Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 1902746 | 32077 | None | 3 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 360 | 6 | 1 | 5 | 3.8 | C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1 | nan | |||
| CHEMBL1408432 | 32077 | None | 3 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 360 | 6 | 1 | 5 | 3.8 | C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1 | nan | |||
| 4104905 | 36512 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 3 | ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | |||
| CHEMBL1447697 | 36512 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 3 | ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | |||
| 1478923 | 51990 | None | 16 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 2 | ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | |||
| CHEMBL1586531 | 51990 | None | 16 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 2 | ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | |||
| 638439 | 103854 | None | 44 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 2 | ChEMBL | 195 | 3 | 1 | 4 | 1.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1O | nan | |||
| CHEMBL309016 | 103854 | None | 44 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 2 | ChEMBL | 195 | 3 | 1 | 4 | 1.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1O | nan | |||
| 4686258 | 51861 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 278 | 4 | 2 | 8 | 1.5 | CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC | nan | |||
| CHEMBL1585420 | 51861 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 278 | 4 | 2 | 8 | 1.5 | CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC | nan | |||
| 3775080 | 37853 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | |||
| CHEMBL1458812 | 37853 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | |||
| 1478923 | 51990 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | |||
| CHEMBL1586531 | 51990 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | ChEMBL | 265 | 4 | 1 | 4 | 2.9 | O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 | nan | |||
| 3775080 | 37853 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | |||
| CHEMBL1458812 | 37853 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 2 | ChEMBL | 306 | 4 | 0 | 6 | 2.9 | CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 | nan | |||
| 2585250 | 28365 | None | 3 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -5 | 3 | ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | |||
| CHEMBL1374788 | 28365 | None | 3 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -5 | 3 | ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | |||
| 5335764 | 45926 | None | 5 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | |||
| CHEMBL1531933 | 45926 | None | 5 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | |||
| 5335764 | 45926 | None | 5 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | |||
| CHEMBL1531933 | 45926 | None | 5 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 | nan | |||
| 5064340 | 40436 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 337 | 3 | 2 | 5 | 5.4 | Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12 | nan | |||
| CHEMBL1482215 | 40436 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 337 | 3 | 2 | 5 | 5.4 | Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12 | nan | |||
| 919665 | 24588 | None | 5 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 343 | 2 | 1 | 5 | 2.5 | CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1 | nan | |||
| CHEMBL1342746 | 24588 | None | 5 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 343 | 2 | 1 | 5 | 2.5 | CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1 | nan | |||
| 2585042 | 46859 | None | 3 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -3 | 4 | ChEMBL | 480 | 4 | 0 | 6 | 2.2 | O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 | nan | |||
| CHEMBL1540377 | 46859 | None | 3 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -3 | 4 | ChEMBL | 480 | 4 | 0 | 6 | 2.2 | O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 | nan | |||
| 1345012 | 34996 | None | 6 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 425 | 5 | 3 | 4 | 4.7 | O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1 | nan | |||
| CHEMBL1432794 | 34996 | None | 6 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 425 | 5 | 3 | 4 | 4.7 | O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1 | nan | |||
| 4104905 | 36512 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 3 | ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | |||
| CHEMBL1447697 | 36512 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 3 | ChEMBL | 297 | 5 | 1 | 7 | 1.6 | CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O | nan | |||
| 2585250 | 28365 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -5 | 3 | ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | |||
| CHEMBL1374788 | 28365 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -5 | 3 | ChEMBL | 396 | 6 | 1 | 5 | 2.2 | CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O | nan | |||
| 260557 | 37021 | None | 17 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 2 | ChEMBL | 326 | 3 | 1 | 4 | 3.7 | CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 | nan | |||
| CHEMBL1451772 | 37021 | None | 17 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 2 | ChEMBL | 326 | 3 | 1 | 4 | 3.7 | CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 | nan | |||
| 3319616 | 31177 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 2 | 3 | ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | |||
| CHEMBL1400481 | 31177 | None | 3 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 2 | 3 | ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | |||
| 3319616 | 31177 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 3 | ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | |||
| CHEMBL1400481 | 31177 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 2 | 3 | ChEMBL | 252 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 | nan | |||
| 11417 | 3648 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 3 | 2 | Guide to Pharmacology | None | None | None | None | 24517231 | |||||
| 8547 | 1292 | None | 0 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | 765 | 13 | 5 | 7 | 7.3 | O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C)CCCNC(=O)OC(C)(C)C)CC1CCCCC1)OCC1C2C=CC=CC2c2c1cccc2 | 20660766 | |||
| 91827369 | 1292 | None | 0 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | 765 | 13 | 5 | 7 | 7.3 | O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C)CCCNC(=O)OC(C)(C)C)CC1CCCCC1)OCC1C2C=CC=CC2c2c1cccc2 | 20660766 | |||
| 11419 | 3264 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 32231393 | |||||
| 6095 | 1739 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3896 | 2443 | None | 0 | Rat | Functional | pEC50 | = | 6.5 | 6.5 | -58 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6095 | 1739 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 16132180 | 1724 | None | 20 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 16133822 | 1724 | None | 20 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6087 | 1724 | None | 20 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 16131409 | 1723 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6086 | 1723 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817479 | 1736 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6083 | 1736 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3898 | 2446 | None | 0 | Rat | Functional | pEC50 | = | 7.5 | 7.5 | -562 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3899 | 2447 | None | 0 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -15 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817484 | 1714 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6117 | 1714 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6129 | 1714 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3899 | 2447 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -32 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817463 | 777 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3861 | 777 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817484 | 1714 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -25 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6117 | 1714 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -25 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6129 | 1714 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -25 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3897 | 2445 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3897 | 2445 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817487 | 1729 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817487 | 1729 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6130 | 1729 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6130 | 1729 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 16133243 | 1715 | None | 0 | Rat | Functional | pEC50 | = | 8.3 | 8.3 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 10601261 | |||||
| 3593 | 1715 | None | 0 | Rat | Functional | pEC50 | = | 8.3 | 8.3 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 10601261 | |||||
