377 | 194512 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 8 | 1 | 9 | 3.6 | CN(CCCN1CCC(CN2c3ccccc3Sc3ccc(C(=O)O)cc32)CC1)c1cc(=O)n(C)c(=O)n1C | 10.1016/j.bmcl.2009.03.124 | ||
| 52953079 | 61672 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 519 | 6 | 1 | 9 | 2.4 | Cn1c(N2CCCN(CCCN3c4cc(C(=O)O)ccc4COc4ccccc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774496 | 61672 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 519 | 6 | 1 | 9 | 2.4 | Cn1c(N2CCCN(CCCN3c4cc(C(=O)O)ccc4COc4ccccc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 286016 | 4350 | 8 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 227 | 0 | 2 | 2 | 1.5 | c1ccc2c3c([nH]c2c1)CN1CCNCC1C3 | 10.1021/jm00173a011 | ||
| CHEMBL101491 | 4350 | 8 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 227 | 0 | 2 | 2 | 1.5 | c1ccc2c3c([nH]c2c1)CN1CCNCC1C3 | 10.1021/jm00173a011 | ||
| 54586254 | 61674 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 531 | 7 | 1 | 8 | 2.6 | Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774498 | 61674 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 531 | 7 | 1 | 8 | 2.6 | Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 54584335 | 61677 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 516 | 6 | 1 | 8 | 2.2 | Cn1c(N2CCN(CC/C=C3\c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774501 | 61677 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 516 | 6 | 1 | 8 | 2.2 | Cn1c(N2CCN(CC/C=C3\c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 17964355 | 125932 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL365197 | 125932 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccoc4)c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2004.12.008 | ||
| 14762591 | 4152 | 2 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 356 | 6 | 1 | 2 | 4.6 | O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| CHEMBL100276 | 4152 | 2 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 356 | 6 | 1 | 2 | 4.6 | O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| 10298838 | 168229 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.2 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CCc3ccccn3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL437519 | 168229 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 469 | 9 | 1 | 5 | 5.2 | O=C(O)c1ccccc1OCCN1CCC(c2cn(CCc3ccccn3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 22322323 | 194343 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 7 | 1 | 7 | 2.7 | Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL560120 | 194343 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 7 | 1 | 7 | 2.7 | Cn1c(NCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 10917690 | 205871 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1021/jm058225d | ||
| CHEMBL95051 | 205871 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1021/jm058225d | ||
| 44318461 | 204021 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1cccc2c1Cc1ccccc1C1CC(CN(C)C)ON21 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL82635 | 204021 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.7 | Cc1cccc2c1Cc1ccccc1C1CC(CN(C)C)ON21 | 10.1016/s0960-894x(01)00721-1 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 147863431 | 175366 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 4 | 5.2 | OC(COc1ccccc1)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4587694 | 175366 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 4 | 5.2 | OC(COc1ccccc1)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 9904205 | 204135 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
| CHEMBL83658 | 204135 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(02)00796-5 | ||
| 9904205 | 204135 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL83658 | 204135 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 9904205 | 204135 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL83658 | 204135 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 16005860 | 186823 | 6 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 | 10.1021/jm800830n | ||
| CHEMBL493677 | 186823 | 6 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 | 10.1021/jm800830n | ||
| 44461456 | 204035 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.8 | CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL82714 | 204035 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.8 | CN(C)CC1(C)CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 11508317 | 8056 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 336 | 5 | 0 | 3 | 5.1 | C[C@@H](c1ccccn1)c1c(CCN2CCCC2)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091774 | 8056 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 336 | 5 | 0 | 3 | 5.1 | C[C@@H](c1ccccn1)c1c(CCN2CCCC2)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 40466858 | 15979 | 62 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | 10.1007/s00044-008-9119-y | ||
| 5284514 | 15979 | 62 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | 10.1007/s00044-008-9119-y | ||
| CHEMBL1224 | 15979 | 62 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.0 | Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1 | 10.1007/s00044-008-9119-y | ||
| 136224310 | 84965 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 227 | 3 | 4 | 5 | -1.4 | CC(C)(CO)NC=C1C(=O)NC(=O)NC1=O | 10.1007/s00044-008-9119-y | ||
| CHEMBL2262481 | 84965 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 227 | 3 | 4 | 5 | -1.4 | CC(C)(CO)NC=C1C(=O)NC(=O)NC1=O | 10.1007/s00044-008-9119-y | ||
| 54586256 | 61680 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 516 | 5 | 1 | 8 | 2.7 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774504 | 61680 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 516 | 5 | 1 | 8 | 2.7 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 44271504 | 59405 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 495 | 9 | 1 | 5 | 5.2 | COC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm00121a022 | ||
| CHEMBL17237 | 59405 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 495 | 9 | 1 | 5 | 5.2 | COC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm00121a022 | ||
| 11230427 | 44469 | 1 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 249 | 9 | 1 | 2 | 3.4 | c1nc(CCCCCCCCN2CCCC2)c[nH]1 | 10.1021/jm030936t | ||
| CHEMBL152126 | 44469 | 1 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 249 | 9 | 1 | 2 | 3.4 | c1nc(CCCCCCCCN2CCCC2)c[nH]1 | 10.1021/jm030936t | ||
| 14762595 | 4378 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 402 | 5 | 2 | 3 | 3.8 | CCc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL101625 | 4378 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 402 | 5 | 2 | 3 | 3.8 | CCc1ccccc1NC(=O)CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1128/aac.00669-07 | ||
| 14762575 | 4120 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 4.1 | O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Br | 10.1021/jm00173a011 | ||
| CHEMBL100125 | 4120 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 4.1 | O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Br | 10.1021/jm00173a011 | ||
| 44461565 | 103871 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 4.2 | CN(C)CCCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL310018 | 103871 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 4.2 | CN(C)CCCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 4919 | 204511 | 21 | None | - | 9 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 287 | 5 | 1 | 2 | 3.9 | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 | 10.1021/jm300671m | ||
| CHEMBL86715 | 204511 | 21 | None | - | 9 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 287 | 5 | 1 | 2 | 3.9 | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 | 10.1021/jm300671m | ||
| 14762601 | 107875 | 1 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 369 | 4 | 1 | 3 | 3.4 | O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| CHEMBL319817 | 107875 | 1 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 369 | 4 | 1 | 3 | 3.4 | O=C(CCN1CCN2Cc3ccccc3CC2C1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| 45267329 | 194334 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 549 | 8 | 1 | 9 | 3.3 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL560061 | 194334 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 549 | 8 | 1 | 9 | 3.3 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(CCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 10478188 | 122427 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 436 | 9 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL360712 | 122427 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 436 | 9 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(Cc3ccc(OC)c(C(=O)O)c3)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 14762573 | 4415 | 2 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 2.2 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1 | 10.1021/jm00173a011 | ||
| CHEMBL101927 | 4415 | 2 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 2.2 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1 | 10.1021/jm00173a011 | ||
| 14762568 | 108735 | 2 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 357 | 6 | 1 | 3 | 2.9 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Cl | 10.1021/jm00173a011 | ||
| CHEMBL321738 | 108735 | 2 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 357 | 6 | 1 | 3 | 2.9 | O=C(NCCN1CCN(Cc2ccccc2)CC1)c1ccccc1Cl | 10.1021/jm00173a011 | ||
| 44318695 | 106522 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 370 | 3 | 0 | 3 | 5.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(-c4ccccc4)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL315308 | 106522 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 370 | 3 | 0 | 3 | 5.1 | CN(C)CC1CC2c3ccccc3Cc3ccc(-c4ccccc4)cc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 16722761 | 61673 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 517 | 6 | 1 | 8 | 2.6 | Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774497 | 61673 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 517 | 6 | 1 | 8 | 2.6 | Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 44392642 | 64921 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 478 | 8 | 1 | 5 | 5.9 | O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL182758 | 64921 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 478 | 8 | 1 | 5 | 5.9 | O=C(O)c1ccc(Cl)cc1OCCN1CCC(c2cn(Cc3ccoc3)c3ccccc23)CC1 | 10.1016/j.bmcl.2004.12.008 | ||
| 2253940 | 66918 | 11 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 237 | 2 | 3 | 4 | 0.2 | O=C1NC(=O)C(=CNC2CCCCC2)C(=O)N1 | 10.1007/s00044-008-9119-y | ||
| CHEMBL1880624 | 66918 | 11 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 237 | 2 | 3 | 4 | 0.2 | O=C1NC(=O)C(=CNC2CCCCC2)C(=O)N1 | 10.1007/s00044-008-9119-y | ||
| 14762572 | 111090 | 1 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 2.5 | Cc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| CHEMBL328170 | 111090 | 1 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 2.5 | Cc1ccccc1C(=O)NCCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| 100 | 3745 | 52 | None | -7 | 55 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| 2637 | 3745 | 52 | None | -7 | 55 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| 5452 | 3745 | 52 | None | -7 | 55 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| CHEMBL479 | 3745 | 52 | None | -7 | 55 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| DB00679 | 3745 | 52 | None | -7 | 55 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| 45270755 | 195061 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 1 | 9 | 3.5 | CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2 | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL565083 | 195061 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 1 | 9 | 3.5 | CC(C(=O)O)c1ccc2c(c1)N(CCCN1CCCN(c3cc(=O)n(C)c(=O)n3C)CC1)c1ccccc1S2 | 10.1016/j.bmcl.2009.03.124 | ||
| 135515198 | 104271 | 6 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1 | 10.1021/jm991005d | ||
| CHEMBL310712 | 104271 | 6 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1 | 10.1021/jm991005d | ||
| 135515198 | 104271 | 6 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1 | 10.1021/jm9704457 | ||
| CHEMBL310712 | 104271 | 6 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 2 | 1 | 7 | 3.3 | CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1 | 10.1021/jm9704457 | ||
| 1547484 | 927 | 70 | None | -1 | 20 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 654 | 927 | 70 | None | -1 | 20 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 9072 | 927 | 70 | None | -1 | 20 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL43064 | 927 | 70 | None | -1 | 20 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| DB00568 | 927 | 70 | None | -1 | 20 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 54586255 | 61675 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 559 | 7 | 1 | 8 | 3.3 | Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774499 | 61675 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 559 | 7 | 1 | 8 | 3.3 | Cn1c(N2CCCN(CCCN3c4ccccc4CCc4ccc(C(C)(C)C(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 11293983 | 83875 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 10 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| CHEMBL221413 | 83875 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 10 | 1 | 5 | 4.8 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | 10.1021/jm0498203 | ||
| 23027411 | 196843 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 387 | 5 | 2 | 5 | 3.7 | Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL577912 | 196843 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 387 | 5 | 2 | 5 | 3.7 | Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| 14762584 | 4291 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.4 | CCc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| CHEMBL101088 | 4291 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.4 | CCc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmc.2011.03.003 | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmc.2011.03.003 | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmc.2011.03.003 | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmc.2011.03.003 | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmc.2011.03.003 | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.03.124 | ||
| 10447834 | 1902 | 4 | None | -1862 | 6 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm030936t | ||
| 4026 | 1902 | 4 | None | -1862 | 6 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm030936t | ||
| CHEMBL275507 | 1902 | 4 | None | -1862 | 6 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 10.1021/jm030936t | ||
| 11816882 | 47240 | 1 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 220 | 9 | 1 | 2 | 3.3 | NCCCCCCCCCc1ccccn1 | 10.1021/jm030936t | ||
| CHEMBL154566 | 47240 | 1 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 220 | 9 | 1 | 2 | 3.3 | NCCCCCCCCCc1ccccn1 | 10.1021/jm030936t | ||
| 10885636 | 110527 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
| CHEMBL326263 | 110527 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
| 14762576 | 4399 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 356 | 6 | 1 | 2 | 4.0 | O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Cl | 10.1021/jm00173a011 | ||
| CHEMBL101758 | 4399 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 356 | 6 | 1 | 2 | 4.0 | O=C(NCCN1CCC(Cc2ccccc2)CC1)c1ccccc1Cl | 10.1021/jm00173a011 | ||
| 173727 | 59980 | 8 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm00121a022 | ||
| CHEMBL17436 | 59980 | 8 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm00121a022 | ||
| 155522480 | 170082 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1cccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4451332 | 170082 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.2 | COc1cccc(OCC(O)CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1 | 10.1016/j.bmcl.2019.126712 | ||
| 4011 | 81996 | 43 | None | 6 | 23 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | nan | ||
| CHEMBL21731 | 81996 | 43 | None | 6 | 23 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | nan | ||
| 1210 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 1213 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 2725 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 33036 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 4411 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 616 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 6976 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 716121 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 90475904 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| CHEMBL1201353 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| CHEMBL1554789 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| CHEMBL505 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| DB01114 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| DB13679 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00108a012 | ||
| 155549599 | 173281 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 474 | 5 | 1 | 4 | 5.5 | Cc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4539150 | 173281 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 474 | 5 | 1 | 4 | 5.5 | Cc1ccccc1OCC(O)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 2389 | 3279 | 114 | None | -331 | 67 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1073/pnas.0611417104 | ||
| 5073 | 3279 | 114 | None | -331 | 67 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1073/pnas.0611417104 | ||
| 96 | 3279 | 114 | None | -331 | 67 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1073/pnas.0611417104 | ||
| CHEMBL85 | 3279 | 114 | None | -331 | 67 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1073/pnas.0611417104 | ||
| DB00734 | 3279 | 114 | None | -331 | 67 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1073/pnas.0611417104 | ||
| 11329753 | 84140 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 514 | 10 | 1 | 5 | 5.4 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(Br)c21 | 10.1021/jm0498203 | ||
| CHEMBL222083 | 84140 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 514 | 10 | 1 | 5 | 5.4 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cccc(Br)c21 | 10.1021/jm0498203 | ||
| 45267775 | 194558 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 5 | 0 | 4 | 5.3 | CN(c1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL561690 | 194558 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 5 | 0 | 4 | 5.3 | CN(c1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 23027245 | 195452 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 387 | 5 | 2 | 5 | 3.7 | Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1 | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL567791 | 195452 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 387 | 5 | 2 | 5 | 3.7 | Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1 | 10.1016/j.bmcl.2009.09.003 | ||
| 10915140 | 29261 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.2 | COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1 | 10.1021/jm010992z | ||
| CHEMBL138458 | 29261 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.2 | COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1 | 10.1021/jm010992z | ||
| 76323071 | 84967 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 292 | 7 | 3 | 5 | 0.0 | CC(CO)(CO)NCCCN1C(=O)c2ccccc2C1=O | 10.1007/s00044-008-9119-y | ||
| CHEMBL2262485 | 84967 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 292 | 7 | 3 | 5 | 0.0 | CC(CO)(CO)NCCCN1C(=O)c2ccccc2C1=O | 10.1007/s00044-008-9119-y | ||
| 155545274 | 174381 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 5 | 1 | 4 | 6.2 | OC(COc1ccccc1C(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4565774 | 174381 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 5 | 1 | 4 | 6.2 | OC(COc1ccccc1C(F)(F)F)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 23027527 | 195117 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 371 | 5 | 2 | 5 | 3.1 | Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL565551 | 195117 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 371 | 5 | 2 | 5 | 3.1 | Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| 46182745 | 57029 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 6.2 | O=C(O)c1cc(-c2cccc(COc3ccc4c(c3)CN(C3CCCC3)C4=O)c2)ccc1Cl | 10.1021/jm3005306 | ||
| CHEMBL1651208 | 57029 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 6.2 | O=C(O)c1cc(-c2cccc(COc3ccc4c(c3)CN(C3CCCC3)C4=O)c2)ccc1Cl | 10.1021/jm3005306 | ||
| 11487026 | 84591 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 9 | 1 | 5 | 4.2 | COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL223889 | 84591 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 9 | 1 | 5 | 4.2 | COCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 44461606 | 105515 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 3.8 | CN(C)CCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| CHEMBL313189 | 105515 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 3.8 | CN(C)CCC1CC2c3ccccc3Cc3ccccc3N2O1 | 10.1016/s0960-894x(01)00721-1 | ||
| 14762592 | 4297 | 5 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 340 | 6 | 1 | 2 | 4.1 | O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1F | 10.1021/jm00173a011 | ||
| CHEMBL101133 | 4297 | 5 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 340 | 6 | 1 | 2 | 4.1 | O=C(CCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1F | 10.1021/jm00173a011 | ||
| 1342605 | 4331 | 15 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 357 | 6 | 1 | 3 | 3.5 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| CHEMBL101387 | 4331 | 15 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 357 | 6 | 1 | 3 | 3.5 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| 54587281 | 61676 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 516 | 6 | 1 | 8 | 2.2 | Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774500 | 61676 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 516 | 6 | 1 | 8 | 2.2 | Cn1c(N2CCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 2801 | 161325 | 56 | None | -1 | 28 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | nan | ||
| CHEMBL1200710 | 161325 | 56 | None | -1 | 28 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | nan | ||
| CHEMBL415 | 161325 | 56 | None | -1 | 28 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | nan | ||
| 11282005 | 65735 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL183706 | 65735 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 10 | 1 | 5 | 4.6 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 44392621 | 65992 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 10 | 0 | 5 | 4.7 | CCOCCn1cc(C2CCN(CCOc3ccccc3C=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| CHEMBL184989 | 65992 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 10 | 0 | 5 | 4.7 | CCOCCn1cc(C2CCN(CCOc3ccccc3C=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2004.12.008 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2016.04.087 | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2016.04.087 | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2016.04.087 | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2016.04.087 | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2016.04.087 | ||
| 21177786 | 84966 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 225 | 1 | 2 | 5 | -1.4 | O=C1NC(=O)C(=CN2CCOCC2)C(=O)N1 | 10.1007/s00044-008-9119-y | ||
| CHEMBL2262482 | 84966 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 225 | 1 | 2 | 5 | -1.4 | O=C1NC(=O)C(=CN2CCOCC2)C(=O)N1 | 10.1007/s00044-008-9119-y | ||
| 10273238 | 84330 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccco4)c4ccccc34)CC2)c1 | 10.1021/jm0498203 | ||
| CHEMBL222985 | 84330 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccco4)c4ccccc34)CC2)c1 | 10.1021/jm0498203 | ||
| 13726622 | 94142 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 311 | 3 | 0 | 4 | 2.2 | CN1C[C@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S | 10.1021/jm00108a012 | ||
| CHEMBL25198 | 94142 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 311 | 3 | 0 | 4 | 2.2 | CN1C[C@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S | 10.1021/jm00108a012 | ||
| 45273362 | 194799 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 551 | 8 | 1 | 10 | 2.8 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(OCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| CHEMBL563271 | 194799 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 551 | 8 | 1 | 10 | 2.8 | Cn1c(N2CCCN(CCCN3c4ccccc4Sc4ccc(OCC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmcl.2009.03.124 | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1073/pnas.0611417104 | ||
| 1385580 | 29063 | 73 | None | - | 5 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm00121a022 | ||
| 4615 | 29063 | 73 | None | - | 5 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm00121a022 | ||
| CHEMBL13828 | 29063 | 73 | None | - | 5 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm00121a022 | ||
| 150575506 | 171605 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.2 | COc1ccccc1OCCCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| CHEMBL4473466 | 171605 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.2 | COc1ccccc1OCCCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/j.bmcl.2019.126712 | ||
| 6761 | 67457 | 17 | None | -1 | 18 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | ||
| CHEMBL1909072 | 67457 | 17 | None | -1 | 18 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 10202996 | 84219 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 5.8 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)c1 | 10.1021/jm0498203 | ||
| CHEMBL222372 | 84219 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 5.8 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4cccs4)c4ccccc34)CC2)c1 | 10.1021/jm0498203 | ||
| 10162727 | 84195 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 6.0 | COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4cc(F)ccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| CHEMBL222139 | 84195 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 6.0 | COc1ccc(CN2CCC(c3cn(Cc4cccs4)c4cc(F)ccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| 54580386 | 61678 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 530 | 6 | 1 | 8 | 2.6 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| CHEMBL1774502 | 61678 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 530 | 6 | 1 | 8 | 2.6 | Cn1c(N2CCCN(CC/C=C3/c4ccccc4COc4ccc(CC(=O)O)cc43)CC2)cc(=O)n(C)c1=O | 10.1016/j.bmc.2011.03.003 | ||
| 45484995 | 196842 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 403 | 6 | 2 | 5 | 3.5 | Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| CHEMBL577904 | 196842 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 403 | 6 | 2 | 5 | 3.5 | Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C | 10.1016/j.bmcl.2009.09.003 | ||
| 44332030 | 111000 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 242 | 0 | 2 | 3 | 1.1 | NN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| CHEMBL327724 | 111000 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 242 | 0 | 2 | 3 | 1.1 | NN1CCN2Cc3[nH]c4ccccc4c3CC2C1 | 10.1021/jm00173a011 | ||
| 2600 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00020a018 | ||
| 2608 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00020a018 | ||
| 5405 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00020a018 | ||
| CHEMBL17157 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00020a018 | ||
| DB00342 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00020a018 | ||
| 14407102 | 13742 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | CCOC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm00121a022 | ||
| CHEMBL1195925 | 13742 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | CCOC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm00121a022 | ||
| CHEMBL555593 | 13742 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | CCOC(=O)c1ccc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm00121a022 | ||
| 10139591 | 84217 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 5.5 | COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4cc(F)ccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| CHEMBL222356 | 84217 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 462 | 7 | 1 | 5 | 5.5 | COc1ccc(CN2CCC(c3cn(Cc4ccoc4)c4cc(F)ccc34)CC2)cc1C(=O)O | 10.1021/jm0498203 | ||
| 14762594 | 110954 | 3 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 352 | 7 | 1 | 3 | 4.0 | COc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| CHEMBL327517 | 110954 | 3 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 352 | 7 | 1 | 3 | 4.0 | COc1ccccc1NC(=O)CCN1CCC(Cc2ccccc2)CC1 | 10.1021/jm00173a011 | ||
| 11338659 | 83886 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 8 | 1 | 4 | 4.8 | C=CCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| CHEMBL221463 | 83886 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 8 | 1 | 4 | 4.8 | C=CCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccccc21 | 10.1021/jm0498203 | ||
| 127049863 | 139722 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 4.5 | CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F | 10.1016/j.bmcl.2016.04.087 | ||
| CHEMBL3805518 | 139722 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 4.5 | CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F | 10.1016/j.bmcl.2016.04.087 | ||
| 14762596 | 4307 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 4 | 2 | 3 | 3.9 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| CHEMBL101217 | 4307 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 4 | 2 | 3 | 3.9 | O=C(CCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)Nc1ccccc1Cl | 10.1021/jm00173a011 | ||
| 10204866 | 84312 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 5.7 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3cccs3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL222881 | 84312 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 5.7 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3cccs3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 10138404 | 136359 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 5.2 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| CHEMBL374218 | 136359 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 5.2 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3ccco3)c3ccccc23)CC1 | 10.1021/jm0498203 | ||
| 100 | 3745 | 52 | None | -23 | 55 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 10.1021/jm00153a010 | ||
| 2637 | 3745 | 52 | None | -23 | 55 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 10.1021/jm00153a010 | ||
| 5452 | 3745 | 52 | None | -23 | 55 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 10.1021/jm00153a010 | ||
| CHEMBL479 | 3745 | 52 | None | -23 | 55 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 10.1021/jm00153a010 | ||
| DB00679 | 3745 | 52 | None | -23 | 55 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 10.1021/jm00153a010 | ||
| 191 | 399 | 92 | None | -56 | 28 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| 201 | 399 | 92 | None | -56 | 28 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| 2170 | 399 | 92 | None | -56 | 28 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| CHEMBL1113 | 399 | 92 | None | -56 | 28 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| DB00543 | 399 | 92 | None | -56 | 28 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm100064d | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm100064d | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm100064d | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm100064d | ||
| 1228 | 3805 | 31 | None | 5 | 4 | Guinea pig | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| 2763 | 3805 | 31 | None | 5 | 4 | Guinea pig | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| 5282443 | 3805 | 31 | None | 5 | 4 | Guinea pig | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| CHEMBL855 | 3805 | 31 | None | 5 | 4 | Guinea pig | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| DB00427 | 3805 | 31 | None | 5 | 4 | Guinea pig | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| 1227 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1007/s00044-012-0090-2 | ||
| 2331 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1007/s00044-012-0090-2 | ||
| 3957 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1007/s00044-012-0090-2 | ||
| 4992 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1007/s00044-012-0090-2 | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1007/s00044-012-0090-2 | ||
| DB06691 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1007/s00044-012-0090-2 | ||
| 1227 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1039/C8MD00527C | ||
| 2331 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1039/C8MD00527C | ||
| 3957 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1039/C8MD00527C | ||
| 4992 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1039/C8MD00527C | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1039/C8MD00527C | ||
| DB06691 | 2454 | 35 | None | 2 | 11 | Guinea pig | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1039/C8MD00527C | ||
| 277 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| 2913 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| 765 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| CHEMBL516 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| DB00434 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| 1227 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2015.02.037 | ||
| 2331 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2015.02.037 | ||
| 3957 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2015.02.037 | ||
| 4992 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2015.02.037 | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2015.02.037 | ||
| DB06691 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2015.02.037 | ||
| 11291 | 98340 | 21 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1021/jm00017a019 | ||
| CHEMBL278398 | 98340 | 21 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1021/jm00017a019 | ||
| 11097588 | 200452 | 1 | None | - | 1 | Guinea pig | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| CHEMBL609131 | 200452 | 1 | None | - | 1 | Guinea pig | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| 168279703 | 190544 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 1372 | 37 | 8 | 13 | 7.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5188259 | 190544 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 1372 | 37 | 8 | 13 | 7.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168279703 | 190544 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1372 | 37 | 8 | 13 | 7.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5188259 | 190544 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1372 | 37 | 8 | 13 | 7.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168282752 | 190502 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1303 | 32 | 8 | 13 | 7.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5187728 | 190502 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1303 | 32 | 8 | 13 | 7.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 11826604 | 39468 | 0 | None | -7585 | 3 | Guinea pig | 5.0 | pKd | = | 5 | Binding | ChEMBL | 457 | 10 | 1 | 4 | 6.4 | c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 | 10.1021/jm0110845 | ||
| CHEMBL14754 | 39468 | 0 | None | -7585 | 3 | Guinea pig | 5.0 | pKd | = | 5 | Binding | ChEMBL | 457 | 10 | 1 | 4 | 6.4 | c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 | 10.1021/jm0110845 | ||
| 11004759 | 42918 | 1 | None | -30902 | 3 | Guinea pig | 5.0 | pKd | = | 5 | Binding | ChEMBL | 443 | 9 | 1 | 4 | 6.0 | c1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 | 10.1021/jm0110845 | ||
| CHEMBL15056 | 42918 | 1 | None | -30902 | 3 | Guinea pig | 5.0 | pKd | = | 5 | Binding | ChEMBL | 443 | 9 | 1 | 4 | 6.0 | c1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 | 10.1021/jm0110845 | ||
| 44352460 | 20757 | 0 | None | -707 | 3 | Guinea pig | 5.0 | pKd | = | 5 | Binding | ChEMBL | 238 | 8 | 1 | 2 | 3.6 | CC(C)(C)CCCCOCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| CHEMBL131117 | 20757 | 0 | None | -707 | 3 | Guinea pig | 5.0 | pKd | = | 5 | Binding | ChEMBL | 238 | 8 | 1 | 2 | 3.6 | CC(C)(C)CCCCOCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| 155541141 | 176090 | 0 | None | -2 | 2 | Guinea pig | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 504 | 16 | 1 | 5 | 4.7 | N#C/N=C(\N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4517581 | 176090 | 0 | None | -2 | 2 | Guinea pig | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 504 | 16 | 1 | 5 | 4.7 | N#C/N=C(\N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4598140 | 176090 | 0 | None | -2 | 2 | Guinea pig | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 504 | 16 | 1 | 5 | 4.7 | N#C/N=C(\N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| 168282752 | 190502 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1303 | 32 | 8 | 13 | 7.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5187728 | 190502 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1303 | 32 | 8 | 13 | 7.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 90667434 | 109001 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 313 | 7 | 2 | 3 | 1.9 | CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1 | 10.1039/C3MD00245D | ||
| CHEMBL3220892 | 109001 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 313 | 7 | 2 | 3 | 1.9 | CC(CC(=O)/N=C(\N)NCCCn1ccnc1)c1ccccc1 | 10.1039/C3MD00245D | ||
| 168288124 | 191131 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1259 | 31 | 7 | 12 | 6.9 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5197183 | 191131 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1259 | 31 | 7 | 12 | 6.9 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168288124 | 191131 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1259 | 31 | 7 | 12 | 6.9 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5197183 | 191131 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1259 | 31 | 7 | 12 | 6.9 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 155540438 | 171974 | 0 | None | -7 | 2 | Guinea pig | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 290 | 3 | 1 | 6 | 1.3 | CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1 | 10.1016/j.bmc.2019.02.020 | ||
| CHEMBL4483783 | 171974 | 0 | None | -7 | 2 | Guinea pig | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 290 | 3 | 1 | 6 | 1.3 | CN1CCN(c2nc(N)nc(CC3CCCCC3)n2)CC1 | 10.1016/j.bmc.2019.02.020 | ||
| 155561756 | 175842 | 0 | None | -28 | 2 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 546 | 16 | 2 | 3 | 7.3 | N=C(N)N(CCCCC1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4585110 | 175842 | 0 | None | -28 | 2 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 546 | 16 | 2 | 3 | 7.3 | N=C(N)N(CCCCC1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4596105 | 175842 | 0 | None | -28 | 2 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 546 | 16 | 2 | 3 | 7.3 | N=C(N)N(CCCCC1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| 10902522 | 18787 | 0 | None | -1000 | 3 | Guinea pig | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 295 | 5 | 2 | 3 | 3.5 | CC(C)(C)C(NC(=O)OCCCc1c[nH]cn1)C(C)(C)C | 10.1021/jm020910m | ||
| CHEMBL128773 | 18787 | 0 | None | -1000 | 3 | Guinea pig | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 295 | 5 | 2 | 3 | 3.5 | CC(C)(C)C(NC(=O)OCCCc1c[nH]cn1)C(C)(C)C | 10.1021/jm020910m | ||
| 168284216 | 190283 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 1112 | 30 | 9 | 12 | 1.8 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5184842 | 190283 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 1112 | 30 | 9 | 12 | 1.8 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168284216 | 190283 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 1112 | 30 | 9 | 12 | 1.8 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5184842 | 190283 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 1112 | 30 | 9 | 12 | 1.8 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168269144 | 189405 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1193 | 28 | 6 | 14 | 6.0 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5171227 | 189405 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1193 | 28 | 6 | 14 | 6.0 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 25149335 | 183643 | 0 | None | - | 1 | Guinea pig | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1039/C3MD00245D | ||
| CHEMBL483406 | 183643 | 0 | None | - | 1 | Guinea pig | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1039/C3MD00245D | ||
| 168269144 | 189405 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1193 | 28 | 6 | 14 | 6.0 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5171227 | 189405 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1193 | 28 | 6 | 14 | 6.0 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168282405 | 190613 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 1101 | 28 | 7 | 10 | 4.5 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5189492 | 190613 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 1101 | 28 | 7 | 10 | 4.5 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168282405 | 190613 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 1101 | 28 | 7 | 10 | 4.5 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5189492 | 190613 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 1101 | 28 | 7 | 10 | 4.5 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 90667234 | 108985 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 314 | 7 | 3 | 3 | 1.4 | CC(CC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1039/C3MD00245D | ||
| CHEMBL3220635 | 108985 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 314 | 7 | 3 | 3 | 1.4 | CC(CC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1039/C3MD00245D | ||
| 168281594 | 190675 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1319 | 33 | 9 | 14 | 6.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5190566 | 190675 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1319 | 33 | 9 | 14 | 6.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 102596130 | 117196 | 15 | None | - | 1 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 405 | 0 | 0 | 5 | 4.0 | O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1cncn1 | 10.1016/j.bmcl.2015.02.037 | ||
| CHEMBL3401455 | 117196 | 15 | None | - | 1 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 405 | 0 | 0 | 5 | 4.0 | O=C(N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1)n1cncn1 | 10.1016/j.bmcl.2015.02.037 | ||
| 155554852 | 176038 | 0 | None | 10 | 2 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 339 | 11 | 2 | 2 | 4.4 | N=C(N)N(CCCCCCCOc1ccccc1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4550675 | 176038 | 0 | None | 10 | 2 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 339 | 11 | 2 | 2 | 4.4 | N=C(N)N(CCCCCCCOc1ccccc1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4597766 | 176038 | 0 | None | 10 | 2 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 339 | 11 | 2 | 2 | 4.4 | N=C(N)N(CCCCCCCOc1ccccc1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| 11437142 | 200919 | 1 | None | - | 1 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| CHEMBL612084 | 200919 | 1 | None | - | 1 | Guinea pig | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| 168281594 | 190675 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1319 | 33 | 9 | 14 | 6.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5190566 | 190675 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1319 | 33 | 9 | 14 | 6.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168297910 | 191855 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1223 | 29 | 7 | 15 | 5.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208512 | 191855 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1223 | 29 | 7 | 15 | 5.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168297910 | 191855 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1223 | 29 | 7 | 15 | 5.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208512 | 191855 | 0 | None | - | 1 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1223 | 29 | 7 | 15 | 5.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 90667235 | 108986 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 376 | 8 | 3 | 3 | 2.4 | N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1ncn[nH]1 | 10.1039/C3MD00245D | ||
| CHEMBL3220636 | 108986 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 376 | 8 | 3 | 3 | 2.4 | N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1ncn[nH]1 | 10.1039/C3MD00245D | ||
| 168280897 | 190192 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1383 | 39 | 10 | 15 | 4.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5183511 | 190192 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1383 | 39 | 10 | 15 | 4.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168280897 | 190192 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1383 | 39 | 10 | 15 | 4.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5183511 | 190192 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1383 | 39 | 10 | 15 | 4.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168285825 | 190951 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1278 | 31 | 8 | 16 | 4.7 | CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5194541 | 190951 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1278 | 31 | 8 | 16 | 4.7 | CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168285825 | 190951 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1278 | 31 | 8 | 16 | 4.7 | CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5194541 | 190951 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1278 | 31 | 8 | 16 | 4.7 | CC(C)[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168280529 | 190190 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1280 | 32 | 8 | 16 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5183487 | 190190 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1280 | 32 | 8 | 16 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168292310 | 191377 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1093 | 23 | 5 | 13 | 5.7 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5201153 | 191377 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1093 | 23 | 5 | 13 | 5.7 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 4161540 | 115589 | 24 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 412 | 2 | 1 | 4 | 4.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(CO)ccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL3357022 | 115589 | 24 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 412 | 2 | 1 | 4 | 4.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(CO)ccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 60150162 | 173294 | 0 | None | -32 | 5 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 479 | 16 | 2 | 4 | 4.8 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4539444 | 173294 | 0 | None | -32 | 5 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 479 | 16 | 2 | 4 | 4.8 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccccc1 | 10.1039/C8MD00527C | ||
| 10933521 | 162913 | 0 | None | -100 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 237 | 6 | 2 | 3 | 1.9 | CC(NC(=O)OCCCc1c[nH]cn1)C1CC1 | 10.1021/jm020910m | ||
| CHEMBL419975 | 162913 | 0 | None | -100 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 237 | 6 | 2 | 3 | 1.9 | CC(NC(=O)OCCCc1c[nH]cn1)C1CC1 | 10.1021/jm020910m | ||
| 10977121 | 20584 | 2 | None | -3715 | 3 | Guinea pig | 4.7 | pKd | = | 4.7 | Binding | ChEMBL | 224 | 7 | 1 | 2 | 3.2 | CC(C)(C)CCCOCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| CHEMBL130958 | 20584 | 2 | None | -3715 | 3 | Guinea pig | 4.7 | pKd | = | 4.7 | Binding | ChEMBL | 224 | 7 | 1 | 2 | 3.2 | CC(C)(C)CCCOCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| 168280529 | 190190 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1280 | 32 | 8 | 16 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5183487 | 190190 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1280 | 32 | 8 | 16 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168292310 | 191377 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1093 | 23 | 5 | 13 | 5.7 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5201153 | 191377 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1093 | 23 | 5 | 13 | 5.7 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 12884174 | 177164 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 348 | 1 | 0 | 3 | 4.2 | CCOC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4642460 | 177164 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 348 | 1 | 0 | 3 | 4.2 | CCOC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 168269973 | 189334 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1166 | 31 | 9 | 13 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5169978 | 189334 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1166 | 31 | 9 | 13 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168269973 | 189334 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1166 | 31 | 9 | 13 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5169978 | 189334 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1166 | 31 | 9 | 13 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 6604035 | 167512 | 5 | None | - | 1 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | CC(C)(C)c1ccc([C@@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/S0960-894X(00)80261-9 | ||
| CHEMBL432527 | 167512 | 5 | None | - | 1 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | CC(C)(C)c1ccc([C@@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/S0960-894X(00)80261-9 | ||
| 168280244 | 190377 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1462 | 38 | 10 | 17 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5186049 | 190377 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1462 | 38 | 10 | 17 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168284928 | 190790 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1451 | 36 | 8 | 15 | 7.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192377 | 190790 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1451 | 36 | 8 | 15 | 7.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168280244 | 190377 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1462 | 38 | 10 | 17 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5186049 | 190377 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1462 | 38 | 10 | 17 | 4.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168284928 | 190790 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1451 | 36 | 8 | 15 | 7.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192377 | 190790 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1451 | 36 | 8 | 15 | 7.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCCCC[N+]1=C(/C=C/C=C/C=C2/N(C)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 60150166 | 174152 | 0 | None | -60 | 5 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 524 | 17 | 2 | 6 | 4.7 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4560123 | 174152 | 0 | None | -60 | 5 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 524 | 17 | 2 | 6 | 4.7 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc([N+](=O)[O-])cc1 | 10.1039/C8MD00527C | ||
| 156012610 | 176820 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 400 | 1 | 0 | 3 | 5.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(F)c3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4638183 | 176820 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 400 | 1 | 0 | 3 | 5.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(F)c3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 90667227 | 108980 | 0 | None | - | 1 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 375 | 8 | 2 | 3 | 2.9 | N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCn1ccnc1 | 10.1039/C3MD00245D | ||
| CHEMBL3220628 | 108980 | 0 | None | - | 1 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 375 | 8 | 2 | 3 | 2.9 | N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCn1ccnc1 | 10.1039/C3MD00245D | ||
| 155540201 | 172339 | 0 | None | -15 | 5 | Guinea pig | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 513 | 16 | 2 | 4 | 5.5 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4516173 | 172339 | 0 | None | -15 | 5 | Guinea pig | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 513 | 16 | 2 | 4 | 5.5 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(Cl)cc1 | 10.1039/C8MD00527C | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.0c00483 | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.0c00483 | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.0c00483 | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.0c00483 | ||
| 10916261 | 35066 | 0 | None | -30902 | 3 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 395 | 7 | 1 | 4 | 5.9 | Clc1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| CHEMBL14364 | 35066 | 0 | None | -30902 | 3 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 395 | 7 | 1 | 4 | 5.9 | Clc1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| 9794557 | 19799 | 0 | None | -83 | 3 | Guinea pig | 4.6 | pKd | = | 4.6 | Binding | ChEMBL | 227 | 6 | 0 | 2 | 3.3 | CC(C)(C)CCOCCCN1CCCCC1 | 10.1021/jm020910m | ||
| CHEMBL130331 | 19799 | 0 | None | -83 | 3 | Guinea pig | 4.6 | pKd | = | 4.6 | Binding | ChEMBL | 227 | 6 | 0 | 2 | 3.3 | CC(C)(C)CCOCCCN1CCCCC1 | 10.1021/jm020910m | ||
| 156013234 | 176929 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 398 | 1 | 1 | 4 | 4.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3C(O)Cc3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4639563 | 176929 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 398 | 1 | 1 | 4 | 4.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3C(O)Cc3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 90667233 | 108984 | 0 | None | - | 1 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 375 | 8 | 3 | 2 | 3.0 | N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1cn[nH]c1 | 10.1039/C3MD00245D | ||
| CHEMBL3220634 | 108984 | 0 | None | - | 1 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 375 | 8 | 3 | 2 | 3.0 | N/C(=N\C(=O)CC(c1ccccc1)c1ccccc1)NCCCc1cn[nH]c1 | 10.1039/C3MD00245D | ||
| 168281433 | 190365 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1214 | 34 | 8 | 11 | 5.2 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185960 | 190365 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1214 | 34 | 8 | 11 | 5.2 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168281433 | 190365 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1214 | 34 | 8 | 11 | 5.2 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185960 | 190365 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1214 | 34 | 8 | 11 | 5.2 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 156010880 | 176569 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 432 | 2 | 0 | 3 | 5.8 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C(F)F)ccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4633975 | 176569 | 0 | None | - | 1 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 432 | 2 | 0 | 3 | 5.8 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C(F)F)ccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 168290008 | 191221 | 0 | None | - | 1 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1180 | 27 | 7 | 15 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5198557 | 191221 | 0 | None | - | 1 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1180 | 27 | 7 | 15 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 14637775 | 177464 | 23 | None | - | 1 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 326 | 0 | 2 | 3 | 3.5 | OC1Cc2cc(Cl)ccc2C(=C2CCNCC2)c2ncccc21 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4647038 | 177464 | 23 | None | - | 1 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 326 | 0 | 2 | 3 | 3.5 | OC1Cc2cc(Cl)ccc2C(=C2CCNCC2)c2ncccc21 | 10.1021/acs.jmedchem.0c00483 | ||
| 168290008 | 191221 | 0 | None | - | 1 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1180 | 27 | 7 | 15 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5198557 | 191221 | 0 | None | - | 1 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1180 | 27 | 7 | 15 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 155550732 | 176055 | 0 | None | -11 | 3 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 323 | 8 | 0 | 2 | 5.4 | c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL4540849 | 176055 | 0 | None | -11 | 3 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 323 | 8 | 0 | 2 | 5.4 | c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL4597895 | 176055 | 0 | None | -11 | 3 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 323 | 8 | 0 | 2 | 5.4 | c1ccc(-c2ccc(OCCCCCN3CCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm100064d | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm100064d | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm100064d | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm100064d | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm100064d | ||
| 168280938 | 190236 | 0 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 1270 | 33 | 9 | 14 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5184108 | 190236 | 0 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 1270 | 33 | 9 | 14 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 90667430 | 109000 | 0 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 370 | 9 | 2 | 3 | 2.9 | CC(CC(=O)/N=C(\N)NCCCc1ccc(CN(C)C)o1)c1ccccc1 | 10.1039/C3MD00245D | ||
| CHEMBL3220888 | 109000 | 0 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 370 | 9 | 2 | 3 | 2.9 | CC(CC(=O)/N=C(\N)NCCCc1ccc(CN(C)C)o1)c1ccccc1 | 10.1039/C3MD00245D | ||
| 2600 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(00)80261-9 | ||
| 2608 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(00)80261-9 | ||
| 5405 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(00)80261-9 | ||
| CHEMBL17157 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(00)80261-9 | ||
| DB00342 | 3720 | 73 | None | -3 | 13 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/S0960-894X(00)80261-9 | ||
| 118729369 | 117343 | 0 | None | - | 1 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 368 | 0 | 0 | 4 | 4.3 | O=C(N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1)n1cncn1 | 10.1016/j.bmcl.2015.02.037 | ||
| CHEMBL3402827 | 117343 | 0 | None | - | 1 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 368 | 0 | 0 | 4 | 4.3 | O=C(N1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1)n1cncn1 | 10.1016/j.bmcl.2015.02.037 | ||
| 11080253 | 36352 | 0 | None | -2041 | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 417 | 11 | 1 | 4 | 5.9 | c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| CHEMBL14484 | 36352 | 0 | None | -2041 | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 417 | 11 | 1 | 4 | 5.9 | c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| 11748564 | 18744 | 0 | None | -1584 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 299 | 7 | 2 | 3 | 3.2 | O=C(NC(c1ccccc1)C1CC1)OCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| CHEMBL128585 | 18744 | 0 | None | -1584 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 299 | 7 | 2 | 3 | 3.2 | O=C(NC(c1ccccc1)C1CC1)OCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| 60150164 | 175186 | 0 | None | -107 | 2 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 547 | 16 | 2 | 4 | 5.8 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4583515 | 175186 | 0 | None | -107 | 2 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 547 | 16 | 2 | 4 | 5.8 | N=C(N)N(CCCCN1CCN(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| 11725577 | 11079 | 0 | None | -26 | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 352 | 7 | 0 | 4 | 4.6 | CO/N=C(\C)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL1178642 | 11079 | 0 | None | -26 | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 352 | 7 | 0 | 4 | 4.6 | CO/N=C(\C)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL35869 | 11079 | 0 | None | -26 | 3 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 352 | 7 | 0 | 4 | 4.6 | CO/N=C(\C)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| 2600 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00013a023 | ||
| 2608 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00013a023 | ||
| 5405 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00013a023 | ||
| CHEMBL17157 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00013a023 | ||
| DB00342 | 3720 | 73 | None | -3 | 13 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm00013a023 | ||
| 7048803 | 101833 | 3 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | CC(C)(C)c1ccc([C@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/S0960-894X(00)80261-9 | ||
| CHEMBL303454 | 101833 | 3 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | CC(C)(C)c1ccc([C@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/S0960-894X(00)80261-9 | ||
| 90667232 | 108983 | 0 | None | - | 1 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1cn[nH]c1)c1ccccc1 | 10.1039/C3MD00245D | ||
| CHEMBL3220633 | 108983 | 0 | None | - | 1 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 313 | 7 | 3 | 2 | 2.0 | CC(CC(=O)/N=C(\N)NCCCc1cn[nH]c1)c1ccccc1 | 10.1039/C3MD00245D | ||
| 10949464 | 97737 | 0 | None | -5128 | 3 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 403 | 10 | 1 | 4 | 5.5 | c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| CHEMBL274041 | 97737 | 0 | None | -5128 | 3 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 403 | 10 | 1 | 4 | 5.5 | c1ccc2c(NCCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| 44352410 | 19385 | 0 | None | -10 | 2 | Guinea pig | 4.4 | pKd | = | 4.4 | Binding | ChEMBL | 270 | 5 | 1 | 3 | 3.0 | CC(NC(=O)OCCCN1CCCCC1)C(C)(C)C | 10.1021/jm020910m | ||
| CHEMBL130005 | 19385 | 0 | None | -10 | 2 | Guinea pig | 4.4 | pKd | = | 4.4 | Binding | ChEMBL | 270 | 5 | 1 | 3 | 3.0 | CC(NC(=O)OCCCN1CCCCC1)C(C)(C)C | 10.1021/jm020910m | ||
| 168280938 | 190236 | 0 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 1270 | 33 | 9 | 14 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5184108 | 190236 | 0 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 1270 | 33 | 9 | 14 | 4.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 119570 | 3110 | 90 | None | -162 | 40 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/acs.jmedchem.1c00692 | ||
| 2233 | 3110 | 90 | None | -162 | 40 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/acs.jmedchem.1c00692 | ||
| 953 | 3110 | 90 | None | -162 | 40 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL301265 | 3110 | 90 | None | -162 | 40 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/acs.jmedchem.1c00692 | ||
| DB00413 | 3110 | 90 | None | -162 | 40 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | 10.1021/acs.jmedchem.1c00692 | ||
| 168268716 | 192160 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 372 | 3 | 4 | 4 | 3.5 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5170276 | 192160 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 372 | 3 | 4 | 4 | 3.5 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221176 | 192160 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 372 | 3 | 4 | 4 | 3.5 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168268680 | 192164 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5172675 | 192164 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221210 | 192164 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168268827 | 192177 | 0 | None | -4 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5179906 | 192177 | 0 | None | -4 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221314 | 192177 | 0 | None | -4 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168268853 | 192183 | 0 | None | -19 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 389 | 8 | 4 | 5 | 1.9 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5180504 | 192183 | 0 | None | -19 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 389 | 8 | 4 | 5 | 1.9 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221353 | 192183 | 0 | None | -19 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 389 | 8 | 4 | 5 | 1.9 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168273471 | 192199 | 0 | None | -12 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 596 | 17 | 8 | 10 | 0.7 | N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5173079 | 192199 | 0 | None | -12 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 596 | 17 | 8 | 10 | 0.7 | N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221433 | 192199 | 0 | None | -12 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 596 | 17 | 8 | 10 | 0.7 | N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168273549 | 192201 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5174342 | 192201 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221438 | 192201 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168273640 | 192203 | 0 | None | -100 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 568 | 15 | 8 | 10 | -0.1 | N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5176229 | 192203 | 0 | None | -100 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 568 | 15 | 8 | 10 | -0.1 | N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221444 | 192203 | 0 | None | -100 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 568 | 15 | 8 | 10 | -0.1 | N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168273745 | 192206 | 0 | None | -114 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 332 | 6 | 4 | 4 | 1.5 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5178472 | 192206 | 0 | None | -114 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 332 | 6 | 4 | 4 | 1.5 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221451 | 192206 | 0 | None | -114 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 332 | 6 | 4 | 4 | 1.5 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168274129 | 192207 | 0 | None | -16 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 370 | 12 | 5 | 6 | 1.0 | NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5176780 | 192207 | 0 | None | -16 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 370 | 12 | 5 | 6 | 1.0 | NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221468 | 192207 | 0 | None | -16 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 370 | 12 | 5 | 6 | 1.0 | NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168275750 | 192224 | 0 | None | -72 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 332 | 6 | 3 | 4 | 1.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5175558 | 192224 | 0 | None | -72 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 332 | 6 | 3 | 4 | 1.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221581 | 192224 | 0 | None | -72 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 332 | 6 | 3 | 4 | 1.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168276867 | 192233 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5174278 | 192233 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221653 | 192233 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168277996 | 192244 | 0 | None | -60 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5173373 | 192244 | 0 | None | -60 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221736 | 192244 | 0 | None | -60 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168278471 | 192246 | 0 | None | -229 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 312 | 8 | 4 | 4 | 1.5 | CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5183205 | 192246 | 0 | None | -229 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 312 | 8 | 4 | 4 | 1.5 | CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221757 | 192246 | 0 | None | -229 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 312 | 8 | 4 | 4 | 1.5 | CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168278543 | 192249 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 358 | 4 | 4 | 4 | 1.6 | N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5184846 | 192249 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 358 | 4 | 4 | 4 | 1.6 | N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221764 | 192249 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 358 | 4 | 4 | 4 | 1.6 | N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168280339 | 192263 | 0 | None | 3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 372 | 8 | 3 | 5 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5188592 | 192263 | 0 | None | 3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 372 | 8 | 3 | 5 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221885 | 192263 | 0 | None | 3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 372 | 8 | 3 | 5 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCn1cc(CN(C)C)nn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168281536 | 192279 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 369 | 12 | 4 | 5 | 1.7 | Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5189006 | 192279 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 369 | 12 | 4 | 5 | 1.7 | Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221966 | 192279 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 369 | 12 | 4 | 5 | 1.7 | Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168281746 | 192280 | 0 | None | -14454 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 365 | 6 | 4 | 5 | 1.6 | CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5184911 | 192280 | 0 | None | -14454 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 365 | 6 | 4 | 5 | 1.6 | CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221974 | 192280 | 0 | None | -14454 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 365 | 6 | 4 | 5 | 1.6 | CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168283097 | 192291 | 0 | None | -66 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 311 | 9 | 4 | 5 | 0.8 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5186770 | 192291 | 0 | None | -66 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 311 | 9 | 4 | 5 | 0.8 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222043 | 192291 | 0 | None | -66 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 311 | 9 | 4 | 5 | 0.8 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168283321 | 192293 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 364 | 7 | 4 | 4 | 2.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5183015 | 192293 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 364 | 7 | 4 | 4 | 2.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222057 | 192293 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 364 | 7 | 4 | 4 | 2.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168283536 | 192298 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 312 | 8 | 3 | 4 | 1.6 | CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5187758 | 192298 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 312 | 8 | 3 | 4 | 1.6 | CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222074 | 192298 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 312 | 8 | 3 | 4 | 1.6 | CCCCCNC(=O)/N=C(/N)NCCCc1nnc(C)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168284289 | 192304 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 428 | 8 | 4 | 4 | 3.1 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5194860 | 192304 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 428 | 8 | 4 | 4 | 3.1 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222123 | 192304 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 428 | 8 | 4 | 4 | 3.1 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168284480 | 192308 | 0 | None | -66 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 330 | 6 | 4 | 4 | 1.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5197548 | 192308 | 0 | None | -66 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 330 | 6 | 4 | 4 | 1.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222137 | 192308 | 0 | None | -66 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 330 | 6 | 4 | 4 | 1.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168286141 | 192322 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5192993 | 192322 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222231 | 192322 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168286426 | 192324 | 0 | None | -58 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 403 | 10 | 4 | 5 | 2.3 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5198795 | 192324 | 0 | None | -58 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 403 | 10 | 4 | 5 | 2.3 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222241 | 192324 | 0 | None | -58 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 403 | 10 | 4 | 5 | 2.3 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168290235 | 192366 | 0 | None | -12882 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5201074 | 192366 | 0 | None | -12882 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222491 | 192366 | 0 | None | -12882 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168290815 | 192371 | 0 | None | -10232 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 327 | 9 | 4 | 5 | 1.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5200771 | 192371 | 0 | None | -10232 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 327 | 9 | 4 | 5 | 1.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222529 | 192371 | 0 | None | -10232 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 327 | 9 | 4 | 5 | 1.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168291233 | 192377 | 0 | None | -6 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 373 | 8 | 4 | 5 | 1.4 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5200106 | 192377 | 0 | None | -6 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 373 | 8 | 4 | 5 | 1.4 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222556 | 192377 | 0 | None | -6 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 373 | 8 | 4 | 5 | 1.4 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168292954 | 192395 | 0 | None | -44 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.5 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5202592 | 192395 | 0 | None | -44 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.5 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222660 | 192395 | 0 | None | -44 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.5 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294161 | 192404 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5204739 | 192404 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222742 | 192404 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294445 | 192408 | 0 | None | 1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.6 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208113 | 192408 | 0 | None | 1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.6 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222768 | 192408 | 0 | None | 1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.6 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294166 | 192412 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5209081 | 192412 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222775 | 192412 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294449 | 192416 | 0 | None | -74 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 367 | 7 | 4 | 5 | 1.9 | CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5204599 | 192416 | 0 | None | -74 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 367 | 7 | 4 | 5 | 1.9 | CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222793 | 192416 | 0 | None | -74 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 367 | 7 | 4 | 5 | 1.9 | CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294767 | 192417 | 0 | None | -3235 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5207281 | 192417 | 0 | None | -3235 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222802 | 192417 | 0 | None | -3235 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294770 | 192418 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208327 | 192418 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222806 | 192418 | 0 | None | -2 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294776 | 192424 | 0 | None | -11 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 366 | 7 | 3 | 4 | 2.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5209479 | 192424 | 0 | None | -11 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 366 | 7 | 3 | 4 | 2.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222831 | 192424 | 0 | None | -11 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 366 | 7 | 3 | 4 | 2.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168295528 | 192429 | 0 | None | -2951 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5206565 | 192429 | 0 | None | -2951 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222872 | 192429 | 0 | None | -2951 | 20 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294178 | 192433 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 414 | 5 | 4 | 4 | 4.4 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5205197 | 192433 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 414 | 5 | 4 | 4 | 4.4 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222887 | 192433 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 414 | 5 | 4 | 4 | 4.4 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168295541 | 192438 | 0 | None | -301 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 347 | 6 | 4 | 5 | 1.4 | C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208845 | 192438 | 0 | None | -301 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 347 | 6 | 4 | 5 | 1.4 | C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222926 | 192438 | 0 | None | -301 | 6 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 347 | 6 | 4 | 5 | 1.4 | C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168295543 | 192439 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5209021 | 192439 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222929 | 192439 | 0 | None | -1 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168295803 | 192443 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.6 | CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5207206 | 192443 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.6 | CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222937 | 192443 | 0 | None | -3 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.6 | CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294182 | 192446 | 0 | None | -57 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 314 | 6 | 4 | 2 | 1.7 | C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208722 | 192446 | 0 | None | -57 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 314 | 6 | 4 | 2 | 1.7 | C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222960 | 192446 | 0 | None | -57 | 4 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 314 | 6 | 4 | 2 | 1.7 | C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168286984 | 190798 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1254 | 32 | 8 | 13 | 5.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192474 | 190798 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1254 | 32 | 8 | 13 | 5.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168289844 | 190739 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5191552 | 190739 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 10744393 | 71120 | 0 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | ||
| CHEMBL196220 | 71120 | 0 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | ||
| 156021916 | 177616 | 0 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 398 | 1 | 1 | 4 | 3.9 | CCOC(=O)N1CC/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)C(O)C1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4649344 | 177616 | 0 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 398 | 1 | 1 | 4 | 3.9 | CCOC(=O)N1CC/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)C(O)C1 | 10.1021/acs.jmedchem.0c00483 | ||
| 168269233 | 189323 | 0 | None | - | 1 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1205 | 30 | 7 | 11 | 5.8 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5169872 | 189323 | 0 | None | - | 1 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1205 | 30 | 7 | 11 | 5.8 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168269233 | 189323 | 0 | None | - | 1 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1205 | 30 | 7 | 11 | 5.8 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5169872 | 189323 | 0 | None | - | 1 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1205 | 30 | 7 | 11 | 5.8 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 156016191 | 177126 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 380 | 1 | 0 | 3 | 5.0 | CCOC(=O)N1C=C/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4642056 | 177126 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 380 | 1 | 0 | 3 | 5.0 | CCOC(=O)N1C=C/C(=C2/c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 156019460 | 177369 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 398 | 1 | 1 | 4 | 4.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(O)c3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4645629 | 177369 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 398 | 1 | 1 | 4 | 4.4 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CC(O)c3cccnc32)CC1 | 10.1021/acs.jmedchem.0c00483 | ||
| 10936212 | 11107 | 1 | None | -74 | 3 | Guinea pig | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 323 | 6 | 0 | 3 | 4.5 | CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL1178750 | 11107 | 1 | None | -74 | 3 | Guinea pig | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 323 | 6 | 0 | 3 | 4.5 | CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL39603 | 11107 | 1 | None | -74 | 3 | Guinea pig | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 323 | 6 | 0 | 3 | 4.5 | CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| 14637770 | 177523 | 23 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 326 | 0 | 2 | 3 | 3.5 | OC1Cc2cccnc2C(=C2CCNCC2)c2ccc(Cl)cc21 | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4647890 | 177523 | 23 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 326 | 0 | 2 | 3 | 3.5 | OC1Cc2cccnc2C(=C2CCNCC2)c2ccc(Cl)cc21 | 10.1021/acs.jmedchem.0c00483 | ||
| 168272779 | 189970 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1191 | 27 | 6 | 14 | 6.2 | C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5180096 | 189970 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1191 | 27 | 6 | 14 | 6.2 | C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168283831 | 190336 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1256 | 32 | 9 | 14 | 3.9 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185508 | 190336 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1256 | 32 | 9 | 14 | 3.9 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168289844 | 190739 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5191552 | 190739 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC[C@H](C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168286984 | 190798 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1254 | 32 | 8 | 13 | 5.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192474 | 190798 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1254 | 32 | 8 | 13 | 5.2 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168283831 | 190336 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1256 | 32 | 9 | 14 | 3.9 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185508 | 190336 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1256 | 32 | 9 | 14 | 3.9 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168272779 | 189970 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1191 | 27 | 6 | 14 | 6.2 | C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5180096 | 189970 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1191 | 27 | 6 | 14 | 6.2 | C[C@H](NC(=O)CCN(C)CC/C=C1\c2ccccc2COc2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCC(=O)N[C@@H](CCCn1cc(COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)nn1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168289771 | 191217 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5198492 | 191217 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168297510 | 191881 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1305 | 32 | 9 | 14 | 6.0 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208869 | 191881 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1305 | 32 | 9 | 14 | 6.0 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44461723 | 204239 | 0 | None | 398 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | ||
| CHEMBL84407 | 204239 | 0 | None | 398 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | ||
| 10435880 | 203649 | 0 | None | 707 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | ||
| CHEMBL79732 | 203649 | 0 | None | 707 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | ||
| 10067161 | 43869 | 1 | None | -30199 | 3 | Guinea pig | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 361 | 7 | 1 | 4 | 5.2 | c1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| CHEMBL15153 | 43869 | 1 | None | -30199 | 3 | Guinea pig | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 361 | 7 | 1 | 4 | 5.2 | c1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| 11107010 | 18776 | 2 | None | -1000 | 3 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 224 | 6 | 1 | 2 | 3.2 | CC(CC(C)(C)C)OCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| CHEMBL128714 | 18776 | 2 | None | -1000 | 3 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 224 | 6 | 1 | 2 | 3.2 | CC(CC(C)(C)C)OCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| 10956869 | 62723 | 0 | None | -5128 | 3 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 279 | 6 | 2 | 3 | 3.0 | C[C@@H](NC(=O)OCCCc1c[nH]cn1)C1CCCCC1 | 10.1021/jm020910m | ||
| CHEMBL1788247 | 62723 | 0 | None | -5128 | 3 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 279 | 6 | 2 | 3 | 3.0 | C[C@@H](NC(=O)OCCCc1c[nH]cn1)C1CCCCC1 | 10.1021/jm020910m | ||
| 156012578 | 176785 | 0 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 414 | 1 | 2 | 5 | 3.5 | CCOC(=O)N1C(O)CC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1O | 10.1021/acs.jmedchem.0c00483 | ||
| CHEMBL4637657 | 176785 | 0 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 414 | 1 | 2 | 5 | 3.5 | CCOC(=O)N1C(O)CC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1O | 10.1021/acs.jmedchem.0c00483 | ||
| 168297282 | 191879 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 1225 | 36 | 10 | 13 | 2.4 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208850 | 191879 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 1225 | 36 | 10 | 13 | 2.4 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168297282 | 191879 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 1225 | 36 | 10 | 13 | 2.4 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208850 | 191879 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 1225 | 36 | 10 | 13 | 2.4 | Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN3CCC(Oc4ccccc4Cc4ccccc4)CC3)C(C)C)C(N)=O)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 277 | 1274 | 55 | None | -2 | 45 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm058225d | ||
| 2913 | 1274 | 55 | None | -2 | 45 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm058225d | ||
| 765 | 1274 | 55 | None | -2 | 45 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm058225d | ||
| CHEMBL516 | 1274 | 55 | None | -2 | 45 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm058225d | ||
| DB00434 | 1274 | 55 | None | -2 | 45 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm058225d | ||
| 168289021 | 191181 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1272 | 33 | 10 | 15 | 2.9 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5197990 | 191181 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1272 | 33 | 10 | 15 | 2.9 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168289771 | 191217 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5198492 | 191217 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1284 | 34 | 9 | 14 | 4.6 | CC(C)C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168297510 | 191881 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1305 | 32 | 9 | 14 | 6.0 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208869 | 191881 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1305 | 32 | 9 | 14 | 6.0 | C[C@H](NC(=O)[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168289021 | 191181 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1272 | 33 | 10 | 15 | 2.9 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5197990 | 191181 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1272 | 33 | 10 | 15 | 2.9 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168295200 | 191791 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1321 | 33 | 10 | 15 | 5.0 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5207609 | 191791 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1321 | 33 | 10 | 15 | 5.0 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 155539314 | 175806 | 0 | None | -5 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 628 | 14 | 4 | 4 | 5.0 | N=C(N)N(CCCCN1CCN(CCCCN(Cc2ccc(C(F)(F)F)cc2)C(=N)N)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4514561 | 175806 | 0 | None | -5 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 628 | 14 | 4 | 4 | 5.0 | N=C(N)N(CCCCN1CCN(CCCCN(Cc2ccc(C(F)(F)F)cc2)C(=N)N)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4595855 | 175806 | 0 | None | -5 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 628 | 14 | 4 | 4 | 5.0 | N=C(N)N(CCCCN1CCN(CCCCN(Cc2ccc(C(F)(F)F)cc2)C(=N)N)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| 155553524 | 175945 | 0 | None | -5 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 546 | 16 | 2 | 3 | 7.3 | N=C(N)N(CCCCN1CCC(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4546027 | 175945 | 0 | None | -5 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 546 | 16 | 2 | 3 | 7.3 | N=C(N)N(CCCCN1CCC(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4596938 | 175945 | 0 | None | -5 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 546 | 16 | 2 | 3 | 7.3 | N=C(N)N(CCCCN1CCC(CCCCCCCOc2ccccc2)CC1)Cc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| 168283519 | 190470 | 0 | None | - | 1 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1216 | 32 | 9 | 13 | 3.1 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5187345 | 190470 | 0 | None | - | 1 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1216 | 32 | 9 | 13 | 3.1 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 155565680 | 175671 | 0 | None | -6 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 547 | 16 | 3 | 4 | 5.7 | N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4579190 | 175671 | 0 | None | -6 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 547 | 16 | 3 | 4 | 5.7 | N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| CHEMBL4594800 | 175671 | 0 | None | -6 | 2 | Guinea pig | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 547 | 16 | 3 | 4 | 5.7 | N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1 | 10.1039/C8MD00527C | ||
| 168283519 | 190470 | 0 | None | - | 1 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1216 | 32 | 9 | 13 | 3.1 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5187345 | 190470 | 0 | None | - | 1 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1216 | 32 | 9 | 13 | 3.1 | Cc1cc(C)n2c1C=C1C=CC(/C=C/c3ccc(OCC(=O)NCCCC[C@H](NC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCN4CCC(Oc5ccccc5Cc5ccccc5)CC4)C(C)C)C(N)=O)cc3)=[N+]1[B-]2(F)F | 10.1021/acs.jmedchem.2c00125 | ||
| 168295200 | 191791 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1321 | 33 | 10 | 15 | 5.0 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5207609 | 191791 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1321 | 33 | 10 | 15 | 5.0 | C[C@@H](O)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168276508 | 189672 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1140 | 28 | 6 | 11 | 6.9 | C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1 | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5175488 | 189672 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1140 | 28 | 6 | 11 | 6.9 | C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1 | 10.1021/acs.jmedchem.2c00125 | ||
| 2200 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.ejmech.2018.04.043 | ||
| CHEMBL1256819 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.ejmech.2018.04.043 | ||
| CHEMBL1305 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.ejmech.2018.04.043 | ||
| 1605 | 2310 | 110 | None | 1 | 4 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2015.02.037 | ||
| 3957 | 2310 | 110 | None | 1 | 4 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2015.02.037 | ||
| 7216 | 2310 | 110 | None | 1 | 4 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2015.02.037 | ||
| CHEMBL998 | 2310 | 110 | None | 1 | 4 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2015.02.037 | ||
| DB00455 | 2310 | 110 | None | 1 | 4 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2015.02.037 | ||
| 2200 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2019.02.020 | ||
| CHEMBL1256819 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2019.02.020 | ||
| CHEMBL1305 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2019.02.020 | ||
| 2200 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL1256819 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL1305 | 20003 | 57 | None | 26 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| 168296109 | 191825 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 1155 | 29 | 7 | 11 | 5.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208169 | 191825 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 1155 | 29 | 7 | 11 | 5.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 155567030 | 175843 | 0 | None | -21 | 4 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 337 | 8 | 0 | 2 | 5.8 | c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL4586133 | 175843 | 0 | None | -21 | 4 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 337 | 8 | 0 | 2 | 5.8 | c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL4596108 | 175843 | 0 | None | -21 | 4 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 337 | 8 | 0 | 2 | 5.8 | c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| 168296109 | 191825 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 1155 | 29 | 7 | 11 | 5.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5208169 | 191825 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 1155 | 29 | 7 | 11 | 5.6 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCCC(=O)N[C@@H](CCCCNC(=O)CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 1278 | 2119 | 79 | None | -288 | 8 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmc.2019.02.020 | ||
| 1279 | 2119 | 79 | None | -288 | 8 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmc.2019.02.020 | ||
| 4908365 | 2119 | 79 | None | -288 | 8 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmc.2019.02.020 | ||
| CHEMBL129198 | 2119 | 79 | None | -288 | 8 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmc.2019.02.020 | ||
| 155540474 | 175699 | 0 | None | -10 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 479 | 16 | 3 | 4 | 4.7 | N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4482871 | 175699 | 0 | None | -10 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 479 | 16 | 3 | 4 | 4.7 | N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccccc1 | 10.1039/C8MD00527C | ||
| CHEMBL4595050 | 175699 | 0 | None | -10 | 2 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 479 | 16 | 3 | 4 | 4.7 | N=C(NCCCCN1CCN(CCCCCCCOc2ccccc2)CC1)NCc1ccccc1 | 10.1039/C8MD00527C | ||
| 10873565 | 37603 | 0 | None | -1584 | 3 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 423 | 9 | 1 | 4 | 5.8 | Clc1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| CHEMBL14587 | 37603 | 0 | None | -1584 | 3 | Guinea pig | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 423 | 9 | 1 | 4 | 5.8 | Clc1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 | 10.1021/jm0110845 | ||
| 11048988 | 40708 | 0 | None | -3981 | 3 | Guinea pig | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 471 | 11 | 1 | 4 | 6.8 | c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 | 10.1021/jm0110845 | ||
| CHEMBL14868 | 40708 | 0 | None | -3981 | 3 | Guinea pig | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 471 | 11 | 1 | 4 | 6.8 | c1ccc2c(NCCCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 | 10.1021/jm0110845 | ||
| 11046028 | 152006 | 0 | None | -144 | 3 | Guinea pig | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 338 | 6 | 1 | 4 | 4.5 | C/C(=N\O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL39716 | 152006 | 0 | None | -144 | 3 | Guinea pig | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 338 | 6 | 1 | 4 | 4.5 | C/C(=N\O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| 11089134 | 21204 | 0 | None | -151 | 3 | Guinea pig | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 4.4 | O=C(NC(c1ccccc1)C1CCCCC1)OCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| CHEMBL131476 | 21204 | 0 | None | -151 | 3 | Guinea pig | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 341 | 7 | 2 | 3 | 4.4 | O=C(NC(c1ccccc1)C1CCCCC1)OCCCc1c[nH]cn1 | 10.1021/jm020910m | ||
| 9866657 | 11913 | 0 | None | -512 | 3 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 4.1 | CC(=O)c1ccc(OCc2ccc(CN3CCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL1183328 | 11913 | 0 | None | -512 | 3 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 4.1 | CC(=O)c1ccc(OCc2ccc(CN3CCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| CHEMBL290613 | 11913 | 0 | None | -512 | 3 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 4.1 | CC(=O)c1ccc(OCc2ccc(CN3CCCC3)cc2)cc1 | 10.1021/jm021084k | ||
| 26987 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| 6063 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| 671 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| CHEMBL1626 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| DB00283 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | nan | ||
| 3158 | 55974 | 21 | None | 40 | 20 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | nan | ||
| CHEMBL1628227 | 55974 | 21 | None | 40 | 20 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | nan | ||
| 15749406 | 12168 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 293 | 3 | 0 | 2 | 4.3 | Cc1ccc2c(c1)/C(=C/CCN(C)C)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| CHEMBL1184758 | 12168 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 293 | 3 | 0 | 2 | 4.3 | Cc1ccc2c(c1)/C(=C/CCN(C)C)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| CHEMBL366965 | 12168 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 293 | 3 | 0 | 2 | 4.3 | Cc1ccc2c(c1)/C(=C/CCN(C)C)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | nan | ||
| 135 | 2496 | 38 | None | -1 | 57 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | nan | ||
| 1225 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 10.1021/acs.jmedchem.2c00125 | ||
| 3958 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 10.1021/acs.jmedchem.2c00125 | ||
| 667477 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL860 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 10.1021/acs.jmedchem.2c00125 | ||
| DB01142 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 10.1021/acs.jmedchem.2c00125 | ||
| 3158 | 55974 | 21 | None | 40 | 20 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1021/jm2011589 | ||
| CHEMBL1628227 | 55974 | 21 | None | 40 | 20 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1021/jm2011589 | ||
| 1238 | 201484 | 21 | None | -38 | 16 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm100652h | ||
| CHEMBL64249 | 201484 | 21 | None | -38 | 16 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm100652h | ||
| 3158 | 55974 | 21 | None | 40 | 20 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL1628227 | 55974 | 21 | None | 40 | 20 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1021/acs.jmedchem.6b00981 | ||
| 46884735 | 7891 | 0 | None | 11481 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 4.3 | C[C@H](C1=C(CCN(C)C)Cc2cc(F)ccc21)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090527 | 7891 | 0 | None | 11481 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 4.3 | C[C@H](C1=C(CCN(C)C)Cc2cc(F)ccc21)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| 135398745 | 2869 | 108 | None | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm010982y | ||
| 47 | 2869 | 108 | None | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm010982y | ||
| CHEMBL715 | 2869 | 108 | None | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm010982y | ||
| DB00334 | 2869 | 108 | None | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm010982y | ||
| 1530 | 2151 | 44 | None | 5 | 20 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00089a020 | ||
| 3827 | 2151 | 44 | None | 5 | 20 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00089a020 | ||
| 7206 | 2151 | 44 | None | 5 | 20 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00089a020 | ||
| CHEMBL534 | 2151 | 44 | None | 5 | 20 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00089a020 | ||
| DB00920 | 2151 | 44 | None | 5 | 20 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.1021/jm00089a020 | ||
| 71452601 | 83792 | 0 | None | 100 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.5 | N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208424 | 83792 | 0 | None | 100 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 4.5 | N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 2286 | 3134 | 48 | None | -2 | 29 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| 4927 | 3134 | 48 | None | -2 | 29 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| 7282 | 3134 | 48 | None | -2 | 29 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| CHEMBL643 | 3134 | 48 | None | -2 | 29 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| DB01069 | 3134 | 48 | None | -2 | 29 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | nan | ||
| 1201549 | 590 | 22 | None | -1 | 20 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| 333 | 590 | 22 | None | -1 | 20 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| 7601 | 590 | 22 | None | -1 | 20 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL1201203 | 590 | 22 | None | -1 | 20 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL438151 | 590 | 22 | None | -1 | 20 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| DB00245 | 590 | 22 | None | -1 | 20 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | nan | ||
| 31843 | 163013 | 76 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 324 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL420316 | 163013 | 76 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 324 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4551989 | 163013 | 76 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 324 | 0 | 0 | 2 | 4.4 | CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 2284 | 3133 | 27 | None | 1 | 28 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| 4926 | 3133 | 27 | None | 1 | 28 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| 7281 | 3133 | 27 | None | 1 | 28 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| CHEMBL564 | 3133 | 27 | None | 1 | 28 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| DB00420 | 3133 | 27 | None | 1 | 28 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | nan | ||
| 12963076 | 194950 | 2 | None | 162 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm900933k | ||
| CHEMBL564226 | 194950 | 2 | None | 162 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm900933k | ||
| 10315110 | 171291 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 338 | 1 | 0 | 2 | 4.8 | CCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4469024 | 171291 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 338 | 1 | 0 | 2 | 4.8 | CCN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 277 | 1274 | 55 | None | -2 | 45 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| 2913 | 1274 | 55 | None | -2 | 45 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| 765 | 1274 | 55 | None | -2 | 45 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| CHEMBL516 | 1274 | 55 | None | -2 | 45 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| DB00434 | 1274 | 55 | None | -2 | 45 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | nan | ||
