Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL1408432 galr2_human Human Yes 4.3 EC50 = 45422 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]
360 6 1 5 3.8 C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1
CHEMBL4128926 galr2_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysis
583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
CHEMBL501079 galr2_human Human Yes 9.1 IC50 = 0.8 nM Bind
Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL1447697 galr2_human Human Yes 5.0 IC50 = 10320 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
297 5 1 7 1.6 CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O
CHEMBL1921997 galr2_human Human No 6.0 IC50 = 1060 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
473 8 3 7 6.6 COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1
CHEMBL1921902 galr2_human Human No 6.0 IC50 = 1090 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
375 6 2 6 5.0 COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1
CHEMBL1586531 galr2_human Human Yes 5.0 IC50 = 10900 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
265 4 1 4 2.9 O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1
CHEMBL309016 galr2_human Human Yes 5.0 IC50 = 11080 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
195 3 1 4 1.6 COc1cc(/C=C/[N+](=O)[O-])ccc1O
CHEMBL1922004 galr2_human Human No 5.9 IC50 = 1180 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
403 6 2 6 5.6 COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1
CHEMBL1921995 galr2_human Human No 4.9 IC50 = 12500 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
455 9 3 7 6.3 COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1
CHEMBL1585420 galr2_human Human Yes 5.9 IC50 = 1289 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
278 4 2 8 1.5 CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC
CHEMBL1922019 galr2_human Human No 5.9 IC50 = 1340 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
437 7 2 7 5.4 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1
CHEMBL1458812 galr2_human Human Yes 4.8 IC50 = 14420 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
306 4 0 6 2.9 CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12
CHEMBL1586531 galr2_human Human Yes 4.8 IC50 = 16970 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
265 4 1 4 2.9 O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1
CHEMBL1458812 galr2_human Human Yes 4.8 IC50 = 17070 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
306 4 0 6 2.9 CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12
CHEMBL1374788 galr2_human Human Yes 4.8 IC50 = 17100 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O
CHEMBL1921998 galr2_human Human No 5.8 IC50 = 1750 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
419 8 3 7 5.7 COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1
CHEMBL1531933 galr2_human Human Yes 4.8 IC50 = 17900 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1
CHEMBL1922000 galr2_human Human No 5.7 IC50 = 1920 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
527 6 1 8 5.4 COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1
CHEMBL1922011 galr2_human Human No 5.7 IC50 = 1930 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
457 7 2 6 5.9 COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1
CHEMBL501079 galr2_human Human Yes 8.6 IC50 = 2.6 nM Bind
Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL506553 galr2_human Human Yes 8.6 IC50 = 2.6 nM Bind
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
None None None None
CHEMBL1922002 galr2_human Human No 5.7 IC50 = 2030 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
545 6 1 8 5.5 COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F
CHEMBL1922001 galr2_human Human No 5.7 IC50 = 2080 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
525 5 1 7 6.0 Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1
CHEMBL475562 galr2_rat Rat Yes 7.7 IC50 = 21.1 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
395 9 2 4 3.9 N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O
CHEMBL1531933 galr2_human Human Yes 4.7 IC50 = 21410 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1
CHEMBL514318 galr2_rat Rat No 6.7 IC50 = 226 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC1=O
CHEMBL475845 galr2_rat Rat No 5.7 IC50 = 2260 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](CS(=O)(=O)O)C(C)=O)NC(=O)[C@H]([C@@H](C)CC)NC1=O
CHEMBL1922023 galr2_human Human No 4.6 IC50 = 24850 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
500 8 2 8 5.4 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1
CHEMBL515145 galr2_rat Rat No 6.6 IC50 = 278 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC1=O
CHEMBL1922017 galr2_human Human No 5.5 IC50 = 2850 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
411 9 2 7 5.0 CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1
CHEMBL501079 galr2_human Human Yes 8.5 IC50 = 3.5 nM Bind
Displacement of radiolabeled galanin from human galanin 2 receptorDisplacement of radiolabeled galanin from human galanin 2 receptor
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL501079 galr2_human Human Yes 8.5 IC50 = 3.5 nM Bind
Inhibition of human GAL2 receptorInhibition of human GAL2 receptor
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL1922007 galr2_human Human No 6.5 IC50 = 330 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
459 7 2 7 5.9 COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1
CHEMBL1921988 galr2_human Human No 5.5 IC50 = 3380 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
411 7 2 6 5.6 FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1
CHEMBL1921992 galr2_human Human No 5.5 IC50 = 3400 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
430 6 1 7 4.2 COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1
CHEMBL1921990 galr2_human Human No 5.4 IC50 = 3690 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
403 6 2 7 4.6 c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1
CHEMBL1922006 galr2_human Human No 6.4 IC50 = 380 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
459 7 2 7 5.9 COc1ccc(Nc2nc(Nc3cccc(OC(F)(F)F)c3)cc(N3CCCCC3)n2)cc1
CHEMBL1922013 galr2_human Human No 6.4 IC50 = 380 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