| 16132180 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16132180 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 16133822 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133822 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6087 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6087 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3898 | 2446 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -316 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3898 | 2446 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -316 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817463 | 777 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | -2 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3861 | 777 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | -2 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 101927062 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 101927062 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817445 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817445 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 16133823 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133823 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3592 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3592 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 44584852 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 44584852 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6090 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6090 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 91898917 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 91898917 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3896 | 2443 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3896 | 2443 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3896 | 2443 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6120 | 1741 | None | 0 | Rat | Functional | pEC50 | = | 8.6 | 8.6 | 15 | 2 | Guide to Pharmacology | None | None | None | None | 10601261 | |||||
| 16131409 | 1723 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6086 | 1723 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817483 | 1717 | None | 0 | Human | Functional | pEC50 | > | 6 | 6.0 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6094 | 1717 | None | 0 | Human | Functional | pEC50 | > | 6 | 6.0 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817480 | 1731 | None | 0 | Human | Functional | pEC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817480 | 1731 | None | 0 | Rat | Functional | pEC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6091 | 1731 | None | 0 | Human | Functional | pEC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6091 | 1731 | None | 0 | Rat | Functional | pEC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817483 | 1717 | None | 0 | Rat | Functional | pIC50 | = | 6 | 6.0 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6094 | 1717 | None | 0 | Rat | Functional | pIC50 | = | 6 | 6.0 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817475 | 1734 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | Guide to Pharmacology | None | None | None | None | 7683428 | |||||
| 5359 | 1734 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | Guide to Pharmacology | None | None | None | None | 7683428 | |||||
| 155817485 | 1757 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 15944009 | |||||
| 6121 | 1757 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 15944009 | |||||
| 3594 | 1742 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -2 | 3 | Guide to Pharmacology | None | None | None | None | 15944009 | |||||
| 3594 | 1742 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -2 | 3 | Guide to Pharmacology | None | None | None | None | 20880399 | |||||
| 134813891 | 1758 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 15944009 | |||||
| 6122 | 1758 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 15944009 | |||||
| 3896 | 2443 | None | 0 | Rat | Functional | pIC50 | = | 7.9 | 7.9 | -58 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 3896 | 2443 | None | 0 | Rat | Functional | pIC50 | = | 7.9 | 7.9 | -58 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817463 | 777 | None | 0 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 155817463 | 777 | None | 0 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 3861 | 777 | None | 0 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 3861 | 777 | None | 0 | Rat | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817463 | 777 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3861 | 777 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16131409 | 1723 | None | 0 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6086 | 1723 | None | 0 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | -16 | 3 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 16132180 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 16132180 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 16133822 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 16133822 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6087 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 6087 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Functional | pIC50 | = | 8.2 | 8.2 | -89 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 3896 | 2443 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -3 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133243 | 1715 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -7 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133243 | 1715 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -7 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3593 | 1715 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -7 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3593 | 1715 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -7 | 5 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817465 | 1730 | None | 0 | Rat | Functional | pIC50 | = | 8.5 | 8.5 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 3876 | 1730 | None | 0 | Rat | Functional | pIC50 | = | 8.5 | 8.5 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 16131409 | 1723 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6086 | 1723 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3899 | 2447 | None | 0 | Rat | Functional | pIC50 | = | 8.6 | 8.6 | -15 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 3899 | 2447 | None | 0 | Rat | Functional | pIC50 | = | 8.6 | 8.6 | -15 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 16132180 | 1724 | None | 20 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133822 | 1724 | None | 20 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6087 | 1724 | None | 20 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -12 | 4 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817487 | 1729 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817487 | 1729 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6130 | 1729 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6130 | 1729 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 9 | 2 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817474 | 1728 | None | 0 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | 489 | 2 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 5357 | 1728 | None | 0 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | 489 | 2 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 6082 | 3482 | None | 0 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -4 | 2 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 155817473 | 1720 | None | 0 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 5356 | 1720 | None | 0 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 6084 | 1720 | None | 0 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 101927062 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 101927062 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 101927062 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817445 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 155817445 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 155817445 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 16133823 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 16133823 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 16133823 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 3592 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 3592 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 3592 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 44584852 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 44584852 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 44584852 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6090 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 6090 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 6090 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 91898917 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| 91898917 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 91898917 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| CHEMBL506553 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 11481429 | |||||
| CHEMBL506553 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| CHEMBL506553 | 1716 | None | 20 | Rat | Functional | pIC50 | = | 8.8 | 8.8 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 3898 | 2446 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -562 | 4 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 3898 | 2446 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -562 | 4 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 16133243 | 1715 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 10601261 | |||||