| 9839050 | 111886 | 0 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL329566 | 111886 | 0 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1021/jm049632c | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | nan | ||
| 12963076 | 194950 | 2 | None | 162 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL564226 | 194950 | 2 | None | 162 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 15749404 | 201723 | 2 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CCO)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL65612 | 201723 | 2 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CCO)cc21 | 10.1021/jm00089a020 | ||
| 10333104 | 119084 | 0 | None | 43 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 265 | 4 | 0 | 1 | 4.1 | CN(C)CCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL346230 | 119084 | 0 | None | 43 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 265 | 4 | 0 | 1 | 4.1 | CN(C)CCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 11832931 | 161242 | 1 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 283 | 3 | 1 | 2 | 3.0 | Cc1[nH]cnc1CCC(=O)N1CC(C)(C)c2ccccc21 | 10.1016/S0960-894X(00)80418-7 | ||
| CHEMBL414174 | 161242 | 1 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 283 | 3 | 1 | 2 | 3.0 | Cc1[nH]cnc1CCC(=O)N1CC(C)(C)c2ccccc21 | 10.1016/S0960-894X(00)80418-7 | ||
| 2435 | 3533 | 78 | None | -95 | 48 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm100652h | ||
| 60149 | 3533 | 78 | None | -95 | 48 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm100652h | ||
| 98 | 3533 | 78 | None | -95 | 48 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm100652h | ||
| CHEMBL12713 | 3533 | 78 | None | -95 | 48 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm100652h | ||
| DB06144 | 3533 | 78 | None | -95 | 48 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm100652h | ||
| 44401164 | 69473 | 0 | None | -2 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL193639 | 69473 | 0 | None | -2 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 277 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| 2913 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| 765 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| CHEMBL516 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| DB00434 | 1274 | 55 | None | 2 | 45 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 10.1021/jm00017a019 | ||
| 9839050 | 111886 | 0 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL329566 | 111886 | 0 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 180 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| 200 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| 2160 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| CHEMBL629 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| DB00321 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | nan | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | nan | ||
| 42631003 | 197937 | 10 | None | -2 | 8 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.ejmech.2022.114464 | ||
| CHEMBL592752 | 197937 | 10 | None | -2 | 8 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 304 | 3 | 0 | 2 | 4.2 | Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1 | 10.1016/j.ejmech.2022.114464 | ||
| 44247803 | 194412 | 0 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 5 | 0 | 1 | 4.3 | CN(C)CCC1=C(Cc2ccc(F)cc2)c2ccccc2C1 | 10.1021/jm900933k | ||
| CHEMBL560741 | 194412 | 0 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 5 | 0 | 1 | 4.3 | CN(C)CCC1=C(Cc2ccc(F)cc2)c2ccccc2C1 | 10.1021/jm900933k | ||
| 44401164 | 69473 | 0 | None | -2 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL193639 | 69473 | 0 | None | -2 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 103 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
| 2875 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
| 5736 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
| CHEMBL285802 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
| DB09225 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm0002432 | ||
| 44326705 | 111831 | 0 | None | 5 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL329268 | 111831 | 0 | None | 5 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 15749405 | 100594 | 11 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CCO)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL294777 | 100594 | 11 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 3.5 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CCO)cc21 | 10.1021/jm00089a020 | ||
| 155519275 | 169865 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 364 | 2 | 0 | 2 | 5.1 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4448535 | 169865 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 364 | 2 | 0 | 2 | 5.1 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 9839081 | 111155 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3N2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL328573 | 111155 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 294 | 2 | 0 | 3 | 3.4 | CN(C)C[C@@H]1C[C@@H]2c3ccccc3Cc3ccccc3N2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 21855 | 83830 | 35 | None | 7 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL22108 | 83830 | 35 | None | 7 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 44326319 | 205482 | 0 | None | 9 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)CC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL92667 | 205482 | 0 | None | 9 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)CC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 46884734 | 7890 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.7 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090526 | 7890 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.7 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 46884734 | 7890 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.7 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21 | 10.1016/j.bmcl.2010.07.117 | ||
| CHEMBL1090526 | 7890 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 3.7 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(F)ccc21 | 10.1016/j.bmcl.2010.07.117 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b01422 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | nan | ||
| 155567541 | 175419 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 378 | 2 | 0 | 2 | 5.5 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4588983 | 175419 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 378 | 2 | 0 | 2 | 5.5 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 46884666 | 8202 | 0 | None | 3019 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 298 | 5 | 0 | 3 | 4.2 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092598 | 8202 | 0 | None | 3019 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 298 | 5 | 0 | 3 | 4.2 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11515387 | 8217 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.1 | COc1nccnc1CC1=C(CCN(C)C)Cc2cc(F)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092651 | 8217 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 327 | 6 | 0 | 4 | 3.1 | COc1nccnc1CC1=C(CCN(C)C)Cc2cc(F)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 652557 | 59146 | 13 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 330 | 6 | 1 | 5 | 2.3 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1nccs1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL1712377 | 59146 | 13 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 330 | 6 | 1 | 5 | 2.3 | O=C(CCN1CCN(Cc2ccccc2)CC1)Nc1nccs1 | 10.1021/acs.jmedchem.8b00718 | ||
| 11759212 | 57586 | 0 | None | 40 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 326 | 5 | 0 | 2 | 4.8 | CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL167223 | 57586 | 0 | None | 40 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 326 | 5 | 0 | 2 | 4.8 | CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 135 | 2496 | 38 | None | -1 | 57 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 44247935 | 194902 | 0 | None | -2 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 294 | 5 | 0 | 3 | 4.1 | C[C@@H](c1ccccn1)c1c(CCN(C)C)oc2ccccc12 | 10.1021/jm900933k | ||
| CHEMBL563920 | 194902 | 0 | None | -2 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 294 | 5 | 0 | 3 | 4.1 | C[C@@H](c1ccccn1)c1c(CCN(C)C)oc2ccccc12 | 10.1021/jm900933k | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2013.01.044 | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 46865650 | 8201 | 0 | None | 3715 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 323 | 6 | 0 | 4 | 3.6 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2ccccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092597 | 8201 | 0 | None | 3715 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 323 | 6 | 0 | 4 | 3.6 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2ccccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 163091 | 491 | 30 | None | -6 | 10 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 10.1016/j.bmcl.2020.127681 | ||
| 22 | 491 | 30 | None | -6 | 10 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL504548 | 491 | 30 | None | -6 | 10 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 10.1016/j.bmcl.2020.127681 | ||
| 68168663 | 175122 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 1 | 0 | 2 | 5.1 | CC(C)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4582006 | 175122 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 1 | 0 | 2 | 5.1 | CC(C)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 15662541 | 67430 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 322 | 2 | 0 | 3 | 4.8 | c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2 | 10.1021/jm00017a019 | ||
| CHEMBL1908311 | 67430 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 322 | 2 | 0 | 3 | 4.8 | c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2 | 10.1021/jm00017a019 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm401958n | ||
| 4011 | 81996 | 43 | None | 6 | 23 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | nan | ||
| CHEMBL21731 | 81996 | 43 | None | 6 | 23 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | nan | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm049632c | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm049632c | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm049632c | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm049632c | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm049632c | ||
| 180 | 397 | 50 | None | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| 200 | 397 | 50 | None | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| 2160 | 397 | 50 | None | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL629 | 397 | 50 | None | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| DB00321 | 397 | 50 | None | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| 6761 | 67457 | 17 | None | -1 | 18 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | ||
| CHEMBL1909072 | 67457 | 17 | None | -1 | 18 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | nan | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | nan | ||
| 44326442 | 106636 | 0 | None | 14 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 366 | 2 | 0 | 4 | 4.0 | CN1CCN(CC2C[C@@H]3c4ccccc4Sc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL316068 | 106636 | 0 | None | 14 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 366 | 2 | 0 | 4 | 4.0 | CN1CCN(CC2C[C@@H]3c4ccccc4Sc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm049632c | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm049632c | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm049632c | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm049632c | ||
| 44401106 | 123808 | 0 | None | -1 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL363581 | 123808 | 0 | None | -1 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 44290349 | 177962 | 0 | None | 131 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 2.1 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1 | 10.1021/jm00159a017 | ||
| CHEMBL46683 | 177962 | 0 | None | 131 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 411 | 5 | 2 | 6 | 2.1 | O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3cc(O)ccc3c2=O)CC1 | 10.1021/jm00159a017 | ||
| 155536963 | 171672 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 392 | 2 | 0 | 2 | 5.9 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4474226 | 171672 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 392 | 2 | 0 | 2 | 5.9 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b00981 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b00981 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b00981 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b00981 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/acs.jmedchem.6b00981 | ||
| 46884733 | 7829 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 353 | 7 | 0 | 5 | 3.6 | COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccnc1OC | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090186 | 7829 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 353 | 7 | 0 | 5 | 3.6 | COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccnc1OC | 10.1016/j.bmcl.2010.02.055 | ||
| 44247806 | 193995 | 1 | None | 14454 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL556506 | 193995 | 1 | None | 14454 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| 44247806 | 193995 | 1 | None | 14454 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL556506 | 193995 | 1 | None | 14454 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 45272894 | 193982 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 4 | 0 | 5 | 4.3 | Fc1ccc(Cn2c(N3CCC(n4ccnc4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL556449 | 193982 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 375 | 4 | 0 | 5 | 4.3 | Fc1ccc(Cn2c(N3CCC(n4ccnc4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 44247806 | 193995 | 1 | None | 14454 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1021/jm900933k | ||
| CHEMBL556506 | 193995 | 1 | None | 14454 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1021/jm900933k | ||
| 46884670 | 8139 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 3.6 | CN(C)CCC1=C(Cc2cnccn2)c2ccc(Cl)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092259 | 8139 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 3.6 | CN(C)CCC1=C(Cc2cnccn2)c2ccc(Cl)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11702114 | 8215 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 297 | 5 | 0 | 3 | 3.1 | CN(C)CCC1=C(Cc2cnccn2)c2ccc(F)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092649 | 8215 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 297 | 5 | 0 | 3 | 3.1 | CN(C)CCC1=C(Cc2cnccn2)c2ccc(F)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11186523 | 126989 | 0 | None | 1 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL366164 | 126989 | 0 | None | 1 | 9 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.5 | CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 1027 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 3241 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 7176 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| CHEMBL1106 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| DB00751 | 1546 | 67 | None | 6 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 10.1021/jm00017a019 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | nan | ||
| 46884698 | 8216 | 0 | None | 1318 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 343 | 6 | 0 | 4 | 3.6 | COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092650 | 8216 | 0 | None | 1318 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 343 | 6 | 0 | 4 | 3.6 | COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 45272876 | 194828 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.9 | Cc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL563451 | 194828 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 348 | 4 | 0 | 4 | 3.9 | Cc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 44247806 | 193995 | 1 | None | 14454 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.07.117 | ||
| CHEMBL556506 | 193995 | 1 | None | 14454 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.5 | C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.07.117 | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.9b00447 | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.9b00447 | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.9b00447 | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 10.1021/acs.jmedchem.9b00447 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2013.01.025 | ||
| 1228 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/np50094a001 | ||
| 2763 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/np50094a001 | ||
| 5282443 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/np50094a001 | ||
| CHEMBL855 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/np50094a001 | ||
| DB00427 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/np50094a001 | ||
| 1816 | 2504 | 99 | None | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | 10.1021/jm049632c | ||
| 4205 | 2504 | 99 | None | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | 10.1021/jm049632c | ||
| 7241 | 2504 | 99 | None | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | 10.1021/jm049632c | ||
| CHEMBL654 | 2504 | 99 | None | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | 10.1021/jm049632c | ||
| DB00370 | 2504 | 99 | None | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | 10.1021/jm049632c | ||
| 2247 | 502 | 77 | None | -4 | 41 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| 249 | 502 | 77 | None | -4 | 41 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| 2603 | 502 | 77 | None | -4 | 41 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| CHEMBL296419 | 502 | 77 | None | -4 | 41 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| DB00637 | 502 | 77 | None | -4 | 41 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
| 1228 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| 2763 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| 5282443 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| CHEMBL855 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| DB00427 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 10.1021/jm00017a019 | ||
| 4011 | 81996 | 43 | None | 6 | 23 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL21731 | 81996 | 43 | None | 6 | 23 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | 10.1016/j.bmcl.2008.09.012 | ||
| 11702115 | 8220 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 297 | 5 | 0 | 3 | 3.1 | CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092662 | 8220 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 297 | 5 | 0 | 3 | 3.1 | CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11695591 | 8237 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | C[C@H](c1cccnc1F)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092765 | 8237 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | C[C@H](c1cccnc1F)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2014.12.045 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2014.12.045 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2014.12.045 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2014.12.045 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2014.12.045 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.ejmech.2014.12.045 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm401895u | ||
| 135 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm049632c | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm049632c | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm049632c | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm049632c | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | 10.1021/jm049632c | ||
| 11702115 | 8220 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 297 | 5 | 0 | 3 | 3.1 | CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1 | 10.1016/j.bmcl.2010.07.117 | ||
| CHEMBL1092662 | 8220 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 297 | 5 | 0 | 3 | 3.1 | CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1 | 10.1016/j.bmcl.2010.07.117 | ||
| 155539495 | 172277 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 394 | 4 | 0 | 2 | 6.2 | CCC(CC)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4514700 | 172277 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 394 | 4 | 0 | 2 | 6.2 | CCC(CC)CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2011.12.019 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2011.12.019 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2011.12.019 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmc.2011.12.019 | ||
| 45272875 | 194171 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | CN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL558467 | 194171 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 3.8 | CN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 4098 | 32289 | 24 | None | 1 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | nan | ||
| CHEMBL1255739 | 32289 | 24 | None | 1 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | nan | ||
| CHEMBL1411979 | 32289 | 24 | None | 1 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | nan | ||
| 44326125 | 111210 | 0 | None | 8 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 4 | 0 | 3 | 5.9 | O=C(c1ccc(F)cc1)C1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL328662 | 111210 | 0 | None | 8 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 4 | 0 | 3 | 5.9 | O=C(c1ccc(F)cc1)C1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| 2726 | 906 | 64 | None | -2 | 72 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| 621 | 906 | 64 | None | -2 | 72 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| 83 | 906 | 64 | None | -2 | 72 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| CHEMBL71 | 906 | 64 | None | -2 | 72 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| DB00477 | 906 | 64 | None | -2 | 72 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | nan | ||
| 134135966 | 153908 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 281 | 4 | 0 | 2 | 3.8 | CN1CCC(Oc2ccccc2Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3906929 | 153908 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 281 | 4 | 0 | 2 | 3.8 | CN1CCC(Oc2ccccc2Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3990109 | 153908 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 281 | 4 | 0 | 2 | 3.8 | CN1CCC(Oc2ccccc2Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| 18715379 | 9054 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 430 | 0 | 0 | 2 | 5.0 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Br)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL11001 | 9054 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 430 | 0 | 0 | 2 | 5.0 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Br)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 10177103 | 170781 | 0 | None | 12 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 368 | 9 | 1 | 3 | 4.5 | CN(CCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL446147 | 170781 | 0 | None | 12 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 368 | 9 | 1 | 3 | 4.5 | CN(CCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| 14127193 | 11181 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.4 | CCN(CC)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL1179179 | 11181 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.4 | CCN(CC)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL63596 | 11181 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.4 | CCN(CC)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1039/C2MD00311B | ||
| 1427 | 1982 | 50 | None | -5 | 26 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2020.127493 | ||
| 357 | 1982 | 50 | None | -5 | 26 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2020.127493 | ||
| 3696 | 1982 | 50 | None | -5 | 26 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2020.127493 | ||
| CHEMBL11 | 1982 | 50 | None | -5 | 26 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2020.127493 | ||
| DB00458 | 1982 | 50 | None | -5 | 26 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2020.127493 | ||
| 1524 | 2150 | 89 | None | -2 | 51 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/acs.jmedchem.2c00633 | ||
| 197 | 2150 | 89 | None | -2 | 51 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/acs.jmedchem.2c00633 | ||
| 3822 | 2150 | 89 | None | -2 | 51 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/acs.jmedchem.2c00633 | ||
| 88 | 2150 | 89 | None | -2 | 51 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/acs.jmedchem.2c00633 | ||
| CHEMBL51 | 2150 | 89 | None | -2 | 51 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/acs.jmedchem.2c00633 | ||
| DB12465 | 2150 | 89 | None | -2 | 51 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 10.1021/acs.jmedchem.2c00633 | ||
| 69260079 | 80894 | 2 | None | 63 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 463 | 6 | 1 | 5 | 4.8 | O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158834 | 80894 | 2 | None | 63 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 463 | 6 | 1 | 5 | 4.8 | O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17867053 | 98553 | 0 | None | 10 | 3 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 435 | 5 | 0 | 5 | 4.3 | Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)cc4Cl)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL280063 | 98553 | 0 | None | 10 | 3 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 435 | 5 | 0 | 5 | 4.3 | Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)cc4Cl)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 59296066 | 83679 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207663 | 83679 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295938 | 83680 | 0 | None | -7 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 7 | 3 | 5 | 3.6 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207664 | 83680 | 0 | None | -7 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 7 | 3 | 5 | 3.6 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 11335419 | 66764 | 1 | None | 11 | 6 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 7 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL187367 | 66764 | 1 | None | 11 | 6 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 295 | 7 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 15662541 | 67430 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 322 | 2 | 0 | 3 | 4.8 | c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2 | 10.1021/jm00017a019 | ||
| CHEMBL1908311 | 67430 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 322 | 2 | 0 | 3 | 4.8 | c1ccc2c(c1)Sc1ccccc1N2CC12CCN(CC1)CC2 | 10.1021/jm00017a019 | ||
| 44450154 | 95392 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 311 | 4 | 1 | 4 | 2.7 | c1ccc([C@@H](Oc2cccc3c2OCC3)[C@H]2CNCCO2)cc1 | 10.1016/j.bmcl.2008.03.050 | ||
| CHEMBL258930 | 95392 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 311 | 4 | 1 | 4 | 2.7 | c1ccc([C@@H](Oc2cccc3c2OCC3)[C@H]2CNCCO2)cc1 | 10.1016/j.bmcl.2008.03.050 | ||
| 44449768 | 95577 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 317 | 5 | 1 | 4 | 2.9 | COc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1 | 10.1016/j.bmcl.2008.03.050 | ||
| CHEMBL259765 | 95577 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 317 | 5 | 1 | 4 | 2.9 | COc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1 | 10.1016/j.bmcl.2008.03.050 | ||
| 44450212 | 95772 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 321 | 4 | 1 | 3 | 3.6 | Fc1ccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c(Cl)c1 | 10.1016/j.bmcl.2008.03.050 | ||
| CHEMBL260823 | 95772 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 321 | 4 | 1 | 3 | 3.6 | Fc1ccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c(Cl)c1 | 10.1016/j.bmcl.2008.03.050 | ||
| 44450181 | 96295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 3.1 | Fc1cccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c1F | 10.1016/j.bmcl.2008.03.050 | ||
| CHEMBL264418 | 96295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 3.1 | Fc1cccc(O[C@H](c2ccccc2)[C@H]2CNCCO2)c1F | 10.1016/j.bmcl.2008.03.050 | ||
| 44450184 | 155135 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 301 | 4 | 1 | 3 | 3.2 | Cc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1 | 10.1016/j.bmcl.2008.03.050 | ||
| CHEMBL404956 | 155135 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 301 | 4 | 1 | 3 | 3.2 | Cc1cc(F)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1 | 10.1016/j.bmcl.2008.03.050 | ||
| 10458170 | 116026 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 487 | 8 | 1 | 4 | 6.0 | O=C(O)Cc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL336198 | 116026 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 487 | 8 | 1 | 4 | 6.0 | O=C(O)Cc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 51039227 | 57455 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 5 | 0 | 3 | 3.5 | FC1CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669417 | 57455 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 5 | 0 | 3 | 3.5 | FC1CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 22621911 | 9318 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Cl)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL11159 | 9318 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Cl)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1039/C2MD00311B | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | ||
| 66615705 | 80855 | 0 | None | -19 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158779 | 80855 | 0 | None | -19 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71453204 | 80858 | 0 | None | -12 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158782 | 80858 | 0 | None | -12 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 71451392 | 80862 | 0 | None | -31 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158786 | 80862 | 0 | None | -31 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 68849581 | 80877 | 0 | None | -3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158818 | 80877 | 0 | None | -3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69347575 | 80880 | 0 | None | -10 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158821 | 80880 | 0 | None | -10 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072034 | 80896 | 0 | None | -3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158836 | 80896 | 0 | None | -3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 127036932 | 136824 | 0 | None | -3 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 274 | 7 | 1 | 1 | 4.0 | C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| CHEMBL3752900 | 136824 | 0 | None | -3 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 274 | 7 | 1 | 1 | 4.0 | C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| 127036953 | 136990 | 0 | None | -10 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 318 | 7 | 1 | 1 | 4.1 | C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| CHEMBL3754166 | 136990 | 0 | None | -10 | 22 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 318 | 7 | 1 | 1 | 4.1 | C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| 59296085 | 83794 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 506 | 8 | 2 | 7 | 3.1 | CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208426 | 83794 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 506 | 8 | 2 | 7 | 3.1 | CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 | 10.1016/j.bmcl.2012.09.113 | ||
| 57397301 | 67538 | 0 | None | -13 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 560 | 11 | 1 | 6 | 4.6 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910382 | 67538 | 0 | None | -13 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 560 | 11 | 1 | 6 | 4.6 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 12660328 | 13295 | 15 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 241 | 6 | 1 | 2 | 2.9 | CNCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL1192719 | 13295 | 15 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 241 | 6 | 1 | 2 | 2.9 | CNCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3953343 | 13295 | 15 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 241 | 6 | 1 | 2 | 2.9 | CNCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 242 | 467 | 117 | None | -23 | 51 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
| 34 | 467 | 117 | None | -23 | 51 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
| 60795 | 467 | 117 | None | -23 | 51 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/jm070516u | ||
| 23102733 | 81821 | 0 | None | -1 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 4.0 | O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171015 | 81821 | 0 | None | -1 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 511 | 6 | 1 | 5 | 4.0 | O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71458869 | 81829 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 506 | 7 | 1 | 5 | 4.6 | O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171022 | 81829 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 506 | 7 | 1 | 5 | 4.6 | O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 11709314 | 103634 | 0 | None | -100 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 307 | 5 | 0 | 2 | 4.1 | c1ccc(COc2ccc3c(c2)CCN(CC2CC2)CC3)cc1 | 10.1016/j.bmcl.2013.09.089 | ||
| CHEMBL3094114 | 103634 | 0 | None | -100 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 307 | 5 | 0 | 2 | 4.1 | c1ccc(COc2ccc3c(c2)CCN(CC2CC2)CC3)cc1 | 10.1016/j.bmcl.2013.09.089 | ||
| 10067368 | 103655 | 0 | None | -100 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 364 | 6 | 0 | 3 | 4.5 | c1ccc(N2CCc3ccc(OCCCN4CCCCC4)cc3CC2)cc1 | 10.1016/j.bmcl.2013.09.089 | ||
| CHEMBL3094214 | 103655 | 0 | None | -100 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 364 | 6 | 0 | 3 | 4.5 | c1ccc(N2CCc3ccc(OCCCN4CCCCC4)cc3CC2)cc1 | 10.1016/j.bmcl.2013.09.089 | ||
| 10064805 | 101906 | 0 | None | -54 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 4.4 | CN1CCCC1CCNc1c2c(nc3ccccc13)CCCCC2 | 10.1016/s0960-894x(03)00356-1 | ||
| CHEMBL303824 | 101906 | 0 | None | -54 | 4 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 4.4 | CN1CCCC1CCNc1c2c(nc3ccccc13)CCCCC2 | 10.1016/s0960-894x(03)00356-1 | ||
| 33630 | 178379 | 94 | None | -13 | 27 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| CHEMBL47050 | 178379 | 94 | None | -13 | 27 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| 71454295 | 83665 | 0 | None | -1258 | 7 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 536 | 8 | 0 | 6 | 5.5 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| CHEMBL2207641 | 83665 | 0 | None | -1258 | 7 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 536 | 8 | 0 | 6 | 5.5 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| 17963199 | 81858 | 0 | None | -1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 493 | 5 | 1 | 5 | 3.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171050 | 81858 | 0 | None | -1 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 493 | 5 | 1 | 5 | 3.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 25025581 | 200311 | 0 | None | -15 | 8 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 285 | 4 | 1 | 2 | 3.1 | CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 | 10.1021/jm901818u | ||
| CHEMBL608151 | 200311 | 0 | None | -15 | 8 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 285 | 4 | 1 | 2 | 3.1 | CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 | 10.1021/jm901818u | ||
| 10060425 | 54650 | 0 | None | -758 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 245 | 5 | 2 | 3 | 2.6 | O=C(Nc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16142 | 54650 | 0 | None | -758 | 2 | Guinea pig | 5.0 | pKi | = | 5 | Binding | ChEMBL | 245 | 5 | 2 | 3 | 2.6 | O=C(Nc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 14554146 | 118614 | 0 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 354 | 0 | 0 | 2 | 3.9 | CC(=O)N1CCC(=C2c3cc(F)c(F)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL342747 | 118614 | 0 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 354 | 0 | 0 | 2 | 3.9 | CC(=O)N1CCC(=C2c3cc(F)c(F)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 44334265 | 109195 | 0 | None | -50 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 368 | 8 | 1 | 6 | 2.0 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cnccn3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL322695 | 109195 | 0 | None | -50 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 368 | 8 | 1 | 6 | 2.0 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cnccn3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44304295 | 201181 | 0 | None | -2290 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 357 | 8 | 1 | 5 | 1.5 | O=C1C[C@@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62596 | 201181 | 0 | None | -2290 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 357 | 8 | 1 | 5 | 1.5 | O=C1C[C@@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304331 | 201431 | 0 | None | -2187 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 449 | 11 | 1 | 5 | 3.2 | N[C@H](CCc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64059 | 201431 | 0 | None | -2187 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 449 | 11 | 1 | 5 | 3.2 | N[C@H](CCc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304303 | 201638 | 0 | None | -776 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 371 | 8 | 1 | 5 | 1.6 | O=C(c1ccc(OCCCN2CCN(C(=O)[C@@H]3CCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64896 | 201638 | 0 | None | -776 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 371 | 8 | 1 | 5 | 1.6 | O=C(c1ccc(OCCCN2CCN(C(=O)[C@@H]3CCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 26191740 | 151050 | 8 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccc(OC3CCNCC3)cc2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3963375 | 151050 | 8 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccc(OC3CCNCC3)cc2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 11623756 | 8058 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | CC(c1cccnc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091776 | 8058 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | CC(c1cccnc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 10731042 | 98197 | 0 | None | -194 | 2 | Guinea pig | 4.0 | pKi | = | 4 | Binding | ChEMBL | 274 | 6 | 3 | 4 | 1.9 | Nc1ccc(CNC(=O)OCCCc2c[nH]cn2)cc1 | 10.1021/jm9507688 | ||
| CHEMBL277285 | 98197 | 0 | None | -194 | 2 | Guinea pig | 4.0 | pKi | = | 4 | Binding | ChEMBL | 274 | 6 | 3 | 4 | 1.9 | Nc1ccc(CNC(=O)OCCCc2c[nH]cn2)cc1 | 10.1021/jm9507688 | ||
| 44304311 | 198609 | 0 | None | -17378 | 3 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 442 | 10 | 1 | 7 | 2.2 | N[C@H](Cc1nccs1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL59733 | 198609 | 0 | None | -17378 | 3 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 442 | 10 | 1 | 7 | 2.2 | N[C@H](Cc1nccs1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304067 | 199598 | 0 | None | -43651 | 3 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 359 | 9 | 1 | 5 | 1.4 | CNCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60401 | 199598 | 0 | None | -43651 | 3 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 359 | 9 | 1 | 5 | 1.4 | CNCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44334521 | 107350 | 0 | None | -85 | 3 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 262 | 6 | 1 | 4 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL319231 | 107350 | 0 | None | -85 | 3 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 262 | 6 | 1 | 4 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 118709751 | 113042 | 0 | None | -776 | 10 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL3321792 | 113042 | 0 | None | -776 | 10 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F | 10.1016/j.bmcl.2014.07.018 | ||
| 46882664 | 5641 | 0 | None | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 494 | 8 | 2 | 8 | 3.6 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1078240 | 5641 | 0 | None | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 494 | 8 | 2 | 8 | 3.6 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| 11545813 | 180612 | 0 | None | -24 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL476109 | 180612 | 0 | None | -24 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 168284748 | 191052 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.7 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5196026 | 191052 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.7 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304308 | 102012 | 0 | None | -40 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 8 | 0 | 5 | 3.7 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(F)c3F)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL304027 | 102012 | 0 | None | -40 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 432 | 8 | 0 | 5 | 3.7 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(F)c3F)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 168284748 | 191052 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.7 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5196026 | 191052 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.7 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304357 | 198926 | 0 | None | -851 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 415 | 9 | 1 | 5 | 3.0 | CC(C)(C)C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL59931 | 198926 | 0 | None | -851 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 415 | 9 | 1 | 5 | 3.0 | CC(C)(C)C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 164614907 | 184001 | 0 | None | -323 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 378 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4848697 | 184001 | 0 | None | -323 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 378 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(F)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44267109 | 7092 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 366 | 0 | 0 | 2 | 4.6 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(C)nc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL10855 | 7092 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 366 | 0 | 0 | 2 | 4.6 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(C)nc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 21830793 | 91403 | 5 | None | -6760 | 46 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | ||
| CHEMBL2413154 | 91403 | 5 | None | -6760 | 46 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | 10.1016/j.bmc.2013.05.050 | ||
| 44304246 | 200964 | 0 | None | -12 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 11 | 0 | 5 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3occc3C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL61396 | 200964 | 0 | None | -12 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 426 | 11 | 0 | 5 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3occc3C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304310 | 201583 | 0 | None | -141 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 415 | 10 | 0 | 4 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCCC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64667 | 201583 | 0 | None | -141 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 415 | 10 | 0 | 4 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCCC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 168281746 | 192280 | 0 | None | -14454 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 365 | 6 | 4 | 5 | 1.6 | CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5184911 | 192280 | 0 | None | -14454 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 365 | 6 | 4 | 5 | 1.6 | CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221974 | 192280 | 0 | None | -14454 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 365 | 6 | 4 | 5 | 1.6 | CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 71712245 | 109821 | 0 | None | -43651 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 377 | 7 | 0 | 6 | 3.9 | Cc1nnc(-c2cccnc2)n1-c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.ejmech.2014.03.014 | ||
| CHEMBL3238445 | 109821 | 0 | None | -43651 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 377 | 7 | 0 | 6 | 3.9 | Cc1nnc(-c2cccnc2)n1-c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.ejmech.2014.03.014 | ||
| 56835171 | 69397 | 0 | None | -645 | 9 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 295 | 2 | 2 | 6 | 1.9 | Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1 | 10.1016/j.bmcl.2011.10.104 | ||
| CHEMBL1935574 | 69397 | 0 | None | -645 | 9 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 295 | 2 | 2 | 6 | 1.9 | Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1 | 10.1016/j.bmcl.2011.10.104 | ||
| 132060752 | 162376 | 0 | None | -3 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 437 | 7 | 0 | 6 | 3.4 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4174189 | 162376 | 0 | None | -3 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 437 | 7 | 0 | 6 | 3.4 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| 44304457 | 201522 | 0 | None | -354 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 376 | 10 | 0 | 5 | 3.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64408 | 201522 | 0 | None | -354 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 376 | 10 | 0 | 5 | 3.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 127026017 | 136833 | 0 | None | 12 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 415 | 5 | 1 | 6 | 3.6 | COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752972 | 136833 | 0 | None | 12 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 415 | 5 | 1 | 6 | 3.6 | COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| 12192007 | 167844 | 35 | None | -407 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 191 | 2 | 2 | 2 | 0.8 | N[C@@H](C(=O)O)C1Cc2ccccc2C1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL434785 | 167844 | 35 | None | -407 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 191 | 2 | 2 | 2 | 0.8 | N[C@@H](C(=O)O)C1Cc2ccccc2C1 | 10.1016/s0960-894x(02)00310-4 | ||
| 168275750 | 192224 | 0 | None | -72 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 332 | 6 | 3 | 4 | 1.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5175558 | 192224 | 0 | None | -72 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 332 | 6 | 3 | 4 | 1.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221581 | 192224 | 0 | None | -72 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 332 | 6 | 3 | 4 | 1.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCc2ccccc2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 867637 | 54901 | 4 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 291 | 5 | 1 | 4 | 3.0 | C=CCn1c(=N)n(CC(=O)c2ccccc2)c2ccccc21 | 10.1021/jm2011589 | ||
| CHEMBL1617548 | 54901 | 4 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 291 | 5 | 1 | 4 | 3.0 | C=CCn1c(=N)n(CC(=O)c2ccccc2)c2ccccc21 | 10.1021/jm2011589 | ||
| 164612037 | 184795 | 0 | None | -204173 | 20 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4860528 | 184795 | 0 | None | -204173 | 20 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1016/j.ejmech.2021.113190 | ||
| 44288874 | 100626 | 0 | None | -107 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 528 | 7 | 2 | 4 | 4.2 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL295001 | 100626 | 0 | None | -107 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 528 | 7 | 2 | 4 | 4.2 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| 168287539 | 190963 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 392 | 7 | 2 | 4 | 3.7 | CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 | 10.1021/acsmedchemlett.2c00100 | ||
| CHEMBL5194692 | 190963 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 392 | 7 | 2 | 4 | 3.7 | CCOc1ccc(F)cc1NC(=O)c1cc(C)ccc1NS(=O)(=O)C1CC1 | 10.1021/acsmedchemlett.2c00100 | ||
| 53326724 | 57448 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 332 | 7 | 0 | 4 | 3.8 | C[C@H](C1=C(CCN(C)CCC#N)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669410 | 57448 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 332 | 7 | 0 | 4 | 3.8 | C[C@H](C1=C(CCN(C)CCC#N)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 23381046 | 66421 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 548 | 10 | 2 | 5 | 4.7 | NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL185825 | 66421 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 548 | 10 | 2 | 5 | 4.7 | NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 168269382 | 189328 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 818 | 21 | 6 | 8 | 3.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5169902 | 189328 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 818 | 21 | 6 | 8 | 3.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304438 | 201478 | 0 | None | -100 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 420 | 13 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CSCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64235 | 201478 | 0 | None | -100 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 420 | 13 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CSCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 3570228 | 68691 | 60 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 213 | 4 | 1 | 2 | 3.0 | NCCc1ccccc1Oc1ccccc1 | 10.1021/jm2011589 | ||
| CHEMBL1923535 | 68691 | 60 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 213 | 4 | 1 | 2 | 3.0 | NCCc1ccccc1Oc1ccccc1 | 10.1021/jm2011589 | ||
| 141485890 | 172709 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 1.7 | CCN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4525456 | 172709 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 1.7 | CCN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1 | 10.1016/j.bmcl.2019.04.015 | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| 15749427 | 101589 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm300682j | ||
| CHEMBL302005 | 101589 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm300682j | ||
| 191 | 399 | 92 | None | -56 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| 201 | 399 | 92 | None | -56 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| 2170 | 399 | 92 | None | -56 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| CHEMBL1113 | 399 | 92 | None | -56 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| DB00543 | 399 | 92 | None | -56 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | nan | ||
| 11544156 | 193232 | 0 | None | -123 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.7 | CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1 | 10.1021/jm900933k | ||
| CHEMBL540982 | 193232 | 0 | None | -123 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.7 | CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1 | 10.1021/jm900933k | ||
| 15749427 | 101589 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm058225d | ||
| CHEMBL302005 | 101589 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm058225d | ||
| 15749427 | 101589 | 0 | None | -1 | 2 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00055a013 | ||
| CHEMBL302005 | 101589 | 0 | None | -1 | 2 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00055a013 | ||
| 15749427 | 101589 | 0 | None | -1 | 2 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL302005 | 101589 | 0 | None | -1 | 2 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.2 | CN(C)C/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 46884668 | 8205 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092600 | 8205 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| 24769156 | 115717 | 0 | None | -181 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 388 | 7 | 1 | 4 | 3.6 | O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1 | 10.1021/jm501119j | ||
| CHEMBL3358509 | 115717 | 0 | None | -181 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 388 | 7 | 1 | 4 | 3.6 | O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1 | 10.1021/jm501119j | ||
| 168269382 | 189328 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 818 | 21 | 6 | 8 | 3.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5169902 | 189328 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 818 | 21 | 6 | 8 | 3.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 16006492 | 97020 | 7 | None | -275 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 195 | 0 | 2 | 3 | 2.0 | CC1NC(N)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.080 | ||
| CHEMBL270177 | 97020 | 7 | None | -275 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 195 | 0 | 2 | 3 | 2.0 | CC1NC(N)=Nc2cccc(Cl)c21 | 10.1016/j.bmcl.2007.10.080 | ||
| 44334037 | 4380 | 0 | None | -199 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 450 | 9 | 1 | 7 | 3.7 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3csc(-c4cccnc4)n3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL101634 | 4380 | 0 | None | -199 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 450 | 9 | 1 | 7 | 3.7 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3csc(-c4cccnc4)n3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 95339350 | 162332 | 1 | None | 3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 277 | 4 | 0 | 4 | 1.9 | COC[C@@H](C)N1CCN(c2cccc(F)c2C#N)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4173442 | 162332 | 1 | None | 3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 277 | 4 | 0 | 4 | 1.9 | COC[C@@H](C)N1CCN(c2cccc(F)c2C#N)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| 141485895 | 174625 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 304 | 5 | 1 | 4 | 1.2 | CN1CCc2ccc(OCCCN3CCC(O)C3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4570965 | 174625 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 304 | 5 | 1 | 4 | 1.2 | CN1CCc2ccc(OCCCN3CCC(O)C3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 112936251 | 136742 | 1 | None | -1 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 359 | 5 | 1 | 5 | 3.5 | CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752085 | 136742 | 1 | None | -1 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 359 | 5 | 1 | 5 | 3.5 | CN1CCN(c2cc(-c3ccccc3)nc(NCc3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 44304991 | 201372 | 0 | None | -891 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 424 | 12 | 0 | 5 | 3.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL63631 | 201372 | 0 | None | -891 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 424 | 12 | 0 | 5 | 3.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 71525679 | 89296 | 0 | None | -794 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 272 | 3 | 2 | 6 | 1.0 | CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1 | 10.1016/j.bmcl.2013.02.091 | ||
| CHEMBL2376801 | 89296 | 0 | None | -794 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 272 | 3 | 2 | 6 | 1.0 | CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1 | 10.1016/j.bmcl.2013.02.091 | ||
| 57334553 | 90044 | 0 | None | -3715 | 13 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 484 | 7 | 0 | 6 | 6.1 | Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm400408r | ||
| CHEMBL2387229 | 90044 | 0 | None | -3715 | 13 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 484 | 7 | 0 | 6 | 6.1 | Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm400408r | ||
| 44324800 | 205220 | 0 | None | -371 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.5 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 | 10.1021/jm049619s | ||
| CHEMBL91157 | 205220 | 0 | None | -371 | 7 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.5 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 | 10.1021/jm049619s | ||
| 94496003 | 162315 | 1 | None | -20 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 331 | 5 | 1 | 5 | 2.8 | C[C@H](CNc1cncc(Cl)n1)N1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4173176 | 162315 | 1 | None | -20 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 331 | 5 | 1 | 5 | 2.8 | C[C@H](CNc1cncc(Cl)n1)N1CCN(c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| 5048 | 3084 | 57 | None | -109 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| 8924 | 3084 | 57 | None | -109 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| 9948102 | 3084 | 57 | None | -109 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| CHEMBL462605 | 3084 | 57 | None | -109 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| DB11642 | 3084 | 57 | None | -109 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| 21533446 | 69812 | 0 | None | -30 | 10 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL1940403 | 69812 | 0 | None | -30 | 10 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
| 44267115 | 9810 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 394 | 1 | 0 | 3 | 4.5 | CC(=O)c1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL11435 | 9810 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 394 | 1 | 0 | 3 | 4.5 | CC(=O)c1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 107782 | 14330 | 16 | None | 1 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | nan | ||
| 67151996 | 14330 | 16 | None | 1 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | nan | ||
| CHEMBL1201207 | 14330 | 16 | None | 1 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | nan | ||
| 127026019 | 136935 | 0 | None | 6 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 378 | 2 | 0 | 6 | 1.7 | CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753705 | 136935 | 0 | None | 6 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 378 | 2 | 0 | 6 | 1.7 | CN1CCN(c2nc3c(c(N4CCN(C)CC4)n2)-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 168276112 | 189678 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 790 | 19 | 6 | 8 | 3.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5175594 | 189678 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 790 | 19 | 6 | 8 | 3.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168276112 | 189678 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 790 | 19 | 6 | 8 | 3.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5175594 | 189678 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 790 | 19 | 6 | 8 | 3.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 45815848 | 161754 | 5 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 330 | 4 | 0 | 5 | 3.2 | CC(C)(C)c1nc(CN2CCN(Cc3ccccn3)CC2)cs1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4164366 | 161754 | 5 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 330 | 4 | 0 | 5 | 3.2 | CC(C)(C)c1nc(CN2CCN(Cc3ccccn3)CC2)cs1 | 10.1021/acs.jmedchem.8b00718 | ||
| 46884600 | 7638 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1cncc(CC2=C(CCN(C)C)Cc3ccccc32)n1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1088882 | 7638 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1cncc(CC2=C(CCN(C)C)Cc3ccccc32)n1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11277528 | 169535 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 282 | 0 | 1 | 5 | 1.6 | Cn1ccc2c1C(=O)Cn1ccnc1C2=C1CCNCC1 | 10.1021/jm049495j | ||
| CHEMBL444353 | 169535 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 282 | 0 | 1 | 5 | 1.6 | Cn1ccc2c1C(=O)Cn1ccnc1C2=C1CCNCC1 | 10.1021/jm049495j | ||
| 15749426 | 11179 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 3 | 1 | 3 | 3.3 | CN(C)C/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL1179173 | 11179 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 3 | 1 | 3 | 3.3 | CN(C)C/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL63424 | 11179 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 3 | 1 | 3 | 3.3 | CN(C)C/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 6603950 | 201633 | 9 | None | -36 | 9 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm100652h | ||
| CHEMBL64875 | 201633 | 9 | None | -36 | 9 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm100652h | ||
| 11580426 | 7862 | 3 | None | 117 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | CC(c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1090432 | 7862 | 3 | None | 117 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | CC(c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 10028980 | 24493 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 501 | 9 | 1 | 4 | 6.4 | O=C(O)CCc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL134377 | 24493 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 501 | 9 | 1 | 4 | 6.4 | O=C(O)CCc1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 135398737 | 944 | 89 | None | -2 | 91 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2015.09.045 | ||
| 38 | 944 | 89 | None | -2 | 91 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2015.09.045 | ||
| 722 | 944 | 89 | None | -2 | 91 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2015.09.045 | ||
| CHEMBL42 | 944 | 89 | None | -2 | 91 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2015.09.045 | ||
| DB00363 | 944 | 89 | None | -2 | 91 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2015.09.045 | ||
| 49836410 | 18548 | 0 | None | 3 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 2 | 1 | 2 | 4.5 | O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277678 | 18548 | 0 | None | 3 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 393 | 2 | 1 | 2 | 4.5 | O=C(O)C1(F)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 11437142 | 200919 | 1 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| CHEMBL612084 | 200919 | 1 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| 11097588 | 200452 | 1 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| CHEMBL609131 | 200452 | 1 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccc([C@H](OCCN(C)C)c2ccccc2)cc1 | 10.1021/jm00017a019 | ||
| 16202149 | 80221 | 1 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 556 | 10 | 1 | 4 | 6.8 | CC1(C)CCCN(CCCOc2ccc(C3CCN(C(=O)c4ccc(CCC(=O)O)c5ccccc45)CC3)cc2)C1 | 10.1021/jm100064d | ||
| CHEMBL2151156 | 80221 | 1 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 556 | 10 | 1 | 4 | 6.8 | CC1(C)CCCN(CCCOc2ccc(C3CCN(C(=O)c4ccc(CCC(=O)O)c5ccccc45)CC3)cc2)C1 | 10.1021/jm100064d | ||
| 71450777 | 83788 | 0 | None | 63 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.2 | N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208420 | 83788 | 0 | None | 63 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.2 | N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295926 | 83803 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208435 | 83803 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295984 | 83597 | 0 | None | -3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207279 | 83597 | 0 | None | -3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296033 | 83604 | 0 | None | -15 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 596 | 9 | 3 | 7 | 2.7 | CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207286 | 83604 | 0 | None | -15 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 596 | 9 | 3 | 7 | 2.7 | CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 71459762 | 83677 | 0 | None | -7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 452 | 8 | 3 | 5 | 3.2 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207661 | 83677 | 0 | None | -7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 452 | 8 | 3 | 5 | 3.2 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 7077 | 66625 | 24 | None | 3 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL186720 | 66625 | 24 | None | 3 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3925724 | 66625 | 24 | None | 3 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 3359700 | 142563 | 2 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.5 | c1ccc(Cc2ccccc2OCCCN2CCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3895427 | 142563 | 2 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 7 | 0 | 2 | 4.5 | c1ccc(Cc2ccccc2OCCCN2CCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 11742610 | 205301 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1ccncc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL91565 | 205301 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1ccncc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 144950987 | 179390 | 0 | None | 95 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 292 | 3 | 0 | 2 | 3.4 | CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| CHEMBL4746800 | 179390 | 0 | None | 95 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 292 | 3 | 0 | 2 | 3.4 | CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| 46884154 | 8241 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092812 | 8241 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1 | 10.1016/j.bmcl.2010.01.134 | ||
| 14885639 | 118064 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 351 | 1 | 0 | 2 | 5.4 | CC(=O)C1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL341584 | 118064 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 351 | 1 | 0 | 2 | 5.4 | CC(=O)C1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 44352308 | 116984 | 0 | None | -1479 | 12 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | ||
| CHEMBL339980 | 116984 | 0 | None | -1479 | 12 | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | ||
| 44304382 | 201611 | 0 | None | -125 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 403 | 11 | 1 | 4 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64773 | 201611 | 0 | None | -125 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 403 | 11 | 1 | 4 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 164627774 | 185983 | 0 | None | -2 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 344 | 3 | 4 | 4 | 1.4 | N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4878215 | 185983 | 0 | None | -2 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 344 | 3 | 4 | 4 | 1.4 | N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1 | 10.1016/j.ejmech.2021.113190 | ||
| 44304030 | 199277 | 0 | None | -91 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 511 | 11 | 1 | 5 | 4.4 | N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60189 | 199277 | 0 | None | -91 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 511 | 11 | 1 | 5 | 4.4 | N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 118709750 | 113041 | 0 | None | -109 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL3321791 | 113041 | 0 | None | -109 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1 | 10.1016/j.bmcl.2014.07.018 | ||
| 155564280 | 174850 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 290 | 4 | 0 | 4 | 1.0 | CN1CCc2ccc(OCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4576048 | 174850 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 290 | 4 | 0 | 4 | 1.0 | CN1CCc2ccc(OCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 45485525 | 196122 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 7 | 1 | 2 | 4.8 | Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL572034 | 196122 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 7 | 1 | 2 | 4.8 | Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 46884239 | 8351 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 299 | 5 | 0 | 4 | 3.8 | CC(c1c(CCN(C)C)sc2ccccc12)n1ccnc1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1093607 | 8351 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 299 | 5 | 0 | 4 | 3.8 | CC(c1c(CCN(C)C)sc2ccccc12)n1ccnc1 | 10.1016/j.bmcl.2010.01.134 | ||
| 57345619 | 70120 | 0 | None | -13 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 5.0 | Fc1ccc(CCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946253 | 70120 | 0 | None | -13 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 5.0 | Fc1ccc(CCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 28390601 | 162422 | 0 | None | -2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 377 | 4 | 0 | 5 | 3.9 | Cc1oc(-c2ccco2)nc1CN1CCN([C@@H]2CCc3ccccc3C2)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4175018 | 162422 | 0 | None | -2 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 377 | 4 | 0 | 5 | 3.9 | Cc1oc(-c2ccco2)nc1CN1CCN([C@@H]2CCc3ccccc3C2)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| 69347707 | 80893 | 1 | None | 5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158833 | 80893 | 1 | None | 5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072057 | 80900 | 0 | None | -5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158840 | 80900 | 0 | None | -5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 24839550 | 136791 | 14 | None | -2 | 15 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 240 | 7 | 1 | 1 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2015.12.053 | ||
| CHEMBL3752576 | 136791 | 14 | None | -2 | 15 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 240 | 7 | 1 | 1 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2015.12.053 | ||
| 59296094 | 83685 | 0 | None | -31 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 480 | 7 | 3 | 6 | 2.7 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207669 | 83685 | 0 | None | -31 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 480 | 7 | 3 | 6 | 2.7 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 9954003 | 71356 | 18 | None | -251 | 9 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 422 | 5 | 2 | 4 | 3.8 | C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O | 10.1021/jm070516u | ||
| CHEMBL196514 | 71356 | 18 | None | -251 | 9 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 422 | 5 | 2 | 4 | 3.8 | C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O | 10.1021/jm070516u | ||
| 71462389 | 81831 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171024 | 81831 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963141 | 81856 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 5 | 1 | 5 | 4.1 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171049 | 81856 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 5 | 1 | 5 | 4.1 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 168296182 | 191629 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 808 | 21 | 7 | 9 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5204985 | 191629 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 808 | 21 | 7 | 9 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 9971374 | 103649 | 0 | None | -316 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 5 | 1 | 3 | 2.6 | c1cc2c(cc1OCCCN1CCCCC1)CCNCC2 | 10.1016/j.bmcl.2013.09.089 | ||
| CHEMBL3094130 | 103649 | 0 | None | -316 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 288 | 5 | 1 | 3 | 2.6 | c1cc2c(cc1OCCCN1CCCCC1)CCNCC2 | 10.1016/j.bmcl.2013.09.089 | ||
| 50898777 | 56146 | 0 | None | -11748 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.6 | COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632158 | 56146 | 0 | None | -11748 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.6 | COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 71461541 | 83805 | 0 | None | -15 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 513 | 9 | 3 | 6 | 2.7 | CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208437 | 83805 | 0 | None | -15 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 513 | 9 | 3 | 6 | 2.7 | CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 50878551 | 90314 | 60 | None | -21 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | ||
| CHEMBL2391541 | 90314 | 60 | None | -21 | 18 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | ||
| 10662264 | 56200 | 0 | None | -812 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 304 | 7 | 2 | 5 | 2.2 | O=C(NCc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16338 | 56200 | 0 | None | -812 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 304 | 7 | 2 | 5 | 2.2 | O=C(NCc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10660952 | 97672 | 0 | None | -190 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 287 | 7 | 1 | 3 | 3.0 | CCN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL273549 | 97672 | 0 | None | -190 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 287 | 7 | 1 | 3 | 3.0 | CCN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10732219 | 98487 | 0 | None | -602 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 290 | 6 | 2 | 5 | 2.5 | O=C(Nc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL279617 | 98487 | 0 | None | -602 | 2 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 290 | 6 | 2 | 5 | 2.5 | O=C(Nc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 1204 | 1901 | 114 | None | -46 | 23 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm00002a008 | ||
| 1247 | 1901 | 114 | None | -46 | 23 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm00002a008 | ||
| 1375 | 1901 | 114 | None | -46 | 23 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm00002a008 | ||
| 774 | 1901 | 114 | None | -46 | 23 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm00002a008 | ||
| CHEMBL90 | 1901 | 114 | None | -46 | 23 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm00002a008 | ||
| DB05381 | 1901 | 114 | None | -46 | 23 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/jm00002a008 | ||
| 44304560 | 102290 | 0 | None | -9549 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 1 | 5 | 1.6 | O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL305144 | 102290 | 0 | None | -9549 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 1 | 5 | 1.6 | O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 10422468 | 202457 | 0 | None | -630 | 3 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 254 | 7 | 3 | 2 | 2.4 | CC(C)/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| CHEMBL70603 | 202457 | 0 | None | -630 | 3 | Guinea pig | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 254 | 7 | 3 | 2 | 2.4 | CC(C)/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 164620678 | 185437 | 0 | None | -199 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 374 | 7 | 4 | 4 | 2.7 | CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4870510 | 185437 | 0 | None | -199 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 374 | 7 | 4 | 4 | 2.7 | CCC(NC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 168296182 | 191629 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 808 | 21 | 7 | 9 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5204985 | 191629 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 808 | 21 | 7 | 9 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 155567030 | 175843 | 0 | None | -37 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 0 | 2 | 5.8 | c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL4586133 | 175843 | 0 | None | -37 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 0 | 2 | 5.8 | c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| CHEMBL4596108 | 175843 | 0 | None | -37 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 0 | 2 | 5.8 | c1ccc(-c2ccc(OCCCCCN3CCCCCC3)cc2)cc1 | 10.1016/j.bmc.2017.07.058 | ||
| 18337331 | 115591 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 2 | 0 | 3 | 5.5 | CC(C)COC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357035 | 115591 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 2 | 0 | 3 | 5.5 | CC(C)COC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 57403525 | 69811 | 0 | None | -85 | 10 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL1940402 | 69811 | 0 | None | -85 | 10 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
| 168295543 | 192439 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5209021 | 192439 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222929 | 192439 | 0 | None | -1 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 57390695 | 70123 | 0 | None | 3 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946257 | 70123 | 0 | None | 3 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
| 127035062 | 135928 | 0 | None | -44 | 19 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 447 | 12 | 0 | 5 | 5.2 | COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC | 10.1039/C4MD00418C | ||
| CHEMBL3735756 | 135928 | 0 | None | -44 | 19 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 447 | 12 | 0 | 5 | 5.2 | COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC | 10.1039/C4MD00418C | ||
| 53322959 | 57445 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 325 | 7 | 0 | 3 | 3.9 | C[C@H](C1=C(CCN(C)CCF)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669408 | 57445 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 325 | 7 | 0 | 3 | 3.9 | C[C@H](C1=C(CCN(C)CCF)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 11493620 | 8184 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | C[C@@H](c1ccc(F)cn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092495 | 8184 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | C[C@@H](c1ccc(F)cn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 76332519 | 104998 | 0 | None | -1 | 4 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 510 | 7 | 0 | 6 | 6.3 | O=c1oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| CHEMBL3120697 | 104998 | 0 | None | -1 | 4 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 510 | 7 | 0 | 6 | 6.3 | O=c1oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| 53324167 | 57462 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 370 | 7 | 0 | 4 | 4.5 | C[C@H](C1=C(CCN(C)Cc2ccccn2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669424 | 57462 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 370 | 7 | 0 | 4 | 4.5 | C[C@H](C1=C(CCN(C)Cc2ccccn2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 44334036 | 167229 | 0 | None | -323 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 391 | 8 | 1 | 5 | 3.0 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3ccc(C#N)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL430502 | 167229 | 0 | None | -323 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 391 | 8 | 1 | 5 | 3.0 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3ccc(C#N)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 168271050 | 189339 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 774 | 19 | 5 | 7 | 3.5 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5170060 | 189339 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 774 | 19 | 5 | 7 | 3.5 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168271050 | 189339 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 774 | 19 | 5 | 7 | 3.5 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5170060 | 189339 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 774 | 19 | 5 | 7 | 3.5 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168268827 | 192177 | 0 | None | -4 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5179906 | 192177 | 0 | None | -4 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221314 | 192177 | 0 | None | -4 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 72138721 | 161679 | 4 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 2.9 | Fc1ccccc1N1CCN(CCCNc2cncc(Cl)n2)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4163265 | 161679 | 4 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 2.9 | Fc1ccccc1N1CCN(CCCNc2cncc(Cl)n2)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| 168268853 | 192183 | 0 | None | -19 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 389 | 8 | 4 | 5 | 1.9 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5180504 | 192183 | 0 | None | -19 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 389 | 8 | 4 | 5 | 1.9 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221353 | 192183 | 0 | None | -19 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 389 | 8 | 4 | 5 | 1.9 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 164624107 | 185140 | 0 | None | -29 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 402 | 9 | 4 | 4 | 2.8 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4865765 | 185140 | 0 | None | -29 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 402 | 9 | 4 | 4 | 2.8 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44304990 | 201373 | 0 | None | -363 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 483 | 12 | 0 | 6 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)c3ccc(C#N)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL63632 | 201373 | 0 | None | -363 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 483 | 12 | 0 | 6 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(S(=O)(=O)c3ccc(C#N)cc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304066 | 201077 | 0 | None | -309 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 449 | 11 | 1 | 5 | 3.0 | CN[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62050 | 201077 | 0 | None | -309 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 449 | 11 | 1 | 5 | 3.0 | CN[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 73347825 | 92108 | 0 | None | 1 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 311 | 5 | 1 | 3 | 2.9 | COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC | 10.1016/j.bmc.2013.07.045 | ||
| CHEMBL2432046 | 92108 | 0 | None | 1 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 311 | 5 | 1 | 3 | 2.9 | COc1ccc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc1OC | 10.1016/j.bmc.2013.07.045 | ||
| 18715381 | 96902 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(Cl)nc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL269460 | 96902 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3ccc(Cl)nc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL4520788 | 212225 | 6 | None | -63 | 25 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | None | None | None | CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 | nan | ||||
| 44373221 | 54103 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 223 | 2 | 1 | 1 | 3.1 | NCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL160893 | 54103 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 223 | 2 | 1 | 1 | 3.1 | NCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 46882180 | 5764 | 0 | None | -5 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 482 | 7 | 2 | 7 | 3.7 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1079180 | 5764 | 0 | None | -5 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 482 | 7 | 2 | 7 | 3.7 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F | 10.1016/j.bmcl.2009.09.024 | ||
| 9923147 | 4980 | 0 | None | -2238 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 321 | 6 | 1 | 4 | 3.0 | N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](N)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105267 | 4980 | 0 | None | -2238 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 321 | 6 | 1 | 4 | 3.0 | N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](N)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 44326321 | 206061 | 0 | None | 2 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 295 | 2 | 0 | 3 | 4.0 | CN(C)CC1C[C@@H]2c3ccccc3Oc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL96158 | 206061 | 0 | None | 2 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 295 | 2 | 0 | 3 | 4.0 | CN(C)CC1C[C@@H]2c3ccccc3Oc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 10382839 | 116052 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 3.7 | CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL336317 | 116052 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 3.7 | CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL538750 | 116052 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 3.7 | CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 12992627 | 66911 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 570 | 7 | 2 | 5 | 5.7 | NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL188021 | 66911 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 570 | 7 | 2 | 5 | 5.7 | NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm010982y | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm010982y | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm010982y | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm010982y | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm010982y | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.02.005 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.02.005 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.02.005 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.02.005 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm058225d | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm058225d | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm058225d | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm058225d | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm058225d | ||
| 44401042 | 124309 | 0 | None | -3 | 9 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.6 | CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL364270 | 124309 | 0 | None | -3 | 9 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.6 | CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 10344845 | 24679 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 7 | 1 | 5 | 4.9 | O=C(O)c1ccc2c(c1)C(SCCN1CCN(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL134543 | 24679 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 7 | 1 | 5 | 4.9 | O=C(O)c1ccc2c(c1)C(SCCN1CCN(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 45272878 | 194188 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 448 | 7 | 0 | 6 | 4.4 | COc1ccc(Cn2c(N3CCC(N(C)CC4CCOCC4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL558663 | 194188 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 448 | 7 | 0 | 6 | 4.4 | COc1ccc(Cn2c(N3CCC(N(C)CC4CCOCC4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 45270330 | 194773 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 434 | 7 | 1 | 6 | 4.1 | COc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL563055 | 194773 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 434 | 7 | 1 | 6 | 4.1 | COc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 25184832 | 18508 | 0 | None | 2 | 5 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 349 | 2 | 1 | 3 | 3.8 | O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277312 | 18508 | 0 | None | 2 | 5 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 349 | 2 | 1 | 3 | 3.8 | O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 10.1016/j.bmcl.2011.09.001 | ||
| 44343629 | 159402 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 1 | 1 | 3 | 2.4 | O=C1CN(C2c3ccc(Cl)cc3CCc3cccnc32)CCN1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL410734 | 159402 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 1 | 1 | 3 | 2.4 | O=C1CN(C2c3ccc(Cl)cc3CCc3cccnc32)CCN1 | 10.1016/s0960-894x(98)00626-x | ||
| 10474964 | 129949 | 0 | None | -181 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 5 | 1 | 3 | 3.3 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| CHEMBL368061 | 129949 | 0 | None | -181 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 5 | 1 | 3 | 3.3 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| CHEMBL5206021 | 129949 | 0 | None | -181 | 7 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 5 | 1 | 3 | 3.3 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| 46782362 | 149918 | 24 | None | -10 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 3.9 | CS(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(C(=O)O)CC1)c1ccccc1S2 | nan | ||
| CHEMBL3954123 | 149918 | 24 | None | -10 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 3.9 | CS(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(C(=O)O)CC1)c1ccccc1S2 | nan | ||
| 11121216 | 29925 | 0 | None | -707 | 14 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
| CHEMBL138989 | 29925 | 0 | None | -707 | 14 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
| 71456045 | 83659 | 0 | None | -1995 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| CHEMBL2207635 | 83659 | 0 | None | -1995 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.6 | COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| 44334214 | 4547 | 0 | None | -2344 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 427 | 9 | 1 | 6 | 2.6 | CC(=O)c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(C#N)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL102840 | 4547 | 0 | None | -2344 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 427 | 9 | 1 | 6 | 2.6 | CC(=O)c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(C#N)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44304090 | 201261 | 0 | None | -301 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 360 | 8 | 0 | 5 | 2.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62948 | 201261 | 0 | None | -301 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 360 | 8 | 0 | 5 | 2.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 53245590 | 91967 | 38 | None | -3 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 420 | 6 | 0 | 7 | 3.9 | COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC | 10.1021/ml400176n | ||
| CHEMBL2431120 | 91967 | 38 | None | -3 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 420 | 6 | 0 | 7 | 3.9 | COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC | 10.1021/ml400176n | ||
| 16726095 | 84214 | 2 | None | -1 | 4 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 379 | 5 | 1 | 4 | 3.4 | COC(=O)C1(c2ccc(C)cc2)CC1CN1CCC(O)(c2ccccc2)CC1 | 10.1021/jm0611197 | ||
| CHEMBL222301 | 84214 | 2 | None | -1 | 4 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 379 | 5 | 1 | 4 | 3.4 | COC(=O)C1(c2ccc(C)cc2)CC1CN1CCC(O)(c2ccccc2)CC1 | 10.1021/jm0611197 | ||
| 127051844 | 140316 | 0 | None | -125 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819427 | 140316 | 0 | None | -125 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 4601 | 205020 | 29 | None | -1 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | nan | ||
| CHEMBL1201023 | 205020 | 29 | None | -1 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | nan | ||
| CHEMBL900 | 205020 | 29 | None | -1 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | nan | ||
| 168276867 | 192233 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5174278 | 192233 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221653 | 192233 | 0 | None | -1 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44304068 | 101877 | 0 | None | -89 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 441 | 10 | 1 | 5 | 3.5 | N[C@H](CC1CCCCC1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL303737 | 101877 | 0 | None | -89 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 441 | 10 | 1 | 5 | 3.5 | N[C@H](CC1CCCCC1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304760 | 201212 | 0 | None | -234 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 431 | 13 | 1 | 5 | 3.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62741 | 201212 | 0 | None | -234 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 431 | 13 | 1 | 5 | 3.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 9906978 | 42466 | 1 | None | -28 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL150161 | 42466 | 1 | None | -28 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 9906978 | 42466 | 1 | None | -28 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
| CHEMBL150161 | 42466 | 1 | None | -28 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
| 118721930 | 115594 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 3 | 0 | 2 | 5.4 | CCCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357043 | 115594 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 3 | 0 | 2 | 5.4 | CCCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 44335428 | 4915 | 0 | None | -1 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 358 | 7 | 1 | 5 | 2.6 | CCOC(=O)N1CCN(CCCOc2ccc(-c3c[nH]cn3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL104947 | 4915 | 0 | None | -1 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 358 | 7 | 1 | 5 | 2.6 | CCOC(=O)N1CCN(CCCOc2ccc(-c3c[nH]cn3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 46884641 | 7832 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2ncccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090198 | 7832 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2ncccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 12765746 | 101810 | 3 | None | -141 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm100652h | ||
| CHEMBL303313 | 101810 | 3 | None | -141 | 10 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 344 | 1 | 0 | 3 | 4.3 | CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm100652h | ||
| 11696813 | 187335 | 12 | None | -3 | 9 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 7 | 1 | 4 | 4.1 | Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1 | 10.1021/jm800689g | ||
| CHEMBL496739 | 187335 | 12 | None | -3 | 9 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 7 | 1 | 4 | 4.1 | Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1 | 10.1021/jm800689g | ||
| 44404954 | 134742 | 0 | None | 1 | 3 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL372588 | 134742 | 0 | None | 1 | 3 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 15749429 | 201224 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.0 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CCC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL62790 | 201224 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.0 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CCC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 53326727 | 57465 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 4.3 | C[C@H](C1=C(CCN(C)CC2CCOCC2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669427 | 57465 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 4.3 | C[C@H](C1=C(CCN(C)CC2CCOCC2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 9914506 | 80845 | 0 | None | -3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158769 | 80845 | 0 | None | -3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072052 | 80847 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158771 | 80847 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072081 | 80849 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158773 | 80849 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71449584 | 80884 | 1 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158825 | 80884 | 1 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69272932 | 80887 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158828 | 80887 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 17747460 | 61000 | 8 | None | -19 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm100064d | ||
| CHEMBL1767164 | 61000 | 8 | None | -19 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 640 | 14 | 0 | 6 | 7.8 | O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 | 10.1021/jm100064d | ||
| 59296114 | 83793 | 0 | None | 12 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208425 | 83793 | 0 | None | 12 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296111 | 83673 | 0 | None | -2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 480 | 7 | 3 | 5 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207658 | 83673 | 0 | None | -2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 480 | 7 | 3 | 5 | 3.4 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| 23722970 | 68678 | 20 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL1923521 | 68678 | 20 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3977546 | 68678 | 20 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 44396235 | 167972 | 1 | None | 23 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 281 | 6 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL435505 | 167972 | 1 | None | 23 | 5 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 281 | 6 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 2865 | 4079 | 67 | None | -17 | 53 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
| 59 | 4079 | 67 | None | -17 | 53 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
| 60854 | 4079 | 67 | None | -17 | 53 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
| CHEMBL708 | 4079 | 67 | None | -17 | 53 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
| DB00246 | 4079 | 67 | None | -17 | 53 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm070516u | ||
| 136229178 | 81832 | 0 | None | 19 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 516 | 5 | 1 | 6 | 4.5 | O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171025 | 81832 | 0 | None | 19 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 516 | 5 | 1 | 6 | 4.5 | O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71451671 | 81835 | 0 | None | 31 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 519 | 8 | 2 | 5 | 5.0 | O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171028 | 81835 | 0 | None | 31 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 519 | 8 | 2 | 5 | 5.0 | O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963153 | 81853 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171046 | 81853 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 10324985 | 76428 | 7 | None | -112 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 1.7 | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 | 10.1021/jm050725j | ||
| CHEMBL199824 | 76428 | 7 | None | -112 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 1.7 | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 | 10.1021/jm050725j | ||
| CHEMBL2068762 | 76428 | 7 | None | -112 | 17 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 1.7 | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 | 10.1021/jm050725j | ||
| 9913604 | 202880 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 492 | 7 | 2 | 5 | 4.4 | NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL73135 | 202880 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 492 | 7 | 2 | 5 | 4.4 | NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1 | 10.1016/j.bmcl.2004.02.005 | ||
| 9913604 | 202880 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 492 | 7 | 2 | 5 | 4.4 | NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1 | 10.1021/jm058225d | ||
| CHEMBL73135 | 202880 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 492 | 7 | 2 | 5 | 4.4 | NC(=O)N(O)CCC#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1 | 10.1021/jm058225d | ||
| 14885627 | 114322 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | CC(=O)N1CCC(=C2c3cc(Cl)ccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL334127 | 114322 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | CC(=O)N1CCC(=C2c3cc(Cl)ccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 44334368 | 108730 | 0 | None | -301 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 506 | 10 | 1 | 5 | 3.9 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Br)cc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL321709 | 108730 | 0 | None | -301 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 506 | 10 | 1 | 5 | 3.9 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Br)cc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 9848303 | 111092 | 0 | None | -501 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 | 10.1021/jm100652h | ||
| CHEMBL328187 | 111092 | 0 | None | -501 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 487 | 6 | 1 | 6 | 3.8 | Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 | 10.1021/jm100652h | ||
| 168276544 | 189727 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5176319 | 189727 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168276544 | 189727 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5176319 | 189727 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 742 | 19 | 6 | 8 | 1.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304318 | 201570 | 0 | None | -234 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.8 | C[C@@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64608 | 201570 | 0 | None | -234 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.8 | C[C@@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 118721928 | 115592 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 378 | 1 | 0 | 2 | 4.8 | C/C=C/C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357041 | 115592 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 378 | 1 | 0 | 2 | 4.8 | C/C=C/C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 1621 | 2396 | 16 | None | -301 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
| 17 | 2396 | 16 | None | -301 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
| 5761 | 2396 | 16 | None | -301 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
| CHEMBL263881 | 2396 | 16 | None | -301 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
| DB04829 | 2396 | 16 | None | -301 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | ||
| 45485535 | 195944 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 399 | 7 | 1 | 2 | 5.6 | Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL570695 | 195944 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 399 | 7 | 1 | 2 | 5.6 | Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 3151 | 1434 | 93 | None | -41 | 26 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| 945 | 1434 | 93 | None | -41 | 26 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| 965 | 1434 | 93 | None | -41 | 26 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| CHEMBL219916 | 1434 | 93 | None | -41 | 26 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| DB01184 | 1434 | 93 | None | -41 | 26 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | nan | ||
| 44395741 | 180999 | 0 | None | -10 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL476935 | 180999 | 0 | None | -10 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL558392 | 180999 | 0 | None | -10 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 44307779 | 201865 | 0 | None | -1348 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 332 | 2 | 0 | 2 | 4.7 | C(#Cc1c2c(nc3ccccc13)CCCCC2)CCN1CCCCC1 | 10.1016/s0960-894x(03)00356-1 | ||
| CHEMBL66660 | 201865 | 0 | None | -1348 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 332 | 2 | 0 | 2 | 4.7 | C(#Cc1c2c(nc3ccccc13)CCCCC2)CCN1CCCCC1 | 10.1016/s0960-894x(03)00356-1 | ||
| 168279725 | 190561 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 728 | 19 | 6 | 8 | 1.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5188589 | 190561 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 728 | 19 | 6 | 8 | 1.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168292703 | 191462 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 726 | 18 | 5 | 7 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5202570 | 191462 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 726 | 18 | 5 | 7 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44335387 | 108063 | 0 | None | -5 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL320178 | 108063 | 0 | None | -5 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 11444350 | 80853 | 0 | None | -7 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 558 | 8 | 1 | 4 | 6.3 | O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158777 | 80853 | 0 | None | -7 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 558 | 8 | 1 | 4 | 6.3 | O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71451391 | 80857 | 0 | None | -12 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 472 | 8 | 1 | 4 | 4.5 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158781 | 80857 | 0 | None | -12 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 472 | 8 | 1 | 4 | 4.5 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 16040671 | 80867 | 0 | None | -56 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158791 | 80867 | 0 | None | -56 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 127051843 | 140220 | 0 | None | -7 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818200 | 140220 | 0 | None | -7 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 168279725 | 190561 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 728 | 19 | 6 | 8 | 1.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5188589 | 190561 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 728 | 19 | 6 | 8 | 1.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168292703 | 191462 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 726 | 18 | 5 | 7 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5202570 | 191462 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 726 | 18 | 5 | 7 | 2.9 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44267106 | 98038 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 368 | 0 | 1 | 3 | 4.0 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(O)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL275993 | 98038 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 368 | 0 | 1 | 3 | 4.0 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(O)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 44304325 | 199993 | 0 | None | -74 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 389 | 11 | 1 | 4 | 3.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL60620 | 199993 | 0 | None | -74 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 389 | 11 | 1 | 4 | 3.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)NCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 10473209 | 62345 | 2 | None | -6456 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 4 | 1 | 5 | 2.6 | CNC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1 | 10.1016/j.bmcl.2013.09.090 | ||
