Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1481 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| 3749 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| 3749.0 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| 589 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| 6908 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1513 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| DB01029 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
| 40466887 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.4 | 5.4 | - | 1 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
| 5362124 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.4 | 5.4 | - | 1 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
| CHEMBL838 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.4 | 5.4 | - | 1 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
| 1610 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3941 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3961 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3961.0 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 590 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| DB00678 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 158781 | 44180 | None | 60 | Human | Functional | pAC50 | = | 4.3 | 4.3 | -95499 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1516 | 44180 | None | 60 | Human | Functional | pAC50 | = | 4.3 | 4.3 | -95499 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 1610 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3941 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3961 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3961.0 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 590 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| DB00678 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 1610 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3941 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3961 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 3961.0 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 590 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| DB00678 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
| 130881 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
| 130881.0 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
| 1985 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
| 591 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1200692 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
| DB00275 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
| 40466887 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.1 | 5.1 | - | 1 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
| 5362124 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.1 | 5.1 | - | 1 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
| CHEMBL838 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.1 | 5.1 | - | 1 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
| 2541 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| 2541.0 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| 587 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| 6907 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1016 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| DB00796 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| DB13919 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
| 3033 | 30160 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -8709 | 4 | Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method |
ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | ||
Showing 1 to 50 of 226 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 44348523 | 113242 | None | 0 | Rat | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL331450 | 113242 | None | 0 | Rat | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| 11930 | 1019 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 2 | Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane |
ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | ||
| 15780052 | 1019 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 2 | Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane |
ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | ||
| CHEMBL289472 | 1019 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 2 | Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane |
ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | ||
| 10033116 | 210695 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. |
ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
| CHEMBL98665 | 210695 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. |
ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
| 11765177 | 117072 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL338888 | 117072 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| 16133225 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 172198 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 172198.0 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 2504 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 45266664 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 5272 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| DB11842 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| CHEMBL385433 | 214810 | None | 1 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | Displacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cells |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2016.03.006 | ||||
| 10259841 | 16165 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL122401 | 16165 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| 10417195 | 109135 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain |
ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| CHEMBL321313 | 109135 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain |
ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| 10078554 | 117032 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL338687 | 117032 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| 10440174 | 167917 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. |
ChEMBL | 767 | 17 | 1 | 9 | 8.0 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
| CHEMBL430659 | 167917 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. |
ChEMBL | 767 | 17 | 1 | 9 | 8.0 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
| CHEMBL385189 | 214803 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes. |
ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O | 10.1021/jm00108a043 | ||||
| 10078800 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues |
ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| CHEMBL321531 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues |
ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| 9853391 | 116903 | None | 1 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL338027 | 116903 | None | 1 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| 9853391 | 116903 | None | 1 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2 |
ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | ||
| CHEMBL338027 | 116903 | None | 1 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2 |
ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | ||
| CHEMBL2391146 | 212871 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | Binding affinity to human angiotensin AT2 receptor by radioligand displacement assayBinding affinity to human angiotensin AT2 receptor by radioligand displacement assay |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2013.03.016 | ||||
| 10101351 | 168767 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
| CHEMBL436396 | 168767 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
| 10259525 | 15626 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
| CHEMBL122158 | 15626 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
| 10372810 | 106258 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain |
ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| CHEMBL313868 | 106258 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain |
ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| 10078800 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain |
ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| CHEMBL321531 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain |
ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
| 10395335 | 117146 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
| CHEMBL339256 | 117146 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
| 10033136 | 16080 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL122380 | 16080 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations. |
ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| 19430477 | 210590 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. |
ChEMBL | 732 | 18 | 1 | 8 | 8.1 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 | 10.1021/jm00015a016 | ||
| CHEMBL98047 | 210590 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. |
ChEMBL | 732 | 18 | 1 | 8 | 8.1 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 | 10.1021/jm00015a016 | ||
| 10259468 | 118545 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
| CHEMBL341369 | 118545 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations. |
ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
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