| 16133243 | 1715 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 20880399 | |||||
| 16133243 | 1715 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 3593 | 1715 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 10601261 | |||||
| 3593 | 1715 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 20880399 | |||||
| 3593 | 1715 | None | 0 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | -17 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 101927062 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817445 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133823 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3592 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 44584852 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6090 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 91898917 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Functional | pIC50 | = | 9.3 | 9.3 | -24 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817484 | 1714 | None | 0 | Rat | Functional | pIC50 | = | 9.4 | 9.4 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 155817484 | 1714 | None | 0 | Rat | Functional | pIC50 | = | 9.4 | 9.4 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6117 | 1714 | None | 0 | Rat | Functional | pIC50 | = | 9.4 | 9.4 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 6117 | 1714 | None | 0 | Rat | Functional | pIC50 | = | 9.4 | 9.4 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6129 | 1714 | None | 0 | Rat | Functional | pIC50 | = | 9.4 | 9.4 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 6129 | 1714 | None | 0 | Rat | Functional | pIC50 | = | 9.4 | 9.4 | -42 | 5 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817484 | 1714 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -25 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6117 | 1714 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -25 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6129 | 1714 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -25 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 16133243 | 1715 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -7 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 3593 | 1715 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | -7 | 5 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6120 | 1741 | None | 0 | Rat | Functional | pIC50 | = | 9.6 | 9.6 | 15 | 2 | Guide to Pharmacology | None | None | None | None | 10601261 | |||||
| 6124 | 1439 | None | 0 | Human | Functional | pIC50 | > | 4.5 | 4.5 | -158 | 2 | Guide to Pharmacology | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | 10896115 | |||
| 9947811 | 1439 | None | 0 | Human | Functional | pIC50 | > | 4.5 | 4.5 | -158 | 2 | Guide to Pharmacology | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | 10896115 | |||
| CHEMBL3906195 | 1439 | None | 0 | Human | Functional | pIC50 | > | 4.5 | 4.5 | -158 | 2 | Guide to Pharmacology | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | 10896115 | |||
| 131863305 | 327 | None | 0 | Rat | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 20880399 | |||||
| 155817486 | 327 | None | 0 | Rat | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 20880399 | |||||
| 6123 | 327 | None | 0 | Rat | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 20880399 | |||||
| 155817480 | 1731 | None | 0 | Human | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817480 | 1731 | None | 0 | Human | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6091 | 1731 | None | 0 | Human | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6091 | 1731 | None | 0 | Human | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 155817481 | 1732 | None | 0 | Rat | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| 6092 | 1732 | None | 0 | Rat | Functional | pIC50 | > | 6 | 6.0 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 9108306 | |||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 72548703 | 161661 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 161661 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.bmc.2013.03.016 | |||||
| 57392517 | 68826 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921997 | 68826 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57396058 | 68765 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 375 | 6 | 2 | 6 | 5.0 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921902 | 68765 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 375 | 6 | 2 | 6 | 5.0 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57401222 | 68834 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 403 | 6 | 2 | 6 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922004 | 68834 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 403 | 6 | 2 | 6 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57395993 | 68824 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921995 | 68824 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57401225 | 68847 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 437 | 7 | 2 | 7 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922019 | 68847 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 437 | 7 | 2 | 7 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394237 | 68827 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 419 | 8 | 3 | 7 | 5.7 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921998 | 68827 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 419 | 8 | 3 | 7 | 5.7 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57397798 | 68830 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 527 | 6 | 1 | 8 | 5.4 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922000 | 68830 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 527 | 6 | 1 | 8 | 5.4 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57392518 | 68841 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 457 | 7 | 2 | 6 | 5.9 | COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922011 | 68841 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 457 | 7 | 2 | 6 | 5.9 | COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2013.01.044 | |||||
| 101927062 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 155817445 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 16133823 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 3592 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 44584852 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 6090 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 91898917 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -8 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 57399458 | 68832 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 545 | 6 | 1 | 8 | 5.5 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922002 | 68832 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 545 | 6 | 1 | 8 | 5.5 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | |||
| 57395994 | 68831 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 525 | 5 | 1 | 7 | 6.0 | Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922001 | 68831 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 525 | 5 | 1 | 7 | 6.0 | Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| 16078939 | 180818 | None | 23 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 395 | 9 | 2 | 4 | 3.9 | N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O | 10.1016/j.bmcl.2008.10.104 | |||
| CHEMBL475562 | 180818 | None | 23 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 395 | 9 | 2 | 4 | 3.9 | N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O | 10.1016/j.bmcl.2008.10.104 | |||
| CHEMBL514318 | 218085 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| CHEMBL475845 | 216528 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](CS(=O)(=O)O)C(C)=O)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| 57390718 | 68850 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 500 | 8 | 2 | 8 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922023 | 68850 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 500 | 8 | 2 | 8 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL515145 | 218087 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| 57401223 | 68846 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 411 | 9 | 2 | 7 | 5.0 | CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922017 | 68846 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 411 | 9 | 2 | 7 | 5.0 | CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm8007618 | |||||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm701575k | |||||