| CHEMBL1783890 | 62345 | 2 | None | -6456 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 4 | 1 | 5 | 2.6 | CNC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1 | 10.1016/j.bmcl.2013.09.090 | ||
| 127051844 | 140316 | 0 | None | -125 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819427 | 140316 | 0 | None | -125 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 2.8 | NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 9974306 | 202769 | 0 | None | -199 | 4 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 336 | 8 | 3 | 2 | 3.4 | S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1 | 10.1021/jm00012a025 | ||
| CHEMBL72372 | 202769 | 0 | None | -199 | 4 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 336 | 8 | 3 | 2 | 3.4 | S=C(NCCCCCc1c[nH]cn1)NCc1ccc(Cl)cc1 | 10.1021/jm00012a025 | ||
| 2061019 | 54818 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 227 | 5 | 1 | 2 | 2.6 | NCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL1616890 | 54818 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 227 | 5 | 1 | 2 | 2.6 | NCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3916710 | 54818 | 17 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 227 | 5 | 1 | 2 | 2.6 | NCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 134142912 | 153985 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2cccc(OC3CCNCC3)c2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3913361 | 153985 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2cccc(OC3CCNCC3)c2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3990797 | 153985 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2cccc(OC3CCNCC3)c2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 10802230 | 56265 | 0 | None | -389 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 273 | 6 | 1 | 3 | 2.6 | CN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16404 | 56265 | 0 | None | -389 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 273 | 6 | 1 | 3 | 2.6 | CN(Cc1ccccc1)C(=O)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10358195 | 57158 | 0 | None | -1023 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.6 | O=C(Nc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16565 | 57158 | 0 | None | -1023 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.6 | O=C(Nc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10520238 | 57260 | 0 | None | -1288 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 327 | 6 | 2 | 3 | 3.3 | O=C(NCc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16654 | 57260 | 0 | None | -1288 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 327 | 6 | 2 | 3 | 3.3 | O=C(NCc1ccc(C(F)(F)F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10708894 | 98180 | 0 | None | -1202 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 293 | 6 | 2 | 3 | 2.9 | O=C(NCc1ccc(Cl)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL277149 | 98180 | 0 | None | -1202 | 2 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 293 | 6 | 2 | 3 | 2.9 | O=C(NCc1ccc(Cl)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10466840 | 202776 | 0 | None | -1584 | 4 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 240 | 7 | 3 | 2 | 2.0 | CC/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| CHEMBL72424 | 202776 | 0 | None | -1584 | 4 | Guinea pig | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 240 | 7 | 3 | 2 | 2.0 | CC/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| 164627020 | 185826 | 0 | None | -363 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 422 | 7 | 4 | 4 | 3.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4876025 | 185826 | 0 | None | -363 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 422 | 7 | 4 | 4 | 3.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 25271818 | 12858 | 52 | None | -1 | 2 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 5281071 | 12858 | 52 | None | -1 | 2 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL1189432 | 12858 | 52 | None | -1 | 2 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL1719 | 12858 | 52 | None | -1 | 2 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 44622869 | 196040 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 371 | 5 | 1 | 2 | 5.1 | Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL571390 | 196040 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 371 | 5 | 1 | 2 | 5.1 | Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 71151588 | 117755 | 0 | None | -1584 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 518 | 9 | 1 | 7 | 3.6 | NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.045 | ||
| CHEMBL3409256 | 117755 | 0 | None | -1584 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 518 | 9 | 1 | 7 | 3.6 | NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1 | 10.1016/j.ejmech.2014.12.045 | ||
| 14885632 | 20803 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 348 | 1 | 0 | 3 | 3.6 | COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL131155 | 20803 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 348 | 1 | 0 | 3 | 3.6 | COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1 | 10.1021/jm00105a069 | ||
| 44334235 | 4563 | 0 | None | -1445 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 442 | 10 | 1 | 5 | 3.4 | Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL102929 | 4563 | 0 | None | -1445 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 442 | 10 | 1 | 5 | 3.4 | Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1 | 10.1016/s0960-894x(02)00685-6 | ||
| 53318873 | 57459 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 7 | 0 | 5 | 4.1 | C[C@H](C1=C(CCN(C)Cc2ncco2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669421 | 57459 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 7 | 0 | 5 | 4.1 | C[C@H](C1=C(CCN(C)Cc2ncco2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 44335389 | 5097 | 0 | None | 3 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 8 | 0 | 6 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccccc3[N+](=O)[O-])cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105952 | 5097 | 0 | None | 3 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 413 | 8 | 0 | 6 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccccc3[N+](=O)[O-])cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168277076 | 189880 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 755 | 21 | 6 | 8 | 2.3 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5178882 | 189880 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 755 | 21 | 6 | 8 | 2.3 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304014 | 100318 | 0 | None | -1905 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 431 | 10 | 1 | 6 | 2.3 | CC(C)(C)OC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL293033 | 100318 | 0 | None | -1905 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 431 | 10 | 1 | 6 | 2.3 | CC(C)(C)OC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 168277076 | 189880 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 755 | 21 | 6 | 8 | 2.3 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5178882 | 189880 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 755 | 21 | 6 | 8 | 2.3 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 155528188 | 170755 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 3.0 | CC1CCCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4461154 | 170755 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 3.0 | CC1CCCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2 | 10.1016/j.bmcl.2019.04.015 | ||
| 44304475 | 201079 | 0 | None | -309 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 348 | 8 | 0 | 5 | 2.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62066 | 201079 | 0 | None | -309 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 348 | 8 | 0 | 5 | 2.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 164611757 | 184320 | 0 | None | -22 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 402 | 8 | 4 | 4 | 2.8 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4853107 | 184320 | 0 | None | -22 | 6 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 402 | 8 | 4 | 4 | 2.8 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44304451 | 101820 | 0 | None | -977 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 417 | 12 | 1 | 5 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL303369 | 101820 | 0 | None | -977 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 417 | 12 | 1 | 5 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 71525681 | 89298 | 0 | None | -2041 | 6 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 298 | 3 | 2 | 6 | 1.7 | CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1 | 10.1016/j.bmcl.2013.02.091 | ||
| CHEMBL2376803 | 89298 | 0 | None | -2041 | 6 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 298 | 3 | 2 | 6 | 1.7 | CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1 | 10.1016/j.bmcl.2013.02.091 | ||
| 71528209 | 86544 | 0 | None | -257 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 465 | 6 | 0 | 3 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F | 10.1021/ml300383n | ||
| CHEMBL2323582 | 86544 | 0 | None | -257 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 465 | 6 | 0 | 3 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F | 10.1021/ml300383n | ||
| 44209480 | 69827 | 0 | None | -151 | 11 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL1940418 | 69827 | 0 | None | -151 | 11 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| 3015863 | 198075 | 7 | None | 1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 225 | 5 | 1 | 1 | 3.6 | NCCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL593734 | 198075 | 7 | None | 1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 225 | 5 | 1 | 1 | 3.6 | NCCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 57402471 | 67534 | 0 | None | -15 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 469 | 8 | 1 | 5 | 4.0 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910378 | 67534 | 0 | None | -15 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 469 | 8 | 1 | 5 | 4.0 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 44304415 | 200343 | 0 | None | -7079 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 505 | 13 | 2 | 7 | 3.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CO)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60837 | 200343 | 0 | None | -7079 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 505 | 13 | 2 | 7 | 3.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CO)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304431 | 201252 | 0 | None | -724 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 566 | 14 | 1 | 7 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62903 | 201252 | 0 | None | -724 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 566 | 14 | 1 | 7 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 164619208 | 185080 | 0 | None | -588 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 378 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4864852 | 185080 | 0 | None | -588 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 378 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccccc1F | 10.1016/j.ejmech.2021.113190 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0002432 | ||
| 46884155 | 8242 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092813 | 8242 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 10075223 | 22987 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 515 | 8 | 1 | 4 | 6.7 | CC(C)(C(=O)O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL133127 | 22987 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 515 | 8 | 1 | 4 | 6.7 | CC(C)(C(=O)O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 44389302 | 122418 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 653 | 13 | 1 | 6 | 7.3 | O=C(OCc1ccccc1)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL360666 | 122418 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 653 | 13 | 1 | 6 | 7.3 | O=C(OCc1ccccc1)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 135356876 | 173502 | 0 | None | 7 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 2 | 6 | 5.5 | O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1 | 10.1021/acs.jmedchem.6b00044 | ||
| CHEMBL4544251 | 173502 | 0 | None | 7 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 2 | 6 | 5.5 | O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1 | 10.1021/acs.jmedchem.6b00044 | ||
| 14554127 | 112826 | 0 | None | -3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 380 | 2 | 0 | 2 | 5.1 | CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL331603 | 112826 | 0 | None | -3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 380 | 2 | 0 | 2 | 5.1 | CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 5624 | 32474 | 12 | None | -5 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 5 | 1 | 8 | 4.2 | Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 | nan | ||
| CHEMBL1203324 | 32474 | 12 | None | -5 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 5 | 1 | 8 | 4.2 | Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 | nan | ||
| CHEMBL141343 | 32474 | 12 | None | -5 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 5 | 1 | 8 | 4.2 | Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 | nan | ||
| 57345617 | 70113 | 0 | None | -186 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946123 | 70113 | 0 | None | -186 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 76518514 | 113038 | 0 | None | -186 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL3321788 | 113038 | 0 | None | -186 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 387 | 6 | 1 | 2 | 5.3 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| 168290077 | 190818 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 786 | 21 | 7 | 9 | 1.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192678 | 190818 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 786 | 21 | 7 | 9 | 1.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304319 | 200947 | 0 | None | -194 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.8 | C[C@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL61288 | 200947 | 0 | None | -194 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.8 | C[C@H](CN)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 132075278 | 162094 | 0 | None | -30 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 3.1 | c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4169752 | 162094 | 0 | None | -30 | 5 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 3.1 | c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1 | 10.1016/j.ejmech.2018.02.024 | ||
| 168290077 | 190818 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 786 | 21 | 7 | 9 | 1.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192678 | 190818 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 786 | 21 | 7 | 9 | 1.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 10354158 | 51859 | 0 | None | -5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 237 | 3 | 1 | 1 | 3.5 | NCCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL158780 | 51859 | 0 | None | -5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 237 | 3 | 1 | 1 | 3.5 | NCCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 155536609 | 171653 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 1.7 | CN1CCc2ccc(OCCCN3CCC(=O)CC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4474007 | 171653 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 1.7 | CN1CCc2ccc(OCCCN3CCC(=O)CC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 127051843 | 140220 | 0 | None | -7 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818200 | 140220 | 0 | None | -7 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 5 | 0 | 3 | 3.6 | N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 44304288 | 101737 | 0 | None | -831 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 386 | 11 | 0 | 4 | 3.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL302886 | 101737 | 0 | None | -831 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 386 | 11 | 0 | 4 | 3.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 46967967 | 120304 | 4 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 299 | 4 | 0 | 4 | 3.4 | c1cnc2c(c1)cc([C@@H]1CCCO1)n2CCN1CCCCC1 | 10.1021/jm2011589 | ||
| CHEMBL3557423 | 120304 | 4 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 299 | 4 | 0 | 4 | 3.4 | c1cnc2c(c1)cc([C@@H]1CCCO1)n2CCN1CCCCC1 | 10.1021/jm2011589 | ||
| 12488 | 1627 | 51 | None | -2 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| 941361 | 1627 | 51 | None | -2 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| CHEMBL30008 | 1627 | 51 | None | -2 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| DB04841 | 1627 | 51 | None | -2 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | nan | ||
| 132356 | 14508 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL1205688 | 14508 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL133778 | 14508 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 135458410 | 166636 | 0 | None | -3 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 293 | 2 | 2 | 3 | 3.5 | CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| CHEMBL429136 | 166636 | 0 | None | -3 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 293 | 2 | 2 | 3 | 3.5 | CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| 45272070 | 193614 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 4 | 0 | 5 | 4.3 | Fc1ccc(Cn2c(N3CCC(n4cccn4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL551347 | 193614 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 4 | 0 | 5 | 4.3 | Fc1ccc(Cn2c(N3CCC(n4cccn4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 4806 | 3945 | 85 | None | -5 | 13 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| 7351 | 3945 | 85 | None | -5 | 13 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| 9966051 | 3945 | 85 | None | -5 | 13 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| CHEMBL2104993 | 3945 | 85 | None | -5 | 13 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| DB09068 | 3945 | 85 | None | -5 | 13 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | 10.1021/jm101459g | ||
| 44312748 | 203057 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 7 | 2 | 5 | 3.8 | NC(=O)N(O)CCC#C[C@H]1CC[C@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL74688 | 203057 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 496 | 7 | 2 | 5 | 3.8 | NC(=O)N(O)CCC#C[C@H]1CC[C@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1 | 10.1016/j.bmcl.2004.02.005 | ||
| 44335185 | 106907 | 0 | None | -1 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 446 | 7 | 0 | 4 | 4.7 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Br)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL317900 | 106907 | 0 | None | -1 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 446 | 7 | 0 | 4 | 4.7 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Br)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168294445 | 192408 | 0 | None | 1 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.6 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208113 | 192408 | 0 | None | 1 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.6 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222768 | 192408 | 0 | None | 1 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.6 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCC2CCc3nc(N)sc3C2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168273471 | 192199 | 0 | None | -12 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 596 | 17 | 8 | 10 | 0.7 | N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5173079 | 192199 | 0 | None | -12 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 596 | 17 | 8 | 10 | 0.7 | N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221433 | 192199 | 0 | None | -12 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 596 | 17 | 8 | 10 | 0.7 | N/C(=N\C(=O)NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168273549 | 192201 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5174342 | 192201 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221438 | 192201 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 76325295 | 104997 | 0 | None | -234 | 4 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 490 | 7 | 0 | 6 | 5.9 | Cc1c(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc2c3c(c(=O)oc12)CCC3 | 10.1016/j.ejmech.2014.01.012 | ||
| CHEMBL3120696 | 104997 | 0 | None | -234 | 4 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 490 | 7 | 0 | 6 | 5.9 | Cc1c(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc2c3c(c(=O)oc12)CCC3 | 10.1016/j.ejmech.2014.01.012 | ||
| 168288713 | 190783 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 799 | 23 | 7 | 9 | 2.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192305 | 190783 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 799 | 23 | 7 | 9 | 2.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168288713 | 190783 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 799 | 23 | 7 | 9 | 2.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192305 | 190783 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 799 | 23 | 7 | 9 | 2.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 127026018 | 136967 | 0 | None | 3 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 399 | 5 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753985 | 136967 | 0 | None | 3 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 399 | 5 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)nc3c2-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 95198280 | 161542 | 0 | None | -1 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 351 | 5 | 1 | 5 | 3.4 | Cc1oc(-c2ccc3ccccc3c2)nc1CN1CCO[C@H](CCN)C1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4160967 | 161542 | 0 | None | -1 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 351 | 5 | 1 | 5 | 3.4 | Cc1oc(-c2ccc3ccccc3c2)nc1CN1CCO[C@H](CCN)C1 | 10.1021/acs.jmedchem.8b00718 | ||
| 57403981 | 70151 | 0 | None | -14 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946745 | 70151 | 0 | None | -14 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 426 | 6 | 1 | 4 | 5.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCCc1nc2ccccc2s1 | 10.1016/j.bmc.2012.01.022 | ||
| 11653679 | 180609 | 1 | None | -28 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL476108 | 180609 | 1 | None | -28 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 10251906 | 67441 | 14 | None | -1548 | 7 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 427 | 8 | 1 | 4 | 3.6 | COc1cc(CCNCc2ccccc2OC)c(OC)cc1I | 10.1016/j.bmc.2008.04.050 | ||
| CHEMBL1908863 | 67441 | 14 | None | -1548 | 7 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 427 | 8 | 1 | 4 | 3.6 | COc1cc(CCNCc2ccccc2OC)c(OC)cc1I | 10.1016/j.bmc.2008.04.050 | ||
| CHEMBL482496 | 67441 | 14 | None | -1548 | 7 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 427 | 8 | 1 | 4 | 3.6 | COc1cc(CCNCc2ccccc2OC)c(OC)cc1I | 10.1016/j.bmc.2008.04.050 | ||
| 44313266 | 202907 | 0 | None | -3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 223 | 2 | 1 | 1 | 2.9 | CNCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL73307 | 202907 | 0 | None | -3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 223 | 2 | 1 | 1 | 2.9 | CNCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 9842252 | 130921 | 14 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 296 | 1 | 2 | 4 | 1.2 | NC(=O)c1cnc2n1CCc1ccccc1C21CCNCC1 | 10.1021/jm049495j | ||
| CHEMBL369075 | 130921 | 14 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 296 | 1 | 2 | 4 | 1.2 | NC(=O)c1cnc2n1CCc1ccccc1C21CCNCC1 | 10.1021/jm049495j | ||
| CHEMBL539843 | 130921 | 14 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 296 | 1 | 2 | 4 | 1.2 | NC(=O)c1cnc2n1CCc1ccccc1C21CCNCC1 | 10.1021/jm049495j | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmc.2008.06.030 | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm030480f | ||
| 9872445 | 66446 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 556 | 6 | 2 | 5 | 5.3 | NC(=O)N(O)CCC#Cc1ccc(OCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL185905 | 66446 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 556 | 6 | 2 | 5 | 5.3 | NC(=O)N(O)CCC#Cc1ccc(OCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 1588 | 2294 | 24 | None | -51 | 43 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| 28864 | 2294 | 24 | None | -51 | 43 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| 43 | 2294 | 24 | None | -51 | 43 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| CHEMBL157138 | 2294 | 24 | None | -51 | 43 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| DB00589 | 2294 | 24 | None | -51 | 43 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | nan | ||
| 56820088 | 161569 | 5 | None | 169 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 4 | 0 | 6 | 3.5 | c1ccc(-c2nc(CN3CCCN(c4nccs4)CC3)co2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4161436 | 161569 | 5 | None | 169 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 4 | 0 | 6 | 3.5 | c1ccc(-c2nc(CN3CCCN(c4nccs4)CC3)co2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| 59652086 | 114094 | 0 | None | 85 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 8 | 2 | 6 | 3.6 | COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1 | nan | ||
| CHEMBL3337895 | 114094 | 0 | None | 85 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 8 | 2 | 6 | 3.6 | COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1 | nan | ||
| 44288945 | 168349 | 0 | None | -47 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 485 | 7 | 2 | 3 | 4.4 | CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL43860 | 168349 | 0 | None | -47 | 7 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 485 | 7 | 2 | 3 | 4.4 | CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| 57334102 | 90077 | 0 | None | -5 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 450 | 7 | 0 | 6 | 5.4 | Cc1cc(=O)oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm400408r | ||
| CHEMBL2387260 | 90077 | 0 | None | -5 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 450 | 7 | 0 | 6 | 5.4 | Cc1cc(=O)oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm400408r | ||
| 71462102 | 80876 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158817 | 80876 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 4.4 | O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71456725 | 80886 | 1 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158827 | 80886 | 1 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71463288 | 83789 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 441 | 8 | 1 | 5 | 5.0 | COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208421 | 83789 | 0 | None | 6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 441 | 8 | 1 | 5 | 5.0 | COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296064 | 83791 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 3.5 | N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208423 | 83791 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 3.5 | N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296000 | 83800 | 0 | None | -7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 478 | 6 | 3 | 6 | 3.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208432 | 83800 | 0 | None | -7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 478 | 6 | 3 | 6 | 3.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295982 | 83600 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 568 | 8 | 4 | 7 | 2.1 | NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207282 | 83600 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 568 | 8 | 4 | 7 | 2.1 | NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295925 | 83687 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 567 | 8 | 3 | 7 | 2.9 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207671 | 83687 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 567 | 8 | 3 | 7 | 2.9 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 71723301 | 90578 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 392 | 1 | 0 | 2 | 6.1 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL2396897 | 90578 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 392 | 1 | 0 | 2 | 6.1 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 25147772 | 172837 | 4 | None | -6 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 3.7 | CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1 | 10.1021/jm800876b | ||
| CHEMBL452847 | 172837 | 4 | None | -6 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 3.7 | CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1 | 10.1021/jm800876b | ||
| 134151839 | 152445 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 7 | 0 | 2 | 4.9 | c1ccc(Cc2ccccc2OCCCN2CCCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3975229 | 152445 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 7 | 0 | 2 | 4.9 | c1ccc(Cc2ccccc2OCCCN2CCCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 49836637 | 18491 | 0 | None | 1 | 4 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 2 | 1 | 3 | 4.5 | O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277126 | 18491 | 0 | None | 1 | 4 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 375 | 2 | 1 | 3 | 4.5 | O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 71458868 | 81820 | 0 | None | -6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 568 | 6 | 1 | 6 | 4.8 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171014 | 81820 | 0 | None | -6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 568 | 6 | 1 | 6 | 4.8 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 17963363 | 81842 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171035 | 81842 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963196 | 81843 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171036 | 81843 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963258 | 81844 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171037 | 81844 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963332 | 81847 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171040 | 81847 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 4.4 | COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963336 | 81851 | 0 | None | 5 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 536 | 5 | 1 | 6 | 4.3 | N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171044 | 81851 | 0 | None | 5 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 536 | 5 | 1 | 6 | 4.3 | N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963201 | 81854 | 0 | None | -31 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 539 | 5 | 1 | 5 | 5.0 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171047 | 81854 | 0 | None | -31 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 539 | 5 | 1 | 5 | 5.0 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 14885626 | 31956 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 1 | 0 | 2 | 5.6 | O=C(c1ccccc1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL140924 | 31956 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 1 | 0 | 2 | 5.6 | O=C(c1ccccc1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 14885631 | 34716 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 332 | 0 | 0 | 2 | 3.9 | CC(=O)N1CCC(=C2c3ccc(C)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL143242 | 34716 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 332 | 0 | 0 | 2 | 3.9 | CC(=O)N1CCC(=C2c3ccc(C)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 135986088 | 177541 | 0 | None | -57 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 543 | 7 | 1 | 6 | 6.5 | Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL464811 | 177541 | 0 | None | -57 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 543 | 7 | 1 | 6 | 6.5 | Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2 | 10.1016/j.bmcl.2008.09.012 | ||
| 44312371 | 105004 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 492 | 6 | 2 | 5 | 4.4 | CC(C#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1)N(O)C(N)=O | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL312082 | 105004 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 492 | 6 | 2 | 5 | 4.4 | CC(C#Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1)N(O)C(N)=O | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL4576555 | 212264 | 3 | None | -1 | 14 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 | nan | ||||
| 44304558 | 100550 | 0 | None | -602 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 374 | 11 | 0 | 4 | 3.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL294502 | 100550 | 0 | None | -602 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 374 | 11 | 0 | 4 | 3.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 4023 | 196 | 19 | None | -660 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 349 | 7 | 0 | 4 | 3.6 | N#Cc1ccc(cc1)c1ccc(cc1)OCCCN1CC[C@H](C1)N(C)C | 10.1016/s0960-894x(02)00648-0 | ||
| 9884746 | 196 | 19 | None | -660 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 349 | 7 | 0 | 4 | 3.6 | N#Cc1ccc(cc1)c1ccc(cc1)OCCCN1CC[C@H](C1)N(C)C | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL319000 | 196 | 19 | None | -660 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 349 | 7 | 0 | 4 | 3.6 | N#Cc1ccc(cc1)c1ccc(cc1)OCCCN1CC[C@H](C1)N(C)C | 10.1016/s0960-894x(02)00648-0 | ||
| 127026016 | 136964 | 0 | None | 13 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 385 | 4 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753967 | 136964 | 0 | None | 13 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 385 | 4 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCc3ccccc3)nc3c2-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 649745 | 31267 | 50 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 303 | 3 | 1 | 7 | 0.5 | C1CCN(c2nc(N3CCCC3)nc(N3CCNCC3)n2)C1 | 10.1021/jm2011589 | ||
| CHEMBL1403257 | 31267 | 50 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 303 | 3 | 1 | 7 | 0.5 | C1CCN(c2nc(N3CCCC3)nc(N3CCNCC3)n2)C1 | 10.1021/jm2011589 | ||
| 44304450 | 201179 | 0 | None | -239 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 417 | 12 | 1 | 5 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62592 | 201179 | 0 | None | -239 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 417 | 12 | 1 | 5 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 162665485 | 181775 | 0 | None | -58 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 468 | 4 | 0 | 3 | 5.3 | C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL4784751 | 181775 | 0 | None | -58 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 468 | 4 | 0 | 3 | 5.3 | C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| 112936357 | 136834 | 1 | None | 18 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 373 | 6 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752978 | 136834 | 1 | None | 18 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 373 | 6 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)cc(-c3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 127035837 | 136892 | 0 | None | 5 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 403 | 4 | 1 | 5 | 3.7 | CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753334 | 136892 | 0 | None | 5 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 403 | 4 | 1 | 5 | 3.7 | CN1CCN(c2nc(NCc3ccc(F)cc3)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 164626370 | 185891 | 0 | None | -1 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.8 | CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4876799 | 185891 | 0 | None | -1 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.8 | CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1 | 10.1016/j.ejmech.2021.113190 | ||
| 18382725 | 115590 | 24 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 412 | 2 | 0 | 4 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(OC)cnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357024 | 115590 | 24 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 412 | 2 | 0 | 4 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(OC)cnc32)CC1 | 10.1021/jm501086v | ||
| 10398175 | 179511 | 6 | None | -6 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 209 | 1 | 1 | 1 | 2.7 | NCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL47482 | 179511 | 6 | None | -6 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 209 | 1 | 1 | 1 | 2.7 | NCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 162644910 | 178831 | 0 | None | -18 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 407 | 7 | 0 | 4 | 5.0 | Clc1cccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)c1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4740135 | 178831 | 0 | None | -18 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 407 | 7 | 0 | 4 | 5.0 | Clc1cccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)c1 | 10.1016/j.ejmech.2020.113041 | ||
| 46882181 | 5605 | 0 | None | 1 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 536 | 10 | 2 | 8 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1077908 | 5605 | 0 | None | 1 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 536 | 10 | 2 | 8 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| 66615691 | 80865 | 0 | None | -125 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 518 | 8 | 1 | 4 | 5.9 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158789 | 80865 | 0 | None | -125 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 518 | 8 | 1 | 4 | 5.9 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 59296109 | 83796 | 0 | None | -12 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 3.0 | CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208428 | 83796 | 0 | None | -12 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 3.0 | CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 127051845 | 140198 | 0 | None | -12 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3817898 | 140198 | 0 | None | -12 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 71462391 | 81839 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 3.9 | CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171032 | 81839 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 3.9 | CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 46881463 | 7139 | 0 | None | -501 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 293 | 3 | 1 | 2 | 2.7 | O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1 | 10.1016/j.bmcl.2010.01.090 | ||
| CHEMBL1085672 | 7139 | 0 | None | -501 | 5 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 293 | 3 | 1 | 2 | 2.7 | O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1 | 10.1016/j.bmcl.2010.01.090 | ||
| 9798145 | 103656 | 0 | None | -3981 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 342 | 7 | 0 | 3 | 3.8 | c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CC1)CC2 | 10.1016/j.bmcl.2013.09.089 | ||
| CHEMBL3094215 | 103656 | 0 | None | -3981 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 342 | 7 | 0 | 3 | 3.8 | c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CC1)CC2 | 10.1016/j.bmcl.2013.09.089 | ||
| 10429386 | 103657 | 0 | None | -3981 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 372 | 7 | 0 | 4 | 3.5 | c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CCCO1)CC2 | 10.1016/j.bmcl.2013.09.089 | ||
| CHEMBL3094216 | 103657 | 0 | None | -3981 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 372 | 7 | 0 | 4 | 3.5 | c1cc2c(cc1OCCCN1CCCCC1)CCN(CC1CCCO1)CC2 | 10.1016/j.bmcl.2013.09.089 | ||
| 44304294 | 201274 | 0 | None | -9 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 3.9 | N[C@H](Cc1cccc2ccccc12)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL63003 | 201274 | 0 | None | -9 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 3.9 | N[C@H](Cc1cccc2ccccc12)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 10565409 | 51910 | 0 | None | -977 | 2 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 290 | 6 | 2 | 5 | 2.5 | O=C(Nc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL15883 | 51910 | 0 | None | -977 | 2 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 290 | 6 | 2 | 5 | 2.5 | O=C(Nc1ccc([N+](=O)[O-])cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 5250783 | 168821 | 3 | None | -1995 | 3 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 226 | 6 | 3 | 2 | 1.6 | C/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| CHEMBL44220 | 168821 | 3 | None | -1995 | 3 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 226 | 6 | 3 | 2 | 1.6 | C/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1210 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 1213 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 2725 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 33036 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 4411 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 616 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 6976 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 716121 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 90475904 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL1201353 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL1554789 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL505 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| DB01114 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| DB13679 | 905 | 45 | None | -7 | 20 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(03)00357-3 | ||
| 1400 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2018.04.059 | ||
| 3658 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2018.04.059 | ||
| 7199 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2018.04.059 | ||
| 91513 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2018.04.059 | ||
| CHEMBL896 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2018.04.059 | ||
| DB00557 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2018.04.059 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm401958n | ||
| 2247 | 502 | 77 | None | -4 | 41 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| 249 | 502 | 77 | None | -4 | 41 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| 2603 | 502 | 77 | None | -4 | 41 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL296419 | 502 | 77 | None | -4 | 41 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| DB00637 | 502 | 77 | None | -4 | 41 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1016/j.bmcl.2011.09.001 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm2011589 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm2011589 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm2011589 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm2011589 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm2011589 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm2011589 | ||
| 11688223 | 8218 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 3.6 | CN(C)CCC1=C(Cc2cccnn2)c2ccc(Cl)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092652 | 8218 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 3.6 | CN(C)CCC1=C(Cc2cccnn2)c2ccc(Cl)cc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm030480f | ||
| 155561547 | 175083 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 364 | 1 | 0 | 2 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4581343 | 175083 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 364 | 1 | 0 | 2 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 46884639 | 7644 | 0 | None | 6918 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 309 | 6 | 0 | 4 | 3.0 | COc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1088900 | 7644 | 0 | None | 6918 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 309 | 6 | 0 | 4 | 3.0 | COc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 46884736 | 7892 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 312 | 5 | 0 | 3 | 4.5 | Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090528 | 7892 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 312 | 5 | 0 | 3 | 4.5 | Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| 45272046 | 193491 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 396 | 7 | 0 | 5 | 3.8 | COCCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL550337 | 193491 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 396 | 7 | 0 | 5 | 3.8 | COCCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1021/jm8007618 | ||
| 44326390 | 206111 | 0 | None | 11 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 2 | 0 | 3 | 3.5 | c1ccc2c(c1)Cc1ccccc1[C@H]1CC(CN3CCOCC3)O[C@H]21 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL96429 | 206111 | 0 | None | 11 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 335 | 2 | 0 | 3 | 3.5 | c1ccc2c(c1)Cc1ccccc1[C@H]1CC(CN3CCOCC3)O[C@H]21 | 10.1016/j.bmcl.2004.03.069 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | ||
| 15595033 | 193405 | 13 | None | 416 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 3.4 | CNC1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL549599 | 193405 | 13 | None | 416 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 3.4 | CNC1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 45272877 | 194172 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 5 | 0 | 5 | 3.6 | COc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL558468 | 194172 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 5 | 0 | 5 | 3.6 | COc1ccc(Cn2c(N3CCC(N(C)C)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 45268662 | 194276 | 0 | None | 37 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 442 | 7 | 0 | 4 | 5.4 | CN(CCc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL559557 | 194276 | 0 | None | 37 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 442 | 7 | 0 | 4 | 5.4 | CN(CCc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 46865978 | 8354 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 328 | 6 | 0 | 4 | 4.2 | COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1093623 | 8354 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 328 | 6 | 0 | 4 | 4.2 | COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1 | 10.1016/j.bmcl.2010.02.055 | ||
| 49782792 | 17729 | 0 | None | -7 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 3 | 1 | 4 | 3.3 | CC(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| CHEMBL1259174 | 17729 | 0 | None | -7 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 3 | 1 | 4 | 3.3 | CC(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| 59296081 | 83669 | 0 | None | -7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 608 | 9 | 3 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207654 | 83669 | 0 | None | -7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 608 | 9 | 3 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295978 | 83671 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207656 | 83671 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295968 | 83672 | 0 | None | -3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207657 | 83672 | 0 | None | -3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 487 | 7 | 3 | 5 | 3.3 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 155556183 | 173916 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 406 | 2 | 0 | 2 | 6.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4554533 | 173916 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 406 | 2 | 0 | 2 | 6.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 134134675 | 154046 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 315 | 4 | 0 | 2 | 4.4 | CN1CCC(Oc2ccccc2Cc2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3905009 | 154046 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 315 | 4 | 0 | 2 | 4.4 | CN1CCC(Oc2ccccc2Cc2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3991348 | 154046 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 315 | 4 | 0 | 2 | 4.4 | CN1CCC(Oc2ccccc2Cc2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| 17963227 | 81819 | 0 | None | 39 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 539 | 5 | 0 | 5 | 5.1 | Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171013 | 81819 | 0 | None | 39 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 539 | 5 | 0 | 5 | 5.1 | Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | nan | ||
| 136152971 | 94913 | 0 | None | -1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 293 | 2 | 2 | 3 | 3.5 | C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| CHEMBL256694 | 94913 | 0 | None | -1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 293 | 2 | 2 | 3 | 3.5 | C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21 | 10.1016/j.bmcl.2007.10.078 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm030480f | ||
| 46884732 | 7828 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 337 | 6 | 0 | 4 | 3.9 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090176 | 7828 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 337 | 6 | 0 | 4 | 3.9 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 46884152 | 8168 | 0 | None | 812 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | C[C@@H](c1ncccc1F)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092377 | 8168 | 0 | None | 812 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | C[C@@H](c1ncccc1F)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 10102 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 10.1016/j.bmcl.2009.05.086 | ||
| 1824 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 10.1016/j.bmcl.2009.05.086 | ||
| 65906 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL94454 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 10.1016/j.bmcl.2009.05.086 | ||
| DB12523 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 10.1016/j.bmcl.2009.05.086 | ||
| 9857902 | 60480 | 0 | None | 6 | 5 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 311 | 1 | 0 | 4 | 3.5 | Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2 | 10.1021/jm0309811 | ||
| CHEMBL176169 | 60480 | 0 | None | 6 | 5 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 311 | 1 | 0 | 4 | 3.5 | Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2 | 10.1021/jm0309811 | ||
| 9796255 | 128526 | 0 | None | -2 | 8 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 297 | 1 | 0 | 4 | 3.2 | CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1 | 10.1021/jm0309811 | ||
| CHEMBL367045 | 128526 | 0 | None | -2 | 8 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 297 | 1 | 0 | 4 | 3.2 | CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1 | 10.1021/jm0309811 | ||
| 46884732 | 7828 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 337 | 6 | 0 | 4 | 3.9 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21 | 10.1016/j.bmcl.2010.07.117 | ||
| CHEMBL1090176 | 7828 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 337 | 6 | 0 | 4 | 3.9 | COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc21 | 10.1016/j.bmcl.2010.07.117 | ||
| 2274 | 3124 | 53 | None | -3 | 32 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 4917 | 3124 | 53 | None | -3 | 32 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 7279 | 3124 | 53 | None | -3 | 32 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| CHEMBL728 | 3124 | 53 | None | -3 | 32 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| DB00433 | 3124 | 53 | None | -3 | 32 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 53318872 | 57451 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 305 | 5 | 0 | 3 | 3.5 | c1ccc2c(c1)CC(CCN1CCCC1)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669413 | 57451 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 305 | 5 | 0 | 3 | 3.5 | c1ccc2c(c1)CC(CCN1CCCC1)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmc.2008.06.030 | ||
| 45273833 | 194215 | 0 | None | 977 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 420 | 5 | 0 | 4 | 5.5 | CN(C1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL558933 | 194215 | 0 | None | 977 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 420 | 5 | 0 | 4 | 5.5 | CN(C1CCCCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | nan | ||
| 46884200 | 8238 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 344 | 5 | 0 | 3 | 5.2 | C[C@H](c1cccnc1Cl)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092766 | 8238 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 344 | 5 | 0 | 3 | 5.2 | C[C@H](c1cccnc1Cl)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 11695811 | 8306 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1093294 | 8306 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1ncccc1[C@@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 45272890 | 194227 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 409 | 7 | 0 | 5 | 3.7 | CN(C)CCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL559061 | 194227 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 409 | 7 | 0 | 5 | 3.7 | CN(C)CCN(C)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0309811 | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0309811 | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0309811 | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0309811 | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm0309811 | ||
| 44266958 | 96792 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 1 | 3 | 3.8 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(CO)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL268695 | 96792 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 1 | 3 | 3.8 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(CO)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 11485192 | 201433 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL64067 | 201433 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2020.127681 | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2020.127681 | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2020.127681 | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2020.127681 | ||
| 9419 | 35693 | 29 | None | 125 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 3 | 0 | 3 | 3.0 | CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| CHEMBL1442422 | 35693 | 29 | None | 125 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 295 | 3 | 0 | 3 | 3.0 | CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| 71450058 | 82162 | 0 | None | 37 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCCC(Cc3ccccc3)C1)c1ccccc1CO2 | 10.1021/jm300682j | ||
| CHEMBL2178582 | 82162 | 0 | None | 37 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCCC(Cc3ccccc3)C1)c1ccccc1CO2 | 10.1021/jm300682j | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | nan | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | nan | ||
| 9863340 | 161478 | 0 | None | -5 | 4 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 4.0 | Cn1c(=O)sc2cc(CCN3CCC(c4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL415985 | 161478 | 0 | None | -5 | 4 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 4 | 0 | 4 | 4.0 | Cn1c(=O)sc2cc(CCN3CCC(c4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 45485473 | 195659 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 457 | 9 | 1 | 4 | 5.4 | COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL568892 | 195659 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 457 | 9 | 1 | 4 | 5.4 | COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 44404954 | 134742 | 0 | None | -1 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm058225d | ||
| CHEMBL372588 | 134742 | 0 | None | -1 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C\CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm058225d | ||
| 9937936 | 22913 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL133080 | 22913 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.6 | O=C(O)Cc1ccc2c(c1)/C(=C/CN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 10049865 | 24544 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 6.0 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(c3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL134424 | 24544 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 6.0 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(c3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 44326405 | 111096 | 0 | None | 6 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 309 | 2 | 0 | 3 | 3.8 | CN(C)CC1C[C@@H]2c3ccccc3COc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL328209 | 111096 | 0 | None | 6 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 309 | 2 | 0 | 3 | 3.8 | CN(C)CC1C[C@@H]2c3ccccc3COc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 71212556 | 143030 | 0 | None | -7 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 433 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2 | nan | ||
| CHEMBL3899169 | 143030 | 0 | None | -7 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 433 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2 | nan | ||
| 524022 | 31429 | 1 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 0 | 0 | 2 | 3.6 | CC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL140483 | 31429 | 1 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 318 | 0 | 0 | 2 | 3.6 | CC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 71452695 | 78273 | 0 | None | -5011 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 453 | 10 | 1 | 6 | 3.0 | N#Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL2112451 | 78273 | 0 | None | -5011 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 453 | 10 | 1 | 6 | 3.0 | N#Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44270248 | 47709 | 0 | None | - | 1 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 305 | 3 | 1 | 5 | 1.8 | C[C@H]1CN(CCc2ccc3c(c2)sc(=O)n3C)C[C@@H](C)N1 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL15499 | 47709 | 0 | None | - | 1 | Rat | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 305 | 3 | 1 | 5 | 1.8 | C[C@H]1CN(CCc2ccc3c(c2)sc(=O)n3C)C[C@@H](C)N1 | 10.1016/s0960-894x(02)00123-3 | ||
| 10156707 | 200955 | 0 | None | -6 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 381 | 9 | 3 | 3 | 4.6 | N=C(CCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL61348 | 200955 | 0 | None | -6 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 381 | 9 | 3 | 3 | 4.6 | N=C(CCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| 10456093 | 195832 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 9 | 2 | 3 | 5.4 | O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL570033 | 195832 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 9 | 2 | 3 | 5.4 | O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 44304377 | 201089 | 0 | None | -112 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 424 | 11 | 0 | 6 | 3.5 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnccn3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62115 | 201089 | 0 | None | -112 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 424 | 11 | 0 | 6 | 3.5 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnccn3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44591134 | 175626 | 0 | None | -169 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL459373 | 175626 | 0 | None | -169 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 2712 | 903 | 33 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| 3370 | 903 | 33 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| 594 | 903 | 33 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| CHEMBL451 | 903 | 33 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| DB00475 | 903 | 33 | None | -5 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | nan | ||
| 44304309 | 168650 | 0 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 8 | 0 | 5 | 3.6 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(F)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL440864 | 168650 | 0 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 414 | 8 | 0 | 5 | 3.6 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(F)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304211 | 101727 | 0 | None | -6918 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.9 | CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL302829 | 101727 | 0 | None | -6918 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.9 | CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 127035835 | 136761 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 385 | 4 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752270 | 136761 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 385 | 4 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCc3ccccc3)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 71519674 | 89299 | 0 | None | -2454 | 5 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 270 | 3 | 2 | 6 | 0.9 | CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1 | 10.1016/j.bmcl.2013.02.091 | ||
| CHEMBL2376804 | 89299 | 0 | None | -2454 | 5 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 270 | 3 | 2 | 6 | 0.9 | CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1 | 10.1016/j.bmcl.2013.02.091 | ||
| 14554138 | 110173 | 33 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 1 | 0 | 2 | 3.9 | O=CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL325909 | 110173 | 33 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 338 | 1 | 0 | 2 | 3.9 | O=CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm0002432 | ||
| 57334707 | 90045 | 0 | None | -4 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 464 | 7 | 0 | 6 | 5.7 | Cc1cc(=O)oc2c(C)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm400408r | ||
| CHEMBL2387230 | 90045 | 0 | None | -4 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 464 | 7 | 0 | 6 | 5.7 | Cc1cc(=O)oc2c(C)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12 | 10.1021/jm400408r | ||
| 56966478 | 104989 | 0 | None | 1 | 4 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 0 | 6 | 5.6 | O=c1oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| CHEMBL3120688 | 104989 | 0 | None | 1 | 4 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 0 | 6 | 5.6 | O=c1oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc2c2c1CCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| 9844271 | 130160 | 1 | None | -1 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 333 | 1 | 0 | 4 | 3.6 | CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm010982y | ||
| CHEMBL368324 | 130160 | 1 | None | -1 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 333 | 1 | 0 | 4 | 3.6 | CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm010982y | ||
| 9844271 | 130160 | 1 | None | -1 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 333 | 1 | 0 | 4 | 3.6 | CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm0309811 | ||
| CHEMBL368324 | 130160 | 1 | None | -1 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 333 | 1 | 0 | 4 | 3.6 | CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1 | 10.1021/jm0309811 | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm400408r | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm400408r | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm400408r | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm400408r | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm400408r | ||
| 44267047 | 9315 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 398 | 1 | 0 | 3 | 5.0 | CSc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL11158 | 9315 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 398 | 1 | 0 | 3 | 5.0 | CSc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 1353 | 1880 | 85 | None | -602 | 85 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
| 3559 | 1880 | 85 | None | -602 | 85 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
| 86 | 1880 | 85 | None | -602 | 85 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
| CHEMBL54 | 1880 | 85 | None | -602 | 85 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
| DB00502 | 1880 | 85 | None | -602 | 85 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | ||
| 57401706 | 69828 | 0 | None | -37 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL1940419 | 69828 | 0 | None | -37 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| 57398985 | 67541 | 0 | None | -16 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 569 | 12 | 2 | 7 | 4.4 | COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910385 | 67541 | 0 | None | -16 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 569 | 12 | 2 | 7 | 4.4 | COc1ccc(CN(CCN(C)CC(C)Nc2ccc3[nH]c(C(=O)N4CCN(C)CC4)cc3c2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 168268680 | 192164 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5172675 | 192164 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221210 | 192164 | 0 | None | -1 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 662 | 11 | 8 | 8 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCCCCCCNC(=O)/N=C(\N)Nc2ccc(-c3sc(N)nc3C)cc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44304437 | 100527 | 0 | None | -371 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 404 | 11 | 1 | 5 | 3.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)(C)O)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL294349 | 100527 | 0 | None | -371 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 404 | 11 | 1 | 5 | 3.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)(C)O)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304393 | 105477 | 0 | None | -218 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 517 | 13 | 1 | 6 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL312958 | 105477 | 0 | None | -218 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 517 | 13 | 1 | 6 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 164622330 | 185280 | 0 | None | -870 | 6 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 2.3 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4867962 | 185280 | 0 | None | -870 | 6 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 2.3 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4531334 | 212233 | 21 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 | nan | ||||
| 127051845 | 140198 | 0 | None | -12 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3817898 | 140198 | 0 | None | -12 | 9 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 309 | 6 | 0 | 3 | 3.7 | COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 10066369 | 119752 | 0 | None | -8 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 348 | 7 | 0 | 2 | 5.7 | CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL352375 | 119752 | 0 | None | -8 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 348 | 7 | 0 | 2 | 5.7 | CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 44304516 | 164804 | 0 | None | -512 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 357 | 8 | 1 | 5 | 1.5 | O=C1C[C@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL423666 | 164804 | 0 | None | -512 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 357 | 8 | 1 | 5 | 1.5 | O=C1C[C@H](N2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)CC2)N1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304013 | 201205 | 0 | None | -416 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 2.6 | CC(C)(C)[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62716 | 201205 | 0 | None | -416 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 401 | 8 | 1 | 5 | 2.6 | CC(C)(C)[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 164621681 | 184998 | 0 | None | -173 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 444 | 7 | 4 | 5 | 3.2 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4863523 | 184998 | 0 | None | -173 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 444 | 7 | 4 | 5 | 3.2 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 11230971 | 122549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 268 | 0 | 1 | 4 | 2.0 | Cn1ccc2c1CCn1ccnc1C2=C1CCNCC1 | 10.1021/jm049495j | ||
| CHEMBL360953 | 122549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 268 | 0 | 1 | 4 | 2.0 | Cn1ccc2c1CCn1ccnc1C2=C1CCNCC1 | 10.1021/jm049495j | ||
| 135446209 | 9494 | 53 | None | -2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 298 | 0 | 2 | 5 | 3.1 | Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1 | 10.1016/S0960-894X(96)00567-7 | ||
| CHEMBL1125 | 9494 | 53 | None | -2 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 298 | 0 | 2 | 5 | 3.1 | Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1 | 10.1016/S0960-894X(96)00567-7 | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.ejmech.2014.01.012 | ||
| 90469115 | 185260 | 2 | None | -72 | 17 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 410 | 3 | 1 | 6 | 3.0 | O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 | 10.1021/acs.jmedchem.1c00224 | ||
| CHEMBL4867565 | 185260 | 2 | None | -72 | 17 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 410 | 3 | 1 | 6 | 3.0 | O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21 | 10.1021/acs.jmedchem.1c00224 | ||
| 10575070 | 67539 | 0 | None | 79 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 4.7 | O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910383 | 67539 | 0 | None | 79 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 439 | 7 | 1 | 3 | 4.7 | O=C(c1cc2ccccc2[nH]1)N1CCN(CCOC(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.001 | ||
| 44304387 | 201239 | 0 | None | -446 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 334 | 7 | 0 | 5 | 2.4 | CCOC(=O)N1CCN(CCCOc2ccc(C(C)=O)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62840 | 201239 | 0 | None | -446 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 334 | 7 | 0 | 5 | 2.4 | CCOC(=O)N1CCN(CCCOc2ccc(C(C)=O)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304244 | 201486 | 0 | None | -141 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 372 | 12 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(CC3CC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64253 | 201486 | 0 | None | -141 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 372 | 12 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(CC3CC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 90654503 | 109823 | 0 | None | -29 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 483 | 9 | 1 | 4 | 4.9 | O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.ejmech.2014.03.014 | ||
| CHEMBL3238447 | 109823 | 0 | None | -29 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 483 | 9 | 1 | 4 | 4.9 | O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.ejmech.2014.03.014 | ||
| 44304741 | 201228 | 0 | None | -223 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 466 | 13 | 1 | 6 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)Cc3ccncc3)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62808 | 201228 | 0 | None | -223 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 466 | 13 | 1 | 6 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)Cc3ccncc3)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 57402933 | 68684 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 260 | 4 | 2 | 3 | 2.1 | CNCC(O)CN1c2ccccc2C2CCCCC21 | 10.1021/jm2011589 | ||
| CHEMBL1923528 | 68684 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 260 | 4 | 2 | 3 | 2.1 | CNCC(O)CN1c2ccccc2C2CCCCC21 | 10.1021/jm2011589 | ||
| 155537890 | 171775 | 0 | None | 8 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 302 | 5 | 0 | 3 | 2.6 | CN1CCc2ccc(OCCCN3CCCCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4475658 | 171775 | 0 | None | 8 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 302 | 5 | 0 | 3 | 2.6 | CN1CCc2ccc(OCCCN3CCCCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 11154555 | 788 | 57 | None | -56 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| 5037 | 788 | 57 | None | -56 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| 7671 | 788 | 57 | None | -56 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL2028019 | 788 | 57 | None | -56 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL3085826 | 788 | 57 | None | -56 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| DB06016 | 788 | 57 | None | -56 | 12 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| 44267053 | 6384 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 428 | 1 | 0 | 2 | 5.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(-c4ccccc4)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL10826 | 6384 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 428 | 1 | 0 | 2 | 5.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(-c4ccccc4)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 44267061 | 97776 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 366 | 0 | 0 | 2 | 4.6 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C)ccnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL274357 | 97776 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 366 | 0 | 0 | 2 | 4.6 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(C)ccnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 44334212 | 4561 | 0 | None | -501 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 456 | 11 | 1 | 5 | 3.7 | CCc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL102925 | 4561 | 0 | None | -501 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 456 | 11 | 1 | 5 | 3.7 | CCc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44334369 | 4945 | 0 | None | -436 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 484 | 10 | 1 | 5 | 4.4 | CC(C)(C)c1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL105071 | 4945 | 0 | None | -436 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 484 | 10 | 1 | 5 | 4.4 | CC(C)(C)c1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44275807 | 98513 | 0 | None | -2137 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 4.5 | C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1 | 10.1016/s0960-894x(03)00118-5 | ||
| CHEMBL27979 | 98513 | 0 | None | -2137 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 4.5 | C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1 | 10.1016/s0960-894x(03)00118-5 | ||
| 164608815 | 183872 | 0 | None | -58 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 380 | 7 | 4 | 4 | 2.8 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4846638 | 183872 | 0 | None | -58 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 380 | 7 | 4 | 4 | 2.8 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1016/j.ejmech.2021.113190 | ||
| 53359025 | 62024 | 0 | None | -25 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 339 | 5 | 1 | 3 | 2.5 | O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1 | 10.1016/j.bmcl.2012.08.046 | ||
| CHEMBL1779058 | 62024 | 0 | None | -25 | 5 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 339 | 5 | 1 | 3 | 2.5 | O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1 | 10.1016/j.bmcl.2012.08.046 | ||
| 53324553 | 56560 | 0 | None | -3 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 283 | 4 | 1 | 1 | 3.1 | Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1 | 10.1016/j.bmcl.2010.11.075 | ||
| CHEMBL1643900 | 56560 | 0 | None | -3 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 283 | 4 | 1 | 1 | 3.1 | Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1 | 10.1016/j.bmcl.2010.11.075 | ||
| 53324553 | 56560 | 0 | None | -3 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 283 | 4 | 1 | 1 | 3.1 | Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1 | 10.1016/j.bmc.2013.07.045 | ||
| CHEMBL1643900 | 56560 | 0 | None | -3 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 283 | 4 | 1 | 1 | 3.1 | Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1 | 10.1016/j.bmc.2013.07.045 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.1c00692 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.ejmech.2021.113190 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.ejmech.2021.113190 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.ejmech.2021.113190 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.ejmech.2021.113190 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1016/j.ejmech.2021.113190 | ||
| 168269877 | 189434 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 783 | 22 | 6 | 8 | 3.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5171683 | 189434 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 783 | 22 | 6 | 8 | 3.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 164622259 | 185148 | 0 | None | -2290 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 336 | 6 | 4 | 5 | 1.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4865965 | 185148 | 0 | None | -2290 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 336 | 6 | 4 | 5 | 1.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccco1 | 10.1016/j.ejmech.2021.113190 | ||
| 168269877 | 189434 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 783 | 22 | 6 | 8 | 3.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5171683 | 189434 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 783 | 22 | 6 | 8 | 3.0 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 15749417 | 101627 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1/c2ccccc2COc2cc(C(=O)O)ccc21 | 10.1021/jm00089a020 | ||
| CHEMBL302215 | 101627 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1/c2ccccc2COc2cc(C(=O)O)ccc21 | 10.1021/jm00089a020 | ||
| 53321494 | 57444 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 311 | 7 | 0 | 3 | 3.3 | CN(CCF)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669407 | 57444 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 311 | 7 | 0 | 3 | 3.3 | CN(CCF)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 53318874 | 57464 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 7 | 0 | 5 | 3.9 | C[C@H](C1=C(CCN(C)Cc2cnccn2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669426 | 57464 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 7 | 0 | 5 | 3.9 | C[C@H](C1=C(CCN(C)Cc2cnccn2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 18715382 | 8867 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(Cl)ccnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL10981 | 8867 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3c(Cl)ccnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 46216770 | 197589 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 313 | 5 | 1 | 1 | 4.6 | c1ccc(CCNCC2c3ccccc3Cc3ccccc32)cc1 | 10.1016/j.bmcl.2009.12.064 | ||
| CHEMBL590241 | 197589 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 313 | 5 | 1 | 1 | 4.6 | c1ccc(CCNCC2c3ccccc3Cc3ccccc32)cc1 | 10.1016/j.bmcl.2009.12.064 | ||
| 10066369 | 119752 | 0 | None | -8 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 348 | 7 | 0 | 2 | 5.7 | CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL352375 | 119752 | 0 | None | -8 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 348 | 7 | 0 | 2 | 5.7 | CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 164614841 | 184692 | 0 | None | -691 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 388 | 7 | 4 | 4 | 3.0 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4858849 | 184692 | 0 | None | -691 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 388 | 7 | 4 | 4 | 3.0 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(C)C | 10.1016/j.ejmech.2021.113190 | ||
| 164628701 | 185885 | 0 | None | -144 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 338 | 5 | 4 | 4 | 1.9 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4876743 | 185885 | 0 | None | -144 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 338 | 5 | 4 | 4 | 1.9 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC1CCCCC1 | 10.1016/j.ejmech.2021.113190 | ||
| 72152558 | 161854 | 5 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 331 | 5 | 1 | 5 | 2.7 | Cc1cccc(N2CCN(CCNc3cncc(Cl)n3)CC2)c1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4165881 | 161854 | 5 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 331 | 5 | 1 | 5 | 2.7 | Cc1cccc(N2CCN(CCNc3cncc(Cl)n3)CC2)c1 | 10.1021/acs.jmedchem.8b00718 | ||
| 657255 | 197406 | 29 | None | -18 | 15 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 337 | 12 | 2 | 3 | 5.6 | CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 | nan | ||
| CHEMBL588119 | 197406 | 29 | None | -18 | 15 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 337 | 12 | 2 | 3 | 5.6 | CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 | nan | ||
| 53317595 | 57454 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 341 | 5 | 0 | 3 | 3.8 | FC1(F)CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669416 | 57454 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 341 | 5 | 0 | 3 | 3.8 | FC1(F)CCN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 60785 | 204177 | 42 | None | -204 | 7 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 425 | 5 | 0 | 4 | 3.7 | O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm00112a025 | ||
| CHEMBL83894 | 204177 | 42 | None | -204 | 7 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 425 | 5 | 0 | 4 | 3.7 | O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm00112a025 | ||
| 14248602 | 54157 | 0 | None | 21 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 237 | 2 | 0 | 1 | 3.3 | CN(C)CC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL160933 | 54157 | 0 | None | 21 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 237 | 2 | 0 | 1 | 3.3 | CN(C)CC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113931 | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113931 | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113931 | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113931 | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.ejmech.2021.113931 | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2016.05.053 | ||
| 71072115 | 80846 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158770 | 80846 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 515 | 8 | 1 | 5 | 5.1 | N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69348078 | 80879 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158820 | 80879 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59296048 | 83602 | 0 | None | -6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 582 | 9 | 4 | 7 | 2.4 | CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207284 | 83602 | 0 | None | -6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 582 | 9 | 4 | 7 | 2.4 | CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295914 | 83670 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 638 | 9 | 4 | 8 | 2.2 | CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207655 | 83670 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 638 | 9 | 4 | 8 | 2.2 | CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59296100 | 83674 | 0 | None | -7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 460 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207659 | 83674 | 0 | None | -7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 460 | 7 | 3 | 5 | 3.0 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 44396220 | 124903 | 1 | None | 1 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL364565 | 124903 | 1 | None | 1 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 134145957 | 153974 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 296 | 4 | 0 | 1 | 3.9 | C[N+]1(C)CCC(Oc2ccccc2Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3944629 | 153974 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 296 | 4 | 0 | 1 | 3.9 | C[N+]1(C)CCC(Oc2ccccc2Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3990701 | 153974 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 296 | 4 | 0 | 1 | 3.9 | C[N+]1(C)CCC(Oc2ccccc2Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| 23102749 | 81822 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.3 | Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171016 | 81822 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.3 | Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 22397445 | 81827 | 0 | None | -2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 499 | 4 | 1 | 4 | 5.0 | O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171020 | 81827 | 0 | None | -2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 499 | 4 | 1 | 4 | 5.0 | O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 69826668 | 81828 | 0 | None | -5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 5 | 0 | 5 | 4.9 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171021 | 81828 | 0 | None | -5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 5 | 0 | 5 | 4.9 | Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 71449857 | 81830 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171023 | 81830 | 0 | None | 10 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 4.8 | O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71453505 | 81848 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171041 | 81848 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 554 | 6 | 1 | 6 | 4.5 | CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963226 | 81855 | 0 | None | -3 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 505 | 5 | 1 | 5 | 4.4 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171048 | 81855 | 0 | None | -3 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 505 | 5 | 1 | 5 | 4.4 | Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.124 | ||
| 44343573 | 110568 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 369 | 2 | 0 | 3 | 3.5 | CCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL326289 | 110568 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 369 | 2 | 0 | 3 | 3.5 | CCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 44334406 | 4794 | 0 | None | -660 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 462 | 10 | 1 | 5 | 3.8 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL104344 | 4794 | 0 | None | -660 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 462 | 10 | 1 | 5 | 3.8 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 10472143 | 118772 | 0 | None | -5623 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
| CHEMBL343755 | 118772 | 0 | None | -5623 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
| 59295960 | 83683 | 0 | None | -12 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 532 | 8 | 4 | 6 | 2.6 | NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207667 | 83683 | 0 | None | -12 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 532 | 8 | 4 | 6 | 2.6 | NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 59296041 | 83686 | 0 | None | -3 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 558 | 8 | 3 | 8 | 2.1 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207670 | 83686 | 0 | None | -3 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 558 | 8 | 3 | 8 | 2.1 | CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 | 10.1016/j.bmcl.2012.09.112 | ||
| 18722998 | 153937 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 191 | 2 | 0 | 2 | 2.2 | CN1CCC(Oc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3983211 | 153937 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 191 | 2 | 0 | 2 | 2.2 | CN1CCC(Oc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3990343 | 153937 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 191 | 2 | 0 | 2 | 2.2 | CN1CCC(Oc2ccccc2)CC1 | 10.1021/acs.jmedchem.6b00981 | ||
| 46881468 | 6781 | 0 | None | -10 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 245 | 3 | 1 | 3 | 1.9 | c1ccc(N2CCN(CC3CCCCN3)C2)cc1 | 10.1016/j.bmcl.2010.01.090 | ||
| CHEMBL1084132 | 6781 | 0 | None | -10 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 245 | 3 | 1 | 3 | 1.9 | c1ccc(N2CCN(CC3CCCCN3)C2)cc1 | 10.1016/j.bmcl.2010.01.090 | ||
| 10420190 | 205033 | 0 | None | -2 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 195 | 8 | 2 | 2 | 2.3 | NCCCCCCCCc1c[nH]cn1 | 10.1021/jm00002a008 | ||
| CHEMBL90063 | 205033 | 0 | None | -2 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 195 | 8 | 2 | 2 | 2.3 | NCCCCCCCCc1c[nH]cn1 | 10.1021/jm00002a008 | ||
| 11533362 | 80220 | 0 | None | -7943 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 497 | 6 | 0 | 6 | 3.4 | CS(=O)(=O)c1ccc(C(=O)N2CCN(c3ccc(OC4CCN(C5CCC5)CC4)cc3)CC2)cc1 | 10.1021/jm100064d | ||
| CHEMBL2151155 | 80220 | 0 | None | -7943 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 497 | 6 | 0 | 6 | 3.4 | CS(=O)(=O)c1ccc(C(=O)N2CCN(c3ccc(OC4CCN(C5CCC5)CC4)cc3)CC2)cc1 | 10.1021/jm100064d | ||
| 9976892 | 103477 | 32 | None | -10715 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 377 | 4 | 0 | 4 | 4.0 | O=C1CCCN1c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1 | 10.1016/j.bmcl.2013.09.090 | ||
| CHEMBL3092650 | 103477 | 32 | None | -10715 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 377 | 4 | 0 | 4 | 4.0 | O=C1CCCN1c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1 | 10.1016/j.bmcl.2013.09.090 | ||
| 168292954 | 192395 | 0 | None | -44 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.5 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5202592 | 192395 | 0 | None | -44 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.5 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222660 | 192395 | 0 | None | -44 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.5 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 10039772 | 103882 | 0 | None | -100 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 288 | 7 | 3 | 2 | 3.1 | S=C(NCCCCCc1c[nH]cn1)Nc1ccccc1 | 10.1021/jm00012a025 | ||
| CHEMBL310087 | 103882 | 0 | None | -100 | 3 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 288 | 7 | 3 | 2 | 3.1 | S=C(NCCCCCc1c[nH]cn1)Nc1ccccc1 | 10.1021/jm00012a025 | ||
| 112936341 | 136949 | 1 | None | 12 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 359 | 5 | 1 | 5 | 3.5 | CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753849 | 136949 | 1 | None | 12 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 359 | 5 | 1 | 5 | 3.5 | CN1CCN(c2nc(NCc3ccccc3)cc(-c3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 10711079 | 98287 | 0 | None | -1318 | 2 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 323 | 5 | 2 | 3 | 3.4 | O=C(Nc1ccc(Br)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL277989 | 98287 | 0 | None | -1318 | 2 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 323 | 5 | 2 | 3 | 3.4 | O=C(Nc1ccc(Br)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 155515780 | 169457 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 318 | 6 | 0 | 4 | 1.8 | CCN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4442619 | 169457 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 318 | 6 | 0 | 4 | 1.8 | CCN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 9947477 | 198285 | 0 | None | -25 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 368 | 10 | 2 | 3 | 4.6 | Clc1ccc(C(CCNCCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL59512 | 198285 | 0 | None | -25 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 368 | 10 | 2 | 3 | 4.6 | Clc1ccc(C(CCNCCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00357-3 | ||
| 95214051 | 161873 | 0 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 331 | 6 | 2 | 5 | 1.7 | O=C(CO)NC[C@H]1CCN(Cc2csc(-c3ccccc3)n2)C1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4166178 | 161873 | 0 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 331 | 6 | 2 | 5 | 1.7 | O=C(CO)NC[C@H]1CCN(Cc2csc(-c3ccccc3)n2)C1 | 10.1021/acs.jmedchem.8b00718 | ||
| 44478385 | 5699 | 2 | None | -446 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 342 | 9 | 3 | 4 | 2.5 | N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1 | 10.1021/jm900526h | ||
| CHEMBL1078642 | 5699 | 2 | None | -446 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 342 | 9 | 3 | 4 | 2.5 | N#C/N=C(/NCCCCc1c[nH]cn1)NCCSc1ccccc1 | 10.1021/jm900526h | ||
| 164611474 | 184870 | 0 | None | -407 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 366 | 6 | 4 | 5 | 2.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4861704 | 184870 | 0 | None | -407 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 366 | 6 | 4 | 5 | 2.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccs1 | 10.1016/j.ejmech.2021.113190 | ||
| 9906978 | 42466 | 1 | None | -28 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL150161 | 42466 | 1 | None | -28 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 9906978 | 42466 | 1 | None | -28 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
| CHEMBL150161 | 42466 | 1 | None | -28 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
| 9850828 | 169335 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 562 | 11 | 2 | 5 | 5.0 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL444083 | 169335 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 562 | 11 | 2 | 5 | 5.0 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 155547818 | 172996 | 0 | None | 2 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 302 | 5 | 0 | 3 | 2.6 | CC1CCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4532574 | 172996 | 0 | None | 2 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 302 | 5 | 0 | 3 | 2.6 | CC1CCCN1CCCOc1ccc2c(c1)C(=O)N(C)CC2 | 10.1016/j.bmcl.2019.04.015 | ||
| 44449794 | 157717 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 3.5 | COc1cc(Cl)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1 | 10.1016/j.bmcl.2008.03.050 | ||
| CHEMBL408868 | 157717 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 3.5 | COc1cc(Cl)ccc1O[C@H](c1ccccc1)[C@H]1CNCCO1 | 10.1016/j.bmcl.2008.03.050 | ||
| 11848679 | 88814 | 0 | None | -204 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 489 | 9 | 3 | 9 | 2.9 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL236788 | 88814 | 0 | None | -204 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 489 | 9 | 3 | 9 | 2.9 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N | 10.1016/j.bmcl.2009.09.024 | ||
| 146025727 | 171119 | 0 | None | -97 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| CHEMBL4466483 | 171119 | 0 | None | -97 | 27 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| 71456046 | 83661 | 0 | None | -1737 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 4.2 | COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| CHEMBL2207637 | 83661 | 0 | None | -1737 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 389 | 6 | 0 | 4 | 4.2 | COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| 44209472 | 69829 | 2 | None | -144 | 11 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL1940420 | 69829 | 2 | None | -144 | 11 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| 1072350 | 68685 | 5 | None | -4 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 269 | 3 | 0 | 5 | 2.2 | c1ccc2c(c1)nc1n(CCN3CCCCC3)cnn21 | 10.1021/jm2011589 | ||
| CHEMBL1923529 | 68685 | 5 | None | -4 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 269 | 3 | 0 | 5 | 2.2 | c1ccc2c(c1)nc1n(CCN3CCCCC3)cnn21 | 10.1021/jm2011589 | ||
| 44304978 | 167326 | 0 | None | -1230 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 396 | 11 | 0 | 5 | 2.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(S(C)(=O)=O)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL431172 | 167326 | 0 | None | -1230 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 396 | 11 | 0 | 5 | 2.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(S(C)(=O)=O)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 46230651 | 198824 | 0 | None | -125 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 289 | 2 | 1 | 2 | 3.8 | COc1ccc2c3c(ccc2c1)Cc1ccccc1C3CN | 10.1016/j.bmcl.2009.12.064 | ||
| CHEMBL598753 | 198824 | 0 | None | -125 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 289 | 2 | 1 | 2 | 3.8 | COc1ccc2c3c(ccc2c1)Cc1ccccc1C3CN | 10.1016/j.bmcl.2009.12.064 | ||
| 164585622 | 184345 | 0 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 506 | 6 | 2 | 7 | 5.5 | O=C(O)c1cc(-c2ccc(-c3cc(CO)on3)cc2)cc(-n2cc(-c3ccc(C(F)(F)F)cc3)nn2)c1 | 10.1021/acs.jmedchem.1c00164 | ||
| CHEMBL4853466 | 184345 | 0 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 506 | 6 | 2 | 7 | 5.5 | O=C(O)c1cc(-c2ccc(-c3cc(CO)on3)cc2)cc(-n2cc(-c3ccc(C(F)(F)F)cc3)nn2)c1 | 10.1021/acs.jmedchem.1c00164 | ||
| 24740863 | 88728 | 0 | None | -3 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 6 | 1 | 5 | 5.0 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL236610 | 88728 | 0 | None | -3 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 385 | 6 | 1 | 5 | 5.0 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl | 10.1016/j.bmcl.2009.09.024 | ||
| 56781741 | 162085 | 5 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 337 | 6 | 0 | 6 | 3.0 | Cc1cc(C)n(C2CN(CCCc3nc(-c4ccccc4)no3)C2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4169603 | 162085 | 5 | None | 1 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 337 | 6 | 0 | 6 | 3.0 | Cc1cc(C)n(C2CN(CCCc3nc(-c4ccccc4)no3)C2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| 168291233 | 192377 | 0 | None | -6 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 373 | 8 | 4 | 5 | 1.4 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5200106 | 192377 | 0 | None | -6 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 373 | 8 | 4 | 5 | 1.4 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222556 | 192377 | 0 | None | -6 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 373 | 8 | 4 | 5 | 1.4 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2nnc(N)o2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44326298 | 206172 | 0 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)CC1C[C@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL96732 | 206172 | 0 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)CC1C[C@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.07.047 | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.07.047 | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.07.047 | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.07.047 | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 10.1016/j.bmcl.2009.07.047 | ||
| 44335237 | 5052 | 0 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 7 | 0 | 5 | 4.1 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3C)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105669 | 5052 | 0 | None | 3 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 7 | 0 | 5 | 4.1 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(C#N)cc3C)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 11963995 | 91433 | 0 | None | -15 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 387 | 6 | 1 | 4 | 3.8 | CCOc1cc(CN2CCC(NC(=O)c3cncc(C)c3)CC2)ccc1Cl | 10.1021/jm701144e | ||
| CHEMBL241329 | 91433 | 0 | None | -15 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 387 | 6 | 1 | 4 | 3.8 | CCOc1cc(CN2CCC(NC(=O)c3cncc(C)c3)CC2)ccc1Cl | 10.1021/jm701144e | ||
| 49783209 | 17427 | 0 | None | -4786 | 27 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258223 | 17427 | 0 | None | -4786 | 27 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 409544 | 201225 | 3 | None | -194 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 11 | 0 | 5 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62803 | 201225 | 3 | None | -194 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 390 | 11 | 0 | 5 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304383 | 201612 | 0 | None | -27 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 418 | 12 | 0 | 5 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64775 | 201612 | 0 | None | -27 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 418 | 12 | 0 | 5 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335559 | 109221 | 0 | None | -162 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.7 | CC1CCCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL322873 | 109221 | 0 | None | -162 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.7 | CC1CCCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1 | 10.1016/s0960-894x(02)00648-0 | ||
| 79698 | 200506 | 87 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 211 | 4 | 1 | 1 | 3.2 | NCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL609579 | 200506 | 87 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 211 | 4 | 1 | 1 | 3.2 | NCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 25450664 | 161447 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 392 | 6 | 0 | 6 | 3.9 | COC(=O)c1ccc(-c2nc(CN(C)C[C@@H]3Cc4ccccc4O3)c(C)o2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4159365 | 161447 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 392 | 6 | 0 | 6 | 3.9 | COC(=O)c1ccc(-c2nc(CN(C)C[C@@H]3Cc4ccccc4O3)c(C)o2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| 53322839 | 57461 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 373 | 7 | 0 | 5 | 3.8 | C[C@H](C1=C(CCN(C)Cc2nccn2C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669423 | 57461 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 373 | 7 | 0 | 5 | 3.8 | C[C@H](C1=C(CCN(C)Cc2nccn2C)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 11808040 | 167831 | 0 | None | -2 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.8 | CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL434684 | 167831 | 0 | None | -2 | 6 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 278 | 4 | 0 | 2 | 3.8 | CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 46929647 | 16579 | 0 | None | -19 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 355 | 5 | 2 | 3 | 4.3 | FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1 | 10.1021/jm100643t | ||
| CHEMBL1243394 | 16579 | 0 | None | -19 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 355 | 5 | 2 | 3 | 4.3 | FC(F)(F)c1ccc(SC[C@H](c2c[nH]cn2)C2CCNCC2)cc1 | 10.1021/jm100643t | ||
| 28357663 | 161595 | 1 | None | 1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 301 | 5 | 0 | 3 | 3.3 | Cc1ccn(CCN2CCC(Cc3ccccc3F)CC2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4161837 | 161595 | 1 | None | 1 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 301 | 5 | 0 | 3 | 3.3 | Cc1ccn(CCN2CCC(Cc3ccccc3F)CC2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| 49841846 | 69395 | 0 | None | -812 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 325 | 2 | 1 | 6 | 2.7 | CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1 | 10.1016/j.bmcl.2011.10.104 | ||
| CHEMBL1935572 | 69395 | 0 | None | -812 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 325 | 2 | 1 | 6 | 2.7 | CN1CCN(c2nc(N)nc3cc(-c4ccsc4)ccc23)CC1 | 10.1016/j.bmcl.2011.10.104 | ||
| 10451094 | 200786 | 0 | None | -56234 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 359 | 9 | 1 | 5 | 1.5 | NCCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL61120 | 200786 | 0 | None | -56234 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 359 | 9 | 1 | 5 | 1.5 | NCCC(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 127038376 | 136260 | 0 | None | -323 | 5 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 6 | 0 | 7 | 4.2 | O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC(CN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1 | 10.1039/C4MD00578C | ||
| CHEMBL3741292 | 136260 | 0 | None | -323 | 5 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 6 | 0 | 7 | 4.2 | O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC(CN3CCC(c4noc5cc(F)ccc45)CC3)CC2)cc1 | 10.1039/C4MD00578C | ||
| 44304751 | 100554 | 0 | None | -7 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 422 | 11 | 0 | 4 | 4.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL294519 | 100554 | 0 | None | -7 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 422 | 11 | 0 | 4 | 4.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335225 | 163603 | 0 | None | -190 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 347 | 6 | 1 | 4 | 3.1 | N#Cc1ccc(-c2ccc(OCCCN3CC4CNCC4C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL421026 | 163603 | 0 | None | -190 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 347 | 6 | 1 | 4 | 3.1 | N#Cc1ccc(-c2ccc(OCCCN3CC4CNCC4C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168294178 | 192433 | 0 | None | -1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 414 | 5 | 4 | 4 | 4.4 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5205197 | 192433 | 0 | None | -1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 414 | 5 | 4 | 4 | 4.4 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222887 | 192433 | 0 | None | -1 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 414 | 5 | 4 | 4 | 4.4 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)C2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 164627241 | 185847 | 0 | None | -95 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 438 | 6 | 4 | 4 | 3.1 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4876267 | 185847 | 0 | None | -95 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 438 | 6 | 4 | 4 | 3.1 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Br)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 164627189 | 185739 | 0 | None | -275 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 298 | 6 | 4 | 4 | 1.0 | CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4874758 | 185739 | 0 | None | -275 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 298 | 6 | 4 | 4 | 1.0 | CCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1016/j.ejmech.2021.113190 | ||