407 6 2 6 5.4 COc1ccc(Nc2nc(Nc3cccc(F)c3C)cc(N3CCCCC3)n2)cc1
CHEMBL1921989 galr2_human Human No 5.4 IC50 = 4150 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
411 7 2 6 5.6 FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1
CHEMBL1922014 galr2_human Human No 5.4 IC50 = 4180 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
427 6 2 6 5.8 COc1ccc(Nc2nc(Nc3ccc(F)c(Cl)c3)cc(N3CCCCC3)n2)cc1
CHEMBL1922010 galr2_human Human No 6.4 IC50 = 430 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
423 7 2 7 5.1 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCC3)n2)cc1
CHEMBL1922005 galr2_human Human No 6.4 IC50 = 440 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
403 6 2 6 5.6 COc1ccc(Nc2nc(Nc3cc(C)ccc3C)cc(N3CCCCC3)n2)cc1
CHEMBL474037 galr2_rat Rat No 6.4 IC50 = 450 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC1=O
CHEMBL1482215 galr2_human Human Yes 4.3 IC50 = 45250 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
337 3 2 5 5.4 Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12
CHEMBL1342746 galr2_human Human No 4.3 IC50 = 45640 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
343 2 1 5 2.5 CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1
CHEMBL1921901 galr2_human Human No 5.3 IC50 = 4570 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
373 5 2 5 5.6 Cc1ccc(C)c(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1
CHEMBL1540377 galr2_human Human Yes 5.3 IC50 = 5371 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1
CHEMBL1922009 galr2_human Human No 6.3 IC50 = 540 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
441 8 2 7 5.6 COc1ccc(Nc2nc(Nc3cccc(OC(F)F)c3)cc(N3CCCCC3)n2)cc1
CHEMBL474038 galr2_rat Rat No 6.3 IC50 = 542 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O
CHEMBL1921999 galr2_human Human No 6.3 IC50 = 550 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
473 8 3 7 6.6 COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1
CHEMBL1922003 galr2_human Human No 6.3 IC50 = 560 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
529 5 1 7 5.8 Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1
CHEMBL473840 galr2_rat Rat No 6.2 IC50 = 574 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O
CHEMBL1921903 galr2_human Human No 5.2 IC50 = 6620 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
429 6 2 6 5.9 FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1
CHEMBL1432794 galr2_human Human Yes 5.2 IC50 = 6765 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
425 5 3 4 4.7 O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1
CHEMBL1447697 galr2_human Human Yes 5.1 IC50 = 7528 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
297 5 1 7 1.6 CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O
CHEMBL1374788 galr2_human Human Yes 5.1 IC50 = 7616 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O
CHEMBL1921996 galr2_human Human No 6.1 IC50 = 770 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
455 9 3 7 6.3 COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1
CHEMBL1922016 galr2_human Human No 6.1 IC50 = 770 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
437 7 2 7 5.5 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1
CHEMBL1922008 galr2_human Human No 6.1 IC50 = 780 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
443 6 2 6 6.0 COc1ccc(Nc2nc(Nc3ccc(C(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1
CHEMBL1921994 galr2_human Human No 5.1 IC50 = 8040 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
391 7 2 7 4.6 COc1ccc(Nc2cc(Nc3ccc(OC)cc3)nc(N3CCCC3)n2)cc1
CHEMBL1921991 galr2_human Human No 5.1 IC50 = 8650 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
393 6 2 6 5.1 COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F
CHEMBL451169 galr2_rat Rat No 7.1 IC50 = 87.7 nM Bind
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCC(C)=O)NC(=O)[C@H]2CCCCN2C1=O
CHEMBL1451772 galr2_human Human Yes 5.1 IC50 = 8838 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
326 3 1 4 3.7 CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1
CHEMBL1400481 galr2_human Human Yes 5.1 IC50 = 8959 nM Funct
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
252 3 0 7 2.0 O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1
CHEMBL1922025 galr2_human Human No 5.0 IC50 = 9070 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
538 7 2 9 5.6 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1
CHEMBL1921993 galr2_human Human No 6.0 IC50 = 930 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
391 7 2 7 4.6 COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1
CHEMBL1400481 galr2_human Human Yes 5.0 IC50 = 9608 nM Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
252 3 0 7 2.0 O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1
CHEMBL1922012 galr2_human Human No 6.0 IC50 = 980 nM Bind
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
407 6 2 6 5.4 COc1ccc(Nc2nc(Nc3ccc(F)cc3C)cc(N3CCCCC3)n2)cc1
CHEMBL526003 galr2_human Human Yes 9.0 Kd = 1 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O
CHEMBL506210 galr2_human Human No 8.7 Kd = 1.8 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None None
CHEMBL503473 galr2_human Human Yes 8.7 Kd = 2 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O
CHEMBL499179 galr2_human Human No 8.6 Kd = 2.3 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None None
CHEMBL2309599 galr2_human Human No 4.6 Kd = 24000 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
678 13 4 7 6.5 Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12
CHEMBL499980 galr2_human Human Yes 8.3 Kd = 5 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None None
CHEMBL604373 galr2_human Human Yes 9.2 Ki = 0.6 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O
CHEMBL501079 galr2_human Human Yes 9.1 Ki = 0.9 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL526003 galr2_human Human Yes 9.0 Ki = 1.1 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O
CHEMBL592413 galr2_human Human No 8.9 Ki = 1.4 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O
CHEMBL604990 galr2_human Human Yes 8.8 Ki = 1.5 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
CHEMBL578710 galr2_human Human Yes 8.8 Ki = 1.7 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(N)=O