| 54764411 | 68837 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 459 | 7 | 2 | 7 | 5.9 | COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922007 | 68837 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 459 | 7 | 2 | 7 | 5.9 | COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394235 | 68817 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921988 | 68817 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57399456 | 68821 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 430 | 6 | 1 | 7 | 4.2 | COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921992 | 68821 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 430 | 6 | 1 | 7 | 4.2 | COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57397796 | 68819 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 7 | 4.6 | c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921990 | 68819 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 7 | 4.6 | c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 54764328 | 68836 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 459 | 7 | 2 | 7 | 5.9 | COc1ccc(Nc2nc(Nc3cccc(OC(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922006 | 68836 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 459 | 7 | 2 | 7 | 5.9 | COc1ccc(Nc2nc(Nc3cccc(OC(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 54764412 | 68843 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 407 | 6 | 2 | 6 | 5.4 | COc1ccc(Nc2nc(Nc3cccc(F)c3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922013 | 68843 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 407 | 6 | 2 | 6 | 5.4 | COc1ccc(Nc2nc(Nc3cccc(F)c3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57401220 | 68818 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921989 | 68818 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394241 | 68844 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 427 | 6 | 2 | 6 | 5.8 | COc1ccc(Nc2nc(Nc3ccc(F)c(Cl)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922014 | 68844 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 427 | 6 | 2 | 6 | 5.8 | COc1ccc(Nc2nc(Nc3ccc(F)c(Cl)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394240 | 68840 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 423 | 7 | 2 | 7 | 5.1 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922010 | 68840 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 423 | 7 | 2 | 7 | 5.1 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57397799 | 68835 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 6 | 5.6 | COc1ccc(Nc2nc(Nc3cc(C)ccc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922005 | 68835 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 6 | 5.6 | COc1ccc(Nc2nc(Nc3cc(C)ccc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL474037 | 216515 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| 57394303 | 68764 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 373 | 5 | 2 | 5 | 5.6 | Cc1ccc(C)c(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921901 | 68764 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 373 | 5 | 2 | 5 | 5.6 | Cc1ccc(C)c(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394239 | 68839 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 441 | 8 | 2 | 7 | 5.6 | COc1ccc(Nc2nc(Nc3cccc(OC(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922009 | 68839 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 441 | 8 | 2 | 7 | 5.6 | COc1ccc(Nc2nc(Nc3cccc(OC(F)F)c3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL474038 | 216516 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| 57399457 | 68828 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921999 | 68828 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394238 | 68833 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 529 | 5 | 1 | 7 | 5.8 | Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922003 | 68833 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 529 | 5 | 1 | 7 | 5.8 | Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL473840 | 216514 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| 57394304 | 68766 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 429 | 6 | 2 | 6 | 5.9 | FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921903 | 68766 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 429 | 6 | 2 | 6 | 5.9 | FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57401221 | 68825 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921996 | 68825 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57390716 | 68845 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 437 | 7 | 2 | 7 | 5.5 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922016 | 68845 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 437 | 7 | 2 | 7 | 5.5 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57399459 | 68838 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 443 | 6 | 2 | 6 | 6.0 | COc1ccc(Nc2nc(Nc3ccc(C(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922008 | 68838 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 443 | 6 | 2 | 6 | 6.0 | COc1ccc(Nc2nc(Nc3ccc(C(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57397797 | 68823 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 391 | 7 | 2 | 7 | 4.6 | COc1ccc(Nc2cc(Nc3ccc(OC)cc3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921994 | 68823 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 391 | 7 | 2 | 7 | 4.6 | COc1ccc(Nc2cc(Nc3ccc(OC)cc3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57395992 | 68820 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 393 | 6 | 2 | 6 | 5.1 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921991 | 68820 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 393 | 6 | 2 | 6 | 5.1 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL451169 | 216428 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCC(C)=O)NC(=O)[C@H]2CCCCN2C1=O | 10.1016/j.bmcl.2008.10.104 | |||||
| 57401228 | 68852 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 538 | 7 | 2 | 9 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922025 | 68852 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 538 | 7 | 2 | 9 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57394236 | 68822 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 391 | 7 | 2 | 7 | 4.6 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1921993 | 68822 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 391 | 7 | 2 | 7 | 4.6 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| 57395995 | 68842 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 407 | 6 | 2 | 6 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(F)cc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL1922012 | 68842 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 407 | 6 | 2 | 6 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(F)cc3C)cc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | |||
| CHEMBL526003 | 218159 | None | 24 | Human | Binding | pKd | = | 9 | 9.0 | -10 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | |||||
| CHEMBL506210 | 216693 | None | 0 | Human | Binding | pKd | = | 8.7 | 8.7 | 478 | 2 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| CHEMBL503473 | 216655 | None | 15 | Human | Binding | pKd | = | 8.7 | 8.7 | -60 | 3 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | |||||
| 155817464 | 1499 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | -5 | 4 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| 3866 | 1499 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | -5 | 4 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| 44587986 | 1499 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | -5 | 4 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| 91934870 | 1499 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | -5 | 4 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| CHEMBL499179 | 1499 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | -5 | 4 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| 71717271 | 86124 | None | 0 | Human | Binding | pKd | = | 4.6 | 4.6 | -1 | 3 | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm801088x | |||
| CHEMBL2309599 | 86124 | None | 0 | Human | Binding | pKd | = | 4.6 | 4.6 | -1 | 3 | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm801088x | |||
| 16132180 | 1724 | None | 20 | Human | Binding | pKd | = | 8.3 | 8.3 | -3 | 8 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| 16133822 | 1724 | None | 20 | Human | Binding | pKd | = | 8.3 | 8.3 | -3 | 8 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| 6087 | 1724 | None | 20 | Human | Binding | pKd | = | 8.3 | 8.3 | -3 | 8 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Binding | pKd | = | 8.3 | 8.3 | -3 | 8 | ChEMBL | None | None | None | None | 10.1021/jm801088x | |||||
| CHEMBL604373 | 218312 | None | 5 | Human | Binding | pKi | = | 9.2 | 9.2 | -7 | 2 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm9018349 | |||||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pKi | = | 9.1 | 9.1 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9018349 | |||||
| CHEMBL526003 | 218159 | None | 24 | Human | Binding | pKi | = | 9.0 | 9.0 | -10 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm9018349 | |||||
| CHEMBL592413 | 218299 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -4 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm9018349 | |||||
| CHEMBL604990 | 218314 | None | 22 | Human | Binding | pKi | = | 8.8 | 8.8 | -15 | 2 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9018349 | |||||
| CHEMBL578710 | 218268 | None | 22 | Human | Binding | pKi | = | 8.8 | 8.8 | 501 | 2 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(N)=O | 10.1021/jm9018349 | |||||
| CHEMBL503473 | 216655 | None | 15 | Human | Binding | pKi | = | 8.7 | 8.7 | -60 | 3 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm9018349 | |||||
| 25180488 | 188473 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -4 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL501306 | 188473 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -4 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL2324949 | 211986 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@]1(C)CCC/C=C/CCC[C@@](C)(C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC1=O)[C@@H](C)O | 10.1016/j.bmc.2012.10.026 | |||||