| 118721929 | 115593 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 394 | 2 | 0 | 2 | 5.3 | CC(C)CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357042 | 115593 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 394 | 2 | 0 | 2 | 5.3 | CC(C)CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 162645254 | 179103 | 0 | None | -371 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 7 | 0 | 5 | 4.2 | N#Cc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4743583 | 179103 | 0 | None | -371 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 7 | 0 | 5 | 4.2 | N#Cc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 24841480 | 183317 | 0 | None | -14 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 4.5 | O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 | 10.1016/j.bmcl.2013.04.082 | ||
| CHEMBL481153 | 183317 | 0 | None | -14 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 340 | 3 | 0 | 4 | 4.5 | O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 | 10.1016/j.bmcl.2013.04.082 | ||
| 9928323 | 11832 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 4.1 | CN(C)CC/C=C1/c2ccccc2COc2ccc(/C=C/C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL1182766 | 11832 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 4.1 | CN(C)CC/C=C1/c2ccccc2COc2ccc(/C=C/C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL264979 | 11832 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 4.1 | CN(C)CC/C=C1/c2ccccc2COc2ccc(/C=C/C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 44326433 | 206122 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 3 | 0 | 2 | 6.1 | c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)cc1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL96471 | 206122 | 0 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 3 | 0 | 2 | 6.1 | c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)cc1 | 10.1016/j.bmcl.2004.03.069 | ||
| 23551948 | 109907 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 341 | 2 | 0 | 3 | 2.7 | O=CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL324336 | 109907 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 341 | 2 | 0 | 3 | 2.7 | O=CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 162647537 | 179224 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 294 | 3 | 0 | 2 | 3.0 | CN(C)CCN1C(=O)c2ccccc2CCc2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| CHEMBL4744893 | 179224 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 294 | 3 | 0 | 2 | 3.0 | CN(C)CCN1C(=O)c2ccccc2CCc2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| 14885640 | 16599 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 340 | 3 | 0 | 2 | 4.1 | CC(=O)N(C)CC/C=C1\c2ccc(Cl)cc2CCc2cccnc21 | 10.1021/jm00105a069 | ||
| CHEMBL124466 | 16599 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 340 | 3 | 0 | 2 | 4.1 | CC(=O)N(C)CC/C=C1\c2ccc(Cl)cc2CCc2cccnc21 | 10.1021/jm00105a069 | ||
| 9928224 | 133834 | 0 | None | -1621 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 346 | 6 | 2 | 3 | 3.3 | O=C(CCN1CCC(Cc2c[nH]cn2)CC1)Nc1ccc(Cl)cc1 | 10.1016/j.bmcl.2005.09.076 | ||
| CHEMBL371730 | 133834 | 0 | None | -1621 | 3 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 346 | 6 | 2 | 3 | 3.3 | O=C(CCN1CCC(Cc2c[nH]cn2)CC1)Nc1ccc(Cl)cc1 | 10.1016/j.bmcl.2005.09.076 | ||
| 14885629 | 34754 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 336 | 0 | 0 | 2 | 3.8 | CC(=O)N1CCC(=C2c3cc(F)ccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL143272 | 34754 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 336 | 0 | 0 | 2 | 3.8 | CC(=O)N1CCC(=C2c3cc(F)ccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 162653991 | 179965 | 0 | None | -245 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 470 | 4 | 0 | 3 | 6.0 | C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)CC4(CCCC4)CC3=O)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL4753808 | 179965 | 0 | None | -245 | 5 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 470 | 4 | 0 | 3 | 6.0 | C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)CC4(CCCC4)CC3=O)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| 10347051 | 66825 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 534 | 9 | 2 | 5 | 4.3 | NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL187637 | 66825 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 534 | 9 | 2 | 5 | 4.3 | NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 44591135 | 189584 | 0 | None | -190 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 532 | 10 | 0 | 4 | 8.0 | CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL517407 | 189584 | 0 | None | -190 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 532 | 10 | 0 | 4 | 8.0 | CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 90654501 | 109820 | 0 | None | -31622 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 314 | 6 | 0 | 5 | 3.1 | Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.ejmech.2014.03.014 | ||
| CHEMBL3238444 | 109820 | 0 | None | -31622 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 314 | 6 | 0 | 5 | 3.1 | Cc1nnc(C)n1-c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.ejmech.2014.03.014 | ||
| 132060734 | 162574 | 0 | None | 3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 5 | 0 | 4 | 4.0 | C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4177497 | 162574 | 0 | None | 3 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 391 | 5 | 0 | 4 | 4.0 | C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| 44326427 | 107030 | 0 | None | 144 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 348 | 2 | 0 | 3 | 3.5 | CN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL318659 | 107030 | 0 | None | 144 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 348 | 2 | 0 | 3 | 3.5 | CN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| 2247 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1021/jm0205651 | ||
| 249 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1021/jm0205651 | ||
| 2603 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1021/jm0205651 | ||
| CHEMBL296419 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1021/jm0205651 | ||
| DB00637 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 10.1021/jm0205651 | ||
| 10361564 | 51017 | 0 | None | 1 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 366 | 5 | 0 | 4 | 4.1 | Cn1c(=O)sc2cc(CCN3CCC(Cc4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL15809 | 51017 | 0 | None | 1 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 366 | 5 | 0 | 4 | 4.1 | Cn1c(=O)sc2cc(CCN3CCC(Cc4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 10399921 | 119300 | 0 | None | 4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.7 | CNCCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL348302 | 119300 | 0 | None | 4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.7 | CNCCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 46884731 | 7827 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 323 | 6 | 0 | 4 | 3.6 | COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090175 | 7827 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 323 | 6 | 0 | 4 | 3.6 | COc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| 46884667 | 8203 | 0 | None | 1174 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 0 | 3 | 4.5 | Cc1csc([C@H](C)C2=C(CCN(C)C)Cc3ccccc32)n1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092599 | 8203 | 0 | None | 1174 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 0 | 3 | 4.5 | Cc1csc([C@H](C)C2=C(CCN(C)C)Cc3ccccc32)n1 | 10.1016/j.bmcl.2010.02.055 | ||
| 6075 | 149575 | 36 | None | 2 | 16 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 310 | 2 | 0 | 3 | 4.6 | CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 | nan | ||
| CHEMBL395110 | 149575 | 36 | None | 2 | 16 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 310 | 2 | 0 | 3 | 4.6 | CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 | nan | ||
| 75306277 | 108767 | 0 | None | -1 | 23 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | ||
| CHEMBL3217984 | 108767 | 0 | None | -1 | 23 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | ||
| 71463287 | 83787 | 0 | None | 79 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.1 | N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208419 | 83787 | 0 | None | 79 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.1 | N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 155515934 | 169448 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.7 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ncccn2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4442502 | 169448 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.7 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ncccn2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 89474811 | 172337 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 401 | 2 | 0 | 3 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccn2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4516137 | 172337 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 401 | 2 | 0 | 3 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccn2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 155567448 | 175409 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 350 | 1 | 0 | 2 | 4.9 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4588726 | 175409 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 350 | 1 | 0 | 2 | 4.9 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 4671324 | 13085 | 2 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 269 | 7 | 0 | 2 | 3.6 | CN(C)CCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL1191054 | 13085 | 2 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 269 | 7 | 0 | 2 | 3.6 | CN(C)CCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3955589 | 13085 | 2 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 269 | 7 | 0 | 2 | 3.6 | CN(C)CCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 45268653 | 194056 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 382 | 6 | 1 | 5 | 3.1 | CN(CCO)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL557210 | 194056 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 382 | 6 | 1 | 5 | 3.1 | CN(CCO)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 3191 | 102385 | 93 | None | 2 | 25 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
| CHEMBL305660 | 102385 | 93 | None | 2 | 25 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | nan | ||
| 103 | 4089 | 56 | None | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
| 2875 | 4089 | 56 | None | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
| 5736 | 4089 | 56 | None | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
| CHEMBL285802 | 4089 | 56 | None | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
| DB09225 | 4089 | 56 | None | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm030480f | ||
| 69314950 | 78250 | 0 | None | 4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 279 | 2 | 1 | 2 | 3.4 | CNC[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL2112371 | 78250 | 0 | None | 4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 279 | 2 | 1 | 2 | 3.4 | CNC[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm030480f | ||
| 70941112 | 174818 | 4 | None | 117 | 2 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 2.3 | NC(=O)c1ccc(OCCCN2C[C@H]3CCC[C@H]3C2)cc1 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4575319 | 174818 | 4 | None | 117 | 2 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 2.3 | NC(=O)c1ccc(OCCCN2C[C@H]3CCC[C@H]3C2)cc1 | 10.1016/j.bmcl.2019.04.015 | ||
| 49782791 | 17728 | 0 | None | -8 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 381 | 3 | 1 | 4 | 3.3 | CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| CHEMBL1259173 | 17728 | 0 | None | -8 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 381 | 3 | 1 | 4 | 3.3 | CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| 45271167 | 193694 | 0 | None | 977 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 428 | 6 | 0 | 4 | 5.3 | CN(Cc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL551888 | 193694 | 0 | None | 977 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 428 | 6 | 0 | 4 | 5.3 | CN(Cc1ccccc1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 9850828 | 169335 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 562 | 11 | 2 | 5 | 5.0 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL444083 | 169335 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 562 | 11 | 2 | 5 | 5.0 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 44326407 | 205430 | 0 | None | 23 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 2.8 | OCCN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL92337 | 205430 | 0 | None | 23 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 2.8 | OCCN1CCN(CC2C[C@@H]3c4ccccc4Cc4ccccc4[C@H]3O2)CC1 | 10.1016/j.bmcl.2004.03.069 | ||
| 44326690 | 110984 | 0 | None | 7 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL327651 | 110984 | 0 | None | 7 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 293 | 2 | 0 | 2 | 3.8 | CN(C)C[C@@H]1C[C@H]2c3ccccc3Cc3ccccc3[C@@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 11976 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | ||
| 667467 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL908 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | ||
| DB01239 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | ||
| 135398737 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm400408r | ||
| 38 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm400408r | ||
| 722 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm400408r | ||
| CHEMBL42 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm400408r | ||
| DB00363 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm400408r | ||
| 19861 | 205790 | 45 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 290 | 0 | 0 | 2 | 3.7 | CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL946 | 205790 | 45 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 290 | 0 | 0 | 2 | 3.7 | CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 46884063 | 8057 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 4.7 | C[C@@H](c1ccccn1)c1c(CCN2CCC2)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091775 | 8057 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 322 | 5 | 0 | 3 | 4.7 | C[C@@H](c1ccccn1)c1c(CCN2CCC2)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 44250284 | 193552 | 0 | None | 1230 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 436 | 6 | 0 | 5 | 4.6 | CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL550818 | 193552 | 0 | None | 1230 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 436 | 6 | 0 | 5 | 4.6 | CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 44250284 | 193552 | 0 | None | 1230 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 436 | 6 | 0 | 5 | 4.6 | CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.03.027 | ||
| CHEMBL550818 | 193552 | 0 | None | 1230 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 436 | 6 | 0 | 5 | 4.6 | CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.03.027 | ||
| 9870185 | 83682 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2207666 | 83682 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296104 | 83801 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 503 | 7 | 2 | 5 | 3.8 | CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208433 | 83801 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 503 | 7 | 2 | 5 | 3.8 | CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295994 | 83802 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208434 | 83802 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296090 | 83678 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.3 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207662 | 83678 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.3 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F | 10.1016/j.bmcl.2012.09.112 | ||
| 9870185 | 83682 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207666 | 83682 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 10103 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 133017 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 2413 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL91397 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| DB11614 | 3363 | 66 | None | 25 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 155523802 | 170290 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 400 | 2 | 0 | 2 | 5.9 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4454015 | 170290 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 400 | 2 | 0 | 2 | 5.9 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 155537274 | 171697 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 378 | 1 | 0 | 2 | 5.7 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4474559 | 171697 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 378 | 1 | 0 | 2 | 5.7 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C2CCCC2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 168276508 | 189672 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1140 | 28 | 6 | 11 | 6.9 | C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1 | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5175488 | 189672 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1140 | 28 | 6 | 11 | 6.9 | C[C@@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)NCCNC(=O)CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1 | 10.1021/acs.jmedchem.2c00125 | ||
| 44395497 | 66498 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 560 | 11 | 2 | 5 | 5.4 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL186125 | 66498 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 560 | 11 | 2 | 5 | 5.4 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 9998826 | 119971 | 0 | None | -69 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.1 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1 | 10.1021/jm950759z | ||
| CHEMBL354210 | 119971 | 0 | None | -69 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.1 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1 | 10.1021/jm950759z | ||
| 72152556 | 162388 | 5 | None | -2 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 335 | 5 | 1 | 5 | 2.5 | Fc1ccc(N2CCN(CCNc3cncc(Cl)n3)CC2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4174330 | 162388 | 5 | None | -2 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 335 | 5 | 1 | 5 | 2.5 | Fc1ccc(N2CCN(CCNc3cncc(Cl)n3)CC2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| 44288769 | 100679 | 0 | None | -275 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 542 | 7 | 1 | 4 | 4.5 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL295395 | 100679 | 0 | None | -275 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 542 | 7 | 1 | 4 | 4.5 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| 9958732 | 165438 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 532 | 9 | 2 | 5 | 4.6 | NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL425358 | 165438 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 532 | 9 | 2 | 5 | 4.6 | NC(=O)N(O)CCC#Cc1ccc(OCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 127052294 | 139772 | 0 | None | -15 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3806079 | 139772 | 0 | None | -15 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 168290397 | 191374 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5201087 | 191374 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| 44304385 | 201488 | 0 | None | -61 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 404 | 11 | 0 | 5 | 4.4 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64259 | 201488 | 0 | None | -61 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 404 | 11 | 0 | 5 | 4.4 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 168281536 | 192279 | 0 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 12 | 4 | 5 | 1.7 | Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5189006 | 192279 | 0 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 12 | 4 | 5 | 1.7 | Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221966 | 192279 | 0 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 369 | 12 | 4 | 5 | 1.7 | Cc1nnc(CCCN/C(N)=N/C(=O)NCCCCCCCCN)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168290397 | 191374 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5201087 | 191374 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| 11753159 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 7679 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158814 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 68938028 | 80848 | 0 | None | -6 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158772 | 80848 | 0 | None | -6 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 12001832 | 80860 | 0 | None | -63 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158784 | 80860 | 0 | None | -63 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 66615627 | 80866 | 0 | None | -158 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 536 | 8 | 1 | 4 | 6.1 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158790 | 80866 | 0 | None | -158 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 536 | 8 | 1 | 4 | 6.1 | Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 71460419 | 80898 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158838 | 80898 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59295939 | 83798 | 0 | None | -12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 461 | 7 | 3 | 4 | 4.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208430 | 83798 | 0 | None | -12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 461 | 7 | 3 | 4 | 4.1 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 12660330 | 154053 | 3 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 255 | 7 | 1 | 2 | 3.3 | CNCCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3964404 | 154053 | 3 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 255 | 7 | 1 | 2 | 3.3 | CNCCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3991396 | 154053 | 3 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 255 | 7 | 1 | 2 | 3.3 | CNCCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 9888211 | 21216 | 9 | None | -39 | 10 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 4.5 | O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 | 10.1021/jm070516u | ||
| CHEMBL131495 | 21216 | 9 | None | -39 | 10 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 4.5 | O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 | 10.1021/jm070516u | ||
| 11753159 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 7679 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2158814 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2012.08.124 | ||
| 71462390 | 81833 | 0 | None | 6 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 500 | 5 | 1 | 6 | 4.3 | O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171026 | 81833 | 0 | None | 6 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 500 | 5 | 1 | 6 | 4.3 | O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963315 | 81840 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 511 | 5 | 1 | 5 | 4.4 | O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171033 | 81840 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 511 | 5 | 1 | 5 | 4.4 | O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71455217 | 81849 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171042 | 81849 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 95338888 | 161976 | 1 | None | 1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 286 | 5 | 0 | 3 | 4.1 | CCCc1nc(CN2CC[C@H](c3ccccc3)C2)cs1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4167807 | 161976 | 1 | None | 1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 286 | 5 | 0 | 3 | 4.1 | CCCc1nc(CN2CC[C@H](c3ccccc3)C2)cs1 | 10.1021/acs.jmedchem.8b00718 | ||
| 14554145 | 30674 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3cc(Cl)c(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL139760 | 30674 | 0 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 386 | 0 | 0 | 2 | 4.9 | CC(=O)N1CCC(=C2c3cc(Cl)c(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 9549064 | 97561 | 3 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.9 | CCCc1ccc2c(c1)sc(=O)n2CCN1CCCCCC1 | 10.1007/s00044-005-0131-1 | ||
| CHEMBL272899 | 97561 | 3 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 318 | 5 | 0 | 4 | 3.9 | CCCc1ccc2c(c1)sc(=O)n2CCN1CCCCCC1 | 10.1007/s00044-005-0131-1 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm501086v | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm501086v | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm501086v | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm501086v | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm501086v | ||
| 162669496 | 182013 | 0 | None | -45 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 466 | 4 | 0 | 3 | 5.1 | C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5C=C[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL4788140 | 182013 | 0 | None | -45 | 4 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 466 | 4 | 0 | 3 | 5.1 | C[C@H]1CN(CC[C@H]2CC[C@H](N3C(=O)[C@H]4[C@H]5C=C[C@H](C5)[C@H]4C3=O)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| 122196381 | 123776 | 0 | None | -295 | 5 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 485 | 8 | 0 | 6 | 6.3 | Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1 | 10.1016/j.bmcl.2015.09.045 | ||
| CHEMBL3634821 | 123776 | 0 | None | -295 | 5 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 485 | 8 | 0 | 6 | 6.3 | Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1 | 10.1016/j.bmcl.2015.09.045 | ||
| 71454365 | 83786 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 4.6 | O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208418 | 83786 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 465 | 8 | 2 | 6 | 4.6 | O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 17178058 | 145954 | 25 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 253 | 3 | 1 | 2 | 3.5 | c1ccc(-c2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3922367 | 145954 | 25 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 253 | 3 | 1 | 2 | 3.5 | c1ccc(-c2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 20252868 | 153945 | 1 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 241 | 6 | 1 | 2 | 3.0 | NCCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3981091 | 153945 | 1 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 241 | 6 | 1 | 2 | 3.0 | NCCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3990430 | 153945 | 1 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 241 | 6 | 1 | 2 | 3.0 | NCCCOc1ccccc1Cc1ccccc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 44270793 | 51068 | 0 | None | -30 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 328 | 6 | 2 | 4 | 2.9 | O=C(NN1CCC(c2ccccc2)CC1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL15813 | 51068 | 0 | None | -30 | 2 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 328 | 6 | 2 | 4 | 2.9 | O=C(NN1CCC(c2ccccc2)CC1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 155536080 | 171548 | 0 | None | -21 | 10 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.9 | CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | ||
| CHEMBL4472703 | 171548 | 0 | None | -21 | 10 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 219 | 2 | 1 | 2 | 2.9 | CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N | 10.1021/acsmedchemlett.9b00225 | ||
| 11723317 | 102421 | 0 | None | -100 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 316 | 9 | 3 | 2 | 2.8 | S=C(NCCCCCc1c[nH]cn1)NCCc1ccccc1 | 10.1021/jm00012a025 | ||
| CHEMBL305929 | 102421 | 0 | None | -100 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 316 | 9 | 3 | 2 | 2.8 | S=C(NCCCCCc1c[nH]cn1)NCCc1ccccc1 | 10.1021/jm00012a025 | ||
| 10015196 | 103145 | 0 | None | -158 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 254 | 8 | 3 | 2 | 2.4 | CCC/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| CHEMBL308717 | 103145 | 0 | None | -158 | 3 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 254 | 8 | 3 | 2 | 2.4 | CCC/N=C(\S)NCCCCCc1c[nH]cn1 | 10.1021/jm00012a025 | ||
| 10803416 | 54330 | 0 | None | -1023 | 2 | Guinea pig | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 290 | 6 | 2 | 5 | 2.5 | O=C(Nc1ccccc1[N+](=O)[O-])OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16109 | 54330 | 0 | None | -1023 | 2 | Guinea pig | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 290 | 6 | 2 | 5 | 2.5 | O=C(Nc1ccccc1[N+](=O)[O-])OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 90654502 | 109822 | 0 | None | -741 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 319 | 9 | 2 | 4 | 1.9 | C[C@H](NCc1ccc(OCCCN2CCCCC2)cc1)C(N)=O | 10.1016/j.ejmech.2014.03.014 | ||
| CHEMBL3238446 | 109822 | 0 | None | -741 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 319 | 9 | 2 | 4 | 1.9 | C[C@H](NCc1ccc(OCCCN2CCCCC2)cc1)C(N)=O | 10.1016/j.ejmech.2014.03.014 | ||
| 53317594 | 57446 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 6 | 0 | 4 | 3.4 | C[C@H](C1=C(CCN(C)CC#N)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669409 | 57446 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 6 | 0 | 4 | 3.4 | C[C@H](C1=C(CCN(C)CC#N)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 155544150 | 172762 | 0 | None | 8 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 2.8 | CC1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4526723 | 172762 | 0 | None | 8 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 2.8 | CC1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1 | 10.1016/j.bmcl.2019.04.015 | ||
| 72152555 | 162180 | 5 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 345 | 7 | 1 | 5 | 3.1 | Clc1cncc(NCCCCN2CCN(c3ccccc3)CC2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4171171 | 162180 | 5 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 345 | 7 | 1 | 5 | 3.1 | Clc1cncc(NCCCCN2CCN(c3ccccc3)CC2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| 44326320 | 112321 | 0 | None | 2 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 2 | 0 | 3 | 4.0 | CN(C)CC1C[C@H]2c3ccccc3Oc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL330713 | 112321 | 0 | None | 2 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 2 | 0 | 3 | 4.0 | CN(C)CC1C[C@H]2c3ccccc3Oc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 1853 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1016/S0960-894X(00)80290-5 | ||
| 60680 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL10971 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1016/S0960-894X(00)80290-5 | ||
| 1853 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1016/s0960-894x(98)00626-x | ||
| 60680 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL10971 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1016/s0960-894x(98)00626-x | ||
| 1853 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1021/jm00105a069 | ||
| 60680 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1021/jm00105a069 | ||
| CHEMBL10971 | 3495 | 27 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 352 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 | 10.1021/jm00105a069 | ||
| 45485498 | 195994 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 231 | 5 | 0 | 1 | 3.8 | Cc1ccc(CCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL571073 | 195994 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 231 | 5 | 0 | 1 | 3.8 | Cc1ccc(CCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 46884062 | 8274 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 296 | 5 | 1 | 3 | 4.2 | CNCCc1sc2ccccc2c1[C@@H](C)c1ccccn1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1093044 | 8274 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 296 | 5 | 1 | 3 | 4.2 | CNCCc1sc2ccccc2c1[C@@H](C)c1ccccn1 | 10.1016/j.bmcl.2010.01.134 | ||
| 95339542 | 161481 | 1 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 286 | 4 | 0 | 3 | 4.3 | CC(C)c1nc(CN2CC[C@H](c3ccccc3)C2)cs1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4159893 | 161481 | 1 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 286 | 4 | 0 | 3 | 4.3 | CC(C)c1nc(CN2CC[C@H](c3ccccc3)C2)cs1 | 10.1021/acs.jmedchem.8b00718 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | nan | ||
| 44335571 | 5200 | 0 | None | -128 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 3.3 | N#Cc1ccc(-c2ccc(OCCCN3CCOCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL106483 | 5200 | 0 | None | -128 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 3.3 | N#Cc1ccc(-c2ccc(OCCCN3CCOCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 40011786 | 68686 | 4 | None | -32 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 282 | 2 | 0 | 4 | 2.7 | c1ccc2c(N3CCN(C4CCCC4)CC3)ncnc2c1 | 10.1021/jm2011589 | ||
| CHEMBL1923530 | 68686 | 4 | None | -32 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 282 | 2 | 0 | 4 | 2.7 | c1ccc2c(N3CCN(C4CCCC4)CC3)ncnc2c1 | 10.1021/jm2011589 | ||
| 25491778 | 162115 | 1 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 378 | 6 | 0 | 5 | 5.1 | CO[C@@H]1CCCN(Cc2nc(-c3cccc(Oc4ccccc4)c3)oc2C)C1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4170001 | 162115 | 1 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 378 | 6 | 0 | 5 | 5.1 | CO[C@@H]1CCCN(Cc2nc(-c3cccc(Oc4ccccc4)c3)oc2C)C1 | 10.1021/acs.jmedchem.8b00718 | ||
| 11023546 | 78069 | 0 | None | 2 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 317 | 1 | 0 | 4 | 3.1 | CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| CHEMBL2111783 | 78069 | 0 | None | 2 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 317 | 1 | 0 | 4 | 3.1 | CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm049632c | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm049632c | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm049632c | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm049632c | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm049632c | ||
| 44401194 | 70951 | 0 | None | -4 | 7 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 2 | 0 | 3 | 4.1 | CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL195706 | 70951 | 0 | None | -4 | 7 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 313 | 2 | 0 | 3 | 4.1 | CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 56835171 | 69397 | 0 | None | -204 | 9 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 295 | 2 | 2 | 6 | 1.9 | Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1 | 10.1016/j.bmcl.2011.10.104 | ||
| CHEMBL1935574 | 69397 | 0 | None | -204 | 9 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 295 | 2 | 2 | 6 | 1.9 | Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1 | 10.1016/j.bmcl.2011.10.104 | ||
| 44304412 | 199963 | 0 | None | -223 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 517 | 13 | 1 | 6 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60598 | 199963 | 0 | None | -223 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 517 | 13 | 1 | 6 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](NC(=O)OC(C)(C)C)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304753 | 201505 | 0 | None | -363 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 13 | 1 | 6 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)Cc3ccncc3)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64321 | 201505 | 0 | None | -363 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 466 | 13 | 1 | 6 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)Cc3ccncc3)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 112936267 | 136771 | 1 | None | 2 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 373 | 6 | 1 | 5 | 3.6 | CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752383 | 136771 | 1 | None | 2 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 373 | 6 | 1 | 5 | 3.6 | CN1CCN(c2cc(-c3ccccc3)nc(NCCc3ccccc3)n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 132060776 | 161852 | 0 | None | -1 | 16 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 419 | 4 | 0 | 4 | 4.4 | O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4165863 | 161852 | 0 | None | -1 | 16 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 419 | 4 | 0 | 4 | 4.4 | O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 | 10.1016/j.ejmech.2018.02.024 | ||
| 168296769 | 191734 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 758 | 20 | 7 | 9 | 0.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5206578 | 191734 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 758 | 20 | 7 | 9 | 0.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304256 | 167456 | 0 | None | -123 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 360 | 12 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(CCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL432144 | 167456 | 0 | None | -123 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 360 | 12 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(CCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 127035836 | 136993 | 0 | None | 5 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 399 | 4 | 1 | 5 | 3.9 | Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3754176 | 136993 | 0 | None | 5 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 399 | 4 | 1 | 5 | 3.9 | Cc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| 71525678 | 89295 | 0 | None | -3548 | 6 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 258 | 3 | 2 | 6 | 0.6 | CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1 | 10.1016/j.bmcl.2013.02.091 | ||
| CHEMBL2376800 | 89295 | 0 | None | -3548 | 6 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 258 | 3 | 2 | 6 | 0.6 | CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1 | 10.1016/j.bmcl.2013.02.091 | ||
| 129103322 | 166819 | 0 | None | -53 | 6 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 463 | 6 | 1 | 5 | 4.5 | O=C1CCc2cc(C(O)CCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3 | 10.1021/acs.jmedchem.8b01096 | ||
| CHEMBL4294799 | 166819 | 0 | None | -53 | 6 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 463 | 6 | 1 | 5 | 4.5 | O=C1CCc2cc(C(O)CCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3 | 10.1021/acs.jmedchem.8b01096 | ||
| 168296769 | 191734 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 758 | 20 | 7 | 9 | 0.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5206578 | 191734 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 758 | 20 | 7 | 9 | 0.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 2812 | 4711 | 96 | None | -28 | 34 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| CHEMBL104 | 4711 | 96 | None | -28 | 34 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| 44335384 | 4570 | 0 | None | -489 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.9 | CC1CCCCN1CCCOc1ccc(-c2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL102984 | 4570 | 0 | None | -489 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.9 | CC1CCCCN1CCCOc1ccc(-c2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 44304277 | 100480 | 0 | None | -457 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 2.4 | CN[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)C(C)C | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL294087 | 100480 | 0 | None | -457 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 2.4 | CN[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)C(C)C | 10.1016/s0960-894x(02)00310-4 | ||
| 46884638 | 7643 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1cnc(CC2=C(CCN(C)C)Cc3ccccc32)cn1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1088899 | 7643 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1cnc(CC2=C(CCN(C)C)Cc3ccccc32)cn1 | 10.1016/j.bmcl.2010.02.055 | ||
| 155566038 | 175169 | 0 | None | 26 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 5 | 1 | 4 | 1.5 | CN1CCc2ccc(OCCCN3CCC(O)CC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4583183 | 175169 | 0 | None | 26 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 318 | 5 | 1 | 4 | 1.5 | CN1CCc2ccc(OCCCN3CCC(O)CC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 51111982 | 162028 | 6 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 344 | 5 | 0 | 4 | 3.2 | N#Cc1c(CN2CCN(CCc3ccccc3)CC2)cn2ccccc12 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4168691 | 162028 | 6 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 344 | 5 | 0 | 4 | 3.2 | N#Cc1c(CN2CCN(CCc3ccccc3)CC2)cn2ccccc12 | 10.1021/acs.jmedchem.8b00718 | ||
| 11623845 | 8239 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 4.6 | CC(c1nccs1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092767 | 8239 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 4.6 | CC(c1nccs1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm00105a069 | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm00105a069 | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm00105a069 | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm00105a069 | ||
| 44335351 | 4998 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 402 | 7 | 0 | 4 | 4.6 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Cl)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105385 | 4998 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 402 | 7 | 0 | 4 | 4.6 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(Cl)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 44304021 | 102322 | 0 | None | -9 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 3.4 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C=C(C)C)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL305313 | 102322 | 0 | None | -9 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 3.4 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C=C(C)C)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 10069595 | 201438 | 0 | None | -112 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 400 | 11 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CCC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64100 | 201438 | 0 | None | -112 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 400 | 11 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C3CCC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335350 | 5011 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 398 | 8 | 0 | 5 | 3.9 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105483 | 5011 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 398 | 8 | 0 | 5 | 3.9 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 44335336 | 4490 | 0 | None | -27 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 335 | 6 | 1 | 4 | 3.4 | N#Cc1ccc(-c2ccc(OCCCN3CCC(N)CC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL102452 | 4490 | 0 | None | -27 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 335 | 6 | 1 | 4 | 3.4 | N#Cc1ccc(-c2ccc(OCCCN3CCC(N)CC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 25109291 | 190792 | 9 | None | -83176 | 8 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 327 | 1 | 2 | 6 | 1.7 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | 10.1021/jm8007618 | ||
| CHEMBL519240 | 190792 | 9 | None | -83176 | 8 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 327 | 1 | 2 | 6 | 1.7 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | 10.1021/jm8007618 | ||
| 168273640 | 192203 | 0 | None | -100 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 568 | 15 | 8 | 10 | -0.1 | N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5176229 | 192203 | 0 | None | -100 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 568 | 15 | 8 | 10 | -0.1 | N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221444 | 192203 | 0 | None | -100 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 568 | 15 | 8 | 10 | -0.1 | N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44304012 | 201144 | 0 | None | -18620 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 389 | 11 | 1 | 5 | 2.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)N)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62421 | 201144 | 0 | None | -18620 | 3 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 389 | 11 | 1 | 5 | 2.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)N)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44289035 | 100048 | 0 | None | -186 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 524 | 7 | 1 | 4 | 4.4 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL291166 | 100048 | 0 | None | -186 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 524 | 7 | 1 | 4 | 4.4 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| 50985821 | 175644 | 25 | None | -2 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 474 | 5 | 2 | 5 | 6.2 | N=c1c2c(-c3ccccc3)c(-c3ccccc3)n(Cc3ccccc3)c2ncn1[C@H]1CC[C@H](O)CC1 | 10.1021/acs.jmedchem.2c00204 | ||
| CHEMBL4594433 | 175644 | 25 | None | -2 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 474 | 5 | 2 | 5 | 6.2 | N=c1c2c(-c3ccccc3)c(-c3ccccc3)n(Cc3ccccc3)c2ncn1[C@H]1CC[C@H](O)CC1 | 10.1021/acs.jmedchem.2c00204 | ||
| 44343572 | 10189 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 383 | 3 | 0 | 3 | 3.9 | CCCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL116144 | 10189 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 383 | 3 | 0 | 3 | 3.9 | CCCC(=O)N1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 71457970 | 78061 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 355 | 1 | 0 | 3 | 3.1 | CC(=O)N1CCN([C@@H]2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL2111767 | 78061 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 355 | 1 | 0 | 3 | 3.1 | CC(=O)N1CCN([C@@H]2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 19918406 | 110871 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 367 | 1 | 0 | 3 | 3.2 | O=C1CCC2CN(C3c4ccc(Cl)cc4CCc4cccnc43)CCN12 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL326978 | 110871 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 367 | 1 | 0 | 3 | 3.2 | O=C1CCC2CN(C3c4ccc(Cl)cc4CCc4cccnc43)CCN12 | 10.1016/s0960-894x(98)00626-x | ||
| 11848625 | 5715 | 0 | None | -38 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.9 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1 | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1078745 | 5715 | 0 | None | -38 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.9 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1 | 10.1016/j.bmcl.2009.09.024 | ||
| 44334407 | 108598 | 0 | None | -1202 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 462 | 10 | 1 | 5 | 3.8 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL321320 | 108598 | 0 | None | -1202 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 462 | 10 | 1 | 5 | 3.8 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 56835171 | 69397 | 0 | None | -223 | 9 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 295 | 2 | 2 | 6 | 1.9 | Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1 | 10.1016/j.bmcl.2011.10.104 | ||
| CHEMBL1935574 | 69397 | 0 | None | -223 | 9 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 295 | 2 | 2 | 6 | 1.9 | Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1 | 10.1016/j.bmcl.2011.10.104 | ||
| 127052465 | 140200 | 0 | None | -97 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.6 | O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3817911 | 140200 | 0 | None | -97 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.6 | O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 | 10.1016/j.bmc.2016.05.053 | ||
| 127052465 | 140200 | 0 | None | -97 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.6 | O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3817911 | 140200 | 0 | None | -97 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 340 | 5 | 0 | 3 | 3.6 | O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1 | 10.1016/j.bmc.2016.05.053 | ||
| 162662563 | 181464 | 0 | None | -61 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 391 | 7 | 0 | 4 | 4.5 | Fc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4781093 | 181464 | 0 | None | -61 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 391 | 7 | 0 | 4 | 4.5 | Fc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm049495j | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm049495j | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm049495j | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm049495j | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1021/jm049495j | ||
| 10660 | 14298 | 55 | None | 2 | 12 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 469 | 6 | 1 | 7 | 3.0 | CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O | nan | ||
| CHEMBL1200406 | 14298 | 55 | None | 2 | 12 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 469 | 6 | 1 | 7 | 3.0 | CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O | nan | ||
| 44343938 | 112564 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 320 | 1 | 0 | 2 | 3.0 | CC(=O)N1CCN(C2c3ccccc3CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL331159 | 112564 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 320 | 1 | 0 | 2 | 3.0 | CC(=O)N1CCN(C2c3ccccc3CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 44334035 | 109556 | 0 | None | -741 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 476 | 10 | 1 | 7 | 4.1 | O=C(N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1)c1csc(-c2cccnc2)n1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL323517 | 109556 | 0 | None | -741 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 476 | 10 | 1 | 7 | 4.1 | O=C(N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1)c1csc(-c2cccnc2)n1 | 10.1016/s0960-894x(02)00685-6 | ||
| 2771 | 193347 | 67 | None | -2 | 26 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | nan | ||
| CHEMBL1200781 | 193347 | 67 | None | -2 | 26 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | nan | ||
| CHEMBL549 | 193347 | 67 | None | -2 | 26 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | nan | ||
| 168277300 | 189587 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 754 | 19 | 5 | 7 | 3.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5174142 | 189587 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 754 | 19 | 5 | 7 | 3.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| 10268636 | 5211 | 0 | None | -436 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 7 | 1 | 4 | 3.3 | CN[C@@H]1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL106545 | 5211 | 0 | None | -436 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 7 | 1 | 4 | 3.3 | CN[C@@H]1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1 | 10.1016/s0960-894x(02)00648-0 | ||
| 44335222 | 162904 | 0 | None | -1 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 369 | 7 | 0 | 5 | 3.3 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccncc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL419912 | 162904 | 0 | None | -1 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 369 | 7 | 0 | 5 | 3.3 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccncc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168294166 | 192412 | 0 | None | -1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5209081 | 192412 | 0 | None | -1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222775 | 192412 | 0 | None | -1 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1ccc(-c2sc(N)nc2C)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44304329 | 201536 | 0 | None | -1230 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 1.9 | O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64461 | 201536 | 0 | None | -1230 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 1.9 | O=C(c1ccc(OCCCN2CCN(C(=O)[C@H]3CCCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 168277300 | 189587 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 754 | 19 | 5 | 7 | 3.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5174142 | 189587 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 754 | 19 | 5 | 7 | 3.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O)C(C)C | 10.1021/acs.jmedchem.2c00125 | ||
| 71450550 | 83393 | 0 | None | -7 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53 | 10.1016/j.bmcl.2012.08.046 | ||
| CHEMBL2205836 | 83393 | 0 | None | -7 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53 | 10.1016/j.bmcl.2012.08.046 | ||
| 44455426 | 154610 | 0 | None | -5 | 12 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| CHEMBL402143 | 154610 | 0 | None | -5 | 12 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| 9894665 | 103336 | 1 | None | -114 | 8 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 3.3 | CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 | 10.1021/jm9905918 | ||
| CHEMBL309106 | 103336 | 1 | None | -114 | 8 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 3.3 | CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 | 10.1021/jm9905918 | ||
| 46884119 | 8066 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | CC(c1cccc(F)n1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091793 | 8066 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 328 | 5 | 0 | 3 | 4.7 | CC(c1cccc(F)n1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 57334404 | 90081 | 0 | None | -3 | 5 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 512 | 8 | 0 | 6 | 6.8 | O=c1cc(-c2ccccc2)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2o1 | 10.1021/jm400408r | ||
| CHEMBL2387265 | 90081 | 0 | None | -3 | 5 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 512 | 8 | 0 | 6 | 6.8 | O=c1cc(-c2ccccc2)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2o1 | 10.1021/jm400408r | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2015.09.045 | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2015.09.045 | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2015.09.045 | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2015.09.045 | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1016/j.bmcl.2015.09.045 | ||
| 44335368 | 4981 | 0 | None | 2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3cccc(C#N)c3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105268 | 4981 | 0 | None | 2 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3cccc(C#N)c3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 44304282 | 201423 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 8 | 0 | 5 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(C)c3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64021 | 201423 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 8 | 0 | 5 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3cccc(C)c3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 11808247 | 17891 | 0 | None | -4 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL126667 | 17891 | 0 | None | -4 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819366 | 17891 | 0 | None | -4 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 127052294 | 139772 | 0 | None | -15 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3806079 | 139772 | 0 | None | -15 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 164610892 | 184615 | 0 | None | -53 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 394 | 8 | 4 | 4 | 3.2 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4857560 | 184615 | 0 | None | -53 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 394 | 8 | 4 | 4 | 3.2 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1 | 10.1016/j.ejmech.2021.113190 | ||
| 11808247 | 17891 | 0 | None | -4 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL126667 | 17891 | 0 | None | -4 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819366 | 17891 | 0 | None | -4 | 9 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 285 | 5 | 0 | 2 | 3.7 | Fc1ccc(OCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 71452382 | 83380 | 0 | None | -120 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1 | 10.1016/j.bmcl.2012.08.046 | ||
| CHEMBL2205812 | 83380 | 0 | None | -120 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1 | 10.1016/j.bmcl.2012.08.046 | ||
| 1353 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm010982y | ||
| 3559 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm010982y | ||
| 86 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm010982y | ||
| CHEMBL54 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm010982y | ||
| DB00502 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm010982y | ||
| 1353 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0309811 | ||
| 3559 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0309811 | ||
| 86 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0309811 | ||
| CHEMBL54 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0309811 | ||
| DB00502 | 1880 | 85 | None | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm0309811 | ||
| 46882224 | 6271 | 0 | None | -354 | 5 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 543 | 10 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1 | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1082036 | 6271 | 0 | None | -354 | 5 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 543 | 10 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1 | 10.1016/j.bmcl.2009.09.024 | ||
| 20293994 | 198133 | 8 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 239 | 6 | 1 | 1 | 3.8 | CNCCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL594138 | 198133 | 8 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 239 | 6 | 1 | 1 | 3.8 | CNCCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 11393516 | 5102 | 0 | None | -467 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 6 | 1 | 4 | 3.3 | N#Cc1ccc(-c2ccc(OCCCN3CCCNCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105967 | 5102 | 0 | None | -467 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 6 | 1 | 4 | 3.3 | N#Cc1ccc(-c2ccc(OCCCN3CCCNCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 69355600 | 78275 | 0 | None | -954 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 336 | 6 | 1 | 4 | 3.5 | C[C@@]1(O)CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL2112461 | 78275 | 0 | None | -954 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 336 | 6 | 1 | 4 | 3.5 | C[C@@]1(O)CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)C1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168278543 | 192249 | 0 | None | -2 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 358 | 4 | 4 | 4 | 1.6 | N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5184846 | 192249 | 0 | None | -2 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 358 | 4 | 4 | 4 | 1.6 | N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221764 | 192249 | 0 | None | -2 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 358 | 4 | 4 | 4 | 1.6 | N/C(=N\C(=O)NCc1ccccc1)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168284289 | 192304 | 0 | None | -3 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 428 | 8 | 4 | 4 | 3.1 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5194860 | 192304 | 0 | None | -3 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 428 | 8 | 4 | 4 | 3.1 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222123 | 192304 | 0 | None | -3 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 428 | 8 | 4 | 4 | 3.1 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44301729 | 199257 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 11 | 2 | 3 | 5.0 | Clc1ccc(C(CCNCCCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL60175 | 199257 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 382 | 11 | 2 | 3 | 5.0 | Clc1ccc(C(CCNCCCCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00357-3 | ||
| 141485892 | 170411 | 0 | None | 4 | 2 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 288 | 5 | 0 | 3 | 2.2 | CN1CCc2ccc(OCCCN3CCCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4456092 | 170411 | 0 | None | 4 | 2 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 288 | 5 | 0 | 3 | 2.2 | CN1CCc2ccc(OCCCN3CCCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 44622872 | 196039 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 413 | 8 | 1 | 2 | 6.0 | Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL571389 | 196039 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 413 | 8 | 1 | 2 | 6.0 | Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 66615619 | 80859 | 0 | None | -79 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158783 | 80859 | 0 | None | -79 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.7 | Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 71462103 | 80890 | 1 | None | 2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158830 | 80890 | 1 | None | 2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59296099 | 83676 | 0 | None | -50 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 494 | 7 | 3 | 5 | 3.7 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207660 | 83676 | 0 | None | -50 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 494 | 7 | 3 | 5 | 3.7 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 2337 | 3205 | 72 | None | -1 | 62 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm070516u | ||
| 50 | 3205 | 72 | None | -1 | 62 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm070516u | ||
| 5002 | 3205 | 72 | None | -1 | 62 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm070516u | ||
| CHEMBL716 | 3205 | 72 | None | -1 | 62 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm070516u | ||
| DB01224 | 3205 | 72 | None | -1 | 62 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1021/jm070516u | ||
| 71449859 | 81836 | 0 | None | 10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 600 | 10 | 1 | 8 | 5.1 | O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171029 | 81836 | 0 | None | 10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 600 | 10 | 1 | 8 | 5.1 | O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963347 | 81852 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 579 | 5 | 1 | 5 | 5.4 | O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171045 | 81852 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 579 | 5 | 1 | 5 | 5.4 | O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 11702578 | 8064 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1ccnc(C(C)c2c(CCN(C)C)sc3ccccc23)c1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091791 | 8064 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1ccnc(C(C)c2c(CCN(C)C)sc3ccccc23)c1 | 10.1016/j.bmcl.2010.01.134 | ||
| 25212275 | 173849 | 0 | None | -9332 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL455288 | 173849 | 0 | None | -9332 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 10436842 | 99792 | 0 | None | -501 | 7 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 524 | 7 | 1 | 4 | 4.6 | CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL288772 | 99792 | 0 | None | -501 | 7 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 524 | 7 | 1 | 4 | 4.6 | CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| 44304247 | 201121 | 0 | None | -38 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 412 | 11 | 0 | 5 | 4.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccco3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62312 | 201121 | 0 | None | -38 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 412 | 11 | 0 | 5 | 4.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccco3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 71451390 | 80854 | 0 | None | -7 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 474 | 8 | 1 | 4 | 4.7 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158778 | 80854 | 0 | None | -7 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 474 | 8 | 1 | 4 | 4.7 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 1353 | 1880 | 85 | None | -213 | 85 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
| 3559 | 1880 | 85 | None | -213 | 85 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
| 86 | 1880 | 85 | None | -213 | 85 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
| CHEMBL54 | 1880 | 85 | None | -213 | 85 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
| DB00502 | 1880 | 85 | None | -213 | 85 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm070516u | ||
| 44304291 | 201164 | 0 | None | -891 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 388 | 11 | 0 | 4 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62527 | 201164 | 0 | None | -891 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 388 | 11 | 0 | 4 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)C(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335238 | 5020 | 0 | None | -1862 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 5.3 | CC1CCCC(C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105515 | 5020 | 0 | None | -1862 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 348 | 6 | 0 | 3 | 5.3 | CC1CCCC(C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168294182 | 192446 | 0 | None | -57 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 314 | 6 | 4 | 2 | 1.7 | C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208722 | 192446 | 0 | None | -57 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 314 | 6 | 4 | 2 | 1.7 | C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222960 | 192446 | 0 | None | -57 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 314 | 6 | 4 | 2 | 1.7 | C[C@@H](NC(=O)/N=C(\N)NCCCc1c[nH]cn1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 10017820 | 202494 | 0 | None | -199 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 302 | 8 | 3 | 2 | 2.8 | S=C(NCCCCCc1c[nH]cn1)NCc1ccccc1 | 10.1021/jm00012a025 | ||
| CHEMBL70811 | 202494 | 0 | None | -199 | 3 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 302 | 8 | 3 | 2 | 2.8 | S=C(NCCCCCc1c[nH]cn1)NCc1ccccc1 | 10.1021/jm00012a025 | ||
| 18878 | 143671 | 83 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 177 | 2 | 1 | 2 | 1.8 | c1ccc(OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3904359 | 143671 | 83 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 177 | 2 | 1 | 2 | 1.8 | c1ccc(OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 10686633 | 56238 | 0 | None | -1621 | 2 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.6 | O=C(Nc1ccccc1C(F)(F)F)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16373 | 56238 | 0 | None | -1621 | 2 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.6 | O=C(Nc1ccccc1C(F)(F)F)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10682710 | 57191 | 1 | None | -3801 | 2 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.3 | O=C(NCc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16592 | 57191 | 1 | None | -3801 | 2 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.3 | O=C(NCc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10474353 | 58469 | 0 | None | -4168 | 2 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 371 | 5 | 2 | 3 | 3.2 | O=C(Nc1ccc(I)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16874 | 58469 | 0 | None | -4168 | 2 | Guinea pig | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 371 | 5 | 2 | 3 | 3.2 | O=C(Nc1ccc(I)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 2775690 | 92579 | 47 | None | -15 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 1 | 1 | 3 | 3.0 | Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1 | 10.1021/ml400312j | ||
| CHEMBL2441619 | 92579 | 47 | None | -15 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 1 | 1 | 3 | 3.0 | Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1 | 10.1021/ml400312j | ||
| 11265950 | 194239 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL559251 | 194239 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11265950 | 194239 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL559251 | 194239 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 11265950 | 194239 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1021/jm900933k | ||
| CHEMBL559251 | 194239 | 0 | None | -6 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1021/jm900933k | ||
| 11580427 | 194935 | 9 | None | -23 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1021/jm900933k | ||
| CHEMBL564144 | 194935 | 9 | None | -23 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1021/jm900933k | ||
| 11465618 | 101926 | 18 | None | -14 | 19 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | ||
| CHEMBL3039528 | 101926 | 18 | None | -14 | 19 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | ||
| CHEMBL5191141 | 101926 | 18 | None | -14 | 19 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | ||
| 44312705 | 102624 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 454 | 7 | 2 | 5 | 4.1 | NC(=O)N(O)Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL307609 | 102624 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 454 | 7 | 2 | 5 | 4.1 | NC(=O)N(O)Cc1ccc(CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)o1 | 10.1016/j.bmcl.2004.02.005 | ||
| 11580427 | 194935 | 9 | None | -23 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.07.117 | ||
| CHEMBL564144 | 194935 | 9 | None | -23 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.07.117 | ||
| 46884699 | 8221 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 307 | 5 | 0 | 3 | 3.9 | Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092663 | 8221 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 307 | 5 | 0 | 3 | 3.9 | Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| 14127191 | 11192 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL1179239 | 11192 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL65822 | 11192 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 323 | 4 | 1 | 3 | 3.7 | CN(C)CC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 15749428 | 100409 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.0 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CCC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL293652 | 100409 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.0 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CCC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 9805944 | 55934 | 31 | None | -6 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm800510m | ||
| CHEMBL1627 | 55934 | 31 | None | -6 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm800510m | ||
| 2726 | 906 | 64 | None | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| 621 | 906 | 64 | None | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| 83 | 906 | 64 | None | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL71 | 906 | 64 | None | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| DB00477 | 906 | 64 | None | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | ||
| 44326336 | 110925 | 0 | None | 5 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 311 | 2 | 0 | 3 | 4.3 | CN(C)CC1C[C@@H]2c3ccccc3Sc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL327306 | 110925 | 0 | None | 5 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 311 | 2 | 0 | 3 | 4.3 | CN(C)CC1C[C@@H]2c3ccccc3Sc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 53320189 | 57450 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 291 | 5 | 0 | 3 | 3.1 | c1ccc2c(c1)CC(CCN1CCC1)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669412 | 57450 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 291 | 5 | 0 | 3 | 3.1 | c1ccc2c(c1)CC(CCN1CCC1)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 9949441 | 113963 | 0 | None | 2 | 5 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 331 | 2 | 0 | 4 | 3.5 | CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| CHEMBL333455 | 113963 | 0 | None | 2 | 5 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 331 | 2 | 0 | 4 | 3.5 | CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| 135398745 | 2869 | 108 | None | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0309811 | ||
| 47 | 2869 | 108 | None | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0309811 | ||
| CHEMBL715 | 2869 | 108 | None | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0309811 | ||
| DB00334 | 2869 | 108 | None | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0309811 | ||
| 44401243 | 167929 | 0 | None | -1 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.6 | CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL435301 | 167929 | 0 | None | -1 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.6 | CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 46830289 | 8275 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 299 | 5 | 0 | 4 | 3.8 | C[C@H](c1c(CCN(C)C)sc2ccccc12)n1cccn1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1093058 | 8275 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 299 | 5 | 0 | 4 | 3.8 | C[C@H](c1c(CCN(C)C)sc2ccccc12)n1cccn1 | 10.1016/j.bmcl.2010.01.134 | ||
| 6726 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 7151 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 749 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL648 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| DB01176 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/j.bmcl.2013.12.024 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 10.1016/j.bmcl.2011.09.001 | ||
| 49782794 | 17734 | 0 | None | -16 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 409 | 4 | 1 | 4 | 4.0 | CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| CHEMBL1259189 | 17734 | 0 | None | -16 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 409 | 4 | 1 | 4 | 4.0 | CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| 45272889 | 194226 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 6 | 1 | 5 | 4.2 | Fc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL559060 | 194226 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 6 | 1 | 5 | 4.2 | Fc1ccc(Cn2c(N3CCC(NCC4CCOCC4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | nan | ||
| 25056048 | 102140 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.0 | CN(C)CCC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL304185 | 102140 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 4.0 | CN(C)CCC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 46884201 | 8061 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 4.6 | C[C@@H](c1cscn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091782 | 8061 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 4.6 | C[C@@H](c1cscn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 11023546 | 78069 | 0 | None | 2 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 317 | 1 | 0 | 4 | 3.1 | CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| CHEMBL2111783 | 78069 | 0 | None | 2 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 317 | 1 | 0 | 4 | 3.1 | CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| 1212 | 1632 | 45 | None | -41 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| 204 | 1632 | 45 | None | -41 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| 3372 | 1632 | 45 | None | -41 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| CHEMBL726 | 1632 | 45 | None | -41 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| DB00623 | 1632 | 45 | None | -41 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | nan | ||
| 49836299 | 18557 | 0 | None | 10 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| CHEMBL1277770 | 18557 | 0 | None | 10 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 375 | 2 | 1 | 2 | 4.4 | O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1 | 10.1021/jm100856p | ||
| 46889258 | 7460 | 0 | None | 316 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 302 | 6 | 0 | 5 | 2.2 | CCOCCn1c(N2CC[C@H](N(C)C)C2)nc2ccccc21 | 10.1016/j.bmcl.2010.03.027 | ||
| CHEMBL1087493 | 7460 | 0 | None | 316 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 302 | 6 | 0 | 5 | 2.2 | CCOCCn1c(N2CC[C@H](N(C)C)C2)nc2ccccc21 | 10.1016/j.bmcl.2010.03.027 | ||
| 51039226 | 57463 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 370 | 7 | 0 | 4 | 4.5 | C[C@H](C1=C(CCN(C)Cc2ccncc2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669425 | 57463 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 370 | 7 | 0 | 4 | 4.5 | C[C@H](C1=C(CCN(C)Cc2ccncc2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 44267118 | 9606 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 396 | 1 | 1 | 3 | 4.3 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C(C)O)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL11313 | 9606 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 396 | 1 | 1 | 3 | 4.3 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C(C)O)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 17867054 | 48676 | 0 | None | -1 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 435 | 5 | 0 | 5 | 4.3 | Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL15601 | 48676 | 0 | None | -1 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 435 | 5 | 0 | 5 | 4.3 | Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 137646281 | 157264 | 0 | None | -91 | 17 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
| CHEMBL4083252 | 157264 | 0 | None | -91 | 17 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
| 72152557 | 162522 | 5 | None | -1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 6 | 1 | 5 | 2.8 | Clc1cncc(NCCCN2CCN(c3ccccc3)CC2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4176490 | 162522 | 5 | None | -1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 331 | 6 | 1 | 5 | 2.8 | Clc1cncc(NCCCN2CCN(c3ccccc3)CC2)n1 | 10.1021/acs.jmedchem.8b00718 | ||
| 1212 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | ||
| 204 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | ||
| 3372 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL726 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | ||
| DB00623 | 1632 | 45 | None | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | ||
| 25212276 | 189473 | 0 | None | -112 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL517244 | 189473 | 0 | None | -112 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/j.bmcl.2009.07.047 | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/j.bmcl.2009.07.047 | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/j.bmcl.2009.07.047 | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1016/j.bmcl.2009.07.047 | ||
| 44308991 | 162945 | 0 | None | -8 | 2 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 435 | 12 | 1 | 5 | 3.8 | O=S(=O)(c1ccc(Cl)cc1)N(CCCCc1c[nH]cn1)CCCCn1ccnc1 | 10.1016/s0960-894x(98)00379-5 | ||
| CHEMBL420181 | 162945 | 0 | None | -8 | 2 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 435 | 12 | 1 | 5 | 3.8 | O=S(=O)(c1ccc(Cl)cc1)N(CCCCc1c[nH]cn1)CCCCn1ccnc1 | 10.1016/s0960-894x(98)00379-5 | ||
| 11580427 | 194935 | 9 | None | -23 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL564144 | 194935 | 9 | None | -23 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 168296738 | 191671 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 714 | 18 | 6 | 8 | 1.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5205682 | 191671 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 714 | 18 | 6 | 8 | 1.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168296738 | 191671 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 714 | 18 | 6 | 8 | 1.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5205682 | 191671 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 714 | 18 | 6 | 8 | 1.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 9818650 | 201831 | 0 | None | -1621 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 4.4 | c1ccc2c(NCCCN3CCCC3)c3c(nc2c1)CCCCC3 | 10.1016/s0960-894x(03)00356-1 | ||
| CHEMBL66388 | 201831 | 0 | None | -1621 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 323 | 5 | 1 | 3 | 4.4 | c1ccc2c(NCCCN3CCCC3)c3c(nc2c1)CCCCC3 | 10.1016/s0960-894x(03)00356-1 | ||
| 162664702 | 181628 | 0 | None | -29 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 407 | 7 | 0 | 4 | 5.0 | Clc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4783066 | 181628 | 0 | None | -29 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 407 | 7 | 0 | 4 | 5.0 | Clc1ccc(-c2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 53326712 | 57443 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 307 | 7 | 0 | 3 | 3.8 | CCCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669406 | 57443 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 307 | 7 | 0 | 3 | 3.8 | CCCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 10480204 | 116027 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 5.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccc(F)cc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL336204 | 116027 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 5.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccc(F)cc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C4MD00578C | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C4MD00578C | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C4MD00578C | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C4MD00578C | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C4MD00578C | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2004.08.060 | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2004.08.060 | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2004.08.060 | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 10.1016/j.bmcl.2004.08.060 | ||
| 13091358 | 70112 | 0 | None | -1023 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946122 | 70112 | 0 | None | -1023 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 13091356 | 113039 | 0 | None | -1023 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL3321789 | 113039 | 0 | None | -1023 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.8 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| 44304376 | 201281 | 0 | None | -7 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 423 | 11 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccn3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL63036 | 201281 | 0 | None | -7 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 423 | 11 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccccn3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 10455457 | 201712 | 0 | None | -707 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 431 | 10 | 0 | 5 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCOCC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL65518 | 201712 | 0 | None | -707 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 431 | 10 | 0 | 5 | 3.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)N3CCOCC3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 112936352 | 136969 | 1 | None | 17 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 3.5 | COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3754008 | 136969 | 1 | None | 17 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 3.5 | COc1ccc(CNc2cc(-c3ccccc3)nc(N3CCN(C)CC3)n2)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| 873049 | 68687 | 8 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 269 | 3 | 0 | 5 | 2.2 | c1ccc2c(c1)n(CCN1CCCCC1)c1ncnn21 | 10.1021/jm2011589 | ||
| CHEMBL1923531 | 68687 | 8 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 269 | 3 | 0 | 5 | 2.2 | c1ccc2c(c1)n(CCN1CCCCC1)c1ncnn21 | 10.1021/jm2011589 | ||
| 73353884 | 91890 | 0 | None | -3 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 295 | 3 | 1 | 3 | 2.7 | c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2 | 10.1016/j.bmc.2013.07.045 | ||
| CHEMBL2429890 | 91890 | 0 | None | -3 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 295 | 3 | 1 | 3 | 2.7 | c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2 | 10.1016/j.bmc.2013.07.045 | ||
| 213 | 3792 | 50 | None | -4 | 43 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| 2717 | 3792 | 50 | None | -4 | 43 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| 5533 | 3792 | 50 | None | -4 | 43 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| CHEMBL621 | 3792 | 50 | None | -4 | 43 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| DB00656 | 3792 | 50 | None | -4 | 43 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | nan | ||
| 9864676 | 127286 | 0 | None | -2 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 4.5 | O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| CHEMBL366388 | 127286 | 0 | None | -2 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 4.5 | O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| 44401105 | 69233 | 0 | None | -4 | 9 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 2 | 0 | 3 | 4.7 | CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL193435 | 69233 | 0 | None | -4 | 9 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 2 | 0 | 3 | 4.7 | CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 10000169 | 22022 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 3.4 | O=C(O)c1ccc2c(c1)C(SCCN1CCOCC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL132306 | 22022 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 3.4 | O=C(O)c1ccc2c(c1)C(SCCN1CCOCC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 129103161 | 166517 | 0 | None | -588 | 13 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 4.6 | O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 | 10.1021/acs.jmedchem.8b01096 | ||
| CHEMBL4289498 | 166517 | 0 | None | -588 | 13 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 4.6 | O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 | 10.1021/acs.jmedchem.8b01096 | ||
| 162657344 | 180350 | 0 | None | -489 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 388 | 8 | 1 | 5 | 4.4 | c1ccc(Nc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4758080 | 180350 | 0 | None | -489 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 388 | 8 | 1 | 5 | 4.4 | c1ccc(Nc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 162666847 | 181875 | 0 | None | -239 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 387 | 8 | 0 | 4 | 4.3 | c1ccc(Cc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4786308 | 181875 | 0 | None | -239 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 387 | 8 | 0 | 4 | 4.3 | c1ccc(Cc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 95232163 | 162539 | 1 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 338 | 7 | 1 | 5 | 1.5 | O[C@@H](COC[C@@H]1CCCO1)CN1CCN(c2ccccc2F)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4176800 | 162539 | 1 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 338 | 7 | 1 | 5 | 1.5 | O[C@@H](COC[C@@H]1CCCO1)CN1CCN(c2ccccc2F)CC1 | 10.1021/acs.jmedchem.8b00718 | ||
| 44304304 | 169496 | 0 | None | -67 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 423 | 9 | 0 | 6 | 3.5 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3cccnc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL444307 | 169496 | 0 | None | -67 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 423 | 9 | 0 | 6 | 3.5 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3cccnc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335558 | 109581 | 0 | None | -43 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.7 | CC1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL323562 | 109581 | 0 | None | -43 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.7 | CC1CCN(CCCOc2ccc(-c3ccc(C#N)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 3300652 | 68680 | 33 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 263 | 1 | 2 | 5 | 2.3 | NC1=NC(c2ccccc2)n2c(nc3ccccc32)N1 | 10.1021/jm2011589 | ||
| CHEMBL1923523 | 68680 | 33 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 263 | 1 | 2 | 5 | 2.3 | NC1=NC(c2ccccc2)n2c(nc3ccccc32)N1 | 10.1021/jm2011589 | ||
| 44304032 | 199802 | 0 | None | -95 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 413 | 11 | 0 | 6 | 3.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnco3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL60509 | 199802 | 0 | None | -95 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 413 | 11 | 0 | 6 | 3.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cnco3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 129103315 | 166569 | 0 | None | -5 | 6 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 477 | 7 | 1 | 5 | 4.9 | O=C1CCc2cc(C(O)CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3 | 10.1021/acs.jmedchem.8b01096 | ||
| CHEMBL4290311 | 166569 | 0 | None | -5 | 6 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 477 | 7 | 1 | 5 | 4.9 | O=C1CCc2cc(C(O)CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3 | 10.1021/acs.jmedchem.8b01096 | ||
| 127041705 | 136153 | 0 | None | -1 | 5 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 525 | 5 | 0 | 5 | 5.3 | O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCC(CN2CCC(c3noc4cc(F)ccc34)CC2)CC1 | 10.1039/C4MD00578C | ||
| CHEMBL3740256 | 136153 | 0 | None | -1 | 5 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 525 | 5 | 0 | 5 | 5.3 | O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCC(CN2CCC(c3noc4cc(F)ccc34)CC2)CC1 | 10.1039/C4MD00578C | ||
| 44267139 | 9281 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.3 | COc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL11136 | 9281 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 382 | 1 | 0 | 3 | 4.3 | COc1cnc2c(c1)CCc1cc(Cl)ccc1C2=C1CCN(C(C)=O)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 44568347 | 191055 | 0 | None | -20 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.2 | CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21 | 10.1016/j.bmcl.2013.04.082 | ||
| CHEMBL519609 | 191055 | 0 | None | -20 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.2 | CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21 | 10.1016/j.bmcl.2013.04.082 | ||
| 162655547 | 180214 | 0 | None | 20 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 306 | 4 | 0 | 2 | 3.8 | CN(C)CCCN1C(=O)c2ccccc2/C=C\c2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| CHEMBL4756446 | 180214 | 0 | None | 20 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 306 | 4 | 0 | 2 | 3.8 | CN(C)CCCN1C(=O)c2ccccc2/C=C\c2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| 44334503 | 4926 | 0 | None | -281 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 349 | 9 | 3 | 6 | 0.2 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](N)CO)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL104994 | 4926 | 0 | None | -281 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 349 | 9 | 3 | 6 | 0.2 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](N)CO)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44335407 | 171278 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 452 | 8 | 0 | 5 | 4.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL446885 | 171278 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 452 | 8 | 0 | 5 | 4.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168280835 | 190128 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 818 | 20 | 6 | 8 | 3.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5182490 | 190128 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 818 | 20 | 6 | 8 | 3.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168293792 | 191579 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5204037 | 191579 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304293 | 201273 | 0 | None | -15 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 491 | 10 | 1 | 6 | 4.0 | N[C@H](Cc1cc2ccccc2s1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL63002 | 201273 | 0 | None | -15 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 491 | 10 | 1 | 6 | 4.0 | N[C@H](Cc1cc2ccccc2s1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 168280835 | 190128 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 818 | 20 | 6 | 8 | 3.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5182490 | 190128 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 818 | 20 | 6 | 8 | 3.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168293792 | 191579 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5204037 | 191579 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44582678 | 180992 | 0 | None | -3 | 10 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 401 | 9 | 1 | 4 | 4.3 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| CHEMBL476839 | 180992 | 0 | None | -3 | 10 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 401 | 9 | 1 | 4 | 4.3 | COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| 71937057 | 119070 | 4 | None | -1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 6 | 2 | 4 | 2.0 | Cc1cccc(N2CCN(CCCNC(=O)c3cn[nH]c3C)CC2)c1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL3461530 | 119070 | 4 | None | -1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 6 | 2 | 4 | 2.0 | Cc1cccc(N2CCN(CCCNC(=O)c3cn[nH]c3C)CC2)c1 | 10.1021/acs.jmedchem.8b00718 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2008.06.030 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2014.07.018 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2011.12.019 | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2011.12.019 | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2011.12.019 | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmc.2011.12.019 | ||
| 44334781 | 5334 | 0 | None | -1513 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 458 | 11 | 1 | 6 | 3.1 | COc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL107162 | 5334 | 0 | None | -1513 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 458 | 11 | 1 | 6 | 3.1 | COc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 20659961 | 115595 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 434 | 2 | 0 | 2 | 6.2 | O=C(CC1CCCCC1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357045 | 115595 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 434 | 2 | 0 | 2 | 6.2 | O=C(CC1CCCCC1)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 71449142 | 79108 | 0 | None | -7 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 442 | 9 | 0 | 6 | 4.2 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(SC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL2113738 | 79108 | 0 | None | -7 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 442 | 9 | 0 | 6 | 4.2 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(SC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335430 | 5225 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 374 | 7 | 0 | 5 | 4.0 | CCOC(=O)N1CCN(CCCOc2ccc(-c3cccs3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL106602 | 5225 | 0 | None | -1 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 374 | 7 | 0 | 5 | 4.0 | CCOC(=O)N1CCN(CCCOc2ccc(-c3cccs3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 9880208 | 4855 | 0 | None | -537 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.1 | N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](O)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL104669 | 4855 | 0 | None | -537 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.1 | N#Cc1ccc(-c2ccc(OCCCN3CC[C@@H](O)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 164622153 | 184986 | 0 | None | -95 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 394 | 6 | 4 | 4 | 3.0 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4863347 | 184986 | 0 | None | -95 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 394 | 6 | 4 | 4 | 3.0 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 164610824 | 184527 | 0 | None | -30 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 452 | 8 | 4 | 4 | 3.6 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4856200 | 184527 | 0 | None | -30 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 452 | 8 | 4 | 4 | 3.6 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NCC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44334025 | 4479 | 0 | None | -1202 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 462 | 10 | 1 | 5 | 3.8 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3Cl)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL102384 | 4479 | 0 | None | -1202 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 462 | 10 | 1 | 5 | 3.8 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3Cl)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44304223 | 198705 | 0 | None | -48 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 374 | 12 | 0 | 4 | 4.5 | CCCCCC(=O)c1ccc(OCCCN2CCN(CC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL59798 | 198705 | 0 | None | -48 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 374 | 12 | 0 | 4 | 4.5 | CCCCCC(=O)c1ccc(OCCCN2CCN(CC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 57390225 | 67540 | 0 | None | -53 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 469 | 9 | 2 | 5 | 4.1 | COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910384 | 67540 | 0 | None | -53 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 469 | 9 | 2 | 5 | 4.1 | COc1ccc(CN(CCN[C@H]2CCN(C(=O)c3cc4ccccc4[nH]3)C2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 44304049 | 101668 | 0 | None | -165 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 2.9 | N[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)c1ccccc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL302468 | 101668 | 0 | None | -165 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 421 | 9 | 1 | 5 | 2.9 | N[C@@H](C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1)c1ccccc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 17156312 | 68688 | 12 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 215 | 4 | 1 | 2 | 3.4 | CC(C)NCc1ccc(-c2ccccc2)o1 | 10.1021/jm2011589 | ||
| CHEMBL1923532 | 68688 | 12 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 215 | 4 | 1 | 2 | 3.4 | CC(C)NCc1ccc(-c2ccccc2)o1 | 10.1021/jm2011589 | ||
| 44304003 | 201444 | 0 | None | -1584 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 384 | 9 | 1 | 6 | 1.4 | N#CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64124 | 201444 | 0 | None | -1584 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 384 | 9 | 1 | 6 | 1.4 | N#CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 164609493 | 183854 | 0 | None | -2630 | 6 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 350 | 6 | 4 | 5 | 1.9 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4846380 | 183854 | 0 | None | -2630 | 6 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 350 | 6 | 4 | 5 | 1.9 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1 | 10.1016/j.ejmech.2021.113190 | ||
| 162676676 | 183007 | 0 | None | -223 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 389 | 8 | 0 | 5 | 4.5 | c1ccc(Oc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4800672 | 183007 | 0 | None | -223 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 389 | 8 | 0 | 5 | 4.5 | c1ccc(Oc2ccc(OCCCN3CCN(c4ccncc4)CC3)cc2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 60165681 | 75006 | 0 | None | -1 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 413 | 7 | 0 | 5 | 5.1 | O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
| CHEMBL2037528 | 75006 | 0 | None | -1 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 413 | 7 | 0 | 5 | 5.1 | O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/acs.jmedchem.8b01096 | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/acs.jmedchem.8b01096 | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/acs.jmedchem.8b01096 | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/acs.jmedchem.8b01096 | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/acs.jmedchem.8b01096 | ||
| 44324737 | 205508 | 0 | None | -158 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 473 | 6 | 0 | 7 | 3.8 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 | 10.1021/jm049619s | ||
| CHEMBL92860 | 205508 | 0 | None | -158 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 473 | 6 | 0 | 7 | 3.8 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 | 10.1021/jm049619s | ||
| 53326725 | 57453 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 327 | 5 | 0 | 3 | 3.4 | FC1(F)CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669415 | 57453 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 327 | 5 | 0 | 3 | 3.4 | FC1(F)CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 118721934 | 115596 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 423 | 3 | 1 | 3 | 4.6 | CC(C)C[C@@H](N)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| CHEMBL3357049 | 115596 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 423 | 3 | 1 | 3 | 4.6 | CC(C)C[C@@H](N)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm501086v | ||
| 44304320 | 162723 | 0 | None | -1862 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.9 | CC[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL418666 | 162723 | 0 | None | -1862 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.9 | CC[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304449 | 198815 | 0 | None | -323 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 531 | 14 | 1 | 6 | 5.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL59870 | 198815 | 0 | None | -323 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 531 | 14 | 1 | 6 | 5.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304348 | 100136 | 0 | None | -11748 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 387 | 10 | 1 | 5 | 2.3 | CCC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL291821 | 100136 | 0 | None | -11748 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 387 | 10 | 1 | 5 | 2.3 | CCC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304056 | 102251 | 0 | None | -5370 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 2.6 | CC(C)N[C@H](C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL304888 | 102251 | 0 | None | -5370 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 2.6 | CC(C)N[C@H](C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304462 | 201193 | 0 | None | -6606 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 405 | 12 | 2 | 6 | 1.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CO)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62660 | 201193 | 0 | None | -6606 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 405 | 12 | 2 | 6 | 1.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](N)CO)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304316 | 201443 | 0 | None | -389 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 485 | 8 | 0 | 6 | 3.6 | CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64120 | 201443 | 0 | None | -389 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 485 | 8 | 0 | 6 | 3.6 | CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 1278 | 2119 | 79 | None | -1778 | 8 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| 1279 | 2119 | 79 | None | -1778 | 8 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| 4908365 | 2119 | 79 | None | -1778 | 8 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL129198 | 2119 | 79 | None | -1778 | 8 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1016/j.bmcl.2011.09.001 | ||
| 164610289 | 184550 | 0 | None | -77 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 438 | 7 | 4 | 4 | 3.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4856602 | 184550 | 0 | None | -77 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 438 | 7 | 4 | 4 | 3.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 10411944 | 22028 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 460 | 6 | 1 | 5 | 4.9 | O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL132311 | 22028 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 460 | 6 | 1 | 5 | 4.9 | O=C(O)c1ccc2c(c1)C(SCCN1CCN(c3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 44326124 | 106472 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 427 | 3 | 0 | 3 | 6.6 | c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Sc5ccccc5[C@H]4O3)CC2)cc1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL314968 | 106472 | 0 | None | 1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 427 | 3 | 0 | 3 | 6.6 | c1ccc(C2CCN(CC3C[C@@H]4c5ccccc5Sc5ccccc5[C@H]4O3)CC2)cc1 | 10.1016/j.bmcl.2004.03.069 | ||
| 73213195 | 103980 | 0 | None | -1 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL3104092 | 103980 | 0 | None | -1 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| 44326219 | 205429 | 0 | None | -8 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 444 | 3 | 0 | 3 | 5.7 | Clc1cccc(N2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)c1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL92333 | 205429 | 0 | None | -8 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 444 | 3 | 0 | 3 | 5.7 | Clc1cccc(N2CCN(CC3C[C@@H]4c5ccccc5Cc5ccccc5[C@H]4O3)CC2)c1 | 10.1016/j.bmcl.2004.03.069 | ||
| 73355415 | 92101 | 0 | None | -23 | 13 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 277 | 3 | 1 | 1 | 2.1 | C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42 | 10.1016/j.bmc.2013.07.045 | ||
| CHEMBL2432039 | 92101 | 0 | None | -23 | 13 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 277 | 3 | 1 | 1 | 2.1 | C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42 | 10.1016/j.bmc.2013.07.045 | ||