CHEMBL503473 galr2_human Human Yes 8.7 Ki = 1.8 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O
CHEMBL501306 galr2_human Human No 7.0 Ki = 108 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL2324949 galr2_human Human No 6.9 Ki = 119 nM Bind
Displacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assayDisplacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assay
None None None CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@]1(C)CCC/C=C/CCC[C@@](C)(C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC1=O)[C@@H](C)O
CHEMBL508083 galr2_human Human No 7.9 Ki = 13 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](C(N)=O)C(C)C
CHEMBL524892 galr2_human Human No 5.9 Ki = 1323.5 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
1957 75 25 24 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL460706 galr2_human Human No 7.8 Ki = 14.4 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2028 72 25 27 -2.5 CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL503900 galr2_human Human No 7.8 Ki = 14.9 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2000 70 25 27 -3.2 CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL450827 galr2_human Human No 7.8 Ki = 15 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2140 80 25 27 0.7 CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL526500 galr2_human Human No 7.8 Ki = 15 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL2324950 galr2_human Human No 7.8 Ki = 15.6 nM Bind
Displacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assayDisplacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assay
None None None CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O
CHEMBL578317 galr2_human Human No 7.8 Ki = 15.9 nM Bind
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
2082 76 25 25 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL507733 galr2_human Human No 7.8 Ki = 16.1 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2056 74 25 27 -1.7 CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL526862 galr2_human Human No 6.8 Ki = 160 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
1935 66 23 23 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O
CHEMBL499807 galr2_human Human No 7.8 Ki = 17.5 nM Bind
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
2097 77 26 26 -0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL524678 galr2_human Human No 7.7 Ki = 18.2 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2084 76 25 27 -0.9 CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL501079 galr2_human Human Yes 8.6 Ki = 2.4 nM Bind
Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL604991 galr2_human Human No 7.7 Ki = 20.2 nM Bind
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
2054 76 25 25 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL505299 galr2_human Human No 7.7 Ki = 20.5 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2122 78 25 32 -5.9 CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O
CHEMBL526889 galr2_human Human No 6.7 Ki = 214.5 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2213 87 29 28 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL592170 galr2_human Human No 6.7 Ki = 218 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(N)=O)[C@@H](C)O
CHEMBL525755 galr2_human Human No 7.7 Ki = 22 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O
CHEMBL499807 galr2_human Human No 7.7 Ki = 22.5 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2097 77 26 26 -0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL508036 galr2_human Human No 7.6 Ki = 24 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
1874 63 25 27 -5.8 CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O
CHEMBL525055 galr2_human Human No 7.6 Ki = 24 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
None None None CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O
CHEMBL504914 galr2_human Human No 7.6 Ki = 28 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL501079 galr2_human Human Yes 8.5 Ki = 3.2 nM Bind
Displacement of radiolabeled galanin from human galanin 2 receptorDisplacement of radiolabeled galanin from human galanin 2 receptor
None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O
CHEMBL2309599 galr2_rat Rat No 4.5 Ki = 34100 nM Bind
Binding affinity to rat GalR2Binding affinity to rat GalR2
678 13 4 7 6.5 Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12
CHEMBL578910 galr2_human Human No 7.5 Ki = 35 nM Bind
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
2111 77 26 26 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL506495 galr2_human Human No 7.3 Ki = 48 nM Bind
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
2040 75 25 25 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL506495 galr2_human Human No 7.3 Ki = 48 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2040 75 25 25 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL504758 galr2_human Human No 7.3 Ki = 51 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2153 81 26 26 0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL578514 galr2_human Human No 7.3 Ki = 51.5 nM Bind
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
2112 78 26 26 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O
CHEMBL507353 galr2_human Human No 7.3 Ki = 51.5 nM Bind
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
2112 78 25 27 -0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL525023 galr2_human Human Yes 7.3 Ki = 51.5 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL578514 galr2_human Human No 7.3 Ki = 52 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
2112 78 26 26 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O
CHEMBL1790054 galr2_human Human No 7.2 Ki = 65.5 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2195 78 32 26 -3.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O
CHEMBL507373 galr2_human Human No 7.1 Ki = 75 nM Bind
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
2014 77 26 25 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O
CHEMBL592415 galr2_human Human No 8.0 Ki = 9.8 nM Bind
Binding affinity to human GalR2Binding affinity to human GalR2
None None None None