| CHEMBL508083 | 217196 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -25 | 2 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm801088x | |||||
| 25180498 | 193465 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 2 | ChEMBL | 1957 | 75 | 25 | 24 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL524892 | 193465 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -4 | 2 | ChEMBL | 1957 | 75 | 25 | 24 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| 44563953 | 176905 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -11 | 2 | ChEMBL | 2028 | 72 | 25 | 27 | -2.5 | CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL460706 | 176905 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -11 | 2 | ChEMBL | 2028 | 72 | 25 | 27 | -2.5 | CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| 44563952 | 188785 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -20 | 2 | ChEMBL | 2000 | 70 | 25 | 27 | -3.2 | CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL503900 | 188785 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -20 | 2 | ChEMBL | 2000 | 70 | 25 | 27 | -3.2 | CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| 44563957 | 172845 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 2 | ChEMBL | 2140 | 80 | 25 | 27 | 0.7 | CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL450827 | 172845 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 2 | ChEMBL | 2140 | 80 | 25 | 27 | 0.7 | CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| 25180491 | 193560 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -16 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL526500 | 193560 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -16 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL2324950 | 211987 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -4 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O | 10.1016/j.bmc.2012.10.026 | |||||
| 45104656 | 201028 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -9 | 2 | ChEMBL | 2082 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| CHEMBL578317 | 201028 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -9 | 2 | ChEMBL | 2082 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| 44563954 | 189020 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -11 | 2 | ChEMBL | 2056 | 74 | 25 | 27 | -1.7 | CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL507733 | 189020 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -11 | 2 | ChEMBL | 2056 | 74 | 25 | 27 | -1.7 | CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| 25180486 | 193684 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -1 | 2 | ChEMBL | 1935 | 66 | 23 | 23 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | |||
| 44587983 | 193684 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -1 | 2 | ChEMBL | 1935 | 66 | 23 | 23 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL526862 | 193684 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -1 | 2 | ChEMBL | 1935 | 66 | 23 | 23 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | |||
| 25180489 | 188367 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -5 | 2 | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| CHEMBL499807 | 188367 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -5 | 2 | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| 44563955 | 193451 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -7 | 2 | ChEMBL | 2084 | 76 | 25 | 27 | -0.9 | CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL524678 | 193451 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -7 | 2 | ChEMBL | 2084 | 76 | 25 | 27 | -0.9 | CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pKi | = | 8.6 | 8.6 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2013.01.044 | |||||
| 45104657 | 203918 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | 18 | 2 | ChEMBL | 2054 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| CHEMBL604991 | 203918 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | 18 | 2 | ChEMBL | 2054 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| 44563958 | 188861 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -40 | 2 | ChEMBL | 2122 | 78 | 25 | 32 | -5.9 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | |||
| CHEMBL505299 | 188861 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -40 | 2 | ChEMBL | 2122 | 78 | 25 | 32 | -5.9 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | |||
| 25180497 | 193693 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -5 | 2 | ChEMBL | 2213 | 87 | 29 | 28 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL526889 | 193693 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -5 | 2 | ChEMBL | 2213 | 87 | 29 | 28 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL592170 | 218298 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(N)=O)[C@@H](C)O | 10.1021/jm9018349 | |||||
| 25180487 | 193511 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -11 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL525755 | 193511 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -11 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | |||
| 25180489 | 188367 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -5 | 2 | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL499807 | 188367 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -5 | 2 | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| 44563951 | 189045 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -60 | 2 | ChEMBL | 1874 | 63 | 25 | 27 | -5.8 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | |||
| CHEMBL508036 | 189045 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -60 | 2 | ChEMBL | 1874 | 63 | 25 | 27 | -5.8 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | |||
| CHEMBL525055 | 218124 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -60 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801088x | |||||
| 25180494 | 188837 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -4 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL504914 | 188837 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -4 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL501079 | 216618 | None | 9 | Human | Binding | pKi | = | 8.5 | 8.5 | -11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm8007618 | |||||
| 71717271 | 86124 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 3 | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm9018349 | |||
| CHEMBL2309599 | 86124 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 3 | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm9018349 | |||
| 45104655 | 201083 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -3 | 2 | ChEMBL | 2111 | 77 | 26 | 26 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| CHEMBL578910 | 201083 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -3 | 2 | ChEMBL | 2111 | 77 | 26 | 26 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| 25180495 | 188940 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 8 | 2 | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| CHEMBL506495 | 188940 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 8 | 2 | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | |||
| 25180495 | 188940 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 8 | 2 | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL506495 | 188940 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 8 | 2 | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| 25180496 | 188828 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -2 | 2 | ChEMBL | 2153 | 81 | 26 | 26 | 0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL504758 | 188828 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -2 | 2 | ChEMBL | 2153 | 81 | 26 | 26 | 0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| 24760995 | 201043 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | |||
| CHEMBL578514 | 201043 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | |||
| 44563956 | 188997 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2112 | 78 | 25 | 27 | -0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| CHEMBL507353 | 188997 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2112 | 78 | 25 | 27 | -0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | |||
| 44587984 | 193473 | None | 4 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL525023 | 193473 | None | 4 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| 24760995 | 201043 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | |||
| CHEMBL578514 | 201043 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | |||
| 25180490 | 63205 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -19 | 2 | ChEMBL | 2195 | 78 | 32 | 26 | -3.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | |||
| 91934869 | 63205 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -19 | 2 | ChEMBL | 2195 | 78 | 32 | 26 | -3.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL1790054 | 63205 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -19 | 2 | ChEMBL | 2195 | 78 | 32 | 26 | -3.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | |||
| 25180492 | 188999 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -2 | 2 | ChEMBL | 2014 | 77 | 26 | 25 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL507373 | 188999 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -2 | 2 | ChEMBL | 2014 | 77 | 26 | 25 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | |||