| 44304269 | 100078 | 0 | None | -75 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 423 | 11 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccncc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL291394 | 100078 | 0 | None | -75 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 423 | 11 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccncc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 53325600 | 57458 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 376 | 7 | 0 | 5 | 4.6 | C[C@H](C1=C(CCN(C)Cc2nccs2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669420 | 57458 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 376 | 7 | 0 | 5 | 4.6 | C[C@H](C1=C(CCN(C)Cc2nccs2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 14554129 | 10435 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 366 | 1 | 0 | 2 | 4.7 | CCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL116935 | 10435 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 366 | 1 | 0 | 2 | 4.7 | CCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 46929648 | 16580 | 0 | None | 3 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 355 | 5 | 2 | 3 | 4.3 | FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1 | 10.1021/jm100643t | ||
| CHEMBL1243395 | 16580 | 0 | None | 3 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 355 | 5 | 2 | 3 | 4.3 | FC(F)(F)c1ccc(SC[C@@H](c2c[nH]cn2)C2CCNCC2)cc1 | 10.1021/jm100643t | ||
| 73213195 | 103980 | 0 | None | -1 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL3104092 | 103980 | 0 | None | -1 | 12 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.6 | CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| 44521012 | 198296 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 237 | 3 | 1 | 1 | 3.3 | CNCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL595158 | 198296 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 237 | 3 | 1 | 1 | 3.3 | CNCCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 133 | 2460 | 48 | None | -102 | 42 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 1723 | 2460 | 48 | None | -102 | 42 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 28693 | 2460 | 48 | None | -102 | 42 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| CHEMBL19215 | 2460 | 48 | None | -102 | 42 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| DB13520 | 2460 | 48 | None | -102 | 42 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 132060743 | 161686 | 0 | None | -1 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4163428 | 161686 | 0 | None | -1 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| 164620704 | 185501 | 0 | None | -33 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 416 | 8 | 4 | 4 | 3.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4871482 | 185501 | 0 | None | -33 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 416 | 8 | 4 | 4 | 3.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)c1ccc(C(C)C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44343626 | 113650 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 341 | 1 | 0 | 3 | 2.7 | CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1=O | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL332936 | 113650 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 341 | 1 | 0 | 3 | 2.7 | CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1=O | 10.1016/s0960-894x(98)00626-x | ||
| 53321512 | 57452 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 5 | 0 | 3 | 3.1 | FC1CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669414 | 57452 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 309 | 5 | 0 | 3 | 3.1 | FC1CN(CCC2=C(Cc3cnccn3)c3ccccc3C2)C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 71459761 | 83666 | 0 | None | -81 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 540 | 7 | 0 | 5 | 6.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| CHEMBL2207642 | 83666 | 0 | None | -81 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 540 | 7 | 0 | 5 | 6.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| 10326069 | 39059 | 1 | None | -27 | 9 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 589 | 10 | 3 | 8 | 3.3 | CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm980506g | ||
| CHEMBL147077 | 39059 | 1 | None | -27 | 9 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 589 | 10 | 3 | 8 | 3.3 | CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 | 10.1021/jm980506g | ||
| 25055258 | 11951 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 4.2 | O=C(O)c1ccc2c(c1)/C(=C\CCN1CCCC1)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| CHEMBL1183550 | 11951 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 4.2 | O=C(O)c1ccc2c(c1)/C(=C\CCN1CCCC1)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| CHEMBL304223 | 11951 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 349 | 4 | 1 | 3 | 4.2 | O=C(O)c1ccc2c(c1)/C(=C\CCN1CCCC1)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | ||
| 49782998 | 17735 | 0 | None | -31 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 409 | 4 | 1 | 4 | 4.0 | CC(C)C(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| CHEMBL1259190 | 17735 | 0 | None | -31 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 409 | 4 | 1 | 4 | 4.0 | CC(C)C(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 | 10.1021/jm100652h | ||
| 46884120 | 7973 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091069 | 7973 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 44389293 | 128283 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 577 | 11 | 1 | 6 | 5.7 | COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL366925 | 128283 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 577 | 11 | 1 | 6 | 5.7 | COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 69260946 | 80882 | 1 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158823 | 80882 | 1 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69274365 | 80885 | 1 | None | 7 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158826 | 80885 | 1 | None | 7 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71449585 | 80888 | 0 | None | 7 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158829 | 80888 | 0 | None | 7 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 8 | 1 | 5 | 5.2 | O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59295969 | 83603 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 608 | 10 | 4 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207285 | 83603 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 608 | 10 | 4 | 7 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 71454296 | 83681 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 521 | 7 | 2 | 6 | 3.3 | Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207665 | 83681 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 521 | 7 | 2 | 6 | 3.3 | Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O | 10.1016/j.bmcl.2012.09.112 | ||
| 155521446 | 170016 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.7 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncn2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4450560 | 170016 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.7 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncn2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 10069660 | 205181 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 2 | 0 | 3 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2cccnc2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL90893 | 205181 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 401 | 2 | 0 | 3 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2cccnc2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 28125512 | 201732 | 22 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 5284599 | 201732 | 22 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL65699 | 201732 | 22 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1\c2ccccc2COc2ccc(CC(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 46884202 | 8118 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 4.6 | C[C@@H](c1cncs1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092118 | 8118 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 316 | 5 | 0 | 4 | 4.6 | C[C@@H](c1cncs1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm030480f | ||
| 49836528 | 18471 | 0 | None | 5 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 373 | 2 | 1 | 2 | 4.0 | O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2 | 10.1021/jm100856p | ||
| CHEMBL1276947 | 18471 | 0 | None | 5 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 373 | 2 | 1 | 2 | 4.0 | O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2 | 10.1021/jm100856p | ||
| 57393730 | 67542 | 0 | None | -1 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 579 | 8 | 2 | 6 | 5.0 | O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910386 | 67542 | 0 | None | -1 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 579 | 8 | 2 | 6 | 5.0 | O=C(c1cc2ccccc2[nH]1)N1CCN(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2011.09.001 | ||
| 1210 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 1213 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 2725 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 33036 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 4411 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 616 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 6976 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 716121 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 90475904 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL1201353 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL1554789 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL505 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| DB01114 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| DB13679 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1016/s0960-894x(98)00626-x | ||
| 1210 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 1213 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 2725 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 33036 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 4411 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 616 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 6976 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 716121 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 90475904 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| CHEMBL1201353 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| CHEMBL1554789 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| CHEMBL505 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| DB01114 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| DB13679 | 905 | 45 | None | -7 | 20 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm00105a069 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm0002432 | ||
| 49836633 | 18472 | 0 | None | 1 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 347 | 2 | 1 | 2 | 3.6 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1276948 | 18472 | 0 | None | 1 | 5 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 347 | 2 | 1 | 2 | 3.6 | O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 15749431 | 100526 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 4.1 | CN(C)CCC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL294345 | 100526 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 4.1 | CN(C)CCC/C=C1/c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 4543 | 169982 | 36 | None | -1 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | nan | ||
| CHEMBL1201156 | 169982 | 36 | None | -1 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | nan | ||
| CHEMBL445 | 169982 | 36 | None | -1 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | nan | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.12.023 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 11376787 | 63050 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 591 | 12 | 1 | 6 | 6.1 | CCOC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL179590 | 63050 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 591 | 12 | 1 | 6 | 6.1 | CCOC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 1214 | 2037 | 51 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm049495j | ||
| 1549000 | 2037 | 51 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm049495j | ||
| 1566 | 2037 | 51 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm049495j | ||
| 28145931 | 2037 | 51 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm049495j | ||
| CHEMBL1201191 | 2037 | 51 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm049495j | ||
| DB06282 | 2037 | 51 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 10.1021/jm049495j | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1016/j.bmcl.2020.127681 | ||
| 12992629 | 122084 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 584 | 8 | 2 | 5 | 6.1 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL360202 | 122084 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 584 | 8 | 2 | 5 | 6.1 | NC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 21509921 | 103979 | 0 | None | -4 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL3104091 | 103979 | 0 | None | -4 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| 9870460 | 102386 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 496 | 7 | 2 | 5 | 3.8 | NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL305662 | 102386 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 496 | 7 | 2 | 5 | 3.8 | NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)O1 | 10.1016/j.bmcl.2004.02.005 | ||
| 71462100 | 80868 | 0 | None | -39 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158792 | 80868 | 0 | None | -39 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 502 | 8 | 1 | 4 | 5.4 | Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 10005242 | 80878 | 0 | None | -3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158819 | 80878 | 0 | None | -3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69347980 | 80892 | 1 | None | 5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158832 | 80892 | 1 | None | 5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072040 | 80895 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158835 | 80895 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 5.2 | O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072044 | 80897 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158837 | 80897 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 5.9 | O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072050 | 80899 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158839 | 80899 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71072118 | 80901 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158841 | 80901 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 8 | 1 | 4 | 5.4 | O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59295946 | 83599 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 612 | 11 | 5 | 8 | 1.7 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207281 | 83599 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 612 | 11 | 5 | 8 | 1.7 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295974 | 83688 | 0 | None | -19 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207672 | 83688 | 0 | None | -19 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 21509921 | 103979 | 0 | None | -4 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| CHEMBL3104091 | 103979 | 0 | None | -4 | 24 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2726 | 906 | 64 | None | -6 | 72 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
| 621 | 906 | 64 | None | -6 | 72 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
| 83 | 906 | 64 | None | -6 | 72 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
| CHEMBL71 | 906 | 64 | None | -6 | 72 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
| DB00477 | 906 | 64 | None | -6 | 72 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1021/jm070516u | ||
| 17963208 | 81841 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171034 | 81841 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963334 | 81845 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171038 | 81845 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 525 | 5 | 1 | 5 | 4.7 | Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 71457010 | 81846 | 0 | None | -10 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171039 | 81846 | 0 | None | -10 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 10143016 | 81861 | 0 | None | 3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171215 | 81861 | 0 | None | 3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 525 | 6 | 1 | 5 | 4.5 | O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 10947658 | 28490 | 0 | None | -457 | 16 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
| CHEMBL137781 | 28490 | 0 | None | -457 | 16 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | ||
| 9826801 | 107451 | 0 | None | -2187 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm100652h | ||
| CHEMBL319352 | 107451 | 0 | None | -2187 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 488 | 6 | 1 | 7 | 3.2 | Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 | 10.1021/jm100652h | ||
| 10414153 | 21339 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 515 | 6 | 2 | 7 | 5.5 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(n3c(O)nc4ccccc43)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL131648 | 21339 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 515 | 6 | 2 | 7 | 5.5 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(n3c(O)nc4ccccc43)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 14885641 | 114590 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 317 | 0 | 0 | 1 | 4.2 | CC(=O)N1CCC(=C2c3ccccc3CCc3ccccc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL334318 | 114590 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 317 | 0 | 0 | 1 | 4.2 | CC(=O)N1CCC(=C2c3ccccc3CCc3ccccc32)CC1 | 10.1021/jm00105a069 | ||
| 46882182 | 5844 | 0 | None | -95 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 567 | 11 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1 | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1079686 | 5844 | 0 | None | -95 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 567 | 11 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1 | 10.1016/j.bmcl.2009.09.024 | ||
| 168288633 | 191182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 712 | 18 | 5 | 7 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5198008 | 191182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 712 | 18 | 5 | 7 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304091 | 201262 | 0 | None | -63 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 432 | 14 | 0 | 5 | 5.2 | CCCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62949 | 201262 | 0 | None | -63 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 432 | 14 | 0 | 5 | 5.2 | CCCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335463 | 4389 | 0 | None | -8 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 357 | 7 | 1 | 4 | 3.2 | CCOC(=O)N1CCN(CCCOc2ccc(-c3cc[nH]c3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL101692 | 4389 | 0 | None | -8 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 357 | 7 | 1 | 4 | 3.2 | CCOC(=O)N1CCN(CCCOc2ccc(-c3cc[nH]c3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 66615606 | 80861 | 0 | None | -398 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 513 | 8 | 1 | 5 | 4.9 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158785 | 80861 | 0 | None | -398 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 513 | 8 | 1 | 5 | 4.9 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 50878551 | 90314 | 60 | None | -21 | 18 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| CHEMBL2391541 | 90314 | 60 | None | -21 | 18 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| 71459825 | 83785 | 0 | None | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208417 | 83785 | 0 | None | -3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmcl.2012.09.113 | ||
| 71452602 | 83804 | 0 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208436 | 83804 | 0 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 433 | 8 | 2 | 5 | 3.9 | N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296098 | 83684 | 0 | None | -15 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 446 | 7 | 3 | 6 | 2.0 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207668 | 83684 | 0 | None | -15 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 446 | 7 | 3 | 6 | 2.0 | N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2012.09.112 | ||
| 168288633 | 191182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 712 | 18 | 5 | 7 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5198008 | 191182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 712 | 18 | 5 | 7 | 2.5 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 18672441 | 94951 | 0 | None | -691 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 306 | 6 | 0 | 3 | 4.1 | N#Cc1ccc(-c2ccc(OCCCN3CCCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL25688 | 94951 | 0 | None | -691 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 306 | 6 | 0 | 3 | 4.1 | N#Cc1ccc(-c2ccc(OCCCN3CCCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168290815 | 192371 | 0 | None | -10232 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 327 | 9 | 4 | 5 | 1.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5200771 | 192371 | 0 | None | -10232 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 327 | 9 | 4 | 5 | 1.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222529 | 192371 | 0 | None | -10232 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 327 | 9 | 4 | 5 | 1.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 10802229 | 56262 | 0 | None | -794 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 273 | 6 | 2 | 3 | 2.8 | C[C@@H](NC(=O)OCCCc1c[nH]cn1)c1ccccc1 | 10.1021/jm9507688 | ||
| CHEMBL16401 | 56262 | 0 | None | -794 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 273 | 6 | 2 | 3 | 2.8 | C[C@@H](NC(=O)OCCCc1c[nH]cn1)c1ccccc1 | 10.1021/jm9507688 | ||
| 10729448 | 56270 | 0 | None | -1584 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 251 | 6 | 2 | 3 | 2.3 | O=C(NCC1CCCC1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16407 | 56270 | 0 | None | -1584 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 251 | 6 | 2 | 3 | 2.3 | O=C(NCC1CCCC1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10588560 | 96126 | 0 | None | -2089 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 277 | 6 | 2 | 3 | 2.4 | O=C(NCc1ccc(F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL263070 | 96126 | 0 | None | -2089 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 277 | 6 | 2 | 3 | 2.4 | O=C(NCc1ccc(F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10852027 | 98235 | 0 | None | -3890 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 304 | 7 | 2 | 5 | 2.2 | O=C(NCc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL277537 | 98235 | 0 | None | -3890 | 2 | Guinea pig | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 304 | 7 | 2 | 5 | 2.2 | O=C(NCc1cccc([N+](=O)[O-])c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 57345618 | 70116 | 0 | None | -7 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 362 | 6 | 0 | 3 | 4.5 | Fc1ccc(OCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946126 | 70116 | 0 | None | -7 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 362 | 6 | 0 | 3 | 4.5 | Fc1ccc(OCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 44582675 | 189109 | 0 | None | -8 | 15 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| CHEMBL515472 | 189109 | 0 | None | -8 | 15 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| 14554127 | 112826 | 0 | None | 3 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 380 | 2 | 0 | 2 | 5.1 | CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL331603 | 112826 | 0 | None | 3 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 380 | 2 | 0 | 2 | 5.1 | CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 10.1021/jm0002432 | ||
| 73346042 | 91402 | 3 | None | -5128 | 17 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 405 | 9 | 0 | 8 | 0.9 | Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O | 10.1016/j.bmc.2013.05.050 | ||
| CHEMBL2413153 | 91402 | 3 | None | -5128 | 17 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 405 | 9 | 0 | 8 | 0.9 | Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O | 10.1016/j.bmc.2013.05.050 | ||
| 168269172 | 189409 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 684 | 17 | 5 | 7 | 1.8 | C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5171289 | 189409 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 684 | 17 | 5 | 7 | 1.8 | C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168286426 | 192324 | 0 | None | -58 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 403 | 10 | 4 | 5 | 2.3 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5198795 | 192324 | 0 | None | -58 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 403 | 10 | 4 | 5 | 2.3 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222241 | 192324 | 0 | None | -58 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 403 | 10 | 4 | 5 | 2.3 | CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 164618508 | 185350 | 0 | None | -165 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 374 | 6 | 4 | 4 | 2.7 | Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4869194 | 185350 | 0 | None | -165 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 374 | 6 | 4 | 4 | 2.7 | Cc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 168269172 | 189409 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 684 | 17 | 5 | 7 | 1.8 | C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5171289 | 189409 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 684 | 17 | 5 | 7 | 1.8 | C[C@H](NC(=O)CNC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 83632 | 5109 | 6 | None | 1 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 225 | 4 | 0 | 1 | 3.4 | CN(C)CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL10602 | 5109 | 6 | None | 1 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 225 | 4 | 0 | 1 | 3.4 | CN(C)CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 60165413 | 75010 | 0 | None | -15 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.5 | O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
| CHEMBL2037531 | 75010 | 0 | None | -15 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.5 | O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1 | 10.1016/j.ejmech.2012.03.042 | ||
| 11848677 | 147820 | 0 | None | -1 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 8 | 2 | 8 | 3.0 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL393718 | 147820 | 0 | None | -1 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 8 | 2 | 8 | 3.0 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| 10341609 | 198586 | 0 | None | -117 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 11 | 1 | 5 | 3.4 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3c[nH]cn3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL59715 | 198586 | 0 | None | -117 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 412 | 11 | 1 | 5 | 3.4 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3c[nH]cn3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 168274129 | 192207 | 0 | None | -16 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 12 | 5 | 6 | 1.0 | NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5176780 | 192207 | 0 | None | -16 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 12 | 5 | 6 | 1.0 | NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221468 | 192207 | 0 | None | -16 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 370 | 12 | 5 | 6 | 1.0 | NCCCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168294770 | 192418 | 0 | None | -2 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5208327 | 192418 | 0 | None | -2 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222806 | 192418 | 0 | None | -2 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 436 | 6 | 4 | 4 | 4.3 | Cc1ccc(CC(C)CNC(=O)/N=C(\N)Nc2cccc(-c3sc(N)nc3C)c2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168295803 | 192443 | 0 | None | -3 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.6 | CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5207206 | 192443 | 0 | None | -3 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.6 | CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222937 | 192443 | 0 | None | -3 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 338 | 6 | 4 | 4 | 1.6 | CCCCCNC(=O)/N=C(\N)NCC1CCc2nc(N)sc2C1 | 10.1021/acs.jmedchem.1c00692 | ||
| 112936262 | 136752 | 1 | None | -3 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 3.5 | COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752195 | 136752 | 1 | None | -3 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 3.5 | COc1ccc(CNc2nc(-c3ccccc3)cc(N3CCN(C)CC3)n2)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| 164620139 | 185206 | 0 | None | -60 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 436 | 8 | 4 | 4 | 3.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4866734 | 185206 | 0 | None | -60 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 436 | 8 | 4 | 4 | 3.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 164608941 | 183801 | 0 | None | -123 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 390 | 7 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4845733 | 183801 | 0 | None | -123 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 390 | 7 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 3168 | 9172 | 84 | None | -87 | 21 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| CHEMBL1108 | 9172 | 84 | None | -87 | 21 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| 17590280 | 68681 | 6 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 264 | 4 | 1 | 2 | 3.5 | Cc1cccc2c(CCN)cn(Cc3ccccc3)c12 | 10.1021/jm2011589 | ||
| CHEMBL1923524 | 68681 | 6 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 264 | 4 | 1 | 2 | 3.5 | Cc1cccc2c(CCN)cn(Cc3ccccc3)c12 | 10.1021/jm2011589 | ||
| 168295528 | 192429 | 0 | None | -2951 | 20 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5206565 | 192429 | 0 | None | -2951 | 20 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222872 | 192429 | 0 | None | -2951 | 20 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 4440801 | 167721 | 9 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 298 | 3 | 1 | 6 | 1.5 | OCCN1CCN(c2ncnc3c2oc2ccccc23)CC1 | 10.1021/jm2011589 | ||
| CHEMBL434001 | 167721 | 9 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 298 | 3 | 1 | 6 | 1.5 | OCCN1CCN(c2ncnc3c2oc2ccccc23)CC1 | 10.1021/jm2011589 | ||
| 12016525 | 201226 | 0 | None | -2630 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 1.5 | C[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62804 | 201226 | 0 | None | -2630 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 1.5 | C[C@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 164611143 | 184133 | 0 | None | -234 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.9 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4850448 | 184133 | 0 | None | -234 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 414 | 6 | 4 | 4 | 2.9 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(c1ccccc1)C(F)(F)F | 10.1016/j.ejmech.2021.113190 | ||
| 9830741 | 206120 | 1 | None | -275 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 6 | 1 | 4 | 5.0 | C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 | 10.1021/jm000085e | ||
| CHEMBL96467 | 206120 | 1 | None | -275 | 7 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 6 | 1 | 4 | 5.0 | C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 | 10.1021/jm000085e | ||
| 122196373 | 123768 | 0 | None | -2 | 5 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 471 | 7 | 0 | 6 | 6.4 | Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1 | 10.1016/j.bmcl.2015.09.045 | ||
| CHEMBL3634813 | 123768 | 0 | None | -2 | 5 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 471 | 7 | 0 | 6 | 6.4 | Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1 | 10.1016/j.bmcl.2015.09.045 | ||
| 46929554 | 16575 | 0 | None | -31 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 4.7 | FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1 | 10.1021/jm100643t | ||
| CHEMBL1243367 | 16575 | 0 | None | -31 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 4.7 | FC(F)(F)c1ccc(SCC(c2ccncc2)c2c[nH]cn2)cc1 | 10.1021/jm100643t | ||
| 1854 | 3496 | 5 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 355 | 1 | 0 | 3 | 3.1 | Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1 | 10.1016/s0960-894x(98)00626-x | ||
| 9950564 | 3496 | 5 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 355 | 1 | 0 | 3 | 3.1 | Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL326821 | 3496 | 5 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 355 | 1 | 0 | 3 | 3.1 | Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1 | 10.1016/s0960-894x(98)00626-x | ||
| 141485889 | 170632 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 290 | 7 | 0 | 3 | 2.4 | CCN(CC)CCCOc1ccc2c(c1)C(=O)N(C)CC2 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4459304 | 170632 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 290 | 7 | 0 | 3 | 2.4 | CCN(CC)CCCOc1ccc2c(c1)C(=O)N(C)CC2 | 10.1016/j.bmcl.2019.04.015 | ||
| 9906447 | 193904 | 1 | None | -7585 | 13 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.8 | C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1 | 10.1021/jm201690h | ||
| CHEMBL2031738 | 193904 | 1 | None | -7585 | 13 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.8 | C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1 | 10.1021/jm201690h | ||
| CHEMBL555146 | 193904 | 1 | None | -7585 | 13 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 351 | 5 | 0 | 3 | 4.8 | C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1 | 10.1021/jm201690h | ||
| 25147772 | 172837 | 4 | None | -6 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 3.7 | CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL452847 | 172837 | 4 | None | -6 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 3.7 | CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 168274690 | 189944 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5179725 | 189944 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 71681209 | 89841 | 0 | None | -138 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 464 | 7 | 0 | 6 | 5.7 | Cc1c(C)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2oc1=O | 10.1021/jm400408r | ||
| CHEMBL2385102 | 89841 | 0 | None | -138 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 464 | 7 | 0 | 6 | 5.7 | Cc1c(C)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2oc1=O | 10.1021/jm400408r | ||
| 44304327 | 199198 | 0 | None | -1380 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 535 | 11 | 1 | 6 | 4.3 | CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60143 | 199198 | 0 | None | -1380 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 535 | 11 | 1 | 6 | 4.3 | CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 168268716 | 192160 | 0 | None | -1 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 372 | 3 | 4 | 4 | 3.5 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5170276 | 192160 | 0 | None | -1 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 372 | 3 | 4 | 4 | 3.5 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221176 | 192160 | 0 | None | -1 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 372 | 3 | 4 | 4 | 3.5 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NC2CCCCC2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168274690 | 189944 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5179725 | 189944 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 770 | 20 | 6 | 8 | 2.3 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 10051425 | 202960 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 494 | 7 | 2 | 5 | 4.0 | NC(=O)N(O)CCC#Cc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)o1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL73706 | 202960 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 494 | 7 | 2 | 5 | 4.0 | NC(=O)N(O)CCC#Cc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)o1 | 10.1016/j.bmcl.2004.02.005 | ||
| 44334782 | 5353 | 0 | None | -1318 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 442 | 10 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL107293 | 5353 | 0 | None | -1318 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 442 | 10 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 71457844 | 83662 | 0 | None | -2884 | 7 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| CHEMBL2207638 | 83662 | 0 | None | -2884 | 7 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 429 | 6 | 0 | 4 | 5.1 | COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| 73349359 | 92111 | 0 | None | -8 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 341 | 6 | 1 | 4 | 2.9 | COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC | 10.1016/j.bmc.2013.07.045 | ||
| CHEMBL2432051 | 92111 | 0 | None | -8 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 341 | 6 | 1 | 4 | 2.9 | COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC | 10.1016/j.bmc.2013.07.045 | ||
| 44591012 | 175007 | 0 | None | -114 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 522 | 10 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL457957 | 175007 | 0 | None | -114 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 522 | 10 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 44304439 | 102325 | 0 | None | -5 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 436 | 12 | 0 | 4 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL305338 | 102325 | 0 | None | -5 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 436 | 12 | 0 | 4 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)Cc3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304245 | 201637 | 0 | None | -13 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 425 | 11 | 0 | 5 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccn3C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64884 | 201637 | 0 | None | -13 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 425 | 11 | 0 | 5 | 4.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccn3C)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44334281 | 4691 | 0 | None | -181 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 433 | 9 | 2 | 6 | 2.8 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL103828 | 4691 | 0 | None | -181 | 3 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 433 | 9 | 2 | 6 | 2.8 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 168281024 | 190321 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 741 | 19 | 6 | 8 | 1.1 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185247 | 190321 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 741 | 19 | 6 | 8 | 1.1 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304459 | 172031 | 0 | None | -151 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 13 | 0 | 5 | 4.8 | CCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL449040 | 172031 | 0 | None | -151 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 13 | 0 | 5 | 4.8 | CCCCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304283 | 201483 | 0 | None | -42 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 452 | 8 | 0 | 5 | 4.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(C(C)(C)C)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64247 | 201483 | 0 | None | -42 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 452 | 8 | 0 | 5 | 4.8 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(C(C)(C)C)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 10472082 | 5072 | 0 | None | -831 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.9 | C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105762 | 5072 | 0 | None | -831 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 334 | 6 | 0 | 3 | 4.9 | C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(-c2ccc(C#N)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168281024 | 190321 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 741 | 19 | 6 | 8 | 1.1 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185247 | 190321 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 741 | 19 | 6 | 8 | 1.1 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 9923186 | 107056 | 0 | None | -288 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.1 | N#Cc1ccc(-c2ccc(OCCCN3CC[C@H](O)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL318801 | 107056 | 0 | None | -288 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.1 | N#Cc1ccc(-c2ccc(OCCCN3CC[C@H](O)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168273745 | 192206 | 0 | None | -114 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 332 | 6 | 4 | 4 | 1.5 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5178472 | 192206 | 0 | None | -114 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 332 | 6 | 4 | 4 | 1.5 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221451 | 192206 | 0 | None | -114 | 6 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 332 | 6 | 4 | 4 | 1.5 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 2435 | 3533 | 78 | None | -95 | 48 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
| 60149 | 3533 | 78 | None | -95 | 48 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
| 98 | 3533 | 78 | None | -95 | 48 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
| CHEMBL12713 | 3533 | 78 | None | -95 | 48 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
| DB06144 | 3533 | 78 | None | -95 | 48 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 10.1021/jm030480f | ||
| 44304399 | 201503 | 0 | None | -28 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 418 | 13 | 0 | 5 | 4.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCCCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64317 | 201503 | 0 | None | -28 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 418 | 13 | 0 | 5 | 4.8 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCCCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44335456 | 4485 | 0 | None | -18 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 6 | 1 | 4 | 3.5 | N#Cc1ccc(-c2ccc(OCCCN3CCC(O)CC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL102416 | 4485 | 0 | None | -18 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 6 | 1 | 4 | 3.5 | N#Cc1ccc(-c2ccc(OCCCN3CCC(O)CC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 127036978 | 136757 | 0 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 415 | 5 | 1 | 6 | 3.6 | COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752225 | 136757 | 0 | None | -1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 415 | 5 | 1 | 6 | 3.6 | COc1ccc(CNc2nc3c(c(N4CCN(C)CC4)n2)CCc2ccccc2-3)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm0205651 | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm0205651 | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm0205651 | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm0205651 | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 10.1021/jm0205651 | ||
| 10474964 | 129949 | 0 | None | -181 | 7 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 381 | 5 | 1 | 3 | 3.3 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| CHEMBL368061 | 129949 | 0 | None | -181 | 7 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 381 | 5 | 1 | 3 | 3.3 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| CHEMBL5206021 | 129949 | 0 | None | -181 | 7 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 381 | 5 | 1 | 3 | 3.3 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm950759z | ||
| 9827677 | 167858 | 0 | None | -288 | 7 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 7 | 2 | 4 | 4.2 | CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL43491 | 167858 | 0 | None | -288 | 7 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 7 | 2 | 4 | 4.2 | CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| 71212556 | 143030 | 0 | None | -7 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 433 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2 | nan | ||
| CHEMBL3899169 | 143030 | 0 | None | -7 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 433 | 3 | 1 | 6 | 4.6 | Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2 | nan | ||
| 51002362 | 82210 | 0 | None | 3 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 448 | 5 | 1 | 7 | 3.8 | COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1 | 10.1021/jm300955x | ||
| CHEMBL2179222 | 82210 | 0 | None | 3 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 448 | 5 | 1 | 7 | 3.8 | COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1 | 10.1021/jm300955x | ||
| 164618283 | 183961 | 0 | None | -158 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 390 | 7 | 4 | 5 | 2.4 | COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4848026 | 183961 | 0 | None | -158 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 390 | 7 | 4 | 5 | 2.4 | COc1ccc(C(C)NC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1 | 10.1016/j.ejmech.2021.113190 | ||
| 164614645 | 184549 | 0 | None | -57 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 402 | 8 | 4 | 4 | 3.0 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4856572 | 184549 | 0 | None | -57 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 402 | 8 | 4 | 4 | 3.0 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(c1ccccc1)C(C)C | 10.1016/j.ejmech.2021.113190 | ||
| 11530223 | 8065 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1cccc(C(C)c2c(CCN(C)C)sc3ccccc23)n1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091792 | 8065 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 340 | 6 | 0 | 4 | 4.6 | COc1cccc(C(C)c2c(CCN(C)C)sc3ccccc23)n1 | 10.1016/j.bmcl.2010.01.134 | ||
| 45273828 | 194161 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 374 | 4 | 0 | 4 | 4.9 | Fc1ccc(Cn2c(N3CCC(n4cccc4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL558339 | 194161 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 374 | 4 | 0 | 4 | 4.9 | Fc1ccc(Cn2c(N3CCC(n4cccc4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 10343536 | 4893 | 0 | None | -3715 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 446 | 10 | 1 | 5 | 3.2 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(F)c3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL104809 | 4893 | 0 | None | -3715 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 446 | 10 | 1 | 5 | 3.2 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3cccc(F)c3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 132060746 | 162520 | 0 | None | -3 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 405 | 4 | 0 | 4 | 4.4 | O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4176474 | 162520 | 0 | None | -3 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 405 | 4 | 0 | 4 | 4.4 | O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 | 10.1016/j.ejmech.2018.02.024 | ||
| 91864602 | 140207 | 0 | None | -169 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818047 | 140207 | 0 | None | -169 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 44301676 | 197518 | 0 | None | 8 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 396 | 11 | 1 | 3 | 5.3 | CN(CCCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL58973 | 197518 | 0 | None | 8 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 396 | 11 | 1 | 3 | 5.3 | CN(CCCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| 44326357 | 111119 | 0 | None | 2 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.9 | CN(C)CC1C[C@@H]2c3ccccc3N(C)c3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL328356 | 111119 | 0 | None | 2 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 308 | 2 | 0 | 3 | 3.9 | CN(C)CC1C[C@@H]2c3ccccc3N(C)c3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 5074 | 3280 | 75 | None | -11 | 29 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.1021/jm00112a025 | ||
| 97 | 3280 | 75 | None | -11 | 29 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.1021/jm00112a025 | ||
| CHEMBL267777 | 3280 | 75 | None | -11 | 29 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.1021/jm00112a025 | ||
| DB12693 | 3280 | 75 | None | -11 | 29 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.1021/jm00112a025 | ||
| 44521013 | 198111 | 0 | None | 13 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 251 | 3 | 0 | 1 | 3.7 | CN(C)CCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL593988 | 198111 | 0 | None | 13 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 251 | 3 | 0 | 1 | 3.7 | CN(C)CCC1c2ccccc2Cc2ccccc21 | 10.1016/j.bmc.2009.08.016 | ||
| 23722970 | 68678 | 20 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/jm2011589 | ||
| CHEMBL1923521 | 68678 | 20 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/jm2011589 | ||
| CHEMBL3977546 | 68678 | 20 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/jm2011589 | ||
| 135515431 | 4182 | 30 | None | 3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 328 | 1 | 2 | 6 | 2.6 | CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1 | 10.1016/S0960-894X(96)00567-7 | ||
| CHEMBL100454 | 4182 | 30 | None | 3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 328 | 1 | 2 | 6 | 2.6 | CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1 | 10.1016/S0960-894X(96)00567-7 | ||
| 15749430 | 102040 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 4.1 | CN(C)CCC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| CHEMBL304042 | 102040 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 4.1 | CN(C)CCC/C=C1\c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00089a020 | ||
| 69262172 | 80881 | 1 | None | -3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158822 | 80881 | 1 | None | -3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59296010 | 83799 | 0 | None | -3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 490 | 7 | 3 | 6 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208431 | 83799 | 0 | None | -3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 490 | 7 | 3 | 6 | 2.9 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295958 | 83598 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207280 | 83598 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 23722970 | 68678 | 20 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/jm2011589 | ||
| CHEMBL1923521 | 68678 | 20 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/jm2011589 | ||
| CHEMBL3977546 | 68678 | 20 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 4 | 1 | 2 | 3.4 | c1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/jm2011589 | ||
| 134132469 | 154024 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 301 | 4 | 1 | 2 | 4.1 | Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3910939 | 154024 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 301 | 4 | 1 | 2 | 4.1 | Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3991161 | 154024 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 301 | 4 | 1 | 2 | 4.1 | Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 134155595 | 154058 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 6 | 0 | 2 | 3.4 | c1ccc(Cc2ccccc2OCCN2CCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3962094 | 154058 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 6 | 0 | 2 | 3.4 | c1ccc(Cc2ccccc2OCCN2CCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3991444 | 154058 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 6 | 0 | 2 | 3.4 | c1ccc(Cc2ccccc2OCCN2CCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 135398745 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
| 47 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
| CHEMBL715 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
| DB00334 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1021/jm070516u | ||
| 11291 | 98340 | 21 | None | 4 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1021/jm00017a019 | ||
| CHEMBL278398 | 98340 | 21 | None | 4 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | 10.1021/jm00017a019 | ||
| 5255691 | 10911 | 1 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 313 | 1 | 1 | 3 | 2.8 | Clc1ccc2c(c1)CCc1cccnc1C2N1CCNCC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL117406 | 10911 | 1 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 313 | 1 | 1 | 3 | 2.8 | Clc1ccc2c(c1)CCc1cccnc1C2N1CCNCC1 | 10.1016/s0960-894x(98)00626-x | ||
| 44343920 | 12681 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 1 | 0 | 3 | 3.2 | CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL118807 | 12681 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 327 | 1 | 0 | 3 | 3.2 | CN1CCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 155554396 | 174045 | 0 | None | 158 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 304 | 5 | 0 | 4 | 1.4 | CN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4557586 | 174045 | 0 | None | 158 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 304 | 5 | 0 | 4 | 1.4 | CN1CCc2ccc(OCCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 45270339 | 193727 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 4 | 0 | 4 | 4.2 | O=C1CCCCN1C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL552026 | 193727 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 4 | 0 | 4 | 4.2 | O=C1CCCCN1C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 11393666 | 192384 | 0 | None | -16 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | ||
| CHEMBL5201983 | 192384 | 0 | None | -16 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | ||
| CHEMBL5222597 | 192384 | 0 | None | -16 | 19 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | ||
| 53322838 | 57457 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 5.2 | C[C@H](C1=C(CCN(C)Cc2cccs2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669419 | 57457 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 375 | 7 | 0 | 4 | 5.2 | C[C@H](C1=C(CCN(C)Cc2cccs2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 135398737 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.01.012 | ||
| 38 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.01.012 | ||
| 722 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.01.012 | ||
| CHEMBL42 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.01.012 | ||
| DB00363 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.ejmech.2014.01.012 | ||
| 45272895 | 193984 | 9 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 4.6 | Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL556450 | 193984 | 9 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 4.6 | Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2009.05.086 | ||
| 45272895 | 193984 | 9 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 4.6 | Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2010.03.027 | ||
| CHEMBL556450 | 193984 | 9 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 4.6 | Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1 | 10.1016/j.bmcl.2010.03.027 | ||
| 9980189 | 114728 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 431 | 5 | 1 | 4 | 5.2 | O=C(O)c1ccc2c(c1)C(SCCN1CCc3ccccc3C1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL334678 | 114728 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 431 | 5 | 1 | 4 | 5.2 | O=C(O)c1ccc2c(c1)C(SCCN1CCc3ccccc3C1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 44304402 | 199527 | 0 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 415 | 12 | 0 | 6 | 4.5 | CCCCCC(=O)c1ccc(OCCCN2CCN(Cc3nccs3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL60360 | 199527 | 0 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 415 | 12 | 0 | 6 | 4.5 | CCCCCC(=O)c1ccc(OCCCN2CCN(Cc3nccs3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 23562970 | 100446 | 0 | None | -10 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 8 | 2 | 3 | 3.8 | Clc1ccc(C(CCNCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL293895 | 100446 | 0 | None | -10 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 8 | 2 | 3 | 3.8 | Clc1ccc(C(CCNCCc2c[nH]cn2)c2ccccn2)cc1 | 10.1016/s0960-894x(03)00357-3 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.5b00516 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.5b00516 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.5b00516 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.5b00516 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.5b00516 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1021/acs.jmedchem.5b00516 | ||
| 10339767 | 52908 | 0 | None | -602 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.8 | Cn1c(=O)sc2cc(CCCCN3CCC(c4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL15986 | 52908 | 0 | None | -602 | 3 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.8 | Cn1c(=O)sc2cc(CCCCN3CCC(c4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 44333987 | 108062 | 0 | None | -66 | 3 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 433 | 9 | 2 | 6 | 2.8 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL320174 | 108062 | 0 | None | -66 | 3 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 433 | 9 | 2 | 6 | 2.8 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44304088 | 200700 | 0 | None | -23 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 402 | 8 | 0 | 5 | 4.0 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CCCCC3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL61070 | 200700 | 0 | None | -23 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 402 | 8 | 0 | 5 | 4.0 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)C3CCCCC3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 91864602 | 140207 | 0 | None | -169 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818047 | 140207 | 0 | None | -169 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 313 | 5 | 0 | 2 | 4.4 | O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 57400700 | 67536 | 0 | None | -83 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 470 | 8 | 1 | 6 | 3.4 | COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910380 | 67536 | 0 | None | -83 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 470 | 8 | 1 | 6 | 3.4 | COc1ccc(CN(CCN2CCN(C(=O)c3nc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 18539962 | 101661 | 0 | None | -223 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 318 | 10 | 1 | 4 | 3.1 | CCCCCC(=O)c1ccc(OCCCN2CCNCC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL302445 | 101661 | 0 | None | -223 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 318 | 10 | 1 | 4 | 3.1 | CCCCCC(=O)c1ccc(OCCCN2CCNCC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 168283321 | 192293 | 0 | None | -2 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 364 | 7 | 4 | 4 | 2.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5183015 | 192293 | 0 | None | -2 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 364 | 7 | 4 | 4 | 2.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222057 | 192293 | 0 | None | -2 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 364 | 7 | 4 | 4 | 2.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| 127052293 | 139708 | 1 | None | -131 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3805361 | 139708 | 1 | None | -131 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmcl.2020.127681 | ||
| 57399432 | 70121 | 0 | None | -2 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.5 | Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946254 | 70121 | 0 | None | -2 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.5 | Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 45485462 | 196009 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 8 | 1 | 2 | 6.6 | CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL571174 | 196009 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 8 | 1 | 2 | 6.6 | CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2009.07.047 | ||
| 29136870 | 68679 | 7 | None | 46 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 301 | 2 | 0 | 7 | 0.7 | CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1 | 10.1021/jm2011589 | ||
| CHEMBL1923522 | 68679 | 7 | None | 46 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 301 | 2 | 0 | 7 | 0.7 | CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1 | 10.1021/jm2011589 | ||
| 289 | 240 | 6 | None | -56 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 8 | 0 | 2 | 4.9 | CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C | 10.1021/jm100697g | ||
| 9948320 | 240 | 6 | None | -56 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 8 | 0 | 2 | 4.9 | CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C | 10.1021/jm100697g | ||
| CHEMBL1242950 | 240 | 6 | None | -56 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 8 | 0 | 2 | 4.9 | CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C | 10.1021/jm100697g | ||
| 44288877 | 168034 | 0 | None | -87 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 549 | 7 | 1 | 5 | 4.3 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL43594 | 168034 | 0 | None | -87 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 549 | 7 | 1 | 5 | 4.3 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C | 10.1016/s0960-894x(99)00696-4 | ||
| 44304031 | 100205 | 0 | None | -85 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 452 | 10 | 0 | 6 | 4.1 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3ccc(OC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL292275 | 100205 | 0 | None | -85 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 452 | 10 | 0 | 6 | 4.1 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)/C=C/c3ccc(OC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 164611342 | 184505 | 0 | None | -134 | 6 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 346 | 6 | 4 | 4 | 1.8 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4856005 | 184505 | 0 | None | -134 | 6 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 346 | 6 | 4 | 4 | 1.8 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 3041343 | 109311 | 4 | None | -10 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 377 | 6 | 1 | 3 | 3.4 | O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| CHEMBL3233067 | 109311 | 4 | None | -10 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 377 | 6 | 1 | 3 | 3.4 | O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.03.014 | ||
| 132060770 | 162089 | 0 | None | 5 | 10 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 3.5 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4169689 | 162089 | 0 | None | 5 | 10 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 3.5 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| 29136870 | 68679 | 7 | None | 46 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 301 | 2 | 0 | 7 | 0.7 | CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1 | 10.1021/jm2011589 | ||
| CHEMBL1923522 | 68679 | 7 | None | 46 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 301 | 2 | 0 | 7 | 0.7 | CN1CCN(c2nc(N3CCCC3)c3cnn(C)c3n2)CC1 | 10.1021/jm2011589 | ||
| 3069135 | 69821 | 2 | None | -8 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 314 | 6 | 0 | 3 | 3.4 | Fc1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL1940412 | 69821 | 2 | None | -8 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 314 | 6 | 0 | 3 | 3.4 | Fc1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| 44334042 | 162937 | 0 | None | -562 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 453 | 10 | 1 | 6 | 3.0 | N#Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL420108 | 162937 | 0 | None | -562 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 453 | 10 | 1 | 6 | 3.0 | N#Cc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)C1 | 10.1016/s0960-894x(02)00685-6 | ||
| 11848624 | 88716 | 0 | None | -15 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 381 | 7 | 1 | 6 | 4.3 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC | 10.1021/jm701143p | ||
| CHEMBL236587 | 88716 | 0 | None | -15 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 381 | 7 | 1 | 6 | 4.3 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC | 10.1021/jm701143p | ||
| 11848624 | 88716 | 0 | None | -15 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 381 | 7 | 1 | 6 | 4.3 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL236587 | 88716 | 0 | None | -15 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 381 | 7 | 1 | 6 | 4.3 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| 46884637 | 7642 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1088898 | 7642 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 293 | 5 | 0 | 3 | 3.3 | Cc1nccnc1CC1=C(CCN(C)C)Cc2ccccc21 | 10.1016/j.bmcl.2010.02.055 | ||
| 44288917 | 99791 | 0 | None | -34 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 7 | 2 | 4 | 4.0 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL288768 | 99791 | 0 | None | -34 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 7 | 2 | 4 | 4.0 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| 71072104 | 80851 | 0 | None | -15 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158775 | 80851 | 0 | None | -15 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71460416 | 80852 | 0 | None | -2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158776 | 80852 | 0 | None | -2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 520 | 9 | 1 | 5 | 5.3 | COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 66615617 | 80864 | 0 | None | -31 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158788 | 80864 | 0 | None | -31 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl | 10.1016/j.bmcl.2012.08.103 | ||
| 10151756 | 80874 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.1 | O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158815 | 80874 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.1 | O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 68846936 | 80875 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158816 | 80875 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69260851 | 80883 | 1 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158824 | 80883 | 1 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 69347719 | 80891 | 1 | None | -3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158831 | 80891 | 1 | None | -3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 59296039 | 83795 | 0 | None | -15 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 8 | 3 | 6 | 3.2 | COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208427 | 83795 | 0 | None | -15 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 8 | 3 | 6 | 3.2 | COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N | 10.1016/j.bmcl.2012.09.113 | ||
| 59296024 | 83595 | 0 | None | -9 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207277 | 83595 | 0 | None | -9 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 59295928 | 83601 | 0 | None | -63 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207283 | 83601 | 0 | None | -63 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 3.2 | Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl | 10.1016/j.bmcl.2012.09.112 | ||
| 43229249 | 140286 | 1 | None | -16 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 279 | 5 | 0 | 2 | 3.7 | O=C(CCCN1CCc2ccccc2C1)c1ccccc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818989 | 140286 | 1 | None | -16 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 279 | 5 | 0 | 2 | 3.7 | O=C(CCCN1CCc2ccccc2C1)c1ccccc1 | 10.1016/j.bmc.2016.05.053 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 134145497 | 148631 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 309 | 6 | 0 | 2 | 4.5 | c1ccc(Cc2ccccc2OCCN2CCCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3943575 | 148631 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 309 | 6 | 0 | 2 | 4.5 | c1ccc(Cc2ccccc2OCCN2CCCCCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 129103318 | 166760 | 0 | None | -870 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 475 | 7 | 0 | 5 | 5.0 | O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 | 10.1016/j.ejmech.2020.112709 | ||
| CHEMBL4293999 | 166760 | 0 | None | -870 | 14 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 475 | 7 | 0 | 5 | 5.0 | O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 | 10.1016/j.ejmech.2020.112709 | ||
| 129103318 | 166760 | 0 | None | -870 | 14 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 475 | 7 | 0 | 5 | 5.0 | O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 | 10.1021/acs.jmedchem.8b01096 | ||
| CHEMBL4293999 | 166760 | 0 | None | -870 | 14 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 475 | 7 | 0 | 5 | 5.0 | O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 | 10.1021/acs.jmedchem.8b01096 | ||
| 10263017 | 205729 | 2 | None | 1 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 223 | 10 | 2 | 2 | 3.0 | NCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm00002a008 | ||
| CHEMBL94249 | 205729 | 2 | None | 1 | 3 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 223 | 10 | 2 | 2 | 3.0 | NCCCCCCCCCCc1c[nH]cn1 | 10.1021/jm00002a008 | ||
| 127036982 | 136942 | 0 | None | 3 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 525 | 6 | 1 | 6 | 5.9 | COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753784 | 136942 | 0 | None | 3 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 525 | 6 | 1 | 6 | 5.9 | COc1ccc(CNc2nc(N3CCN(C)CC3)nc3c2CCc2ccccc2-3)cc1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2015.12.035 | ||
| 550981 | 68689 | 12 | None | -2 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 280 | 5 | 2 | 3 | 2.9 | OC(CNC1CC1)Cn1c2ccccc2c2ccccc21 | 10.1021/jm2011589 | ||
| CHEMBL1923533 | 68689 | 12 | None | -2 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 280 | 5 | 2 | 3 | 2.9 | OC(CNC1CC1)Cn1c2ccccc2c2ccccc21 | 10.1021/jm2011589 | ||
| 10805119 | 54317 | 0 | None | -3235 | 2 | Guinea pig | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.6 | O=C(Nc1cccc(C(F)(F)F)c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16108 | 54317 | 0 | None | -3235 | 2 | Guinea pig | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.6 | O=C(Nc1cccc(C(F)(F)F)c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10062176 | 55545 | 0 | None | -15488 | 2 | Guinea pig | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 279 | 5 | 2 | 3 | 3.2 | O=C(Nc1ccc(Cl)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16231 | 55545 | 0 | None | -15488 | 2 | Guinea pig | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 279 | 5 | 2 | 3 | 3.2 | O=C(Nc1ccc(Cl)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10612308 | 97759 | 0 | None | -6309 | 2 | Guinea pig | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 273 | 7 | 2 | 3 | 2.3 | O=C(NCCc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL274262 | 97759 | 0 | None | -6309 | 2 | Guinea pig | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 273 | 7 | 2 | 3 | 2.3 | O=C(NCCc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 164612760 | 184135 | 0 | None | -54 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 390 | 7 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4850490 | 184135 | 0 | None | -54 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 390 | 7 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)NC[C@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 13091273 | 181856 | 0 | None | -275 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL478617 | 181856 | 0 | None | -275 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL553327 | 181856 | 0 | None | -275 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 119812 | 198048 | 59 | None | 23 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 225 | 5 | 1 | 1 | 3.4 | CNCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL593494 | 198048 | 59 | None | 23 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 225 | 5 | 1 | 1 | 3.4 | CNCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 9932698 | 17727 | 0 | None | -354 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 435 | 6 | 2 | 4 | 3.4 | NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm100652h | ||
| CHEMBL1259172 | 17727 | 0 | None | -354 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 435 | 6 | 2 | 4 | 3.4 | NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm100652h | ||
| 52946023 | 17732 | 0 | None | -95 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 7 | 2 | 4 | 3.6 | CC(=O)NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm100652h | ||
| CHEMBL1259187 | 17732 | 0 | None | -95 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 7 | 2 | 4 | 3.6 | CC(=O)NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 | 10.1021/jm100652h | ||
| 45485529 | 196041 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 6 | 1 | 2 | 5.2 | Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL571391 | 196041 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 6 | 1 | 2 | 5.2 | Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2009.07.047 | ||
| 49841845 | 69396 | 0 | None | -1288 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 309 | 2 | 1 | 6 | 2.2 | CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1 | 10.1016/j.bmcl.2011.10.104 | ||
| CHEMBL1935573 | 69396 | 0 | None | -1288 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 309 | 2 | 1 | 6 | 2.2 | CN1CCN(c2nc(N)nc3cc(-c4ccco4)ccc23)CC1 | 10.1016/j.bmcl.2011.10.104 | ||
| 168294767 | 192417 | 0 | None | -3235 | 20 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5207281 | 192417 | 0 | None | -3235 | 20 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222802 | 192417 | 0 | None | -3235 | 20 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 71454294 | 83663 | 0 | None | -1412 | 7 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 431 | 6 | 0 | 5 | 4.0 | COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| CHEMBL2207639 | 83663 | 0 | None | -1412 | 7 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 431 | 6 | 0 | 5 | 4.0 | COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1 | 10.1016/j.bmcl.2012.09.064 | ||
| 6918107 | 77787 | 13 | None | -7 | 5 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 319 | 2 | 0 | 4 | 3.5 | Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O | 10.1021/jm00075a026 | ||
| CHEMBL2103778 | 77787 | 13 | None | -7 | 5 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 319 | 2 | 0 | 4 | 3.5 | Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O | 10.1021/jm00075a026 | ||
| 127052293 | 139708 | 1 | None | -131 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3805361 | 139708 | 1 | None | -131 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 15723 | 18353 | 106 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 267 | 3 | 2 | 2 | 2.9 | OC(c1ccccc1)(c1ccccc1)C1CCNCC1 | 10.1016/j.bmcl.2009.07.047 | ||
| CHEMBL127508 | 18353 | 106 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 267 | 3 | 2 | 2 | 2.9 | OC(c1ccccc1)(c1ccccc1)C1CCNCC1 | 10.1016/j.bmcl.2009.07.047 | ||
| 44312568 | 203065 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 498 | 7 | 2 | 5 | 3.4 | NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)O1 | 10.1016/j.bmcl.2004.02.005 | ||
| CHEMBL74779 | 203065 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 498 | 7 | 2 | 5 | 3.4 | NC(=O)N(O)CCC#C[C@@H]1CC[C@@H](CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)O1 | 10.1016/j.bmcl.2004.02.005 | ||
| 44304243 | 201509 | 0 | None | -48 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 374 | 13 | 0 | 4 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(CCCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64334 | 201509 | 0 | None | -48 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 374 | 13 | 0 | 4 | 4.6 | CCCCCC(=O)c1ccc(OCCCN2CCN(CCCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 10003483 | 4576 | 0 | None | -2454 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 442 | 10 | 1 | 5 | 3.4 | Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL103027 | 4576 | 0 | None | -2454 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 442 | 10 | 1 | 5 | 3.4 | Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1 | 10.1016/s0960-894x(02)00685-6 | ||
| 168294161 | 192404 | 0 | None | -3 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5204739 | 192404 | 0 | None | -3 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222742 | 192404 | 0 | None | -3 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 3.3 | CCCCCNC(=O)/N=C(\N)Nc1cccc(-c2sc(N)nc2C)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 57390694 | 70122 | 0 | None | -3 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 5.1 | Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946255 | 70122 | 0 | None | -3 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 385 | 5 | 0 | 4 | 5.1 | Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 44582705 | 186413 | 0 | None | -4 | 13 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 399 | 9 | 0 | 4 | 4.5 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| CHEMBL490632 | 186413 | 0 | None | -4 | 13 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 399 | 9 | 0 | 4 | 4.5 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| 3050372 | 69823 | 7 | None | -15 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 296 | 6 | 0 | 3 | 3.3 | c1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL1940414 | 69823 | 7 | None | -15 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 296 | 6 | 0 | 3 | 3.3 | c1ccc(OCCCN2CCN(c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| 127036186 | 136889 | 0 | None | -21 | 19 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| CHEMBL3753318 | 136889 | 0 | None | -21 | 19 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| 44304494 | 201303 | 0 | None | -5495 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 489 | 12 | 1 | 6 | 4.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL63125 | 201303 | 0 | None | -5495 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 489 | 12 | 1 | 6 | 4.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 127049856 | 139715 | 0 | None | -23 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3805431 | 139715 | 0 | None | -23 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@H]1CC[C@@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 43229249 | 140286 | 1 | None | -16 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 279 | 5 | 0 | 2 | 3.7 | O=C(CCCN1CCc2ccccc2C1)c1ccccc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818989 | 140286 | 1 | None | -16 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 279 | 5 | 0 | 2 | 3.7 | O=C(CCCN1CCc2ccccc2C1)c1ccccc1 | 10.1016/j.bmc.2016.05.053 | ||
| 71457264 | 82209 | 0 | None | -2 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 447 | 5 | 1 | 6 | 4.4 | COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1 | 10.1021/jm300955x | ||
| CHEMBL2179217 | 82209 | 0 | None | -2 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 447 | 5 | 1 | 6 | 4.4 | COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1 | 10.1021/jm300955x | ||
| 122065 | 188958 | 3 | None | -1380 | 8 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 380 | 5 | 1 | 6 | 1.5 | COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 | 10.1021/jm970159v | ||
| CHEMBL51433 | 188958 | 3 | None | -1380 | 8 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 380 | 5 | 1 | 6 | 1.5 | COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 | 10.1021/jm970159v | ||
| 44591098 | 176188 | 0 | None | -199 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 508 | 9 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL460402 | 176188 | 0 | None | -199 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 508 | 9 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 162651034 | 179725 | 0 | None | -301 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 435 | 8 | 0 | 5 | 4.6 | O=C(c1ccc(Cl)cc1)c1ccc(OCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4750996 | 179725 | 0 | None | -301 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 435 | 8 | 0 | 5 | 4.6 | O=C(c1ccc(Cl)cc1)c1ccc(OCCCN2CCN(c3ccncc3)CC2)cc1 | 10.1016/j.ejmech.2020.113041 | ||
| 11681378 | 8185 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092496 | 8185 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1ccc(C(C)c2c(CCN(C)C)sc3ccccc23)cn1 | 10.1016/j.bmcl.2010.01.134 | ||
| 56944383 | 111627 | 0 | None | -125 | 12 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | ||
| CHEMBL3290012 | 111627 | 0 | None | -125 | 12 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 487 | 8 | 1 | 6 | 5.1 | O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1 | 10.1021/jm401895u | ||
| 10104 | 3510 | 7 | None | -2 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C | 10.1021/jm020895l | ||
| 6604866 | 3510 | 7 | None | -2 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C | 10.1021/jm020895l | ||
| CHEMBL1493369 | 3510 | 7 | None | -2 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 292 | 5 | 0 | 2 | 4.1 | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C | 10.1021/jm020895l | ||
| 168286548 | 190795 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 792 | 20 | 6 | 8 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192441 | 190795 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 792 | 20 | 6 | 8 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 1258 | 194 | 8 | None | -34673 | 5 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 1.5 | C[C@H](C(=O)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1)N | 10.1016/s0960-894x(02)00310-4 | ||
| 9906860 | 194 | 8 | None | -34673 | 5 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 1.5 | C[C@H](C(=O)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1)N | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL302196 | 194 | 8 | None | -34673 | 5 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 1.5 | C[C@H](C(=O)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1)N | 10.1016/s0960-894x(02)00310-4 | ||
| 168286548 | 190795 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 792 | 20 | 6 | 8 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5192441 | 190795 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 792 | 20 | 6 | 8 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 21527771 | 69813 | 0 | None | -275 | 10 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL1940404 | 69813 | 0 | None | -275 | 10 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | ||
| 56966475 | 104983 | 0 | None | -3467 | 4 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 448 | 8 | 0 | 6 | 4.3 | COc1ccccc1N1CCN(CCCCOc2ccc3c4c(c(=O)oc3c2)CCC4)CC1 | 10.1016/j.ejmech.2014.01.012 | ||
| CHEMBL3120682 | 104983 | 0 | None | -3467 | 4 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 448 | 8 | 0 | 6 | 4.3 | COc1ccccc1N1CCN(CCCCOc2ccc3c4c(c(=O)oc3c2)CCC4)CC1 | 10.1016/j.ejmech.2014.01.012 | ||
| 10177985 | 100189 | 0 | None | -1 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 382 | 10 | 1 | 3 | 4.9 | CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL292195 | 100189 | 0 | None | -1 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 382 | 10 | 1 | 3 | 4.9 | CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2020.127681 | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2020.127681 | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/j.bmcl.2020.127681 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 10.1021/jm1013874 | ||
| 10177985 | 100189 | 0 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 382 | 10 | 1 | 3 | 4.9 | CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1021/jm100064d | ||
| CHEMBL292195 | 100189 | 0 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 382 | 10 | 1 | 3 | 4.9 | CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1021/jm100064d | ||
| 15288693 | 52578 | 0 | None | 4 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 5 | 0 | 5 | 3.0 | Cn1c(=O)sc2cc(CCN3CCN(Cc4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL15955 | 52578 | 0 | None | 4 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 5 | 0 | 5 | 3.0 | Cn1c(=O)sc2cc(CCN3CCN(Cc4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/S0960-894X(96)00567-7 | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/S0960-894X(96)00567-7 | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/S0960-894X(96)00567-7 | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1016/S0960-894X(96)00567-7 | ||
| 10177985 | 100189 | 0 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 382 | 10 | 1 | 3 | 4.9 | CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1021/jm058225d | ||
| CHEMBL292195 | 100189 | 0 | None | 1 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 382 | 10 | 1 | 3 | 4.9 | CN(CCCCc1c[nH]cn1)CCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1021/jm058225d | ||
| 57402472 | 67537 | 0 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 6 | 4.0 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910381 | 67537 | 0 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 6 | 4.0 | COc1ccc(CN(CCN(C)CCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 45271166 | 194742 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 401 | 5 | 0 | 6 | 4.4 | COc1ccc(Cn2c(N3CCC(n4cc(C)cn4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL562894 | 194742 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 401 | 5 | 0 | 6 | 4.4 | COc1ccc(Cn2c(N3CCC(n4cc(C)cn4)CC3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2009.05.086 | ||
| 9819674 | 12825 | 0 | None | 1 | 5 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 347 | 3 | 1 | 5 | 2.4 | OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| CHEMBL118919 | 12825 | 0 | None | 1 | 5 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 347 | 3 | 1 | 5 | 2.4 | OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1 | 10.1021/jm010982y | ||
| 53320177 | 57442 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 293 | 6 | 0 | 3 | 3.4 | CCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669405 | 57442 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 293 | 6 | 0 | 3 | 3.4 | CCN(C)CCC1=C(Cc2cnccn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.12.053 | ||
| 10969390 | 59365 | 0 | None | 4 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 324 | 7 | 0 | 2 | 4.5 | CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| CHEMBL172233 | 59365 | 0 | None | 4 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 324 | 7 | 0 | 2 | 4.5 | CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1 | 10.1021/jm020895l | ||
| 44401041 | 70143 | 0 | None | -1 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 313 | 2 | 0 | 3 | 4.1 | CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| CHEMBL194659 | 70143 | 0 | None | -1 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 313 | 2 | 0 | 3 | 4.1 | CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1 | 10.1021/jm049632c | ||
| 10070478 | 13355 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1ccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cn1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL1193187 | 13355 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1ccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)cn1 | 10.1021/acs.jmedchem.9b00447 | ||
| 44389301 | 63980 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 619 | 13 | 1 | 6 | 6.8 | CC(C)COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL181085 | 63980 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 619 | 13 | 1 | 6 | 6.8 | CC(C)COC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 44305842 | 201708 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 4.1 | O=C(O)c1ccc2c(c1)/C(=C\CCN1CCSCC1)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| CHEMBL65492 | 201708 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 381 | 4 | 1 | 4 | 4.1 | O=C(O)c1ccc2c(c1)/C(=C\CCN1CCSCC1)c1ccccc1CO2 | 10.1021/jm00089a020 | ||
| 46884640 | 7831 | 0 | None | 2187 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cccnn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1090197 | 7831 | 0 | None | 2187 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 279 | 5 | 0 | 3 | 3.0 | CN(C)CCC1=C(Cc2cccnn2)c2ccccc2C1 | 10.1016/j.bmcl.2010.02.055 | ||
| 11846300 | 79856 | 3 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1021/jm800876b | ||
| CHEMBL213912 | 79856 | 3 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1021/jm800876b | ||
| 11846300 | 79856 | 3 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1021/jm051008s | ||
| CHEMBL213912 | 79856 | 3 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1021/jm051008s | ||
| 59295931 | 83797 | 0 | None | -5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 462 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208429 | 83797 | 0 | None | -5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 462 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 59295935 | 83596 | 0 | None | -3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207278 | 83596 | 0 | None | -3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 507 | 7 | 3 | 5 | 3.6 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 | 10.1016/j.bmcl.2012.09.112 | ||
| 10408773 | 164747 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 2 | 0 | 3 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncc2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL423316 | 164747 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 401 | 2 | 0 | 3 | 5.3 | Clc1ccc2c(c1)CCc1cccnc1C2=C1CCN(Cc2ccncc2)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 155527187 | 170586 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 414 | 2 | 0 | 2 | 6.2 | Cc1cccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL4458676 | 170586 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 414 | 2 | 0 | 2 | 6.2 | Cc1cccc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1 | 10.1021/acs.jmedchem.9b00447 | ||
| 134156988 | 153982 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 281 | 7 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCCN2CCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3984221 | 153982 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 281 | 7 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCCN2CCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| CHEMBL3990754 | 153982 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 281 | 7 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCCN2CCC2)cc1 | 10.1021/acs.jmedchem.6b00981 | ||
| 135398737 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
| 38 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
| 722 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
| CHEMBL42 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
| DB00363 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm070516u | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm070516u | ||
| 22397436 | 81825 | 0 | None | 6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 510 | 5 | 0 | 5 | 4.5 | CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171019 | 81825 | 0 | None | 6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 510 | 5 | 0 | 5 | 4.5 | CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 17963183 | 81850 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171043 | 81850 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 545 | 5 | 1 | 5 | 5.1 | O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.124 | ||
| 44267108 | 97893 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 366 | 0 | 0 | 2 | 4.6 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL275109 | 97893 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 366 | 0 | 0 | 2 | 4.6 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 120445 | 200379 | 4 | None | 16 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 253 | 6 | 0 | 1 | 4.2 | CN(C)CCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL608689 | 200379 | 4 | None | 16 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 253 | 6 | 0 | 1 | 4.2 | CN(C)CCCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 9998826 | 119971 | 0 | None | -69 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.1 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1 | 10.1021/jm950759z | ||
| CHEMBL354210 | 119971 | 0 | None | -69 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 3.1 | O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1 | 10.1021/jm950759z | ||
| 44266960 | 96708 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 380 | 1 | 0 | 3 | 4.1 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C=O)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| CHEMBL268022 | 96708 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 380 | 1 | 0 | 3 | 4.1 | CC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(C=O)cnc32)CC1 | 10.1016/S0960-894X(00)80290-5 | ||
| 69082816 | 74588 | 0 | None | -4168 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 431 | 5 | 0 | 3 | 4.1 | C[C@H]1CCCN1C(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1 | 10.1021/jm300011d | ||
| CHEMBL2031877 | 74588 | 0 | None | -4168 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 431 | 5 | 0 | 3 | 4.1 | C[C@H]1CCCN1C(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1 | 10.1021/jm300011d | ||
| 145986752 | 166723 | 0 | None | -16 | 17 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 562 | 10 | 1 | 5 | 7.3 | COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 | 10.1016/j.bmcl.2018.10.036 | ||
| CHEMBL4293307 | 166723 | 0 | None | -16 | 17 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 562 | 10 | 1 | 5 | 7.3 | COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 | 10.1016/j.bmcl.2018.10.036 | ||
| 56963799 | 74546 | 0 | None | -17782 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 378 | 6 | 0 | 5 | 4.6 | C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1 | 10.1021/jm201690h | ||
| CHEMBL2031737 | 74546 | 0 | None | -17782 | 10 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 378 | 6 | 0 | 5 | 4.6 | C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1 | 10.1021/jm201690h | ||
| 141485893 | 175165 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 317 | 5 | 0 | 4 | 1.3 | CN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1 | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4583068 | 175165 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 317 | 5 | 0 | 4 | 1.3 | CN1CCN(CCCOc2ccc3c(c2)C(=O)N(C)CC3)CC1 | 10.1016/j.bmcl.2019.04.015 | ||
| 45833388 | 68682 | 6 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 274 | 4 | 0 | 7 | 1.3 | CN(C)CCSc1nc2ccccc2c2nnnn12 | 10.1021/jm2011589 | ||
| CHEMBL1923525 | 68682 | 6 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 274 | 4 | 0 | 7 | 1.3 | CN(C)CCSc1nc2ccccc2c2nnnn12 | 10.1021/jm2011589 | ||
| 2537688 | 68683 | 3 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 264 | 3 | 1 | 6 | 0.8 | OCCN1CCN(c2ncnc3sccc23)CC1 | 10.1021/jm2011589 | ||
| CHEMBL1923526 | 68683 | 3 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 264 | 3 | 1 | 6 | 0.8 | OCCN1CCN(c2ncnc3sccc23)CC1 | 10.1021/jm2011589 | ||
| 168294776 | 192424 | 0 | None | -11 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 366 | 7 | 3 | 4 | 2.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5209479 | 192424 | 0 | None | -11 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 366 | 7 | 3 | 4 | 2.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222831 | 192424 | 0 | None | -11 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 366 | 7 | 3 | 4 | 2.6 | Cc1nnc(CCCN/C(N)=N/C(=O)NCC(C)C2CCCCC2)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 164609017 | 183843 | 0 | None | -125 | 6 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 416 | 10 | 4 | 4 | 3.2 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4846201 | 183843 | 0 | None | -125 | 6 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 416 | 10 | 4 | 4 | 3.2 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44304211 | 101727 | 0 | None | -6918 | 3 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.9 | CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL302829 | 101727 | 0 | None | -6918 | 3 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 373 | 9 | 1 | 5 | 1.9 | CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 129103313 | 166200 | 0 | None | -70 | 6 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 447 | 6 | 0 | 4 | 5.0 | O=C1CCc2cc(CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3 | 10.1021/acs.jmedchem.8b01096 | ||
| CHEMBL4283548 | 166200 | 0 | None | -70 | 6 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 447 | 6 | 0 | 4 | 5.0 | O=C1CCc2cc(CCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc3c2N1CC3 | 10.1021/acs.jmedchem.8b01096 | ||
| 145980875 | 166154 | 0 | None | -5 | 11 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| CHEMBL4282702 | 166154 | 0 | None | -5 | 11 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| 145992489 | 166424 | 0 | None | -2 | 12 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 535 | 7 | 1 | 2 | 7.8 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| CHEMBL4287623 | 166424 | 0 | None | -2 | 12 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 535 | 7 | 1 | 2 | 7.8 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| 95104704 | 161589 | 1 | None | 2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 344 | 6 | 1 | 4 | 3.1 | CCOc1ccc([C@H](O)CN2CCN(c3ccccc3F)CC2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| CHEMBL4161676 | 161589 | 1 | None | 2 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 344 | 6 | 1 | 4 | 3.1 | CCOc1ccc([C@H](O)CN2CCN(c3ccccc3F)CC2)cc1 | 10.1021/acs.jmedchem.8b00718 | ||
| 14885628 | 118929 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 336 | 0 | 0 | 2 | 3.8 | CC(=O)N1CCC(=C2c3ccc(F)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL344942 | 118929 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 336 | 0 | 0 | 2 | 3.8 | CC(=O)N1CCC(=C2c3ccc(F)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 25216680 | 74595 | 0 | None | -7244 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 3.6 | CCNC(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCC[C@H]2C)C3=O)cc1 | 10.1021/jm300011d | ||
| CHEMBL2031884 | 74595 | 0 | None | -7244 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 3.6 | CCNC(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCC[C@H]2C)C3=O)cc1 | 10.1021/jm300011d | ||
| 44304378 | 162721 | 0 | None | -35 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 11 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccnc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL418658 | 162721 | 0 | None | -35 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 11 | 0 | 5 | 4.1 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccnc3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 56852956 | 111551 | 1 | None | -186 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
| CHEMBL3289656 | 111551 | 1 | None | -186 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
| 168277996 | 192244 | 0 | None | -60 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5173373 | 192244 | 0 | None | -60 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221736 | 192244 | 0 | None | -60 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 380 | 4 | 4 | 4 | 3.3 | Cc1nc(N)sc1-c1cccc(N/C(N)=N/C(=O)NCc2ccccc2)c1 | 10.1021/acs.jmedchem.1c00692 | ||
| 46216771 | 200479 | 0 | None | -3 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 6 | 1 | 1 | 4.9 | c1ccc(CCCNCC2c3ccccc3Cc3ccccc32)cc1 | 10.1016/j.bmcl.2009.12.064 | ||
| CHEMBL609328 | 200479 | 0 | None | -3 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 6 | 1 | 1 | 4.9 | c1ccc(CCCNCC2c3ccccc3Cc3ccccc32)cc1 | 10.1016/j.bmcl.2009.12.064 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm030480f | ||
| 56852956 | 111551 | 1 | None | -186 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
| CHEMBL3289656 | 111551 | 1 | None | -186 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 2.8 | c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | ||
| 49841719 | 69394 | 0 | None | -1513 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 309 | 2 | 1 | 6 | 2.2 | CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1 | 10.1016/j.bmcl.2011.10.104 | ||
| CHEMBL1935571 | 69394 | 0 | None | -1513 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 309 | 2 | 1 | 6 | 2.2 | CN1CCN(c2nc(N)nc3cc(-c4ccoc4)ccc23)CC1 | 10.1016/j.bmcl.2011.10.104 | ||
| 127051015 | 140343 | 0 | None | -27 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818128 | 140343 | 0 | None | -27 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819731 | 140343 | 0 | None | -27 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 16655023 | 106955 | 1 | None | -60 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 3.7 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 | 10.1016/j.bmc.2007.03.053 | ||
| CHEMBL318235 | 106955 | 1 | None | -60 | 7 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 3.7 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 | 10.1016/j.bmc.2007.03.053 | ||
| 44304287 | 201209 | 0 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 428 | 11 | 0 | 5 | 4.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccs3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL62726 | 201209 | 0 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 428 | 11 | 0 | 5 | 4.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3cccs3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 132356 | 14508 | 1 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL1205688 | 14508 | 1 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL133778 | 14508 | 1 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 44333988 | 4467 | 0 | None | -199 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 8 | 1 | 5 | 2.6 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cccnc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL102331 | 4467 | 0 | None | -199 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 8 | 1 | 5 | 2.6 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)c3cccnc3)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44304037 | 102220 | 0 | None | -204 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 362 | 9 | 0 | 5 | 3.2 | CCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL304714 | 102220 | 0 | None | -204 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 362 | 9 | 0 | 5 | 3.2 | CCCC(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 127051015 | 140343 | 0 | None | -27 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818128 | 140343 | 0 | None | -27 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819731 | 140343 | 0 | None | -27 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 283 | 5 | 0 | 1 | 4.2 | Fc1ccc(CCCCN2CCc3ccccc3C2)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 24759623 | 95902 | 16 | None | -18 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 318 | 3 | 0 | 4 | 3.0 | CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1 | 10.1021/jm7014217 | ||
| CHEMBL261551 | 95902 | 16 | None | -18 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 318 | 3 | 0 | 4 | 3.0 | CN1CCN(c2nc3ccccc3nc2Cc2ccccc2)CC1 | 10.1021/jm7014217 | ||
| 168294449 | 192416 | 0 | None | -74 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 7 | 4 | 5 | 1.9 | CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5204599 | 192416 | 0 | None | -74 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 7 | 4 | 5 | 1.9 | CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222793 | 192416 | 0 | None | -74 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 367 | 7 | 4 | 5 | 1.9 | CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1 | 10.1021/acs.jmedchem.1c00692 | ||
| 162646011 | 179155 | 0 | None | -109 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.8 | c1ccc2cc(OCCCN3CCN(c4ccncc4)CC3)ccc2c1 | 10.1016/j.ejmech.2020.113041 | ||
| CHEMBL4744110 | 179155 | 0 | None | -109 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 347 | 6 | 0 | 4 | 3.8 | c1ccc2cc(OCCCN3CCN(c4ccncc4)CC3)ccc2c1 | 10.1016/j.ejmech.2020.113041 | ||
| 151221 | 200708 | 9 | None | 21 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 239 | 5 | 0 | 1 | 3.8 | CN(C)CCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| CHEMBL610739 | 200708 | 9 | None | 21 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 239 | 5 | 0 | 1 | 3.8 | CN(C)CCC(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2009.08.016 | ||
| 11659397 | 193612 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 297 | 5 | 0 | 4 | 3.4 | CN(C)CCc1sc2ccccc2c1Cc1cnccn1 | 10.1021/jm900933k | ||
| CHEMBL551340 | 193612 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 297 | 5 | 0 | 4 | 3.4 | CN(C)CCc1sc2ccccc2c1Cc1cnccn1 | 10.1021/jm900933k | ||
| 45267774 | 194533 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 416 | 5 | 0 | 6 | 4.1 | CN(c1ncccn1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| CHEMBL561489 | 194533 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 416 | 5 | 0 | 6 | 4.1 | CN(c1ncccn1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2009.05.086 | ||