| CHEMBL592415 | 218300 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 5 | 2 | ChEMBL | None | None | None | None | 10.1021/jm9018349 | |||||
| 155817484 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 155817484 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 155817484 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9578584 | |||||
| 155817484 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6117 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 6117 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6117 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9578584 | |||||
| 6117 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6129 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 6129 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9427506 | |||||
| 6129 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9578584 | |||||
| 6129 | 1714 | None | 0 | Rat | Binding | pKd | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 155817484 | 1714 | None | 0 | Human | Binding | pKd | = | 9.5 | 9.5 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6117 | 1714 | None | 0 | Human | Binding | pKd | = | 9.5 | 9.5 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6129 | 1714 | None | 0 | Human | Binding | pKd | = | 9.5 | 9.5 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817484 | 1714 | None | 0 | Human | Binding | pKd | = | 9.9 | 9.9 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6117 | 1714 | None | 0 | Human | Binding | pKd | = | 9.9 | 9.9 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 6129 | 1714 | None | 0 | Human | Binding | pKd | = | 9.9 | 9.9 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9685625 | |||||
| 24748735 | 1755 | None | 2 | Rat | Binding | pKd | > | 5 | 5.0 | 3 | 2 | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15240875 | |||
| 24748735 | 1755 | None | 2 | Rat | Binding | pKd | > | 5 | 5.0 | 3 | 2 | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15944002 | |||
| 6119 | 1755 | None | 2 | Rat | Binding | pKd | > | 5 | 5.0 | 3 | 2 | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15240875 | |||
| 6119 | 1755 | None | 2 | Rat | Binding | pKd | > | 5 | 5.0 | 3 | 2 | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15944002 | |||
| CHEMBL1187471 | 1755 | None | 2 | Rat | Binding | pKd | > | 5 | 5.0 | 3 | 2 | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15240875 | |||
| CHEMBL1187471 | 1755 | None | 2 | Rat | Binding | pKd | > | 5 | 5.0 | 3 | 2 | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15944002 | |||
| 16131409 | 1723 | 125I-GALANIN | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | 4 | 3 | PDSP KiDatabase | None | None | None | None | None | |||||
| 6086 | 1723 | 125I-GALANIN | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | 4 | 3 | PDSP KiDatabase | None | None | None | None | None | |||||
| None | 218550 | 125I-h Galanin | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| None | 218550 | 125I-GALANIN | 0 | Rat | Binding | pKi | = | 9 | 9.0 | -1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| None | 218550 | 125I-GALANIN | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| None | 218550 | 125I-p Galanin | 0 | Rat | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| None | 218550 | 125I-h Galanin | 0 | Rat | Binding | pKi | = | 8.9 | 8.9 | -1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| None | 218550 | 125I-GALANIN | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| None | 218550 | 125I-GALANIN | 0 | Rat | Binding | pKi | = | 7.6 | 7.6 | -1 | 6 | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | |||
| 5311268 | 1756 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 2 | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15240875 | |||
| 5311268 | 1756 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 2 | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15944002 | |||
| 6118 | 1756 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 2 | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15240875 | |||
| 6118 | 1756 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 2 | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15944002 | |||
| CHEMBL592414 | 1756 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 2 | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15240875 | |||
| CHEMBL592414 | 1756 | None | 0 | Rat | Binding | pKi | = | 4.5 | 4.5 | -2 | 2 | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15944002 | |||
| 155817481 | 1732 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -2 | 6 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 155817481 | 1732 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -2 | 6 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 155817481 | 1732 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -2 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6092 | 1732 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -2 | 6 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 6092 | 1732 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -2 | 6 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 6092 | 1732 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -2 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6095 | 1739 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -14 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817474 | 1728 | None | 0 | Rat | Binding | pKi | = | 7.1 | 7.1 | -5 | 5 | Guide to Pharmacology | None | None | None | None | 15944007 | |||||
| 5357 | 1728 | None | 0 | Rat | Binding | pKi | = | 7.1 | 7.1 | -5 | 5 | Guide to Pharmacology | None | None | None | None | 15944007 | |||||
| 6108 | 1760 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 23259957 | |||||
| 6105 | 1744 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -14 | 2 | Guide to Pharmacology | None | None | None | None | 19053761 | |||||
| 6107 | 1752 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 8 | 2 | Guide to Pharmacology | None | None | None | None | 19053761 | |||||
| 6103 | 2440 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | 18 | 3 | Guide to Pharmacology | None | None | None | None | 21333705 | |||||
| 6074 | 2442 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 301 | 3 | Guide to Pharmacology | None | None | None | None | 23192661 | |||||
| 6102 | 2439 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 3 | 3 | Guide to Pharmacology | None | None | None | None | 21333705 | |||||
| 6110 | 1753 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -60 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 6116 | 1751 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -40 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 6109 | 2832 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | 17 | 2 | Guide to Pharmacology | None | None | None | None | 20121116 | |||||
| 6075 | 2108 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | 5 | 3 | Guide to Pharmacology | None | None | None | None | 23600864 | |||||
| 6114 | 1747 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -7 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 155817474 | 1728 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 5 | 5 | Guide to Pharmacology | None | None | None | None | 19467704 | |||||
| 5357 | 1728 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 5 | 5 | Guide to Pharmacology | None | None | None | None | 19467704 | |||||
| 6113 | 1746 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -11 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 6115 | 1748 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 6111 | 1749 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -20 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 6112 | 1745 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -11 | 2 | Guide to Pharmacology | None | None | None | None | 19199479 | |||||
| 155817463 | 777 | None | 0 | Mouse | Binding | pKi | = | 7.9 | 7.9 | -58 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3861 | 777 | None | 0 | Mouse | Binding | pKi | = | 7.9 | 7.9 | -58 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6095 | 1739 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 14 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6095 | 1739 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | 14 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6106 | 1750 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -10 | 2 | Guide to Pharmacology | None | None | None | None | 23259957 | |||||
| 3900 | 2451 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 31 | 3 | Guide to Pharmacology | None | None | None | None | None | |||||
| 3897 | 2445 | None | 0 | Rat | Binding | pKi | = | 7.9 | 7.9 | -13 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 16132180 | 1724 | None | 20 | Mouse | Binding | pKi | = | 7.9 | 7.9 | -7 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 16133822 | 1724 | None | 20 | Mouse | Binding | pKi | = | 7.9 | 7.9 | -7 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6087 | 1724 | None | 20 | Mouse | Binding | pKi | = | 7.9 | 7.9 | -7 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| CHEMBL499980 | 1724 | None | 20 | Mouse | Binding | pKi | = | 7.9 | 7.9 | -7 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 155817465 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 155817465 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 155817465 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 155817465 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3876 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 3876 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 3876 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 3876 | 1730 | None | 0 | Rat | Binding | pKi | = | 8.0 | 8.0 | -11 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 155817464 | 1499 | None | 0 | Rat | Binding | pKi | = | 8.2 | 8.2 | -17 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3866 | 1499 | None | 0 | Rat | Binding | pKi | = | 8.2 | 8.2 | -17 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 44587986 | 1499 | None | 0 | Rat | Binding | pKi | = | 8.2 | 8.2 | -17 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 91934870 | 1499 | None | 0 | Rat | Binding | pKi | = | 8.2 | 8.2 | -17 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| CHEMBL499179 | 1499 | None | 0 | Rat | Binding | pKi | = | 8.2 | 8.2 | -17 | 4 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817465 | 1730 | None | 0 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -7 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3876 | 1730 | None | 0 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -7 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6101 | 2438 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | 75 | 3 | Guide to Pharmacology | None | None | None | None | 19467704 | |||||
| 6141 | 1721 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6099 | 2444 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -23 | 2 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 6100 | 2449 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -25 | 3 | Guide to Pharmacology | None | None | None | None | None | |||||
| 6104 | 2441 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | 45 | 3 | Guide to Pharmacology | None | None | None | None | 21333705 | |||||
| 16132180 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 16132180 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 16132180 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 16132180 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 16132180 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 16132180 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 16133822 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 16133822 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 16133822 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 16133822 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 16133822 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 16133822 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6087 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 6087 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6087 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 6087 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6087 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 6087 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| CHEMBL499980 | 1724 | None | 20 | Rat | Binding | pKi | = | 8.3 | 8.3 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 155817479 | 1736 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6083 | 1736 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6076 | 2109 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 23600864 | |||||
| 3898 | 2446 | None | 0 | Mouse | Binding | pKi | = | 8.3 | 8.3 | -20 | 7 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6139 | 1726 | None | 0 | Rat | Binding | pKi | = | 8.3 | 8.3 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 16132180 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 19053761 | |||||
| 16132180 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 16132180 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 16133822 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 19053761 | |||||
| 16133822 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 16133822 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6087 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 19053761 | |||||
| 6087 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6087 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 19053761 | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| CHEMBL499980 | 1724 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 101927062 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 101927062 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 155817445 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 155817445 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 16133823 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 16133823 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3592 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 3592 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 44584852 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 44584852 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6090 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 6090 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 91898917 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| 91898917 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11983932 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Binding | pKi | = | 8.4 | 8.4 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3896 | 2443 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | -38 | 7 | Guide to Pharmacology | None | None | None | None | 15944002 | |||||
| 3896 | 2443 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | -38 | 7 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 3896 | 2443 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | -38 | 7 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3896 | 2443 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | -38 | 7 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 3896 | 2443 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | -38 | 7 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 3896 | 2443 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | -38 | 7 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 16133243 | 1715 | None | 0 | Mouse | Binding | pKi | = | 8.4 | 8.4 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3593 | 1715 | None | 0 | Mouse | Binding | pKi | = | 8.4 | 8.4 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3899 | 2447 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 15944002 | |||||
| 3899 | 2447 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 3899 | 2447 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3899 | 2447 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 3899 | 2447 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 3899 | 2447 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -26 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 16131409 | 1723 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -4 | 3 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6086 | 1723 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -4 | 3 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 155817463 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 155817463 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817463 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 155817463 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3861 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 3861 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3861 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 3861 | 777 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | -13 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 155817487 | 1729 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 8 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6130 | 1729 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 8 | 4 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3899 | 2447 | None | 0 | Mouse | Binding | pKi | = | 8.6 | 8.6 | -21 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 101927062 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 155817445 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 16133823 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 3592 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 44584852 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6090 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 91898917 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| CHEMBL506553 | 1716 | None | 20 | Rat | Binding | pKi | = | 8.6 | 8.6 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 155817479 | 1736 | None | 0 | Rat | Binding | pKi | = | 8.6 | 8.6 | 1 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6083 | 1736 | None | 0 | Rat | Binding | pKi | = | 8.6 | 8.6 | 1 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3899 | 2447 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -18 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3899 | 2447 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -18 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3898 | 2446 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | -9 | 7 | Guide to Pharmacology | None | None | None | None | 15944002 | |||||
| 3898 | 2446 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | -9 | 7 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 3898 | 2446 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | -9 | 7 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3898 | 2446 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | -9 | 7 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 3898 | 2446 | None | 0 | Rat | Binding | pKi | = | 8.7 | 8.7 | -9 | 7 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 16133243 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 19467704 | |||||