| 44334556 | 106783 | 0 | None | -128 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 449 | 10 | 3 | 7 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL316968 | 106783 | 0 | None | -128 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 449 | 10 | 3 | 7 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@H](CO)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44335172 | 5028 | 0 | None | -3 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 374 | 7 | 0 | 5 | 4.0 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccsc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105567 | 5028 | 0 | None | -3 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 374 | 7 | 0 | 5 | 4.0 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccsc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168286141 | 192322 | 0 | None | -3 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5192993 | 192322 | 0 | None | -3 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222231 | 192322 | 0 | None | -3 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 450 | 8 | 4 | 4 | 4.8 | Cc1nc(N)sc1-c1ccc(N/C(N)=N/C(=O)NCC(C)CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 29298 | 201758 | 1 | None | -794 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 3.9 | CN(C)CCCNc1c2c(nc3ccccc13)CCCCC2 | 10.1016/s0960-894x(03)00356-1 | ||
| CHEMBL65849 | 201758 | 1 | None | -794 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 3.9 | CN(C)CCCNc1c2c(nc3ccccc13)CCCCC2 | 10.1016/s0960-894x(03)00356-1 | ||
| 57390224 | 67535 | 0 | None | -38 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.7 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| CHEMBL1910379 | 67535 | 0 | None | -38 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.7 | COc1ccc(CN(CCN2CCN(C(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c2ccccn2)cc1 | 10.1016/j.bmcl.2011.09.001 | ||
| 44335483 | 5221 | 0 | None | -257 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 336 | 6 | 1 | 4 | 3.5 | N#Cc1ccc(-c2ccc(OCCCN3CCCC(O)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL106596 | 5221 | 0 | None | -257 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 336 | 6 | 1 | 4 | 3.5 | N#Cc1ccc(-c2ccc(OCCCN3CCCC(O)C3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 164614549 | 184360 | 0 | None | -549 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 340 | 9 | 4 | 4 | 2.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4853668 | 184360 | 0 | None | -549 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 340 | 9 | 4 | 4 | 2.2 | CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1016/j.ejmech.2021.113190 | ||
| 164626153 | 185796 | 0 | None | -3801 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 378 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4875600 | 185796 | 0 | None | -3801 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 378 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1 | 10.1016/j.ejmech.2021.113190 | ||
| 164611807 | 184401 | 0 | None | -229 | 4 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 376 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4854278 | 184401 | 0 | None | -229 | 4 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 376 | 6 | 4 | 4 | 2.5 | Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44207909 | 16520 | 1 | None | -2 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 407 | 7 | 1 | 4 | 2.6 | O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1 | 10.1021/jm100697g | ||
| CHEMBL1242923 | 16520 | 1 | None | -2 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 407 | 7 | 1 | 4 | 2.6 | O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1 | 10.1021/jm100697g | ||
| 10403711 | 95886 | 27 | None | -4168 | 9 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 320 | 3 | 4 | 9 | -1.7 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.8b01662 | ||
| CHEMBL261482 | 95886 | 27 | None | -4168 | 9 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 320 | 3 | 4 | 9 | -1.7 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.8b01662 | ||
| 44591099 | 175616 | 0 | None | -295 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| CHEMBL459350 | 175616 | 0 | None | -295 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | ||
| 44304259 | 100148 | 0 | None | -2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 462 | 11 | 0 | 5 | 5.4 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3sccc3Cl)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL291882 | 100148 | 0 | None | -2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 462 | 11 | 0 | 5 | 5.4 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3sccc3Cl)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 71072113 | 80850 | 0 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158774 | 80850 | 0 | None | -3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 | 10.1016/j.bmcl.2012.08.103 | ||
| 66615678 | 80856 | 0 | None | -19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158780 | 80856 | 0 | None | -19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 488 | 8 | 1 | 4 | 5.0 | Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 66615702 | 80863 | 0 | None | -100 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.8 | C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158787 | 80863 | 0 | None | -100 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 522 | 8 | 1 | 4 | 5.8 | C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 71456722 | 80869 | 0 | None | -39 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 486 | 8 | 1 | 4 | 4.9 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| CHEMBL2158793 | 80869 | 0 | None | -39 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 486 | 8 | 1 | 4 | 4.9 | Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 | 10.1016/j.bmcl.2012.08.103 | ||
| 127026052 | 137028 | 0 | None | -4 | 19 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 258 | 7 | 1 | 1 | 3.5 | C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| CHEMBL3754496 | 137028 | 0 | None | -4 | 19 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 258 | 7 | 1 | 1 | 3.5 | C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 | 10.1016/j.bmcl.2015.12.053 | ||
| 59296073 | 83790 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.0 | N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208422 | 83790 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 483 | 8 | 2 | 6 | 3.0 | N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 | 10.1016/j.bmcl.2012.09.113 | ||
| 59296077 | 83594 | 0 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| CHEMBL2207276 | 83594 | 0 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 547 | 8 | 3 | 7 | 2.5 | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 | 10.1016/j.bmcl.2012.09.112 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 10.1038/nchembio714 | ||
| 71449858 | 81834 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 4.8 | O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| CHEMBL2171027 | 81834 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 4.8 | O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 | 10.1016/j.bmcl.2012.08.124 | ||
| 11515125 | 8060 | 0 | None | - | 1 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1091778 | 8060 | 0 | None | - | 1 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 310 | 5 | 0 | 3 | 4.6 | C[C@@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 127049855 | 139698 | 0 | None | -13 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3805220 | 139698 | 0 | None | -13 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 368 | 7 | 3 | 4 | 3.1 | N#C/N=C(/NCCSc1ccccc1)NC[C@@H]1CC[C@@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 168282610 | 190322 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 802 | 20 | 5 | 7 | 4.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185281 | 190322 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 802 | 20 | 5 | 7 | 4.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 2199935 | 118710 | 13 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 215 | 5 | 1 | 2 | 2.8 | CNCCCOc1cccc2ccccc12 | 10.1021/jm2011589 | ||
| CHEMBL343324 | 118710 | 13 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 215 | 5 | 1 | 2 | 2.8 | CNCCCOc1cccc2ccccc12 | 10.1021/jm2011589 | ||
| 168282610 | 190322 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 802 | 20 | 5 | 7 | 4.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5185281 | 190322 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 802 | 20 | 5 | 7 | 4.1 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 10517956 | 55962 | 0 | None | -66 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 295 | 5 | 2 | 3 | 3.7 | O=C(Nc1ccc2ccccc2c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16274 | 55962 | 0 | None | -66 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 295 | 5 | 2 | 3 | 3.7 | O=C(Nc1ccc2ccccc2c1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10833949 | 56895 | 0 | None | -645 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 385 | 6 | 2 | 3 | 2.9 | O=C(NCc1ccc(I)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16496 | 56895 | 0 | None | -645 | 2 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 385 | 6 | 2 | 3 | 2.9 | O=C(NCc1ccc(I)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 168290235 | 192366 | 0 | None | -12882 | 20 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5201074 | 192366 | 0 | None | -12882 | 20 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222491 | 192366 | 0 | None | -12882 | 20 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 10085839 | 202797 | 0 | None | -251 | 3 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 294 | 7 | 3 | 2 | 2.9 | S=C(NCCCCCc1c[nH]cn1)NC1CCCCC1 | 10.1021/jm00012a025 | ||
| CHEMBL72571 | 202797 | 0 | None | -251 | 3 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 294 | 7 | 3 | 2 | 2.9 | S=C(NCCCCCc1c[nH]cn1)NC1CCCCC1 | 10.1021/jm00012a025 | ||
| 164617783 | 184007 | 0 | None | -123 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.8 | CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4848815 | 184007 | 0 | None | -123 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 388 | 8 | 4 | 4 | 2.8 | CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 10541297 | 57245 | 0 | None | -3090 | 2 | Guinea pig | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 287 | 8 | 2 | 3 | 2.7 | O=C(NCCCc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL16639 | 57245 | 0 | None | -3090 | 2 | Guinea pig | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 287 | 8 | 2 | 3 | 2.7 | O=C(NCCCc1ccccc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 10611565 | 97868 | 0 | None | -3235 | 2 | Guinea pig | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 263 | 5 | 2 | 3 | 2.7 | O=C(Nc1ccc(F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| CHEMBL274989 | 97868 | 0 | None | -3235 | 2 | Guinea pig | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 263 | 5 | 2 | 3 | 2.7 | O=C(Nc1ccc(F)cc1)OCCCc1c[nH]cn1 | 10.1021/jm9507688 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 10.1038/nchembio714 | ||
| 16093484 | 97610 | 6 | None | -3 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 229 | 0 | 2 | 3 | 2.6 | CC1NC(N)=Nc2ccc(Cl)c(Cl)c21 | 10.1016/j.bmcl.2007.10.080 | ||
| CHEMBL273170 | 97610 | 6 | None | -3 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 229 | 0 | 2 | 3 | 2.6 | CC1NC(N)=Nc2ccc(Cl)c(Cl)c21 | 10.1016/j.bmcl.2007.10.080 | ||
| 137645406 | 157360 | 0 | None | 4 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 491 | 8 | 0 | 7 | 5.4 | COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
| CHEMBL4084262 | 157360 | 0 | None | 4 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 491 | 8 | 0 | 7 | 5.4 | COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1 | 10.1021/acs.jmedchem.9b00412 | ||
| 46884153 | 8183 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 5 | 0 | 3 | 5.2 | C[C@@H](c1ncccc1Cl)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092494 | 8183 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 5 | 0 | 3 | 5.2 | C[C@@H](c1ncccc1Cl)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 53326726 | 57456 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 359 | 7 | 0 | 4 | 4.7 | C[C@H](C1=C(CCN(C)Cc2ccco2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669418 | 57456 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 359 | 7 | 0 | 4 | 4.7 | C[C@H](C1=C(CCN(C)Cc2ccco2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 135398737 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C4MD00578C | ||
| 38 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C4MD00578C | ||
| 722 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C4MD00578C | ||
| CHEMBL42 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C4MD00578C | ||
| DB00363 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C4MD00578C | ||
| 11846300 | 79856 | 3 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL213912 | 79856 | 3 | None | 2 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(C2=Nc3ccc(Cl)cc3Oc3ccccc32)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 46889257 | 7447 | 0 | None | 301 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 350 | 5 | 0 | 5 | 3.2 | COc1ccc(Cn2c(N3CC[C@@H](N(C)C)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2010.03.027 | ||
| CHEMBL1087367 | 7447 | 0 | None | 301 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 350 | 5 | 0 | 5 | 3.2 | COc1ccc(Cn2c(N3CC[C@@H](N(C)C)C3)nc3ccccc32)cc1 | 10.1016/j.bmcl.2010.03.027 | ||
| 11140 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | nan | ||
| 1784 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | nan | ||
| 26388 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | nan | ||
| CHEMBL398615 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | nan | ||
| DB13591 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | nan | ||
| 100 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| 2637 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| 5452 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| CHEMBL479 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| DB00679 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | nan | ||
| 1547484 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 654 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 9072 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL43064 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| DB00568 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | nan | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 10.1016/j.bmc.2008.06.030 | ||
| 49836295 | 18579 | 0 | None | 2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| CHEMBL1277935 | 18579 | 0 | None | 2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 373 | 2 | 1 | 2 | 4.3 | O=C(O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1 | 10.1021/jm100856p | ||
| 51039225 | 57460 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 359 | 7 | 1 | 4 | 3.8 | C[C@H](C1=C(CCN(C)Cc2ncc[nH]2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669422 | 57460 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 359 | 7 | 1 | 4 | 3.8 | C[C@H](C1=C(CCN(C)Cc2ncc[nH]2)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 46884669 | 8138 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 6 | 0 | 4 | 3.0 | COc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| CHEMBL1092258 | 8138 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 6 | 0 | 4 | 3.0 | COc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1 | 10.1016/j.bmcl.2010.02.055 | ||
| 9979272 | 205329 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1ncccc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| CHEMBL91729 | 205329 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 415 | 2 | 0 | 3 | 5.6 | Cc1ncccc1CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/acs.jmedchem.9b00447 | ||
| 57394285 | 70115 | 0 | None | -24 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 378 | 6 | 0 | 3 | 5.2 | Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| CHEMBL1946125 | 70115 | 0 | None | -24 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 378 | 6 | 0 | 3 | 5.2 | Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2012.01.022 | ||
| 44334252 | 4480 | 0 | None | -257 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 449 | 10 | 3 | 7 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL102390 | 4480 | 0 | None | -257 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 449 | 10 | 3 | 7 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](NC(=O)[C@@H](CO)NC(=O)OC(C)(C)C)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 14554123 | 118477 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 394 | 0 | 0 | 2 | 5.3 | CC(C)(C)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| CHEMBL342455 | 118477 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 394 | 0 | 0 | 2 | 5.3 | CC(C)(C)C(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1021/jm00105a069 | ||
| 44335412 | 106973 | 0 | None | 1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 413 | 8 | 0 | 6 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL318320 | 106973 | 0 | None | 1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 413 | 8 | 0 | 6 | 3.8 | CCOC(=O)N1CCN(CCCOc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)CC1 | 10.1016/s0960-894x(02)00648-0 | ||
| 162655663 | 180225 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 308 | 4 | 0 | 2 | 3.4 | CN(C)CCCN1C(=O)c2ccccc2CCc2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| CHEMBL4756695 | 180225 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 308 | 4 | 0 | 2 | 3.4 | CN(C)CCCN1C(=O)c2ccccc2CCc2ccccc21 | 10.1016/j.bmcl.2020.127493 | ||
| 44304284 | 162728 | 0 | None | -20 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 426 | 9 | 0 | 6 | 3.5 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(OC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL418691 | 162728 | 0 | None | -20 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 426 | 9 | 0 | 6 | 3.5 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)c3ccc(OC)cc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304445 | 201299 | 0 | None | -72 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 531 | 14 | 1 | 6 | 5.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL63112 | 201299 | 0 | None | -72 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 531 | 14 | 1 | 6 | 5.3 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304752 | 201521 | 0 | None | -3890 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 3.1 | C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL64406 | 201521 | 0 | None | -3890 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 3.1 | C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 127036981 | 136925 | 0 | None | 1 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 399 | 5 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753621 | 136925 | 0 | None | 1 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 399 | 5 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 2421311 | 68690 | 4 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 302 | 5 | 1 | 5 | 3.4 | NCCSc1nc(C2CCCCC2)n(-c2ccccc2)n1 | 10.1021/jm2011589 | ||
| CHEMBL1923534 | 68690 | 4 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 302 | 5 | 1 | 5 | 3.4 | NCCSc1nc(C2CCCCC2)n(-c2ccccc2)n1 | 10.1021/jm2011589 | ||
| 145988693 | 166613 | 0 | None | -32 | 17 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 524 | 7 | 1 | 3 | 7.1 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| CHEMBL4291048 | 166613 | 0 | None | -32 | 17 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 524 | 7 | 1 | 3 | 7.1 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | ||
| 162662985 | 181397 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 5.3 | C[C@H]1CN(CC[C@H]2CC[C@H](NC(=O)c3ccco3)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| CHEMBL4780335 | 181397 | 0 | None | -1 | 5 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 5.3 | C[C@H]1CN(CC[C@H]2CC[C@H](NC(=O)c3ccco3)CC2)CCc2ccc(Cl)cc21 | 10.1016/j.bmcl.2020.127681 | ||
| 24740862 | 147476 | 0 | None | -4 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 369 | 6 | 1 | 5 | 4.4 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL393436 | 147476 | 0 | None | -4 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 369 | 6 | 1 | 5 | 4.4 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F | 10.1016/j.bmcl.2009.09.024 | ||
| 127052467 | 140320 | 0 | None | -23 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819494 | 140320 | 0 | None | -23 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
| 168290238 | 191378 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 769 | 20 | 6 | 8 | 1.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5201159 | 191378 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 769 | 20 | 6 | 8 | 1.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168290238 | 191378 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 769 | 20 | 6 | 8 | 1.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5201159 | 191378 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 769 | 20 | 6 | 8 | 1.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 127052635 | 139677 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 288 | 5 | 3 | 3 | 2.0 | CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3805003 | 139677 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 288 | 5 | 3 | 3 | 2.0 | CC(C)CN/C(=N/C#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 127052467 | 140320 | 0 | None | -23 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3819494 | 140320 | 0 | None | -23 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 304 | 5 | 1 | 1 | 4.5 | c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2 | 10.1016/j.bmc.2016.05.053 | ||
| 11948707 | 165614 | 0 | None | -2041 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1016/j.bmcl.2006.01.052 | ||
| CHEMBL426317 | 165614 | 0 | None | -2041 | 13 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 373 | 7 | 0 | 8 | 0.6 | COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1 | 10.1016/j.bmcl.2006.01.052 | ||
| 44361141 | 32582 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 340 | 3 | 0 | 2 | 4.1 | CC(=O)N(C)CC/C=C1/c2ccc(Cl)cc2CCc2cccnc21 | 10.1021/jm00105a069 | ||
| CHEMBL141432 | 32582 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 340 | 3 | 0 | 2 | 4.1 | CC(=O)N(C)CC/C=C1/c2ccc(Cl)cc2CCc2cccnc21 | 10.1021/jm00105a069 | ||
| 155559236 | 174280 | 0 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 318 | 6 | 0 | 4 | 1.8 | CN1CCc2ccc(OCCCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| CHEMBL4563108 | 174280 | 0 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 318 | 6 | 0 | 4 | 1.8 | CN1CCc2ccc(OCCCCN3CCOCC3)cc2C1=O | 10.1016/j.bmcl.2019.04.015 | ||
| 27620 | 140287 | 13 | None | -38 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 297 | 5 | 0 | 2 | 3.8 | O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| CHEMBL3818994 | 140287 | 13 | None | -38 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 297 | 5 | 0 | 2 | 3.8 | O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1 | 10.1016/j.bmc.2016.05.053 | ||
| 132060763 | 162311 | 0 | None | -3 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 405 | 5 | 0 | 4 | 4.1 | C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| CHEMBL4173095 | 162311 | 0 | None | -3 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 405 | 5 | 0 | 4 | 4.1 | C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | ||
| 135409492 | 168604 | 46 | None | 1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 328 | 0 | 1 | 5 | 3.5 | Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1 | 10.1016/S0960-894X(96)00567-7 | ||
| CHEMBL440512 | 168604 | 46 | None | 1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 328 | 0 | 1 | 5 | 3.5 | Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1 | 10.1016/S0960-894X(96)00567-7 | ||
| 44304307 | 201542 | 0 | None | -134 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 388 | 12 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64479 | 201542 | 0 | None | -134 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 388 | 12 | 0 | 4 | 4.2 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)CCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 164610648 | 184255 | 0 | None | -87 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 374 | 7 | 4 | 4 | 2.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4852212 | 184255 | 0 | None | -87 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 374 | 7 | 4 | 4 | 2.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 164609729 | 184515 | 0 | None | -1412 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 2.3 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4856059 | 184515 | 0 | None | -1412 | 6 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 360 | 6 | 4 | 4 | 2.3 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 25218401 | 74596 | 0 | None | -43651 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 431 | 5 | 0 | 3 | 4.1 | C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C1=O | 10.1021/jm300011d | ||
| CHEMBL2031885 | 74596 | 0 | None | -43651 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 431 | 5 | 0 | 3 | 4.1 | C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C1=O | 10.1021/jm300011d | ||
| 127048828 | 139790 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 288 | 5 | 3 | 3 | 2.0 | CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3806255 | 139790 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 288 | 5 | 3 | 3 | 2.0 | CC(C)CN/C(=N/C#N)NC[C@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 13091268 | 77845 | 0 | None | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL210578 | 77845 | 0 | None | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 13091268 | 77845 | 0 | None | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
| CHEMBL210578 | 77845 | 0 | None | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.03.057 | ||
| 13091268 | 77845 | 0 | None | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL210578 | 77845 | 0 | None | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1021/jm0002432 | ||
| 71459604 | 83379 | 0 | None | -15 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1 | 10.1016/j.bmcl.2012.08.046 | ||
| CHEMBL2205811 | 83379 | 0 | None | -15 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 309 | 4 | 1 | 3 | 2.0 | COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1 | 10.1016/j.bmcl.2012.08.046 | ||
| 168288775 | 190850 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5193095 | 190850 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168288775 | 190850 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5193095 | 190850 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 9851785 | 51634 | 0 | None | -371 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 606 | 12 | 1 | 8 | 4.4 | C[C@@H](NC(=O)c1ccc(N(C)C)cc1)C(=O)N1CCN(CCCOc2ccc(-c3noc(CC4CCCC4)n3)c(F)c2)CC1 | 10.1016/j.bmcl.2003.11.038 | ||
| CHEMBL158595 | 51634 | 0 | None | -371 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 606 | 12 | 1 | 8 | 4.4 | C[C@@H](NC(=O)c1ccc(N(C)C)cc1)C(=O)N1CCN(CCCOc2ccc(-c3noc(CC4CCCC4)n3)c(F)c2)CC1 | 10.1016/j.bmcl.2003.11.038 | ||
| 44334038 | 4396 | 0 | None | -3162 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 453 | 10 | 1 | 6 | 3.0 | N#Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL101748 | 4396 | 0 | None | -3162 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 453 | 10 | 1 | 6 | 3.0 | N#Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1 | 10.1016/s0960-894x(02)00685-6 | ||
| 127036980 | 136822 | 0 | None | 16 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 4 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3752885 | 136822 | 0 | None | 16 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 4 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCc3ccccc3)c3c(n2)-c2ccccc2CC3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 44335405 | 5034 | 0 | None | -75 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 321 | 6 | 1 | 4 | 2.9 | N#Cc1ccc(-c2ccc(OCCCN3CCNCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| CHEMBL105594 | 5034 | 0 | None | -75 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 321 | 6 | 1 | 4 | 2.9 | N#Cc1ccc(-c2ccc(OCCCN3CCNCC3)cc2)cc1 | 10.1016/s0960-894x(02)00648-0 | ||
| 168283097 | 192291 | 0 | None | -66 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 311 | 9 | 4 | 5 | 0.8 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5186770 | 192291 | 0 | None | -66 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 311 | 9 | 4 | 5 | 0.8 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222043 | 192291 | 0 | None | -66 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 311 | 9 | 4 | 5 | 0.8 | CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)o1 | 10.1021/acs.jmedchem.1c00692 | ||
| 168284480 | 192308 | 0 | None | -66 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 330 | 6 | 4 | 4 | 1.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5197548 | 192308 | 0 | None | -66 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 330 | 6 | 4 | 4 | 1.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5222137 | 192308 | 0 | None | -66 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 330 | 6 | 4 | 4 | 1.3 | Cc1nc(N)oc1CCCN/C(N)=N/C(=O)NCc1ccccc1 | 10.1021/acs.jmedchem.1c00692 | ||
| 44395530 | 66738 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 546 | 10 | 2 | 5 | 5.0 | NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| CHEMBL187264 | 66738 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 546 | 10 | 2 | 5 | 5.0 | NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN([C@H](c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.060 | ||
| 10027435 | 47231 | 0 | None | 11 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 463 | 7 | 0 | 5 | 5.0 | Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL15456 | 47231 | 0 | None | 11 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 463 | 7 | 0 | 5 | 5.0 | Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 21474204 | 54489 | 0 | None | 3 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.9 | Cn1c(=O)sc2cc(CCCCN3CCC(Cc4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| CHEMBL16123 | 54489 | 0 | None | 3 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.9 | Cn1c(=O)sc2cc(CCCCN3CCC(Cc4ccccc4)CC3)ccc21 | 10.1016/s0960-894x(02)00123-3 | ||
| 10382839 | 116052 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 3.7 | CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00055a013 | ||
| CHEMBL336317 | 116052 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 3.7 | CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00055a013 | ||
| CHEMBL538750 | 116052 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 3.7 | CN(C)CCSC1c2ccccc2COc2ccc(C(=O)O)cc21 | 10.1021/jm00055a013 | ||
| 44326422 | 111900 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 279 | 2 | 1 | 2 | 3.4 | CNCC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL329685 | 111900 | 0 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 279 | 2 | 1 | 2 | 3.4 | CNCC1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 11500781 | 8119 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| CHEMBL1092126 | 8119 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 324 | 5 | 0 | 3 | 4.9 | Cc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12 | 10.1016/j.bmcl.2010.01.134 | ||
| 10851717 | 78068 | 1 | None | 11 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 299 | 1 | 0 | 4 | 2.9 | CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1 | 10.1021/jm010982y | ||
| CHEMBL2111782 | 78068 | 1 | None | 11 | 5 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 299 | 1 | 0 | 4 | 2.9 | CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1 | 10.1021/jm010982y | ||
| 44389292 | 63480 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 605 | 12 | 1 | 6 | 6.5 | CC(C)OC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| CHEMBL180233 | 63480 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 605 | 12 | 1 | 6 | 6.5 | CC(C)OC(=O)N(O)CCC#Cc1ccc(OCCCCN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.12.023 | ||
| 44326358 | 205571 | 0 | None | 3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 309 | 2 | 0 | 3 | 3.8 | CN(C)CC1C[C@@H]2c3ccccc3OCc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| CHEMBL93321 | 205571 | 0 | None | 3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 309 | 2 | 0 | 3 | 3.8 | CN(C)CC1C[C@@H]2c3ccccc3OCc3ccccc3[C@H]2O1 | 10.1016/j.bmcl.2004.03.069 | ||
| 2801 | 161325 | 56 | None | -1 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | nan | ||
| CHEMBL1200710 | 161325 | 56 | None | -1 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | nan | ||
| CHEMBL415 | 161325 | 56 | None | -1 | 28 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | nan | ||
| 132356 | 14508 | 1 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL1205688 | 14508 | 1 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| CHEMBL133778 | 14508 | 1 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 473 | 7 | 1 | 4 | 6.1 | O=C(O)c1ccc2c(c1)C(SCCN1CCC(Cc3ccccc3)CC1)c1ccccc1CO2 | 10.1021/jm00055a013 | ||
| 44334521 | 107350 | 0 | None | -85 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 262 | 6 | 1 | 4 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL319231 | 107350 | 0 | None | -85 | 3 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 262 | 6 | 1 | 4 | 1.7 | CC(=O)c1ccc(OCCCN2CC[C@H](N)C2)cc1 | 10.1016/s0960-894x(02)00685-6 | ||
| 53321511 | 57449 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 7 | 0 | 3 | 4.9 | C[C@H](C1=C(CCN(C)CCC(F)(F)F)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| CHEMBL1669411 | 57449 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 7 | 0 | 3 | 4.9 | C[C@H](C1=C(CCN(C)CCC(F)(F)F)Cc2ccccc21)c1cnccn1 | 10.1016/j.bmcl.2010.12.053 | ||
| 44288847 | 164757 | 0 | None | -64 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 535 | 7 | 2 | 5 | 3.9 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| CHEMBL42335 | 164757 | 0 | None | -64 | 5 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 535 | 7 | 2 | 5 | 3.9 | CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 | 10.1016/s0960-894x(99)00696-4 | ||
| 44334430 | 4388 | 0 | None | -3019 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 428 | 10 | 1 | 5 | 3.1 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL101691 | 4388 | 0 | None | -3019 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 428 | 10 | 1 | 5 | 3.1 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44334234 | 109191 | 0 | None | -9120 | 3 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 432 | 10 | 1 | 7 | 1.8 | Cn1cnc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL322678 | 109191 | 0 | None | -9120 | 3 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 432 | 10 | 1 | 7 | 1.8 | Cn1cnc(S(=O)(=O)N[C@H]2CCN(CCCOc3ccc(C(=O)C4CC4)cc3)C2)c1 | 10.1016/s0960-894x(02)00685-6 | ||
| 10065083 | 31887 | 1 | None | -141 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL140872 | 31887 | 1 | None | -141 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 10065083 | 31887 | 1 | None | -141 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| CHEMBL140872 | 31887 | 1 | None | -141 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.12.019 | ||
| 168273267 | 189905 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 698 | 17 | 5 | 7 | 2.2 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5179303 | 189905 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 698 | 17 | 5 | 7 | 2.2 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168273267 | 189905 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 698 | 17 | 5 | 7 | 2.2 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5179303 | 189905 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 698 | 17 | 5 | 7 | 2.2 | C[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 25128822 | 186898 | 0 | None | -1698 | 5 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 295 | 1 | 1 | 5 | 1.6 | CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL494093 | 186898 | 0 | None | -1698 | 5 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 295 | 1 | 1 | 5 | 1.6 | CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 10201714 | 197037 | 0 | None | -39 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 411 | 10 | 3 | 3 | 4.3 | O=C(NCCCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| CHEMBL58239 | 197037 | 0 | None | -39 | 2 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 411 | 10 | 3 | 3 | 4.3 | O=C(NCCCCc1c[nH]cn1)NCCC(c1ccc(Cl)cc1)c1ccccn1 | 10.1016/s0960-894x(03)00357-3 | ||
| 44334395 | 4892 | 0 | None | -2630 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 446 | 10 | 1 | 5 | 3.2 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL104808 | 4892 | 0 | None | -2630 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 446 | 10 | 1 | 5 | 3.2 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 46882133 | 5731 | 0 | None | -5 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 478 | 9 | 2 | 7 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| CHEMBL1078896 | 5731 | 0 | None | -5 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 478 | 9 | 2 | 7 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC | 10.1016/j.bmcl.2009.09.024 | ||
| 168294661 | 191804 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 764 | 19 | 6 | 8 | 2.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5207888 | 191804 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 764 | 19 | 6 | 8 | 2.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304079 | 200939 | 0 | None | -128 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 376 | 9 | 0 | 5 | 3.5 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC(C)C)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL61231 | 200939 | 0 | None | -128 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 376 | 9 | 0 | 5 | 3.5 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)CC(C)C)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 44304035 | 201618 | 0 | None | -13 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 410 | 9 | 0 | 5 | 3.7 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)Cc3ccccc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL64799 | 201618 | 0 | None | -13 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 410 | 9 | 0 | 5 | 3.7 | CCOC(=O)N1CCN(CCCOc2ccc(C(=O)Cc3ccccc3)cc2)CC1 | 10.1016/s0960-894x(02)00309-8 | ||
| 168294661 | 191804 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 764 | 19 | 6 | 8 | 2.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5207888 | 191804 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 764 | 19 | 6 | 8 | 2.2 | C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 44304312 | 162237 | 0 | None | -316 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 453 | 10 | 1 | 5 | 2.9 | N[C@H](Cc1ccc(F)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL417215 | 162237 | 0 | None | -316 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 453 | 10 | 1 | 5 | 2.9 | N[C@H](Cc1ccc(F)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304349 | 201113 | 0 | None | -173 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 566 | 14 | 1 | 7 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL62266 | 201113 | 0 | None | -173 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 566 | 14 | 1 | 7 | 4.9 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 127036979 | 136963 | 0 | None | -1 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 399 | 5 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| CHEMBL3753962 | 136963 | 0 | None | -1 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 399 | 5 | 1 | 5 | 3.6 | CN1CCN(c2nc(NCCc3ccccc3)nc3c2CCc2ccccc2-3)CC1 | 10.1016/j.bmcl.2015.12.035 | ||
| 127052292 | 139736 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 350 | 7 | 3 | 3 | 2.9 | N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| CHEMBL3805663 | 139736 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 350 | 7 | 3 | 3 | 2.9 | N#C/N=C(/NCCCc1ccccc1)NC[C@@H]1CC[C@H](c2c[nH]cn2)C1 | 10.1021/acs.jmedchem.6b00120 | ||
| 50878551 | 90314 | 60 | None | -21 | 18 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | ||
| CHEMBL2391541 | 90314 | 60 | None | -21 | 18 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | ||
| 44334396 | 4847 | 0 | None | -3467 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 446 | 10 | 1 | 5 | 3.2 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3F)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| CHEMBL104618 | 4847 | 0 | None | -3467 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 446 | 10 | 1 | 5 | 3.2 | O=C(c1ccc(OCCCN2CC[C@H](NS(=O)(=O)c3ccccc3F)C2)cc1)C1CC1 | 10.1016/s0960-894x(02)00685-6 | ||
| 44582676 | 189187 | 0 | None | -7 | 17 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| CHEMBL516088 | 189187 | 0 | None | -7 | 17 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | ||
| 168274424 | 189538 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5173453 | 189538 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168297312 | 191928 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5209546 | 191928 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168274424 | 189538 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5173453 | 189538 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 834 | 21 | 7 | 9 | 2.8 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168297312 | 191928 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| CHEMBL5209546 | 191928 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 785 | 21 | 7 | 9 | 0.7 | CC(C)[C@H](NC(=O)CCN1CCC(Oc2ccccc2Cc2ccccc2)CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.2c00125 | ||
| 168278471 | 192246 | 0 | None | -229 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 312 | 8 | 4 | 4 | 1.5 | CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5183205 | 192246 | 0 | None | -229 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 312 | 8 | 4 | 4 | 1.5 | CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| CHEMBL5221757 | 192246 | 0 | None | -229 | 6 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 312 | 8 | 4 | 4 | 1.5 | CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | ||
| 164622886 | 185360 | 0 | None | -93 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 374 | 7 | 4 | 4 | 2.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| CHEMBL4869389 | 185360 | 0 | None | -93 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 374 | 7 | 4 | 4 | 2.4 | Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC[C@@H](C)c1ccccc1 | 10.1016/j.ejmech.2021.113190 | ||
| 44304332 | 199659 | 0 | None | -20417 | 3 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 399 | 9 | 1 | 5 | 2.3 | O=C(c1ccc(OCCCN2CCN(C(=O)C[C@H]3CCCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60435 | 199659 | 0 | None | -20417 | 3 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 399 | 9 | 1 | 5 | 2.3 | O=C(c1ccc(OCCCN2CCN(C(=O)C[C@H]3CCCN3)CC2)cc1)C1CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304719 | 201034 | 0 | None | -20892 | 3 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 425 | 10 | 2 | 6 | 1.5 | N[C@H](Cc1c[nH]cn1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL61792 | 201034 | 0 | None | -20892 | 3 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 425 | 10 | 2 | 6 | 1.5 | N[C@H](Cc1c[nH]cn1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 135559170 | 101590 | 0 | None | -1479 | 7 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 391 | 4 | 1 | 5 | 2.5 | COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1 | 10.1021/jm970159v | ||
| CHEMBL302021 | 101590 | 0 | None | -1479 | 7 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 391 | 4 | 1 | 5 | 2.5 | COc1ccccc1N1CCN(CC2CN3C(=O)Nc4ccccc4C3=N2)CC1 | 10.1021/jm970159v | ||
| 25218143 | 74584 | 0 | None | -5011 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 431 | 6 | 1 | 3 | 4.1 | O=C(NC1CCCC1)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1 | 10.1021/jm300011d | ||
| CHEMBL2031873 | 74584 | 0 | None | -5011 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 431 | 6 | 1 | 3 | 4.1 | O=C(NC1CCCC1)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)cc1 | 10.1021/jm300011d | ||
| 46216789 | 198644 | 0 | None | -2 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 341 | 7 | 1 | 1 | 5.3 | c1ccc(CCCCNCC2c3ccccc3Cc3ccccc32)cc1 | 10.1016/j.bmcl.2009.12.064 | ||
| CHEMBL597528 | 198644 | 0 | None | -2 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 341 | 7 | 1 | 1 | 5.3 | c1ccc(CCCCNCC2c3ccccc3Cc3ccccc32)cc1 | 10.1016/j.bmcl.2009.12.064 | ||
| 44304270 | 199563 | 0 | None | -6 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 442 | 11 | 0 | 5 | 5.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccc(C)s3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL60383 | 199563 | 0 | None | -6 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 442 | 11 | 0 | 5 | 5.0 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)c3ccc(C)s3)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 25147771 | 173666 | 0 | None | -3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 357 | 4 | 1 | 6 | 3.2 | CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1 | 10.1021/jm800876b | ||
| CHEMBL454890 | 173666 | 0 | None | -3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 357 | 4 | 1 | 6 | 3.2 | CN1CCN(c2nc(NCc3ccoc3)c3cc(Cl)ccc3n2)CC1 | 10.1021/jm800876b | ||
| 44343936 | 10956 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 369 | 1 | 0 | 3 | 3.5 | CC(=O)N1CCCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| CHEMBL117745 | 10956 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 369 | 1 | 0 | 3 | 3.5 | CC(=O)N1CCCN(C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | 10.1016/s0960-894x(98)00626-x | ||
| 44350664 | 117646 | 0 | None | -9 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL340816 | 117646 | 0 | None | -9 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| CHEMBL553417 | 117646 | 0 | None | -9 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | 10.1016/j.bmc.2008.06.030 | ||
| 13091359 | 113040 | 0 | None | -1380 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| CHEMBL3321790 | 113040 | 0 | None | -1380 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.5 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1 | 10.1016/j.bmcl.2014.07.018 | ||
| 44304036 | 96334 | 0 | None | -17 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 360 | 8 | 0 | 5 | 3.0 | C=C(C)C(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| CHEMBL264761 | 96334 | 0 | None | -17 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 360 | 8 | 0 | 5 | 3.0 | C=C(C)C(=O)c1ccc(OCCCN2CCN(C(=O)OCC)CC2)cc1 | 10.1016/s0960-894x(02)00309-8 | ||
| 1278 | 2119 | 79 | None | -1778 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1021/jm8007618 | ||
| 1279 | 2119 | 79 | None | -1778 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1021/jm8007618 | ||
| 4908365 | 2119 | 79 | None | -1778 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1021/jm8007618 | ||
| CHEMBL129198 | 2119 | 79 | None | -1778 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 277 | 1 | 1 | 2 | 2.2 | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl | 10.1021/jm8007618 | ||
| 44304743 | 100143 | 0 | None | -57 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 431 | 13 | 1 | 5 | 3.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)CC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL291847 | 100143 | 0 | None | -57 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 431 | 13 | 1 | 5 | 3.7 | CCCCCC(=O)c1ccc(OCCCN2CCN(C(=O)[C@@H](N)CC(C)C)CC2)cc1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304064 | 102337 | 0 | None | -323 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 451 | 10 | 2 | 6 | 2.5 | N[C@H](Cc1ccc(O)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL305371 | 102337 | 0 | None | -323 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 451 | 10 | 2 | 6 | 2.5 | N[C@H](Cc1ccc(O)cc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 44304313 | 199900 | 0 | None | -426 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 441 | 10 | 1 | 6 | 2.8 | N[C@H](Cc1ccsc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| CHEMBL60559 | 199900 | 0 | None | -426 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 441 | 10 | 1 | 6 | 2.8 | N[C@H](Cc1ccsc1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1 | 10.1016/s0960-894x(02)00310-4 | ||
| 11525848 | 114093 | 26 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 479 | 9 | 3 | 7 | 3.3 | COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(C(=O)O)cc4)c3c(=O)[nH]2)c1 | nan | ||
| CHEMBL3337894 | 114093 | 26 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 479 | 9 | 3 | 7 | 3.3 | COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(C(=O)O)cc4)c3c(=O)[nH]2)c1 | nan | ||
| 130442572 | 171342 | 0 | None | -208 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| CHEMBL4469848 | 171342 | 0 | None | -208 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| 1164 | 1600 | 25 | None | - | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| 1626 | 1600 | 25 | None | - | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| 3345 | 1600 | 25 | None | - | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| CHEMBL596 | 1600 | 25 | None | - | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| DB00813 | 1600 | 25 | None | - | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 336 | 6 | 0 | 2 | 4.1 | CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| 2031 | 119927 | 30 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 311 | 8 | 0 | 3 | 3.7 | CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL353846 | 119927 | 30 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 311 | 8 | 0 | 3 | 3.7 | CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1 | None | ||
| 2142 | 3047 | 54 | None | -7585 | 36 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | None | -7585 | 36 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | None | -7585 | 36 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | None | -7585 | 36 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | None | -7585 | 36 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | None | -7585 | 36 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4919 | 204511 | 21 | None | - | 9 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 287 | 5 | 1 | 2 | 3.9 | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 | None | ||
| CHEMBL86715 | 204511 | 21 | None | - | 9 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 287 | 5 | 1 | 2 | 3.9 | OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 | None | ||
| 2284 | 3133 | 27 | None | -10 | 28 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | None | -10 | 28 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | None | -10 | 28 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | None | -10 | 28 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | None | -10 | 28 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 1613 | 2316 | 44 | None | - | 44 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | None | - | 44 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | None | - | 44 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | None | - | 44 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | None | - | 44 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3689 | 102298 | 47 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 325 | 5 | 2 | 3 | 3.8 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | None | ||
| CHEMBL1372983 | 102298 | 47 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 325 | 5 | 2 | 3 | 3.8 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | None | ||
| CHEMBL305187 | 102298 | 47 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 325 | 5 | 2 | 3 | 3.8 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | None | ||
| 4601 | 205020 | 29 | None | - | 17 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | None | ||
| CHEMBL1201023 | 205020 | 29 | None | - | 17 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | None | ||
| CHEMBL900 | 205020 | 29 | None | - | 17 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | None | ||
| 2865 | 4079 | 67 | None | -1047 | 53 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | None | -1047 | 53 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | None | -1047 | 53 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | None | -1047 | 53 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | None | -1047 | 53 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 100 | 3745 | 52 | None | -23 | 55 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | None | -23 | 55 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | None | -23 | 55 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | None | -23 | 55 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | None | -23 | 55 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2389 | 3279 | 114 | None | -331 | 67 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | None | -331 | 67 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | None | -331 | 67 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | None | -331 | 67 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | None | -331 | 67 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 3191 | 102385 | 93 | None | - | 25 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL305660 | 102385 | 93 | None | - | 25 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 2337 | 3205 | 72 | None | -1 | 62 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | None | -1 | 62 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | None | -1 | 62 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | None | -1 | 62 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | None | -1 | 62 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 1385580 | 29063 | 73 | None | - | 5 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | None | ||
| 4615 | 29063 | 73 | None | - | 5 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | None | ||
| CHEMBL13828 | 29063 | 73 | None | - | 5 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | None | ||
| 1210 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | None | 7 | 20 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1227 | 2454 | 35 | None | -5 | 11 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | None | -5 | 11 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | None | -5 | 11 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | None | -5 | 11 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | None | -5 | 11 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | None | -5 | 11 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 11976 | 907 | 54 | None | - | 23 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| 667467 | 907 | 54 | None | - | 23 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| CHEMBL908 | 907 | 54 | None | - | 23 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| DB01239 | 907 | 54 | None | - | 23 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| 1027 | 1546 | 67 | None | -6 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | Guide to Pharmacology | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 18446005 | ||
| 3241 | 1546 | 67 | None | -6 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | Guide to Pharmacology | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 18446005 | ||
| 7176 | 1546 | 67 | None | -6 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | Guide to Pharmacology | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 18446005 | ||
| CHEMBL1106 | 1546 | 67 | None | -6 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | Guide to Pharmacology | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 18446005 | ||
| DB00751 | 1546 | 67 | None | -6 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | Guide to Pharmacology | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | 18446005 | ||
| 10102 | 2509 | 83 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 7612054 | ||
| 1824 | 2509 | 83 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 7612054 | ||
| 65906 | 2509 | 83 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 7612054 | ||
| CHEMBL94454 | 2509 | 83 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 7612054 | ||
| DB12523 | 2509 | 83 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 7612054 | ||
| 2200 | 20003 | 57 | None | 26 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | None | ||
| CHEMBL1256819 | 20003 | 57 | None | 26 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | None | ||
| CHEMBL1305 | 20003 | 57 | None | 26 | 2 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | None | ||
| 1605 | 2310 | 110 | None | 1 | 4 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 3957 | 2310 | 110 | None | 1 | 4 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 7216 | 2310 | 110 | None | 1 | 4 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| CHEMBL998 | 2310 | 110 | None | 1 | 4 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| DB00455 | 2310 | 110 | None | 1 | 4 | Guinea pig | 8.2 | pKd | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 2600 | 3720 | 73 | None | -3 | 13 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 2608 | 3720 | 73 | None | -3 | 13 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 5405 | 3720 | 73 | None | -3 | 13 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| CHEMBL17157 | 3720 | 73 | None | -3 | 13 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| DB00342 | 3720 | 73 | None | -3 | 13 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 4543 | 169982 | 36 | None | -1 | 29 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | None | -1 | 29 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | None | -1 | 29 | Human | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 11291 | 98340 | 21 | None | 4 | 2 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | None | ||
| CHEMBL278398 | 98340 | 21 | None | 4 | 2 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | None | ||
| 277 | 1274 | 55 | None | 2 | 45 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 2913 | 1274 | 55 | None | 2 | 45 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 765 | 1274 | 55 | None | 2 | 45 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| CHEMBL516 | 1274 | 55 | None | 2 | 45 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| DB00434 | 1274 | 55 | None | 2 | 45 | Guinea pig | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 1227 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | None | 2 | 11 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1228 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.0 | pKd | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.0 | pKd | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.0 | pKd | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.0 | pKd | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | None | 5 | 4 | Guinea pig | 8.0 | pKd | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2762 | 3802 | 28 | None | -9 | 2 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| 5587 | 3802 | 28 | None | -9 | 2 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| 7318 | 3802 | 28 | None | -9 | 2 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| CHEMBL1241 | 3802 | 28 | None | -9 | 2 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| DB00792 | 3802 | 28 | None | -9 | 2 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | 14667234 | ||
| 1225 | 1443 | 24 | None | -1 | 21 | Human | 9.0 | pKd | = | 9 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 15093820 | ||
| 3958 | 1443 | 24 | None | -1 | 21 | Human | 9.0 | pKd | = | 9 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 15093820 | ||
| 667477 | 1443 | 24 | None | -1 | 21 | Human | 9.0 | pKd | = | 9 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 15093820 | ||
| CHEMBL860 | 1443 | 24 | None | -1 | 21 | Human | 9.0 | pKd | = | 9 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 15093820 | ||
| DB01142 | 1443 | 24 | None | -1 | 21 | Human | 9.0 | pKd | = | 9 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 15093820 | ||
| None | 214387 | 0 | 3H-Histamine | 8912 | 2 | Guinea pig | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 139 | 3 | 2 | 2 | 0.6 | CC(CC1=CN=CN1)NC | None | ||
| None | 214388 | 0 | 3H-Histamine | 60255 | 2 | Guinea pig | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 139 | 2 | 2 | 2 | 0.9 | CC(C1=CN=CN1)C(C)N | None | ||
| 277 | 1274 | 55 | 3H-MEPYRAMINE | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 2913 | 1274 | 55 | 3H-MEPYRAMINE | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 765 | 1274 | 55 | 3H-MEPYRAMINE | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| CHEMBL516 | 1274 | 55 | 3H-MEPYRAMINE | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| DB00434 | 1274 | 55 | 3H-MEPYRAMINE | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 1225 | 1443 | 24 | 3H-trans-H2-PAT,(-) | -1 | 21 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-trans-H2-PAT,(-) | -1 | 21 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-trans-H2-PAT,(-) | -1 | 21 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-trans-H2-PAT,(-) | -1 | 21 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-trans-H2-PAT,(-) | -1 | 21 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 277 | 1274 | 55 | 3H-MEPYRAMINE | 2 | 45 | Guinea pig | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 2913 | 1274 | 55 | 3H-MEPYRAMINE | 2 | 45 | Guinea pig | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 765 | 1274 | 55 | 3H-MEPYRAMINE | 2 | 45 | Guinea pig | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| CHEMBL516 | 1274 | 55 | 3H-MEPYRAMINE | 2 | 45 | Guinea pig | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| DB00434 | 1274 | 55 | 3H-MEPYRAMINE | 2 | 45 | Guinea pig | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 1225 | 1443 | 24 | 3H-trans-H2-PAT,(-) | 1 | 21 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 1225 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-trans-H2-PAT,(-) | 1 | 21 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-trans-H2-PAT,(-) | 1 | 21 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-trans-H2-PAT,(-) | 1 | 21 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-trans-H2-PAT,(-) | 1 | 21 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 46780481 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 9903970 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3187365 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3544974 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 180 | 397 | 50 | 3H-PYRILAMINE | 1 | 38 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-PYRILAMINE | 1 | 38 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-PYRILAMINE | 1 | 38 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-PYRILAMINE | 1 | 38 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-PYRILAMINE | 1 | 38 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 1225 | 1443 | 24 | 3H-PYRILAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-PYRILAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-PYRILAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-PYRILAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-PYRILAMINE | -1 | 21 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 2726 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 2286 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 1225 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 135 | 2496 | 38 | 3H-MEPYRAMINE | -1 | 57 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-MEPYRAMINE | -1 | 57 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-MEPYRAMINE | -1 | 57 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-MEPYRAMINE | -1 | 57 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-MEPYRAMINE | -1 | 57 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 16667681 | 214389 | 0 | 3H-MEPYRAMINE | 4 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1225 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 1816 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 135398745 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 135 | 2496 | 38 | 3H-doxepin | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-doxepin | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-doxepin | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-doxepin | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-doxepin | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1225 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-MEPYRAMINE | -1 | 21 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 135 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1210 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-PYRILAMINE | 7 | 20 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 1225 | 1443 | 24 | 3H-doxepin | -1 | 21 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-doxepin | -1 | 21 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-doxepin | -1 | 21 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-doxepin | -1 | 21 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-doxepin | -1 | 21 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 180 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 1210 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1225 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-MEPYRAMINE | 1 | 21 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1816 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 1816 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| None | 214372 | 0 | 3H-Histamine | -4 | 6 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 125 | 2 | 2 | 2 | 0.3 | CC(CC1=CN=CN1)N | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 72287 | 214391 | 0 | 3H-doxepin | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 328 | 5 | 0 | 4 | 4.5 | CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 103 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 2875 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 5736 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL285802 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB09225 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1816 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | 3H-MEPYRAMINE | 3 | 16 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 180 | 397 | 50 | 3H-doxepin | -1 | 38 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-doxepin | -1 | 38 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-doxepin | -1 | 38 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-doxepin | -1 | 38 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-doxepin | -1 | 38 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 1210 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-trans-H2-PAT,(-) | 7 | 20 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1228 | 3805 | 31 | 3H-trans-H2-PAT,(-) | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-trans-H2-PAT,(-) | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-trans-H2-PAT,(-) | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-trans-H2-PAT,(-) | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-trans-H2-PAT,(-) | 5 | 4 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 1225 | 1443 | 24 | 3H-MEPYRAMINE | -2 | 21 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | 3H-MEPYRAMINE | -2 | 21 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | 3H-MEPYRAMINE | -2 | 21 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | 3H-MEPYRAMINE | -2 | 21 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | 3H-MEPYRAMINE | -2 | 21 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3246155 | 214183 | 0 | 3H-MEPYRAMINE | -3 | 16 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 307 | 4 | 0 | 2 | 4.4 | CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4 | None | ||
| 1227 | 2454 | 35 | 3H-trans-H2-PAT,(-) | 2 | 11 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-trans-H2-PAT,(-) | 2 | 11 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-trans-H2-PAT,(-) | 2 | 11 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-trans-H2-PAT,(-) | 2 | 11 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-trans-H2-PAT,(-) | 2 | 11 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-trans-H2-PAT,(-) | 2 | 11 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4011 | 81996 | 43 | 3H-doxepin | 6 | 23 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | ||
| CHEMBL21731 | 81996 | 43 | 3H-doxepin | 6 | 23 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | ||
| 2247 | 502 | 77 | 3H-PYRILAMINE | 3 | 41 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 2247 | 502 | 77 | 3H-PYRILAMINE | -4 | 41 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 249 | 502 | 77 | 3H-PYRILAMINE | 3 | 41 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 249 | 502 | 77 | 3H-PYRILAMINE | -4 | 41 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 2603 | 502 | 77 | 3H-PYRILAMINE | 3 | 41 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 2603 | 502 | 77 | 3H-PYRILAMINE | -4 | 41 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| CHEMBL296419 | 502 | 77 | 3H-PYRILAMINE | 3 | 41 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| CHEMBL296419 | 502 | 77 | 3H-PYRILAMINE | -4 | 41 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| DB00637 | 502 | 77 | 3H-PYRILAMINE | 3 | 41 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| DB00637 | 502 | 77 | 3H-PYRILAMINE | -4 | 41 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 565544 | 109255 | 9 | 3H-Histamine | 354 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 125 | 2 | 2 | 2 | 0.5 | CC(CN)c1cnc[nH]1 | None | ||
| CHEMBL322988 | 109255 | 9 | 3H-Histamine | 354 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 125 | 2 | 2 | 2 | 0.5 | CC(CN)c1cnc[nH]1 | None | ||
| 5281878 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5281881 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 948 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 968 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL42055 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL54661 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00875 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 46780481 | 107045 | 18 | 3H-PYRILAMINE | -5 | 53 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 9903970 | 107045 | 18 | 3H-PYRILAMINE | -5 | 53 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3187365 | 107045 | 18 | 3H-PYRILAMINE | -5 | 53 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3544974 | 107045 | 18 | 3H-PYRILAMINE | -5 | 53 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 180 | 397 | 50 | 3H-PYRILAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-PYRILAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-PYRILAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-PYRILAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-PYRILAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 1400 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 3658 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 7199 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 91513 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL896 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00557 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 135 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 1227 | 2454 | 35 | 3H-trans-H2-PAT,(-) | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-trans-H2-PAT,(-) | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-trans-H2-PAT,(-) | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-trans-H2-PAT,(-) | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-trans-H2-PAT,(-) | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-trans-H2-PAT,(-) | -2 | 11 | Human | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 180 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-MEPYRAMINE | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 3246155 | 214183 | 0 | 3H-doxepin | -3 | 16 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 307 | 4 | 0 | 2 | 4.4 | CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4 | None | ||
| 1228 | 3805 | 31 | 3H-trans-H2-PAT,(-) | -5 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-trans-H2-PAT,(-) | -5 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-trans-H2-PAT,(-) | -5 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-trans-H2-PAT,(-) | -5 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-trans-H2-PAT,(-) | -5 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 180 | 397 | 50 | UNDEFINED | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | UNDEFINED | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | UNDEFINED | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | UNDEFINED | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | UNDEFINED | -1 | 38 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | 5 | 4 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 16667681 | 214389 | 0 | 3H-MEPYRAMINE | 4 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | 2 | 11 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2749 | 341 | 0 | 3H-MEPYRAMINE | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 5574 | 341 | 0 | 3H-MEPYRAMINE | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7237 | 341 | 0 | 3H-MEPYRAMINE | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL829 | 341 | 0 | 3H-MEPYRAMINE | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01246 | 341 | 0 | 3H-MEPYRAMINE | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 3246155 | 214183 | 0 | 3H-MEPYRAMINE | -5 | 16 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 307 | 4 | 0 | 2 | 4.4 | CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4 | None | ||
| 5584 | 214390 | 0 | 3H-doxepin | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 294 | 4 | 0 | 2 | 4.1 | CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)CN(C)C | None | ||
| None | 214418 | 0 | 3H-MEPYRAMINE | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 296 | 3 | 0 | 3 | 4.4 | C1CCN(C1)CCN2C3=CC=CC=C3SC4=CC=CC=C42 | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 135398737 | 944 | 89 | 3H-trans-H2-PAT,(-) | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-trans-H2-PAT,(-) | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-trans-H2-PAT,(-) | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-trans-H2-PAT,(-) | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-trans-H2-PAT,(-) | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 180 | 397 | 50 | 3H-MEPYRAMINE | 1 | 38 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-MEPYRAMINE | 1 | 38 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-MEPYRAMINE | 1 | 38 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-MEPYRAMINE | 1 | 38 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-MEPYRAMINE | 1 | 38 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 1816 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | 3H-PYRILAMINE | -3 | 16 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 4011 | 81996 | 43 | UNDEFINED | 6 | 23 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | ||
| CHEMBL21731 | 81996 | 43 | UNDEFINED | 6 | 23 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | ||
| 135 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 135 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1524 | 2150 | 89 | 3H-MEPYRAMINE | -2 | 51 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 197 | 2150 | 89 | 3H-MEPYRAMINE | -2 | 51 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 3822 | 2150 | 89 | 3H-MEPYRAMINE | -2 | 51 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 88 | 2150 | 89 | 3H-MEPYRAMINE | -2 | 51 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| CHEMBL51 | 2150 | 89 | 3H-MEPYRAMINE | -2 | 51 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| DB12465 | 2150 | 89 | 3H-MEPYRAMINE | -2 | 51 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1712 | 2456 | 0 | 3H-doxepin | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 4078 | 2456 | 0 | 3H-doxepin | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 7227 | 2456 | 0 | 3H-doxepin | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| CHEMBL1088 | 2456 | 0 | 3H-doxepin | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| DB00933 | 2456 | 0 | 3H-doxepin | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 1712 | 2456 | 0 | UNDEFINED | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 4078 | 2456 | 0 | UNDEFINED | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 7227 | 2456 | 0 | UNDEFINED | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| CHEMBL1088 | 2456 | 0 | UNDEFINED | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| DB00933 | 2456 | 0 | UNDEFINED | 1 | 21 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1210 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-MEPYRAMINE | 7 | 20 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1222 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1170 | 1603 | 71 | 3H-MEPYRAMINE | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 3348 | 1603 | 71 | 3H-MEPYRAMINE | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 4819 | 1603 | 71 | 3H-MEPYRAMINE | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 74685737 | 1603 | 71 | 3H-MEPYRAMINE | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| CHEMBL914 | 1603 | 71 | 3H-MEPYRAMINE | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| DB00950 | 1603 | 71 | 3H-MEPYRAMINE | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 115237 | 55296 | 113 | 3H-PYRILAMINE | -7 | 54 | Guinea pig | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| CHEMBL1621 | 55296 | 113 | 3H-PYRILAMINE | -7 | 54 | Guinea pig | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| 4543 | 169982 | 36 | 3H-MEPYRAMINE | -1 | 29 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | 3H-MEPYRAMINE | -1 | 29 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | 3H-MEPYRAMINE | -1 | 29 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| None | 215179 | 0 | UNDEFINED | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 311 | 4 | 1 | 4 | 2.7 | C1COC2=C1C=CC=C2OC(C3CNCCO3)C4=CC=CC=C4 | None | ||
| None | 215180 | 0 | UNDEFINED | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 305 | 4 | 1 | 3 | 3.1 | C1COC(CN1)C(C2=CC=CC=C2)OC3=C(C(=CC=C3)F)F | None | ||
| None | 215181 | 0 | UNDEFINED | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 301 | 4 | 1 | 3 | 3.2 | CC1=C(C=CC(=C1)F)OC(C2CNCCO2)C3=CC=CC=C3 | None | ||
| None | 215182 | 0 | UNDEFINED | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 3.6 | C1COC(CN1)C(C2=CC=CC=C2)OC3=C(C=C(C=C3)F)Cl | None | ||
| None | 215183 | 0 | UNDEFINED | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 317 | 5 | 1 | 4 | 2.9 | COC1=C(C=CC(=C1)F)OC(C2CNCCO2)C3=CC=CC=C3 | None | ||
| 277 | 1274 | 55 | None | -2 | 45 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 2913 | 1274 | 55 | None | -2 | 45 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 765 | 1274 | 55 | None | -2 | 45 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| CHEMBL516 | 1274 | 55 | None | -2 | 45 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| DB00434 | 1274 | 55 | None | -2 | 45 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 3246155 | 214183 | 0 | 3H-MEPYRAMINE | -46 | 16 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 307 | 4 | 0 | 2 | 4.4 | CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4 | None | ||
| 1204 | 1901 | 114 | 3H-Histamine | -46 | 23 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-Histamine | -46 | 23 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-Histamine | -46 | 23 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-Histamine | -46 | 23 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-Histamine | -46 | 23 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-Histamine | -46 | 23 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 21722 | 214239 | 0 | 3H-MEPYRAMINE | -1 | 5 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 2 | 4.3 | CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31 | None | ||
| 1353 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 46222048 | 8896 | 0 | UNDEFINED | -4365 | 13 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 260 | 4 | 1 | 2 | 4.0 | CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1 | None | ||
| CHEMBL1098230 | 8896 | 0 | UNDEFINED | -4365 | 13 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 260 | 4 | 1 | 2 | 4.0 | CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1 | None | ||
| 18922713 | 98046 | 0 | 3H-PYRILAMINE | -12882 | 8 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1 | None | ||
| CHEMBL276031 | 98046 | 0 | 3H-PYRILAMINE | -12882 | 8 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 298 | 6 | 1 | 2 | 4.0 | CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1 | None | ||
| 54841 | 201437 | 51 | 3H-PYRILAMINE | -2 | 28 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| CHEMBL641 | 201437 | 51 | 3H-PYRILAMINE | -2 | 28 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| 12057539 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3947 | 214378 | 0 | 3H-MEPYRAMINE | -147 | 15 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 418 | 7 | 0 | 3 | 5.8 | CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl | None | ||
| 179 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 179 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 2159 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 2159 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 963 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 963 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| CHEMBL243712 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| CHEMBL243712 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| DB06288 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| DB06288 | 396 | 107 | 3H-PYRILAMINE | -4365 | 50 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 2247 | 502 | 77 | 3H-Histamine | -4 | 41 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 249 | 502 | 77 | 3H-Histamine | -4 | 41 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 2603 | 502 | 77 | 3H-Histamine | -4 | 41 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| CHEMBL296419 | 502 | 77 | 3H-Histamine | -4 | 41 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| DB00637 | 502 | 77 | 3H-Histamine | -4 | 41 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
| 1001 | 613 | 91 | 3H-Histamine | -3 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| 2144 | 613 | 91 | 3H-Histamine | -3 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| CHEMBL610 | 613 | 91 | 3H-Histamine | -3 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| DB04325 | 613 | 91 | 3H-Histamine | -3 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| 31101 | 720 | 39 | 3H-PYRILAMINE | -14454 | 35 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
| 35 | 720 | 39 | 3H-PYRILAMINE | -14454 | 35 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
| 403 | 720 | 39 | 3H-PYRILAMINE | -14454 | 35 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
| CHEMBL493 | 720 | 39 | 3H-PYRILAMINE | -14454 | 35 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
| DB01200 | 720 | 39 | 3H-PYRILAMINE | -14454 | 35 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | ||
| 2554 | 784 | 115 | 3H-doxepin | 1 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 489 | 784 | 115 | 3H-doxepin | 1 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 5339 | 784 | 115 | 3H-doxepin | 1 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| CHEMBL108 | 784 | 115 | 3H-doxepin | 1 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| DB00564 | 784 | 115 | 3H-doxepin | 1 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 1222 | 868 | 0 | 3H-Histamine | -1 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | 3H-Histamine | -1 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | 3H-Histamine | -1 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | 3H-Histamine | -1 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | 3H-Histamine | -1 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1210 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-Histamine | -12 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1231 | 924 | 112 | 3H-doxepin | -81 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 252 | 5 | 3 | 4 | 0.6 | N#CNC(=NC)NCCSCc1nc[nH]c1C | None | ||
| 2756 | 924 | 112 | 3H-doxepin | -81 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 252 | 5 | 3 | 4 | 0.6 | N#CNC(=NC)NCCSCc1nc[nH]c1C | None | ||
| 645 | 924 | 112 | 3H-doxepin | -81 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 252 | 5 | 3 | 4 | 0.6 | N#CNC(=NC)NCCSCc1nc[nH]c1C | None | ||
| CHEMBL30 | 924 | 112 | 3H-doxepin | -81 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 252 | 5 | 3 | 4 | 0.6 | N#CNC(=NC)NCCSCc1nc[nH]c1C | None | ||
| DB00501 | 924 | 112 | 3H-doxepin | -81 | 7 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 252 | 5 | 3 | 4 | 0.6 | N#CNC(=NC)NCCSCc1nc[nH]c1C | None | ||
| 1248 | 1396 | 27 | 3H-MEPYRAMINE | -208 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 161 | 4 | 2 | 3 | 0.6 | CN(CCCSC(=N)N)C | None | ||
| 3077 | 1396 | 27 | 3H-MEPYRAMINE | -208 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 161 | 4 | 2 | 3 | 0.6 | CN(CCCSC(=N)N)C | None | ||
| 90045 | 1396 | 27 | 3H-MEPYRAMINE | -208 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 161 | 4 | 2 | 3 | 0.6 | CN(CCCSC(=N)N)C | None | ||
| CHEMBL12344 | 1396 | 27 | 3H-MEPYRAMINE | -208 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 161 | 4 | 2 | 3 | 0.6 | CN(CCCSC(=N)N)C | None | ||
| 1224 | 1404 | 79 | 3H-Histamine | -2 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-Histamine | -2 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-Histamine | -2 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-Histamine | -2 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-Histamine | -2 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-Histamine | -2 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 1170 | 1603 | 71 | 3H-Histamine | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 3348 | 1603 | 71 | 3H-Histamine | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 4819 | 1603 | 71 | 3H-Histamine | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 74685737 | 1603 | 71 | 3H-Histamine | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| CHEMBL914 | 1603 | 71 | 3H-Histamine | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| DB00950 | 1603 | 71 | 3H-Histamine | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 1209 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 119376 | 1811 | 41 | 3H-MEPYRAMINE | -54954 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1811 | 41 | 3H-MEPYRAMINE | -54954 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1811 | 41 | 3H-MEPYRAMINE | -54954 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | 3H-doxepin | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-doxepin | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-doxepin | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-doxepin | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-doxepin | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-doxepin | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -501 | 23 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1400 | 1926 | 64 | 3H-Histamine | 2 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 3658 | 1926 | 64 | 3H-Histamine | 2 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 7199 | 1926 | 64 | 3H-Histamine | 2 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 91513 | 1926 | 64 | 3H-Histamine | 2 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL896 | 1926 | 64 | 3H-Histamine | 2 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00557 | 1926 | 64 | 3H-Histamine | 2 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1427 | 1982 | 50 | 3H-Histamine | -5 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-Histamine | -5 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-Histamine | -5 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-Histamine | -5 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-Histamine | -5 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 1530 | 2151 | 44 | 3H-Histamine | -5 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 3827 | 2151 | 44 | 3H-Histamine | -5 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 7206 | 2151 | 44 | 3H-Histamine | -5 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| CHEMBL534 | 2151 | 44 | 3H-Histamine | -5 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| DB00920 | 2151 | 44 | 3H-Histamine | -5 | 20 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 18971832 | 2385 | 0 | 3H-PYRILAMINE | -1621 | 13 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | ||
| 21 | 2385 | 0 | 3H-PYRILAMINE | -1621 | 13 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | ||
| CHEMBL3186179 | 2385 | 0 | 3H-PYRILAMINE | -1621 | 13 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | ||
| 1227 | 2454 | 35 | 3H-Histamine | -2 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-Histamine | -2 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-Histamine | -2 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-Histamine | -2 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-Histamine | -2 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-Histamine | -2 | 11 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 134 | 2478 | 19 | 3H-PYRILAMINE | -933 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 134 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | 3H-PYRILAMINE | -933 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | 3H-PYRILAMINE | -933 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | 3H-PYRILAMINE | -933 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | 3H-PYRILAMINE | -933 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1233 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| 1548992 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| CHEMBL275446 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| DB08805 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| 1782 | 2482 | 81 | 3H-MEPYRAMINE | -676 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2482 | 81 | 3H-MEPYRAMINE | -676 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2482 | 81 | 3H-MEPYRAMINE | -676 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2482 | 81 | 3H-MEPYRAMINE | -676 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2482 | 81 | 3H-MEPYRAMINE | -676 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 135 | 2496 | 38 | 3H-Histamine | -1 | 57 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-Histamine | -1 | 57 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-Histamine | -1 | 57 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-Histamine | -1 | 57 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-Histamine | -1 | 57 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1830 | 2552 | 39 | 3H-doxepin | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 1830 | 2552 | 39 | UNDEFINED | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 207 | 2552 | 39 | 3H-doxepin | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 207 | 2552 | 39 | UNDEFINED | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 23897 | 2552 | 39 | 3H-doxepin | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 23897 | 2552 | 39 | UNDEFINED | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| CHEMBL460 | 2552 | 39 | 3H-doxepin | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| CHEMBL460 | 2552 | 39 | UNDEFINED | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| DB01618 | 2552 | 39 | 3H-doxepin | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| DB01618 | 2552 | 39 | UNDEFINED | -125 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 1890 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 4449 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 7247 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| CHEMBL623 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| DB01149 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 15897 | 2817 | 0 | 3H-PYRILAMINE | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | ||
| 215 | 2817 | 0 | 3H-PYRILAMINE | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | ||
| CHEMBL1979333 | 2817 | 0 | 3H-PYRILAMINE | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | ||
| 208 | 2820 | 0 | 3H-PYRILAMINE | -109 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 4.2 | NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 4541 | 2820 | 0 | 3H-PYRILAMINE | -109 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 4.2 | NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL1494 | 2820 | 0 | 3H-PYRILAMINE | -109 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 4.2 | NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 2142 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 2202 | 3083 | 91 | 3H-PYRILAMINE | -316 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
| 4850 | 3083 | 91 | 3H-PYRILAMINE | -316 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
| 49 | 3083 | 91 | 3H-PYRILAMINE | -316 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
| CHEMBL1371770 | 3083 | 91 | 3H-PYRILAMINE | -316 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
| DB12478 | 3083 | 91 | 3H-PYRILAMINE | -316 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | ||
| 119570 | 3110 | 90 | 3H-PYRILAMINE | -7585 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| 119570 | 3110 | 90 | 3H-PYRILAMINE | -162 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| 2233 | 3110 | 90 | 3H-PYRILAMINE | -7585 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| 2233 | 3110 | 90 | 3H-PYRILAMINE | -162 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| 953 | 3110 | 90 | 3H-PYRILAMINE | -7585 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| 953 | 3110 | 90 | 3H-PYRILAMINE | -162 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| CHEMBL301265 | 3110 | 90 | 3H-PYRILAMINE | -7585 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| CHEMBL301265 | 3110 | 90 | 3H-PYRILAMINE | -162 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| DB00413 | 3110 | 90 | 3H-PYRILAMINE | -7585 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| DB00413 | 3110 | 90 | 3H-PYRILAMINE | -162 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | ||
| 2286 | 3134 | 48 | 3H-Histamine | -2 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | 3H-Histamine | -2 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | 3H-Histamine | -2 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | 3H-Histamine | -2 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | 3H-Histamine | -2 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 165193 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 2303 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 4946 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 564 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 62882 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 63 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 66366 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 91536 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| CHEMBL27 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| CHEMBL452861 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| DB00571 | 3138 | 60 | 3H-doxepin | -660 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 243 | 3153 | 85 | 3H-PYRILAMINE | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3052762 | 3153 | 85 | 3H-PYRILAMINE | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3502 | 3153 | 85 | 3H-PYRILAMINE | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| CHEMBL117287 | 3153 | 85 | 3H-PYRILAMINE | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| DB06480 | 3153 | 85 | 3H-PYRILAMINE | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 1234 | 3239 | 0 | 3H-MEPYRAMINE | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| 1234 | 3239 | 0 | 3H-doxepin | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| 3001055 | 3239 | 0 | 3H-MEPYRAMINE | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| 3001055 | 3239 | 0 | 3H-doxepin | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| CHEMBL512 | 3239 | 0 | 3H-MEPYRAMINE | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| CHEMBL512 | 3239 | 0 | 3H-doxepin | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| DB00863 | 3239 | 0 | 3H-MEPYRAMINE | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| DB00863 | 3239 | 0 | 3H-doxepin | -162 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 10 | 2 | 7 | 1.5 | CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C | None | ||
| 128563 | 3408 | 28 | 3H-PYRILAMINE | -2398 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
| 1666 | 3408 | 28 | 3H-PYRILAMINE | -2398 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
| CHEMBL445332 | 3408 | 28 | 3H-PYRILAMINE | -2398 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
| DB12327 | 3408 | 28 | 3H-PYRILAMINE | -2398 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | ||
| 221 | 3435 | 63 | UNDEFINED | -478 | 13 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | ||
| 3277600 | 3435 | 63 | UNDEFINED | -478 | 13 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | ||
| CHEMBL323356 | 3435 | 63 | UNDEFINED | -478 | 13 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | ||
| 189 | 3436 | 31 | 3H-MEPYRAMINE | -4168 | 17 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | ||
| 5163 | 3436 | 31 | 3H-MEPYRAMINE | -4168 | 17 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | ||
| CHEMBL297784 | 3436 | 31 | 3H-MEPYRAMINE | -4168 | 17 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | ||
| 6917970 | 3635 | 54 | 3H-PYRILAMINE | -2290 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | ||
| 8370 | 3635 | 54 | 3H-PYRILAMINE | -2290 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | ||
| CHEMBL487387 | 3635 | 54 | 3H-PYRILAMINE | -2290 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | ||
| 1577 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 164512405 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 2537 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 5355 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 5501 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 643497 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 688272 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 958 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 960 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| CHEMBL196677 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| CHEMBL26 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| CHEMBL267044 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| DB00391 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| DB16021 | 3647 | 104 | 3H-MEPYRAMINE | -389 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N | None | ||
| 1267 | 3744 | 43 | 3H-MEPYRAMINE | -4168 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| 1267 | 3744 | 43 | 3H-MEPYRAMINE | -4168 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| 3035905 | 3744 | 43 | 3H-MEPYRAMINE | -4168 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| 3035905 | 3744 | 43 | 3H-MEPYRAMINE | -4168 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| CHEMBL260374 | 3744 | 43 | 3H-MEPYRAMINE | -4168 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| CHEMBL260374 | 3744 | 43 | 3H-MEPYRAMINE | -4168 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| 1235 | 3763 | 32 | 3H-doxepin | -316 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 312 | 6 | 4 | 6 | -0.1 | N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N | None | ||
| 3959 | 3763 | 32 | 3H-doxepin | -316 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 312 | 6 | 4 | 6 | -0.1 | N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N | None | ||
| 50287 | 3763 | 32 | 3H-doxepin | -316 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 312 | 6 | 4 | 6 | -0.1 | N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N | None | ||
| CHEMBL269646 | 3763 | 32 | 3H-doxepin | -316 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 312 | 6 | 4 | 6 | -0.1 | N#CNC(=NC)NCCSCc1csc(n1)N=C(N)N | None | ||
| 2762 | 3802 | 28 | 3H-Histamine | -9 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 5587 | 3802 | 28 | 3H-Histamine | -9 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 7318 | 3802 | 28 | 3H-Histamine | -9 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| CHEMBL1241 | 3802 | 28 | 3H-Histamine | -9 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| DB00792 | 3802 | 28 | 3H-Histamine | -9 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 1228 | 3805 | 31 | 3H-Histamine | -5 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-Histamine | -5 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-Histamine | -5 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-Histamine | -5 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-Histamine | -5 | 4 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 46882224 | 6271 | 0 | UNDEFINED | -354 | 5 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 543 | 10 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1 | None | ||
| CHEMBL1082036 | 6271 | 0 | UNDEFINED | -354 | 5 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 543 | 10 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)cc(OC2CCOCC2)c1 | None | ||
| 2662 | 11279 | 124 | 3H-PYRILAMINE | -41 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | ||
| CHEMBL118 | 11279 | 124 | 3H-PYRILAMINE | -41 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | ||
| 3032915 | 15321 | 20 | 3H-MEPYRAMINE | -169 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 212 | 5 | 3 | 2 | 1.2 | C/N=C(\S)NCCCCc1c[nH]cn1 | None | ||
| CHEMBL12160 | 15321 | 20 | 3H-MEPYRAMINE | -169 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 212 | 5 | 3 | 2 | 1.2 | C/N=C(\S)NCCCCc1c[nH]cn1 | None | ||
| 10297 | 26905 | 29 | 3H-PYRILAMINE | -38 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | ||
| CHEMBL136560 | 26905 | 29 | 3H-PYRILAMINE | -38 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | ||
| 156391 | 46537 | 95 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | ||
| CHEMBL1200806 | 46537 | 95 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | ||
| CHEMBL154 | 46537 | 95 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | ||
| 10624 | 69957 | 17 | 3H-PYRILAMINE | -102 | 32 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
| 10624 | 69957 | 17 | 3H-MEPYRAMINE | -102 | 32 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
| 138543650 | 69957 | 17 | 3H-PYRILAMINE | -102 | 32 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
| 138543650 | 69957 | 17 | 3H-MEPYRAMINE | -102 | 32 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
| CHEMBL194378 | 69957 | 17 | 3H-PYRILAMINE | -102 | 32 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
| CHEMBL194378 | 69957 | 17 | 3H-MEPYRAMINE | -102 | 32 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | ||
| 54477 | 84230 | 34 | 3H-MEPYRAMINE | -70 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
| 54477 | 84230 | 34 | 3H-PYRILAMINE | -70 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
| CHEMBL22242 | 84230 | 34 | 3H-MEPYRAMINE | -70 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
| CHEMBL22242 | 84230 | 34 | 3H-PYRILAMINE | -70 | 22 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
| 2244 | 93798 | 96 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | ||
| CHEMBL25 | 93798 | 96 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | ||
| 104870 | 98423 | 39 | 3H-PYRILAMINE | -549 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
| 5374 | 98423 | 39 | 3H-PYRILAMINE | -549 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
| CHEMBL279085 | 98423 | 39 | 3H-PYRILAMINE | -549 | 21 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | ||
| 3663 | 99505 | 79 | 3H-PYRILAMINE | -288 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | None | ||
| CHEMBL286494 | 99505 | 79 | 3H-PYRILAMINE | -288 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | None | ||
| 3452843 | 119020 | 13 | 3H-PYRILAMINE | -1 | 10 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | None | ||
| CHEMBL345686 | 119020 | 13 | 3H-PYRILAMINE | -1 | 10 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | None | ||
| 44208932 | 140176 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| CHEMBL381689 | 140176 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| 4595 | 176141 | 102 | 3H-MEPYRAMINE | -186 | 15 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | ||
| CHEMBL46 | 176141 | 102 | 3H-MEPYRAMINE | -186 | 15 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | ||
| 43815 | 186337 | 58 | 3H-PYRILAMINE | -1995 | 24 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| 43815 | 186337 | 58 | 3H-PYRILAMINE | -1995 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| 43815 | 186337 | 58 | 3H-MEPYRAMINE | -1995 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| CHEMBL1708 | 186337 | 58 | 3H-PYRILAMINE | -1995 | 24 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| CHEMBL1708 | 186337 | 58 | 3H-PYRILAMINE | -1995 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| CHEMBL1708 | 186337 | 58 | 3H-MEPYRAMINE | -1995 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| CHEMBL490 | 186337 | 58 | 3H-PYRILAMINE | -1995 | 24 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| CHEMBL490 | 186337 | 58 | 3H-PYRILAMINE | -1995 | 24 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| CHEMBL490 | 186337 | 58 | 3H-MEPYRAMINE | -1995 | 24 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
| 5280343 | 187691 | 119 | 3H-PYRILAMINE | -147 | 32 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
| CHEMBL1520590 | 187691 | 119 | 3H-PYRILAMINE | -147 | 32 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
| CHEMBL50 | 187691 | 119 | 3H-PYRILAMINE | -147 | 32 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | ||
| 12016890 | 190182 | 4 | 3H-PYRILAMINE | -16982 | 10 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 4 | 1 | 3 | 2.6 | NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2 | None | ||
| CHEMBL5183389 | 190182 | 4 | 3H-PYRILAMINE | -16982 | 10 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 4 | 1 | 3 | 2.6 | NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2 | None | ||
| 54676228 | 192874 | 108 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | ||
| CHEMBL527 | 192874 | 108 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | ||
| 4495 | 194860 | 87 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | ||
| CHEMBL56367 | 194860 | 87 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | ||
| 54677470 | 198867 | 110 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | ||
| CHEMBL1256873 | 198867 | 110 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | ||
| CHEMBL599 | 198867 | 110 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | ||
| 162265 | 200587 | 19 | 3H-PYRILAMINE | -239 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | ||
| 4786 | 200587 | 19 | 3H-PYRILAMINE | -239 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | ||
| CHEMBL61006 | 200587 | 19 | 3H-PYRILAMINE | -239 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | ||
| 5281600 | 201336 | 85 | 3H-PYRILAMINE | -275 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | ||
| CHEMBL63354 | 201336 | 85 | 3H-PYRILAMINE | -275 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | ||
| 5656 | 201377 | 82 | 3H-PYRILAMINE | -79 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| 5656 | 201377 | 82 | 3H-PYRILAMINE | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| 5656 | 201377 | 82 | 3H-MEPYRAMINE | -79 | 40 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| CHEMBL637 | 201377 | 82 | 3H-PYRILAMINE | -79 | 40 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| CHEMBL637 | 201377 | 82 | 3H-PYRILAMINE | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| CHEMBL637 | 201377 | 82 | 3H-MEPYRAMINE | -79 | 40 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| 1238 | 201484 | 21 | 3H-Histamine | -38 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
| CHEMBL64249 | 201484 | 21 | 3H-Histamine | -38 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
| 1973 | 201790 | 12 | 3H-PYRILAMINE | -3 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| CHEMBL1394464 | 201790 | 12 | 3H-PYRILAMINE | -3 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| CHEMBL66089 | 201790 | 12 | 3H-PYRILAMINE | -3 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| 2118 | 201792 | 35 | 3H-doxepin | -24 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 1 | 0 | 4 | 3.6 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 | None | ||
| CHEMBL661 | 201792 | 35 | 3H-doxepin | -24 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 1 | 0 | 4 | 3.6 | Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 | None | ||
| 3291 | 202302 | 72 | 3H-doxepin | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 141 | 1 | 1 | 2 | 0.4 | CCC1(C)CC(=O)NC1=O | None | ||
| CHEMBL696 | 202302 | 72 | 3H-doxepin | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 141 | 1 | 1 | 2 | 0.4 | CCC1(C)CC(=O)NC1=O | None | ||
| 2995 | 202700 | 49 | 3H-Histamine | -14 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-Histamine | -14 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-Histamine | -14 | 22 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 4054 | 203790 | 64 | 3H-PYRILAMINE | -1 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | ||
| CHEMBL1699 | 203790 | 64 | 3H-PYRILAMINE | -1 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | ||
| CHEMBL807 | 203790 | 64 | 3H-PYRILAMINE | -1 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | ||
| 68617 | 203816 | 60 | 3H-PYRILAMINE | -1023 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| 68617 | 203816 | 60 | 3H-MEPYRAMINE | -1445 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL1709 | 203816 | 60 | 3H-PYRILAMINE | -1023 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL1709 | 203816 | 60 | 3H-MEPYRAMINE | -1445 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL809 | 203816 | 60 | 3H-PYRILAMINE | -1023 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL809 | 203816 | 60 | 3H-MEPYRAMINE | -1445 | 25 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| 5324346 | 203870 | 53 | 3H-PYRILAMINE | -1 | 9 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 9 | 1 | 4 | 3.2 | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 | None | ||
| 5324346 | 203870 | 53 | 3H-MEPYRAMINE | -1 | 9 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 9 | 1 | 4 | 3.2 | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 | None | ||
| CHEMBL1409 | 203870 | 53 | 3H-PYRILAMINE | -1 | 9 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 9 | 1 | 4 | 3.2 | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 | None | ||
| CHEMBL1409 | 203870 | 53 | 3H-MEPYRAMINE | -1 | 9 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 9 | 1 | 4 | 3.2 | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 | None | ||
| CHEMBL814 | 203870 | 53 | 3H-PYRILAMINE | -1 | 9 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 9 | 1 | 4 | 3.2 | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 | None | ||
| CHEMBL814 | 203870 | 53 | 3H-MEPYRAMINE | -1 | 9 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 318 | 9 | 1 | 4 | 3.2 | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 | None | ||
| 16231 | 205776 | 53 | 3H-MEPYRAMINE | -7 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 5 | 6 | -1.1 | N=C(N)NC(=O)c1nc(Cl)c(N)nc1N | None | ||
| CHEMBL945 | 205776 | 53 | 3H-MEPYRAMINE | -7 | 16 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 229 | 1 | 5 | 6 | -1.1 | N=C(N)NC(=O)c1nc(Cl)c(N)nc1N | None | ||
| 11954224 | 214174 | 0 | 3H-PYRILAMINE | -141253 | 59 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | ||
| None | 214179 | 0 | 3H-MEPYRAMINE | -63095 | 19 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 421 | 9 | 1 | 6 | 4.3 | COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 | None | ||
| 25058166 | 214181 | 0 | 3H-PYRILAMINE | -5011 | 26 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
| 6852389 | 214181 | 0 | 3H-PYRILAMINE | -5011 | 26 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | ||
| 44134711 | 214215 | 0 | 3H-MEPYRAMINE | -112201 | 13 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 340 | 6 | 2 | 4 | 2.8 | CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl | None | ||
| None | 214217 | 0 | 3H-PYRILAMINE | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 2 | 0 | 4 | 3.6 | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl | None | ||
| 4528 | 214218 | 0 | 3H-Histamine | -7 | 9 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 238 | 1 | 1 | 2 | 2.8 | CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3 | None | ||
| 444 | 214245 | 0 | 3H-PYRILAMINE | -2089 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 239 | 3 | 1 | 2 | 3.3 | CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C | None | ||
| 104911 | 214249 | 0 | 3H-PYRILAMINE | -41686 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | ||
| 104911 | 214249 | 0 | 3H-PYRILAMINE | -41686 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | ||
| 131632304 | 214266 | 0 | 3H-MEPYRAMINE | -70794 | 13 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 303 | 4 | 1 | 5 | 0.9 | CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4 | None | ||
| 119380 | 214359 | 0 | 3H-PYRILAMINE | -1 | 8 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 166 | 1 | 0 | 3 | 1.8 | CC1=NOC(=C1)C2CCCN2C | None | ||
| 37632 | 214375 | 0 | 3H-PYRILAMINE | -1 | 8 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 3 | 0 | 5 | 3.3 | CN(C)CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4 | None | ||
| None | 214392 | 0 | 3H-doxepin | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 281 | 2 | 1 | 4 | 2.4 | C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3 | None | ||
| 4737 | 214393 | 0 | 3H-doxepin | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 226 | 4 | 2 | 3 | 1.2 | CCCC(C)C1(C(=O)NC(=O)NC1=O)CC | None | ||
| None | 214394 | 0 | 3H-doxepin | 1 | 2 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 1 | 0 | 7 | 2.6 | CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3 | None | ||
| 3380 | 214422 | 0 | 3H-MEPYRAMINE | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 2 | 0 | 4 | 2.5 | CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F | None | ||
| 25137849 | 214425 | 0 | 3H-PYRILAMINE | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | ||
| 71290 | 214425 | 0 | 3H-PYRILAMINE | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | ||
| 3337 | 214441 | 0 | 3H-PYRILAMINE | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
| 65801 | 214441 | 0 | 3H-PYRILAMINE | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
| 66264 | 214441 | 0 | 3H-PYRILAMINE | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
| 91452 | 214441 | 0 | 3H-PYRILAMINE | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)CC1=CC(=CC=C1)C(F)(F)F | None | ||
| None | 214497 | 0 | 3H-MEPYRAMINE | -501 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 468 | 12 | 0 | 9 | -0.1 | C1COCCN1CCCN2CN(CN(C2)CCCN3CCOCC3)CCCN4CCOCC4 | None | ||
| None | 214498 | 0 | 3H-MEPYRAMINE | -1258 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 434 | 6 | 4 | 8 | 2.2 | CC(C)O.COC1=C(C=CC(=C1)CC2COC(=O)C2(CC3=CC(=C(C=C3)O)OC)O)O | None | ||
| None | 214499 | 0 | 3H-MEPYRAMINE | -3981 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 234 | 2 | 1 | 3 | 2.0 | CC(=O)NC1=C(C(=C(C=C1F)F)F)[N+](=O)[O-] | None | ||
| None | 214500 | 0 | 3H-MEPYRAMINE | -4677 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 0 | 1 | 2 | 4.0 | CC12CCC(CC1CCC3C2CCC4(C3CCC4=O)C)(C#C)O | None | ||
| None | 214501 | 0 | 3H-MEPYRAMINE | -6025 | 3 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 5 | 1 | 3 | 4.5 | CCCC1=CC2=C(C=C1NC(=O)C3C(C3(C)C)C=C(C)C)OCO2 | None | ||
| 3821 | 214549 | 0 | 3H-PYRILAMINE | -1 | 18 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(CCCCC1=O)C2=CC=CC=C2Cl | None | ||
| None | 214560 | 0 | 3H-PYRILAMINE | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 240 | 7 | 4 | 6 | -0.8 | C(C(C(=O)O)N)SSCC(C(=O)O)N | None | ||
| None | 214560 | 0 | 3H-PYRILAMINE | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 240 | 7 | 4 | 6 | -0.8 | C(C(C(=O)O)N)SSCC(C(=O)O)N | None | ||
| None | 214561 | 0 | 3H-PYRILAMINE | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 4 | 2 | 3 | 0.2 | CSCCC(C(=O)O)N | None | ||
| None | 214561 | 0 | 3H-PYRILAMINE | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 4 | 2 | 3 | 0.2 | CSCCC(C(=O)O)N | None | ||
| None | 214562 | 0 | 3H-PYRILAMINE | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 135 | 3 | 3 | 3 | -0.3 | C(CS)C(C(=O)O)N | None | ||
| None | 214562 | 0 | 3H-PYRILAMINE | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 135 | 3 | 3 | 3 | -0.3 | C(CS)C(C(=O)O)N | None | ||
| None | 214563 | 0 | 3H-PYRILAMINE | -1 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 3 | 3 | -0.7 | C(C(C(=O)O)N)S | None | ||
| None | 214563 | 0 | 3H-PYRILAMINE | -1 | 33 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 121 | 2 | 3 | 3 | -0.7 | C(C(C(=O)O)N)S | None | ||
| None | 214564 | 0 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 117 | 0 | 1 | 3 | -0.0 | C1CSC(=O)C1N | None | ||
| None | 214565 | 0 | 3H-PYRILAMINE | -1 | 39 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 3 | 3 | 3 | -1.4 | C(C(C(=O)O)N)S(=O)O | None | ||
| None | 214565 | 0 | 3H-PYRILAMINE | -1 | 39 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 153 | 3 | 3 | 3 | -1.4 | C(C(C(=O)O)N)S(=O)O | None | ||
| None | 214566 | 0 | 3H-PYRILAMINE | -1 | 38 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 3 | 3 | 4 | -1.7 | C(C(C(=O)O)N)S(=O)(=O)O | None | ||
| None | 214566 | 0 | 3H-PYRILAMINE | -1 | 38 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 169 | 3 | 3 | 4 | -1.7 | C(C(C(=O)O)N)S(=O)(=O)O | None | ||
| None | 214567 | 0 | 3H-PYRILAMINE | -1 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 183 | 4 | 3 | 4 | -1.3 | C(CS(=O)(=O)O)C(C(=O)O)N | None | ||
| None | 214574 | 0 | 3H-PYRILAMINE | -13 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.2 | CC(C(=O)C1=CC=CC=C1)N | None | ||
| 1576 | 214575 | 0 | 3H-PYRILAMINE | -16 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 163 | 3 | 1 | 2 | 1.5 | CC(C(=O)C1=CC=CC=C1)NC | None | ||
| None | 214576 | 0 | 3H-PYRILAMINE | -16 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 536 | 11 | 1 | 4 | 9.0 | CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C | None | ||
| 4978 | 214577 | 0 | 3H-PYRILAMINE | -16 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 1 | 7 | 9 | 4.3 | CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O | None | ||
| None | 214578 | 0 | 3H-PYRILAMINE | -3 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 464 | 4 | 8 | 12 | -0.6 | C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O | None | ||
| None | 214579 | 0 | 3H-PYRILAMINE | -281 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 610 | 6 | 10 | 16 | -1.7 | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O | None | ||
| None | 214580 | 0 | 3H-PYRILAMINE | -1 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 448 | 3 | 7 | 11 | 0.4 | CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O | None | ||
| None | 214638 | 0 | 3H-PYRILAMINE | 1 | 2 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 313 | 5 | 1 | 3 | 3.5 | CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl | None | ||
| 135269 | 214639 | 0 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 222 | 5 | 1 | 3 | 2.5 | CCCCC(=O)OC1=CC=CC=C1C(=O)O | None | ||
| 5018304 | 214641 | 0 | 3H-PYRILAMINE | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 317 | 4 | 1 | 3 | 0.0 | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] | None | ||
| 3672 | 214642 | 0 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)CC1=CC=C(C=C1)C(C)C(=O)O | None | ||
| 84003 | 214643 | 0 | 3H-PYRILAMINE | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 376 | 6 | 5 | 7 | -0.0 | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O | None | ||
| 119828 | 214645 | 0 | 3H-PYRILAMINE | -1 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 5 | 1 | 5 | 3.5 | CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C | None | ||
| 119607 | 214647 | 0 | 3H-PYRILAMINE | -97 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N | None | ||
| None | 214648 | 0 | 3H-PYRILAMINE | -7 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 517 | 8 | 2 | 5 | 5.2 | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C | None | ||
| None | 214703 | 0 | UNDEFINED | -660 | 27 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | ||
| None | 214703 | 0 | Functional | -660 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | ||
| None | 214747 | 0 | 3H-PYRILAMINE | -4570 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 347 | 6 | 0 | 3 | 5.0 | CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 | None | ||
| None | 214752 | 0 | 3H-PYRILAMINE | -10471285 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 372 | 2 | 1 | 3 | 4.4 | CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl | None | ||
| None | 214753 | 0 | 3H-Strychnine | -1 | 13 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 399 | 7 | 4 | 5 | 1.8 | CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O | None | ||
| 1233 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 4.0 | pKi | = | 4 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| 1548992 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 4.0 | pKi | = | 4 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| CHEMBL275446 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 4.0 | pKi | = | 4 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| DB08805 | 2479 | 0 | 3H-MEPYRAMINE | -19 | 3 | Rat | 4.0 | pKi | = | 4 | Binding | PDSP KiDatabase | 244 | 5 | 3 | 3 | 1.0 | CNC(=S)NCCSCc1nc[nH]c1C | None | ||
| 3036864 | 201066 | 16 | 3H-MEPYRAMINE | -416 | 27 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
| CHEMBL1256645 | 201066 | 16 | 3H-MEPYRAMINE | -416 | 27 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
| CHEMBL1814790 | 201066 | 16 | 3H-MEPYRAMINE | -416 | 27 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
| CHEMBL62 | 201066 | 16 | 3H-MEPYRAMINE | -416 | 27 | Human | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | ||
| 46882664 | 5641 | 0 | UNDEFINED | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 494 | 8 | 2 | 8 | 3.6 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC | None | ||
| CHEMBL1078240 | 5641 | 0 | UNDEFINED | -2 | 5 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 494 | 8 | 2 | 8 | 3.6 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1OC | None | ||
| 11545813 | 180612 | 0 | UNDEFINED | -24 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | None | ||
| CHEMBL476109 | 180612 | 0 | UNDEFINED | -24 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 400 | 6 | 0 | 3 | 5.2 | O=C(CCCN1C2CCC1CN(c1ccc(Cl)cc1)CC2)c1ccc(F)cc1 | None | ||
| 21830793 | 91403 | 5 | 3H-8-OH-DPAT | -6760 | 46 | Bovine | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | ||
| CHEMBL2413154 | 91403 | 5 | 3H-8-OH-DPAT | -6760 | 46 | Bovine | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | ||
| 2 | 3210 | 19 | 3H-PYRILAMINE | -218 | 28 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
| 54562 | 3210 | 19 | 3H-PYRILAMINE | -218 | 28 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
| CHEMBL240773 | 3210 | 19 | 3H-PYRILAMINE | -218 | 28 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | ||
| None | 214591 | 0 | 3H-PYRILAMINE | -194 | 19 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 246 | 2 | 1 | 4 | 1.6 | CCCN1CCCC2C1CC3=CN=C(N=C3C2)N | None | ||
| 1427 | 1982 | 50 | 3H-MEPYRAMINE | -5 | 26 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-MEPYRAMINE | -5 | 26 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-MEPYRAMINE | -5 | 26 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-MEPYRAMINE | -5 | 26 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-MEPYRAMINE | -5 | 26 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Rat | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 1224 | 1404 | 79 | 3H-trans-H2-PAT,(-) | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-trans-H2-PAT,(-) | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-trans-H2-PAT,(-) | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-trans-H2-PAT,(-) | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-trans-H2-PAT,(-) | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-trans-H2-PAT,(-) | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 1209 | 1628 | 69 | 3H-doxepin | -144 | 31 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | 3H-doxepin | -144 | 31 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | 3H-doxepin | -144 | 31 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | 3H-doxepin | -144 | 31 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | 3H-doxepin | -144 | 31 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 213 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 2717 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 5533 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| CHEMBL621 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| DB00656 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1222 | 1634 | 44 | 3H-PYRILAMINE | -17 | 32 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3396 | 1634 | 44 | 3H-PYRILAMINE | -17 | 32 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 85 | 1634 | 44 | 3H-PYRILAMINE | -17 | 32 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL46516 | 1634 | 44 | 3H-PYRILAMINE | -17 | 32 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| DB04842 | 1634 | 44 | 3H-PYRILAMINE | -17 | 32 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 11954259 | 214201 | 0 | 3H-PYRILAMINE | -19 | 43 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
| 3294 | 1975 | 106 | 3H-PYRILAMINE | -14 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 71360 | 1975 | 106 | 3H-PYRILAMINE | -14 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 87 | 1975 | 106 | 3H-PYRILAMINE | -14 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| CHEMBL14376 | 1975 | 106 | 3H-PYRILAMINE | -14 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| DB04946 | 1975 | 106 | 3H-PYRILAMINE | -14 | 44 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 1222 | 868 | 0 | 3H-MEPYRAMINE | 1 | 2 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | 3H-MEPYRAMINE | 1 | 2 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | 3H-MEPYRAMINE | 1 | 2 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | 3H-MEPYRAMINE | 1 | 2 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | 3H-MEPYRAMINE | 1 | 2 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 100 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2995 | 202700 | 49 | 3H-doxepin | -14 | 22 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-doxepin | -14 | 22 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-doxepin | -14 | 22 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 21722 | 214239 | 0 | 3H-doxepin | 1 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 2 | 4.3 | CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31 | None | ||
| 16667681 | 214389 | 0 | 3H-doxepin | 4 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 45485525 | 196122 | 0 | UNDEFINED | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 337 | 7 | 1 | 2 | 4.8 | Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL572034 | 196122 | 0 | UNDEFINED | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 337 | 7 | 1 | 2 | 4.8 | Cc1ccc(CCCCN2CCC(C(O)c3ccccc3)CC2)cc1 | None | ||
| 2995 | 202700 | 49 | 3H-PYRILAMINE | -42 | 22 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-PYRILAMINE | -42 | 22 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-PYRILAMINE | -42 | 22 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 12057539 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 219050 | 3321 | 21 | 3H-PYRILAMINE | -794 | 21 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | ||
| 52 | 3321 | 21 | 3H-PYRILAMINE | -794 | 21 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | ||
| CHEMBL431367 | 3321 | 21 | 3H-PYRILAMINE | -794 | 21 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | ||
| 2444 | 214416 | 0 | 3H-MEPYRAMINE | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 333 | 6 | 0 | 2 | 4.1 | CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 2435 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 60149 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 98 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| CHEMBL12713 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| DB06144 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 2865 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 37459 | 735 | 10 | 3H-MEPYRAMINE | -3019 | 24 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 62 | 735 | 10 | 3H-MEPYRAMINE | -3019 | 24 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| CHEMBL8514 | 735 | 10 | 3H-MEPYRAMINE | -3019 | 24 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 1621 | 2396 | 16 | 3H-MEPYRAMINE | -4570 | 44 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 17 | 2396 | 16 | 3H-MEPYRAMINE | -4570 | 44 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 5761 | 2396 | 16 | 3H-MEPYRAMINE | -4570 | 44 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL263881 | 2396 | 16 | 3H-MEPYRAMINE | -4570 | 44 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB04829 | 2396 | 16 | 3H-MEPYRAMINE | -4570 | 44 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 46882180 | 5764 | 0 | UNDEFINED | -5 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 482 | 7 | 2 | 7 | 3.7 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F | None | ||
| CHEMBL1079180 | 5764 | 0 | UNDEFINED | -5 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 482 | 7 | 2 | 7 | 3.7 | CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F | None | ||
| None | 214590 | 0 | 3H-PYRILAMINE | -1819 | 19 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 451 | 8 | 2 | 4 | 3.2 | CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C | None | ||
| 135398737 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 100 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 1224 | 1404 | 79 | UNDEFINED | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | UNDEFINED | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | UNDEFINED | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | UNDEFINED | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | UNDEFINED | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | UNDEFINED | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 9906978 | 42466 | 1 | UNDEFINED | -28 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
| CHEMBL150161 | 42466 | 1 | UNDEFINED | -28 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
| 37459 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 62 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| CHEMBL8514 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 1210 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 2865 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 4543 | 169982 | 36 | 3H-MEPYRAMINE | -1 | 29 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | 3H-MEPYRAMINE | -1 | 29 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | 3H-MEPYRAMINE | -1 | 29 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 1204 | 1901 | 114 | 3H-Histamine | -501 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-Histamine | -501 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-Histamine | -501 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-Histamine | -501 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-Histamine | -501 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-Histamine | -501 | 23 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 11957566 | 183 | 20 | 3H-MEPYRAMINE | -812 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | None | ||
| 1219 | 183 | 20 | 3H-MEPYRAMINE | -812 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | None | ||
| 3296 | 183 | 20 | 3H-MEPYRAMINE | -812 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | None | ||
| 950 | 183 | 20 | 3H-MEPYRAMINE | -812 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | None | ||
| CHEMBL285755 | 183 | 20 | 3H-MEPYRAMINE | -812 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)cc(cc2)O)CCC | None | ||
| 2142 | 3047 | 54 | 3H-MEPYRAMINE | -263 | 36 | Human | 4.8 | pKi | = | 4.8 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | 3H-MEPYRAMINE | -263 | 36 | Human | 4.8 | pKi | = | 4.8 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | 3H-MEPYRAMINE | -263 | 36 | Human | 4.8 | pKi | = | 4.8 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | 3H-MEPYRAMINE | -263 | 36 | Human | 4.8 | pKi | = | 4.8 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | 3H-MEPYRAMINE | -263 | 36 | Human | 4.8 | pKi | = | 4.8 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | 3H-MEPYRAMINE | -263 | 36 | Human | 4.8 | pKi | = | 4.8 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 1621 | 2396 | 16 | 3H-PYRILAMINE | -4570 | 44 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 17 | 2396 | 16 | 3H-PYRILAMINE | -4570 | 44 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 5761 | 2396 | 16 | 3H-PYRILAMINE | -4570 | 44 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL263881 | 2396 | 16 | 3H-PYRILAMINE | -4570 | 44 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB04829 | 2396 | 16 | 3H-PYRILAMINE | -4570 | 44 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 1209 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 45485535 | 195944 | 0 | UNDEFINED | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 399 | 7 | 1 | 2 | 5.6 | Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL570695 | 195944 | 0 | UNDEFINED | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 399 | 7 | 1 | 2 | 5.6 | Cc1ccc(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 44395741 | 180999 | 0 | UNDEFINED | -10 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
| CHEMBL476935 | 180999 | 0 | UNDEFINED | -10 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
| CHEMBL558392 | 180999 | 0 | UNDEFINED | -10 | 10 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 360 | 6 | 0 | 3 | 4.3 | O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
| 1001 | 613 | 91 | 3H-MEPYRAMINE | -3 | 2 | Human | 3.8 | pKi | = | 3.8 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| 2144 | 613 | 91 | 3H-MEPYRAMINE | -3 | 2 | Human | 3.8 | pKi | = | 3.8 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| CHEMBL610 | 613 | 91 | 3H-MEPYRAMINE | -3 | 2 | Human | 3.8 | pKi | = | 3.8 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| DB04325 | 613 | 91 | 3H-MEPYRAMINE | -3 | 2 | Human | 3.8 | pKi | = | 3.8 | Binding | PDSP KiDatabase | 121 | 2 | 1 | 1 | 1.2 | NCCc1ccccc1 | None | ||
| 1427 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 1427 | 1982 | 50 | 3H-doxepin | -5 | 26 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-doxepin | -5 | 26 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-doxepin | -5 | 26 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-doxepin | -5 | 26 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-doxepin | -5 | 26 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 100 | 3745 | 52 | 3H-doxepin | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-doxepin | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-doxepin | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-doxepin | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-doxepin | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 44622869 | 196040 | 0 | UNDEFINED | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 371 | 5 | 1 | 2 | 5.1 | Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL571390 | 196040 | 0 | UNDEFINED | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 371 | 5 | 1 | 2 | 5.1 | Cc1ccc(CN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 100 | 3745 | 52 | UNDEFINED | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | UNDEFINED | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | UNDEFINED | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | UNDEFINED | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | UNDEFINED | -7 | 55 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -331 | 67 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 12057539 | 206301 | 39 | 3H-doxepin | -676 | 20 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | 3H-doxepin | -676 | 20 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | 3H-doxepin | -676 | 20 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 186 | 1777 | 47 | 3H-PYRILAMINE | -213 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| 71781 | 1777 | 47 | 3H-PYRILAMINE | -213 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| CHEMBL18972 | 1777 | 47 | 3H-PYRILAMINE | -213 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | ||
| 2105 | 3005 | 34 | 3H-PYRILAMINE | -2754 | 33 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| 47811 | 3005 | 34 | 3H-PYRILAMINE | -2754 | 33 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| 48 | 3005 | 34 | 3H-PYRILAMINE | -2754 | 33 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| CHEMBL531 | 3005 | 34 | 3H-PYRILAMINE | -2754 | 33 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| DB01186 | 3005 | 34 | 3H-PYRILAMINE | -2754 | 33 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | ||
| 135398737 | 944 | 89 | UNDEFINED | -4 | 91 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | UNDEFINED | -4 | 91 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | UNDEFINED | -4 | 91 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | UNDEFINED | -4 | 91 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | UNDEFINED | -4 | 91 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | -1 | 13 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | -1 | 13 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | -1 | 13 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | -1 | 13 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | -1 | 13 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | -1 | 13 | Rat | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 1353 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| None | 214502 | 0 | 3H-MEPYRAMINE | -1412 | 18 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 416 | 9 | 3 | 4 | 2.8 | C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I | None | ||
| None | 214216 | 0 | 3H-PYRILAMINE | -1 | 10 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 522 | 10 | 0 | 3 | 6.2 | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 2274 | 3124 | 53 | UNDEFINED | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4917 | 3124 | 53 | UNDEFINED | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 7279 | 3124 | 53 | UNDEFINED | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL728 | 3124 | 53 | UNDEFINED | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00433 | 3124 | 53 | UNDEFINED | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 12057539 | 206301 | 39 | 3H-MEPYRAMINE | -3388 | 20 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | 3H-MEPYRAMINE | -3388 | 20 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | 3H-MEPYRAMINE | -3388 | 20 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 214 | 3799 | 52 | 3H-MEPYRAMINE | -218 | 29 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2740 | 3799 | 52 | 3H-MEPYRAMINE | -218 | 29 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5566 | 3799 | 52 | 3H-MEPYRAMINE | -218 | 29 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 66064 | 3799 | 52 | 3H-MEPYRAMINE | -218 | 29 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL422 | 3799 | 52 | 3H-MEPYRAMINE | -218 | 29 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00831 | 3799 | 52 | 3H-MEPYRAMINE | -218 | 29 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 11653679 | 180609 | 1 | UNDEFINED | -28 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
| CHEMBL476108 | 180609 | 1 | UNDEFINED | -28 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 374 | 6 | 0 | 3 | 4.7 | O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | None | ||
| 1353 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1212 | 1632 | 45 | 3H-MEPYRAMINE | -38 | 65 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-MEPYRAMINE | -38 | 65 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-MEPYRAMINE | -38 | 65 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-MEPYRAMINE | -38 | 65 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-MEPYRAMINE | -38 | 65 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2274 | 3124 | 53 | 3H-doxepin | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4917 | 3124 | 53 | 3H-doxepin | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 7279 | 3124 | 53 | 3H-doxepin | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL728 | 3124 | 53 | 3H-doxepin | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00433 | 3124 | 53 | 3H-doxepin | -3 | 32 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | -1 | 62 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 2389 | 3279 | 114 | UNDEFINED | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | UNDEFINED | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | UNDEFINED | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | UNDEFINED | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | UNDEFINED | -44 | 67 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 100 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-PYRILAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 1204 | 1901 | 114 | Functional | -501 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | Functional | -501 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | Functional | -501 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | Functional | -501 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | Functional | -501 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | Functional | -501 | 23 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| None | 215395 | 0 | UNDEFINED | -58 | 11 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 116 | 4 | 0 | 2 | 1.4 | CCCCN(C)N=O | None | ||
| 1353 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-doxepin | -489 | 85 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 2771 | 193347 | 67 | 3H-PYRILAMINE | -2 | 26 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | 3H-PYRILAMINE | -2 | 26 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | 3H-PYRILAMINE | -2 | 26 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 2771 | 193347 | 67 | 3H-PYRILAMINE | -9 | 26 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | 3H-PYRILAMINE | -9 | 26 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | 3H-PYRILAMINE | -9 | 26 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 46882181 | 5605 | 0 | UNDEFINED | 1 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 536 | 10 | 2 | 8 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC | None | ||
| CHEMBL1077908 | 5605 | 0 | UNDEFINED | 1 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 536 | 10 | 2 | 8 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NS(=O)(=O)c5ccccc5)ccc4o3)CC2)ccc1OC | None | ||
| 135398737 | 944 | 89 | 3H-Histamine | 2 | 91 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-Histamine | 2 | 91 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-Histamine | 2 | 91 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-Histamine | 2 | 91 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-Histamine | 2 | 91 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1400 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 3658 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 7199 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 91513 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL896 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00557 | 1926 | 64 | 3H-MEPYRAMINE | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1427 | 1982 | 50 | 3H-PYRILAMINE | -1 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-PYRILAMINE | -1 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-PYRILAMINE | -1 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-PYRILAMINE | -1 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-PYRILAMINE | -1 | 26 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 2284 | 3133 | 27 | 3H-doxepin | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 2284 | 3133 | 27 | UNDEFINED | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | 3H-doxepin | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | UNDEFINED | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | 3H-doxepin | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | UNDEFINED | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | 3H-doxepin | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | UNDEFINED | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | 3H-doxepin | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | UNDEFINED | 1 | 28 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 2600 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 2608 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 5405 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| CHEMBL17157 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| DB00342 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 46780481 | 107045 | 18 | 3H-PYRILAMINE | -11 | 53 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 9903970 | 107045 | 18 | 3H-PYRILAMINE | -11 | 53 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3187365 | 107045 | 18 | 3H-PYRILAMINE | -11 | 53 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3544974 | 107045 | 18 | 3H-PYRILAMINE | -11 | 53 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 135398737 | 944 | 89 | 3H-trans-H2-PAT,(-) | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-trans-H2-PAT,(-) | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-trans-H2-PAT,(-) | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-trans-H2-PAT,(-) | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-trans-H2-PAT,(-) | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 2564 | 214414 | 0 | 3H-MEPYRAMINE | 2 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 290 | 6 | 0 | 3 | 3.4 | CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 | None | ||
| None | 214419 | 0 | 3H-MEPYRAMINE | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 296 | 2 | 0 | 3 | 4.2 | CN1CCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42 | None | ||
| 135398737 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 2284 | 3133 | 27 | 3H-MEPYRAMINE | -1 | 28 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | 3H-MEPYRAMINE | -1 | 28 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | 3H-MEPYRAMINE | -1 | 28 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | 3H-MEPYRAMINE | -1 | 28 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | 3H-MEPYRAMINE | -1 | 28 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 1227 | 2454 | 35 | 3H-PYRILAMINE | -2 | 11 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-PYRILAMINE | -2 | 11 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-PYRILAMINE | -2 | 11 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-PYRILAMINE | -2 | 11 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-PYRILAMINE | -2 | 11 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-PYRILAMINE | -2 | 11 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1210 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 16667681 | 214389 | 0 | 3H-MEPYRAMINE | 4 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 2286 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | 3H-MEPYRAMINE | -2 | 29 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -50 | 67 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -50 | 67 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -50 | 67 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -50 | 67 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -50 | 67 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 1210 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-trans-H2-PAT,(-) | -12 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 135398737 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | UNDEFINED | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-doxepin | 2 | 91 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1613 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 135398745 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 135398737 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-pirilamine | -4 | 91 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 2286 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 100 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-MEPYRAMINE | -23 | 55 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 11291 | 98340 | 21 | 3H-MEPYRAMINE | -4 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | None | ||
| CHEMBL278398 | 98340 | 21 | 3H-MEPYRAMINE | -4 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 261 | 1 | 0 | 1 | 3.9 | CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12 | None | ||
| 45485473 | 195659 | 0 | UNDEFINED | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 457 | 9 | 1 | 4 | 5.4 | COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL568892 | 195659 | 0 | UNDEFINED | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 457 | 9 | 1 | 4 | 5.4 | COC(=O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 1212 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2995 | 202700 | 49 | 3H-MEPYRAMINE | -14 | 22 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-MEPYRAMINE | -14 | 22 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-MEPYRAMINE | -14 | 22 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1599 | 2309 | 47 | 3H-MEPYRAMINE | -2398 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| 3955 | 2309 | 47 | 3H-MEPYRAMINE | -2398 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| 7215 | 2309 | 47 | 3H-MEPYRAMINE | -2398 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL841 | 2309 | 47 | 3H-MEPYRAMINE | -2398 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| DB00836 | 2309 | 47 | 3H-MEPYRAMINE | -2398 | 15 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | None | ||
| 12057539 | 206301 | 39 | 3H-MEPYRAMINE | -3715 | 20 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | 3H-MEPYRAMINE | -3715 | 20 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | 3H-MEPYRAMINE | -3715 | 20 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 10456093 | 195832 | 0 | UNDEFINED | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 443 | 9 | 2 | 3 | 5.4 | O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL570033 | 195832 | 0 | UNDEFINED | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 443 | 9 | 2 | 3 | 5.4 | O=C(O)c1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 44591134 | 175626 | 0 | UNDEFINED | -169 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| CHEMBL459373 | 175626 | 0 | UNDEFINED | -169 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1212 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 1212 | 1632 | 45 | 3H-doxepin | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-doxepin | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-doxepin | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-doxepin | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-doxepin | -41 | 65 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2337 | 3205 | 72 | UNDEFINED | -1 | 62 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | UNDEFINED | -1 | 62 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | UNDEFINED | -1 | 62 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | UNDEFINED | -1 | 62 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | UNDEFINED | -1 | 62 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 37459 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 62 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| CHEMBL8514 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 16667681 | 214389 | 0 | 3H-trans-H2-PAT,(-) | 4 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1830 | 2552 | 39 | 3H-PYRILAMINE | -125 | 27 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 207 | 2552 | 39 | 3H-PYRILAMINE | -125 | 27 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 23897 | 2552 | 39 | 3H-PYRILAMINE | -125 | 27 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| CHEMBL460 | 2552 | 39 | 3H-PYRILAMINE | -125 | 27 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| DB01618 | 2552 | 39 | 3H-PYRILAMINE | -125 | 27 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 446220 | 132998 | 13 | 3H-PYRILAMINE | -19 | 45 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | ||
| CHEMBL370805 | 132998 | 13 | 3H-PYRILAMINE | -19 | 45 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | ||
| 1615 | 167228 | 22 | 3H-PYRILAMINE | -5 | 44 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | ||
| CHEMBL43048 | 167228 | 22 | 3H-PYRILAMINE | -5 | 44 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | ||
| 1353 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 2284 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 100 | 3745 | 52 | 3H-MEPYRAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-MEPYRAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-MEPYRAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-MEPYRAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-MEPYRAMINE | -7 | 55 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 213 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 2717 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 5533 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| CHEMBL621 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| DB00656 | 3792 | 50 | 3H-PYRILAMINE | -4 | 43 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.7 | pKi | = | 4.7 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | -2 | 91 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 202 | 1480 | 0 | 3H-PYRILAMINE | -1 | 31 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 60835 | 1480 | 0 | 3H-PYRILAMINE | -1 | 31 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 972 | 1480 | 0 | 3H-PYRILAMINE | -1 | 31 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| CHEMBL1175 | 1480 | 0 | 3H-PYRILAMINE | -1 | 31 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| DB00476 | 1480 | 0 | 3H-PYRILAMINE | -1 | 31 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 2181 | 3079 | 0 | 3H-PYRILAMINE | -51 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 4830 | 3079 | 0 | 3H-PYRILAMINE | -51 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 92 | 3079 | 0 | 3H-PYRILAMINE | -51 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| CHEMBL440294 | 3079 | 0 | 3H-PYRILAMINE | -51 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| DB09286 | 3079 | 0 | 3H-PYRILAMINE | -51 | 34 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 16362 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 2172 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 90 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| CHEMBL1423 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| DB01100 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 242 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 34 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 60795 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL1112 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| DB01238 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 2995 | 202700 | 49 | 3H-MEPYRAMINE | -12 | 22 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 2995 | 202700 | 49 | 3H-MEPYRAMINE | -42 | 22 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-MEPYRAMINE | -12 | 22 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-MEPYRAMINE | -42 | 22 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-MEPYRAMINE | -12 | 22 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-MEPYRAMINE | -42 | 22 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 4034 | 214421 | 0 | 3H-MEPYRAMINE | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 390 | 5 | 0 | 2 | 5.6 | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl | None | ||
| CHEMBL1623 | 214421 | 0 | 3H-MEPYRAMINE | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 390 | 5 | 0 | 2 | 5.6 | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl | None | ||
| 1353 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-MEPYRAMINE | -489 | 85 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1242 | 3556 | 23 | 3H-MEPYRAMINE | -147 | 17 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | ||
| 935 | 3556 | 23 | 3H-MEPYRAMINE | -147 | 17 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | ||
| CHEMBL286080 | 3556 | 23 | 3H-MEPYRAMINE | -147 | 17 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | ||
| 9906978 | 42466 | 1 | UNDEFINED | -28 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
| CHEMBL150161 | 42466 | 1 | UNDEFINED | -28 | 12 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 361 | 6 | 1 | 3 | 4.0 | O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 | None | ||
| 2726 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1427 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-MEPYRAMINE | -1 | 26 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| None | 215184 | 0 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 333 | 5 | 1 | 4 | 3.5 | COC1=C(C=CC(=C1)Cl)OC(C2CNCCO2)C3=CC=CC=C3 | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 54477 | 84230 | 34 | UNDEFINED | -70 | 22 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
| CHEMBL22242 | 84230 | 34 | UNDEFINED | -70 | 22 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 370 | 6 | 1 | 4 | 2.7 | CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC | None | ||
| 11848679 | 88814 | 0 | UNDEFINED | -204 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 489 | 9 | 3 | 9 | 2.9 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N | None | ||
| CHEMBL236788 | 88814 | 0 | UNDEFINED | -204 | 6 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 489 | 9 | 3 | 9 | 2.9 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)cc(OCC)c1N | None | ||
| 24740863 | 88728 | 0 | UNDEFINED | -3 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 385 | 6 | 1 | 5 | 5.0 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl | None | ||
| CHEMBL236610 | 88728 | 0 | UNDEFINED | -3 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 385 | 6 | 1 | 5 | 5.0 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl | None | ||
| 1170 | 1603 | 71 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 3348 | 1603 | 71 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 4819 | 1603 | 71 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 74685737 | 1603 | 71 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| CHEMBL914 | 1603 | 71 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| DB00950 | 1603 | 71 | UNDEFINED | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 11954259 | 214201 | 0 | 3H-MEPYRAMINE | -89 | 43 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
| 2470 | 3596 | 46 | 3H-MEPYRAMINE | -81283 | 59 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | 3H-MEPYRAMINE | -81283 | 59 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | 3H-MEPYRAMINE | -81283 | 59 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | 3H-MEPYRAMINE | -81283 | 59 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | 3H-MEPYRAMINE | -81283 | 59 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 4528 | 214218 | 0 | 3H-doxepin | -1 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 238 | 1 | 1 | 2 | 2.8 | CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 2470 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 1223 | 940 | 32 | 3H-MEPYRAMINE | -14125 | 11 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 308 | 6 | 2 | 3 | 3.2 | Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N | None | ||
| 2790 | 940 | 32 | 3H-MEPYRAMINE | -14125 | 11 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 308 | 6 | 2 | 3 | 3.2 | Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N | None | ||
| CHEMBL14690 | 940 | 32 | 3H-MEPYRAMINE | -14125 | 11 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 308 | 6 | 2 | 3 | 3.2 | Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N | None | ||
| None | 214330 | 0 | 3H-PYRILAMINE | 1 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 485 | 10 | 1 | 8 | 3.0 | CC(C1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC=C(C=C4)Cl)O | None | ||
| 2771 | 193347 | 67 | 3H-PYRILAMINE | -9 | 26 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 2771 | 193347 | 67 | 3H-PYRILAMINE | -2 | 26 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | 3H-PYRILAMINE | -9 | 26 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | 3H-PYRILAMINE | -2 | 26 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | 3H-PYRILAMINE | -9 | 26 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | 3H-PYRILAMINE | -2 | 26 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 242 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 34 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 60795 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL1112 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| DB01238 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 213 | 3792 | 50 | 3H-PYRILAMINE | -1 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 2717 | 3792 | 50 | 3H-PYRILAMINE | -1 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 5533 | 3792 | 50 | 3H-PYRILAMINE | -1 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| CHEMBL621 | 3792 | 50 | 3H-PYRILAMINE | -1 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| DB00656 | 3792 | 50 | 3H-PYRILAMINE | -1 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 444 | 214245 | 0 | 3H-PYRILAMINE | -6 | 17 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 239 | 3 | 1 | 2 | 3.3 | CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C | None | ||
| 242 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 34 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 60795 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL1112 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| DB01238 | 467 | 117 | 3H-PYRILAMINE | -23 | 51 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| None | 215423 | 0 | UNDEFINED | -190 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 532 | 10 | 0 | 4 | 8.0 | CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5 | None | ||
| 2402 | 3318 | 58 | 3H-PYRILAMINE | -194 | 25 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| 5095 | 3318 | 58 | 3H-PYRILAMINE | -194 | 25 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| 7295 | 3318 | 58 | 3H-PYRILAMINE | -194 | 25 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| CHEMBL589 | 3318 | 58 | 3H-PYRILAMINE | -194 | 25 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| DB00268 | 3318 | 58 | 3H-PYRILAMINE | -194 | 25 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| 1210 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2726 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | 2 | 91 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 277 | 1274 | 55 | 3H-MEPYRAMINE | -3 | 45 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 2913 | 1274 | 55 | 3H-MEPYRAMINE | -3 | 45 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 765 | 1274 | 55 | 3H-MEPYRAMINE | -3 | 45 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| CHEMBL516 | 1274 | 55 | 3H-MEPYRAMINE | -3 | 45 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| DB00434 | 1274 | 55 | 3H-MEPYRAMINE | -3 | 45 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | ||
| 3103 | 214415 | 0 | 3H-MEPYRAMINE | 1 | 4 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 281 | 4 | 0 | 2 | 3.9 | CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3 | None | ||
| 1222 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2600 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 2608 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 5405 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| CHEMBL17157 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| DB00342 | 3720 | 73 | 3H-MEPYRAMINE | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -3 | 11 | Mouse | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -3 | 11 | Mouse | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -3 | 11 | Mouse | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -3 | 11 | Mouse | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -3 | 11 | Mouse | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -3 | 11 | Mouse | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2286 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | 3H-MEPYRAMINE | -1 | 29 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 55482 | 214386 | 0 | 3H-MEPYRAMINE | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 441 | 8 | 2 | 5 | 4.0 | CC1=NC=C(C=C1)CC2=CN=C(NC2=O)NCCCCC3=NC=C(C=C3C)Br | None | ||
| 3103 | 214415 | 0 | 3H-MEPYRAMINE | -1 | 4 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 281 | 4 | 0 | 2 | 3.9 | CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3 | None | ||
| 103 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 2875 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 5736 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL285802 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB09225 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 135409468 | 2004 | 63 | 3H-PYRILAMINE | -1 | 40 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
| 333 | 2004 | 63 | 3H-PYRILAMINE | -1 | 40 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
| CHEMBL845 | 2004 | 63 | 3H-PYRILAMINE | -1 | 40 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | ||
| 103 | 4089 | 56 | 3H-PYRILAMINE | -2 | 53 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 2875 | 4089 | 56 | 3H-PYRILAMINE | -2 | 53 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 5736 | 4089 | 56 | 3H-PYRILAMINE | -2 | 53 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL285802 | 4089 | 56 | 3H-PYRILAMINE | -2 | 53 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB09225 | 4089 | 56 | 3H-PYRILAMINE | -2 | 53 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 115237 | 55296 | 113 | 3H-PYRILAMINE | -6 | 54 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| CHEMBL1621 | 55296 | 113 | 3H-PYRILAMINE | -6 | 54 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | -2 | 65 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | -2 | 65 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | -2 | 65 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | -2 | 65 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 11976 | 907 | 54 | UNDEFINED | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| 667467 | 907 | 54 | UNDEFINED | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| CHEMBL908 | 907 | 54 | UNDEFINED | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| DB01239 | 907 | 54 | UNDEFINED | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1210 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-doxepin | -12 | 20 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1890 | 2718 | 44 | 3H-PYRILAMINE | -4 | 15 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 4449 | 2718 | 44 | 3H-PYRILAMINE | -4 | 15 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 7247 | 2718 | 44 | 3H-PYRILAMINE | -4 | 15 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| CHEMBL623 | 2718 | 44 | 3H-PYRILAMINE | -4 | 15 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| DB01149 | 2718 | 44 | 3H-PYRILAMINE | -4 | 15 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 2284 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | 3H-MEPYRAMINE | -10 | 28 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4543 | 169982 | 36 | 3H-MEPYRAMINE | -4 | 29 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | 3H-MEPYRAMINE | -4 | 29 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | 3H-MEPYRAMINE | -4 | 29 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 134 | 2478 | 19 | 3H-MEPYRAMINE | -2570 | 67 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 134 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | 3H-MEPYRAMINE | -2570 | 67 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | 3H-MEPYRAMINE | -2570 | 67 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | 3H-MEPYRAMINE | -2570 | 67 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | 3H-MEPYRAMINE | -2570 | 67 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 125564 | 659 | 88 | 3H-PYRILAMINE | -5248 | 7 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 367 | 3 | 0 | 3 | 4.7 | CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F | None | ||
| 388 | 659 | 88 | 3H-PYRILAMINE | -5248 | 7 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 367 | 3 | 0 | 3 | 4.7 | CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F | None | ||
| 7670 | 659 | 88 | 3H-PYRILAMINE | -5248 | 7 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 367 | 3 | 0 | 3 | 4.7 | CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F | None | ||
| CHEMBL178803 | 659 | 88 | 3H-PYRILAMINE | -5248 | 7 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 367 | 3 | 0 | 3 | 4.7 | CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F | None | ||
| DB09223 | 659 | 88 | 3H-PYRILAMINE | -5248 | 7 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 367 | 3 | 0 | 3 | 4.7 | CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F | None | ||
| 1427 | 1982 | 50 | 3H-Histamine | -1 | 26 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-Histamine | -1 | 26 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-Histamine | -1 | 26 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-Histamine | -1 | 26 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-Histamine | -1 | 26 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 2995 | 202700 | 49 | 3H-PYRILAMINE | -12 | 22 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 2995 | 202700 | 49 | 3H-PYRILAMINE | -14 | 22 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-PYRILAMINE | -12 | 22 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-PYRILAMINE | -14 | 22 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-PYRILAMINE | -12 | 22 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-PYRILAMINE | -14 | 22 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 37459 | 735 | 10 | 3H-MEPYRAMINE | -7244 | 24 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 62 | 735 | 10 | 3H-MEPYRAMINE | -7244 | 24 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| CHEMBL8514 | 735 | 10 | 3H-MEPYRAMINE | -7244 | 24 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 40589 | 214376 | 0 | 3H-PYRILAMINE | -5 | 8 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 377 | 7 | 0 | 6 | 2.5 | CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 115237 | 55296 | 113 | 3H-PYRILAMINE | -6 | 54 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| CHEMBL1621 | 55296 | 113 | 3H-PYRILAMINE | -6 | 54 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| 2435 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 60149 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 98 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| CHEMBL12713 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| DB06144 | 3533 | 78 | 3H-PYRILAMINE | -95 | 48 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 1209 | 1628 | 69 | 3H-MEPYRAMINE | -602 | 31 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | 3H-MEPYRAMINE | -602 | 31 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | 3H-MEPYRAMINE | -602 | 31 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | 3H-MEPYRAMINE | -602 | 31 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | 3H-MEPYRAMINE | -602 | 31 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 108107 | 79534 | 30 | 3H-MEPYRAMINE | -5 | 15 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | ||
| 156592250 | 79534 | 30 | 3H-MEPYRAMINE | -5 | 15 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | ||
| CHEMBL1256878 | 79534 | 30 | 3H-MEPYRAMINE | -5 | 15 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | ||
| CHEMBL212579 | 79534 | 30 | 3H-MEPYRAMINE | -5 | 15 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 319 | 3 | 4 | 5 | 0.5 | N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 | None | ||
| 45485498 | 195994 | 0 | UNDEFINED | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 231 | 5 | 0 | 1 | 3.8 | Cc1ccc(CCCCN2CCCCC2)cc1 | None | ||
| CHEMBL571073 | 195994 | 0 | UNDEFINED | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 231 | 5 | 0 | 1 | 3.8 | Cc1ccc(CCCCN2CCCCC2)cc1 | None | ||
| 7153 | 97570 | 74 | 3H-PYRILAMINE | -16 | 33 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | ||
| CHEMBL272942 | 97570 | 74 | 3H-PYRILAMINE | -16 | 33 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 1221 | 472 | 9 | 3H-MEPYRAMINE | 2 | 3 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | None | ||
| 65895 | 472 | 9 | 3H-MEPYRAMINE | 2 | 3 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | None | ||
| CHEMBL293802 | 472 | 9 | 3H-MEPYRAMINE | 2 | 3 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | None | ||
| 1353 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 2142 | 3047 | 54 | 3H-MEPYRAMINE | -1258 | 36 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | 3H-MEPYRAMINE | -1258 | 36 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | 3H-MEPYRAMINE | -1258 | 36 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | 3H-MEPYRAMINE | -1258 | 36 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | 3H-MEPYRAMINE | -1258 | 36 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | 3H-MEPYRAMINE | -1258 | 36 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 134 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 4.5 | pKi | = | 4.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 4.5 | pKi | = | 4.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 4.5 | pKi | = | 4.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 4.5 | pKi | = | 4.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | 3H-MEPYRAMINE | -15488 | 67 | Rat | 4.5 | pKi | = | 4.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 2601 | 3721 | 30 | 3H-PYRILAMINE | -389 | 21 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 443951 | 3721 | 30 | 3H-PYRILAMINE | -389 | 21 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 56 | 3721 | 30 | 3H-PYRILAMINE | -389 | 21 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL73151 | 3721 | 30 | 3H-PYRILAMINE | -389 | 21 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB13399 | 3721 | 30 | 3H-PYRILAMINE | -389 | 21 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 100 | 3745 | 52 | 3H-MEPYRAMINE | -16 | 55 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | 3H-MEPYRAMINE | -16 | 55 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | 3H-MEPYRAMINE | -16 | 55 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | 3H-MEPYRAMINE | -16 | 55 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | 3H-MEPYRAMINE | -16 | 55 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 1588 | 2294 | 24 | 3H-PYRILAMINE | -144 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 28864 | 2294 | 24 | 3H-PYRILAMINE | -144 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 43 | 2294 | 24 | 3H-PYRILAMINE | -144 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL157138 | 2294 | 24 | 3H-PYRILAMINE | -144 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB00589 | 2294 | 24 | 3H-PYRILAMINE | -144 | 43 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 2762 | 3802 | 28 | 3H-MEPYRAMINE | 9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 5587 | 3802 | 28 | 3H-MEPYRAMINE | 9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 7318 | 3802 | 28 | 3H-MEPYRAMINE | 9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| CHEMBL1241 | 3802 | 28 | 3H-MEPYRAMINE | 9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| DB00792 | 3802 | 28 | 3H-MEPYRAMINE | 9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 3 | 2.7 | CN(CCN(c1ccccn1)Cc1ccccc1)C | None | ||
| 4528 | 214218 | 0 | 3H-PYRILAMINE | -7 | 9 | Rat | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 238 | 1 | 1 | 2 | 2.8 | CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3 | None | ||
| 2771 | 193347 | 67 | 3H-MEPYRAMINE | -6 | 26 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | 3H-MEPYRAMINE | -6 | 26 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | 3H-MEPYRAMINE | -6 | 26 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 1221 | 472 | 9 | 3H-MEPYRAMINE | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | None | ||
| 65895 | 472 | 9 | 3H-MEPYRAMINE | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | None | ||
| CHEMBL293802 | 472 | 9 | 3H-MEPYRAMINE | -12 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | None | ||
| 2726 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-MEPYRAMINE | -17 | 72 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 3947 | 214378 | 0 | 3H-PYRILAMINE | -7 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 418 | 7 | 0 | 3 | 5.8 | CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl | None | ||
| 11848625 | 5715 | 0 | UNDEFINED | -38 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 451 | 8 | 1 | 7 | 4.9 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1 | None | ||
| CHEMBL1078745 | 5715 | 0 | UNDEFINED | -38 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 451 | 8 | 1 | 7 | 4.9 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1 | None | ||
| 16667681 | 214389 | 0 | 3H-MEPYRAMINE | 4 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -602 | 85 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1427 | 1982 | 50 | 3H-PYRILAMINE | -5 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 357 | 1982 | 50 | 3H-PYRILAMINE | -5 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 3696 | 1982 | 50 | 3H-PYRILAMINE | -5 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL11 | 1982 | 50 | 3H-PYRILAMINE | -5 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00458 | 1982 | 50 | 3H-PYRILAMINE | -5 | 26 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | None | ||
| 1890 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 1890 | 2718 | 44 | 3H-MEPYRAMINE | -57 | 15 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 4449 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 4449 | 2718 | 44 | 3H-MEPYRAMINE | -57 | 15 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 7247 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 7247 | 2718 | 44 | 3H-MEPYRAMINE | -57 | 15 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| CHEMBL623 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| CHEMBL623 | 2718 | 44 | 3H-MEPYRAMINE | -57 | 15 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| DB01149 | 2718 | 44 | 3H-PYRILAMINE | -44 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| DB01149 | 2718 | 44 | 3H-MEPYRAMINE | -57 | 15 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 1353 | 1880 | 85 | 3H-pirilamine | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-pirilamine | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-pirilamine | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-pirilamine | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-pirilamine | -602 | 85 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 6852400 | 214160 | 0 | UNDEFINED | -977 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
| 73759726 | 214160 | 0 | UNDEFINED | -977 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
| 44622872 | 196039 | 0 | UNDEFINED | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 413 | 8 | 1 | 2 | 6.0 | Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL571389 | 196039 | 0 | UNDEFINED | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 413 | 8 | 1 | 2 | 6.0 | Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 25212275 | 173849 | 0 | UNDEFINED | -9332 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | None | ||
| CHEMBL455288 | 173849 | 0 | UNDEFINED | -9332 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | None | ||
| 6852400 | 214160 | 0 | 3H-doxepin | -977 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
| 73759726 | 214160 | 0 | 3H-doxepin | -977 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | ||
| 3025067 | 98923 | 58 | 3H-MEPYRAMINE | -199 | 14 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | ||
| 65853 | 98923 | 58 | 3H-MEPYRAMINE | -199 | 14 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | ||
| CHEMBL282614 | 98923 | 58 | 3H-MEPYRAMINE | -199 | 14 | Rat | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 220 | 1 | 1 | 4 | 0.9 | c1cc2c(c(N3CCNCC3)c1)OCCO2 | None | ||
| 1613 | 2316 | 44 | 3H-Histamine | -3 | 44 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | 3H-Histamine | -3 | 44 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | 3H-Histamine | -3 | 44 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | 3H-Histamine | -3 | 44 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | 3H-Histamine | -3 | 44 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | -2 | 91 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1227 | 2454 | 35 | 3H-doxepin | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-doxepin | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-doxepin | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-doxepin | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-doxepin | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-doxepin | -2 | 11 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2286 | 3134 | 48 | 3H-PYRILAMINE | -1 | 29 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | 3H-PYRILAMINE | -1 | 29 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | 3H-PYRILAMINE | -1 | 29 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | 3H-PYRILAMINE | -1 | 29 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | 3H-PYRILAMINE | -1 | 29 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 11954259 | 214201 | 0 | 3H-PYRILAMINE | -19 | 43 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
| 20980871 | 214683 | 0 | 3H-MEPYRAMINE | 4 | 7 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 295 | 3 | 0 | 2 | 4.7 | CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31 | None | ||
| 135 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-MEPYRAMINE | 1 | 57 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 180 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2554 | 784 | 115 | None | 1 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 489 | 784 | 115 | None | 1 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 5339 | 784 | 115 | None | 1 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| CHEMBL108 | 784 | 115 | None | 1 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| DB00564 | 784 | 115 | None | 1 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 135 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | 3H-PYRILAMINE | -1 | 57 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 2284 | 3133 | 27 | 3H-MEPYRAMINE | 1 | 28 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | 3H-MEPYRAMINE | 1 | 28 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | 3H-MEPYRAMINE | 1 | 28 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | 3H-MEPYRAMINE | 1 | 28 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | 3H-MEPYRAMINE | 1 | 28 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 2726 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 135398745 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-pirilamine | -1 | 65 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 11954259 | 214201 | 0 | 3H-doxepin | -19 | 43 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
| 2726 | 906 | 64 | 3H-MEPYRAMINE | -6 | 72 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-MEPYRAMINE | -6 | 72 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-MEPYRAMINE | -6 | 72 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-MEPYRAMINE | -6 | 72 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-MEPYRAMINE | -6 | 72 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -5 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -5 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -5 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -5 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -5 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -5 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4098 | 32289 | 24 | 3H-MEPYRAMINE | -1 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | None | ||
| CHEMBL1255739 | 32289 | 24 | 3H-MEPYRAMINE | -1 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | None | ||
| CHEMBL1411979 | 32289 | 24 | 3H-MEPYRAMINE | -1 | 11 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | None | ||
| 2865 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 165193 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 2303 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 4946 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 564 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 62882 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 63 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 66366 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 91536 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| CHEMBL27 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| CHEMBL452861 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| DB00571 | 3138 | 60 | None | -660 | 42 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 1227 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | 3H-MEPYRAMINE | -2 | 11 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 6834 | 214379 | 0 | 3H-MEPYRAMINE | 1 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 318 | 5 | 0 | 2 | 3.9 | CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2 | None | ||
| 3103 | 214415 | 0 | 3H-MEPYRAMINE | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 281 | 4 | 0 | 2 | 3.9 | CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3 | None | ||
| 1210 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-MEPYRAMINE | -12 | 20 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1613 | 2316 | 44 | 3H-doxepin | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | 3H-doxepin | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | 3H-doxepin | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | 3H-doxepin | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | 3H-doxepin | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | 1 | 65 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 2564 | 214414 | 0 | 3H-MEPYRAMINE | -2 | 3 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 290 | 6 | 0 | 3 | 3.4 | CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 | None | ||
| 1212 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | UNDEFINED | -41 | 65 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2600 | 3720 | 73 | UNDEFINED | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 2608 | 3720 | 73 | UNDEFINED | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 5405 | 3720 | 73 | UNDEFINED | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| CHEMBL17157 | 3720 | 73 | UNDEFINED | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| DB00342 | 3720 | 73 | UNDEFINED | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 25212276 | 189473 | 0 | UNDEFINED | -112 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| CHEMBL517244 | 189473 | 0 | UNDEFINED | -112 | 6 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| 2142 | 3047 | 54 | 3H-doxepin | -263 | 36 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | 3H-doxepin | -263 | 36 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | 3H-doxepin | -263 | 36 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | 3H-doxepin | -263 | 36 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | 3H-doxepin | -263 | 36 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | 3H-doxepin | -263 | 36 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -309 | 23 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 2142 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | 3H-MEPYRAMINE | -7585 | 36 | Rat | 4.4 | pKi | = | 4.4 | Binding | PDSP KiDatabase | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 37459 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 62 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| CHEMBL8514 | 735 | 10 | 3H-MEPYRAMINE | -1174 | 24 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | ||
| 135398737 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-MEPYRAMINE | -4 | 91 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3012003 | 214377 | 0 | 3H-PYRILAMINE | -6 | 12 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 311 | 5 | 0 | 3 | 3.8 | CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3 | None | ||
| 2865 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 3294 | 1975 | 106 | 3H-PYRILAMINE | -630 | 44 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 71360 | 1975 | 106 | 3H-PYRILAMINE | -630 | 44 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 87 | 1975 | 106 | 3H-PYRILAMINE | -630 | 44 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| CHEMBL14376 | 1975 | 106 | 3H-PYRILAMINE | -630 | 44 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| DB04946 | 1975 | 106 | 3H-PYRILAMINE | -630 | 44 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1353 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | UNDEFINED | -489 | 85 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 2435 | 3533 | 78 | UNDEFINED | -851 | 48 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 60149 | 3533 | 78 | UNDEFINED | -851 | 48 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 98 | 3533 | 78 | UNDEFINED | -851 | 48 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| CHEMBL12713 | 3533 | 78 | UNDEFINED | -851 | 48 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| DB06144 | 3533 | 78 | UNDEFINED | -851 | 48 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 7153 | 97570 | 74 | 3H-PYRILAMINE | -23 | 33 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | ||
| CHEMBL272942 | 97570 | 74 | 3H-PYRILAMINE | -23 | 33 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | ||
| 2995 | 202700 | 49 | 3H-MEPYRAMINE | -14 | 22 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-MEPYRAMINE | -14 | 22 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-MEPYRAMINE | -14 | 22 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 4543 | 169982 | 36 | 3H-MEPYRAMINE | -6 | 29 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | 3H-MEPYRAMINE | -6 | 29 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | 3H-MEPYRAMINE | -6 | 29 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 2865 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | 3H-PYRILAMINE | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 21722 | 214239 | 0 | 3H-MEPYRAMINE | -5 | 5 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 2 | 4.3 | CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -46 | 23 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 2865 | 4079 | 67 | UNDEFINED | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | UNDEFINED | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | UNDEFINED | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | UNDEFINED | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | UNDEFINED | -61 | 53 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 2470 | 3596 | 46 | UNDEFINED | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | UNDEFINED | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | UNDEFINED | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | UNDEFINED | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | UNDEFINED | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 2470 | 3596 | 46 | 3H-doxepin | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | 3H-doxepin | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | 3H-doxepin | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | 3H-doxepin | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | 3H-doxepin | -4570 | 59 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 1613 | 2316 | 44 | UNDEFINED | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | UNDEFINED | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | UNDEFINED | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | UNDEFINED | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | UNDEFINED | -3 | 44 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 1816 | 2504 | 99 | 3H-PYRILAMINE | -10 | 16 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | 3H-PYRILAMINE | -10 | 16 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | 3H-PYRILAMINE | -10 | 16 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | 3H-PYRILAMINE | -10 | 16 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | 3H-PYRILAMINE | -10 | 16 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 1548955 | 88153 | 17 | None | 1 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 405 | 9 | 0 | 2 | 6.6 | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 | None | ||
| 2800 | 88153 | 17 | None | 1 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 405 | 9 | 0 | 2 | 6.6 | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 | None | ||
| CHEMBL2355051 | 88153 | 17 | None | 1 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 405 | 9 | 0 | 2 | 6.6 | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 | None | ||
| 2389 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | 3H-PYRILAMINE | -44 | 67 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 2865 | 4079 | 67 | 3H-PYRILAMINE | -17 | 53 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | 3H-PYRILAMINE | -17 | 53 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | 3H-PYRILAMINE | -17 | 53 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | 3H-PYRILAMINE | -17 | 53 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | 3H-PYRILAMINE | -17 | 53 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 2142 | 3047 | 54 | None | -263 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 4920903 | 3047 | 54 | None | -263 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 502 | 3047 | 54 | None | -263 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 5775 | 3047 | 54 | None | -263 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| CHEMBL597 | 3047 | 54 | None | -263 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| DB00692 | 3047 | 54 | None | -263 | 36 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 4 | 2 | 4 | 2.8 | Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 | None | ||
| 2812 | 4711 | 96 | None | -28 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| CHEMBL104 | 4711 | 96 | None | -28 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| 40589 | 214376 | 0 | None | -5 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 377 | 7 | 0 | 6 | 2.5 | CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl | None | ||
| 4528 | 214218 | 0 | None | -1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 238 | 1 | 1 | 2 | 2.8 | CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3 | None | ||
| 3114 | 215976 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 339 | 8 | 1 | 3 | 3.4 | CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=N1)C(C)C | None | ||
| 2181 | 3079 | 0 | None | -51 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 4830 | 3079 | 0 | None | -51 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 92 | 3079 | 0 | None | -51 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| CHEMBL440294 | 3079 | 0 | None | -51 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| DB09286 | 3079 | 0 | None | -51 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 135398745 | 2869 | 108 | UNDEFINED | -1 | 65 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | UNDEFINED | -1 | 65 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | UNDEFINED | -1 | 65 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | UNDEFINED | -1 | 65 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -6 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -6 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -6 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -6 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -6 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 657255 | 197406 | 29 | None | -18 | 15 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 337 | 12 | 2 | 3 | 5.6 | CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 | None | ||
| CHEMBL588119 | 197406 | 29 | None | -18 | 15 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 337 | 12 | 2 | 3 | 5.6 | CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 | None | ||
| 115237 | 55296 | 113 | 3H-PYRILAMINE | -6 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| CHEMBL1621 | 55296 | 113 | 3H-PYRILAMINE | -6 | 54 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| 446220 | 132998 | 13 | None | -19 | 45 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | ||
| CHEMBL370805 | 132998 | 13 | None | -19 | 45 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | ||
| 1830 | 2552 | 39 | None | -125 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 207 | 2552 | 39 | None | -125 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 23897 | 2552 | 39 | None | -125 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| CHEMBL460 | 2552 | 39 | None | -125 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| DB01618 | 2552 | 39 | None | -125 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | None | ||
| 5281878 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5281881 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 948 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 968 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL42055 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL54661 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00875 | 1630 | 33 | 3H-MEPYRAMINE | -1 | 16 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 103 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 2875 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 5736 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL285802 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB09225 | 4089 | 56 | 3H-PYRILAMINE | -1 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 4066 | 202920 | 72 | 3H-doxepin | -1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 322 | 2 | 0 | 3 | 4.6 | c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 | None | ||
| CHEMBL73451 | 202920 | 72 | 3H-doxepin | -1 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 322 | 2 | 0 | 3 | 4.6 | c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 | None | ||
| 1621 | 2396 | 16 | None | -301 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 17 | 2396 | 16 | None | -301 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 5761 | 2396 | 16 | None | -301 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL263881 | 2396 | 16 | None | -301 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB04829 | 2396 | 16 | None | -301 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 11954259 | 214201 | 0 | UNDEFINED | -19 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
| 107782 | 14330 | 16 | None | 1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | None | ||
| 67151996 | 14330 | 16 | None | 1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | None | ||
| CHEMBL1201207 | 14330 | 16 | None | 1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 472 | 4 | 4 | 6 | 2.0 | C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O | None | ||
| 5048 | 3084 | 57 | None | -109 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | None | ||
| 8924 | 3084 | 57 | None | -109 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | None | ||
| 9948102 | 3084 | 57 | None | -109 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | None | ||
| CHEMBL462605 | 3084 | 57 | None | -109 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | None | ||
| DB11642 | 3084 | 57 | None | -109 | 7 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | None | ||
| 1209 | 1628 | 69 | None | -144 | 31 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | None | -144 | 31 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | None | -144 | 31 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | None | -144 | 31 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | None | -144 | 31 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 2181 | 3079 | 0 | 3H-PYRILAMINE | -794 | 34 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 4830 | 3079 | 0 | 3H-PYRILAMINE | -794 | 34 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 92 | 3079 | 0 | 3H-PYRILAMINE | -794 | 34 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| CHEMBL440294 | 3079 | 0 | 3H-PYRILAMINE | -794 | 34 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| DB09286 | 3079 | 0 | 3H-PYRILAMINE | -794 | 34 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | ||
| 46882182 | 5844 | 0 | UNDEFINED | -95 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 567 | 11 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1 | None | ||
| CHEMBL1079686 | 5844 | 0 | UNDEFINED | -95 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 567 | 11 | 1 | 9 | 4.7 | CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)N(C)C)ccc4o3)CC2)cc(OCC)c1-n1cccc1 | None | ||
| 53389 | 97995 | 15 | 3H-MEPYRAMINE | 1 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 3.9 | C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1 | None | ||
| CHEMBL275707 | 97995 | 15 | 3H-MEPYRAMINE | 1 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 3.9 | C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1 | None | ||
| 68617 | 203816 | 60 | 3H-PYRILAMINE | -1023 | 25 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL1709 | 203816 | 60 | 3H-PYRILAMINE | -1023 | 25 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL809 | 203816 | 60 | 3H-PYRILAMINE | -1023 | 25 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| None | 214366 | 0 | 3H-KETANSERIN | -5011 | 23 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 772 | 16 | 4 | 10 | 5.5 | CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O | None | ||
| 191 | 399 | 92 | 3H-Histamine | -56 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| 201 | 399 | 92 | 3H-Histamine | -56 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| 2170 | 399 | 92 | 3H-Histamine | -56 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| CHEMBL1113 | 399 | 92 | 3H-Histamine | -56 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| DB00543 | 399 | 92 | 3H-Histamine | -56 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| 1353 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-MEPYRAMINE | -602 | 85 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 68617 | 203816 | 60 | 3H-PYRILAMINE | -831 | 25 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL1709 | 203816 | 60 | 3H-PYRILAMINE | -831 | 25 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL809 | 203816 | 60 | 3H-PYRILAMINE | -831 | 25 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| 2865 | 4079 | 67 | UNDEFINED | -1047 | 53 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | UNDEFINED | -1047 | 53 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | UNDEFINED | -1047 | 53 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | UNDEFINED | -1047 | 53 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | UNDEFINED | -1047 | 53 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 5568 | 195823 | 26 | 3H-MEPYRAMINE | -25 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 352 | 4 | 0 | 3 | 5.3 | CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 | None | ||
| 66069 | 195823 | 26 | 3H-MEPYRAMINE | -25 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 352 | 4 | 0 | 3 | 5.3 | CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 | None | ||
| CHEMBL1201102 | 195823 | 26 | 3H-MEPYRAMINE | -25 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 352 | 4 | 0 | 3 | 5.3 | CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 | None | ||
| CHEMBL570 | 195823 | 26 | 3H-MEPYRAMINE | -25 | 5 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 352 | 4 | 0 | 3 | 5.3 | CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 | None | ||
| 11848677 | 147820 | 0 | UNDEFINED | -1 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 460 | 8 | 2 | 8 | 3.0 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC | None | ||
| CHEMBL393718 | 147820 | 0 | UNDEFINED | -1 | 5 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 460 | 8 | 2 | 8 | 3.0 | CCOc1cc(CN2CCC(Nc3nc4cc(S(N)(=O)=O)ccc4o3)CC2)ccc1OC | None | ||
| 1222 | 1634 | 44 | 3H-PYRILAMINE | -891 | 32 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3396 | 1634 | 44 | 3H-PYRILAMINE | -891 | 32 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 85 | 1634 | 44 | 3H-PYRILAMINE | -891 | 32 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL46516 | 1634 | 44 | 3H-PYRILAMINE | -891 | 32 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| DB04842 | 1634 | 44 | 3H-PYRILAMINE | -891 | 32 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 1209 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | 3H-PYRILAMINE | -144 | 31 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 54841 | 201437 | 51 | 3H-PYRILAMINE | -2 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| CHEMBL641 | 201437 | 51 | 3H-PYRILAMINE | -2 | 28 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| 44591012 | 175007 | 0 | UNDEFINED | -114 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 522 | 10 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| CHEMBL457957 | 175007 | 0 | UNDEFINED | -114 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 522 | 10 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| 1192 | 147 | 41 | 3H-MEPYRAMINE | -91 | 16 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | None | ||
| 1794 | 147 | 41 | 3H-MEPYRAMINE | -91 | 16 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | None | ||
| CHEMBL501701 | 147 | 41 | 3H-MEPYRAMINE | -91 | 16 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 311 | 2 | 3 | 5 | 0.5 | NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N | None | ||
| 2435 | 3533 | 78 | 3H-PYRILAMINE | -1122 | 48 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 60149 | 3533 | 78 | 3H-PYRILAMINE | -1122 | 48 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 98 | 3533 | 78 | 3H-PYRILAMINE | -1122 | 48 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| CHEMBL12713 | 3533 | 78 | 3H-PYRILAMINE | -1122 | 48 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| DB06144 | 3533 | 78 | 3H-PYRILAMINE | -1122 | 48 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 12057539 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | 3H-MEPYRAMINE | -676 | 20 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 15387 | 214209 | 0 | 3H-PYRILAMINE | -8 | 23 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
| 33630 | 178379 | 94 | None | -13 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
| CHEMBL47050 | 178379 | 94 | None | -13 | 27 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
| 2726 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-PYRILAMINE | -2 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 135398737 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | 3H-PYRILAMINE | -4 | 91 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 11954259 | 214201 | 0 | 3H-doxepin | -19 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | ||
| None | 214385 | 0 | 3H-MEPYRAMINE | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 411 | 6 | 0 | 1 | 0.8 | CC1=CC=C(C=C1)C(C2=CC=CC=C2)OCC[N+](C)(C)C.[I-] | None | ||
| 6834 | 214379 | 0 | 3H-PYRILAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 318 | 5 | 0 | 2 | 3.9 | CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2 | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 2448 | 214184 | 0 | None | -4 | 17 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 419 | 6 | 1 | 3 | 4.5 | C1CN(CCC1(C2=CC=C(C=C2)Br)O)CCCC(=O)C3=CC=C(C=C3)F | None | ||
| 15723 | 18353 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 267 | 3 | 2 | 2 | 2.9 | OC(c1ccccc1)(c1ccccc1)C1CCNCC1 | None | ||
| CHEMBL127508 | 18353 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 267 | 3 | 2 | 2 | 2.9 | OC(c1ccccc1)(c1ccccc1)C1CCNCC1 | None | ||
| 213 | 3792 | 50 | None | -4 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 2717 | 3792 | 50 | None | -4 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 5533 | 3792 | 50 | None | -4 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| CHEMBL621 | 3792 | 50 | None | -4 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| DB00656 | 3792 | 50 | None | -4 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | ||
| 4020 | 214244 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 1 | 1 | 3 | 2.6 | C1CN2C(=N1)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O | None | ||
| 15387 | 214209 | 0 | None | -8 | 23 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 263 | 5 | 0 | 2 | 3.5 | CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F | None | ||
| 3168 | 9172 | 84 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
| CHEMBL1108 | 9172 | 84 | None | -87 | 21 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