| 16133243 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 21333705 | |||||
| 16133243 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 16133243 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3593 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 19467704 | |||||
| 3593 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 21333705 | |||||
| 3593 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3593 | 1715 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -14 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3898 | 2446 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -7 | 7 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3898 | 2446 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -7 | 7 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 16133243 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 15944002 | |||||
| 16133243 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 16133243 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 16133243 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 16133243 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 16133243 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3593 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 15944002 | |||||
| 3593 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 3593 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 3593 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 3593 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9742938 | |||||
| 3593 | 1715 | None | 0 | Rat | Binding | pKi | = | 8.8 | 8.8 | -12 | 8 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 3897 | 2445 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 3897 | 2445 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 101927062 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 101927062 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 101927062 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817445 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 155817445 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 155817445 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 16133823 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 16133823 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 16133823 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3592 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 3592 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3592 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 44584852 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 44584852 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 44584852 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6090 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 6090 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6090 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 91898917 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| 91898917 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 91898917 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 11600206 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| CHEMBL506553 | 1716 | None | 20 | Human | Binding | pKi | = | 8.9 | 8.9 | -8 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3896 | 2443 | None | 0 | Mouse | Binding | pKi | = | 8.9 | 8.9 | -13 | 7 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 155817463 | 777 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -4 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 155817463 | 777 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -4 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 3861 | 777 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -4 | 8 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3861 | 777 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -4 | 8 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817484 | 1714 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6117 | 1714 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6129 | 1714 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817465 | 1730 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 7 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 3876 | 1730 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 7 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6137 | 1727 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 155817484 | 1714 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817484 | 1714 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6117 | 1714 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6117 | 1714 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6129 | 1714 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6129 | 1714 | None | 0 | Rat | Binding | pKi | = | 9.1 | 9.1 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 16131409 | 1723 | None | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | 4 | 3 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6086 | 1723 | None | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | 4 | 3 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3897 | 2445 | None | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | -13 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 3897 | 2445 | None | 0 | Rat | Binding | pKi | = | 9.2 | 9.2 | -13 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6127 | 1761 | None | 0 | Rat | Binding | pKi | > | 5 | 5.0 | -575 | 3 | Guide to Pharmacology | 397 | 3 | 0 | 4 | 5.2 | COc1ccc(cn1)N1C(=O)/C(=N/c2ccc(c(c2)Cl)Cl)/c2c1cccc2 | 15944002 | |||
| 9800980 | 1761 | None | 0 | Rat | Binding | pKi | > | 5 | 5.0 | -575 | 3 | Guide to Pharmacology | 397 | 3 | 0 | 4 | 5.2 | COc1ccc(cn1)N1C(=O)/C(=N/c2ccc(c(c2)Cl)Cl)/c2c1cccc2 | 15944002 | |||
| 1471834 | 3629 | None | 40 | Human | Binding | pKi | > | 5 | 5.0 | -588 | 3 | Guide to Pharmacology | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 16287967 | |||
| 6126 | 3629 | None | 40 | Human | Binding | pKi | > | 5 | 5.0 | -588 | 3 | Guide to Pharmacology | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 16287967 | |||
| CHEMBL210288 | 3629 | None | 40 | Human | Binding | pKi | > | 5 | 5.0 | -588 | 3 | Guide to Pharmacology | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 16287967 | |||
| 155817481 | 1732 | None | 0 | Mouse | Binding | pKi | > | 5.7 | 5.7 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6092 | 1732 | None | 0 | Mouse | Binding | pKi | > | 5.7 | 5.7 | -3 | 6 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 155817482 | 1718 | None | 0 | Mouse | Binding | pKi | > | 5.7 | 5.7 | -2 | 3 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6093 | 1718 | None | 0 | Mouse | Binding | pKi | > | 5.7 | 5.7 | -2 | 3 | Guide to Pharmacology | None | None | None | None | 9832122 | |||||
| 6133 | 1494 | None | 0 | Rat | Binding | pKi | > | 5.9 | 5.9 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 155817480 | 1731 | None | 0 | Human | Binding | pKi | > | 6 | 6.0 | 1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 155817480 | 1731 | None | 0 | Rat | Binding | pKi | > | 6 | 6.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 155817480 | 1731 | None | 0 | Rat | Binding | pKi | > | 6 | 6.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6091 | 1731 | None | 0 | Human | Binding | pKi | > | 6 | 6.0 | 1 | 6 | Guide to Pharmacology | None | None | None | None | 9880084 | |||||
| 6091 | 1731 | None | 0 | Rat | Binding | pKi | > | 6 | 6.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9305929 | |||||
| 6091 | 1731 | None | 0 | Rat | Binding | pKi | > | 6 | 6.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 9722565 | |||||
| 6132 | 1830 | None | 0 | Rat | Binding | pKi | > | 6 | 6.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 9405385 | |||||
| 11698643 | 3630 | None | 12 | Human | Binding | pKi | > | 6 | 6.0 | -194 | 4 | Guide to Pharmacology | 479 | 6 | 0 | 4 | 6.0 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 | 16287967 | |||
| 6125 | 3630 | None | 12 | Human | Binding | pKi | > | 6 | 6.0 | -194 | 4 | Guide to Pharmacology | 479 | 6 | 0 | 4 | 6.0 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 | 16287967 | |||
| CHEMBL209497 | 3630 | None | 12 | Human | Binding | pKi | > | 6 | 6.0 | -194 | 4 | Guide to Pharmacology | 479 | 6 | 0 | 4 | 6.0 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 | 16287967 | |||
| 6131 | 1829 | None | 0 | Rat | Binding | pKi | > | 6.1 | 6.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9281594 | |||||
| 155817482 | 1718 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6093 | 1718 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6140 | 1719 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 155817481 | 1732 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | 1 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6092 | 1732 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | 1 | 6 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6138 | 1733 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6134 | 1735 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6136 | 1737 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||
| 6135 | 1738 | None | 0 | Human | Binding | pKi | > | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480833 | |||||