| 1222 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 4543 | 169982 | 36 | 3H-PYRILAMINE | -1 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | 3H-PYRILAMINE | -1 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | 3H-PYRILAMINE | -1 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 1222 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | 3H-MEPYRAMINE | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 133 | 2460 | 48 | None | -102 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| 1723 | 2460 | 48 | None | -102 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| 28693 | 2460 | 48 | None | -102 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| CHEMBL19215 | 2460 | 48 | None | -102 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| DB13520 | 2460 | 48 | None | -102 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| 2470 | 3596 | 46 | None | -4570 | 59 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | None | -4570 | 59 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | None | -4570 | 59 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | None | -4570 | 59 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | None | -4570 | 59 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1353 | 1880 | 85 | None | -213 | 85 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | None | -213 | 85 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | None | -213 | 85 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | None | -213 | 85 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | None | -213 | 85 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| None | 214420 | 0 | 3H-MEPYRAMINE | 1 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 3 | 0 | 2 | 3.7 | CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl | None | ||
| 1353 | 1880 | 85 | None | -602 | 85 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | None | -602 | 85 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | None | -602 | 85 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | None | -602 | 85 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | None | -602 | 85 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1890 | 2718 | 44 | None | -44 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 4449 | 2718 | 44 | None | -44 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 7247 | 2718 | 44 | None | -44 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| CHEMBL623 | 2718 | 44 | None | -44 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| DB01149 | 2718 | 44 | None | -44 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | None | ||
| 3947 | 214378 | 0 | None | -7 | 15 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 418 | 7 | 0 | 3 | 5.8 | CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl | None | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 2771 | 193347 | 67 | None | -2 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | None | -2 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | None | -2 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 2712 | 903 | 33 | None | -5 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | None | ||
| 3370 | 903 | 33 | None | -5 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | None | ||
| 594 | 903 | 33 | None | -5 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | None | ||
| CHEMBL451 | 903 | 33 | None | -5 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | None | ||
| DB00475 | 903 | 33 | None | -5 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 1 | 1 | 3 | 3.0 | CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl | None | ||
| 2564 | 214414 | 0 | 3H-MEPYRAMINE | -2 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 290 | 6 | 0 | 3 | 3.4 | CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 | None | ||
| None | 214420 | 0 | 3H-MEPYRAMINE | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 3 | 0 | 2 | 3.7 | CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl | None | ||
| 16362 | 3076 | 67 | None | -489 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 2172 | 3076 | 67 | None | -489 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 90 | 3076 | 67 | None | -489 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| CHEMBL1423 | 3076 | 67 | None | -489 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| DB01100 | 3076 | 67 | None | -489 | 29 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 4806 | 3945 | 85 | None | -5 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | ||
| 7351 | 3945 | 85 | None | -5 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | ||
| 9966051 | 3945 | 85 | None | -5 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | ||
| CHEMBL2104993 | 3945 | 85 | None | -5 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | ||
| DB09068 | 3945 | 85 | None | -5 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 298 | 3 | 1 | 3 | 3.9 | Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1 | None | ||
| 3151 | 1434 | 93 | None | -41 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | ||
| 945 | 1434 | 93 | None | -41 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | ||
| 965 | 1434 | 93 | None | -41 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | ||
| CHEMBL219916 | 1434 | 93 | None | -41 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | ||
| DB01184 | 1434 | 93 | None | -41 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 425 | 5 | 2 | 5 | 3.4 | Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 | None | ||
| 21722 | 214239 | 0 | None | 1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 4 | 0 | 2 | 4.3 | CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31 | None | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | None | ||
| 4976 | 201885 | 27 | 3H-MEPYRAMINE | -9 | 11 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 263 | 4 | 1 | 1 | 4.3 | CNCCCC1c2ccccc2C=Cc2ccccc21 | None | ||
| CHEMBL668 | 201885 | 27 | 3H-MEPYRAMINE | -9 | 11 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 263 | 4 | 1 | 1 | 4.3 | CNCCCC1c2ccccc2C=Cc2ccccc21 | None | ||
| 2995 | 202700 | 49 | 3H-PYRILAMINE | -14 | 22 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-PYRILAMINE | -14 | 22 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-PYRILAMINE | -14 | 22 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 4020 | 214244 | 0 | 3H-MEPYRAMINE | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 284 | 1 | 1 | 3 | 2.6 | C1CN2C(=N1)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O | None | ||
| 165193 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 2303 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 4946 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 564 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 62882 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 63 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 66366 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 91536 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| CHEMBL27 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| CHEMBL452861 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| DB00571 | 3138 | 60 | 3H-MEPYRAMINE | -660 | 42 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 259 | 6 | 2 | 3 | 2.6 | OC(COc1cccc2c1cccc2)CNC(C)C | None | ||
| 45485462 | 196009 | 0 | UNDEFINED | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 419 | 8 | 1 | 2 | 6.6 | CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1 | None | ||
| CHEMBL571174 | 196009 | 0 | UNDEFINED | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 419 | 8 | 1 | 2 | 6.6 | CC1CCC(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)CC1 | None | ||
| 2200 | 20003 | 57 | 3H-MEPYRAMINE | -26 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | None | ||
| CHEMBL1256819 | 20003 | 57 | 3H-MEPYRAMINE | -26 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | None | ||
| CHEMBL1305 | 20003 | 57 | 3H-MEPYRAMINE | -26 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 265 | 5 | 1 | 3 | 2.7 | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 | None | ||
| 1224 | 1404 | 79 | 3H-doxepin | -2 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-doxepin | -2 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-doxepin | -2 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-doxepin | -2 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-doxepin | -2 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-doxepin | -2 | 13 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 214 | 3799 | 52 | 3H-doxepin | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2740 | 3799 | 52 | 3H-doxepin | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5566 | 3799 | 52 | 3H-doxepin | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 66064 | 3799 | 52 | 3H-doxepin | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL422 | 3799 | 52 | 3H-doxepin | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00831 | 3799 | 52 | 3H-doxepin | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 214 | 3799 | 52 | UNDEFINED | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2740 | 3799 | 52 | UNDEFINED | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5566 | 3799 | 52 | UNDEFINED | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 66064 | 3799 | 52 | UNDEFINED | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL422 | 3799 | 52 | UNDEFINED | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00831 | 3799 | 52 | UNDEFINED | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 11848624 | 88716 | 0 | UNDEFINED | -15 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 381 | 7 | 1 | 6 | 4.3 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC | None | ||
| CHEMBL236587 | 88716 | 0 | UNDEFINED | -15 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 381 | 7 | 1 | 6 | 4.3 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC | None | ||
| 214 | 3799 | 52 | 3H-PYRILAMINE | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2740 | 3799 | 52 | 3H-PYRILAMINE | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5566 | 3799 | 52 | 3H-PYRILAMINE | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 66064 | 3799 | 52 | 3H-PYRILAMINE | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL422 | 3799 | 52 | 3H-PYRILAMINE | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00831 | 3799 | 52 | 3H-PYRILAMINE | -43 | 29 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.2 | pKi | = | 4.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.2 | pKi | = | 4.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.2 | pKi | = | 4.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.2 | pKi | = | 4.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.2 | pKi | = | 4.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 4.2 | pKi | = | 4.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 13091273 | 181856 | 0 | UNDEFINED | -275 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
| CHEMBL478617 | 181856 | 0 | UNDEFINED | -275 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
| CHEMBL553327 | 181856 | 0 | UNDEFINED | -275 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 367 | 6 | 1 | 3 | 4.3 | O=C(CCCN1C2CCC1CC(O)(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
| 45485529 | 196041 | 0 | UNDEFINED | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 385 | 6 | 1 | 2 | 5.2 | Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL571391 | 196041 | 0 | UNDEFINED | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 385 | 6 | 1 | 2 | 5.2 | Cc1ccc(CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 54841 | 201437 | 51 | 3H-Histamine | -6 | 28 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| CHEMBL641 | 201437 | 51 | 3H-Histamine | -6 | 28 | Rat | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| 68617 | 203816 | 60 | 3H-PYRILAMINE | -831 | 25 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL1709 | 203816 | 60 | 3H-PYRILAMINE | -831 | 25 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| CHEMBL809 | 203816 | 60 | 3H-PYRILAMINE | -831 | 25 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 305 | 2 | 1 | 1 | 5.2 | CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 | None | ||
| 15723 | 18353 | 106 | UNDEFINED | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 267 | 3 | 2 | 2 | 2.9 | OC(c1ccccc1)(c1ccccc1)C1CCNCC1 | None | ||
| CHEMBL127508 | 18353 | 106 | UNDEFINED | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 267 | 3 | 2 | 2 | 2.9 | OC(c1ccccc1)(c1ccccc1)C1CCNCC1 | None | ||
| 185 | 3943 | 54 | 3H-PYRILAMINE | -794 | 37 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
| 5311271 | 3943 | 54 | 3H-PYRILAMINE | -794 | 37 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
| CHEMBL74355 | 3943 | 54 | 3H-PYRILAMINE | -794 | 37 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
| DB16351 | 3943 | 54 | 3H-PYRILAMINE | -794 | 37 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | ||
| 2470 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | 3H-MEPYRAMINE | -4570 | 59 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 1212 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 1212 | 1632 | 45 | 3H-MEPYRAMINE | -134 | 65 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-MEPYRAMINE | -134 | 65 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-MEPYRAMINE | -134 | 65 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-MEPYRAMINE | -134 | 65 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-MEPYRAMINE | -134 | 65 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2470 | 3596 | 46 | 3H-MEPYRAMINE | -20417 | 59 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3300 | 3596 | 46 | 3H-MEPYRAMINE | -20417 | 59 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 5265 | 3596 | 46 | 3H-MEPYRAMINE | -20417 | 59 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 99 | 3596 | 46 | 3H-MEPYRAMINE | -20417 | 59 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL267930 | 3596 | 46 | 3H-MEPYRAMINE | -20417 | 59 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 21722 | 214239 | 0 | 3H-MEPYRAMINE | 1 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 284 | 4 | 0 | 2 | 4.3 | CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31 | None | ||
| 44591098 | 176188 | 0 | UNDEFINED | -199 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 508 | 9 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 | None | ||
| CHEMBL460402 | 176188 | 0 | UNDEFINED | -199 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 508 | 9 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 | None | ||
| 16362 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 2172 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 90 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| CHEMBL1423 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| DB01100 | 3076 | 67 | 3H-PYRILAMINE | -489 | 29 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | None | ||
| 242 | 467 | 117 | None | -23 | 51 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 34 | 467 | 117 | None | -23 | 51 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 60795 | 467 | 117 | None | -23 | 51 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 1613 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | 3H-PYRILAMINE | -3 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 135398745 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 135398745 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | UNDEFINED | 1 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | 3H-PYRILAMINE | -1 | 65 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 22530 | 55838 | 54 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 2 | 0 | 2 | 3.7 | CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1 | None | ||
| CHEMBL1600878 | 55838 | 54 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 2 | 0 | 2 | 3.7 | CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1 | None | ||
| CHEMBL1625607 | 55838 | 54 | None | -1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 276 | 2 | 0 | 2 | 3.7 | CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1 | None | ||
| 2995 | 202700 | 49 | None | -14 | 22 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | None | -14 | 22 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | None | -14 | 22 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 11579 | 628 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | None | ||
| 185460 | 628 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | None | ||
| CHEMBL1742423 | 628 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | None | ||
| DB11591 | 628 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | None | ||
| 214 | 3799 | 52 | None | -43 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2740 | 3799 | 52 | None | -43 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5566 | 3799 | 52 | None | -43 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 66064 | 3799 | 52 | None | -43 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL422 | 3799 | 52 | None | -43 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00831 | 3799 | 52 | None | -43 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 49831411 | 216027 | 0 | None | -1 | 14 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 659 | 19 | 0 | 6 | 8.7 | CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12 | None | ||
| 4976 | 201885 | 27 | None | -1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 263 | 4 | 1 | 1 | 4.3 | CNCCCC1c2ccccc2C=Cc2ccccc21 | None | ||
| CHEMBL668 | 201885 | 27 | None | -1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 263 | 4 | 1 | 1 | 4.3 | CNCCCC1c2ccccc2C=Cc2ccccc21 | None | ||
| 146159772 | 2281 | 29 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | ||
| 1564 | 2281 | 29 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | ||
| 1586 | 2281 | 29 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | ||
| 54385 | 2281 | 29 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | ||
| CHEMBL1615438 | 2281 | 29 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | ||
| DB01106 | 2281 | 29 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | ||
| 2726 | 906 | 64 | None | -6 | 72 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | None | -6 | 72 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | None | -6 | 72 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | None | -6 | 72 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | None | -6 | 72 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1212 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-PYRILAMINE | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 2337 | 3205 | 72 | None | -1 | 62 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | None | -1 | 62 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | None | -1 | 62 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | None | -1 | 62 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | None | -1 | 62 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5440 | 216001 | 0 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 399 | 6 | 0 | 5 | 5.0 | CCSC1=CC=C2SC3=CC=CC=C3N(CCCN3CCN(C)CC3)C2=C1 | None | ||
| 11154555 | 788 | 57 | None | -56 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 5037 | 788 | 57 | None | -56 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 7671 | 788 | 57 | None | -56 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL2028019 | 788 | 57 | None | -56 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| CHEMBL3085826 | 788 | 57 | None | -56 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| DB06016 | 788 | 57 | None | -56 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | ||
| 2389 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | None | -50 | 67 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 3389 | 215982 | 0 | None | -1 | 26 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 549 | 12 | 0 | 6 | 6.8 | CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 | None | ||
| 100 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 2637 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 5452 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| CHEMBL479 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| DB00679 | 3745 | 52 | None | -7 | 55 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | ||
| 1385580 | 29063 | 73 | None | -1 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | None | ||
| 4615 | 29063 | 73 | None | -1 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | None | ||
| CHEMBL13828 | 29063 | 73 | None | -1 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | None | ||
| 1588 | 2294 | 24 | None | -51 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 28864 | 2294 | 24 | None | -51 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 43 | 2294 | 24 | None | -51 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL157138 | 2294 | 24 | None | -51 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB00589 | 2294 | 24 | None | -51 | 43 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 11978813 | 713 | 72 | None | -9 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
| 5014 | 713 | 72 | None | -9 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
| 7672 | 713 | 72 | None | -9 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
| CHEMBL2105760 | 713 | 72 | None | -9 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
| DB09128 | 713 | 72 | None | -9 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | None | ||
| 2274 | 3124 | 53 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4917 | 3124 | 53 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 7279 | 3124 | 53 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL728 | 3124 | 53 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00433 | 3124 | 53 | None | -3 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 12488 | 1627 | 51 | None | -2 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | None | ||
| 941361 | 1627 | 51 | None | -2 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | None | ||
| CHEMBL30008 | 1627 | 51 | None | -2 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | None | ||
| DB04841 | 1627 | 51 | None | -2 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 404 | 6 | 0 | 2 | 5.4 | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | None | ||
| 1212 | 1632 | 45 | None | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | None | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | None | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | None | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | None | -41 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 25271818 | 12858 | 52 | None | -1 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| 5281071 | 12858 | 52 | None | -1 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| CHEMBL1189432 | 12858 | 52 | None | -1 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| CHEMBL1719 | 12858 | 52 | None | -1 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| 2865 | 4079 | 67 | None | -17 | 53 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 59 | 4079 | 67 | None | -17 | 53 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 60854 | 4079 | 67 | None | -17 | 53 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| CHEMBL708 | 4079 | 67 | None | -17 | 53 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| DB00246 | 4079 | 67 | None | -17 | 53 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 1222 | 1634 | 44 | None | -17 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 3396 | 1634 | 44 | None | -17 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 85 | 1634 | 44 | None | -17 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| CHEMBL46516 | 1634 | 44 | None | -17 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| DB04842 | 1634 | 44 | None | -17 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 3294 | 1975 | 106 | None | -14 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 71360 | 1975 | 106 | None | -14 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 87 | 1975 | 106 | None | -14 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| CHEMBL14376 | 1975 | 106 | None | -14 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| DB04946 | 1975 | 106 | None | -14 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
| 1214 | 2037 | 51 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1549000 | 2037 | 51 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 1566 | 2037 | 51 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 28145931 | 2037 | 51 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL1201191 | 2037 | 51 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB06282 | 2037 | 51 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 191 | 399 | 92 | None | -56 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| 201 | 399 | 92 | None | -56 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| 2170 | 399 | 92 | None | -56 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| CHEMBL1113 | 399 | 92 | None | -56 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| DB00543 | 399 | 92 | None | -56 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | None | ||
| 4601 | 205020 | 29 | None | -1 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | None | ||
| CHEMBL1201023 | 205020 | 29 | None | -1 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | None | ||
| CHEMBL900 | 205020 | 29 | None | -1 | 17 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 269 | 6 | 0 | 2 | 3.7 | Cc1ccccc1C(OCCN(C)C)c1ccccc1 | None | ||
| 1212 | 1632 | 45 | 3H-MEPYRAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 204 | 1632 | 45 | 3H-MEPYRAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 3372 | 1632 | 45 | 3H-MEPYRAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL726 | 1632 | 45 | 3H-MEPYRAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00623 | 1632 | 45 | 3H-MEPYRAMINE | -41 | 65 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 16667681 | 214389 | 0 | 3H-MEPYRAMINE | -33 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1204 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-MEPYRAMINE | -501 | 23 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1353 | 1880 | 85 | UNDEFINED | -602 | 85 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | UNDEFINED | -602 | 85 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | UNDEFINED | -602 | 85 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | UNDEFINED | -602 | 85 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | UNDEFINED | -602 | 85 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 73333 | 5886 | 23 | UNDEFINED | -10 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 401 | 7 | 1 | 2 | 4.2 | CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
| CHEMBL1079935 | 5886 | 23 | UNDEFINED | -10 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 401 | 7 | 1 | 2 | 4.2 | CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | ||
| 2771 | 193347 | 67 | 3H-PYRILAMINE | -6 | 26 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1200781 | 193347 | 67 | 3H-PYRILAMINE | -6 | 26 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL549 | 193347 | 67 | 3H-PYRILAMINE | -6 | 26 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| None | 214360 | 0 | 3H-PYRILAMINE | -2041 | 7 | Bovine | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 401 | 5 | 1 | 5 | 2.2 | C1COC(C2=CC=CC=C21)CCN3CCN(CC3)C4=CC=C(C=C4)S(=O)(=O)N | None | ||
| 44591099 | 175616 | 0 | UNDEFINED | -295 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| CHEMBL459350 | 175616 | 0 | UNDEFINED | -295 | 6 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | ||
| 1353 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-PYRILAMINE | -489 | 85 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | None | ||
| 3191 | 102385 | 93 | None | 2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| CHEMBL305660 | 102385 | 93 | None | 2 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 469 | 9 | 0 | 3 | 7.2 | CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 | None | ||
| 4066 | 202920 | 72 | None | -1 | 7 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 322 | 2 | 0 | 3 | 4.6 | c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 | None | ||
| CHEMBL73451 | 202920 | 72 | None | -1 | 7 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 322 | 2 | 0 | 3 | 4.6 | c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 | None | ||
| 1210 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | 3H-MEPYRAMINE | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 209 | 3008 | 94 | 3H-PYRILAMINE | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 209 | 3008 | 94 | 3H-doxepin | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 2113 | 3008 | 94 | 3H-PYRILAMINE | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 2113 | 3008 | 94 | 3H-doxepin | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4748 | 3008 | 94 | 3H-PYRILAMINE | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4748 | 3008 | 94 | 3H-doxepin | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL567 | 3008 | 94 | 3H-PYRILAMINE | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL567 | 3008 | 94 | 3H-doxepin | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00850 | 3008 | 94 | 3H-PYRILAMINE | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00850 | 3008 | 94 | 3H-doxepin | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| None | 214417 | 0 | 3H-MEPYRAMINE | 1258 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 408 | 7 | 2 | 4 | 3.9 | CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O | None | ||
| 2801 | 161325 | 56 | None | -1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | None | ||
| CHEMBL1200710 | 161325 | 56 | None | -1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | None | ||
| CHEMBL415 | 161325 | 56 | None | -1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 314 | 4 | 0 | 2 | 4.5 | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 | None | ||
| 1547484 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 654 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 9072 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL43064 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| DB00568 | 927 | 70 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 368 | 6 | 0 | 2 | 5.1 | c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 3103 | 214415 | 0 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 281 | 4 | 0 | 2 | 3.9 | CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3 | None | ||
| 11140 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | None | ||
| 1784 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | None | ||
| 26388 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | None | ||
| CHEMBL398615 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | None | ||
| DB13591 | 2483 | 43 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 445 | 6 | 1 | 6 | 3.3 | NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C | None | ||
| 209 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 2113 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4748 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL567 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00850 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 2267 | 553 | 64 | None | 10 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | None | ||
| 271 | 553 | 64 | None | 10 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | None | ||
| 7121 | 553 | 64 | None | 10 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | None | ||
| CHEMBL639 | 553 | 64 | None | 10 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | None | ||
| DB00972 | 553 | 64 | None | 10 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | None | ||
| 2726 | 906 | 64 | None | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | None | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | None | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | None | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | None | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1613 | 2316 | 44 | None | -3 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 205 | 2316 | 44 | None | -3 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 3964 | 2316 | 44 | None | -3 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| CHEMBL831 | 2316 | 44 | None | -3 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| DB00408 | 2316 | 44 | None | -3 | 44 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | ||
| 135398745 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | None | -2 | 65 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 6834 | 214379 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 318 | 5 | 0 | 2 | 3.9 | CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2 | None | ||
| 4066 | 202920 | 72 | None | -1 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 322 | 2 | 0 | 3 | 4.6 | c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 | None | ||
| CHEMBL73451 | 202920 | 72 | None | -1 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 322 | 2 | 0 | 3 | 4.6 | c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 | None | ||
| 115237 | 55296 | 113 | None | -6 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| CHEMBL1621 | 55296 | 113 | None | -6 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | ||
| 25271818 | 12858 | 52 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| 5281071 | 12858 | 52 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| CHEMBL1189432 | 12858 | 52 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| CHEMBL1719 | 12858 | 52 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 337 | 5 | 1 | 3 | 3.6 | CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21 | None | ||
| 180 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | 3H-MEPYRAMINE | -11 | 38 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 209 | 3008 | 94 | UNDEFINED | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 2113 | 3008 | 94 | UNDEFINED | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4748 | 3008 | 94 | UNDEFINED | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL567 | 3008 | 94 | UNDEFINED | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00850 | 3008 | 94 | UNDEFINED | -11 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 6726 | 1254 | 46 | None | 3 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 7151 | 1254 | 46 | None | 3 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 749 | 1254 | 46 | None | 3 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL648 | 1254 | 46 | None | 3 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| DB01176 | 1254 | 46 | None | 3 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 212 | 3746 | 43 | None | -5 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
| 2639 | 3746 | 43 | None | -5 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
| 941651 | 3746 | 43 | None | -5 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
| CHEMBL1201 | 3746 | 43 | None | -5 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
| DB01623 | 3746 | 43 | None | -5 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | ||
| 4543 | 169982 | 36 | 3H-doxepin | -1 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1201156 | 169982 | 36 | 3H-doxepin | -1 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL445 | 169982 | 36 | 3H-doxepin | -1 | 29 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 263 | 3 | 1 | 1 | 3.8 | CNCCC=C1c2ccccc2CCc2ccccc21 | None | ||
| 19861 | 205790 | 45 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 290 | 0 | 0 | 2 | 3.7 | CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | None | ||
| CHEMBL946 | 205790 | 45 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 290 | 0 | 0 | 2 | 3.7 | CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 | None | ||
| 135398737 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | None | -2 | 91 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 11976 | 907 | 54 | None | -4 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| 667467 | 907 | 54 | None | -4 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| CHEMBL908 | 907 | 54 | None | -4 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| DB01239 | 907 | 54 | None | -4 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | ||
| 6075 | 149575 | 36 | None | 2 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 310 | 2 | 0 | 3 | 4.6 | CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 | None | ||
| CHEMBL395110 | 149575 | 36 | None | 2 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 310 | 2 | 0 | 3 | 4.6 | CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 | None | ||
| 135398737 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | None | -4 | 91 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 26987 | 936 | 29 | None | 16 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| 6063 | 936 | 29 | None | 16 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| 671 | 936 | 29 | None | 16 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| CHEMBL1626 | 936 | 29 | None | 16 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| DB00283 | 936 | 29 | None | 16 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| 1210 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | None | -7 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1400 | 1926 | 64 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 3658 | 1926 | 64 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 7199 | 1926 | 64 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 91513 | 1926 | 64 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| CHEMBL896 | 1926 | 64 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| DB00557 | 1926 | 64 | None | 2 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | None | ||
| 2284 | 3133 | 27 | None | 1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 4926 | 3133 | 27 | None | 1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 7281 | 3133 | 27 | None | 1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| CHEMBL564 | 3133 | 27 | None | 1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| DB00420 | 3133 | 27 | None | 1 | 28 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | None | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | None | ||
| 5284550 | 215977 | 0 | None | -1 | 9 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 3 | 0 | 2 | 4.7 | CN(C)CC\C=C1/C2=CC=CC=C2CSC2=CC=CC=C12 | None | ||
| 2337 | 3205 | 72 | UNDEFINED | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | UNDEFINED | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | UNDEFINED | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | UNDEFINED | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | UNDEFINED | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 2337 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 50 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 5002 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| CHEMBL716 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| DB01224 | 3205 | 72 | 3H-PYRILAMINE | 1 | 62 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | ||
| 4098 | 32289 | 24 | None | 1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | None | ||
| CHEMBL1255739 | 32289 | 24 | None | 1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | None | ||
| CHEMBL1411979 | 32289 | 24 | None | 1 | 11 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 261 | 6 | 0 | 4 | 2.7 | CN(C)CCN(Cc1cccs1)c1ccccn1 | None | ||
| 1712 | 2456 | 0 | None | 1 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 4078 | 2456 | 0 | None | 1 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 7227 | 2456 | 0 | None | 1 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| CHEMBL1088 | 2456 | 0 | None | 1 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| DB00933 | 2456 | 0 | None | 1 | 21 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 386 | 4 | 0 | 4 | 4.9 | CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C | None | ||
| 1524 | 2150 | 89 | None | -2 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 197 | 2150 | 89 | None | -2 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 3822 | 2150 | 89 | None | -2 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 88 | 2150 | 89 | None | -2 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| CHEMBL51 | 2150 | 89 | None | -2 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| DB12465 | 2150 | 89 | None | -2 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 4011 | 81996 | 43 | None | 6 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | ||
| CHEMBL21731 | 81996 | 43 | None | 6 | 23 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | ||
| 1816 | 2504 | 99 | None | -3 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 4205 | 2504 | 99 | None | -3 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 7241 | 2504 | 99 | None | -3 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| CHEMBL654 | 2504 | 99 | None | -3 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| DB00370 | 2504 | 99 | None | -3 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 265 | 0 | 0 | 3 | 2.5 | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 | None | ||
| 2895 | 201898 | 35 | None | -1 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 275 | 3 | 0 | 1 | 4.6 | CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 | None | ||
| CHEMBL669 | 201898 | 35 | None | -1 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 275 | 3 | 0 | 1 | 4.6 | CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 | None | ||
| 10102 | 2509 | 83 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | None | ||
| 1824 | 2509 | 83 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | None | ||
| 65906 | 2509 | 83 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | None | ||
| CHEMBL94454 | 2509 | 83 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | None | ||
| DB12523 | 2509 | 83 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | None | ||
| 5584 | 214390 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 294 | 4 | 0 | 2 | 4.1 | CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)CN(C)C | None | ||
| 3219 | 198113 | 56 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 302 | 5 | 0 | 5 | 2.2 | CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | None | ||
| CHEMBL594 | 198113 | 56 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 302 | 5 | 0 | 5 | 2.2 | CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 | None | ||
| 2444 | 214416 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 333 | 6 | 0 | 2 | 4.1 | CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br | None | ||
| 1027 | 1546 | 67 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| 3241 | 1546 | 67 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| 7176 | 1546 | 67 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL1106 | 1546 | 67 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| DB00751 | 1546 | 67 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 249 | 0 | 2 | 1 | 2.7 | N=C1NCC2N1c1ccccc1Cc1c2cccc1 | None | ||
| 6761 | 67457 | 17 | None | -1 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
| CHEMBL1909072 | 67457 | 17 | None | -1 | 18 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 401 | 5 | 1 | 4 | 4.5 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
| 1201549 | 590 | 22 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | None | ||
| 333 | 590 | 22 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | None | ||
| 7601 | 590 | 22 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL1201203 | 590 | 22 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL438151 | 590 | 22 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | None | ||
| DB00245 | 590 | 22 | None | -1 | 20 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 307 | 4 | 0 | 2 | 4.4 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 | None | ||
| 16667681 | 214389 | 0 | 3H-trans-H2-PAT,(-) | -4 | 3 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1353 | 1880 | 85 | 3H-MEPYRAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1880 | 85 | 3H-MEPYRAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1880 | 85 | 3H-MEPYRAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1880 | 85 | 3H-MEPYRAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1880 | 85 | 3H-MEPYRAMINE | -213 | 85 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 62857 | 214427 | 0 | 3H-PYRILAMINE | -12 | 7 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 345 | 6 | 1 | 2 | 4.9 | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl | None | ||
| 24740862 | 147476 | 0 | UNDEFINED | -4 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 369 | 6 | 1 | 5 | 4.4 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F | None | ||
| CHEMBL393436 | 147476 | 0 | UNDEFINED | -4 | 5 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 369 | 6 | 1 | 5 | 4.4 | CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1F | None | ||
| 3033769 | 3229 | 54 | 3H-PYRILAMINE | -2344 | 18 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| 3033769 | 3229 | 54 | 3H-MEPYRAMINE | -2344 | 18 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| 3299 | 3229 | 54 | 3H-PYRILAMINE | -2344 | 18 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| 3299 | 3229 | 54 | 3H-MEPYRAMINE | -2344 | 18 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| 94 | 3229 | 54 | 3H-PYRILAMINE | -2344 | 18 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| 94 | 3229 | 54 | 3H-MEPYRAMINE | -2344 | 18 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| CHEMBL8809 | 3229 | 54 | 3H-PYRILAMINE | -2344 | 18 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| CHEMBL8809 | 3229 | 54 | 3H-MEPYRAMINE | -2344 | 18 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| DB12518 | 3229 | 54 | 3H-PYRILAMINE | -2344 | 18 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| DB12518 | 3229 | 54 | 3H-MEPYRAMINE | -2344 | 18 | Rat | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 346 | 5 | 2 | 4 | 2.9 | CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl | None | ||
| 13091268 | 77845 | 0 | UNDEFINED | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
| CHEMBL210578 | 77845 | 0 | UNDEFINED | -9549 | 14 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 401 | 6 | 1 | 3 | 5.0 | O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 | None | ||
| 2389 | 3279 | 114 | UNDEFINED | -331 | 67 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 5073 | 3279 | 114 | UNDEFINED | -331 | 67 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 96 | 3279 | 114 | UNDEFINED | -331 | 67 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| CHEMBL85 | 3279 | 114 | UNDEFINED | -331 | 67 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| DB00734 | 3279 | 114 | UNDEFINED | -331 | 67 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | ||
| 2995 | 202700 | 49 | 3H-Histamine | -42 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL1696 | 202700 | 49 | 3H-Histamine | -42 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| CHEMBL72 | 202700 | 49 | 3H-Histamine | -42 | 22 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 266 | 4 | 1 | 2 | 3.5 | CNCCCN1c2ccccc2CCc2ccccc21 | None | ||
| 46780481 | 107045 | 18 | None | -13 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 9903970 | 107045 | 18 | None | -13 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3187365 | 107045 | 18 | None | -13 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3544974 | 107045 | 18 | None | -13 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 2726 | 906 | 64 | 3H-MEPYRAMINE | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 2726 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-MEPYRAMINE | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-MEPYRAMINE | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-MEPYRAMINE | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-MEPYRAMINE | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | 3H-doxepin | -2 | 72 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| None | 214420 | 0 | 3H-MEPYRAMINE | -1 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 3 | 0 | 2 | 3.7 | CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl | None | ||
| 135 | 2496 | 38 | None | -1 | 57 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 2726 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 621 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 83 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL71 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB00477 | 906 | 64 | UNDEFINED | -2 | 72 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | None | ||
| 1228 | 3805 | 31 | 3H-MEPYRAMINE | -10 | 4 | Mouse | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | 3H-MEPYRAMINE | -10 | 4 | Mouse | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | 3H-MEPYRAMINE | -10 | 4 | Mouse | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | 3H-MEPYRAMINE | -10 | 4 | Mouse | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | 3H-MEPYRAMINE | -10 | 4 | Mouse | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | None | ||
| 21855 | 83830 | 35 | None | 7 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 292 | 5 | 0 | 2 | 4.1 | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | None | ||
| CHEMBL22108 | 83830 | 35 | None | 7 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 292 | 5 | 0 | 2 | 4.1 | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 | None | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 103 | 4089 | 56 | None | -1 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 2875 | 4089 | 56 | None | -1 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 5736 | 4089 | 56 | None | -1 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| CHEMBL285802 | 4089 | 56 | None | -1 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| DB09225 | 4089 | 56 | None | -1 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | ||
| 135 | 2496 | 38 | None | -1 | 57 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 1796 | 2496 | 38 | None | -1 | 57 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 4184 | 2496 | 38 | None | -1 | 57 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| CHEMBL6437 | 2496 | 38 | None | -1 | 57 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| DB06148 | 2496 | 38 | None | -1 | 57 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | ||
| 72287 | 214391 | 0 | None | 6 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 328 | 5 | 0 | 4 | 4.5 | CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C | None | ||
| 2435 | 3533 | 78 | None | -95 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 60149 | 3533 | 78 | None | -95 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 98 | 3533 | 78 | None | -95 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| CHEMBL12713 | 3533 | 78 | None | -95 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| DB06144 | 3533 | 78 | None | -95 | 48 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | ||
| 180 | 397 | 50 | None | -1 | 38 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 200 | 397 | 50 | None | -1 | 38 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 2160 | 397 | 50 | None | -1 | 38 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| CHEMBL629 | 397 | 50 | None | -1 | 38 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| DB00321 | 397 | 50 | None | -1 | 38 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | ||
| 62865 | 1248 | 0 | 3H-PYRILAMINE | -3 | 14 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 323 | 4 | 0 | 4 | 4.4 | N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 | None | ||
| 746 | 1248 | 0 | 3H-PYRILAMINE | -3 | 14 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 323 | 4 | 0 | 4 | 4.4 | N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 | None | ||
| 84 | 1248 | 0 | 3H-PYRILAMINE | -3 | 14 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 323 | 4 | 0 | 4 | 4.4 | N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 | None | ||
| CHEMBL2104153 | 1248 | 0 | 3H-PYRILAMINE | -3 | 14 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 323 | 4 | 0 | 4 | 4.4 | N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 | None | ||
| DB09000 | 1248 | 0 | 3H-PYRILAMINE | -3 | 14 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 323 | 4 | 0 | 4 | 4.4 | N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1 | None | ||
| 46780481 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| 9903970 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3187365 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| CHEMBL3544974 | 107045 | 18 | 3H-PYRILAMINE | -13 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | ||
| None | 214216 | 0 | 3H-MEPYRAMINE | 1 | 10 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 522 | 10 | 0 | 3 | 6.2 | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl | None | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | None | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | None | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | None | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | None | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | None | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 1530 | 2151 | 44 | None | 5 | 20 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 3827 | 2151 | 44 | None | 5 | 20 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 7206 | 2151 | 44 | None | 5 | 20 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| CHEMBL534 | 2151 | 44 | None | 5 | 20 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| DB00920 | 2151 | 44 | None | 5 | 20 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | None | ||
| 135398745 | 2869 | 108 | None | -1 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 47 | 2869 | 108 | None | -1 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| CHEMBL715 | 2869 | 108 | None | -1 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| DB00334 | 2869 | 108 | None | -1 | 65 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | ||
| 1224 | 1404 | 79 | 3H-trans-H2-PAT,(-) | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 1224 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-trans-H2-PAT,(-) | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 3100 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-trans-H2-PAT,(-) | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 8980 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-trans-H2-PAT,(-) | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 916 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-trans-H2-PAT,(-) | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| CHEMBL657 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-trans-H2-PAT,(-) | 1 | 13 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| DB01075 | 1404 | 79 | 3H-MEPYRAMINE | -2 | 13 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | None | ||
| 2286 | 3134 | 48 | None | -2 | 29 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 4927 | 3134 | 48 | None | -2 | 29 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 7282 | 3134 | 48 | None | -2 | 29 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| CHEMBL643 | 3134 | 48 | None | -2 | 29 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| DB01069 | 3134 | 48 | None | -2 | 29 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | None | ||
| 1238 | 201484 | 21 | None | -38 | 16 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
| CHEMBL64249 | 201484 | 21 | None | -38 | 16 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 344 | 1 | 0 | 3 | 4.3 | CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 | None | ||
| 1225 | 1443 | 24 | None | -1 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 3958 | 1443 | 24 | None | -1 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 667477 | 1443 | 24 | None | -1 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| CHEMBL860 | 1443 | 24 | None | -1 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| DB01142 | 1443 | 24 | None | -1 | 21 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | None | ||
| 1228 | 3805 | 31 | None | -5 | 4 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 2763 | 3805 | 31 | None | -5 | 4 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 5282443 | 3805 | 31 | None | -5 | 4 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| CHEMBL855 | 3805 | 31 | None | -5 | 4 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| DB00427 | 3805 | 31 | None | -5 | 4 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | None | ||
| 134 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | 3H-MEPYRAMINE | -933 | 67 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 114743 | 214331 | 0 | 3H-PYRILAMINE | -5 | 8 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 291 | 1 | 1 | 1 | 4.9 | C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N | None | ||
| 10065083 | 31887 | 1 | UNDEFINED | -141 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | None | ||
| CHEMBL140872 | 31887 | 1 | UNDEFINED | -141 | 10 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 328 | 6 | 0 | 5 | 2.4 | O=C(CCCN1CCN(c2ncccn2)CC1)c1ccc(F)cc1 | None | ||
| 46882133 | 5731 | 0 | UNDEFINED | -5 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 478 | 9 | 2 | 7 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC | None | ||
| CHEMBL1078896 | 5731 | 0 | UNDEFINED | -5 | 7 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 478 | 9 | 2 | 7 | 5.1 | CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC | None | ||
| 1209 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 203 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 3386 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| CHEMBL41 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| DB00472 | 1628 | 69 | 3H-PYRILAMINE | -223 | 31 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | None | ||
| 44350664 | 117646 | 0 | UNDEFINED | -9 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
| CHEMBL340816 | 117646 | 0 | UNDEFINED | -9 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
| CHEMBL553417 | 117646 | 0 | UNDEFINED | -9 | 6 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 351 | 6 | 0 | 2 | 5.2 | O=C(CCCN1C2CCC1CC(c1ccccc1)C2)c1ccc(F)cc1 | None | ||
| 16667681 | 214389 | 0 | 3H-MEPYRAMINE | -4 | 3 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 390 | 7 | 1 | 5 | 3.5 | CN(C)CCCC1=CC=CC=N1.C1=CC(=CC=C1OC(=O)C=CC(=O)O)Cl | None | ||
| 1204 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1247 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 1375 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 774 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| CHEMBL90 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| DB05381 | 1901 | 114 | 3H-trans-H2-PAT,(-) | -46 | 23 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | None | ||
| 180 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 16782354 | ||
| 200 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 16782354 | ||
| 2160 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 16782354 | ||
| CHEMBL629 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 16782354 | ||
| DB00321 | 397 | 50 | None | -1 | 38 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 16782354 | ||
| 11753159 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 23031591 | ||
| 7679 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 23031591 | ||
| CHEMBL2158814 | 542 | 3 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | 525 | 5 | 1 | 5 | 4.7 | Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl | 23031591 | ||
| 11579 | 628 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | 16274260 | ||
| 185460 | 628 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | 16274260 | ||
| CHEMBL1742423 | 628 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | 16274260 | ||
| DB11591 | 628 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 463 | 10 | 1 | 5 | 4.9 | CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C | 16274260 | ||
| 2749 | 341 | 0 | None | 1 | 2 | Bovine | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | 2884340 | ||
| 5574 | 341 | 0 | None | 1 | 2 | Bovine | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | 2884340 | ||
| 7237 | 341 | 0 | None | 1 | 2 | Bovine | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | 2884340 | ||
| CHEMBL829 | 341 | 0 | None | 1 | 2 | Bovine | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | 2884340 | ||
| DB01246 | 341 | 0 | None | 1 | 2 | Bovine | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 298 | 4 | 0 | 3 | 4.5 | CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C | 2884340 | ||
| 10102 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 19553115 | ||
| 1824 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 19553115 | ||
| 65906 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 19553115 | ||
| CHEMBL94454 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 19553115 | ||
| DB12523 | 2509 | 83 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 432 | 5 | 1 | 6 | 3.4 | Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C | 19553115 | ||
| 277 | 1274 | 55 | None | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 7925364 | ||
| 2913 | 1274 | 55 | None | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 7925364 | ||
| 765 | 1274 | 55 | None | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 7925364 | ||
| CHEMBL516 | 1274 | 55 | None | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 7925364 | ||
| DB00434 | 1274 | 55 | None | -2 | 45 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | 7925364 | ||
| 26987 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| 6063 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| 671 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| CHEMBL1626 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| DB00283 | 936 | 29 | None | 16 | 21 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 343 | 6 | 0 | 2 | 5.1 | Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C | None | ||
| 10447834 | 1902 | 4 | None | -1862 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 15947036 | ||
| 4026 | 1902 | 4 | None | -1862 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 15947036 | ||
| CHEMBL275507 | 1902 | 4 | None | -1862 | 6 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | 305 | 7 | 2 | 2 | 3.7 | NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 15947036 | ||
| 5048 | 3084 | 57 | None | -109 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 26084539 | ||
| 8924 | 3084 | 57 | None | -109 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 26084539 | ||
| 9948102 | 3084 | 57 | None | -109 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 26084539 | ||
| CHEMBL462605 | 3084 | 57 | None | -109 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 26084539 | ||
| DB11642 | 3084 | 57 | None | -109 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 295 | 8 | 0 | 2 | 4.2 | Clc1ccc(cc1)CCCOCCCN1CCCCC1 | 26084539 | ||
| 10403687 | 2475 | 2 | None | -331 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 12626648 | ||
| 1205 | 2475 | 2 | None | -331 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 12626648 | ||
| CHEMBL275035 | 2475 | 2 | None | -331 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | 319 | 8 | 2 | 2 | 3.9 | CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 | 12626648 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 1215 | 2052 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 150716 | 2052 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 28145930 | 2052 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| CHEMBL1334217 | 2052 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 10104 | 3510 | 7 | None | -2 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 292 | 5 | 0 | 2 | 4.1 | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C | 12593665 | ||
| 6604866 | 3510 | 7 | None | -2 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 292 | 5 | 0 | 2 | 4.1 | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C | 12593665 | ||
| CHEMBL1493369 | 3510 | 7 | None | -2 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | Guide to Pharmacology | 292 | 5 | 0 | 2 | 4.1 | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C | 12593665 | ||
| 2600 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 19660947 | ||
| 2608 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 19660947 | ||
| 5405 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 19660947 | ||
| CHEMBL17157 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 19660947 | ||
| DB00342 | 3720 | 73 | None | 1 | 13 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 471 | 8 | 2 | 3 | 6.4 | OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O | 19660947 | ||
| 1605 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 15771458 | ||
| 3957 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 15771458 | ||
| 7216 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 15771458 | ||
| CHEMBL998 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 15771458 | ||
| DB00455 | 2310 | 110 | None | -2 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 382 | 1 | 0 | 3 | 4.9 | CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 15771458 | ||
| 1170 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 19660947 | ||
| 3348 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 19660947 | ||
| 4819 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 19660947 | ||
| 74685737 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 19660947 | ||
| CHEMBL914 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 19660947 | ||
| DB00950 | 1603 | 71 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 501 | 10 | 3 | 4 | 5.5 | OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C | 19660947 | ||
| 1224 | 1404 | 79 | None | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 12065734 | ||
| 3100 | 1404 | 79 | None | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 12065734 | ||
| 8980 | 1404 | 79 | None | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 12065734 | ||
| 916 | 1404 | 79 | None | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 12065734 | ||
| CHEMBL657 | 1404 | 79 | None | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 12065734 | ||
| DB01075 | 1404 | 79 | None | -2 | 13 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 255 | 6 | 0 | 2 | 3.4 | CN(CCOC(c1ccccc1)c1ccccc1)C | 12065734 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 21381763 | ||
| 1222 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 7925364 | ||
| 2678 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 7925364 | ||
| 581 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 7925364 | ||
| CHEMBL1000 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 7925364 | ||
| DB00341 | 868 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 7925364 | ||
| 6726 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 7151 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 749 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| CHEMBL648 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| DB01176 | 1254 | 46 | None | 3 | 13 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 266 | 3 | 0 | 2 | 3.0 | CN1CCN(CC1)C(c1ccccc1)c1ccccc1 | None | ||
| 5282426 | 1438 | 0 | None | 4 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 295 | 3 | 0 | 2 | 4.7 | CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C | 10379421 | ||
| 7549 | 1438 | 0 | None | 4 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 295 | 3 | 0 | 2 | 4.7 | CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C | 10379421 | ||
| CHEMBL108947 | 1438 | 0 | None | 4 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 295 | 3 | 0 | 2 | 4.7 | CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C | 10379421 | ||
| 11976 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 19091563 | ||
| 667467 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 19091563 | ||
| CHEMBL908 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 19091563 | ||
| DB01239 | 907 | 54 | None | -4 | 23 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 19091563 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 1210 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 1213 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 2725 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 33036 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 4411 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 616 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 6976 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 716121 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| 90475904 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| CHEMBL1201353 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| CHEMBL1554789 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| CHEMBL505 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| DB01114 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 12065734 | ||
| DB13679 | 905 | 45 | None | -12 | 20 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 274 | 5 | 0 | 2 | 3.8 | CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C | 7925364 | ||
| 1214 | 2037 | 51 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 1549000 | 2037 | 51 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 1566 | 2037 | 51 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 28145931 | 2037 | 51 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| CHEMBL1201191 | 2037 | 51 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| DB06282 | 2037 | 51 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 388 | 8 | 1 | 4 | 3.1 | OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1 | 15206929 | ||
| 2247 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 12747773 | ||
| 249 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 12747773 | ||
| 2603 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 12747773 | ||
| CHEMBL296419 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 12747773 | ||
| DB00637 | 502 | 77 | None | -4 | 41 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | 12747773 | ||
| 1530 | 2151 | 44 | None | -5 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 21470866 | ||
| 3827 | 2151 | 44 | None | -5 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 21470866 | ||
| 7206 | 2151 | 44 | None | -5 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 21470866 | ||
| CHEMBL534 | 2151 | 44 | None | -5 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 21470866 | ||
| DB00920 | 2151 | 44 | None | -5 | 20 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 21470866 | ||
| 1400 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 11809864 | ||
| 3658 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 11809864 | ||
| 7199 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 11809864 | ||
| 91513 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 11809864 | ||
| CHEMBL896 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 11809864 | ||
| DB00557 | 1926 | 64 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 374 | 8 | 1 | 4 | 3.1 | OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1 | 11809864 | ||
| 1228 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 12065734 | ||
| 1228 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 7925364 | ||
| 2763 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 12065734 | ||
| 2763 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 7925364 | ||
| 5282443 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 12065734 | ||
| 5282443 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 7925364 | ||
| CHEMBL855 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 12065734 | ||
| CHEMBL855 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 7925364 | ||
| DB00427 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 12065734 | ||
| DB00427 | 3805 | 31 | None | -5 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 278 | 4 | 0 | 2 | 3.9 | Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 | 7925364 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 12065734 | ||
| 1227 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 15206929 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 12065734 | ||
| 2331 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 15206929 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 12065734 | ||
| 3957 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 15206929 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 12065734 | ||
| 4992 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 15206929 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 12065734 | ||
| CHEMBL511 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 15206929 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 12065734 | ||
| DB06691 | 2454 | 35 | None | -2 | 11 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 285 | 7 | 0 | 4 | 2.7 | COc1ccc(cc1)CN(c1ccccn1)CCN(C)C | 15206929 | ||
| 2267 | 553 | 64 | None | 10 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 21381763 | ||
| 271 | 553 | 64 | None | 10 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 21381763 | ||
| 7121 | 553 | 64 | None | 10 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 21381763 | ||
| CHEMBL639 | 553 | 64 | None | 10 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 21381763 | ||
| DB00972 | 553 | 64 | None | 10 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 381 | 3 | 0 | 4 | 4.3 | CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 | 21381763 | ||
| 124087 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 15482930 | ||
| 7157 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 15482930 | ||
| 814 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 15482930 | ||
| CHEMBL1172 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 15482930 | ||
| DB00967 | 1362 | 106 | None | 3 | 15 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 310 | 0 | 1 | 2 | 4.0 | Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 | 15482930 | ||
| 2286 | 3134 | 48 | None | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 16782354 | ||
| 4927 | 3134 | 48 | None | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 16782354 | ||
| 7282 | 3134 | 48 | None | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 16782354 | ||
| CHEMBL643 | 3134 | 48 | None | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 16782354 | ||
| DB01069 | 3134 | 48 | None | -2 | 29 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 284 | 3 | 0 | 3 | 4.2 | CN(C(CN1c2ccccc2Sc2c1cccc2)C)C | 16782354 | ||
| 10103 | 3363 | 66 | None | -25 | 3 | Guinea pig | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 8996188 | ||
| 133017 | 3363 | 66 | None | -25 | 3 | Guinea pig | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 8996188 | ||
| 2413 | 3363 | 66 | None | -25 | 3 | Guinea pig | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 8996188 | ||
| CHEMBL91397 | 3363 | 66 | None | -25 | 3 | Guinea pig | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 8996188 | ||
| DB11614 | 3363 | 66 | None | -25 | 3 | Guinea pig | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 415 | 2 | 0 | 3 | 5.6 | Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 | 8996188 | ||
| 1265 | 929 | 54 | None | -17782 | 8 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 270 | 7 | 1 | 3 | 3.0 | O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1 | 26084539 | ||
| 6422124 | 929 | 54 | None | -17782 | 8 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 270 | 7 | 1 | 3 | 3.0 | O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1 | 26084539 | ||
| CHEMBL14638 | 929 | 54 | None | -17782 | 8 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 270 | 7 | 1 | 3 | 3.0 | O=C(c1ccc(cc1)OCCCc1[nH]cnc1)C1CC1 | 26084539 | ||
| 441082 | 1140 | 40 | None | -2137 | 8 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 356 | 1 | 0 | 2 | 4.8 | CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C | 26084539 | ||
| 8981 | 1140 | 40 | None | -2137 | 8 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 356 | 1 | 0 | 2 | 4.8 | CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C | 26084539 | ||
| CHEMBL191703 | 1140 | 40 | None | -2137 | 8 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 356 | 1 | 0 | 2 | 4.8 | CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C | 26084539 | ||
| 117072554 | 1992 | 0 | None | -1995 | 4 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 450 | 5 | 2 | 6 | 2.3 | CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1 | 26084539 | ||
| 8982 | 1992 | 0 | None | -1995 | 4 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 450 | 5 | 2 | 6 | 2.3 | CN1CCN(CC1)C1=CC(=NC(N1)N)c1ccc2c(c1)CN(CC2)C(=O)CCC1CCCC1 | 26084539 | ||
| 11697697 | 2510 | 19 | None | -6309 | 6 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 431 | 6 | 0 | 5 | 4.6 | Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F | 26084539 | ||
| 7346 | 2510 | 19 | None | -6309 | 6 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 431 | 6 | 0 | 5 | 4.6 | Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F | 26084539 | ||
| CHEMBL476323 | 2510 | 19 | None | -6309 | 6 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 431 | 6 | 0 | 5 | 4.6 | Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F | 26084539 | ||
| DB11910 | 2510 | 19 | None | -6309 | 6 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 431 | 6 | 0 | 5 | 4.6 | Cc1nc2cccc(c2c(=O)n1c1ccc(cc1)OCCCN1CCCC1)C(F)(F)F | 26084539 | ||
| 24994634 | 2111 | 26 | None | -194 | 7 | Human | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | 221 | 2 | 2 | 5 | 0.7 | N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C | 26084539 | ||
| 8984 | 2111 | 26 | None | -194 | 7 | Human | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | 221 | 2 | 2 | 5 | 0.7 | N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C | 26084539 | ||
| CHEMBL3236549 | 2111 | 26 | None | -194 | 7 | Human | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | 221 | 2 | 2 | 5 | 0.7 | N[C@@H]1CCN(C1)c1cc(nc(n1)N)C(C)C | 26084539 | ||
| 45257132 | 3626 | 3 | None | -83 | 4 | Human | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | 366 | 4 | 2 | 6 | 2.7 | CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N | 26084539 | ||
| 8983 | 3626 | 3 | None | -83 | 4 | Human | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | 366 | 4 | 2 | 6 | 2.7 | CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N | 26084539 | ||
| CHEMBL595180 | 3626 | 3 | None | -83 | 4 | Human | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | 366 | 4 | 2 | 6 | 2.7 | CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(n1)N | 26084539 | ||
| 3012003 | 214377 | 0 | None | -6 | 12 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 311 | 5 | 0 | 3 | 3.8 | CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3 | None | ||
| 134 | 2478 | 19 | None | -933 | 67 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 2478 | 19 | None | -933 | 67 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 2478 | 19 | None | -933 | 67 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 2478 | 19 | None | -933 | 67 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 2478 | 19 | None | -933 | 67 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 202 | 1480 | 0 | None | -1 | 31 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 60835 | 1480 | 0 | None | -1 | 31 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 972 | 1480 | 0 | None | -1 | 31 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| CHEMBL1175 | 1480 | 0 | None | -1 | 31 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| DB00476 | 1480 | 0 | None | -1 | 31 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 146570 | 43208 | 60 | None | -1 | 4 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| CHEMBL1508 | 43208 | 60 | None | -1 | 4 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 324 | 5 | 0 | 3 | 3.8 | CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 | None | ||
| 12057539 | 206301 | 39 | None | -676 | 20 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 3661 | 206301 | 39 | None | -676 | 20 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| CHEMBL9751 | 206301 | 39 | None | -676 | 20 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 289 | 4 | 1 | 4 | 1.9 | CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 | None | ||
| 5281878 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 5281881 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 948 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 968 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL42055 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| CHEMBL54661 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| DB00875 | 1630 | 33 | None | -1 | 16 | Human | 8.0 | pKi | None | 8.0 | Binding | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | ||
| 1197 | 88 | 113 | None | - | 1 | Human | 3.7 | pKi | None | 3.7 | Binding | Guide to Pharmacology | 122 | 2 | 1 | 2 | 0.6 | NCCc1ccccn1 | 15206929 | ||
| 75919 | 88 | 113 | None | - | 1 | Human | 3.7 | pKi | None | 3.7 | Binding | Guide to Pharmacology | 122 | 2 | 1 | 2 | 0.6 | NCCc1ccccn1 | 15206929 | ||
| CHEMBL32813 | 88 | 113 | None | - | 1 | Human | 3.7 | pKi | None | 3.7 | Binding | Guide to Pharmacology | 122 | 2 | 1 | 2 | 0.6 | NCCc1ccccn1 | 15206929 | ||
| 1200 | 3900 | 1 | None | -39 | 3 | Human | 4.4 | pKi | None | 4.4 | Binding | Guide to Pharmacology | 335 | 8 | 4 | 5 | 0.7 | O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C | 16394198 | ||
| 25149519 | 3900 | 1 | None | -39 | 3 | Human | 4.4 | pKi | None | 4.4 | Binding | Guide to Pharmacology | 335 | 8 | 4 | 5 | 0.7 | O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C | 16394198 | ||
| CHEMBL513056 | 3900 | 1 | None | -39 | 3 | Human | 4.4 | pKi | None | 4.4 | Binding | Guide to Pharmacology | 335 | 8 | 4 | 5 | 0.7 | O=C(NC(=NCCCc1cnc[nH]1)N)CSCc1nc[nH]c1C | 16394198 | ||
| 1199 | 2928 | 0 | None | -316 | 3 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 394 | 8 | 3 | 4 | 2.5 | NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F | 16394198 | ||
| 25149244 | 2928 | 0 | None | -316 | 3 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 394 | 8 | 3 | 4 | 2.5 | NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F | 16394198 | ||
| CHEMBL472273 | 2928 | 0 | None | -316 | 3 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 394 | 8 | 3 | 4 | 2.5 | NC(=NCCCc1[nH]cnc1)NC(=O)CC(c1ccccn1)c1ccc(cc1)F | 16394198 | ||
| 1198 | 3899 | 1 | None | - | 1 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 401 | 8 | 4 | 4 | 2.0 | O=C(CC(c1ccc(c(c1)F)F)c1ncc[nH]1)NC(=NCCCc1cnc[nH]1)N | 16394198 | ||
| 25149704 | 3899 | 1 | None | - | 1 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 401 | 8 | 4 | 4 | 2.0 | O=C(CC(c1ccc(c(c1)F)F)c1ncc[nH]1)NC(=NCCCc1cnc[nH]1)N | 16394198 | ||
| CHEMBL470563 | 3899 | 1 | None | - | 1 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 401 | 8 | 4 | 4 | 2.0 | O=C(CC(c1ccc(c(c1)F)F)c1ncc[nH]1)NC(=NCCCc1cnc[nH]1)N | 16394198 | ||
| 1201 | 3901 | 1 | None | -2 | 2 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 361 | 7 | 3 | 3 | 2.6 | O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N | 16394198 | ||
| 25150700 | 3901 | 1 | None | -2 | 2 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 361 | 7 | 3 | 3 | 2.6 | O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N | 16394198 | ||
| CHEMBL499301 | 3901 | 1 | None | -2 | 2 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 361 | 7 | 3 | 3 | 2.6 | O=C(CC(c1ccccc1)c1ccccc1)NC(=NCCc1cnc[nH]1)N | 16394198 | ||
| 1226 | 1988 | 16 | None | -354 | 6 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 321 | 9 | 4 | 4 | 1.2 | NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C | 16394198 | ||
| 41376 | 1988 | 16 | None | -354 | 6 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 321 | 9 | 4 | 4 | 1.2 | NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C | 16394198 | ||
| CHEMBL12608 | 1988 | 16 | None | -354 | 6 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 321 | 9 | 4 | 4 | 1.2 | NC(=NCCCc1cnc[nH]1)NCCSCc1nc[nH]c1C | 16394198 | ||
| 1202 | 3902 | 1 | None | - | 1 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 411 | 8 | 3 | 3 | 3.3 | O=C(CC(c1ccc(cc1)F)c1ccc(cc1)F)NC(=NCCCc1cnc[nH]1)N | 16394198 | ||
| 25150704 | 3902 | 1 | None | - | 1 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 411 | 8 | 3 | 3 | 3.3 | O=C(CC(c1ccc(cc1)F)c1ccc(cc1)F)NC(=NCCCc1cnc[nH]1)N | 16394198 | ||
| CHEMBL513883 | 3902 | 1 | None | - | 1 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 411 | 8 | 3 | 3 | 3.3 | O=C(CC(c1ccc(cc1)F)c1ccc(cc1)F)NC(=NCCCc1cnc[nH]1)N | 16394198 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12065734 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12626648 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 15206929 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 16394198 | ||
| 1204 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 7925364 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12065734 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12626648 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 15206929 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 16394198 | ||
| 1247 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 7925364 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12065734 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12626648 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 15206929 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 16394198 | ||
| 1375 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 7925364 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12065734 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12626648 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 15206929 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 16394198 | ||
| 774 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 7925364 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12065734 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12626648 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 15206929 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 16394198 | ||
| CHEMBL90 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 7925364 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12065734 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 12626648 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 15206929 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 16394198 | ||
| DB05381 | 1901 | 114 | None | -501 | 23 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 111 | 2 | 2 | 2 | -0.1 | NCCc1cnc[nH]1 | 7925364 | ||
| 1193 | 45 | 0 | None | - | 1 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 128 | 2 | 1 | 3 | 0.6 | NCCc1nccs1 | 12626648 | ||
| 87653 | 45 | 0 | None | - | 1 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 128 | 2 | 1 | 3 | 0.6 | NCCc1nccs1 | 12626648 | ||
| CHEMBL25414 | 45 | 0 | None | - | 1 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 128 | 2 | 1 | 3 | 0.6 | NCCc1nccs1 | 12626648 | ||
| 10389213 | 195 | 8 | None | -6025 | 3 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 453 | 10 | 1 | 6 | 2.6 | O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1 | 12606603 | ||
| 10389213 | 195 | 8 | None | -6025 | 3 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 453 | 10 | 1 | 6 | 2.6 | O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1 | 15294456 | ||
| 1216 | 195 | 8 | None | -6025 | 3 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 453 | 10 | 1 | 6 | 2.6 | O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1 | 12606603 | ||
| 1216 | 195 | 8 | None | -6025 | 3 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 453 | 10 | 1 | 6 | 2.6 | O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1 | 15294456 | ||
| CHEMBL361355 | 195 | 8 | None | -6025 | 3 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 453 | 10 | 1 | 6 | 2.6 | O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1 | 12606603 | ||
| CHEMBL361355 | 195 | 8 | None | -6025 | 3 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 453 | 10 | 1 | 6 | 2.6 | O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1 | 15294456 | ||
| 1217 | 197 | 0 | None | -6309 | 3 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 321 | 9 | 0 | 8 | 0.5 | CO[C@H]([C@H]([C@H](C(OC(=O)C)[2H])OC(=O)C)OC)[C@@H](OC(=O)C)C | 15294456 | ||
| 15608077 | 197 | 0 | None | -6309 | 3 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 321 | 9 | 0 | 8 | 0.5 | CO[C@H]([C@H]([C@H](C(OC(=O)C)[2H])OC(=O)C)OC)[C@@H](OC(=O)C)C | 15294456 | ||
| 1223 | 940 | 32 | None | -14125 | 11 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 308 | 6 | 2 | 3 | 3.2 | Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N | 12606603 | ||
| 2790 | 940 | 32 | None | -14125 | 11 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 308 | 6 | 2 | 3 | 3.2 | Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N | 12606603 | ||
| CHEMBL14690 | 940 | 32 | None | -14125 | 11 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 308 | 6 | 2 | 3 | 3.2 | Clc1ccc(cc1)CN=C(SCCCc1cnc[nH]1)N | 12606603 | ||
| 2181 | 3079 | 0 | None | -51 | 34 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | ||
| 4830 | 3079 | 0 | None | -51 | 34 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | ||
| 92 | 3079 | 0 | None | -51 | 34 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | ||
| CHEMBL440294 | 3079 | 0 | None | -51 | 34 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | ||
| DB09286 | 3079 | 0 | None | -51 | 34 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | 8935801 | ||
| 1194 | 46 | 3 | None | -2089 | 4 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 12626648 | ||
| 23786499 | 46 | 3 | None | -2089 | 4 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 12626648 | ||
| CHEMBL26116 | 46 | 3 | None | -2089 | 4 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 265 | 3 | 2 | 2 | 2.3 | NCCc1cnc([nH]1)c1cccc(c1)Br | 12626648 | ||
| 1195 | 47 | 5 | None | - | 1 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 221 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)Cl | 12626648 | ||
| 14827778 | 47 | 5 | None | - | 1 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 221 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)Cl | 12626648 | ||
| CHEMBL287052 | 47 | 5 | None | - | 1 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 221 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)Cl | 12626648 | ||
| 1830 | 2552 | 39 | None | -125 | 27 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | 12629531 | ||
| 207 | 2552 | 39 | None | -125 | 27 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | 12629531 | ||
| 23897 | 2552 | 39 | None | -125 | 27 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | 12629531 | ||
| CHEMBL460 | 2552 | 39 | None | -125 | 27 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | 12629531 | ||
| DB01618 | 2552 | 39 | None | -125 | 27 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 276 | 3 | 1 | 3 | 2.0 | CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 | 12629531 | ||
| 10245039 | 50 | 0 | None | - | 1 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 313 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)I | 12626648 | ||
| 1196 | 50 | 0 | None | - | 1 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 313 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)I | 12626648 | ||
| CHEMBL287367 | 50 | 0 | None | - | 1 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 313 | 3 | 2 | 2 | 2.2 | NCCc1cnc([nH]1)c1cccc(c1)I | 12626648 | ||
| 1218 | 227 | 47 | None | -891 | 4 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 330 | 4 | 0 | 3 | 5.0 | N#Cc1ccc(cc1)c1ccc2c(c1)cc(o2)CCN1CCC[C@H]1C | 15608078 | ||
| 9818903 | 227 | 47 | None | -891 | 4 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 330 | 4 | 0 | 3 | 5.0 | N#Cc1ccc(cc1)c1ccc2c(c1)cc(o2)CCN1CCC[C@H]1C | 15608078 | ||
| CHEMBL351231 | 227 | 47 | None | -891 | 4 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 330 | 4 | 0 | 3 | 5.0 | N#Cc1ccc(cc1)c1ccc2c(c1)cc(o2)CCN1CCC[C@H]1C | 15608078 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 12629531 | ||
| 1353 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8935801 | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 12629531 | ||
| 3559 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8935801 | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 12629531 | ||
| 86 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8935801 | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 12629531 | ||
| CHEMBL54 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8935801 | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 12629531 | ||
| DB00502 | 1880 | 85 | None | -489 | 85 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 8935801 | ||
| 16362 | 3076 | 67 | None | -489 | 29 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 12629531 | ||
| 2172 | 3076 | 67 | None | -489 | 29 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 12629531 | ||
| 90 | 3076 | 67 | None | -489 | 29 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 12629531 | ||
| CHEMBL1423 | 3076 | 67 | None | -489 | 29 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 12629531 | ||
| DB01100 | 3076 | 67 | None | -489 | 29 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 12629531 | ||
| 10042467 | 1398 | 1 | None | -173 | 4 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 12626648 | ||
| 1203 | 1398 | 1 | None | -173 | 4 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 12626648 | ||
| CHEMBL11553 | 1398 | 1 | None | -173 | 4 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 333 | 8 | 1 | 2 | 4.3 | CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C | 12626648 | ||
| 1221 | 472 | 9 | None | -12 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 12626648 | ||
| 1221 | 472 | 9 | None | -12 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 16394198 | ||
| 65895 | 472 | 9 | None | -12 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 12626648 | ||
| 65895 | 472 | 9 | None | -12 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 16394198 | ||
| CHEMBL293802 | 472 | 9 | None | -12 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 12626648 | ||
| CHEMBL293802 | 472 | 9 | None | -12 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 380 | 9 | 3 | 3 | 3.0 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)F | 16394198 | ||
| 1219 | 727 | 0 | None | -3 | 2 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 396 | 9 | 3 | 3 | 3.5 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl | 12626648 | ||
| 14660352 | 727 | 0 | None | -3 | 2 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 396 | 9 | 3 | 3 | 3.5 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl | 12626648 | ||
| CHEMBL304239 | 727 | 0 | None | -3 | 2 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 396 | 9 | 3 | 3 | 3.5 | NC(=NCCCc1[nH]cnc1)NCCC(c1ccccn1)c1ccc(cc1)Cl | 12626648 | ||
| 1208 | 1954 | 0 | None | - | 1 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 15657195 | 1954 | 0 | None | - | 1 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 2435 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 12629531 | ||
| 2435 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | ||
| 60149 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 12629531 | ||
| 60149 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | ||
| 98 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 12629531 | ||
| 98 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | ||
| CHEMBL12713 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 12629531 | ||
| CHEMBL12713 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | ||
| DB06144 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 12629531 | ||
| DB06144 | 3533 | 78 | None | -95 | 48 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | ||
| 214 | 3799 | 52 | None | -43 | 29 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 2740 | 3799 | 52 | None | -43 | 29 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 5566 | 3799 | 52 | None | -43 | 29 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 66064 | 3799 | 52 | None | -43 | 29 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| CHEMBL422 | 3799 | 52 | None | -43 | 29 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| DB00831 | 3799 | 52 | None | -43 | 29 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 407 | 4 | 0 | 4 | 4.9 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 10106214 | 2073 | 1 | None | -5 | 5 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 1207 | 2073 | 1 | None | -5 | 5 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 1209 | 2073 | 1 | None | -5 | 5 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| CHEMBL127307 | 2073 | 1 | None | -5 | 5 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 475100 | 188 | 0 | None | -31 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | ||
| 67 | 188 | 0 | None | -31 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | ||
| CHEMBL3542429 | 188 | 0 | None | -31 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | ||
| 242 | 467 | 117 | None | -23 | 51 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12629531 | ||
| 34 | 467 | 117 | None | -23 | 51 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12629531 | ||
| 60795 | 467 | 117 | None | -23 | 51 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12629531 | ||
| CHEMBL1112 | 467 | 117 | None | -23 | 51 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12629531 | ||
| DB01238 | 467 | 117 | None | -23 | 51 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 12629531 | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 12629531 | ||
| 2865 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 12629531 | ||
| 59 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 12629531 | ||
| 60854 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 12629531 | ||
| CHEMBL708 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 12629531 | ||
| DB00246 | 4079 | 67 | None | -61 | 53 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 12629531 | ||
| 2389 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 12629531 | ||
| 5073 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 12629531 | ||
| 96 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 12629531 | ||
| CHEMBL85 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 12629531 | ||
| DB00734 | 3279 | 114 | None | -44 | 67 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | ||
| 1212 | 1632 | 45 | None | -41 | 65 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 204 | 1632 | 45 | None | -41 | 65 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 3372 | 1632 | 45 | None | -41 | 65 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| CHEMBL726 | 1632 | 45 | None | -41 | 65 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| DB00623 | 1632 | 45 | None | -41 | 65 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 12629531 | ||
| 100 | 3745 | 52 | None | -7 | 55 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 12629531 | ||
| 2637 | 3745 | 52 | None | -7 | 55 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 12629531 | ||
| 5452 | 3745 | 52 | None | -7 | 55 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 12629531 | ||
| CHEMBL479 | 3745 | 52 | None | -7 | 55 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 12629531 | ||
| DB00679 | 3745 | 52 | None | -7 | 55 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 12629531 | ||
| 10037815 | 3092 | 0 | None | - | 1 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| 1206 | 3092 | 0 | None | - | 1 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| CHEMBL340199 | 3092 | 0 | None | - | 1 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| 1222 | 1634 | 44 | None | -17 | 32 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | ||
| 3396 | 1634 | 44 | None | -17 | 32 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | ||
| 85 | 1634 | 44 | None | -17 | 32 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | ||
| CHEMBL46516 | 1634 | 44 | None | -17 | 32 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | ||
| DB04842 | 1634 | 44 | None | -17 | 32 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | ||
| 209 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 12629531 | ||
| 2113 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 12629531 | ||
| 4748 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 12629531 | ||
| CHEMBL567 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 12629531 | ||
| DB00850 | 3008 | 94 | None | -11 | 23 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 12629531 | ||
| 10037815 | 3092 | 0 | None | - | 1 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| 1206 | 3092 | 0 | None | - | 1 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| CHEMBL340199 | 3092 | 0 | None | - | 1 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| 2726 | 906 | 64 | None | -2 | 72 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 12629531 | ||
| 621 | 906 | 64 | None | -2 | 72 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 12629531 | ||
| 83 | 906 | 64 | None | -2 | 72 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 12629531 | ||
| CHEMBL71 | 906 | 64 | None | -2 | 72 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 12629531 | ||
| DB00477 | 906 | 64 | None | -2 | 72 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 12629531 | ||
| 1613 | 2316 | 44 | None | -3 | 44 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 12629531 | ||
| 205 | 2316 | 44 | None | -3 | 44 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 12629531 | ||
| 3964 | 2316 | 44 | None | -3 | 44 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 12629531 | ||
| CHEMBL831 | 2316 | 44 | None | -3 | 44 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 12629531 | ||
| DB00408 | 2316 | 44 | None | -3 | 44 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 12629531 | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 12629531 | ||
| 2337 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 12629531 | ||
| 50 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 12629531 | ||
| 5002 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 12629531 | ||
| CHEMBL716 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 12629531 | ||
| DB01224 | 3205 | 72 | None | 1 | 62 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | ||
| 212 | 3746 | 43 | None | -5 | 25 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 12629531 | ||
| 2639 | 3746 | 43 | None | -5 | 25 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 12629531 | ||
| 941651 | 3746 | 43 | None | -5 | 25 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 12629531 | ||
| CHEMBL1201 | 3746 | 43 | None | -5 | 25 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 12629531 | ||
| DB01623 | 3746 | 43 | None | -5 | 25 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | 12629531 | ||
| 10106214 | 2073 | 1 | None | -5 | 5 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 1207 | 2073 | 1 | None | -5 | 5 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 1209 | 2073 | 1 | None | -5 | 5 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| CHEMBL127307 | 2073 | 1 | None | -5 | 5 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C | 12065734 | ||
| 10015055 | 2072 | 4 | None | 15 | 5 | Human | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| 1212 | 2072 | 4 | None | 15 | 5 | Human | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| CHEMBL3402679 | 2072 | 4 | None | 15 | 5 | Human | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 251 | 2 | 0 | 1 | 3.7 | CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C | 12065734 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 12629531 | ||
| 135398745 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 12629531 | ||
| 47 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 12629531 | ||
| CHEMBL715 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 12629531 | ||
| DB00334 | 2869 | 108 | None | 1 | 65 | Human | 9.0 | pKi | None | 9.0 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12065734 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12629531 | ||
| 135398737 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12065734 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12629531 | ||
| 38 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12065734 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12629531 | ||
| 722 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12065734 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12629531 | ||
| CHEMBL42 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12065734 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 12629531 | ||
| DB00363 | 944 | 89 | None | 2 | 91 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | ||
| 103 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
| 2875 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
| 5736 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
| CHEMBL285802 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
| DB09225 | 4089 | 56 | None | -1 | 53 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | ||
| 1225 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 12065734 | ||
| 3958 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 12065734 | ||
| 667477 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 12065734 | ||
| CHEMBL860 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 12065734 | ||
| DB01142 | 1443 | 24 | None | -1 | 21 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 279 | 3 | 0 | 2 | 4.0 | CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C | 12065734 | ||
| 163091 | 491 | 30 | None | -6 | 10 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | ||
| 22 | 491 | 30 | None | -6 | 10 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | ||
| CHEMBL504548 | 491 | 30 | None | -6 | 10 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | ||